CA2655793A1 - Medical devices with selective coating - Google Patents

Medical devices with selective coating Download PDF

Info

Publication number
CA2655793A1
CA2655793A1 CA002655793A CA2655793A CA2655793A1 CA 2655793 A1 CA2655793 A1 CA 2655793A1 CA 002655793 A CA002655793 A CA 002655793A CA 2655793 A CA2655793 A CA 2655793A CA 2655793 A1 CA2655793 A1 CA 2655793A1
Authority
CA
Canada
Prior art keywords
coating
medical device
wall surface
luminal
oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002655793A
Other languages
French (fr)
Inventor
Jan Weber
Liliana Atanasoska
Iii James Lee Shippy
Edward E. Parsonage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2655793A1 publication Critical patent/CA2655793A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/082Inorganic materials
    • A61L31/088Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30322The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0026Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in surface structures
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0056Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in wettability, e.g. in hydrophilic or hydrophobic behaviours
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/00592Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00616Coating made of titanium oxide or hydroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389The prosthesis being coated or covered with a particular material
    • A61F2310/0097Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05DPROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00Processes for applying liquids or other fluent materials
    • B05D1/32Processes for applying liquids or other fluent materials using means for protecting parts of a surface not to be coated, e.g. using stencils, resists

Abstract

Medical devices, such as endoprostheses, and methods of making the devices are described. In some embodiments, a medical device includes a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway. The inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure can bear a coating of hydrophilic material and the outer abluminal wall surface of the tubular structure can bear a coating of hydrophobic material.

Description

MEDICAL DEVICES \NIT11 SE~~`.:..:E~.~"~ iVE ~.~ONFI:~``~U
CRO~~~~~ ~ ERE'!`CE '~~O REUVFED APPLIC:~. I'~ONNS

This app, ifi.;at.t#.F?. Cli;fms p r"ioi'tt S' tt? US.. ~fL}~u'741(xz itE
A}7~3I3?~:s...ix;l .+s~fat{i N t?. 6 0,.'r8 18,10 1 Y2f I x::4i ~f: ~f~~~t. ~;.~,2i.Z+F~'~_3: r3-}t3C:
vC?~?~k:'.:?~. '`~~ 4 ~? ~ Y~~~c r.~`t ~,~tfs.;} . . ,`"?4F: i~,~
i.. 4r '~ ~3 r'si?~,.C.ca:
No. 60%S 1 '3, E0a w3.F.e;F fwf?i;tota.ed by reference as pmrt of .b.ts:-Fppl3'~='zFiit?I2.

~ TIi:C~~~ICAl. FIELD

a us :>fi i.nSÃL?A3 rUititS..s to #.a?..=df.cd devices, such <f.., :;:nF' z .
``
t~'t,~; ~: :~st:~>~'v'i ~ ~.<. st~ f,.as}.

BACK~~IZOUNI) F>L t;{' Alr t~~'.~.~14ti ~'i#FiL}t:`~ i:~.aaS z~ig~.14'i.f~''~~' :iLFC~~".Y.i~4 ....~:~:a.i~'.5., ~?''.~F~.:` blood S i;' 4f ~~; f:~i~:

~ ~ Ã w a,~\<.~,4~=a~'s~ .~\ ~L`~i~3C:_If~?C:~ ~;.i..:Z?fsl~'..
Czf~LiLE~t..=t~ c.=a 34e,:><~.ft,.=C:. õ~~;F.
C<af`:'1pls , fl:i p.3. ~.3`yti t.,.3Ã: a3c tF4:Cif:ldG=d i'7y a t:#.T#et?r, i..4t_.Ictot. b v 'ca i liItYFE's or i.v..a1.3 :cE~.,.d b?i' an a:i3cla ?y'8m. W'#3Gli this <?t.t.un, t.~t1c.
piEssag4v,='F y c:?f'. be =oor 4.teF.: or :Y`.f..1F?fi`srF:ed., O`.' even replaced, with a medical vndl3pf'C?st,`f!.=s14. .'S.F: E.'I?taf7pmus`s..,.4sfs is ~+
3.v i-}~cal+ ci o.Ib#..,<tfr member '~iri ~ $~~ F;~ "?h.ifG, t the 5 11] a 1-LF3?~.a=~` :.1 t;~~i?L(~'t~vr: ~; Y.~.~':1_~;lf....~ ~..
. .õ 1 i ncloprosIffi..ticS >?=3+õ.iudc;,;ei7t4, covered :*t6.F"1ts; and titezF~
,gp7ft:`e.

` ~ "~`` , ' , ~ ,r ~.~`L.f?i:~f.f;~t:rt:'c~L;: i:=x~I.z ~?~.. 4.C:..~'e~i"ed~ fI15id~:~
.~?f::fC}tlr ~'~ ~~ a .,.f~Z;;#:i.=1+,.a, that ti.f~l~~z3, e... miZ`.
OT t;opro4,.bÃ...is ;F. ft Qf}. f3p<3cted or if.,dLÃ.cid-sfze ft3rf1'z t.ae oF'Fdt?pI'ost,.~f~:s`s :', :1"a7:~po3.'ted i:t? ~.L dv4,.3 d.z 4i i:. 1-3-pt).1 :~.'i3i.h;klf,;, the `~aF~Ãi. ~~Ir ~:.F't i?~~?st~,LsiS is .:l~.~~Jc` 3C~4~a, it',., i,'.~:~tf.F%?=';~u ?3"
V ) alknvod ?,.xpand, so that it can Lt.?2?ti1'~4.',f the walls of the humLn, .~~Y~i~(?~?af?4t~is:.:si..:i:r can be f.:tt~FtB,.t? t.':tl3 ~~~iii~:,C?:?1~};?i.Ft1C~lC' f3:a.Fi'~=...ziAi:t and/or .,.~i~`~F~.2ti~t'.'+,<I.iFC;ti.
!Lt 'z~>;::l ~ ~l fa`~~, ~ = ao>:`~t,. l`r ~. c:fF 1 ~ ~U`S%l: t-Fr,; r~_i:l:
i ~~ :^ i#F`..Y}d::fits.

SUMMARY
The d.isGlt3sE1z4 Ff~lLi"es t{3 n14dfcal dcv.Fct,.;, such <1:+
ont`t?p"sl:wk.':^. T,.i<: ,a7Zt=;`:~:~.}~i i.5 F~fc.'*.?.'Lz, >.ts.:'...tttz~::~; f}af xt.L?k' tf.FMi+'~.?~`S,r~~` ~~[Ff `+i?GF~f.F~.i.Yj +. ~:G3`.F.k-.~}r~}st3~4sL-=s.,~. ti, > i4tarCxph, zfc ;3F;f.i:=oF' hf d.F<tplai7biS. allows .. fEfF i;t,7if.',.3"i.#fi<?F:
i5ft.omp).Er .?:.

25 b,t;.f?:i?3e[.=4FE+'.; ooiFt;ng P.f:.terns i.m., :.he Ã`ndop..(?sih$ aC:s, aa a?>w .3:`ipC>E:l, tl'$fi.'. daS(.'=i{):ii.art, ~L`=sFtuPes a medical Eaek.`:,4,.e ?:t:av1 `#g a body o F:.3ts .uF;`.#-moot.f;'.ii. D?aafds and '1:onmt,ct(?a`a' fo# Tfi::g 'c~'#?
elongated +iFbCdicar Struci.,F.e, lu viFag#.?n F.?i)t.>r l.#.i7F.,FtiAi WSFil `uFfa4'* . 4Fl:ix aII outer 4Ez?l.#f71#':1c1l e ''all s.#.F"ak+.. and defi,?Iw3:; a cL'#:\.....a 1UinLn, \ , pa;."3gew{.z, wb+.:Fotr, tbV :n#iLd 1t2mna1 wall swT,~ce a.tFkl -si\ac "',sFal su,fa4'c c.:A thw.

F?.3,.3L>~~ i,La a:l'13.tat,.i.tf33_5f4'333ii3naf i:`,aF..s4 e.aG
pas:6e:~gmv"e.#y ^:h'?:sjgj7 0=.Fc tii ?ii.laFÃ~"
structure iiiei33' . C:1f hS'd-::o;-~IhFl#4: T1>c.lLi:i1aJ and tr1;
iiaF~.`s..'I yF bll:a:a?1":'al wall su. .,aL:=f: of :hw tubtF:c:.,: sti.'#.ILtF3.I4 bC'.ms, a :;t)LFtIn={.,~ a?f :mlÃ'iF~"'1hF3b'#c n2c`:1.temH:1L

?#i 3i>C;,...,7ui:: anmy #...F ut1e d3F'id.,' S`r7' rnoSi: (.1f the fol.?"'.,iwl.n ta:,s.3tF.?Ã'es At Fw'ia~ei o`:?e or SE:lectr..d3 rl ~'#i t~s of ~.tf .(~ #.Fi;~ial c3F7 d side Z~ ixil :~i ~'.;i~+.25.F..,s of ~v,.a`
~. =
I F7~vÃ..ii:~t3l dLy#i'.i..; ci3f.e ba.i3A c`'.# CC3#.ÃtFalg of h'}dF'oph?l16.' material, e y \upe..f hyd.Cipl~ffl::S,. r..F.at'~?#.a~al, r. 11. .. Q:: if L:#id :.#Ã'.i:ll a:#;.id side vi}r`,fEl st.1ra"r.@S..E;k of the TI1t:diC:al d.vFcZ', uiF;l bear a coc3'#:.11:g of .la;rDt n:;p}F?..Ft mz3, rF al, L' supei aydÃoph7liC material. At least one L3? Y?::? 4 ,:ic4tM
:C~F:3fiti ?F cf P~3 ?taÃiA, 8;3rf~.L:.o- of dit E~aL+~#a az E3~G=i'z4t CaF?.
4fli' a i~FtF~`~w of hydrophobic r-f~1z3tcrF:31 .? ~ rf ' tliatF: s.:.d?t.?'~. ~ fa 1l 'rI D= ~ Ye':i. ~G
i::Z3.fi bear . ~i>.t~~` ~3 3.Y
:F~"r~.?.FIF~?i#:azk~~ ~1FC.~~:~.~L of the I2,4t~.t~.i; ~ ~ 3a :'i3~;
W .
hydrophobic ai 43tcl'#:'r3.1.

The coaf n _g, of the :1n13nil side 3#`.{~a ablui7;#tle'?l wall sF F fel<ti's can include _ ~.
k..tF`l::E~~ ( 1> \xSFi'. ~ .3 (~~.1,{.,~'t ,i~ z' g. titanium i~$E3:~S1('3F..
~~.Ãt'Ã..F;c3.FI#i t~j Fi~..e~w (.x) +.caa~.
11_vve s. F # ysac`.l:???L' h$.FucF"lF#'::.'x u g. t3f: in a#3 c#.i#.ato>e or 7'EFtflG pzxi3w: _W#l ?#'.:,uuF

oxide Q.N x.) ~ l.C.., be in C+t.a aFniuqph1Zus phase. T#}.u#i?m(} yt oxKZSu..
(-x) can tFc. 1niF).2 ,ai<fn Dn.' 20 phase cd1m~:)i>wd :t,..#th at least #3?le of fliz fE3flf3whig phases:
,.Ifi1z'., iz"D'ook_i~~:w. I,Zt?F`JLl#.1Ãv.;
i~#i~C? ~~i ~ ti.#Fi#,:`~.~FII (. ~ " ~'i S3..C1~`~.'. { L-ir~ {.1~ ~. and :~#.i.iI,.FLI?:' ` +' I i?xii `"~ ~~
~a:. ~:.i ' ~ ~, ~ f ~~ , ~. . F>:;.iF~.F#~F?; ~ ''i~ 3 [Jx;YbÃ;-(^'x) E.,i.a< be :.:3.1Gt por#.:?us, G=,g, i"fl'v`o'po.`oLIs o.F"'#
A#i.:."^.'o-poFoF,:i. 1F.i.:aTaa.f> ..?}:idL?
(-:t) Can bC uFie s;l}y S.F1iL.~oÃl i.L., Ã'#":A #:liFl=Fli pt'3TC30:s, II?, addÃt13.3n to >[1t, i:ti.?x?t.El':? ` r .;) oxide (..'ii. :he ciownih can 1i3.clude phosphorus, t;.g,. F:al7 to :?% of pl,-,i_3j~:.~ho.. w by weÃg``.i:.
5 ;Ã. addition ~~ ~~ the tiia.iii:iii-~ t ~. i cfxit~~: ( -~.) a~:~;r~.~~' ~-~E~.~~s~?1.~~~,-;~.s, c~.~<#.t:~~~; L. Ã: ~ii:;~~~~ie >ddÃ'.:~:>.~ t3:S:$ck ;3i .F'uthL:=n;.um oxide or bo(tF. :#~.'s'#.Fl}.um (+0 E:}5.`zÃaf,~ can bi.; dop f with at least one of ;i, 'roi?o'tY:13~,~ Ã`=li:22entti. carbon, 7?#:tt'is4:;;3., btsia3tf:ffi .x:l ..Yõ~.;dõuTfb ~.' . =.
ca;, be doped ist::h, bs3t`ii b.iS:irf3:h md i;'zar1adFi.3::u< A lz:ve3"of t_rr?.FrEiL ~t~#~`_=A?t} l`s'~i Y tg., illk`v:?
:iak -mt;, itFy: \ihm>~' mad/t>z ft.it:.?.ii.?zFlz4.yl s;31a# L:, c'r.#:F~?, bi:
~~tcp<?;.,,fted tweF .3e 1') ~3 t#,F. S'3a.~~;;.FLiÃy examples `.{f organic C:o1:7pol "If s ha.. can be d: A-ZC3sF.4 :a over the 4 o.3:#F ..
i.FfL.AL2s``4".= oc+..3.iac1.4i:iDi3.a17ir and acid.

1 h>< i:~.Y.a.~ing :~pcxÃ: tho <~~~unataial 3vall ;3urike :.,;u: also include bit>n?o:ec;.tlÃ.s, e>,~,, v. .
-3rl.P ,lra.'.l. Ã ?n? a ? s C?lyn ~ X > ~ =,, y ' ; a L w"' ~ = :yk ' ~a:¾F;?~: x 'Ã.1~,a.,:.~`~e%
.F~.', ~~ a~' ,., .F v.,_ - ..
:E

e~t7`, G#~?lÃ:1,3>?x,3;#.E ~.i~ aFl~~ Ji#i'~`iFE<~' t:F~, ~ ;F~.~iit ,Ill`~~e~.ldti . = an Ã?I.;~..,i321aL solvent or a .3L"i~i':i,phE3iSI:: HpFd c3~.`+s.;.:e, a 1w F,.L3w:#.`z~..r? ..Ip¾3.F;. the ti3,3l..27.Fnai wall 4I3rAuE:4 c.&, fitr.:41Ã'LF r 4`y:; l`rAõd:.' (? ) Ã;.{3..Ãfi3::gii b.imc-slCt1FiE! e.g., ?IiB.tsiul2'Y dFÃ?x.1de coating with i?i?z`.1s?.,ci~iliv.S., c-an .dÃei'.lF.F:ÃSe i=(?x'ld l>v~"-,f' ?3. t:.t a,? [I!a'A i } y,1 oxide ('?s.)5 a.. g."
tF:aFl3ldF:'3 d1{'s:4.Ãdw.
The coating upon tl'~e k]'31 ;3a<z iii2d s>d-4' wall surfaces cam :~>: ~Es irclu::,c :
HttFn:?F:'cuzÃ's v g .

T..e t:fi<1th1iz upon t1:f' abluminal, iF.FF`F?i31,':;l. aI'ld side wi.lF
s~.~~"s'faL4s i:".aa,, iõ1c;.iido B T
'molieF:lc ot the abluini..Fal wa1:iu.f..e eclafitng c<~rl ba, of a C:3:ff ~rLnt fzÃ?3i? ? o.iT.I(.`lv,cLlles of ~'tbi li:~s?nF:'lal <'kF7.il sFd"L'.'wa3l sl'xlwc5;;_i In .>nt}th.;, as ~~~F,~t., i~lt'. i~?:5:~.i~:~[lI`S: f4%;iiFF'i 4 Ã~..F-IiE'~.fc.Fl ~._ , i's>~L }?. ~`IF f a ~Yf}f.iC of interconnected i,m3d-, F#.Ã' connectors %or"lw..lng wa v.:: .?ngr_Ftud tubular simi.'.=tE$..~ hi:F` z ltP ;:21 7?...er luminal wi1?; s`ii#`"ttl.f'e iÃF1d an outer `.bl#.1#11?.F"f'e wa.l s::erfiÃFC.tf wii1C, t3z3wfimFng 3c.:`s?i>'iil F~f iLimun oCpCd s1r. gc1;'aX. wi:d'.4'}'VS.n the inner Ãud2AD2TLYn wGFS
sC2J.+.iYcc. 4itil,: 4x"sid~. wall t~'Tn wSeV of the bands Fnd ons? l'.tÃiI s iLSi" II:I?g, tF'i!i'isG'S'.I"i+' passl à w:ny4 tbIIzI." F.hi: C' a3Ã1c :.S t3.'..,:~~'Lili3$
strucwua. bt.E:i"E? i;oa E?Fag i?f h d7'o ph Zkb iL:-mkllmilI LF3Fc_I ti?ti cFFa`"'a.^ ~ 5 3 l,i.~L: : ~ s F F F?: o o f :ho t+.x_~b~:lsr st: "LrL~iL2.'i'~ g ~ v a t~ ~'~~i a.~'` tF coating e:-Ft:~~g f.?~~~~~a~~~.i~-~fpl>iliG ~~~Fi~..~iz~l.
r .~731~::~E}f~.#.rnv,`r'sts :~2<~.~~ include C:F7~-` ~}I .F13E32't of the fiZ.~b;-~zL31z?~.? I`~c3tL.F`<:t.

20 At ..i9'ciS or F%3i?:Fi xt=lceted I'E'=,gdi?FiS of il.Yi lE:F:1l':cil <3.F3., 41i>G= wall s..3.ffF;::fõa of the e't7t i3ià al Ã'v Lc i"i ~>~ ~ a t:;Ã}ci~7F"F:~ of lt~'C~.['~?~?~3Ã?i?FL ll.::
t~::,'F;.~~. or i:li~. S:1"~tFF'f'~ lÃ,..i?,,..i at...~: sii>~:~
S:<7ll iti f.,3C: onedlical dÃ:i~ica.: can bear a coating of r'lS`ai# ?~?;3<?
?Ft, F7?ÃF3.~FF:F3.. At let;St Ã?,.?e or more s"c,t.a~tE'd rcgit?z?.n i?tVr3Sv abluminal sF#.Ffi3Ã,:=(: of the n.C.dÃa..l device cc;-a: .7ew- a coszttx1g of1hS'asFophiPic. xnaaa>,s.a, c.L:?,, 4upoÃhydrt?pHÃ.c material, or fffic. c;'Fti`.'i: z?..?b, `."?iÃ:ir2.E

.l.5 i=1=Li.l surface o.". :a?G.Fxdv.~`.F.e'c3I dÃ;'a;t'c can bt'.~: a i;i?at]n~.f of ~'3~'%E#"C}~'.?.aTF~~A1z. xl#."c#.iC'.`~.ci., e:~;.s 3, ,{ E
.~~2`~ivc 7:i,'~='1.r\~~.?i~.F3it;~ :~3t~2~L4r:t~iw.
, I ;e co~ ~inr,g of tho ~~unffial; side md abluminal w:izl svlraacLs ..~in inckld`~, tÃ.om; mr---:

(~~ ) O+131s c \" L.\ 5vf=. t-iLai1_FLim dioxide. 'Z (&a32_FZ31[?i <-" y1 V.\IltFv( \) 4i(rl Lawc +c2. y1'L>=F)..FI?e stLw.L.kua"e, c.g. be aF?. i:d?t anatase or F'l:tFl`t>> ph.3tiL:=.
TF.uEFe?uFa? ( ',-y) L.x:de (-e ) v.<.E.:d bC: Fi.? i:f13:

~: x3.`114?i 13~:! >Ã3 pi?_=--, Titanium ("i" y)o c3d4;: ( X) %'<iitd ~.'+z.', :F$i c3r; ,:ii3af.Fs.4.= ph-.,:e . v.--t`_.~bi.lwd w ;;l z Ã3:
?C.'...? i 0-ne .5f flh+`.' ?i?l;Ã3Y'. iÃ.{- l1~.i:*Ã's: ,..F~'.ile.
~#FZ>i.;~+rFt`v.', ~.. ~ e2i'1.. .Y :t.: zf ea. il#~. E
y, ;~3 ..:.FI.IS., <?.'iSci. ,,~li. ,!'>

~-~X-Wi? (--x) (1:), and tltc$lli;:I71a (-j-Y) o?s1de ( x) (H).
TF."1e3.Ã3lzf`s3 i;`:Y.T,&: ( .K) 5,a3's be ÃlzÃ1{F-p.?f=(?usy -:Yte;io 3?<?'`>us i:' .",?'I#.ci'<`,-poit}Lth: ..F.taniE#;a3 (4y) oxide ( .'i) om be pnvÃ`%1.lly 41?L?oth, .z s:=.,. not f.3:?u<?-pt?f'z?Is. I.7: addiÃ.toÃ, io the ?ilaÃ1iu:1'1 (1) oxide ( x), vxlo coating c4iu ?,?c?ud'e. 2'?hOS~,~I'f.tl'ls.: L g.. up Ã(i 5% of phosphorus by weJg~`~'#.
IIL, cadG?'.it3Fi tii Oac E3Ãini.um?.
(+S ) isxidc {-:Sj c;"3 `..`3'? _' p;7oq)boms, the coating can #.:E
'A]d.F3:T: C}.{?.C>.5:: or tl::r:?ea?:1ET:'.:
im& or both. 1 :ta-:[?14~,.3 (-`-Z) oxide (-x) can be dopvd w$~..ia at k134i one of Ow 1:13l,txw#.mg a'aLÃ.dwm.t5. iron, t'sl'=e. x ,. xi,. ?~.> .
`~t`J'z, ?.xt`:")~;s.'Ã~. ~3e~'1`sÃ~3~~? and ' ~.t~;?~~b'~.d~'#h, ~:;F; , ?
t;~iÃ`: .~`~. ~a>3 ~
t ?e~; ~^~>~;.? ~ ??-~~~
L'+.`ai-nuAl1 and vim,,dlll1um. A layer of l?..gin'a~.`i.c cCs1axpow:d,, L.23,.. 3lfiy3 :4 =int:, t`, a l : i.aF?e < - t i` ~
~:cla'c`3i .{.,?.~,. i_r' ~~ r~iikCt .7 , :i3:<32?;. ~:~,.ii ;3: deposited over the i=tcrliEiT' ~ = Y') oxide ( ! ) ci:iwt:i3i7~.

i. S~~~.(:~?'3t. t.Xialt'1p~.~:,4a. of 3'~;'.i.?;?~t:
i,:[:a?~?E3..:~,#:+.4 that i>:. i?="'N deposited ~)~'r>`. .ti~:
:i,_t::7:~ 1.`i+'c.~1t~''`, <? ..ai~~~~ ~ifl<:":=.o iliii s`?cti$dC:e'rlp:aos-Phi?n1c acid.

11fe a%:t3 1iisj .#pi, i Fi`v' i3?~`km.6a'~#ax mkl1 S"i.ifi.t:e can 'c#.ls(`} .iÃ"cil.'.d ioi t i upoT. the <lioiw7?,.T1aE w;.1,l s1.ffiG<`s' ttt`3.t`2mn oxide ( x} i~.':yu i.Sr with :giomi?lC.Z,:wli`.'s. c..g,. ~itcaiAlam dI{.m3.`C` ti.i:)clti:lg, v4`id7 bIf3m#9le:L'~Iles, caF? I:x"cl$`sCo-G a Jecjr.m 15 layer of titanium (.i-v) t3.-,,l:lie (-x), {.`..~.t,~,, 'Itltan;:'LIm d1C?xide.

T.L. coating 'qt?n t11e ..'~1mIn.:3l and side w4f: 9ur-t6 us can t3hs,C? `.
ilwhuh;f.o b? 1.iZ ~?1.... ti. i..: w:i3 C: tt L t x y ~ Z,.Z c r~ n ~ .<. ,.C.._ _ C~-C....,e,a.~~`3~.8~}.t~. .~ ~~:t..,?ls,'~+>~:. ~i:+`c;
:::~, also include ~i ,~~tnm:

..sb~.`n`:`>-i3 st3''CS:nt;). The coa:lin', upon he lt3m`.:;l:i, cm:C: 4.d:, m~`e.?t`

.'`,aw. ~ ",~:s S..i3, c? i<z, ~`3i. 3 ilFL "7#dli.` ~: `~~~ organic 5~.~iEZE:~:i or a *¾?'v:f{~?~ ~~3:>Ã3i. ~` ~ ~~"x:lL. 3. ..B: ~~3 ~-~J<aõ ~ .
c.+v.~:"~3t~, x:~lt +,.c. ,..sts..SF~

20 GIa?o'n:t ttle >inii:>cil i`=Ii?is side wall surfaces, C g, tit:.`iii3lun.
(+}'') oxkk ( x) c:fcfinw ZO?b b3tDnn<?le .t;4.. ?.~ tÃ$.c3a?.f.l.n dioxide coating w:1ti`i bii?,"iol~'..L:"'.15es5, t:utfl., 1`1L::E.i:se,.; 'sL.G,iil:?t~~:~.
iay`~.'y of bt.?:I>ul ? l??i ni.'. c 4?.. tltil.3_:`ah?'1 d.<',xidF.x..

a.S.: Z?,}c>t.:.~~ "u-Pf3n t;.34 a:?llaT.11.ltllv tiUF?k37.i?l and s."tdcw<.lA ti%ri,xct'.ti c<i1.. .~il+::.'=.T.R.:ac b?om.t>lmfles, B1t3mi3aeL`~ule4 of t~~rc abluminal Yv'-aal 4uifa::e coating cm`i be of a d1ff~.`#'~11t 25, t4pc .:_~.3~WL.~ the \?iomok'V0..Sa `iFi the "I~.aw}2FLa1 and :1F1fk wall ,S'u.d'Ni1Vs co.dti2~:`a.=a sa,. l.??3s.:3;.he' aspect, tht' dihcl[?s.t`S,:ffi;~atureJ ia#:lf.'t.7.od #.3f;?aoduLlxs.3'::a a.?E:2dzS.~~.~~ taS:v":z.
::?i n3effioaa Inz2v a:g the f3lli? '1ig (#) c(i :2x tõ wc?.lF `.iu:'f .3.Leti of a a?ed1c:]1: dei.lcc hc'2F'#:;` a b'E3dk. of S: :1~

i:?..i :t.:s <:`d co1'lna.ao:'<s R?i'mi1lg an s.iC?t]gi~te~ tubuhuF
3trt.ÃLuF1`i. .i?iiv>1iw ti.s~ ;:1neE luminal i^:'illt :~ + S.3ifc.i ' ..3 i:x? OvAer i.l~lumla: l 6t i3:l. 4sx? facE? and defining ,A central fiu.llZn or pS x<l5;Owi#3'`
W
hefti:A .?i; xnnerl:;~:F71#nel.l wall surface and SIdC w:3ll st#. f<3t`4' of flne bands . .".+:.. .<=:).3`3e.:"o':ti t[~[15 } ( y ) Y-i .f.Lt.~.a}. l4'CrL'i~~k ?1~tdsi1 a4~'4GA C~s L~~}.i~~}l.F~fC~ the ~..`FS.~:3gCAttr~L L ¾.~t(i~~~al umSctum wSLh rC,f.?A.ISE'i.' tiuuaiw21 (f'y) a?xIdc ( i). o.&r li::unit:f'?5 d,.f3Ytde;

Ziz, .;:~:3i?sÃIlfw the device to i.. [?I7i. .1tl`e`tt>s sfz.a::U.Ã.T.t to C.f...sf-r `hw blta.tlai'r~I?.
~
oxide #. x r ~.:~i~i3.ti`~~;~ ~i:i`.= ~3`mi~ hril,t't?~7_d~it3hFG:

Cifl,~ ::='Cix?slf3u whzett:d surfaces of .hF'i3-Ii:dlC;ila device to <:i:Il3..Itz.iC?I?: 4..~xfacie('It to c:.f?.dStr the Ã.ii3.nt.:f2:'E (4'y) oxide (-x) coating tir become stape-!'hyi<rC?j-pb1aic; <S:>:d O'< ? c o.a 1ng tFx+... :3F'rAici'3.: det';e#:. in a -fi1'st s?"`+.t.lti{xnL
compatible Wi:h des~it..eCa bl Ã5mirli`cul:,s.

