CA2651445A1 - Solid medicament dosage form consumption aid - Google Patents

Solid medicament dosage form consumption aid Download PDF

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Publication number
CA2651445A1
CA2651445A1 CA002651445A CA2651445A CA2651445A1 CA 2651445 A1 CA2651445 A1 CA 2651445A1 CA 002651445 A CA002651445 A CA 002651445A CA 2651445 A CA2651445 A CA 2651445A CA 2651445 A1 CA2651445 A1 CA 2651445A1
Authority
CA
Canada
Prior art keywords
liquid formula
group
formula according
medicament
adhesion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002651445A
Other languages
French (fr)
Other versions
CA2651445C (en
Inventor
Jerald David Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2651445A1 publication Critical patent/CA2651445A1/en
Application granted granted Critical
Publication of CA2651445C publication Critical patent/CA2651445C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Abstract

A flavored, lubricating solution is applied to a solid medicament by spra y, dipping, or otherwise coating the medicament. This liquid coating masks t he often objectionable taste of the medicament while lubricating it, and thu s significantly improving the ability to swallow the medicament. The improve ment to the swallowing process is dramatically enhanced with significant red uction in gag reflex, general un-palatability and inability to move the dosa ge form completely through the mouth, palate, and esophagus to the stomach w ithout sticking or lodging at any point in the process. The solution is a mi xture of viscosity-adhesion-lubricity ingredients which includes polyols and polysaccharides, preservative agents, flavoring agents (to improve the pala tability of the solution) and optional dispensing agents.

Claims (23)

1. A liquid formula for application to a solid medicament comprising:
a viscosity-adhesion-lubricity agent selected from the group consisting of sugar-alcohols, polyols, polysaccharides and mixtures thereof;
favoring agents; and purified water, wherein the liquid formula is formulated to form an adherent and slippery coating when applied to a surface.
2. The liquid formula according to claim 1 further comprising a preservative agent.
3. The liquid formula according to claim 2, wherein the preservative agent is selected from the group consisting of citric acid, sodium citrate, sulfites, propionic acid, methylparaben, propylparaben, benzoates, sorbates, and EDTA.
4. The liquid formula according to claim 3, wherein the preservative agent is selected from the group consisting of citric acid, sodium citrate, sulfites, propionic acid, methylparaben, propylparaben, benzoate, sorbate and EDTA.
5. The liquid formula according to claim 1, wherein the benzoate is sodium benzoate and the sorbate is sodium potassium sorbate.
6. The liquid formula according to claim 1, wherein the sugar alcohol is selected from the group consisting of galactitol, erythritol, inositol, maltitol, mannitol, ribitol, sorbitol and xylitol.
7. The liquid formula according to claim 1, wherein the polyol is selected from the group consisting of glycerin, propylene glycol and polyethylene glycol.
8. The liquid formula according to claim 1, wherein the polysaccharide, is selected from the group consisting of xanthan gum, carboxymethylcellulose, alginate and carregenan.
9. The liquid formula according to claim 1, wherein the viscosity adhesion-lubricity agent is a mixture of sorbitol and xanthan gum, wherein neotame is included as a sweetener and wherein sodium benzoate and sodium potassium sorbate are included as preservatives.
10. The liquid formula according to claim 7, wherein the polysaccharide further comprises microcrystalline cellulose.
11. The liquid formula according to claim 1 comprising between 0%
and about 40% by weight sorbitol and about 25% and about 75% by weight glycerin as viscosity-adhesion-lubricity agents.
12. The liquid formula according to claim 11, wherein the flavoring agents comprise sorbitol.
13. The liquid formula according to claim 11 further comprising an artificial sweetener.
14. The liquid formula according to claim 11 further comprising a preservative agent.
15. A method for facilitating the swallowing of a solid medicament comprising the steps of:
providing a sprayer containing an aqueous solution of a viscosity-adhesion-lubricity agent formulated to adhere to and to provide a slippery coating on a surface;
operating the sprayer to coat a solid medicament with the aqueous solution to form a slippery coating adhering to the solid, medicament; and ingesting the coated medicament whereby swallowing the medicament is facilitated by the adherent slippery coating.
16. The method according to claim 15, wherein the aqueous solution further comprises an artificial sweetener.
17. The method according to claim 15, wherein the aqueous solution further comprises a preservative agent.
18. The method according to claim 17, wherein the preservative agent is selected from the group consisting of citric acid, sodium citrate, sulfites, propionic acid, methylparaben, propylparaben, benzoates, sorbates, and EDTA.
19. The method according to claim 15, wherein the aqueous solution further comprises a flavoring agent.
20. The method according to claim 15, wherein the aqueous solution viscosity-adhesion-lubricity agent comprises a sugar alcohol selected from the group consisting of galactitol erythritol, inositol, maltitol, mannitol, ribitol, sorbitol and xylitol.
21. The method according to claim 15, wherein the viscosity-adhesion-lubricity agent comprises a polyol selected from the group consisting of glycerin, propylene glycol and polyethylene glycol.
22. The method according to claim 15, wherein the viscosity-adhesion-lubricity agent comprises a polysaccharide selected from the group consisting of xanthan gum, carboxymethylcellulose, alginate and carregenan.
23. The method according to claim 15, wherein the aqueous solution comprises a mixture of sorbitol and xanthan gum with neotame included as a sweetener and sodium benzoate and sodium potassium sorbate as preservatives.
CA2651445A 2006-05-02 2007-05-02 Solid medicament dosage form consumption aid Active CA2651445C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/381,281 2006-05-02
US11/381,281 US8187659B2 (en) 2006-05-02 2006-05-02 Solid medicament dosage form consumption aid
PCT/US2007/068012 WO2007143311A2 (en) 2006-05-02 2007-05-02 Solid medicament dosage form consumption aid

Publications (2)

Publication Number Publication Date
CA2651445A1 true CA2651445A1 (en) 2007-12-13
CA2651445C CA2651445C (en) 2012-07-17

Family

ID=38661458

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2651445A Active CA2651445C (en) 2006-05-02 2007-05-02 Solid medicament dosage form consumption aid

Country Status (3)

Country Link
US (1) US8187659B2 (en)
CA (1) CA2651445C (en)
WO (1) WO2007143311A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070275053A1 (en) * 2006-05-26 2007-11-29 Luise Anneliese Lenk Anti-stick formula delivered by spray process to facilitate swallowing of solid object, such as pill, tablet capsule or caplet.
US20120204866A1 (en) * 2008-02-21 2012-08-16 Kizer Robert T System and methods of intubation
US8834694B2 (en) * 2010-12-27 2014-09-16 Mo Bio Laboratories, Inc. Dry compositions and methods for gel electrophoresis
US10016357B2 (en) * 2012-03-22 2018-07-10 The Beauty Factory, Llc Personal lubricants
CN110721484B (en) * 2018-06-12 2021-04-27 贝曼创意科技(东莞)有限公司 Small-particle building block toy capable of preventing child from mistakenly swallowing and using method thereof
US10857092B2 (en) * 2019-03-14 2020-12-08 Glen D Lindbo Avoiding gag reflex to enable swallowing pills

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Also Published As

Publication number Publication date
US20070259038A1 (en) 2007-11-08
CA2651445C (en) 2012-07-17
WO2007143311A3 (en) 2008-04-10
WO2007143311A2 (en) 2007-12-13
US8187659B2 (en) 2012-05-29

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