..mbf}dTmJn',s may include one i:31' lilo3'i= tsfthe ft;i.ld,wlitg ie'aturt%s, T r~u~ {:-Fs. :'(.rxx.ft:on Ct?n be i?i?I?.-pt:}lhà f.=si;?C?l4Lr. The first solution i:i":i. .I?uaudc a ~? s. ~. t~`
d3.'=:ii3'f:,d b#mn`ae5 L'.ci.3,3c,. wrp.i. 11 : `cx:sS.r` ~ l or ~1.,'~,3f~fr.I~3. T'~:3 ~i'. ~~~ t ;~t;<t. fi ~. rI t..~.a 1 : ;ht> Ii.t~ v ~`
a p+.?l)-ne= L `:,.. ~5i~~i'L~iw'EL1?L f3 7~t?~? a ~'~~.Y7t ~? it~I't11G?{. 11C
first 4s;3lutii?? Ci.a: ?nf;'lE..C.Z ~
hid:'i;phib,c lipid ""TSule, ` ,3e i:' . si;li~.af}`? iclT: ii1i luf C' fa a lC c1St E3ftt'pt?li:Yi' 4olvi ni fi3 Ãi:C:

1>'~' ~ +~` 5 r~c of ;.z?s' ] )fy2F 2s kyR , ) least `t~ ~t.~4. ry ^`]~ ` p ?
r <~~ r '~~ . ~F f...5)r .
.~ ~ ZS Z-~i.~+.~i..3tr,~'~-}~3 f.%S. 43t\:3l~il~'~i}.l.:i~F ~i-=~r.St=L..LLA%~ at =~itdwTL k>tltA ~l'f:~dv:A ~1..2~ 4~. ~.\.=\~~

Ãtl .1t;hc.?te to tiiae >.;c ytrpfif~~ie sutl"ace, of tt,s.. tneclicFlA
fle,~ict>. ,,?4 solution \.~lte Ync.fl\a;.= at om E.`if,::wiC~kl-=~r~-~il.. L.Zi.~~9~?iiCi(~i l'fr tk'it..~~ at least one :sf_~F~~i',i.~itt \+ g,, t~,w.~.:~~
~.3o2i:f?lecf.f:e ~
s;:f3-~;~.1.t:~~lL; Ai~1t., #.~e~: polar s~fl~''i.nt r`i.Tl'~T~ a second ~~?1f3;21:~.~,~:~'.;~~i:= ~=i)d?.^n"~:c.i.ÃJ2e irfth the 32C?~~z"
pi3a.a? wtra i:::".]t'. . .3t' fis`~~ hF{13?loli;%'fxle can be hupii3`ln and iht; second b1i?I;3EZzf.=:;=-ole +..:.iF3 i3o ..~..`~'. pac~~taxL.... .. ;`.34 first solu4#:on can further iwf?inp%15fv <.lpoAym:$V

isc?bat:v~]enc-b. ~c.~). The fins1 s-oJvaion can ix-ia.~~~~~~ ~~ydrophobie lipid ca,?su1cs Coll.i.iÃs?lFzg bii?.1'?o,es';:u "vs, as Wela as hyd.M"i3phIlic fywqps.

1E1fr 11:0#.hi>d Cc'sll haZ t, a further afr:? of coating the medical device in a s,uci?n:ia at3lutiof`` tonnpcs.1~. ie 'Ly'iFh di'=S.FTed~ b,i.`ia:olf,.ClasC'..>. t'he vot;tiflli: st3Si:lfion ca#., be r`:oAI-;?ttliis or 25 pwzu {A li~. 4eca.,l.~:`iolio4.ion. cmi include biomolecules, L g:..
p<?S.i.~~~xel :Zr ,~opa.+in, :'lir:.`.
s -ovond sl?lÃ.:a1o;.3 can $Ã>i ludc a po[4ui~,'r, Thi.' St;vi.nd :olu>iL?~';;~
can. InS lu:C3::;:3 hydJ'4.3p.'.?i>i{.Ãcl liA7td i:<fp~,,Ãz:.e, 'lTi?.t: nlE;thoEi f.;:;:3 include a fua thd::3' step of coating the F.?dE.f>.ki:al {x:'o'Ft.c of 4s+.p (0 W~th e:o ~ ~~a~tYa~..A ~*. ?7.~ ` -~n11L r`~?<i r.:1I~.1~?'td;'Id ~:..~`~,~.,., alkyl 41A a :~ 5 `iati~.L= =~=?=3. i..~" ~ ~~t.F. .?.~1:3w.
si.E~
~;iiC~.,', :;4f`t=~ wa < ~~~~ e:me:

?pe+...illii:c%t.y,. ofi i ad~:.`~cyl yil iint: l I' `>~t=~i]i~L~C 6'~~~ ~tt"~
it1E?dt: c C 1~.

"qw conditions of step, (ii) E:an i:ricluEic pi aaE:=ing tlÃE. n:L.dic,;>
:Iwvz;:e i.i the dark e?..Fsd==<`I ~=L .t-}`"#.:bbinÃM. ~he =E3I?d1t3;f:.Ã?'13 CÃf step (Ãid) can ?nC%hide fli11;?lF'kÃfi:lg vta.i11.C:i.s i4, th<:
?.7eL3.lL;[ÃE {.Ãev?Lc 1hr.l:. bear die L+ k:t.Ã>?g w?tl1 iflt?i1vlL3lEl.
light. At least a ~eg:E?z7. \?:i "ho 4?...t?ffis33. and : i.Ã.:5: w'+.'Ã.il 4uÃ`fi1E.o-s that bL.`[?r ths =c(?aC3Ã7õs~.f, tiaÃi be 1.Flu':?#Ãn:?.ted, At i,.GE:;i, z3 Ã r+,.giC?Ã.3 <)., flne, :aE?.uE:`~1?:.e~l W:il suA'facc tl'1at x)e3:e8 the coating can +3L= :ilE..lÃalifz#,t a'=z. St, i3 dii) F.cÃF: E?lsE;

`=i<: ..... v ~ t~~ :r ~ 'Y1..?~~
~~.u i ~~t?3'? ~~f ~:.,?.ÃÃ'~. :.~Ã,a:. zt~; =~:= ~?~~.4 IÃ:L,Iu& Y.x..~~~ti,si.7 ~ <~ at ttut t ,conL3it3i:ab.. ?urlki?'{it for $.lie surface Ã'ig?.on ii bC.L,C?;.T1e hVdtZ:pEa_s::?? 11 S ., by 4Z=O~~; Ã'Ealbbi??{-. 2 'C ~t C i?4,, t ~i.:t ~?'~ +~3E.I Ã>4: Z~ +: a~~i' ~7i.:~, Et,4; S.~': ??> td'1U dark.

~ f~ , i'+aÃ?.Ã ?: pÃ'a?w~,s of ,`_*tGr" (iv) can b`, d'~,pcoatYi7g ei<t~ ,Ã
iiS~tt i~ ::v# .Ãv#rw, k:
~{à .L ~,.Yb:'t.<3:#c 4i`.i3v .~Tlg El t 1.3 i35p1Ã?a?n?l, ?ÃÃtl$3 S' ,< it~.a ,~ + gw ,,' c~t r, ~}'a.. 1.>.:.:.a.~.#~i?~z :Ys~L~ (-x) t~E?EÃ~ d?` i:i3:i] ~, ~G :lt .~#::~:f?~ L"ÃE>?aÃ..L. ~.~,?c_tà ,_Ã?. The L=C`>x:MIÃr can h'swL. a cT'?v'sYi.aiaÃIlo smFC,t1#ÃGr i?.g,,;.., bc; in a #`l3iiÃSC; or <3?";..3.tcu,;c phs:35:. . IErF.Ã1 :#.m, ~ zÃG.~.ÃF? E ~},.:~.gE.Ffi'. .y , I~e3.Ãn ~'~i , C.t ~'".,, <~ Cti,~`.3. s.i4 Ãi? c:S.Ã# ad.^,4ÃLasE::
ox.dC. (..`4) c=i:Ã3i bL. .n an aÃm3~F~Ã`4<f:tis phase. e phase cCiÃx1bi~3E:d `v6'ith at, least one of the IS.3lEoW.7nx p.?.Fi..4t's, ruiili:=, ?,im7k1i:, ÃS.,o3'..+-FL.i:n.Ãi.:, i 3 ??Ãf?q?}?ow t. .ÃEGa?:Ã t? ( Z' ) oxide (-x) (13), and i:ita?Is?1Ã-nn (+y) `:1iRLlE.: (-x) (a-:~ ~ TÃ.,[ m?'tFe?
mud's'. ~ 'S 3 :=~~Ã? be miiTlo poz'E?ll~,,, e,g, .{7ei{J or T2 ÃL Ão ;si3.Ã'etu*< ÃtaÃA`. w? v } oxidE) k; =F:d.Ã
:?8 w.Ãai.'xc.-~.3y smoE.$th, ?,a:., not nil:Ã'Ãi; Ptl'i{31.m zn "e':ddÃtiigÃ'L. to ffi.: FÃtaÃ?.e.E,?;.i dioxJE3e; tI1i.~
ci5aÃÃ'ÃÃ~ ~ j , i ~. s to 5% .~ `R "`4 ~,. ~ ~~` ;e`,Ã, .
lÃt. .~., tÃL..?.Ãt? ) Ã?: :~
u ~7. :z~i.a~.,a~4 ~ ,x~E ~~3~ts.>itÃ~, ~'.M, li~ ': o of Ã}Ã?t>~~~i ~Ã.A

the t3tci`a.?1.. t,.# S'Ã-i3 ??:1d4 ( '= . ~~ c$ilYi`a3Ã rs?`Ã63s-D:'li`rE'us4 the E;oatiFlg 6,..ÃE? include ?aõdiÃ:?~.m o?,.ÃdE`= or ~:. 3'.ami'.Ã??`izm ,) midE' or bE?E}l. Titanium f? oxide ( x.) can be doped wÃ,.h at lL .aoE o:Ã7C i3z th4~
feH{?wti?1` c?( fnY.Ãzt:?.- i >)`lu carl;3cm, 1..Ã.tr(:gen, bÃs.-mab and t`m,?c3H..Ã:?"P, ~.~.. 3, t.,x<E: be di?:?el.
'4vÃ;~~ '~:;jt.,? `31.:i:]?.I?`.~s hÃTl. F <Sa3.i:C~iuF:2:t. t~. l~3i~'~LÃ`
of E~:37#y .,:6,.LFÃ,,~~Y'~C~?`ylÃ~..5~. L ~;., a.~,.~L l `i`.~.13C., ~.?"~;-3 sisFa.Ã'?u and i:' _izi..o?"}}..ilkyecu xbe dzpL,Bif:i.d over 1i3L=
i?$w?n3al"z t$> i`s:4Z>~' Z-X~

i..fsafitlgSpz'>`wÃfic .::u7ai-pIE,s of i::l"~2kÃ1Ã~ compounds that can It?e depi.3Si`..ei over the :: ~Ãk~ ~~ E~E~ :~~ :~Aec~=.~sil~Ãa~.: uà .~~.
E~~:=t~:~le~=~ri.~~?~~s11h1~r~i~ ~t~:.:.i~~~, i c ~ ~ . ~ . zy = t `
3?t 13aati~?t d?S~.lC, ail?s; ~?rt?'vÃL~aeS stents 447t..] various ~
~.tatez:Ã1s o x ~: IaL.~rhobla; a1.~.
ilyt!Ãt5i3h'{,.ak coating. ThesEi Zt3a$3f1g P::1tt41'Ãas allow Plt:i.E.mczl¾
of various bÃ\?:T?t?-if.'>w3#.Et 5 <.3?1 .:<iÃa8 =L~;Ã3ÃMS ??~A'c'#- StE3~t E j Ã~~?:Il}f i à i t?33~~l~'~i. ~?
i3#1":{:3lt=EÃlC ~?E?~~Ã<#~`.M on s`i1?,.s, ~.~~:Ãe dis4loz,,E1#.t: .?aso provides methods of gE'Fie<?.7.txg 4tu,?ES xi=?i.11 such co?1 pi::?: 0>.3aÃ.3#:g and/E>a .'`. `k`.,=.t^ ,.
E ' ~>, a.ts.

(~

Tha tel`>`.z1 b.:ca?a#lt;t;ltlc." as used hwiS.::#1rcft~I"G to chL"Ezic;il c'smpisLuads. ~at4}~; g=Es'i#~
s2~.:`.Ã=a;?, dru;7~i. compositions ard L:l,.z: +.xz;a-t biological UDlQ;is o.ilÃ~~'.nvn;ie dLfiI.cd. F$ll. `'.eC;b31i['<.EI and wIi~n;ffic ..',nns Ãts~-.`ia he"cn i1F i%e the .. iat"f3e me..ia3.21g as coi13I'no>1l} wndeI;sito(:zd bv one of ordinary skill in the a:;. :s3 Gvh#.6.a> this ~
ÃII'v~.'nt>i,n t~i=~,t ?~. AkthES`s.lgh -nll=fxE3ds il.Iid a:1atoP'.ials sõnxwli.3.r or `~''.qu#E'i3.lf:n'y. to tho`:`i.:
de, 3b`d ie`C n can" .zL` used 3I7 tiIe practice or EcBtIEzg of +11Ã pta:.:ie.lt t:E uet`.. ~~:'; 5.3:1~t#:~~:=
me}izr. s z3r3d.umte,lals m;: i>awribc:d bc;lmi'. All pubhc~.:io, S, pate3it apz =.,.,bti,,.r),s, pati:.i7tC, nt3 ?t.>er ?1`v,.I LiI; are :lt?.E:omi- C?rc,i.eti b+' tefei"i.a1..,S.% in their .:x f?tli:I'L;t~'. I~ : z:':;:~~~6"`L~~~iC:~', ..~?t'.= 3I
;+~3GC:if?~,c$.it3::y i;lE l~3i t1=ct Ci ~Iaiit;li~`~, ~~',~. ~:Jl"zi?t; .
II. 23.ddE3i[s ., t1w, mat<3ii3l~, methods, and t`xxii"Iplt:4 are illustrative i}ni,-. and not >n$e-nawC? Io lx. ?ffilsfing. Other f~ntubt:s :und t~l~~G~~~LC~gc.s (af Llte ty.~sclc~s:~~~, i ~ }} , e; ~
advantages ~. S.. )~~E~'~,t:a. xE. ftG. ~ a n t"h\:
~ \
following d~:-;.w ...~d description, andftc~~i-~i Ãtle claims.

1~ ~SCRIVI]ON (W D:1~~~VV~NG'S
W: aA :s a pn;specf.ivu view of a. stei-it..

1. IG. :'~ 1,37' .4 a i,mv.'i-sot:=uw` of a woffl of tffiu stent {ta.k4'"AaA'{3w]4; {-V ft=![~.s. =( . .. . along La3.~. `.i: ~ i t k..A.

{
3 IG 2 .w a flow Ou"14 of w'` i'.:.Ob[)d1m?4=1`ltofa `<iethC>ia o~:~:tL.=G
GI'T..=Is r L<~ s of '?"En, , FI(a. ;?A i`c`, a in i?4ti-sc(:li<3.i1 of i:t. wall of the kei-;.zZ of 3'ICK I
A, taken El{.?:`}g thC. S:T:+.:~
0..AI'Al.

C
F"(~.. .~.to ;3 i3. MzZ>} ~~ Ã i1:C.'sl't ofa wall of t1eLtel'1t of FICi IAõ
:akti1'a cx3.3'n~~ thL:= izi.:e:1 AIyAl.

. IG 4 is a flow z.;>ail of aI??3.Uz' embodiment t`.~'E a mtÃ.i10d :`f:iwhwd ve;:4. i:t?at,ng;
the mw1?~:

.. DE"IAILE #3 .~~SCRI P'Y1O.N

Ra~ri:rilv~g to FIG. `.'A, ;4c37l 10 hÃ3v=73g a body of il'ik{'Icon-n`::cted-ba..za.ls z,? and I I I?):'.t3;fa.i1Ã; an cpongt3;eLa w b1,~~~r sta aC:.tu.I'w. ?;a .ntio'4'.='.i3.. ~L ~S a F'7:i tF. to .`. ) :G, x B, i~_i~G:
LdC?.`;:.. SG.cilo.i3 i.`.f tta'#r: bC3l.iv of \t"t-;iIt 10 shows tlial the stent has c... ÃnF`.L=# `s..#?e.#:L=i:= z3.3.<
il: way. J.,.i::?ce 1.4 <ii#d an outer i3bl13tnTn<3l :~ufiacG 15. 1 ,~37L=
si.3r~:~4~,.` ' :s. 14 s:.. ~~E ~~ ., F:=`~ ~`
surfaces 3 "?s a coating 16 cf.f :.auaiU0:111 cixÃG.e (-x) e.gn, tAtailÃut31 alÃCkxlde i TiQ.,;
C:FO.tin,; 16 ~iw I #InIn tal s'Ja:F'l'..is..E' 13 and 1Idi: wall :~#.sF~~IGL: 14 fÃ.E.Ik3.e' .nL:ui:`,,.:i bà )1.3,.lC.c?.3.. : I:. Coi3ffi-1g E Cf3 Et3R abÃuF..#: _:`.i33 t?1..3rfi(ct 15 furthve ll2oTudb.':'+ b.Lo `ilt`ra+:.=i wios 18.

te: : 10 S.%1`iE bo pri?d ut;i d in a VaÃ'Firty of Y a i's. FL;" ex iImp le iol'um 3? i 3FIG'. 21, a . :31e~.~,.itt; 2~? f. J,~.i.st~:.ici~lg StL'7tt 10 ~~ ti~ 5elect.t~'e3~' uC3eft4=Ci 3~IT cÃcE4:ÃS s~escn ~Z~~;i~.. ~~~~:8?~ ~.t,;.ti 21). s.[il:~ ~ w,~n~~.r,:~ " ~ :s t4at,~~ l5d:sfhÃÃ:f~i ` ~,ir r~ are 4s.3.~.G=.: < o .r~ ?=iA ~~;:. `~#r p 2`;~
generated (step ~~~ E:,~~r? ~.:,f.
., a. 4,~,,.3~. ~}~i,Ãi '~I`_iR~('=
~.; ~ , g e; K :~i~ 3 p~~. i = cA ' v 4 K supi}r~~ =~ '.~r~~~.~~~~' ~ v . ~ ~I;~.: ~ Ãk~~~: , ~. ~~~~c:,.~13~~:,RI, in +.'.:ra ,3Ãm~ 16. Steiit 10 iS then bC. exposed U.S conditions "nÃ
~ic:~.'~3A :a? Ãs aE..sLt~'Ã.i<
~ ~~ ~ ~r! ~ '' ~7 ~ ~ to t1 ~e t ~a {- ~~, ~ '~ ! ~ ~ i 31~, , in ~'=' ~ Z .
:,y <s Z ~ t~. ~ ~
~. , i a aa~ la~_. tC. ,. + cUI~i4= .E~ 'i~~Ã~~. }l~ ~.z~ (step ~ C 3 . ~r~~v .'~ ~~4Ã ~: a ~ # . a t+o1 :NF

~CÃ ~=3 4>Ã'iit~Ã ~~=a`aL i6r a couple of days 3r by;:: process called `wetxrubb ilg ,sC.+ Kxim.i +oxi ~` rf t .. , >ti.. h 3C @ '~ SdySt~)~ 3 z a., ~l.t:~.~r4';si .3--~^ - , i23. L~I]Il.~l ~3. :~w*7"3~;J~,3bi)ph.lic z3`c3,.i: is i..i:.-:i:.d to a 1i?rdlroiSho;.?Ã: st.ii'#.<1Ã:E. by removal of the, aur~:c'.ts.e hydroxyl ?;,oup:~:

Yi Ii Et~:L allz a~t v4 of vtS I~~. ~Z ~~ are ti3`Ãi o3~~(~s~: t~? E:C>Ia .a.t .f~nC SiÃff::<.ÃL y3.~ r:~~ <..i~ i?

coating 16 L~ft`liLi selL=1:ted- SÃiraL+w'.s to b4c+~.~mehydrophÃ.l.t:=z e.g., s}.Ã.lnAhZ~dà op.Ã1l:c ; @rK:p 1'7 24i~,: '{ t >.~a .
,~~ . `?4 ~:x~ZC~i:ÃtÃ'i.. .i? l3r~.3~'~. For Gx~~37.~~,lG? :KC.is:'~'#I,4 ".~~ Ãar ..~_-, 3 , . 3A, :1.~`~z'#:C.=C% of K
lf m,1.~~~~t :~t"3~t. at.j can be pIa~:et~ ~.Gt~~;.t~tl~ ~~~ the k~.~~.;~~.~
~~ side ~a:~ stent ~ ~ .;.~ ~r~~~~~~~G~
.,.t }~ t~..~ 3~r '1. Light ~a~3~li',,5. .~~: $::~L'C:. S~'. ~ ~~'~x st; i 7~~Ã.~i1Z>.Ã~it.~..~S ~:.Il`Ili3l~~l s..II and ; < je '~ t~ll õ s:;;Fi ca G~t:. 33 .~.t;Ã..:`Ã:`~KF
~
coC sà ni~`:,.,3, ~.~.`Suci$ 1'..FL:7in# 1%Ã.ti4`}`3l will ~wÃ.~,Sw [l)crt1.::~ a~~ ~f) ?L i=liSFl~ ~à ~S~ by uÃf3 W:.?.Klo l,,`,,ht sot3,.ce 30 1ll:.12%"J.illtltf",:>>E.r.ri-kcs- 13 and 14, z.1:3luf.nia?A surface >:.` ibea:'ln'.4 2NI w i><xyiilfi.: 116 Ãh :Ai)i.:<i.i~ frcm ctpt?titaF't;, i{<4s wdth~ a '{.umEil't.l. hF:.:; {:ftt;x si:(ffi4#.ent i.~lwnÃ.~.~iatAony tf.ÃS.- i f.'suYt,ÃÃg sLent 10 EfSõ"`i;'r:% f`,o'c~~in; 16 t:a(Ã.t :-sup~.'ehi4'L3Ãtjphil,4 oii lunainaf suÃ'faio: 13 e:"tÃ:d..à ,~,Ãdo ws,3ls : 3.t1 ~r`~,1ce 14, ma..~ h3rdl'[)pl-tobl.f.: oI:1 i~aiEf.mhaal SÃartcÃcS 3.5, in zà wiha.=,. crabodÃ.mt:`n 3ri, flli7ti+i'aE-'d in FIG, 3B, a source of ult.c~i%i~oÃe ;.ig'i;.f..30 C:m bv placed gi:I'wrci:lS` otl b_Ãblilm:S1aa ti`'id^K,.' Ã}3 4fi^c.nt 10.
Li."~!)JA so.ai:.L. 130 1fllv"nnFn:,~t+u.s. tlx 2 5 ahlum3'i3 m that be<iÃ's co:Ãfit>g 1.6 i)f`] a,O,. h;~-,'ht source 30 fflt:K.;?2incttÃ;4 .> acf 1 ~7, swfai=es a? and 14 are ~.~l~okLd. Thwi, ~~ftcr 5utf;cienr il_wÃ,;nawiÃm; th-vo :'e"ultIT3t Ml.nt ~0 bears Z'.=S3`f.ltlng.i6 that Ã.5 hyS.S~~opi:.$3W4.=k53.i atii,w$-m.n.s`1urfiacc' I?wnd Fiydr<.phL>bÃZi :fÃt luminal s13.~"i.,ke.Ãc[.:
13 ai?.ci SÃdC.' tisl:t'Ã"aad,'e 14.

BC3ih, :3Ãe+.-:F;.po.5Ã:1:Ã"~.', 1.:E.f,trz4v1t?x~t 1a~Oit cxpi-5'zslaiC, and wCGt--mbbinG,',.-~ G==.ÃÃ? lbe ;3Ã.? C_.s# iwta out on a tii.:l[;ctivi ;:?23.cÃ"i:~~scalLe vastly eXpax d'1t1y ¾9'#.e &tYrre of h~f~""o~;?~.3:Ã~.l~. cFi?:~~
hydmphob'Ã.c aC.g`L'fm~ L4a;:`.At(.= Ã7~ 10 that c[Ãta bC I'ealyzf'd: Ot::e5' paki.teFiÃs, e.'.#. addition xm: thC:

;~

Z~~```5,.;==~s.F.41 ~tt;,3 "`= i:t~'~ ~'~t'. I'<.=c:?.FF~k:.~s. For ~.:~.i~i~ynki '., ,..ne:~ i~`. ~?~`~~}~i~~:; ~~SF~.~il.t : % . .Ã:
ones ` > ~a~; Ã`a~`,L?v^r a f ~' ''u.rf'~~:.

13 and abluiF3.i#a'ri) :St.#:i fi3.C:i' 1. `` i'-mn bQ tE:i.'!'ned hyd.o~liffiQ , t:.eo$:i s t. l:g}tt :`:i:?C3"-~"lirf3. .111 ailc3thi:s Ã:rfl'r pZ?a'i1o7iS of coating 16 of any of xbi;: surfaces i 3), 14 ,.#.1d/t).; 1:5 mm'y `1~..
~"` ~.Fi:rI~.L~.~ .i>v~GFik.~3i'~>l.i~.~. The possible patterns are ~n#.dtn`:#~..'sF.ti.>
; ? `s.lYShi <, t,fi>.'zli#` E:d:r FIG, 2. std:'Inà 10 beui'F3~T.
i:'~i52.#Ã3;{i16 I~ . is ;; ,,, 5#ydF':;ph]lxc a::i6, hyi,1.?3phi?bic is then c<.'s3ted, c:g, 11hy dF`E3Z:oi3t! a?gr Mz,? as41st.i`a Ff;i #Fw;, > v ~.`lec:m5tctÃo ~*n'~y"#zn.l;. dectroCpints~a'~g, or ri3ll-Ã,t.7afing I.F`
&;nit'Qd s.IbStane.`s ci:.3Fn1p.1;#.blw ~-i? z#. +`.ieSim, b1on-i';lt =i;ulÃ,s 17 and 18 (stel) ..~~..:?). For L=.xcnmpi:, sÃt z:nà 1.0 :'ml be .,o.itLC#, L Ã;.;

S
f.:i~#~1$;t3 in a .#c ;ix"~'3{3~3F~a :>i.?l~F-~.3'iiF: containing fF=
bIi).inl>t'GL uq !r q e.g., pJaidF .eui. ,.F y ky:.i.'=ii.'C. (F.'::~.Y
" t up to it3{e by ~=v'i:igl1t E?r paÃs'~it.3?.el) amd optionally a pol ym`~.`'=; `+..'.~"'.-,.++ ay~5:4#,."F~: i~

Ãt`':~f7n=-:I ,inmi,'1%Ãe#.`F 8uI."vi4:L=s bearing 1:uCil`12pbFC L`=i3Qiti#n, t 16.
I'l3.+w ti`LC.iIt c::fn i?C: d,.io.a w'.d 3.h, process > e3S.t:.:+..{'a, building layers #.,pt]n the ?:ib`dÃ'+?pAi<?bIc _ wn at:cs. In wno:ho I'z;.?oC~z:+llÃ..~e1.- ~
w . ~'=
sÃa.nL 10 Ca.:i E3u 1.1r,hm` cf1Ãi=EL'.il. `.g., d:ti?,i?ud U3 a pi?hai s'olidtiw. z.,Un'._iA FIF:Ig sF#.Jd2':' b.<ZJn'.'to lmu i.Ã:y % ...~pa#".'f.<3. p}':I a#.' solution Vx.i;:I adhere to fla<.#.i`#.`.,#lzit =i.`'+su...Ã'.ai<e..r ..n'=:lI'#=:'rlg )s?>/ i \#y?e~~#T(4 = rC t ~i+; }. . Ii'( ) = { ,¾ pf {~F.:*,.3t211.n)[ c>,-ayts q f<}f~~LiiiAntrL1aa(~L., 1Ã~.i3~{. a}~)$ } {i can Y ~l1~ t.rZL~LL/t7 tt{
,::
i tb . 3 \:1~LZ.a~i~.. ~t.=:. t.2(lLr ~ ..4 ~ 'Y t~\

3,.pc:.?at`a3 g m1>, ci:iJ>,: iLE: spr y"i7{!, i~.~4~:tF:'t?;~0:' s~?#.c'#:Y$'S.3e~Lxits5~?.ist~n,gj or roll i i#i1:;.(~?dõ, _ t. ~-= .=

n.3i a soh.nFi?n that .ini;lue.a#.::i a comb..n'<Ftno#1 of both pt3~;;, sFT.t?
:lo.i lxlrclF s,?';'vtõ3.~ A-vEEh n'uspÃ:cÃii..li dissolved blo?:i'#.ii;i<t,'-uh,s ain`id, optif3i'Ãa.~1y, p:?%i7t':.ets. In this ui#.bt?d.i meF':l, the t~ z ~ li~. . i'~.~, cxz~#.:S ;Ã n 5' :; ~
211; ~-. `~ t~z SE 1.~'i:l. =i ` ,:: t:? the 4 >~.. :~ 3~. i:,;lc. .~. ~4'~5 {:1~~~.11 of ~l~.i ~L ~~a, ~t~ ~~'i= :"~ii..
:p;3ia:>
_ _ ~
solvent ~Tii.[A adhere to ~Ã~n0.~1;=~.r~3~3~~t~bzc= r~.~,~}~i:'~;~ i~~ ~ter-t h 0. The .,e4i-F2~itig '"C,F; 10 wi ,, hs.a es3.#n..,aces sLlec3:Fv l-y a.L}ated, with multiple bÃ47mL`+>trccdt'=s.

s, in ~?in.~ C=i'#:n:~t3~~.tr:i+.....t, :~~.t;~n1~ 10 :s~~utn"b ~==e~F~3e;FtL:
1.6 t~f ~3~`C~t`+~~~~n.~:3t Ti,;f_), '.~.+:`:.t: 10 Thus, is _ ,cft szf '~ `~ ~ r '~ ~ ~ ` } tais.d} ~. $i-k1' ~ ~ coating ~ Y :t~3 tt?
b:ct,e .2`e ~74'~:~.;)~}zt?~: Z e ~ { e\ -iCG. ;`tE+:.xr t~ .i;: Ã.. f~a:~
.¾:t;' a ,.2$in~: SF.I~'.l...;

.'5 luminal SuFfat:.'. 13 .xnd s3d't; wall surface 14 mi MÃ.:1 UV ffi'"1t source 310, tui'i i.u~; ,.r.c.:a: s.~E'Ft'~I ~nv~n,;itpl-affic. s3fi ~ lutt7i#ni3l "~mt fiico 13 and side w az~ sui fÃ#cw 14 bL= ii sn,g;
in~~dw,ph3lic ccse>.Ãir:.; t6 are coated with polar soIF.itiimny .it:ki b.oian<?1ccud cs, g.. ::;-s pf~rm.
'T.F.:'. :nbl>i3'3I.3#::n:A wflil ;iurx`s.iC:~ 15 be.3fieif.:h~~di'i.3phÃ3bIc i:a}f-#tinM 16, on a7w i_t`ht+., hanl.a, 'F;*

Lr\?ft^'!`:.d wi&~nCrn poEa3, soiilt'e.+oniliLi.dt& ulomol'4'udles.
~w~..?..y'.., paclitaxel, g.; i=iavIfta:\\+S .4Fn{..:

30 bii?dtsi' Poly.~`i:;r, O.g., SIBS. 3T1 i.)I .+e s.',inbi)dill"FZ:F'1$.:`>be.Ãsà Iz;ii1`F b0~ coated w#.`:'h. ~.^ ~-z{sltdnt~?#.^:

t1l<3f ;.ilca3.}t,a.s ~l cti?It"1b#.t;ilfFt>Ã: of boldn polar t.Iid non-polar s%,?svimfs with ?'~sipech`w cly iÃnia, t>p? ik?ns..~lyy p(?lymC;Ã`:`*., In ,.,.iwffiti;a' C '.ll3bodÃ;:lÃe:'It, slt,`T#t 10 bears co~~ti}3ÃF 16 of rÃ
t~l'i'f3:~`.~t,.~ ~It~~=;> `>e Ã?: 10 :5 .24ft ).ithie dark }t}} a Zim?..:st-kiil'VLe3.1.t for f.S to be4oln:k..m.hy7.tS\F\lhobic. Next, 5 C 71rii i~ i ~.~:;^ 3: ' {=:='c . I~?: "
; ÃfÃ~Ãw; 16 is illuminated with ~ ' 1` l1 i :~ v't c . . .. .
~C?dsÃ4e 30, :~~ 'i$sZ~ it ;ii3p<;Ã'.hvC.Ã"??ph3.z:. LunndFx`rfl sts;'taS:t i"Z and 51ÃiQ wall sLFÃ'.,;:tc.4 14b:'.kÃt :tg ca3af.11.:g 16 .ÃB't?
Cox=.ted wi?.q ;.c>a> n0lar solut ons and b:oniz~~~culzas. `I'~~~ ~~~~unnir~al sUxfil.,c 15 ;"- coated W.lh. pZ)la.'2 si;.,uaon,4. cm~ biornoFe<-ules. .Fn otie 's:mbodiment, sf\',im 10 can be 4t:tat~.'4(]w>fli a ."'olutLon il..L3L ina.wud:s a ~~f boih, po1t2ri:~ii43 no;cl"pGe.:~r `oi.=eii'iavs, witai..

o~'s r".:spU%:~t~~+ Z' ~7gtit>i~'L; drugs w7d, tlpf:ion:~It'W, p)lL'il`}er:~,.

As iEwu',,>Lvd caqkr v }ni:lni.=fxkeÃ' k::}nboa}i}.C::nf, rathr'r than illuminating fhe umii'C%
.tumt7al s.ut f<3Ov;. 13 aud -.3\}Ã w%3ll s.I.tft}ce 14 bearing coating 16 or \h;. c~~-0:i?e ..:3?tAt'}?tnal su;f:~~~~ 1,55 (in step 24 of 1-1G. `?), selected regions c}i' any ci 'I 3u1-i~ t~~, 14 z.~~: ',i: l 5 ~:..~ E uze3);

be 111un1. ?sitE_d.. and selected ri,:gÃoÃi;i lnav bc coated ÃT. E}e3i.t'Ld polar and non-polar 15 si3.i.Ã:1:3n:5. Z.ny nuÃ}ib>.. and viÃÃ'.Ãil'f'L)fi of coating pÃlIieE51S
is p0ssÃb:t'.

Re.Ã'}`>z$tA; ft3 ~~I~7. ~= ~::"}C3.~,e.'~'t~it;f~:~,t3~ of yFt,`t~C~f'Y~3$i~3~; a selectively coated stG~`Ã~i sa: z~
>T.a 10 is generated (:~f~..''~~+ 41). Si~.~f...C.C:~s 13, ~:^~ .-.:}ci ~ a ) of sl'!^}.n: 10 are ~~t,>awo:

L?>.tf1 xlYi,O, (A`7a.p 42)y \.,f.$,.f>3'y'trZ3ph'.lic e.gsup.ihy4EropAI.1i.Ãs #0~
x.ti r . ~ 4: i y then =
%~ L''^s''~l~~xi'~^i,:~lt.t:=
~,:~~},. ~.~lflTc'Cr ~ ~..3 ki?'tÃt3ka-FiY ,, si?. :].:~T%~ 10 fi 'f~e%=?<<~E.;,i.~,: tc t:t?i'.tdI:it3nS

Ei Si;.ff,ci.ei3t .3 i:.i3.Ã-sa:' f.hs.. Trt,O 'oc;'i.Ãa:.; 16 fL?
'=~,IJIi, .~~3.y i~F'i3~~}1C3~`a%~ (step 4.`) ~34 I;tF
h a..
rc.tt a r ~~ x~i>i'kir~::Ã~E i~i?i a fe ~s ~~ ~ 5 tiÃ..
~.t"f >. :~.,ta~: ~:i~~^:x<:L~u` ~.~r ~~r5: ~~1~"~:.+;:~~~ 13, 14 ~,t~~~, i::
15 tz' s::jG.L'tI~d portions +>f s..ial.oEt'ts 13, 14 anÃS 15 C3;: .3f.'=i3~ 10 bt.ui"lkxocoating 16 are then t :xp5}sZ:Ci `tz'3 ~uffi6':it :o celk,zse the coating 16 fo bi,'.'i:f}3>iL. Iz`Ji;.:'op1h1':iL
Q.g,s e,- , b,~ ~IV i;lunnination (s:>g: Xf' 1:~np. ..,s0 m:.r"qt,.s exposu:=e tirT:O".) 25 i.~'.p 44I ;joiL.``Lki'`P.`d 4'L1.iface:: e'^pl);st'=d to UV
illv=,ini'ii:iCJn can }ri+~.'fuds..' fh>-w? {,..n`.lf':o surfaces 14 1zid z~ boarmig coating 16: Si,.aeL'ttiaCi Sfidaw.C;s Iffl.,Ãi! have :3ei:n`v`i:p:;~ #Zo'`

::i u7i`3:I3.:..i{.~ are s~1i7:~~{i~~` exposed to conditions :~~I~lc.3eÃ1f t<'3 cause J.~`, to become h L~.~,-z1~+~It;b,~. " :~`t~:~3 ^f;?), rI ~'3~'~ conditions GF~'<s i"ltl.~ t _ " ~~.e<:~^i`~.I`'r~

5uI iac+:1 (' ..F.. luT.xwli3_:.l and rLbriÃ2n1n+~`~'l Su$'at34i"Pv, or any other vo.f}.3b:natÃSn of s..3..:.}.cvSt with t i~Ss.`.~' ~ 3lh eC. a it~=~l or a ~?a3: f#tit'= tEe, esF ?`, i sz i=Ã... = t`
;, I~~ `: 'S `ut..
~ paper ~ .., ~~~ ~.i c'. cr. z~i~<I:F ~r 7t. ,:

1 ~J' :i'L#.iib:.i?iv, and .>iQ$~:.~' exposure can be dC)T::: on a 8dGc:t.1v.
I?1z4tt3 `G~i~~ %ulli, expanding i.ht, reL`a;ic y?b-pdFal4F:`: i(yflhVdr\1'pin(1~'L.~3C: ailta hydS'l2phalic regions that ca3F be ieal c.~';c-d .< `
..x,"r`:`x referring ~'g to FIG. ~=k , s.~G~?'~Ã1.~.~ is SwY?<? f:t,! g.. . ~ :3~= ' ..:4~i .,_ . ~, t~i~)G:k#c3t F?V~,, F ~i34 <1:isF5.
spr;tai`.iF', ..lL=d.ost:l.fi.'' tip3rlvi3w, clei;.:7'ospF.i)I}.iiag oi rE;i.i. 4~O'r3t.ti'1g, in dewirct> >,'i.'2. :...wnMo{s) (step '=;;i OF'xe interesting FppaIcaboll of wL'`[-1`1.3bb7.1..-',' ..:s that it allows just t?vS:b:fitLce ti', i)~. Wmiv',$.E frona a k)tVd~t~pz%ifit. poro'.-+~..,~' Ti;yO' t.::.faÃ.ing in.w a hydri,pboF.3ii suF'f'iC:e, w3;;:3fi:
leaz :ng .:ri4.d. ~us)d\r,ynngj ~~roF.~s st:~.FcÃ:r~? ~A~rcxro-~~.~lic. .
lbi,~ ; an enable coating s;.~.~?. 1Ã~ S :i:~: ~<i~:FC?;.~~ ~.~~.)i~.~si~~FaÃit~~~s o a ~~ a r ~.~.t~
~~t~~~- ;~ o l<~a ~o I .~c r~t s ~~_¾t .~:~~.t d1 sSCrzv4x" SA;3zp ~F?i~'i)2 pony#i?ei'~ te. create S [rtF`F 34tiÃ?g ot`at#.ta\ C t #~~g~~?:~iE~(;~t? To `,f: coated, ": ~ ?;..oI~] inside of `~;.c ;3R#i~3L3s'f',~~,: t(?cF[Fl~f. .~f? one ci2ib~3C~f? . 4toI3i ~?+ can .r~}i 1 p c ~ 'c fK ~r { .
ti~,9f <~ ` <A is:.s~t 3titl~'L:{ ,~\^ ~~+ 'Sf.,~'.n +~~3 Yy ~=ilVuLv~AL~16 c{
p~. spraying, '~.?waLV,. i~Ã~a Q#iilà lf,;'. in 4.;f3F3rpC3li13' sE,l~'.:Itton. 4>()nÃ.$1;1ing bIttli:l6:1lc+vL+les, i'..hs.., paclAi#.x4 i c };., paC....[a?=iei zi;Fd bii?doi p'i.?>ymer. L..g:, S IBS, and a P(#9:FÃ" Sf?;L1ti~~i;.I?
cs#3'tt&Fi :tcIg b.F?.,F;:?kxuloj, y g hopM=~~i:-1s e i..~',,.. 33eparin :xs.Fadpti.'fpncl. In anok.,Lmreii?{)l}di mf:=nÃ.y sÃCiiwtE 0 4m bt,, \.':)aLoU.. f:.`y.,, ...
C
"=t? ~i`~, t51~3i:~3r f:i 4;; ~;~J-~~4;;):~'~.~:<~ kz~,1:~.~'1# ;~.
~:~~:~~~~Vt.dF$IC ~~TT'sl~`<:lt~. ~.~L`=L:~E'3~"~,)~~F3:i"F~.2 .~i" i'E?~A^
F.'oiÃ?:':g, 321 a solution flli`~: includes a +.,'{3i:#1b:37.e~tii;lx of both polc3F'a:3E3 #.lofa-;!Folc3, solvents bZ ,F ILspÃ,o_lv:.lk dmsol:?E:d b1E>m<?le%:uluS; c&, drugs, and, ;?p1ioIFÃffly,, polymers.

LiA ano ther 't.=13~~~od5mc=idÃ, once stent 10 h'ai.)l+LWt3 1t41{.4ted vv Att:, desired Mo.;S.) o.k`/cL1tes -,-AÃed. hi his embodiment, <3:tI&%37 jptx? y,::L 's, a fiC t',E:3i'lzl Pf5:'L3z.iS cE,i3'i#,3;Fg i`:f'rIsOv t:FT'2 be q p~

2 ,T%0. Q>bF be applied without the use of higla~tem~orature step, TÃ.~, c.:t) be ap,.?~I~c>; ~ .~..
~'i.~ Fi):~=~~~4TV.F:E~ ;1SFStCdl deposition. IP this cÃ"Pibociai-ni;t?i=
b;i_?mCilcisi..e.. on .he5`tm Y .:=..cy.x pac:itaxol, can through the pores of the second 'l'~,O, tayer.
In <iÃzot'he; embodiment, ?Fvdrc)phihi~ biun?C#[ectF.es :.4tti be pack<3,>;;,>;: into ~3\ d3Z`,phiJb3i lipid capsules (e.g., liaÃ~~soiFHe3) md alpplFvd to ai~ydI'l;phii 3li ~ i1~zF.lf~ 16, 25 14'urÃhv? a~.`fL'"nin.:. ':C? F:C'i, 4, ,ÃÃ'j' 421 of Fi:e}?t?~ 40 cFt' .nw;.udo cC`Flti-in#

n ~ FZ?Flti s'o ]i 10 4'V :Sh T F,~_+~v that i s tIi'e:'^.o pol"oviS= F:`.g..
mvsC. pori}Lit or i=a?Ic7'4e-p:?aoL#. K;:;E'Ad oÃ...eF s'ti:=,.Z.cted rE;=gFon's, with TFp,Oc: that is FfeF?'.jrail S.ITaol~th, .F w=.,. not acFaio"poims. IÃ; one <:# FNAi'm' :K the m#~'.)i,ils coi$FVi: with i:2a.1,d1 ~.?o a'<)ll.a 'r`,s3atini., `a. ..`aFi bC? :F3F?.i."Fal .2 :C_. :-6Eic w;ili aS 5 i iax?ta `~ ` 14, ~ r x~~{fL t~.?f:' ' ~ k 2`a~)`5~`^ ra.iu.': wall ~ . ;
rv~..x,..~lr~"' ~'x,`i~'a~}. YJ`~n: F3a)i)t~F UC)cF~a~ ~~ .,f ~ can t31.=
l.n..n.icll3 swd.a'F..o<

i;31offiea' t?.il`aE?(SdiF?3=4''=nf, tliC` r+`. ,g14~`:i3::i LS'#fh fFixilo--poIC3:+:x coating can b:: a-b`LF:Ia,IÃ, "d _,?.iÃ,iÃC^ w :i+.arfiaces 1vvllflo mo 1f.t'[ri<rt)s ..s,>l_tl7 S%Tlof? .h ci3:F.Ã1r1.f, can be l::.tõn.n.t3 and ?3t~~ wall ;~ ' 13 and 14, .._~.'~tÃaE.`= sicia:. 10 coated with I1.:3I1E`.+-~~.~o.t:i3..s wf`..Es tixnE~E?\h 'T1,40, uaFx .ailE'a:> be , wxpE, \ ...M~ E, i lE., Li3;.rdFt'ÃÃ7ns ~ K tbr aE}<Ãt3iIÃ? a't t.F'a~. ~::..
~, Ã:~~.o.tG'~lf: ~t,. ~ ~ ~E.1 ~t;=~~tÃ,. ~E~-~~~E`~~~=L.-,.tf*rt~;a;<, by UV
irradiation ;keL 44)~ EIsilr. 4 .'oiii 10 E:i1:F3 Ehe1.. be ;x~.`tose$. to GE`,FlvlitÃ.EfaL s.]tfflicio,:3t to cause s0lco"':i:,: T\,:.=_t'.."ions of ci3at1#.Ãg 16 to b cE?me bv''drl`phi}bi:L,, C` g- b3 p>`.i.'x4 ~ g sE`# ia E ,"r Fa3 E.i.~.u'k ~ csÃId 1`':it?i3S a;`.- a +:'E:I-taFiFs ~Itlli;frzFme , s:,g.r c? F1tFi`IIb Gi' 3Zf days C:f Le Lt:.ks Ãtili:p, 4 45,. ~~YJ) s tl~p 4~
OtL fo ;~lt. ~:n::~c~,.`ti'fi with I'?:~:1.Ã~i2 ~3isÃ't3~2s+~'i,~~y. will #4~~..E.`.. $.#"t:F, Ar~r~. aP{F. ~. L.; a s<.~. 95(2 1),5~~t~ ; ~~~~.2L,~~'Y~f. STF'rh:E= s Ã~yÃ
aI E~i~s i,iZ *ltLtf ~ ~ttli , cr i I~E` the ~~21Fi#~~~x`~~~~~..=C'f~i bo4+Znne i..y`a;+.3pnE`>bic. ~~liL re-ti#..lti1.~~ stent 10 can be coated e.g., by #.ipa.:(i~tin+.:, giÃ: R

ia:k'.1,g'.s ied 4p.s3.Ffa .o sp3 hy3t3.e". ClE'.S tTE?4PInFziix3 g iFr:E)dl^E:S?` kF :ti., h. t.L:4i.F'# d sC3lÃ,i.lE?~"s LcmE>.3.Fning a +..i:mbÃA7's~iSun of polar G#.F1d c.m-lu'alfÃ:Ãg ~\~34'.~. 4 f ~ 1 ZÃ~;.F'i.~E)1 4?'x =~ ]s 'Ji:~.(a?E)F~ ! 7\'l.~ l; t L:E>.~~vti;y ~r~..f4.' :~}i..~l~;~~i~=`T~.~, as 'Es.4sf=r~'~~L: crti?i~[:, 3 use, stent I() i3:3. be ~.~.f:7eS,. C &. dt,l 'veF'Cd, t:f.siF y. a swad:etC'r it`h-v~..'Ã~ sy:iEean.
Catha=:i.r u'4siem u a1e d0'suIb3i.EI, c.~., i i7 Wang i. .S. Pc._.,t NcZ. 5 ,195.969, 1-1 a.F2`?hF1 ~ U.S. Patent No, 4""~0.{)i?6, miEa Rae&T-D'E :'f9E1:s U.S. :j .isf,:l.f NC;.
6,7 ~Efi., s12r S:+.:Ftt, and +T`~~~ . t \ {~,_`~~ks ~vv~'~.~' ' f~] i. S:~.L, +Y'~`.=' ' 1~~r k+~+> ~~ t?i ~ }' a~~ t~~.= ' ~' } ~R or i }p-}bi o t""' s~ ``r^~Ct~'Ye:a`l ~1 v \2 r~ 4 }
~~~' ~.aZ}1S: .-r\
. l.~.i4e~~ l ~ the ~i~~~~.i.~ ~.3. ~'}~i.. ~.~3\. V .

Boston SC.F+..l.?.?i,+>= .3c:Ã{ 1S,.E>, Map3.eGÃZ.ve...N'3.N . Stent ;.i, k`,fl'i:2Ãing naor\ :3.``s.in one type E?i`i~
'LlÃomolEcEa.c, Z cY ,bim11Ef:FoC.uloti 17 and 18 df,:hvS. .F .~,i,' a7F
3TaIkÃie"6=u.ii.'.:i tt` i,g., e3 bi t;E:
a ~=
~' : SCr'a BÃt.Y:n`v.. "`~v cu. l`:~t 5 7 &nia i 18 E;isx3 ti'~r~.+xLõ~~
t'iE,F-" E3s S:=el~.J of ~.~,.i C.' blood )E.=sy ~ ~v . . . . . . ~.
C, v { g ~.=v~~.i Y~
:%.ad#~~.~#.L:z~...3:t ~;x,`:i 3~~.'ioE~:3.i .x1Ã.~st%ie t~L=ls:h.

As U`scussC'd. coating 14,`t of qzvnt 1. 0 ei3an Int;lt:dz<T 3,O,,., ImE.fE,:".::Ebay >:tÃIniu::E3.

E3i.F? w;iic. T;.ti->;l;lÃF:.: dioxide, also ki>owÃ3 am fitE3nf.Ã.Ã::23. ~IVj E?xido or t>tama I;C the Ã:at`:a.F<3.lE:y EfcE;i.3rfià #? E+xiiao of tItE1ni :$32, s~l1~~I~33~.:1l f1~1ul~à Ti~~=.=. ~
33\.>v..,F:', ~ ÃI~. a lEAtl'i.l ; a- r:.z ,.~ f f\~F~F~..ti ~t Z . Ã w I ~ ~~I~ i .~;
zLi~Fli'., i1F7c :,b ~i31'ESi.~~i:FtU;. tzixiF3aÃÃ.Ã~?1 dioxide (B) (~ll(33`iS~: Fl~ii ~, Ã..4F ~FIFI~ ~FE#.ti;S#.~~ ~a3~ and tÃian:uiÃ.. dfiok::dio (H). Cup {'# a:%i,, P3'(3g. Sa.?Id Stxuf.' 1,-J,x.c'n2.
3 . 33- 1.77. 2004.

a:ixuÃ.3n4,, .a:.:, kmmi to bc, bsood ctf,Iipa:Olo. Nza.iÃ''.;.~ a ut., Boston swii'.E1tEfw c<?rpwatÃon izEto.;]s3l report, 2001 Ts-y:gi1FlfSa' C:< GIl:, Su,f;flr..'f?[<i. Te[=f..
200:104 1-4-41L 2i)05. 1-l%oc;d-;>.s37t1E3at.bic s:3; it.3nc%s show E`?:]lY' ÃI7.tIio;:' UldLÃct:o}'t s:if blood &M >i3ÃÃ?#at#i3F2 T>O2 f.t both ~'Ee.IEa ia;1t i1~ 1~s3~E= phÃF?es shows low platelet ililhEh7.E1Ã:.

.+Si top suif.a\e of i-1Ã~Ã~3~i ~~~ilii`+F ~~. . at 1Ã1 fC323 E~ti1 ~3~~t; <3f e's~}E~3.St }EFEF to aF.~?i~s t 5%) +~~L~.,=:_'.<:õ=:.`~~
pd..~1millL;=tadhos%#.Ji tE? TsO? MRFÃi.>tjd'il.:~.

Ms,3~;3}iolf3gS mysial structure and doping <ff'I'i,O, coaaT.Ã>:~: 16 are so:t7w irluui7.on,5 that fiti'.fi.ia to be tcF\4ii :Enti> av'i .omit whe$:t 1T3ak:iIg i1.iid using SÃ.+..'Ã1t 10, . %0, v>?mung 16 of s?ep,; 10 can bea cm Aal (amitas~.~ ~)r i-i.tt~lc cti~u:cÃuÃe). Crv~'Ã-ul s":uc'Wr; ;s pl.o:u.acÃive.

c2 y"Aal 'q2LvT...t\4r4' also has L~14/~.fJ.~..i~3.P or w1.~1<ghF.~
',V 13iLjt.dtAG1.4it4at4~} [y,L*,'twci~?~.2a~.\S s"~'_t}{~4x~:' : of . .. A . , with ~ ~.sÃZT~~`~~3l.'~~[Ã.zi;i I? and 18, that can i~a~ placed on ~.Ã7ri.f':IT,~;
16 411Cx.~.~.` a:3Ã' Ãti a:E~II .'i.i~3~.Ã'~t:?~"Ã b~`t~~.:
pt3 't i-n<:Ã'S .u, &i1E Ã?Ãhe. bii?13.1~yl%oulc~. Ct?al3:i'3.zg 16 cE?f3 also be c3i'?ti'_3"p;loli" ;Na;: ; ppLla."#amv : ~.`al., ~'ta.. ?a?>?à bstt}.4.~~`r 98r 2006;t or be. a tomb11.aboÃ"r, of one or .".3~ort', of -dw phzls1;s: s.3.1F:$'t?ise; ,..3:fle, b.".'i7i'kÃ:Ã:, fS.I#3oI"pho.fs, anC}llochà lc;.; :Ex`.dv::('-:C) I , I
vmf "OÃ' E3Ã ; :FBrn ( v) t.3?iw<

ii: Ildsiead of ;a:ie31g puaCr 1%03 ib f:<3c dr1`?? phf35pl1o.tl.T."3 L.ia bo. eFnbF'Adt.d i'l a iow pi.'=rz.i.'ng...g4 about 0.5 to about ? ./ii ) 1:1iF5 Iil`+' 5l0 =l:tyt':
(0..g" t.Ã.~ÃFhÃ' rr.a3sT]>i:1 mri7a1ez;Ãis:x process) to increase blood ::+:.)11aI3;.1fibI.l]ty of the coating. M`sdtz . t ,a.f.

J.: oth('.r 01.3` .bax_filmvlts., t;<3atlla~ 16 can be a f:f.:nibÃn:i:Ãt?.:
offa,O: and "t?xiL 0:5.); or a, C:om.7:nat.fu111 of TÃ,Or. and O-xÃ(ie (R1:3V
x). .3: a c.:C3mblÃ'?.:F 1o;?

lr:>>x s..e-Ãd : ~~uOx. RuOx and I;O
L can dtinaSE :::iF' pJÃe:l>ÃÃi1 Ez?~~ t.Ãfrl`=
onggoing, in izli cc~~~is, surrounding stL"Itt IL+ iÃa 1h~.' boily, because I17:4c ci5fa3p.runds can J.atalyzc b..L...,kd1own.1~f by"w=~:roducy Cri`stre4:55,.?rii.CC11.`..

:t? ~ l~~ 4: coating 16 ti;c3~i1 ~~,G: doped, e.g., ., ~3 ttil.E~'t~ ` ~TE ;.
Z ,al l3~.xT~1 (C).. nitrogen (N), bi83iAÃ.lth. (B1). S'iln~'.~`d?t7.Ã2 (V) or their coÃ?7bÃIsaf,ali. Fs'. tI o?;.IT.fy t'.3"ah_:ince;;
20 TÃl().: cL?,,`,,vwr-sio;.# i-.~te of phiStE?:ÃS.1L`s.3L,ed hydi'.:+ph l Ciiy' and 3"eCt:.1cG;`e .he ?'a'ts o.tt`d;:.t7F :'e#':Ãi:`n fIZ`m, il-.dÃa?w3:a$..C: to i: j'Ã:sophob:C: Sti3te. Yu t.'i i:I+.., C
~:.~'rrrd it?h}.'s. 9:3: 19i9 ^ F.i:). .~`'.~i~
:?Ã3i /4??` V-doping {aoCir<?a::c ti1C', water oi.lnii:14t angle, wh zlS: Bl-V
(aIFE`:1ng c3.i3. cÃ,.}ÃaF'.'`.d;:<`.=
31..ÃÃt..v'wluÃ.tui: i3f a low i'vÃ:iter con'tslut .:4a"`..(21i u31dcI' dark cC`.I7d:tÃ.oÃ;.s> Hon;` i r i.l- r`t.fcf;:

60. 1296-1305 ~?'0t`r6. C--d43ping bas also becii reported to influctiLaz hydrophilic ptÃspcri;c;
25 oa Y Y<.~.r;i. aa e.` 't Gd/r .T<F}'~f So f?d FiNS 5 10....:, i" -. 2 006.
A~
xÃ..#~t.1~~:~r e~t~, techniques ~Ã~3 ~'Js:, tis~:i3 to deposit .1;~,.~'v t:[.}ut1Ã"k; 16 :k>: 4Ãem 10, in..`.udi,3g ;ol-~.;cl routes and cut~~~~le eiectÃ~~~eposition.
Karupp::hm~~~~~~ ~ le al., .St}he< Ss:z,:.=

.E511-1t3-2v , ~ ~... .y ~i^ .'_.;: ' 'UiA3pLlk~...a '~~ rf. .t'~~7. ~. C#
r.E::~'.. P F ..;Frf ,~., ''~ .,:i ~+ ~ 1 ..',~', r}~'~.~ir~' <"~I:.'~` c t ?+ t'f.

Hi.Itt13r'3 'i r?3'õ z t 1:#;"f''$:d>:.. 11 54>~~ 215, .'t9W NlGtiÃ.?`
df.'pos,Si3.-i tec~~'x: .iqI:ÃFws .a....Ãf:e. a: h:gb-ng step (e.g:7 heating to about 400 C: ~ t#.3 tfsrFl dc'.-pos.a let$ ii}i"#e 1.11t(?

~¾ such a ~ xgh^tL'.'u:p4Ã`iitId.C'o step 1,,~- #.:Ã1t.es2riiblo (S;= g if the :?Eo:~At ai.l'L'ad'y l:_h has a coa{ir,,g of .h<:rincf-sens~~ive ~lennenÃs". 'Sut:h as ce~ta;n po;;
mwwy.

~ysÃ[`.#2'~~ (MEMs), or ~~?i?i7i(?~~ L# Eay~a i7axL?'C72i`:~~ ~= cA..~~SÃC`+1 f,cpoS,t1L3.a i,f +a 3,O=,;s :3n i'se' used. 'Lf g},l G1 t.L , .',ks{t}qt'Tiu:r . ~{ :89 .# 96, 2001, Gfts;`eI MI~~.`hQI

[:'r tr.>Yc~. ~c7.'.~, x~ ~.:l~i: L ~ 2t35.lir4'" , \ ~, .~l.kt~+~,!. F.>r g ~
~)a ~R z"= ,.` , .
, .t.}' iG ..2':vf:~~Aõ~5~: t~.

S ~.~c~~iS:i,.~:i(~ 3, :?.::~#.~,a.s:; ~4r.tF~ii:l#;`+ :1~'`' SYntht::s71:etj directly in s..#;P,,.ns:o3: ~Us13"ig .`. ?`a?:croi't <3i:=
reactor and `a~'~.?.c .3i1Ãtzclw-S (of ,ibowt 70lem t!i diameter) a1'e dqpt)Sttet:3 by a dipc.?w p#>_?i,ar.;is ar;. rZ?wn c z> r=> >=s5;,~3-~~1#,.h~.. a; i.s Z"a+ xf. ~;~~~.E?'l =li::3: r b:~??1 ~~ kd`,~3C? method ~.Ã`~;'~:s~Ãs~~ll .~ another a'~~iv,~?i,:'a :3 at avo#d1..}i4T~.: .-1a ~'.a.::~i`r#.~d.~:t~i~~~ ##~.'.1~~#:~"l~~
E~c~?d?>`a~taS3i1. #~~~l.E)..~=ii;3 4ad...:'i.$}; k.~.3rij 246. 7'~716 2005 . . -~ t o ~ ~ s.., ~ {\ will .:~:a:e(.~ 7 .~~' ~.1h`s::rz ;s ii.\i:~t,t> t2il! bo~=ke. z ~=x=la.i4~-~~lij~i'd TiC'l. {~-, coating ,~
yr?.'~ .t? k e= Y~3Z i ~ ~~
A3~ .

~~ =t. . . ~ r' a c a rt:~~3i:;~=~,: ~~ . in E~~i Yu <_ t<,.i., ~~,:~rÃ?p~?
~.~~.a::3;= f?l c.1# YÃ~i~5 '`~-x~~ >_.,~~,Ãi . '~-ar, .rr:

known f.i> Sw.::.ca: 'f?4om hE'ElvY#pE.i{)bic a4' tiuperbVdri}a:'}inieai\, we1S.'.r#. Qxq?o Jl i.ii EaYÃt".i:#.-vÃf?l::i. (U W) T}lis cf1L:Ct exists not +.?l.13y 1#i $he c#31:~ta~l-n:~ru#;1.o p:1ascs (Y;., c':t i.d.), it fiÃi~r3 Q~~ (7~, ~; i f tE'3`3a# also .>: 4' ; r~ ~'a'. #- #~ (,` 3.~ ~ ;~?l:s at' ~`i,4 fi(? , -"
,?3~ p#Li - :~di<~#aZy c'i c:itk # : .~.. 't~: `Y^'7~ .t,#}~`3). ~~~I,~."ir ckls3 ~~Eii}Ãi?r 3ii3~4'JÃ ?1n~~e, I.`~' li?E~:t, but .~.1~= i~?~#t~tL?E
z~tua3'i:w= effect only i~ii?~i-:~I?t.t:~~2' p3. sti. A s~i3vrk~ ~`d3i3~`i~iii1L s7rfi:t.C; C:tEI, C:L1I1tiLi ~ water w#tbi an :.'.: EE. .! i as ss fla'i3:#.
5". ka `~ .. : fc t1 - .? 'iai1~3-~i41~'C,Li, \ 5~ s~5 ~^v `i~' "v.:~a:3 `~`~~ai. Gi4i~;,.a'~'liE3~~#.##1~: ~%~~~s:wt of ~'~;~.~s e ::=\ ~ ~'r`
~t.=..:~_3~I~:::a.i:~ i;:.(l ~., Ã', nt3iSFt:S .4trE ~;i~:?~ (that ~~a~~x~ pore d~sid..#?'.SC',~teJ's ~''t~~4C;+.~112`t~ and >'~#,~, t`a':~gt+ÃI'~):#?'?sr ia,.#':. to fl;i~:
e.l;.hu-gpd qu3 tt-icL '<k#'ei? ~-Y"u Ã.'l CZl,y J, l;hwt"li'ha.`,'n1.PixFot(_#bto<k-. r4, 148.:3 ?1-39, 2002) ;:IT:Id 20 s`~=i'o ~~(?.C ~ z st?LlcÃ1#rL Thus, exposure of ~'a~yt~'Ã3~~~tC?? r].,C~:
c,.# i~: l.i? ~.SY . ;~Y # ~x;:
_2 sf?a , L'' ; S (ti`.o:õ ~ ?'? nm, `~~?1str.~ii ) will 4'~i'iiS.;ak3 t~af`.
T~"';.cl.Ãf'.~'3 leJ back to st.f~~;$ `#~:%IP`~x~3a11~:4=.

'I .#.C Jo L#..t.4 Z?f UV ~i g 1'1~ 3 0 fo r Ãxl L.m à a.t iikg s t t',n à 10 =?C,ari :f~i. Ty, Cr`,,. >,f,c3.Ãi#'.lg 1. 6 C`.;:?
bG L`'`,..l fibers i'.~,:a;.~pled to high-power diode :e4:i`t'r5. T15, Albf'..i8 can bt., ~IttE.. ii7tn daff #.3sC.:~i':'s fhzat aflli;~v ..at:e~vayc, radlation. W}icii fiborS or pla>~ic rods or5hoGts>
are notchod Iikrt is = from ~ a = the Light o r ~\ ~~ <.~.}.a 25 ~ Ã~. "al~C.CC~c~Z ~ out :#li~. C~~,;3t3s.Ã#.. s1:'lE: C~a. I~"i~.
ITl4~t~`t'1al. Li~,.~.>,- m'c:il by Ii~;; fl.o nozcb depth e=I11e frequC`.i1cy, as ti"i#., di5'.:Ã::i..c~i:s3n;.
td1E'= ;#gi"2t Ww#i...t:i =

Ro a:.L3g .IÃ.F fiber :Ãis.L3e s.t'd<''i?Ã 10 u3i1 provide w:2#ftrri11 fflE.i:.~~:i.Yal:*.t3't?n in t3ll dli ecÃii..#n`.
Inkatt".ad z'.Fr\?Ã.ctl..ll:; tz#e fibc,:, a threaded notch can ~ie r;el.t.#"
`teLa Ã-ht?.. it:x1m#i}. S.\ al3 i}t>U<i.#<?ns i'`e"t:3i?w thL awE;d .o#" rotation. Fibers c%tÃ3~: be t.l:Ati-a-ned fr[tm, c:?. p ayMICIitr 30 (Yi ~kt ~'~_if ~=ti .i i) f.C?1'~). Skl#(.Mt ~#'~?~i?vr:~ ~:'f~:Gt gi.~~'a{a J~J'~,.Ic~a3`kS~;t:satf~t~3: ..}kl4 ~:::# r ~:im {34a e +Zr . ~i..~.`_?#..t Z)0;~~~ip-iii. #-o t.bC?'.3Ã 2rn.m in dIk:ir."x3:-Aer.

Ai S ~...ycLFSwd, pla4lti.s~.vÃ?t 10 #::t#:~.tC:d:~. ~'~ F }a ~'~z'Sif.~Fl"t~~?~'::il i~,<:.tl,,.X.., sE.~~~.:~oI,1i az~:~ ~~3Ãi#.~;:, ~. , `rw,., , w >3up -t'hy~.~rophal.c 'FiQ, in tl-iu t~cuk wiIi. t:FmTi:,z.3, coating M a,z=dr;)p`bfbic, .ix3 h[?vfc? <:L`, i-LfÃ`ÃaPy:?e d>csdI<::?lc to si.os"s (e.z;., in Fi-2c d3:ak. #.ix piE...i~~j:I3 siÃ'.Tit;F cu0.:Led. with I:#?}'d1'E}ph1l1c, c.g. Y =,oy, w,i:ho=~v...

.`~5 tE:Ini31iw i yia;i3A3ih41bÃ.c, Rt'.Y.`%isiF~ iioxi# s3.1p t..z.#ycl.Ã`dFphi~ie FC`hydt3A1}1GÃbx ~~ailbL
v <t:evoni.#~.=~a ¾ ` `.? t' Fw x r # ai~~~~ i? Y`l-ii~5-a C3, e}LFti (ÃIz:'Ã~IR_~.:-'~t) ~r i1 F:E~.t'FI~,~~'.. t,~~ ~" y~~ i.FF;:.

85Q 1 ):50rz.7,.69 2004, IIri o.iae eimbod:Ã-m;;nt,, a ta;S L''Ã" of LrÃ.gaÃ'1Ãt, diCSF.3pf.FdF.d., ~
,.?ak4 l, siliFn@,<ÃrZ'l 3-i-FanC:~

x 1 and'C?iflF.#vt"Ã5dl\~ I --#.a .:t'., ci3n dL .
~?f3s;tc~ < R'ia i f~k ~','i `~A +~Z~..~~' . ,1. \f4iw2 a '~ ! E t~ f ( 4 ~. _~ 7 y ~
~D i.i~.yC._' of ~~~..:3isi...~y'~u7EC1#~v C#:Ã
~?ti.~.~La?.~~,'~='l~~~fd,Y',a'~)}rZ?1T~.FZ: tFf.'Ãd~. over ~,"~.1.
~~Ã`~1:#'3~3~?j..: ia,'t_> = b oF7:i115?
16 can E,nhaii4k. the \ 3pezhvd;d#phi3b3i.'.stato wid Jd.:bil ''y of co.afia.i,~t-~' 1 6. Ba,z.E.F_:: et co.ami#.t,trc. .=,`" 1066- 73}, 20~.~5. Coating FEl in 4'Ãn;~tfk.x tÃ3*2La~ t i~ {~= ~;., i~'z ~' 1 . , ..FÃ:; t7. ':ta }~y*o?hi i:::, e.g., supetbcrd:-caphÃliz_, by UV liL~ht ilaurt..natit,n, wi :~os;Ãroz?

?tcnt 10 caÃ`i inC3i.Ede (c.+t^.s., be'iF3%iF13.racttÃrL'i: #.i't3i7.) TlAtw1ll.3+,:-f7lsltc>.iuk, s':#i..h cii;

~:= itain;~~~ sOd (;, g. 3161.<. BioI)=~~wt, 1 N (l} I~ S S29108). and 304L
swinles:~ sweA. and a-i:
~ L ~~` z~Ãlt: ~ ~i- ~zz af3F1 y 'I%ding s %3~ 'ss steel iiTi~ ~~ 7~ '_~ 3;~fi 3~% weight Z~ eLF~~I 3i3.a ~
~: ted.3'. t. ~l{.< ~ÃT1~.Fx.>¾
z'x ~t; : iÃIc (:. , .., Pfi, iF, Au, YO Ã;)'ERM) a W<.::Ã-iW in à Sr2003-(3(): 8380-A
1.,I_:S 2002-v ; ~ ~, ~'~ r ,~~..
()1447,57-Az, w rs, ?~~is_~ t~~31~'~'0()- Al) ':tii~i~i~.31 Ã~Ã. ~FÃc.kG;-~t.,f~F.~i;:~~F? ~.ll~ ~y` ~ ..~ _~. ~~ll~~;~:~
~
5.~.~~`: <Ã t ~~~sY~'..:.y, L605 a~:;l.?ys. .~:~A~`_a~N5 fiTana::~Frti, fiiats::E.t.n, <Jloss Ti--s.AI-4V T~~:-.'.2::`r 501e::, .-`S~ aOl?:? ~lad:.`3F.Ir.`a, pEc:il,iltl,l2i ra,~~^,i3is, n1ob11Ãrr.k nI;3b'a1:n'a" alloys CÃ?-?~~.'. d~:=az ~ ~....>.#ti:1~.;Ã-~~, ~.~xf~ liklla~~ ~lFÃ;3 ill 'l'~rS. _ t ~t`~.cI' ~.x~ ~:` >~ materials are tx f ettwF.~3.~re " ;F
~. ~~: ~F~'3 ~~y a}~ F1:~ .~, co" 1mif'1ic i.F C giid Aa pl..4:kf Fi,)T3: Vk 10071891ji1C`.t. September 2{3t 20C.B c3F'Ãd , U.S. Application Nc.}. 1::035, 3M filed hina_imy 3, 20:#5. Other nn...teFFa>>
include dilast;..

bi+.i4o}.2iFJ<4.t,bX.c meal .SiSc-:i3lJs -a sWp4*}.Vlas~vic- or pslr.WLYo-4'^lt.F3tÃZ-.. ÃA%Z.^L4Ci altoy?as&.Tc1ibv1.d.
25 ,;~ Sc1 ~.a~sky, L, N-I:,Donald, >>Sh4Fliw '4'Iunory Alloys", Encyclopedia of CltcEi3icai ? . ~` Yft~ I~a i7 M{~ . ''a~.a~ '~:. . ' k~'.~~ r .~z`., r , c~:Ãit ~
~Ãx*:~t::1~:F~F-f3Ã. J S ._~14.# Z',~, .~L ~~.'".1 ~~~+ ~ ,~~L" ='4` & ~ it~
~Z~~, ~"~~~. ~,~. S.t:Ãi`s ~i~`~Ã.iIy }~e A
iiiss:i~~.~3!i:~. 5 ..~~~~fFG.3tF~": `i~c~3~ R,~,"4`~; ~~+,8 filoC~ January F?, 2ii03<

3.Ir sonic eÃ#':b't?dFT.73elais, TtIi3.t'.niilS Rof' illi3f]Lslact,=Ã.ÃÃ 32?
4:::a]i 10 #Ã,a::?Far`so t. I.~:C: or Ã'?7oÃ`Ã.:

in3mz~Ai;lh Ã3u:>:,.Ãxhancd.: visibility byNNIRL l_.xaYnp1cc s. t NIR.: MaÃe?
Ãal4 Ã.:icludo non-60 fiCiI'ou'B rit.,.<1E4 (i.'..g.., '...~ppe", JilvÃ'r. pB:FtI.Ã`ÃuFa3, or gE?lt? ud Ã.:f?F3 ti;i'rL?w, coF3i:iF.F-:ii2;.rj Si3Pd.paf'amFli.f:TÃ:t:tic di~.-mens (d~.!.?., d4qb)i.'C3,,lum or gadoliÃiii:Etn)s.1c}? as i~ii*11. w l!_)l?it7213Ã?2. Al ;';=~"^ei 4;tt%t;`lt` ti, ~^~I ildi,t t`i)71~?llr ~ ~r;= r 10 ,,..r.,Ã;. L
%t3nÃ:3ih,.dS ~~ ,?t'. or Y?: F : ~ ~`-xs s3~.~"a ~ 2 ali~, t~ low ?Iii3~,. t :ry3.~EIG sEa <.sC.~;?f`r:~l:~`~tlt~c > :i:? r,'i~ e,;
~ Ã'i:= .~'liLa~:act1~.~~.. # .ilgpict:.+'.~
suSci*.i~~.~.?~-4' C~t%ri:tc~.4, which t't~ari~i.a~ t~.2~#i~. S}#.~;:y c.~iii~.it4rl C'+:~~:.~b~+'t~~ ;i~~t~r.~.ia.:::. of Si.t7 cai.t}v`.~ E~ ii:~.L~3~oa 1t.#.x'~~#t~ ~~ .~.~R.'. 4tf'.~Ã1t. ~..c~Z'~?
~3t~g$2v~~'L` .`~.`~O..L~~~3?~'i.#ry Ã:;c#fZ.n:i~lt Ã~t.::t}i~v 6 thos;~~d.<.S.:il ie:., cd":i.)'v4, stit:h as WIt'sll:::i417, p::13:{7ifA3, tÃns?1uÃ1I Ã.,:oi:*it.I.en..--:?t`.''p~'3 , a..tA ar3oys , :.~ieIit ,k? can b:'. o~~~a dws:ri d shape a,. .d, Si.`1:C' (c t' coronary s.''~d3.5. .',t?, :rc sft'Ã1t,':
peripheral :'<.{:~iS.:t.ÃEitr `"ti::'#ts" t.s`¾.~(..'s"1t~ i~'~~,~t1l ~.~s~:f:=ii~.` l`>c :i:ti.l~r`i t Y r" 3tw~:~'k.~s`
, . ~.. ~ < Lix'~i* w ~ r , t~~C;~ ~?::~.Ã"3~`.L~~,,.~3Z ; }, Depi:'ia(+ng on thi~'~ aprt?kl#;::'at?b3Ã y~ei]t 10 cit:ihave a dÃirmõ3'.t:;+'t?r g;, abci:: I I11:3';
Fio, al:so?..1~ 46 mm l.-t Le'wi`e3 e7$lE3{3d1.u?:.;...tj., . coronary s'#c;:]t '5..an ha:l`a e an E'~pitndQs.~z~
Lal.mete` of :`"3 Zi abi`tit 2 imll 1i.3 about 6 ?"n-f, It? :i'l?:3ae Gmb,IdÃz??`~v'nts., si ph, .pl:i>w. J``.~ 'zt can have t#n expthd'V`+a d`ziu7?c:tt:-r of from about :' .T?I?' to about 24 n?;.1. ai1 iLi;rtaiÃ:
a .
Tc.k:A. 5~#:i.~~t?st1 i~ca:~ c'II?Si/ t3T' ?,.3~`~,+.~t?~y Wt~~#.?t EJz.:
,~:l::e.
~r an i.. ZA~ `S'c-~-:~.~.'3 +:+:~`
4 4'. . . . . . . . .

~.. . . about ::3 nmm~ tCS i.l-)t;?.t 30 3lita`i, IÃrt soTIz..c i'I2bt?(ail`IC.',r.fs, a Ãii:uf"i?lm~T' !~te.ft %t?f3 hta2's:_ . ain, c ~~~c?t'<~:i,~e i=1s.3~~,~..~i:of ArZIt~ about I ;.722:]~I to about .1 y :Ik3.~?~, ; `i Q~ C.b .~ ~ n~~. 2` ~L.) ?#.~ Y t~~
~ . : . ~#kt..iia ~ ~..>.
(AJ.J.A) .,tWnt[3.?d 3.i7hoAa-4']c C#orC34 S<334u1 k~Yti {,TAA) s}emt: can iaim,e a diameter i\wm about b:O nsan to about 46 mm. SteÃ:`t.. 10 k:aÃ: bc b.`..tilt?f?D i`.,a.paÃ.dtM#. , :t`L'.:` l.'5.m'tn2..ab.(:~, or a c0M:1i.ni3ttf3n of bo#:}i U.S. Patent No, 5K,.>66,504).

Sts i7.t ; t; ck:'. a?z,ludca aoletasE?bIe boÃ?1alcev1~. t,g., a t.#t;rape _,m: ageÃtt, &'iig, f?r a ='_S} .titi4'f,'', o+:)mpoutld., such c,E.'.~ desL,Ilbt'.Sl .3 P<1tC:lt Ntx. 5,6?`4., ? ? ~~_ U.S.

AppsÃcai..>: No. ts9~~~~955,415, fileo, July 2, 2001. aind T_ .;;.
:kp~~~ca:t#on 'No. 10; 2-?2,265_ fil,`'.fs A`xtf'aist _?#:, 2002. The thtrÃ"'sl~"+~k..~tEC: s geIl$:~, drugs, i#' p}3c$#7a'r.Ãci.tit?a.'ci1.` Z active i:om,`t?tl?d., can f:'~ludL fo C:xa.3pl<s anti-proliferative i,z `i:'z`ts, t,~¾l:s:'4~~~:.3~ , z?,t. ,2n'lla-?'"?lattirZ' i:lgeIl e:s, 1mmuli~..3s'uppis..s'5.'4e LE3.xq3i3't,TdS, a.3t.:st:'1el3i;

iy t.~#ii^S..i ~r a 'i.s t?f;~., o.~ .= ~'ti.r~t?l~a,r...lAnl~a ;~ ..1 t Ga~.1;:1.:
2 i Fg'~.i It~.3. and ~~a~t1Jii5~r H ir ~J~+.:;~I~ i:Ai~T~~f~~~~ ?1 ~~Ãt.
in.2..I..axel, pz..ml.i-nus and &..anieÃhasone, A . .3.#:i#:il3t',3' i?f .'.i=.bE3d1nnÃ7Ãits l1:<'l%.o been m:It'.scr1bE,d.
NLveifl"#3:;,:css. :t ~~ i;3.l be understood d'i%1t various i-notilficiati.5'3s 3a23:3y C9`' 1-mE:c w[t~i:io'Ã.It depazt,ng i_rt.?_3> 'Lho sp`.'ÃLaf~ad sctkps' of .hL' : 3..C;< sirc. AGcE?idÃF12 ] othci' z3'i' 3"vf h;]
thwSc2?po of fhe a I. 61low?,i3g u' a d:;s.

~ ~~

Claims (33)

1. A medical device having a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway, wherein said inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure bear a coating of hydrophilic material and said outer abluminal wall surface of the tubular structure bears a coating of hydrophobic material.
2. The medical device of claim 1, wherein at least one or more selected regions of the luminal and side wall surfaces bears a coating of hydrophilic material.
3. The medical device of claim 2, wherein the material is superhydrophilic.
4. The medical device of claim 1, wherein at least one or more selected regions of the abluminal wall surface bears a coating of hydrophobic material.
5. The medical device of claim 1, wherein the coating of the luminal, side and abluminal wall surfaces comprises titanium (+y) oxide (-x).
6. The medical device of claim 5, wherein the coating further comprises a layer of organic compound over titanium (+y) oxide (-x).
7. The medical device of claim 5, wherein the coating upon the abluminal wall surface further comprises a biomolecule.
8. The medical device of claim 7, wherein the coating further comprises a polymer.
9. The medical device of claim 5, wherein the coating upon the luminal and side wall surfaces further comprises a biomolecule.
10. A medical device having a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway, wherein said inner luminal wall surface and side wall surface of the bands and connectors forming transverse passageways through the elongated tubular structure bear a coating of hydrophobic material and said outer abluminal wall surface of the tubular structure bears a coating of hydrophilic material.
11. The medical device of claim 10, wherein at least one or more selected regions of the luminal and side wall surfaces bears a coating of hydrophobic material.
12. The medical device of claim 10, wherein at least one or more selected regions of the abluminal wall surface bears a coating of hydrophilic material.
13. The medical device of claim 12, wherein the material is superhydrophilic.
14. The medical device of claim 10, wherein the coating of the luminal, side and abluminal wall surface comprises titanium (+y) oxide (-x).
15. The medical device of claim 14, wherein the coating further comprises a layer of organic compound over titanium (+y) oxide (-x).
16. The medical device of claim 14, wherein the coating upon the abluminal wall surface further comprises a biomolecule.
17. The medical device of claim 14, wherein the coating upon the luminal and side wall surfaces further comprises a biomolecule.
18 18. The medical device of claim 17, wherein the coating further comprises a polymer.
19. A method of producing a medical device, the method comprising:

(i) coating wall surfaces of a medical device having a body of interconnected bands and connectors forming an elongated tubular structure having an inner luminal wall surface and an outer abluminal wall surface and defining a central lumen or passageway, wherein said inner luminal wall surface and side wall surface of the bands and connectors form transverse passageways through the elongated tubular structure with hydrophilic titanium (+y) oxide (-x);

(ii) exposing the medical device to conditions sufficient to cause the titanium (+y) oxide (-x) coating to become hydrophobic;

(iii) exposing selected surfaces of the medical device to conditions sufficient to cause the titanium (+y) oxide (-x) coating to become superhydrophilic; and (iv) coating the medical device in a first solution compatible with desired biomolecules.
20. The method of claim 19, wherein the first solution comprises at least one polar solvent configured to adhere to hydrophilic surfaces of the medical device and at least one non-polar solvent configured to adhere to the hydrophobic surface of the medical device.
21. The method of claim 20, wherein the solution further comprises at least one biomolecule compatible with at least one solvent.
22. The method of claim 21, wherein the solution further comprises a polymer.
23. The method of claim 19, further comprising coating the medical device in a second solution compatible with desired biomolecules.
24. The method of claim 23, wherein the second solution is non-polar.
25. The method of claim 23, wherein the second solution is polar.
26. The method of claim 23, wherein the second solution comprises a desired biomolecule.
27. The method of claim 26, wherein the second solution comprises a polymer.
28. The method of claim 19, wherein further comprising coating the medical device of step (i) with a layer of organic compound.
29. The method of claim 19, wherein the conditions of step (ii) comprise placing the medical device in a dark environment.
30. The method of claim 19, wherein the conditions of step (iii) comprise illuminating the surfaces of the medical device that bear the titanium (+y) oxide (-x) coating with ultraviolet light.
31. The method of claim 30, wherein at least a region of the luminal and side wall surfaces that bear the coating is illuminated.
32. The method of claim 30, wherein at least a region of the abluminal wall surface that bears the coating is illuminated.
33. The method of claim 30, wherein step (iii) further comprises exposing at least a region of surfaces that have become superhydrophilic to conditions sufficient for the region to become hydrophobic.
CA002655793A 2006-06-29 2007-06-15 Medical devices with selective coating Abandoned CA2655793A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81810106P 2006-06-29 2006-06-29
US60/818,101 2006-06-29
PCT/US2007/071317 WO2008002778A2 (en) 2006-06-29 2007-06-15 Medical devices with selective coating

Publications (1)

Publication Number Publication Date
CA2655793A1 true CA2655793A1 (en) 2008-01-03

Family

ID=38739988

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002655793A Abandoned CA2655793A1 (en) 2006-06-29 2007-06-15 Medical devices with selective coating

Country Status (5)

Country Link
US (1) US8771343B2 (en)
EP (1) EP2032091A2 (en)
JP (1) JP2009542359A (en)
CA (1) CA2655793A1 (en)
WO (1) WO2008002778A2 (en)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US8458879B2 (en) * 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US7758892B1 (en) * 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
US8840660B2 (en) * 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) * 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) * 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) * 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
JP5313882B2 (en) * 2006-05-05 2013-10-09 ソニー コンピュータ エンタテインメント アメリカ リミテッド ライアビリテイ カンパニー Device for displaying main content and auxiliary content
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2008002778A2 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
CA2659761A1 (en) 2006-08-02 2008-02-07 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
JP2010503469A (en) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド Medical device having drug-eluting film
EP2959925B1 (en) * 2006-09-15 2018-08-29 Boston Scientific Limited Medical devices and methods of making the same
US8808726B2 (en) * 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
ES2368125T3 (en) 2006-09-15 2011-11-14 Boston Scientific Scimed, Inc. BIOEROSIONABLE ENDOPROOTHESIS WITH BIOESTABLE INORGANIC LAYERS.
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
CA2663717A1 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Controlling biodegradation of a medical instrument
WO2008036548A2 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
EP2084310A1 (en) * 2006-10-05 2009-08-05 Boston Scientific Limited Polymer-free coatings for medical devices formed by plasma electrolytic deposition
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
WO2008061431A1 (en) * 2006-11-20 2008-05-29 Lepu Medical Technology (Beijing) Co., Ltd. Vessel stent with multi drug-coatings
EP2277563B1 (en) * 2006-12-28 2014-06-25 Boston Scientific Limited Bioerodible endoprostheses and method of making the same
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US8741158B2 (en) 2010-10-08 2014-06-03 Ut-Battelle, Llc Superhydrophobic transparent glass (STG) thin film articles
US7976915B2 (en) * 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2187988B1 (en) 2007-07-19 2013-08-21 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) * 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US8221822B2 (en) * 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
WO2009020520A1 (en) * 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090118809A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) * 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090143855A1 (en) * 2007-11-29 2009-06-04 Boston Scientific Scimed, Inc. Medical Device Including Drug-Loaded Fibers
US20100008970A1 (en) * 2007-12-14 2010-01-14 Boston Scientific Scimed, Inc. Drug-Eluting Endoprosthesis
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) * 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
WO2009148821A2 (en) * 2008-05-29 2009-12-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
US7985252B2 (en) * 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2320829A1 (en) * 2008-07-31 2011-05-18 Boston Scientific Scimed, Inc. Coils for vascular implants or other uses
US8382824B2 (en) * 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8389083B2 (en) * 2008-10-17 2013-03-05 Boston Scientific Scimed, Inc. Polymer coatings with catalyst for medical devices
US8231980B2 (en) * 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8945117B2 (en) 2009-02-11 2015-02-03 Boston Scientific Scimed, Inc. Insulated ablation catheter devices and methods of use
US8267992B2 (en) * 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) * 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
BRPI1009556A2 (en) * 2009-03-06 2019-09-24 Univ California vascular implant, method for generating a super hydrophilic layer on the surface of a vascular implant, method of forming a nickel titanium thin film sheet, hydrophilic nickel titanium thin film sheet, system and method for treating a vascular condition.
US20100274352A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scrimed, Inc. Endoprosthesis with Selective Drug Coatings
US8287937B2 (en) * 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
KR101060607B1 (en) * 2009-07-09 2011-08-31 전남대학교산학협력단 Method of manufacturing drug-releasing stent using titanium oxide thin film coating
US20110022158A1 (en) * 2009-07-22 2011-01-27 Boston Scientific Scimed, Inc. Bioerodible Medical Implants
EP2456481B1 (en) * 2009-07-24 2016-11-23 Boston Scientific Scimed, Inc. Medical devices having an inorganic coating layer formed by atomic layer deposition
WO2011017031A2 (en) * 2009-07-27 2011-02-10 The Regents Of The University Of California Prohealing endovascular devices
US8668732B2 (en) * 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US8920490B2 (en) 2010-05-13 2014-12-30 Boston Scientific Scimed, Inc. Endoprostheses
EP2575675A4 (en) * 2010-05-25 2015-07-29 Univ California Ultra-low fractional area coverage flow diverter for treating aneurysms and vascular diseases
JP2013544954A (en) 2010-09-07 2013-12-19 ボストン サイエンティフィック サイムド,インコーポレイテッド Endoprosthesis containing bioerodible magnesium alloy
US11292919B2 (en) 2010-10-08 2022-04-05 Ut-Battelle, Llc Anti-fingerprint coatings
US9221076B2 (en) 2010-11-02 2015-12-29 Ut-Battelle, Llc Composition for forming an optically transparent, superhydrophobic coating
WO2013040201A2 (en) 2011-09-14 2013-03-21 Boston Scientific Scimed, Inc. Ablation device with multiple ablation modes
CN104039257A (en) 2012-01-10 2014-09-10 波士顿科学医学有限公司 Electrophysiology system
EP2809253B8 (en) 2012-01-31 2016-09-21 Boston Scientific Scimed, Inc. Ablation probe with fluid-based acoustic coupling for ultrasonic tissue imaging
JP6392250B2 (en) 2013-02-15 2018-09-19 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Biodegradable endoprosthesis and method of processing biodegradable magnesium alloy used therein
WO2015066181A1 (en) 2013-10-29 2015-05-07 Boston Scientific Scimed, Inc. Bioerodible magnesium alloy microstructures for endoprostheses
US20150239773A1 (en) 2014-02-21 2015-08-27 Ut-Battelle, Llc Transparent omniphobic thin film articles
GB2523814A (en) * 2014-03-07 2015-09-09 Nobel Biocare Services Ag Implant surface composition
US10828400B2 (en) 2014-06-10 2020-11-10 The Research Foundation For The State University Of New York Low temperature, nanostructured ceramic coatings
JP2017529169A (en) 2014-10-13 2017-10-05 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Tissue diagnosis and treatment using mini-electrodes
WO2016065337A1 (en) 2014-10-24 2016-04-28 Boston Scientific Scimed Inc. Medical devices with a flexible electrode assembly coupled to an ablation tip
EP3034033A1 (en) 2014-12-16 2016-06-22 Nobel Biocare Services AG Dental implant
CN106999080B (en) 2014-12-18 2020-08-18 波士顿科学医学有限公司 Real-time morphological analysis for lesion assessment
WO2016145368A1 (en) 2015-03-11 2016-09-15 Boston Scientific Scimed, Inc. Bioerodible magnesium alloy microstructures for endoprostheses
US10661261B2 (en) 2015-03-13 2020-05-26 The Research Foundation For The State University Of New York Metal oxide nanofibrous materials for photodegradation of environmental toxins
CN106310376B (en) * 2015-06-30 2020-06-12 先健科技(深圳)有限公司 Implanted medical device prefabricated part, implanted medical device and preparation method thereof
US20170220570A1 (en) * 2016-01-28 2017-08-03 Echostar Technologies L.L.C. Adjusting media content based on collected viewer data
KR101653535B1 (en) * 2016-05-31 2016-09-05 전남대학교병원 Polymer-Free Everolimus-Eluting Coronary Stent Fabricated by Electrospinning Technique
GB2559756B (en) * 2017-02-16 2022-05-04 Cook Medical Technologies Llc Implantable medical device with differentiated luminal and abluminal characteristics
US11242468B2 (en) * 2017-10-17 2022-02-08 Indian Institute Of Technology Madras (Itt Madras) Aqueous composition and a method of producing durable and extremely efficient water repelling superhydrophobic materials at ambient condition thereof
WO2019136382A1 (en) 2018-01-05 2019-07-11 Laslo Olah Hearing aid and method for use of same
US11095992B2 (en) * 2018-01-05 2021-08-17 Texas Institute Of Science, Inc. Hearing aid and method for use of same

Family Cites Families (938)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT232704B (en) 1959-03-31 1964-04-10 Plastic Textile Access Ltd Device for extrusion
DE1646502C3 (en) 1968-01-08 1974-10-17 Dyckerhoff Zementwerke Ag, 6200 Wiesbaden Waterproof cement
SU393044A1 (en) 1968-09-03 1973-08-10 METHOD OF REINFORCEMENT OF METAL PRODUCTS BY GRAIN SOLID
US3751283A (en) 1971-03-08 1973-08-07 Remington Arms Co Inc Armored metal tools and production thereof
US3758396A (en) 1971-08-31 1973-09-11 Research Corp Ition preparation of immobilized enzymemembrane complexes by electrocodepos
US3948254A (en) 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US3910819A (en) 1974-02-19 1975-10-07 California Inst Of Techn Treatment of surfaces to stimulate biological cell adhesion and growth
US3970445A (en) 1974-05-02 1976-07-20 Caterpillar Tractor Co. Wear-resistant alloy, and method of making same
GB1527592A (en) 1974-08-05 1978-10-04 Ici Ltd Wound dressing
US3993072A (en) 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
US3952334A (en) 1974-11-29 1976-04-27 General Atomic Company Biocompatible carbon prosthetic devices
US4101984A (en) 1975-05-09 1978-07-25 Macgregor David C Cardiovascular prosthetic devices and implants with porous systems
DE2620907C3 (en) 1976-05-12 1984-09-20 Battelle-Institut E.V., 6000 Frankfurt Anchoring for highly stressed endoprostheses
US4143661A (en) 1977-12-12 1979-03-13 Andros Incorporated Power supply for body implant and method for operation
SE416175B (en) 1979-03-07 1980-12-08 Per Ingvar Branemark FOR IMPLANTATION IN BODY TISSUE Separate Bone Tissue, Dedicated Material
US4237559A (en) 1979-05-11 1980-12-09 General Electric Company Bone implant embodying a composite high and low density fired ceramic construction
US4334327A (en) 1979-12-21 1982-06-15 University Of Utah Ureteral prosthesis
US4321311A (en) 1980-01-07 1982-03-23 United Technologies Corporation Columnar grain ceramic thermal barrier coatings
US4309996A (en) * 1980-04-28 1982-01-12 Alza Corporation System with microporous releasing diffusor
US4308868A (en) * 1980-05-27 1982-01-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Implantable electrical device
CH649578A5 (en) 1981-03-27 1985-05-31 Ulvac Corp HIGH-SPEED CATHODE SPRAYING DEVICE.
US4475972A (en) 1981-10-01 1984-10-09 Ontario Research Foundation Implantable material
US5968640A (en) 1985-04-23 1999-10-19 The Boeing Company Conductive, thermally stable oligomers
US4407695A (en) 1981-12-31 1983-10-04 Exxon Research And Engineering Co. Natural lithographic fabrication of microstructures over large areas
SE445884B (en) 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4587121A (en) 1983-06-14 1986-05-06 Miles Laboratories, Inc. High titer Pseudomonas immune serum globulin
US4565744A (en) * 1983-11-30 1986-01-21 Rockwell International Corporation Wettable coating for reinforcement particles of metal matrix composite
US4657544A (en) 1984-04-18 1987-04-14 Cordis Corporation Cardiovascular graft and method of forming same
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
DE3516411A1 (en) 1985-05-07 1986-11-13 Plasmainvent AG, Zug COATING OF AN IMPLANT BODY
US4665896A (en) 1985-07-22 1987-05-19 Novacor Medical Corporation Power supply for body implant and method of use
US4705502A (en) 1985-11-06 1987-11-10 The Kendall Company Suprapubic catheter with dual balloons
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4738740A (en) 1985-11-21 1988-04-19 Corvita Corporation Method of forming implantable vascular grafts
US4743252A (en) 1986-01-13 1988-05-10 Corvita Corporation Composite grafts
DE3608158A1 (en) 1986-03-12 1987-09-17 Braun Melsungen Ag VESSELED PROSTHESIS IMPREGNATED WITH CROSSLINED GELATINE AND METHOD FOR THE PRODUCTION THEREOF
GB2189738B (en) 1986-03-24 1989-11-15 Ethicon Inc Apparatus for producing fibrous structures electrostatically
SE453258B (en) 1986-04-21 1988-01-25 Medinvent Sa ELASTIC, SELF-EXPANDING PROTEST AND PROCEDURE FOR ITS MANUFACTURING
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US4886062A (en) 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
DE3821544C2 (en) 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatation catheter
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5163958A (en) 1989-02-02 1992-11-17 Cordis Corporation Carbon coated tubular endoprosthesis
JPH02279575A (en) 1989-04-18 1990-11-15 Nkk Corp Production of sintered ceramic body having dense ceramic film
US4994071A (en) * 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5073365A (en) 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
US5061914A (en) 1989-06-27 1991-10-29 Tini Alloy Company Shape-memory alloy micro-actuator
DE69027061T2 (en) 1989-06-30 1997-01-02 Tdk Corp Substitute material for living hard tissue, its manufacture and manufacture of a shaped body
US5649951A (en) 1989-07-25 1997-07-22 Smith & Nephew Richards, Inc. Zirconium oxide and zirconium nitride coated stents
DK0420488T3 (en) 1989-09-25 1993-08-30 Schneider Usa Inc Multilayer extrusion as a method for preparing angioplasty balloons
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5843089A (en) 1990-12-28 1998-12-01 Boston Scientific Corporation Stent lining
US5439446A (en) 1994-06-30 1995-08-08 Boston Scientific Corporation Stent and therapeutic delivery system
US5477864A (en) 1989-12-21 1995-12-26 Smith & Nephew Richards, Inc. Cardiovascular guidewire of enhanced biocompatibility
US5171607A (en) 1990-01-29 1992-12-15 Bausch & Lomb Incorporated Method of depositing diamond-like carbon film onto a substrate having a low melting temperature
US5378146A (en) * 1990-02-07 1995-01-03 Ormco Corporation Polyurethane biomedical devices & method of making same
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
EP0484533B1 (en) 1990-05-19 1995-01-25 Anatoly Nikiforovich Papyrin Method and device for coating
US5587507A (en) 1995-03-31 1996-12-24 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
US5120322A (en) 1990-06-13 1992-06-09 Lathrotec, Inc. Method and apparatus for treatment of fibrotic lesions
US5102403A (en) 1990-06-18 1992-04-07 Eckhard Alt Therapeutic medical instrument for insertion into body
US4976692A (en) 1990-09-13 1990-12-11 Travenol Laboratories (Israel) Ltd. Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus
US5258020A (en) 1990-09-14 1993-11-02 Michael Froix Method of using expandable polymeric stent with memory
US5160790A (en) 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5205921A (en) 1991-02-04 1993-04-27 Queen's University At Kingston Method for depositing bioactive coatings on conductive substrates
DE4104359A1 (en) * 1991-02-13 1992-08-20 Implex Gmbh CHARGING SYSTEM FOR IMPLANTABLE HOERHILFEN AND TINNITUS MASKERS
US5195969A (en) 1991-04-26 1993-03-23 Boston Scientific Corporation Co-extruded medical balloons and catheter using such balloons
US5326354A (en) 1991-05-09 1994-07-05 Howmedica Inc. Method for forming attachment surfaces on implants
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5258098A (en) 1991-06-17 1993-11-02 Cycam, Inc. Method of production of a surface adapted to promote adhesion
US5242706A (en) 1991-07-31 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Laser-deposited biocompatible films and methods and apparatuses for producing same
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5219611A (en) 1991-09-30 1993-06-15 Cornell Research Foundation, Inc. Preparing densified low porosity titania sol gel forms
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
WO1993006792A1 (en) 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5366504A (en) 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
WO1993007924A1 (en) 1991-10-18 1993-04-29 Spire Corporation Bactericidal coatings for implants
US6001289A (en) * 1991-12-04 1999-12-14 Materials Innovation, Inc. Acid assisted cold welding and intermetallic formation
US5314453A (en) 1991-12-06 1994-05-24 Spinal Cord Society Position sensitive power transfer antenna
US5348553A (en) 1991-12-18 1994-09-20 Whitney Douglass G Method for promoting blood vessel healing
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US6071567A (en) 1992-03-25 2000-06-06 Reeves Brothers, Inc. Formation of compressible ply containing high melting point thermoplastic microspheres and printing blankets comprising same
DE69332950T2 (en) 1992-03-31 2004-05-13 Boston Scientific Corp., Natick BLOOD VESSEL FILTER
US5807407A (en) 1992-05-04 1998-09-15 Biomet, Inc. Medical implant device and method for making same
IL106013A (en) 1992-07-13 1994-12-29 Litton Systems Inc Flip-up mount for night vision system
CA2074318A1 (en) * 1992-07-22 1994-01-23 Morteza Shirkhanzadeh Prosthetic implant with self-generated current for early fixation in skeletal bone
US5614549A (en) 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5322520A (en) 1992-11-12 1994-06-21 Implemed, Inc. Iontophoretic structure for medical devices
ES2166370T3 (en) 1993-01-19 2002-04-16 Schneider Usa Inc IMPLANTABLE FILAMENT IN COMPOSITE MATERIAL.
US5607463A (en) 1993-03-30 1997-03-04 Medtronic, Inc. Intravascular medical device
US5380298A (en) * 1993-04-07 1995-01-10 The United States Of America As Represented By The Secretary Of The Navy Medical device with infection preventing feature
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5824048A (en) 1993-04-26 1998-10-20 Medtronic, Inc. Method for delivering a therapeutic substance to a body lumen
US5368881A (en) 1993-06-10 1994-11-29 Depuy, Inc. Prosthesis with highly convoluted surface
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US6776094B1 (en) 1993-10-04 2004-08-17 President & Fellows Of Harvard College Kit For Microcontact Printing
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
US5397307A (en) 1993-12-07 1995-03-14 Schneider (Usa) Inc. Drug delivery PTCA catheter and method for drug delivery
US5788687A (en) 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
JPH07257079A (en) 1994-03-25 1995-10-09 Dainippon Printing Co Ltd Optical card
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5788979A (en) 1994-07-22 1998-08-04 Inflow Dynamics Inc. Biodegradable coating with inhibitory properties for application to biocompatible materials
US6514289B1 (en) 2000-01-30 2003-02-04 Diamicron, Inc. Diamond articulation surface for use in a prosthetic joint
US6497727B1 (en) 2000-01-30 2002-12-24 Diamicron, Inc. Component for use in prosthetic hip, the component having a polycrystalline diamond articulation surface and a plurality of substrate layers
US5504385A (en) 1994-08-31 1996-04-02 At&T Corp. Spaced-gate emission device and method for making same
US5891108A (en) 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US5649977A (en) 1994-09-22 1997-07-22 Advanced Cardiovascular Systems, Inc. Metal reinforced polymer stent
EP0705911B1 (en) * 1994-10-04 2001-12-05 General Electric Company Thermal barrier coating
BE1008955A3 (en) 1994-11-14 1996-10-01 Univ Catholique Louvain Process for obtaining and products obtained biomaterials.
CA2301351C (en) 1994-11-28 2002-01-22 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
US5755722A (en) 1994-12-22 1998-05-26 Boston Scientific Corporation Stent placement device with medication dispenser and method
US6017577A (en) * 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
DE19506188C2 (en) 1995-02-22 2003-03-06 Miladin Lazarov Implant and its use
US7204848B1 (en) 1995-03-01 2007-04-17 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US6306144B1 (en) 1996-11-01 2001-10-23 Scimed Life Systems, Inc. Selective coating of a balloon catheter with lubricious material for stent deployment
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
AU4952096A (en) 1995-04-19 1996-11-07 Schneider (Usa) Inc. Drug release coated stent
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5795626A (en) 1995-04-28 1998-08-18 Innovative Technology Inc. Coating or ablation applicator with a debris recovery attachment
DE69634013T2 (en) 1995-05-26 2005-12-15 SurModics, Inc., Eden Prairie PROCESS AND IMPLANTABLE OBJECT FOR PROMOTING ENDOTHELIALIZATION
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7550005B2 (en) 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
ATE224394T1 (en) 1995-06-16 2002-10-15 Kyowa Hakko Kogyo Kk DERIVATIVES OF DC 107
US6209621B1 (en) 1995-07-07 2001-04-03 Depuy Orthopaedics, Inc. Implantable prostheses with metallic porous bead preforms applied during casting and method of forming the same
US6846493B2 (en) * 1995-09-01 2005-01-25 Millenium Biologix Inc. Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity
CN1183058C (en) 1995-09-01 2005-01-05 米列姆·贝尔罗吉克公司 Artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity
US5758562A (en) 1995-10-11 1998-06-02 Schneider (Usa) Inc. Process for manufacturing braided composite prosthesis
US5603556A (en) * 1995-11-20 1997-02-18 Technical Services And Marketing, Inc. Rail car load sensor
DE19544750A1 (en) 1995-11-30 1997-06-05 Christoph Rehberg Implantable device with internal electrode to promote tissue growth
DE69621826T2 (en) 1995-12-14 2003-01-23 Imperial College FILM OR LAYER DEPOSITION AND POWDER MANUFACTURE
US5852088A (en) 1995-12-27 1998-12-22 Exxon Research And Engineering Company Nanoporous ceramics with catalytic functionality
US5874134A (en) * 1996-01-29 1999-02-23 Regents Of The University Of Minnesota Production of nanostructured materials by hypersonic plasma particle deposition
US5672242A (en) 1996-01-31 1997-09-30 Integrated Device Technology, Inc. High selectivity nitride to oxide etch process
US5772864A (en) 1996-02-23 1998-06-30 Meadox Medicals, Inc. Method for manufacturing implantable medical devices
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
CA2199890C (en) 1996-03-26 2002-02-05 Leonard Pinchuk Stents and stent-grafts having enhanced hoop strength and methods of making the same
US20040225347A1 (en) 2000-06-05 2004-11-11 Lang G. David Intravascular stent with increasing coating retaining capacity
US5922021A (en) 1996-04-26 1999-07-13 Jang; G. David Intravascular stent
US6241760B1 (en) 1996-04-26 2001-06-05 G. David Jang Intravascular stent
US6783543B2 (en) 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
AU3115897A (en) 1996-04-26 1997-11-19 G. David Jang Intravascular stent
US20040106985A1 (en) 1996-04-26 2004-06-03 Jang G. David Intravascular stent
US5888591A (en) 1996-05-06 1999-03-30 Massachusetts Institute Of Technology Chemical vapor deposition of fluorocarbon polymer thin films
US5951881A (en) 1996-07-22 1999-09-14 President And Fellows Of Harvard College Fabrication of small-scale cylindrical articles
US5830480A (en) 1996-05-09 1998-11-03 The Trustees Of The University Of Pennsylvania Stabilization of sol-gel derived silica-based glass
EP0806211B1 (en) 1996-05-10 2002-10-23 IsoTis N.V. Implant material and process for producing it
US6764690B2 (en) * 1996-05-29 2004-07-20 Delsitech Oy Dissolvable oxides for biological applications
US5693928A (en) 1996-06-27 1997-12-02 International Business Machines Corporation Method for producing a diffusion barrier and polymeric article having a diffusion barrier
US5769884A (en) 1996-06-27 1998-06-23 Cordis Corporation Controlled porosity endovascular implant
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5741331A (en) 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US6174329B1 (en) 1996-08-22 2001-01-16 Advanced Cardiovascular Systems, Inc. Protective coating for a stent with intermediate radiopaque coating
US6756060B1 (en) 1996-09-19 2004-06-29 Usbiomaterials Corp. Anti-inflammatory and antimicrobial uses for bioactive glass compositions
EP1275352A3 (en) 1996-09-20 2003-06-11 Converge Medical, Inc. Radially expanding prostheses and systems for their deployment
US6074135A (en) 1996-09-25 2000-06-13 Innovative Technologies, Inc. Coating or ablation applicator with debris recovery attachment
US5761775A (en) 1996-10-17 1998-06-09 Legome; Mark J. Mushroom and loop material closure system for high shear strength and low peel strength applications
US5824045A (en) 1996-10-21 1998-10-20 Inflow Dynamics Inc. Vascular and endoluminal stents
US6387121B1 (en) 1996-10-21 2002-05-14 Inflow Dynamics Inc. Vascular and endoluminal stents with improved coatings
US6099561A (en) 1996-10-21 2000-08-08 Inflow Dynamics, Inc. Vascular and endoluminal stents with improved coatings
US6530951B1 (en) 1996-10-24 2003-03-11 Cook Incorporated Silver implantable medical device
US6331289B1 (en) * 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US6106473A (en) 1996-11-06 2000-08-22 Sts Biopolymers, Inc. Echogenic coatings
ZA9710342B (en) 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5871437A (en) * 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US6780491B1 (en) 1996-12-12 2004-08-24 Micron Technology, Inc. Microstructures including hydrophilic particles
IT1289815B1 (en) 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS
US6013591A (en) * 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
US5980551A (en) 1997-02-07 1999-11-09 Endovasc Ltd., Inc. Composition and method for making a biodegradable drug delivery stent
AU6657098A (en) 1997-02-12 1998-08-26 Prolifix Medical, Inc. Apparatus for removal of material from stents
ES2130062B1 (en) 1997-02-19 2000-04-01 Pons Creus Joan Maria ELECTRODE SUPPORT FOR CARDIOLOGY.
WO1998036784A1 (en) 1997-02-20 1998-08-27 Cook Incorporated Coated implantable medical device
US20020133222A1 (en) 1997-03-05 2002-09-19 Das Gladwin S. Expandable stent having a plurality of interconnected expansion modules
CA2282748C (en) 1997-03-05 2007-11-20 Boston Scientific Limited Conformal laminate stent device
WO1998042277A1 (en) 1997-03-25 1998-10-01 Jang G David Intravascular stent
US5954724A (en) 1997-03-27 1999-09-21 Davidson; James A. Titanium molybdenum hafnium alloys for medical implants and devices
BR9808109A (en) 1997-03-31 2000-03-08 Neorx Corp Therapeutic smooth muscle vascular cell inhibitor
US6210715B1 (en) 1997-04-01 2001-04-03 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
US5977204A (en) 1997-04-11 1999-11-02 Osteobiologics, Inc. Biodegradable implant material comprising bioactive ceramic
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
IT1292295B1 (en) 1997-04-29 1999-01-29 Sorin Biomedica Cardio Spa ANGIOPLASTIC STENT
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US5891192A (en) 1997-05-22 1999-04-06 The Regents Of The University Of California Ion-implanted protein-coated intralumenal implants
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
GB2325934A (en) 1997-06-03 1998-12-09 Polybiomed Ltd Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US5749809A (en) 1997-06-20 1998-05-12 Lin; Ting Fung Stepping and swinging exerciser
US20020169493A1 (en) 1997-07-10 2002-11-14 Widenhouse Christopher W. Anti-thrombogenic coatings for biomedical devices
US5817046A (en) 1997-07-14 1998-10-06 Delcath Systems, Inc. Apparatus and method for isolated pelvic perfusion
FR2766092B1 (en) 1997-07-16 1999-10-08 Centre Nat Rech Scient IMPLANTABLE DEVICE COATED WITH A POLYMER CAPABLE OF RELEASING BIOLOGICALLY ACTIVE SUBSTANCES
DE19731021A1 (en) * 1997-07-18 1999-01-21 Meyer Joerg In vivo degradable metallic implant
JP3411559B2 (en) 1997-07-28 2003-06-03 マサチューセッツ・インスティチュート・オブ・テクノロジー Pyrolytic chemical vapor deposition of silicone films.
US5980564A (en) 1997-08-01 1999-11-09 Schneider (Usa) Inc. Bioabsorbable implantable endoprosthesis with reservoir
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US5899935A (en) 1997-08-04 1999-05-04 Schneider (Usa) Inc. Balloon expandable braided stent with restraint
US6342507B1 (en) * 1997-09-05 2002-01-29 Isotechnika, Inc. Deuterated rapamycin compounds, method and uses thereof
US6884429B2 (en) 1997-09-05 2005-04-26 Isotechnika International Inc. Medical devices incorporating deuterated rapamycin for controlled delivery thereof
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6273908B1 (en) 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
US6551353B1 (en) 1997-10-28 2003-04-22 Hills, Inc. Synthetic fibers for medical use and method of making the same
US6309414B1 (en) 1997-11-04 2001-10-30 Sorin Biomedica Cardio S.P.A. Angioplasty stents
CA2308177C (en) 1997-11-07 2005-01-25 Expandable Grafts Partnership Intravascular stent and method for manufacturing an intravascular stent
DE69842217D1 (en) 1997-11-07 2011-05-19 State University Radiopaque polymeric biomaterials
NO311781B1 (en) * 1997-11-13 2002-01-28 Medinol Ltd Metal multilayer stents
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
US6077413A (en) 1998-02-06 2000-06-20 The Cleveland Clinic Foundation Method of making a radioactive stent
US6120660A (en) 1998-02-11 2000-09-19 Silicon Genesis Corporation Removable liner design for plasma immersion ion implantation
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6139585A (en) 1998-03-11 2000-10-31 Depuy Orthopaedics, Inc. Bioactive ceramic coating and method
US6187037B1 (en) * 1998-03-11 2001-02-13 Stanley Satz Metal stent containing radioactivatable isotope and method of making same
US6736849B2 (en) 1998-03-11 2004-05-18 Depuy Products, Inc. Surface-mineralized spinal implants
US7547445B2 (en) 1998-03-19 2009-06-16 Surmodics, Inc. Crosslinkable macromers
US20040254635A1 (en) 1998-03-30 2004-12-16 Shanley John F. Expandable medical device for delivery of beneficial agent
EP1702586B1 (en) 1998-03-30 2008-08-06 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US5980566A (en) 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
DE19916086B4 (en) 1998-04-11 2004-11-11 Inflow Dynamics Inc. Implantable prosthesis, especially vascular prosthesis (stent)
US6364856B1 (en) 1998-04-14 2002-04-02 Boston Scientific Corporation Medical device with sponge coating for controlled drug release
US20030040790A1 (en) 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US20020099438A1 (en) 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
US6436133B1 (en) 1998-04-15 2002-08-20 Joseph G. Furst Expandable graft
US6206916B1 (en) 1998-04-15 2001-03-27 Joseph G. Furst Coated intraluminal graft
US6270831B2 (en) 1998-04-30 2001-08-07 Medquest Products, Inc. Method and apparatus for providing a conductive, amorphous non-stick coating
DE69935716T2 (en) 1998-05-05 2007-08-16 Boston Scientific Ltd., St. Michael STENT WITH SMOOTH ENDS
US6280411B1 (en) 1998-05-18 2001-08-28 Scimed Life Systems, Inc. Localized delivery of drug agents
US6206283B1 (en) 1998-12-23 2001-03-27 At&T Corp. Method and apparatus for transferring money via a telephone call
EP0966979B1 (en) 1998-06-25 2006-03-08 Biotronik AG Implantable bioresorbable support for the vascular walls, in particular coronary stent
US6122564A (en) 1998-06-30 2000-09-19 Koch; Justin Apparatus and methods for monitoring and controlling multi-layer laser cladding
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6652581B1 (en) 1998-07-07 2003-11-25 Boston Scientific Scimed, Inc. Medical device with porous surface for controlled drug release and method of making the same
US6022812A (en) * 1998-07-07 2000-02-08 Alliedsignal Inc. Vapor deposition routes to nanoporous silica
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US20010032011A1 (en) 1999-07-20 2001-10-18 Stanford Ulf Harry Expandable stent with array of relief cuts
US20020038146A1 (en) 1998-07-29 2002-03-28 Ulf Harry Expandable stent with relief cuts for carrying medicines and other materials
US20040088041A1 (en) 1999-07-20 2004-05-06 Stanford Ulf Harry Expandable stent with array of relief cuts
WO2000010622A1 (en) 1998-08-20 2000-03-02 Cook Incorporated Coated implantable medical device
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US7235096B1 (en) 1998-08-25 2007-06-26 Tricardia, Llc Implantable device for promoting repair of a body lumen
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
IL142132A0 (en) 1998-09-23 2002-03-10 Phycogen Inc Methods and compositions for treating receptor mediated diseases
US6206915B1 (en) 1998-09-29 2001-03-27 Medtronic Ave, Inc. Drug storing and metering stent
US6245104B1 (en) 1999-02-28 2001-06-12 Inflow Dynamics Inc. Method of fabricating a biocompatible stent
US6217607B1 (en) 1998-10-20 2001-04-17 Inflow Dynamics Inc. Premounted stent delivery system for small vessels
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
DE19855421C2 (en) 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implant
US6348960B1 (en) 1998-11-06 2002-02-19 Kimotot Co., Ltd. Front scattering film
US6214042B1 (en) 1998-11-10 2001-04-10 Precision Vascular Systems, Inc. Micro-machined stent for vessels, body ducts and the like
US6361780B1 (en) 1998-11-12 2002-03-26 Cardiac Pacemakers, Inc. Microporous drug delivery system
US20010014821A1 (en) 1998-11-16 2001-08-16 Mohamad Ike Juman Balloon catheter and stent delivery system having enhanced stent retention
US6984404B1 (en) * 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
US20020077520A1 (en) 1998-11-18 2002-06-20 Jerome Segal Device and method for dilating and irradiating a vascular segment or body passageway
US6063101A (en) 1998-11-20 2000-05-16 Precision Vascular Systems, Inc. Stent apparatus and method
CN1145632C (en) * 1998-11-26 2004-04-14 因芬尼昂技术股份公司 Complex compound of element of sub-group IV
US20070219642A1 (en) 1998-12-03 2007-09-20 Jacob Richter Hybrid stent having a fiber or wire backbone
US20060178727A1 (en) 1998-12-03 2006-08-10 Jacob Richter Hybrid amorphous metal alloy stent
EP1316323A1 (en) 1998-12-31 2003-06-04 Angiotech Pharmaceuticals, Inc. Stent grafts with bioactive coatings
US6955661B1 (en) 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6383519B1 (en) 1999-01-26 2002-05-07 Vita Special Purpose Corporation Inorganic shaped bodies and methods for their production and use
AU2514900A (en) 1999-01-27 2000-08-18 United States Of America As Represented By The Secretary Of The Navy, The Fabrication of conductive/non-conductive nanocomposites by laser evaporation
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
DE19948783C2 (en) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implant
US6558422B1 (en) 1999-03-26 2003-05-06 University Of Washington Structures having coated indentations
US6312457B1 (en) 1999-04-01 2001-11-06 Boston Scientific Corporation Intraluminal lining
US6325825B1 (en) 1999-04-08 2001-12-04 Cordis Corporation Stent with variable wall thickness
US6607598B2 (en) 1999-04-19 2003-08-19 Scimed Life Systems, Inc. Device for protecting medical devices during a coating process
US6368658B1 (en) 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
US6461731B1 (en) * 1999-05-03 2002-10-08 Guardian Industries Corp. Solar management coating system including protective DLC
US6726712B1 (en) 1999-05-14 2004-04-27 Boston Scientific Scimed Prosthesis deployment device with translucent distal end
US6610035B2 (en) 1999-05-21 2003-08-26 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising a hybrid top coat
US7171263B2 (en) 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
US6139913A (en) 1999-06-29 2000-10-31 National Center For Manufacturing Sciences Kinetic spray coating method and apparatus
US6504292B1 (en) * 1999-07-15 2003-01-07 Agere Systems Inc. Field emitting device comprising metallized nanostructures and method for making the same
IT1307263B1 (en) 1999-08-05 2001-10-30 Sorin Biomedica Cardio Spa ANGIOPLASTIC STENT WITH RESTENOSIS ANTAGONIST ACTION, RELATED KIT AND COMPONENTS.
US6458162B1 (en) 1999-08-13 2002-10-01 Vita Special Purpose Corporation Composite shaped bodies and methods for their production and use
US6869701B1 (en) 1999-08-16 2005-03-22 Carolyn Aita Self-repairing ceramic coatings
US6713119B2 (en) 1999-09-03 2004-03-30 Advanced Cardiovascular Systems, Inc. Biocompatible coating for a prosthesis and a method of forming the same
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6379381B1 (en) 1999-09-03 2002-04-30 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
US6287628B1 (en) 1999-09-03 2001-09-11 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
EP1214108B1 (en) 1999-09-03 2007-01-10 Advanced Cardiovascular Systems, Inc. A porous prosthesis and a method of depositing substances into the pores
JP2001098308A (en) 1999-09-24 2001-04-10 Asahi Optical Co Ltd Porous calcium phosphate series compound/metal composite sintered body and producing method
US6845212B2 (en) 1999-10-08 2005-01-18 3M Innovative Properties Company Optical element having programmed optical structures
DE19950386A1 (en) 1999-10-19 2001-05-10 Miladin Lazarov Biocompatible item
DE19951477A1 (en) 1999-10-26 2001-05-03 Biotronik Mess & Therapieg Stent
US6733513B2 (en) 1999-11-04 2004-05-11 Advanced Bioprosthetic Surfaces, Ltd. Balloon catheter having metal balloon and method of making same
US6761736B1 (en) 1999-11-10 2004-07-13 St. Jude Medical, Inc. Medical article with a diamond-like carbon coated polymer
WO2001035928A1 (en) 1999-11-17 2001-05-25 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
AU2004202073B2 (en) 1999-11-17 2007-01-04 Boston Scientific Limited Microfabricated devices for the delivery of molecules into a carrier fluid
US6337076B1 (en) * 1999-11-17 2002-01-08 Sg Licensing Corporation Method and composition for the treatment of scars
US6416820B1 (en) 1999-11-19 2002-07-09 Epion Corporation Method for forming carbonaceous hard film
US6849085B2 (en) 1999-11-19 2005-02-01 Advanced Bio Prosthetic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same
US7195641B2 (en) 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
US7335426B2 (en) 1999-11-19 2008-02-26 Advanced Bio Prosthetic Surfaces, Ltd. High strength vacuum deposited nitinol alloy films and method of making same
US7235092B2 (en) 1999-11-19 2007-06-26 Advanced Bio Prosthetic Surfaces, Ltd. Guidewires and thin film catheter-sheaths and method of making same
US6936066B2 (en) 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US6379383B1 (en) 1999-11-19 2002-04-30 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal device exhibiting improved endothelialization and method of manufacture thereof
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
US6458153B1 (en) 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20060013850A1 (en) * 1999-12-03 2006-01-19 Domb Abraham J Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6479418B2 (en) 1999-12-16 2002-11-12 Isotis N.V. Porous ceramic body
US6613432B2 (en) * 1999-12-22 2003-09-02 Biosurface Engineering Technologies, Inc. Plasma-deposited coatings, devices and methods
US6908624B2 (en) 1999-12-23 2005-06-21 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6471721B1 (en) 1999-12-30 2002-10-29 Advanced Cardiovascular Systems, Inc. Vascular stent having increased radiopacity and method for making same
US6967023B1 (en) 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
ATE460951T1 (en) * 2000-01-25 2010-04-15 Edwards Lifesciences Corp RELEASE SYSTEMS FOR THE TREATMENT OF RESTENOSIS AND ANASTOMOTIC INTIMAL HYPERPLASIA
JP2005503178A (en) * 2000-01-25 2005-02-03 ボストン サイエンティフィック リミテッド Manufacturing medical devices by vapor deposition
US6367412B1 (en) 2000-02-17 2002-04-09 Applied Materials, Inc. Porous ceramic liner for a plasma source
CA2337565A1 (en) 2000-02-25 2001-08-25 Cordis Corporation Use of cladribine on a stent to prevent restenosis
US6440503B1 (en) 2000-02-25 2002-08-27 Scimed Life Systems, Inc. Laser deposition of elements onto medical devices
EP1132058A1 (en) 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US20160287708A9 (en) 2000-03-15 2016-10-06 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
WO2001068270A2 (en) 2000-03-16 2001-09-20 Volkswagen Aktiengesellschaft Method for removing minor lacquer imperfections
US6695865B2 (en) 2000-03-20 2004-02-24 Advanced Bio Prosthetic Surfaces, Ltd. Embolic protection device
US6315708B1 (en) 2000-03-31 2001-11-13 Cordis Corporation Stent with self-expanding end sections
US6527801B1 (en) 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US7066234B2 (en) 2001-04-25 2006-06-27 Alcove Surfaces Gmbh Stamping tool, casting mold and methods for structuring a surface of a work piece
US6327504B1 (en) 2000-05-10 2001-12-04 Thoratec Corporation Transcutaneous energy transfer with circuitry arranged to avoid overheating
US9566148B2 (en) 2000-05-12 2017-02-14 Vactronix Scientific, Inc. Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US6395325B1 (en) 2000-05-16 2002-05-28 Scimed Life Systems, Inc. Porous membranes
EP1359865B1 (en) 2000-05-19 2006-11-22 Advanced Bio Prosthetic Surfaces, Ltd. Methods and apparatus for manufacturing an intravascular stent
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
KR100360364B1 (en) 2000-05-22 2002-11-13 주식회사 정성메디칼 A metal stent for installation in the coronary artery
US6395326B1 (en) 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
US20040211362A1 (en) 2000-05-31 2004-10-28 Daniel Castro System for coating a stent
US6986818B2 (en) 2000-06-02 2006-01-17 The Regents Of The University Of California Method for producing nanostructured metal-oxides
US6418337B1 (en) 2000-06-15 2002-07-09 Autolitt Inc. MRI guided hyperthermia surgery
JP4656697B2 (en) 2000-06-16 2011-03-23 キヤノンアネルバ株式会社 High frequency sputtering equipment
US6585765B1 (en) 2000-06-29 2003-07-01 Advanced Cardiovascular Systems, Inc. Implantable device having substances impregnated therein and a method of impregnating the same
US20020077693A1 (en) 2000-12-19 2002-06-20 Barclay Bruce J. Covered, coiled drug delivery stent and method
US20030077200A1 (en) 2000-07-07 2003-04-24 Craig Charles H. Enhanced radiopaque alloy stent
US20020144757A1 (en) 2000-07-07 2002-10-10 Craig Charles Horace Stainless steel alloy with improved radiopaque characteristics
US20030018380A1 (en) * 2000-07-07 2003-01-23 Craig Charles H. Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom
US6676989B2 (en) * 2000-07-10 2004-01-13 Epion Corporation Method and system for improving the effectiveness of medical stents by the application of gas cluster ion beam technology
US6709451B1 (en) 2000-07-14 2004-03-23 Norman Noble, Inc. Channeled vascular stent apparatus and method
NZ505774A (en) 2000-07-17 2002-12-20 Ind Res Ltd Oxalate stabilised titania solutions and coating compositions and catalysts formed therefrom
AU2001277007A1 (en) 2000-07-19 2002-01-30 Regents Of The University Of Minnesota Apparatus and method for synthesizing films and coatings by focused particle beam deposition
US20050113798A1 (en) 2000-07-21 2005-05-26 Slater Charles R. Methods and apparatus for treating the interior of a blood vessel
DE10040897B4 (en) * 2000-08-18 2006-04-13 TransMIT Gesellschaft für Technologietransfer mbH Nanoscale porous fibers of polymeric materials
US6399528B1 (en) 2000-09-01 2002-06-04 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Porous aluminum oxide structures and processes for their production
US6390967B1 (en) 2000-09-14 2002-05-21 Xoft Microtube, Inc. Radiation for inhibiting hyperplasia after intravascular intervention
US6478815B1 (en) 2000-09-18 2002-11-12 Inflow Dynamics Inc. Vascular and endoluminal stents
US7402173B2 (en) 2000-09-18 2008-07-22 Boston Scientific Scimed, Inc. Metal stent with surface layer of noble metal oxide and method of fabrication
US7101391B2 (en) 2000-09-18 2006-09-05 Inflow Dynamics Inc. Primarily niobium stent
US20020062154A1 (en) 2000-09-22 2002-05-23 Ayers Reed A. Non-uniform porosity tissue implant
US6716444B1 (en) 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US6805898B1 (en) 2000-09-28 2004-10-19 Advanced Cardiovascular Systems, Inc. Surface features of an implantable medical device
US6254632B1 (en) 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment
US6953560B1 (en) 2000-09-28 2005-10-11 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US20020051730A1 (en) 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
KR200227881Y1 (en) 2000-09-29 2001-06-15 주식회사이오니아테크놀로지 Image storag system of dental diagnosis
DE60112318D1 (en) 2000-10-16 2005-09-01 Conor Medsystems Inc EXPANDABLE MEDICAL DEVICE FOR DELIVERING A REMEDY
WO2002033019A1 (en) 2000-10-16 2002-04-25 3M Innovative Properties Company Method of making ceramic aggregate particles
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6558733B1 (en) 2000-10-26 2003-05-06 Advanced Cardiovascular Systems, Inc. Method for etching a micropatterned microdepot prosthesis
US6663664B1 (en) 2000-10-26 2003-12-16 Advanced Cardiovascular Systems, Inc. Self-expanding stent with time variable radial force
US6365222B1 (en) 2000-10-27 2002-04-02 Siemens Westinghouse Power Corporation Abradable coating applied with cold spray technique
US6758859B1 (en) 2000-10-30 2004-07-06 Kenny L. Dang Increased drug-loading and reduced stress drug delivery device
US6918927B2 (en) 2000-10-31 2005-07-19 Cook Incorporated Coated implantable medical device
DE10055686A1 (en) 2000-11-03 2002-05-08 Biotronik Mess & Therapieg Device for influencing cell proliferation mechanisms in vessels of the human or animal body
US8062098B2 (en) * 2000-11-17 2011-11-22 Duescher Wayne O High speed flat lapping platen
US8372139B2 (en) 2001-02-14 2013-02-12 Advanced Bio Prosthetic Surfaces, Ltd. In vivo sensor and method of making same
US6638246B1 (en) 2000-11-28 2003-10-28 Scimed Life Systems, Inc. Medical device for delivery of a biologically active material to a lumen
US6517888B1 (en) * 2000-11-28 2003-02-11 Scimed Life Systems, Inc. Method for manufacturing a medical device having a coated portion by laser ablation
NL1016779C2 (en) 2000-12-02 2002-06-04 Cornelis Johannes Maria V Rijn Mold, method for manufacturing precision products with the aid of a mold, as well as precision products, in particular microsieves and membrane filters, manufactured with such a mold.
DE10061057A1 (en) 2000-12-08 2002-06-13 Pharmed Holding Gmbh Chip systems for the controlled emission of chemically sensitive substances
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US20040117005A1 (en) 2000-12-15 2004-06-17 Nagarada Gadde Badari Narayan Stent with drug-delivery system
DE10064596A1 (en) 2000-12-18 2002-06-20 Biotronik Mess & Therapieg Application of a marker element to an implant, especially a stent, comprises introducing a solidifiable material into a recess and solidifying the material in the recess
US7244272B2 (en) 2000-12-19 2007-07-17 Nicast Ltd. Vascular prosthesis and method for production thereof
US20040030377A1 (en) 2001-10-19 2004-02-12 Alexander Dubson Medicated polymer-coated stent assembly
ATE369817T1 (en) 2000-12-22 2007-09-15 Avantec Vascular Corp DEVICE FOR DELIVERING THERAPEUTIC ACTIVE INGREDIENTS
US7083642B2 (en) 2000-12-22 2006-08-01 Avantec Vascular Corporation Delivery of therapeutic capable agents
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US20030033007A1 (en) 2000-12-22 2003-02-13 Avantec Vascular Corporation Methods and devices for delivery of therapeutic capable agents with variable release profile
US6398806B1 (en) 2000-12-26 2002-06-04 Scimed Life Systems, Inc. Monolayer modification to gold coated stents to reduce adsorption of protein
US6913617B1 (en) 2000-12-27 2005-07-05 Advanced Cardiovascular Systems, Inc. Method for creating a textured surface on an implantable medical device
US6663662B2 (en) 2000-12-28 2003-12-16 Advanced Cardiovascular Systems, Inc. Diffusion barrier layer for implantable devices
US6635082B1 (en) 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
US6641607B1 (en) 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US20020087123A1 (en) 2001-01-02 2002-07-04 Hossainy Syed F.A. Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices
US6544582B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Method and apparatus for coating an implantable device
CA2432438C (en) 2001-01-09 2011-04-26 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US6583048B2 (en) 2001-01-17 2003-06-24 Air Products And Chemicals, Inc. Organosilicon precursors for interlayer dielectric films with low dielectric constants
US6752829B2 (en) 2001-01-30 2004-06-22 Scimed Life Systems, Inc. Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same
JP2002308683A (en) 2001-01-31 2002-10-23 Toshiba Ceramics Co Ltd Ceramic member with roughened surface and method for manufacturing the same
US6964680B2 (en) 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
US6767360B1 (en) 2001-02-08 2004-07-27 Inflow Dynamics Inc. Vascular stent with composite structure for magnetic reasonance imaging capabilities
DE10106186A1 (en) 2001-02-10 2002-08-14 Oxeno Olefinchemie Gmbh Process for the condensation of aldehydes with ketones by means of a multi-phase reaction
NZ540000A (en) 2001-02-16 2007-05-31 Abbott Lab Vascular Entpr Ltd Implants with tacrolimus
DE10107339A1 (en) 2001-02-16 2002-09-05 Jomed Gmbh Implant used for treating vascular narrowing or occlusion, especially for controlling restenosis contains FK506 in chemically bound or physically fixed form
DE10127011A1 (en) 2001-06-05 2002-12-12 Jomed Gmbh Implant used for treating vascular narrowing or occlusion, especially for controlling restenosis contains FK506 in chemically bound or physically fixed form
US6998060B2 (en) 2001-03-01 2006-02-14 Cordis Corporation Flexible stent and method of manufacture
US6679911B2 (en) 2001-03-01 2004-01-20 Cordis Corporation Flexible stent
ATE322918T1 (en) 2001-03-02 2006-04-15 Univ Laval PLASMA SURFACE GRAFTING PROCESS FOR THROMBOGENICITY REDUCTION
WO2002069848A2 (en) 2001-03-06 2002-09-12 Board Of Regents, The University Of Texas System Apparatus for stent deployment with delivery of bioactive agents
US20020133225A1 (en) 2001-03-13 2002-09-19 Gordon Lucas S. Methods and apparatuses for delivering a medical agent to a medical implant
WO2002074431A1 (en) 2001-03-21 2002-09-26 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Hollow spheres from layered precursor deposition on sacrificial colloidal core particles
US20020138136A1 (en) 2001-03-23 2002-09-26 Scimed Life Systems, Inc. Medical device having radio-opacification and barrier layers
US6709622B2 (en) 2001-03-23 2004-03-23 Romain Billiet Porous nanostructures and method of fabrication thereof
US6780424B2 (en) 2001-03-30 2004-08-24 Charles David Claude Controlled morphologies in polymer drug for release of drugs from polymer films
US6673105B1 (en) * 2001-04-02 2004-01-06 Advanced Cardiovascular Systems, Inc. Metal prosthesis coated with expandable ePTFE
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
ES2173817B1 (en) 2001-04-16 2003-10-16 Fundacion Inasmet METHOD FOR THE MANUFACTURE OF ENDO-OSEOS IMPLANTS OR MEDICAL PROTESIS THROUGH THE IONIC IMPLEMENTATION TECHNIQUE.
US7056339B2 (en) * 2001-04-20 2006-06-06 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery platform
WO2002085253A1 (en) 2001-04-20 2002-10-31 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery platform and methods for the inhibition of neointima formation
US7048939B2 (en) 2001-04-20 2006-05-23 The Board Of Trustees Of The Leland Stanford Junior University Methods for the inhibition of neointima formation
US6712845B2 (en) 2001-04-24 2004-03-30 Advanced Cardiovascular Systems, Inc. Coating for a stent and a method of forming the same
US6915964B2 (en) 2001-04-24 2005-07-12 Innovative Technology, Inc. System and process for solid-state deposition and consolidation of high velocity powder particles using thermal plastic deformation
US7232460B2 (en) 2001-04-25 2007-06-19 Xillus, Inc. Nanodevices, microdevices and sensors on in-vivo structures and method for the same
US6660034B1 (en) 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
EP1656961B1 (en) 2001-05-02 2015-08-05 InFlow Dynamics, Inc. Immuno-tolerant stent with surface microstructure
US6613083B2 (en) * 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US8182527B2 (en) * 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
WO2002089702A2 (en) * 2001-05-09 2002-11-14 Epion Corporation Method and system for improving the effectiveness of artificial joints by the application of gas cluster ion beam technology
US6656506B1 (en) 2001-05-09 2003-12-02 Advanced Cardiovascular Systems, Inc. Microparticle coated medical device
US7105199B2 (en) 2001-05-11 2006-09-12 Exogenesis Corporation Methods of adhering drugs to the surface of medical devices through ion beam surface modification
US7247338B2 (en) 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US6973718B2 (en) 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
US7862495B2 (en) 2001-05-31 2011-01-04 Advanced Cardiovascular Systems, Inc. Radiation or drug delivery source with activity gradient to minimize edge effects
US6712844B2 (en) 2001-06-06 2004-03-30 Advanced Cardiovascular Systems, Inc. MRI compatible stent
EP1399200B2 (en) 2001-06-11 2014-07-02 Boston Scientific Limited COMPOSITE ePTFE/TEXTILE PROSTHESIS
US7201940B1 (en) * 2001-06-12 2007-04-10 Advanced Cardiovascular Systems, Inc. Method and apparatus for thermal spray processing of medical devices
US6527938B2 (en) 2001-06-21 2003-03-04 Syntheon, Llc Method for microporous surface modification of implantable metallic medical articles
US6585755B2 (en) * 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US6676987B2 (en) * 2001-07-02 2004-01-13 Scimed Life Systems, Inc. Coating a medical appliance with a bubble jet printing head
KR20030003465A (en) 2001-07-02 2003-01-10 주식회사 한단정보통신 A file reproduction system using a set-top box and the file reproducing method
US20030050687A1 (en) 2001-07-03 2003-03-13 Schwade Nathan D. Biocompatible stents and method of deployment
EP1273314A1 (en) 2001-07-06 2003-01-08 Terumo Kabushiki Kaisha Stent
US6715640B2 (en) * 2001-07-09 2004-04-06 Innovative Technology, Inc. Powder fluidizing devices and portable powder-deposition apparatus for coating and spray forming
ES2266148T5 (en) 2001-07-20 2012-11-06 Sorin Biomedica Cardio S.R.L. Stent
EP1416884A4 (en) 2001-07-26 2007-03-07 Avantec Vascular Corp Delivery of therapeutic capable agents
US6979346B1 (en) 2001-08-08 2005-12-27 Advanced Cardiovascular Systems, Inc. System and method for improved stent retention
JP4151884B2 (en) 2001-08-08 2008-09-17 独立行政法人理化学研究所 Method for producing a material in which a composite metal oxide nanomaterial is formed on a solid surface
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
EP1437989A2 (en) 2001-08-27 2004-07-21 James C. Thomas, Jr. Expandable implant for partial disc replacement and reinforcement of a disc partially removed in a discectomy and for reduction and maintenance of alignment of cancellous bone fractures and methods and apparatuses for same.
US20060224234A1 (en) 2001-08-29 2006-10-05 Swaminathan Jayaraman Drug eluting structurally variable stent
GB0121980D0 (en) 2001-09-11 2001-10-31 Cathnet Science Holding As Expandable stent
US20030047505A1 (en) 2001-09-13 2003-03-13 Grimes Craig A. Tubular filter with branched nanoporous membrane integrated with a support and method of producing same
WO2003024357A2 (en) 2001-09-14 2003-03-27 Martin Francis J Microfabricated nanopore device for sustained release of therapeutic agent
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US6669980B2 (en) 2001-09-18 2003-12-30 Scimed Life Systems, Inc. Method for spray-coating medical devices
US7776379B2 (en) 2001-09-19 2010-08-17 Medlogics Device Corporation Metallic structures incorporating bioactive materials and methods for creating the same
US20030060873A1 (en) 2001-09-19 2003-03-27 Nanomedical Technologies, Inc. Metallic structures incorporating bioactive materials and methods for creating the same
CA2458828A1 (en) 2001-09-24 2003-05-01 James J. Barry Optimized dosing for drug coated stents
US6827737B2 (en) 2001-09-25 2004-12-07 Scimed Life Systems, Inc. EPTFE covering for endovascular prostheses and method of manufacture
US7195640B2 (en) 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US6753071B1 (en) 2001-09-27 2004-06-22 Advanced Cardiovascular Systems, Inc. Rate-reducing membrane for release of an agent
WO2003028660A2 (en) 2001-10-04 2003-04-10 Case Western Reserve University Drug delivery devices and methods
DE10150995A1 (en) 2001-10-08 2003-04-10 Biotronik Mess & Therapieg Implant e.g. a stent, comprises a decomposable substance which allows contact between the cell proliferation inhibitor and the stent surroundings only after a specified time
US6709397B2 (en) 2001-10-16 2004-03-23 Envisioneering, L.L.C. Scanning probe
WO2003055414A1 (en) 2001-10-18 2003-07-10 Advanced Stent Technologies, Inc. Stent for vessel support, coverage and side branch accessibility
US8562664B2 (en) 2001-10-25 2013-10-22 Advanced Cardiovascular Systems, Inc. Manufacture of fine-grained material for use in medical devices
DE10152055A1 (en) 2001-10-25 2003-05-08 Nttf Gmbh Mechanically and thermodynamically stable amorphous carbon layers for temperature-sensitive surfaces
US6887578B2 (en) 2001-10-30 2005-05-03 Massachusetts Institute Of Technology Fluorocarbon-organosilicon copolymers and coatings prepared by hot-filament chemical vapor deposition
US20030083614A1 (en) 2001-10-30 2003-05-01 Boehringer Ingelheim Pharma Kg Controlled release endoprosthetic device
EP1308179A1 (en) 2001-10-30 2003-05-07 Boehringer Ingelheim Pharma GmbH & Co.KG Improved endoprosthetic device
US20030088307A1 (en) 2001-11-05 2003-05-08 Shulze John E. Potent coatings for stents
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US6764709B2 (en) 2001-11-08 2004-07-20 Scimed Life Systems, Inc. Method for making and measuring a coating on the surface of a medical device using an ultraviolet laser
US6807440B2 (en) 2001-11-09 2004-10-19 Scimed Life Systems, Inc. Ceramic reinforcement members for MRI devices
EP1310242A1 (en) 2001-11-13 2003-05-14 SORIN BIOMEDICA CARDIO S.p.A. Carrier and kit for endoluminal delivery of active principles
CN1301757C (en) 2001-11-27 2007-02-28 多喜兰株式会社 Implant material and process for producing the same
US20030104028A1 (en) 2001-11-29 2003-06-05 Hossainy Syed F.A. Rate limiting barriers for implantable devices and methods for fabrication thereof
US6465052B1 (en) 2001-11-30 2002-10-15 Nanotek Instruments, Inc. Method for production of nano-porous coatings
US7014654B2 (en) 2001-11-30 2006-03-21 Scimed Life Systems, Inc. Stent designed for the delivery of therapeutic substance or other agents
DE60106962T2 (en) 2001-12-12 2005-04-28 Hehrlein, Christoph, Dr. Porous metallic stent with a coating
US6752826B2 (en) 2001-12-14 2004-06-22 Thoratec Corporation Layered stent-graft and methods of making the same
US6866805B2 (en) 2001-12-27 2005-03-15 Advanced Cardiovascular Systems, Inc. Hybrid intravascular stent
US7575759B2 (en) 2002-01-02 2009-08-18 The Regents Of The University Of Michigan Tissue engineering scaffolds
DE10200387B4 (en) 2002-01-08 2009-11-26 Translumina Gmbh stent
US6506972B1 (en) * 2002-01-22 2003-01-14 Nanoset, Llc Magnetically shielded conductor
US6949590B2 (en) 2002-01-10 2005-09-27 University Of Washington Hydrogels formed by non-covalent linkages
MXPA04006731A (en) * 2002-01-10 2004-10-04 Novartis Ag Drug delivery systems for the prevention and treatment of vascular diseases comprising rapamycin and derivatives thereof.
US6906256B1 (en) 2002-01-22 2005-06-14 Nanoset, Llc Nanomagnetic shielding assembly
US6864418B2 (en) 2002-12-18 2005-03-08 Nanoset, Llc Nanomagnetically shielded substrate
WO2003061755A2 (en) 2002-01-22 2003-07-31 Nanoset, Llc Nanomagnetically shielded substrate
US7060089B2 (en) 2002-01-23 2006-06-13 Boston Scientific Scimed, Inc. Multi-layer stent
US7371582B2 (en) 2002-01-23 2008-05-13 Boditechmed Inc. Lateral flow quantitative assay method and strip and laser-induced fluorescence detection device therefor
US8685427B2 (en) 2002-07-31 2014-04-01 Boston Scientific Scimed, Inc. Controlled drug delivery
US20030153901A1 (en) 2002-02-08 2003-08-14 Atrium Medical Corporation Drug delivery panel
US20040029706A1 (en) 2002-02-14 2004-02-12 Barrera Enrique V. Fabrication of reinforced composite material comprising carbon nanotubes, fullerenes, and vapor-grown carbon fibers for thermal barrier materials, structural ceramics, and multifunctional nanocomposite ceramics
US20030153971A1 (en) 2002-02-14 2003-08-14 Chandru Chandrasekaran Metal reinforced biodegradable intraluminal stents
ATE478696T1 (en) * 2002-02-15 2010-09-15 Gilead Palo Alto Inc POLYMER COATING FOR MEDICAL DEVICES
AU2003217835A1 (en) 2002-02-27 2003-09-09 University Of Virginia Patent Foundation Methods for making implantable medical devices having microstructures
US20030170605A1 (en) 2002-03-11 2003-09-11 Egan Visual Inc. Vapor deposited writing surfaces
US6743463B2 (en) 2002-03-28 2004-06-01 Scimed Life Systems, Inc. Method for spray-coating a medical device having a tubular wall such as a stent
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
EP1348402A1 (en) 2002-03-29 2003-10-01 Advanced Laser Applications Holding S.A. Intraluminal endoprosthesis, radially expandable, perforated for drug delivery
US7691461B1 (en) 2002-04-01 2010-04-06 Advanced Cardiovascular Systems, Inc. Hybrid stent and method of making
US20030211135A1 (en) 2002-04-11 2003-11-13 Greenhalgh Skott E. Stent having electrospun covering and method
JP3714471B2 (en) 2002-04-24 2005-11-09 学校法人慶應義塾 Medical covering material
US20030204168A1 (en) 2002-04-30 2003-10-30 Gjalt Bosma Coated vascular devices
US7008979B2 (en) 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
WO2003092791A2 (en) 2002-05-02 2003-11-13 Scimed Life Systems, Inc. Energetically-controlled delivery of biologically active material from an implanted medical device
US7122048B2 (en) 2002-05-03 2006-10-17 Scimed Life Systems, Inc. Hypotube endoluminal device
GB0210786D0 (en) 2002-05-10 2002-06-19 Plasma Coatings Ltd Orthopaedic and dental implants
DE60303705T2 (en) 2002-05-14 2006-10-19 Terumo K.K. Coated stent for the release of active substances
JP2005525911A (en) 2002-05-20 2005-09-02 オーバス メディカル テクノロジーズ インク. Implantable drug eluting medical device
US20040000540A1 (en) * 2002-05-23 2004-01-01 Soboyejo Winston O. Laser texturing of surfaces for biomedical implants
US7048767B2 (en) 2002-06-11 2006-05-23 Spire Corporation Nano-crystalline, homo-metallic, protective coatings
US8211455B2 (en) 2002-06-19 2012-07-03 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US20040002755A1 (en) * 2002-06-28 2004-01-01 Fischell David R. Method and apparatus for treating vulnerable coronary plaques using drug-eluting stents
US7314484B2 (en) 2002-07-02 2008-01-01 The Foundry, Inc. Methods and devices for treating aneurysms
US20040133270A1 (en) 2002-07-08 2004-07-08 Axel Grandt Drug eluting stent and methods of manufacture
US7159163B2 (en) 2002-07-08 2007-01-02 Qualcomm Incorporated Feedback for data transmissions
US8337893B2 (en) 2002-07-10 2012-12-25 Florida Research Foundation, Inc, University Of Sol-gel derived bioactive glass polymer composite
US20050096731A1 (en) 2002-07-11 2005-05-05 Kareen Looi Cell seeded expandable body
AU2003249017A1 (en) 2002-07-11 2004-02-02 Setagon, Inc. Methods and apparatuses for repairing aneurysms
WO2004006983A2 (en) 2002-07-11 2004-01-22 University Of Virginia Patent Foundation Expandable body having deployable microstructures and related methods
ATE495769T1 (en) 2002-07-12 2011-02-15 Cook Inc COATED MEDICAL DEVICE
DE50202547D1 (en) * 2002-07-24 2005-04-28 Zimmer Gmbh Winterthur Method of making an implant and method of decontaminating a jet particle treated surface
EP1539041A1 (en) 2002-07-25 2005-06-15 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
US6974805B2 (en) 2002-08-01 2005-12-13 Min Hu Configuration of glycosaminoglycans
US7745532B2 (en) 2002-08-02 2010-06-29 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US7255710B2 (en) 2002-08-06 2007-08-14 Icon Medical Corp. Helical stent with micro-latches
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
US7029495B2 (en) 2002-08-28 2006-04-18 Scimed Life Systems, Inc. Medical devices and methods of making the same
AU2003270070A1 (en) 2002-09-04 2004-03-29 Reva Medical, Inc. A slide and lock stent and method of manufacture from a single piece shape
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
EP1402849B2 (en) 2002-09-20 2011-03-16 Abbott Laboratories Vascular Enterprises Limited Stent with rough surface and its manufacturing method
US7001422B2 (en) 2002-09-23 2006-02-21 Cordis Neurovascular, Inc Expandable stent and delivery system
US7261752B2 (en) 2002-09-24 2007-08-28 Chien-Min Sung Molten braze-coated superabrasive particles and associated methods
US6830598B1 (en) 2002-09-24 2004-12-14 Chien-Min Sung Molten braze coated superabrasive particles and associated methods
US6915796B2 (en) 2002-09-24 2005-07-12 Chien-Min Sung Superabrasive wire saw and associated methods of manufacture
US7060051B2 (en) 2002-09-24 2006-06-13 Scimed Life Systems, Inc. Multi-balloon catheter with hydrogel coating
US20040059409A1 (en) 2002-09-24 2004-03-25 Stenzel Eric B. Method of applying coatings to a medical device
AU2003272710B2 (en) 2002-09-26 2008-05-15 Vactronix Scientific, Llc Implantable materials having engineered surfaces and method of making same
JP2006500996A (en) 2002-09-26 2006-01-12 エンドバスキュラー デバイセス インコーポレイテッド Apparatus and method for delivering mitomycin via an eluting biocompatible implantable medical device
US6971813B2 (en) 2002-09-27 2005-12-06 Labcoat, Ltd. Contact coating of prostheses
US7794494B2 (en) 2002-10-11 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices
US7976936B2 (en) 2002-10-11 2011-07-12 University Of Connecticut Endoprostheses
EP2260882B1 (en) * 2002-10-11 2020-03-04 Boston Scientific Limited Implantable medical devices
EP1553896B1 (en) 2002-10-22 2009-09-09 Medtronic Vascular, Inc. Stent with eccentric coating
US20040088038A1 (en) 2002-10-30 2004-05-06 Houdin Dehnad Porous metal for drug-loaded stents
SE0203224D0 (en) 2002-10-31 2002-10-31 Cerbio Tech Ab Method of making structured ceramic coatings and coated devices prepared with the method
US20040086674A1 (en) 2002-11-01 2004-05-06 Holman Thomas J. Laser sintering process and devices made therefrom
US8221495B2 (en) 2002-11-07 2012-07-17 Abbott Laboratories Integration of therapeutic agent into a bioerodible medical device
WO2004043298A1 (en) 2002-11-07 2004-05-27 Abbott Laboratories Prosthesis having varied concentration of beneficial agent
CA2513721C (en) 2002-11-08 2013-04-16 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US20040142014A1 (en) 2002-11-08 2004-07-22 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US20040143321A1 (en) 2002-11-08 2004-07-22 Conor Medsystems, Inc. Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
JP2006514848A (en) 2002-11-13 2006-05-18 セタゴン インコーポレーティッド Medical device having porous layer and method for producing the same
US9770349B2 (en) 2002-11-13 2017-09-26 University Of Virginia Patent Foundation Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
US20050070989A1 (en) 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
US8449601B2 (en) 2002-11-19 2013-05-28 Boston Scientific Scimed, Inc. Medical devices
US6923829B2 (en) 2002-11-25 2005-08-02 Advanced Bio Prosthetic Surfaces, Ltd. Implantable expandable medical devices having regions of differential mechanical properties and methods of making same
JP4119230B2 (en) 2002-11-26 2008-07-16 株式会社 日立ディスプレイズ Display device
US7491234B2 (en) 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
JP2004188314A (en) 2002-12-11 2004-07-08 Kawasaki Heavy Ind Ltd Composite substrate having hydrophilic surface
US7371256B2 (en) 2002-12-16 2008-05-13 Poly-Med, Inc Composite vascular constructs with selectively controlled properties
US7666216B2 (en) 2002-12-24 2010-02-23 Novostent Corporation Delivery catheter for ribbon-type prosthesis and methods of use
US7846198B2 (en) 2002-12-24 2010-12-07 Novostent Corporation Vascular prosthesis and methods of use
US20050165469A1 (en) 2002-12-24 2005-07-28 Michael Hogendijk Vascular prosthesis including torsional stabilizer and methods of use
US6725901B1 (en) 2002-12-27 2004-04-27 Advanced Cardiovascular Systems, Inc. Methods of manufacture of fully consolidated or porous medical devices
US6803070B2 (en) 2002-12-30 2004-10-12 Scimed Life Systems, Inc. Apparatus and method for embedding nanoparticles in polymeric medical devices
US6896697B1 (en) 2002-12-30 2005-05-24 Advanced Cardiovascular Systems, Inc. Intravascular stent
CA2511486A1 (en) 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
US7105018B1 (en) 2002-12-30 2006-09-12 Advanced Cardiovascular Systems, Inc. Drug-eluting stent cover and method of use
US20040236415A1 (en) 2003-01-02 2004-11-25 Richard Thomas Medical devices having drug releasing polymer reservoirs
US7169177B2 (en) * 2003-01-15 2007-01-30 Boston Scientific Scimed, Inc. Bifurcated stent
US20040143317A1 (en) 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices
KR100495875B1 (en) 2003-01-18 2005-06-16 사회복지법인 삼성생명공익재단 Stent for percutaneous coronary intervention coated with drugs for the prevention of vascular restenosis
GB2397233A (en) 2003-01-20 2004-07-21 Julie Gold Biomedical device with bioerodable coating
US6852122B2 (en) 2003-01-23 2005-02-08 Cordis Corporation Coated endovascular AAA device
US6918929B2 (en) 2003-01-24 2005-07-19 Medtronic Vascular, Inc. Drug-polymer coated stent with pegylated styrenic block copolymers
WO2004069169A2 (en) 2003-01-31 2004-08-19 Scimed Life Systems, Inc. Localized drug delivery using drug-loaded nanocapsules and implantable device coated with the same
US7311727B2 (en) 2003-02-05 2007-12-25 Board Of Trustees Of The University Of Arkansas Encased stent
US20080038146A1 (en) 2003-02-10 2008-02-14 Jurgen Wachter Metal alloy for medical devices and implants
FR2851181B1 (en) 2003-02-17 2006-05-26 Commissariat Energie Atomique METHOD FOR COATING A SURFACE
EP1596895B1 (en) 2003-02-18 2009-02-04 Medtronic, Inc. Occlusion resistant hydrocephalic shunt
US20050079199A1 (en) 2003-02-18 2005-04-14 Medtronic, Inc. Porous coatings for drug release from medical devices
US20040167572A1 (en) 2003-02-20 2004-08-26 Roth Noah M. Coated medical devices
EP1449546B1 (en) 2003-02-21 2010-10-27 Sorin Biomedica Cardio S.R.L. A process for producing stents and corresponding stent
US7001421B2 (en) 2003-02-28 2006-02-21 Medtronic Vascular, Inc. Stent with phenoxy primer coating
US6699282B1 (en) 2003-03-06 2004-03-02 Gelsus Research And Consulting, Inc. Method and apparatus for delivery of medication
US6932930B2 (en) 2003-03-10 2005-08-23 Synecor, Llc Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
US8281737B2 (en) * 2003-03-10 2012-10-09 Boston Scientific Scimed, Inc. Coated medical device and method for manufacturing the same
US20040202692A1 (en) 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device and method for in situ selective modulation of agent delivery
US7163555B2 (en) 2003-04-08 2007-01-16 Medtronic Vascular, Inc. Drug-eluting stent for controlled drug delivery
US20050107870A1 (en) 2003-04-08 2005-05-19 Xingwu Wang Medical device with multiple coating layers
US20050216075A1 (en) 2003-04-08 2005-09-29 Xingwu Wang Materials and devices of enhanced electromagnetic transparency
US20050070996A1 (en) 2003-04-08 2005-03-31 Dinh Thomas Q. Drug-eluting stent for controlled drug delivery
US20060142853A1 (en) 2003-04-08 2006-06-29 Xingwu Wang Coated substrate assembly
KR20060010736A (en) 2003-04-14 2006-02-02 가오가부시끼가이샤 Cleaning agent composition
US20050038498A1 (en) 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20050221072A1 (en) 2003-04-17 2005-10-06 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20040215313A1 (en) 2003-04-22 2004-10-28 Peiwen Cheng Stent with sandwich type coating
US20040236399A1 (en) 2003-04-22 2004-11-25 Medtronic Vascular, Inc. Stent with improved surface adhesion
US20040230176A1 (en) 2003-04-23 2004-11-18 Medtronic Vascular, Inc. System for treating a vascular condition that inhibits restenosis at stent ends
US7482034B2 (en) * 2003-04-24 2009-01-27 Boston Scientific Scimed, Inc. Expandable mask stent coating method
WO2004096176A2 (en) 2003-04-25 2004-11-11 Boston Scientific Scimed Inc. Solid drug formulation and device for storage and controlled delivery thereof
US7288084B2 (en) 2003-04-28 2007-10-30 Boston Scientific Scimed, Inc. Drug-loaded medical device
EP1633320A2 (en) * 2003-05-02 2006-03-15 SurModics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US7279174B2 (en) 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
US20040230290A1 (en) 2003-05-15 2004-11-18 Jan Weber Medical devices and methods of making the same
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
BRPI0410641A (en) * 2003-05-16 2006-07-04 Blue Membranes Gmbh substrate coating process with carbon based material
US7524527B2 (en) 2003-05-19 2009-04-28 Boston Scientific Scimed, Inc. Electrostatic coating of a device
US20040236416A1 (en) 2003-05-20 2004-11-25 Robert Falotico Increased biocompatibility of implantable medical devices
US20050211680A1 (en) 2003-05-23 2005-09-29 Mingwei Li Systems and methods for laser texturing of surfaces of a substrate
US7297644B2 (en) 2003-05-28 2007-11-20 Air Products Polymers, L.P. Nonwoven binders with high wet/dry tensile strength ratio
US20030216803A1 (en) 2003-05-28 2003-11-20 Ledergerber Walter J. Textured and drug eluting stent-grafts
MXPA05011231A (en) 2003-05-28 2006-09-14 Soheil Asgari Implants comprising functionalized carbon surfaces
US7041127B2 (en) 2003-05-28 2006-05-09 Ledergerber Walter J Textured and drug eluting coronary artery stent
US7270679B2 (en) 2003-05-30 2007-09-18 Warsaw Orthopedic, Inc. Implants based on engineered metal matrix composite materials having enhanced imaging and wear resistance
US6904658B2 (en) 2003-06-02 2005-06-14 Electroformed Stents, Inc. Process for forming a porous drug delivery layer
US6979348B2 (en) 2003-06-04 2005-12-27 Medtronic Vascular, Inc. Reflowed drug-polymer coated stent and method thereof
JP4971580B2 (en) 2003-06-05 2012-07-11 テルモ株式会社 Stent and method for manufacturing stent
US7169179B2 (en) 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
TWI255580B (en) 2003-07-02 2006-05-21 Sony Corp MEMS type oscillator, process for fabricating the same, filter, and communication unit
EP1647020A1 (en) 2003-07-10 2006-04-19 Koninklijke Philips Electronics N.V. Embedding watermark for protecting multiple copies of a signal
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
US20050021128A1 (en) * 2003-07-24 2005-01-27 Medtronic Vascular, Inc. Compliant, porous, rolled stent
US7682603B2 (en) * 2003-07-25 2010-03-23 The Trustees Of The University Of Pennsylvania Polymersomes incorporating highly emissive probes
US20050027350A1 (en) 2003-07-30 2005-02-03 Biotronik Mess-Und Therapiegeraete Gmbh & Co Ingenieurbuero Berlin Endovascular implant for the injection of an active substance into the media of a blood vessel
US7056591B1 (en) 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US20050033417A1 (en) 2003-07-31 2005-02-10 John Borges Coating for controlled release of a therapeutic agent
JPWO2005011796A1 (en) 2003-08-05 2006-09-14 株式会社カネカ Indwelling stent
US20050037047A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US20050055085A1 (en) 2003-09-04 2005-03-10 Rivron Nicolas C. Implantable medical devices having recesses
US20050055080A1 (en) 2003-09-05 2005-03-10 Naim Istephanous Modulated stents and methods of making the stents
US7494950B2 (en) 2003-09-05 2009-02-24 Synthes (U.S.A.) Bone cement compositions having fiber-reinforcement and/or increased flowability
US7488343B2 (en) 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
US20050060020A1 (en) 2003-09-17 2005-03-17 Scimed Life Systems, Inc. Covered stent with biologically active material
EP1677714A4 (en) 2003-09-18 2008-01-16 Advanced Bio Prothestic Surfac Medical device having mems functionality and methods of making same
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050070990A1 (en) 2003-09-26 2005-03-31 Stinson Jonathan S. Medical devices and methods of making same
US7055237B2 (en) 2003-09-29 2006-06-06 Medtronic Vascular, Inc. Method of forming a drug eluting stent
US7247166B2 (en) 2003-09-29 2007-07-24 Advanced Cardiovascular Systems, Inc. Intravascular stent with extendible end rings
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US7618647B2 (en) 2003-10-03 2009-11-17 Boston Scientific Scimed, Inc. Using bucky paper as a therapeutic aid in medical applications
US7284677B2 (en) 2003-10-08 2007-10-23 Elizabeth Ann Guevara Bottle holding appliance and method for its use
WO2005039668A2 (en) 2003-10-21 2005-05-06 Boiarski Anthony A Implantable drug delivery device for sustained release of therapeutic agent
US20050087520A1 (en) 2003-10-28 2005-04-28 Lixiao Wang Method and apparatus for selective ablation of coatings from medical devices
FR2861740B1 (en) 2003-10-29 2005-12-16 Inst Rech Developpement Ird ATTENUATED VIRULENCE PROTOZOATIC STRAINS AND THEIR USE
US20050113936A1 (en) * 2003-10-30 2005-05-26 Brustad John R. Surface treatments and modifications using nanostructure materials
US7208172B2 (en) 2003-11-03 2007-04-24 Medlogics Device Corporation Metallic composite coating for delivery of therapeutic agents from the surface of implantable devices
GB0325647D0 (en) 2003-11-03 2003-12-10 Finsbury Dev Ltd Prosthetic implant
US7435256B2 (en) 2003-11-06 2008-10-14 Boston Scientific Scimed, Inc. Method and apparatus for controlled delivery of active substance
WO2005044361A1 (en) 2003-11-07 2005-05-19 Merlin Md Pte Ltd Implantable medical devices with enhanced visibility, mechanical properties and biocompatibility
US20050100577A1 (en) 2003-11-10 2005-05-12 Parker Theodore L. Expandable medical device with beneficial agent matrix formed by a multi solvent system
WO2005044142A2 (en) 2003-11-10 2005-05-19 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
CA2545815A1 (en) 2003-11-14 2005-06-09 Genvec, Inc. Adenoviral vectored tnf-a and chemoradiation to treat cancer
US8435285B2 (en) 2003-11-25 2013-05-07 Boston Scientific Scimed, Inc. Composite stent with inner and outer stent elements and method of using the same
US20060085062A1 (en) 2003-11-28 2006-04-20 Medlogics Device Corporation Implantable stent with endothelialization factor
JP4610885B2 (en) 2003-11-28 2011-01-12 ゼオンメディカル株式会社 Cell growth suppression film and medical device
WO2005051450A1 (en) 2003-11-28 2005-06-09 Zeon Medical, Inc. Cell growth-inhibiting film, medical instrument and stent for digestive organs
JP4512351B2 (en) 2003-11-28 2010-07-28 ゼオンメディカル株式会社 Gastrointestinal stent
US20050119723A1 (en) 2003-11-28 2005-06-02 Medlogics Device Corporation Medical device with porous surface containing bioerodable bioactive composites and related methods
US20050131522A1 (en) 2003-12-10 2005-06-16 Stinson Jonathan S. Medical devices and methods of making the same
DE10358502B3 (en) 2003-12-13 2005-04-07 Daimlerchrysler Ag Production of a hollow profile used as a branched part for pipes comprises stamping a secondary molding element to connect to a further component in a pre-curved region before winding
US8017178B2 (en) 2003-12-16 2011-09-13 Cardiac Pacemakers, Inc. Coatings for implantable electrodes
US20050137677A1 (en) 2003-12-17 2005-06-23 Rush Scott L. Endovascular graft with differentiable porosity along its length
WO2005063318A1 (en) 2003-12-17 2005-07-14 Pfizer Products Inc. Stent with therapeutically active drug coated thereon
US20050137679A1 (en) 2003-12-17 2005-06-23 Pfizer Inc Modified stent useful for delivery of drugs along stent strut
US8652502B2 (en) 2003-12-19 2014-02-18 Cordis Corporation Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury
US8043311B2 (en) 2003-12-22 2011-10-25 Boston Scientific Scimed, Inc. Medical device systems
US7563324B1 (en) 2003-12-29 2009-07-21 Advanced Cardiovascular Systems Inc. System and method for coating an implantable medical device
US20050159805A1 (en) 2004-01-20 2005-07-21 Jan Weber Functional coatings and designs for medical implants
WO2005070338A1 (en) 2004-01-20 2005-08-04 Cook Incorporated Multiple stitches for attaching stent to graft
US7854756B2 (en) 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
US7211108B2 (en) 2004-01-23 2007-05-01 Icon Medical Corp. Vascular grafts with amphiphilic block copolymer coatings
US7393589B2 (en) 2004-01-30 2008-07-01 Ionbond, Inc. Dual layer diffusion bonded chemical vapor coating for medical implants
ITTO20040056A1 (en) 2004-02-05 2004-05-05 Sorin Biomedica Cardio Spa STENT FOR THE ENDOLIMINAL DELIVERY OF PRINCIPLES OR ACTIVE AGENTS
US7442681B2 (en) 2004-02-10 2008-10-28 University Of Virginia Patent Foundation Method of inhibiting vascular permeability
US20050180919A1 (en) 2004-02-12 2005-08-18 Eugene Tedeschi Stent with radiopaque and encapsulant coatings
US8049137B2 (en) 2004-02-13 2011-11-01 Boston Scientific Scimed, Inc. Laser shock peening of medical devices
US7981441B2 (en) 2004-02-18 2011-07-19 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery systems using mesoporous oxide films
US8097269B2 (en) 2004-02-18 2012-01-17 Celonova Biosciences, Inc. Bioactive material delivery systems comprising sol-gel compositions
US20050187608A1 (en) 2004-02-24 2005-08-25 O'hara Michael D. Radioprotective compound coating for medical devices
US8137397B2 (en) 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US8591568B2 (en) 2004-03-02 2013-11-26 Boston Scientific Scimed, Inc. Medical devices including metallic films and methods for making same
US20050197687A1 (en) 2004-03-02 2005-09-08 Masoud Molaei Medical devices including metallic films and methods for making same
FR2867059B1 (en) 2004-03-03 2006-05-26 Braun Medical ENDOPROTHESIS WITH MARKERS FOR CONDUCTING A LIVING BODY
US20050196518A1 (en) 2004-03-03 2005-09-08 Stenzel Eric B. Method and system for making a coated medical device
US20050203606A1 (en) 2004-03-09 2005-09-15 Vancamp Daniel H. Stent system for preventing restenosis
JP5150895B2 (en) * 2004-03-12 2013-02-27 国立大学法人長岡技術科学大学 Membrane electrode assembly, method for producing membrane electrode assembly, and polymer electrolyte fuel cell
US6979473B2 (en) 2004-03-15 2005-12-27 Boston Scientific Scimed, Inc. Method for fine bore orifice spray coating of medical devices and pre-filming atomization
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
JP2007195883A (en) 2006-01-30 2007-08-09 Toyo Advanced Technologies Co Ltd Stent and its production method
KR20070116191A (en) 2004-03-30 2007-12-06 토요 어드밴스드 테크놀로지스 컴퍼니 리미티드 Method for treating surface of material, medical material, and medical instrument
US20050220853A1 (en) 2004-04-02 2005-10-06 Kinh-Luan Dao Controlled delivery of therapeutic agents from medical articles
CN1964748A (en) 2004-04-06 2007-05-16 苏莫迪克斯公司 Coating compositions for bioactive agents
US7635515B1 (en) 2004-04-08 2009-12-22 Powdermet, Inc Heterogeneous composite bodies with isolated lenticular shaped cermet regions
US20050228477A1 (en) 2004-04-09 2005-10-13 Xtent, Inc. Topographic coatings and coating methods for medical devices
US20050228491A1 (en) 2004-04-12 2005-10-13 Snyder Alan J Anti-adhesive surface treatments
US20050230039A1 (en) 2004-04-19 2005-10-20 Michael Austin Stent with protective pads or bulges
US20050251245A1 (en) 2004-05-05 2005-11-10 Karl Sieradzki Methods and apparatus with porous materials
US7955371B2 (en) 2004-05-12 2011-06-07 Medtronic Vascular, Inc. System and method for stent deployment and infusion of a therapeutic agent into tissue adjacent to the stent ends
US7758892B1 (en) 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060100696A1 (en) 2004-11-10 2006-05-11 Atanasoska Ljiljana L Medical devices and methods of making the same
US20050266039A1 (en) 2004-05-27 2005-12-01 Jan Weber Coated medical device and method for making the same
US20050266040A1 (en) 2004-05-28 2005-12-01 Brent Gerberding Medical devices composed of porous metallic materials for delivering biologically active materials
US7695775B2 (en) * 2004-06-04 2010-04-13 Applied Microstructures, Inc. Controlled vapor deposition of biocompatible coatings over surface-treated substrates
KR20050117361A (en) 2004-06-10 2005-12-14 류용선 Titanium oxide coating stent and manufaturing method thereof
US7332101B2 (en) 2004-06-25 2008-02-19 Massachusetts Institute Of Technology Permanently linked, rigid, magnetic chains
US7078108B2 (en) 2004-07-14 2006-07-18 The Regents Of The University Of California Preparation of high-strength nanometer scale twinned coating and foil
US20060015361A1 (en) * 2004-07-16 2006-01-19 Jurgen Sattler Method and system for customer contact reporting
US7144840B2 (en) 2004-07-22 2006-12-05 Hong Kong University Of Science And Technology TiO2 material and the coating methods thereof
US7269700B2 (en) * 2004-07-26 2007-09-11 Integrated Device Technology, Inc. Status bus accessing only available quadrants during loop mode operation in a multi-queue first-in first-out memory system
CA2474367A1 (en) 2004-07-26 2006-01-26 Jingzeng Zhang Electrolytic jet plasma process and apparatus for cleaning, case hardening, coating and anodizing
US20060025848A1 (en) 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US20060034884A1 (en) 2004-08-10 2006-02-16 Stenzel Eric B Coated medical device having an increased coating surface area
EP1786363B1 (en) 2004-08-13 2010-04-14 Setagon, Inc. Methods for making medical devices having nanoporous layers
US20060275554A1 (en) 2004-08-23 2006-12-07 Zhibo Zhao High performance kinetic spray nozzle
US7507433B2 (en) 2004-09-03 2009-03-24 Boston Scientific Scimed, Inc. Method of coating a medical device using an electrowetting process
DE102004043232A1 (en) 2004-09-07 2006-03-09 Biotronik Vi Patent Ag Endoprosthesis made of magnesium alloy
DE102004043231A1 (en) 2004-09-07 2006-03-09 Biotronik Vi Patent Ag Endoprosthesis made of magnesium alloy
US7229471B2 (en) 2004-09-10 2007-06-12 Advanced Cardiovascular Systems, Inc. Compositions containing fast-leaching plasticizers for improved performance of medical devices
DE102004044738A1 (en) 2004-09-15 2006-03-16 Technische Universität München Process for producing a structuring of metal surfaces and components produced by this process
US7901451B2 (en) 2004-09-24 2011-03-08 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20060075044A1 (en) 2004-09-30 2006-04-06 Fox Kevin D System and method for electronic contact list-based search and display
US20060075092A1 (en) 2004-10-06 2006-04-06 Kabushiki Kaisha Toshiba System and method for determining the status of users and devices from access log information
US7344560B2 (en) 2004-10-08 2008-03-18 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20060079863A1 (en) 2004-10-08 2006-04-13 Scimed Life Systems, Inc. Medical devices coated with diamond-like carbon
US20060085065A1 (en) 2004-10-15 2006-04-20 Krause Arthur A Stent with auxiliary treatment structure
US20060085058A1 (en) 2004-10-20 2006-04-20 Rosenthal Arthur L System and method for delivering a biologically active material to a body lumen
US20060088566A1 (en) 2004-10-27 2006-04-27 Scimed Life Systems, Inc.,A Corporation Method of controlling drug release from a coated medical device through the use of nucleating agents
US7862835B2 (en) 2004-10-27 2011-01-04 Boston Scientific Scimed, Inc. Method of manufacturing a medical device having a porous coating thereon
CA2583911A1 (en) 2004-10-28 2006-05-11 Microchips, Inc. Orthopedic and dental implant devices providing controlled drug delivery
US20060093643A1 (en) 2004-11-04 2006-05-04 Stenzel Eric B Medical device for delivering therapeutic agents over different time periods
US7628807B2 (en) 2004-11-04 2009-12-08 Boston Scientific Scimed, Inc. Stent for delivering a therapeutic agent having increased body tissue contact surface
US20060122694A1 (en) 2004-12-03 2006-06-08 Stinson Jonathan S Medical devices and methods of making the same
GB0426841D0 (en) 2004-12-07 2005-01-12 Univ Brunel Medical implant
US20060127443A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20060129215A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060127442A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles
US20060125144A1 (en) 2004-12-14 2006-06-15 Jan Weber Stent and stent manufacturing methods
US20060129225A1 (en) 2004-12-15 2006-06-15 Kopia Gregory A Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium
US7632307B2 (en) 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
DE102004062394B4 (en) * 2004-12-23 2008-05-29 Siemens Ag Intravenous pacemaker electrode and process for its preparation
ES2693248T3 (en) 2004-12-24 2018-12-10 Hexacath Mechanical part with improved deformability
US20060140867A1 (en) 2004-12-28 2006-06-29 Helfer Jeffrey L Coated stent assembly and coating materials
US7727273B2 (en) 2005-01-13 2010-06-01 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US20090177282A1 (en) 2005-01-14 2009-07-09 National Research Council Of Canada Implantable biomimetic prosthetic bone
US8057543B2 (en) 2005-01-28 2011-11-15 Greatbatch Ltd. Stent coating for eluting medication
US8535702B2 (en) 2005-02-01 2013-09-17 Boston Scientific Scimed, Inc. Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
WO2006082221A1 (en) 2005-02-03 2006-08-10 Cinvention Ag Drug delivery materials made by sol/gel technology
US20070003589A1 (en) * 2005-02-17 2007-01-04 Irina Astafieva Coatings for implantable medical devices containing attractants for endothelial cells
DE102005010100A1 (en) 2005-03-02 2006-09-14 Hehrlein, Friedrich Wilhelm, Prof. Dr. Dr. Medical instrument with an asymmetrical microcrater in outer surface and a medicament holding fatty acid layer useful in administration of slow release drugs, e.g. in angioplasty, where medicament fatty acid layer can be mxied with acetone
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US20060200229A1 (en) 2005-03-03 2006-09-07 Robert Burgermeister Geometry and material for use in high strength, high flexibility, controlled recoil drug eluting stents
US20060199876A1 (en) 2005-03-04 2006-09-07 The University Of British Columbia Bioceramic composite coatings and process for making same
US7837726B2 (en) 2005-03-14 2010-11-23 Abbott Laboratories Visible endoprosthesis
US20060229715A1 (en) 2005-03-29 2006-10-12 Sdgi Holdings, Inc. Implants incorporating nanotubes and methods for producing the same
US9125968B2 (en) 2005-03-30 2015-09-08 Boston Scientific Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
CA2603332C (en) 2005-03-31 2013-09-10 Conor Medsystems, Inc. System and method for loading a beneficial agent into a medical device
US7641983B2 (en) 2005-04-04 2010-01-05 Boston Scientific Scimed, Inc. Medical devices including composites
CN105030390A (en) 2005-04-05 2015-11-11 万能医药公司 Degradable implantable medical devices
US20060233941A1 (en) 2005-04-15 2006-10-19 Boston Scientific Scimed, Inc. Method of coating a medical device utilizing an ion-based thin film deposition technique, a system for coating a medical device, and a medical device produced by the method
US8734851B2 (en) 2005-04-29 2014-05-27 Wisconsin Alumni Research Foundation Localized delivery of nucleic acid by polyelectrolyte assemblies
WO2006125086A2 (en) 2005-05-19 2006-11-23 Isoflux, Inc. Multi-layer coating system and method
US20060276910A1 (en) 2005-06-01 2006-12-07 Jan Weber Endoprostheses
WO2006133223A2 (en) 2005-06-06 2006-12-14 Innovational Holdings, Llc Implantable medical device with openings for delivery of beneficial agents with combination release kinetics
US8273117B2 (en) 2005-06-22 2012-09-25 Integran Technologies Inc. Low texture, quasi-isotropic metallic stent
US7368065B2 (en) 2005-06-23 2008-05-06 Depuy Products, Inc. Implants with textured surface and methods for producing the same
US20070038176A1 (en) 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
WO2007016961A1 (en) 2005-08-05 2007-02-15 Institut National De La Santé Et De La Recherche Médicale (Inserm) Materials useful for support and/or replacement of tissue and the use thereof for making prostheses
US7914809B2 (en) 2005-08-26 2011-03-29 Boston Scientific Scimed, Inc. Lubricious composites for medical devices
US20070048452A1 (en) 2005-09-01 2007-03-01 James Feng Apparatus and method for field-injection electrostatic spray coating of medical devices
EP1764116A1 (en) 2005-09-16 2007-03-21 Debiotech S.A. Porous coating process using colloidal particles
US20070073385A1 (en) 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
US20070065418A1 (en) 2005-09-20 2007-03-22 Franco Vallana Method and device for cellular therapy
US20070073390A1 (en) 2005-09-23 2007-03-29 Medlogics Device Corporation Methods and devices for enhanced adhesion between metallic substrates and bioactive material-containing coatings
US8008395B2 (en) 2005-09-27 2011-08-30 Boston Scientific Scimed, Inc. Organic-inorganic hybrid particle material and polymer compositions containing same
WO2007044229A2 (en) 2005-09-28 2007-04-19 Calcitec, Inc. Surface treatments for calcium phosphate-based implants
GB0522569D0 (en) 2005-11-04 2005-12-14 Univ Bath Biocompatible drug delivery device
DE102005053247A1 (en) 2005-11-08 2007-05-16 Martin Fricke Implant, in particular stent, and method for producing such an implant
US20070106347A1 (en) 2005-11-09 2007-05-10 Wun-Chen Lin Portable medical and cosmetic photon emission adjustment device and method using the same
US20070112421A1 (en) 2005-11-14 2007-05-17 O'brien Barry Medical device with a grooved surface
US7935379B2 (en) 2005-11-14 2011-05-03 Boston Scientific Scimed, Inc. Coated and imprinted medical devices and methods of making the same
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
US20070135908A1 (en) 2005-12-08 2007-06-14 Zhao Jonathon Z Absorbable stent comprising coating for controlling degradation and maintaining pH neutrality
US20070134288A1 (en) 2005-12-13 2007-06-14 Edward Parsonage Anti-adhesion agents for drug coatings
US7638156B1 (en) 2005-12-19 2009-12-29 Advanced Cardiovascular Systems, Inc. Apparatus and method for selectively coating a medical article
US20070148251A1 (en) 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
US8834912B2 (en) 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070173923A1 (en) 2006-01-20 2007-07-26 Savage Douglas R Drug reservoir stent
US20070190104A1 (en) 2006-02-13 2007-08-16 Kamath Kalpana R Coating comprising an adhesive polymeric material for a medical device and method of preparing the same
US20070191931A1 (en) 2006-02-16 2007-08-16 Jan Weber Bioerodible endoprostheses and methods of making the same
US9526814B2 (en) 2006-02-16 2016-12-27 Boston Scientific Scimed, Inc. Medical balloons and methods of making the same
EP2292178A1 (en) 2006-02-28 2011-03-09 Straumann Holding AG Two-part implant
DE102006010040B3 (en) 2006-03-04 2007-10-11 Eisenbau Krämer mbH straightener
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US8597341B2 (en) 2006-03-06 2013-12-03 David Elmaleh Intravascular device with netting system
US20070212547A1 (en) 2006-03-08 2007-09-13 Boston Scientific Scimed, Inc. Method of powder coating medical devices
EP1834606B1 (en) 2006-03-16 2013-04-24 CID S.p.A. Stents
US20070224244A1 (en) 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US7879086B2 (en) 2006-04-20 2011-02-01 Boston Scientific Scimed, Inc. Medical device having a coating comprising an adhesion promoter
US9155646B2 (en) 2006-04-27 2015-10-13 Brs Holdings, Llc Composite stent with bioremovable ceramic flakes
US20070254091A1 (en) 2006-04-28 2007-11-01 Boston Scientific Scimed, Inc. System and method for electrostatic-assisted spray coating of a medical device
US20070264303A1 (en) 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
DE602007002407D1 (en) 2006-05-17 2009-10-22 Debiotech Sa ANISOTROPE NANOPOROUS COATINGS FOR MEDICAL IMPLANTS
US8092818B2 (en) 2006-05-17 2012-01-10 Boston Scientific Scimed, Inc. Medical devices having bioactive surfaces
EP1891988A1 (en) 2006-08-07 2008-02-27 Debiotech S.A. Anisotropic nanoporous coatings for medical implants
WO2007143433A1 (en) 2006-05-31 2007-12-13 Setagon, Inc. Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation
US8778376B2 (en) 2006-06-09 2014-07-15 Advanced Cardiovascular Systems, Inc. Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating
GB0612028D0 (en) 2006-06-16 2006-07-26 Imp Innovations Ltd Bioactive glass
CA2655539A1 (en) 2006-06-21 2007-12-27 The University Of British Columbia Calcium phosphate coated implantable medical devices, and electrochemical deposition processes for making same
US8815275B2 (en) * 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
WO2008002778A2 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
US20080008654A1 (en) * 2006-07-07 2008-01-10 Boston Scientific Scimed, Inc. Medical devices having a temporary radiopaque coating
CN101588826A (en) 2006-08-02 2009-11-25 英孚拉玛特公司 Lumen-supporting devices and methods of making and using
WO2008016712A2 (en) 2006-08-02 2008-02-07 Inframat Corporation Medical devices and methods of making and using
US20080058921A1 (en) 2006-08-09 2008-03-06 Lindquist Jeffrey S Improved adhesion of a polymeric coating of a drug eluting stent
US20080057102A1 (en) 2006-08-21 2008-03-06 Wouter Roorda Methods of manufacturing medical devices for controlled drug release
US20080050413A1 (en) 2006-08-23 2008-02-28 Ronald Adrianus Maria Horvers Medical stent provided with a combination of melatonin and paclitaxel
US20080051881A1 (en) 2006-08-24 2008-02-28 Feng James Q Medical devices comprising porous layers for the release of therapeutic agents
US20080050415A1 (en) 2006-08-25 2008-02-28 Boston Scientic Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
DE102006041023B4 (en) 2006-09-01 2014-06-12 Biocer Entwicklungs Gmbh Structured coatings for implants and process for their preparation
JP2010503469A (en) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド Medical device having drug-eluting film
ES2368125T3 (en) 2006-09-15 2011-11-14 Boston Scientific Scimed, Inc. BIOEROSIONABLE ENDOPROOTHESIS WITH BIOESTABLE INORGANIC LAYERS.
CA2663212A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Magnetized bioerodible endoprosthesis
CA2663303A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis with adjustable surface features
WO2008034007A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices
US20080071353A1 (en) 2006-09-15 2008-03-20 Boston Scientific Scimed, Inc. Endoprosthesis containing magnetic induction particles
CA2663745A1 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Medical devices
WO2008036548A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
JP2010503486A (en) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド Endoprosthesis
EP2084310A1 (en) 2006-10-05 2009-08-05 Boston Scientific Limited Polymer-free coatings for medical devices formed by plasma electrolytic deposition
US8394488B2 (en) 2006-10-06 2013-03-12 Cordis Corporation Bioabsorbable device having composite structure for accelerating degradation
US20080097577A1 (en) 2006-10-20 2008-04-24 Boston Scientific Scimed, Inc. Medical device hydrogen surface treatment by electrochemical reduction
EP2088971A2 (en) 2006-11-03 2009-08-19 Boston Scientific Scimed, Inc. Ion bombardment of medical devices
JP2010508999A (en) 2006-11-09 2010-03-25 ボストン サイエンティフィック リミテッド Endoprosthesis with coating
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US20080294236A1 (en) 2007-05-23 2008-11-27 Boston Scientific Scimed, Inc. Endoprosthesis with Select Ceramic and Polymer Coatings
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
CN101199873B (en) 2006-12-14 2013-06-19 乐普(北京)医疗器械股份有限公司 Medicament elution instrument nanometer class colon washer machineole drug releasing structure and preparing method thereof
US7939095B2 (en) 2006-12-21 2011-05-10 Cordis Corporation Crosslinked silane coating for medical devices
EP2114480B1 (en) 2006-12-28 2016-01-06 Boston Scientific Limited Medical devices and methods of making the same
US20080171929A1 (en) 2007-01-11 2008-07-17 Katims Jefferson J Method for standardizing spacing between electrodes, and medical tape electrodes
CA2675633A1 (en) 2007-01-26 2008-07-31 Boston Scientific Limited Implantable medical endoprostheses
US7575593B2 (en) 2007-01-30 2009-08-18 Medtronic Vascular, Inc. Implantable device with reservoirs for increased drug loading
US8187255B2 (en) 2007-02-02 2012-05-29 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
WO2008113005A2 (en) * 2007-03-15 2008-09-18 Boston Scientific Scimed, Inc. Methods to improve the stability of cellular adhesive proteins and peptides
US20080243240A1 (en) 2007-03-26 2008-10-02 Medtronic Vascular, Inc. Biodegradable Metal Barrier Layer for a Drug-Eluting Stent
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US20080249600A1 (en) 2007-04-06 2008-10-09 Boston Scientific Scimed, Inc. Stents with drug reservoir layer and methods of making and using the same
WO2008124114A2 (en) 2007-04-09 2008-10-16 Boston Scientific Limited Stent with unconnected stent segments
JP2010524653A (en) 2007-04-25 2010-07-22 ボストン サイエンティフィック サイムド,インコーポレイテッド Medical device for therapeutic drug release and method of manufacturing the same
US20080275543A1 (en) 2007-05-02 2008-11-06 Boston Scientific Scimed, Inc. Stent
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7888719B2 (en) 2007-05-23 2011-02-15 Taiwan Semiconductor Manufacturing Co., Ltd. Semiconductor memory structures
US20080306584A1 (en) 2007-06-05 2008-12-11 Pamela Kramer-Brown Implantable medical devices for local and regional treatment
US7901452B2 (en) 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
WO2009009357A2 (en) * 2007-07-06 2009-01-15 Boston Scientific Scimed, Inc. Implantable medical devices having adjustable pore volume and methods for making the same
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) * 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090018644A1 (en) * 2007-07-13 2009-01-15 Jan Weber Boron-Enhanced Shape Memory Endoprostheses
EP2187988B1 (en) 2007-07-19 2013-08-21 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US20090028785A1 (en) * 2007-07-23 2009-01-29 Boston Scientific Scimed, Inc. Medical devices with coatings for delivery of a therapeutic agent
US20090157172A1 (en) 2007-07-24 2009-06-18 Boston Scientific Scrimed, Inc. Stents with polymer-free coatings for delivering a therapeutic agent
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US20090030504A1 (en) * 2007-07-27 2009-01-29 Boston Scientific Scimed, Inc. Medical devices comprising porous inorganic fibers for the release of therapeutic agents
WO2009020520A1 (en) 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US9248219B2 (en) 2007-09-14 2016-02-02 Boston Scientific Scimed, Inc. Medical devices having bioerodable layers for the release of therapeutic agents
US20100233226A1 (en) 2007-10-15 2010-09-16 Université Catholique de Louvain Drug-eluting nanowire array
US20090118823A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090118809A1 (en) 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
JP2011502577A (en) 2007-11-02 2011-01-27 ボストン サイエンティフィック リミテッド Degradable endoprosthesis
US20090118812A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118815A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Stent
US20090118821A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118813A1 (en) 2007-11-02 2009-05-07 Torsten Scheuermann Nano-patterned implant surfaces
US20090118818A1 (en) 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
WO2009076592A2 (en) 2007-12-12 2009-06-18 Boston Scientific Scimed, Inc. Medical devices having porous component for controlled diffusion
US20100008970A1 (en) * 2007-12-14 2010-01-14 Boston Scientific Scimed, Inc. Drug-Eluting Endoprosthesis
US7722661B2 (en) 2007-12-19 2010-05-25 Boston Scientific Scimed, Inc. Stent
US8303650B2 (en) 2008-01-10 2012-11-06 Telesis Research, Llc Biodegradable self-expanding drug-eluting prosthesis
CN101978472B (en) 2008-01-18 2012-12-26 纳米表面技术有限责任公司 Nanofilm protective and release matrices
US20090186068A1 (en) 2008-01-18 2009-07-23 Chameleon Scientific Corporation Atomic plasma deposited coatings for drug release
ES2371380T3 (en) 2008-01-24 2011-12-30 Boston Scientific Scimed, Inc. STENT TO SUPPLY A THERAPEUTIC AGENT FROM A SIDE SURFACE OF A STENT STEM.
WO2009102787A2 (en) 2008-02-12 2009-08-20 Boston Scientific Scimed, Inc. Medical implants with polysaccharide drug eluting coatings
US20100042206A1 (en) 2008-03-04 2010-02-18 Icon Medical Corp. Bioabsorbable coatings for medical devices
WO2009126766A2 (en) 2008-04-10 2009-10-15 Boston Scientific Scimed, Inc. Medical devices with an interlocking coating and methods of making the same
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US20090287301A1 (en) 2008-05-16 2009-11-19 Boston Scientific, Scimed Inc. Coating for medical implants
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8242037B2 (en) 2008-07-24 2012-08-14 The Regents Of The University Of Michigan Method of pressureless sintering production of densified ceramic composites
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2010014690A2 (en) 2008-07-31 2010-02-04 Boston Scientific Scimed, Inc. Medical devices for therapeutic agent delivery
CN102196826A (en) 2008-08-27 2011-09-21 波士顿科学医学有限公司 Medical devices having inorganic coatings for therapeutic agent delivery
JP2010063768A (en) 2008-09-12 2010-03-25 Fujifilm Corp Stent having porous film and method of manufacturing the same
JP2012501806A (en) 2008-09-12 2012-01-26 ボストン サイエンティフィック サイムド,インコーポレイテッド Stent layer manufacturing of stents
US20100070013A1 (en) 2008-09-18 2010-03-18 Medtronic Vascular, Inc. Medical Device With Microsphere Drug Delivery System
US9283304B2 (en) 2008-11-25 2016-03-15 CARDINAL HEALTH SWITZERLAND 515 GmbH Absorbable stent having a coating for controlling degradation of the stent and maintaining pH neutrality

Also Published As

Publication number Publication date
JP2009542359A (en) 2009-12-03
US8771343B2 (en) 2014-07-08
WO2008002778A3 (en) 2008-03-06
US20080004691A1 (en) 2008-01-03
EP2032091A2 (en) 2009-03-11
WO2008002778A2 (en) 2008-01-03

Similar Documents

Publication Publication Date Title
CA2655793A1 (en) Medical devices with selective coating
CA2642758A1 (en) Bioerodible endoprostheses and methods of making the same
EP2081616B1 (en) Bioerodible endoprostheses and methods of making the same
CA2642723A1 (en) Medical balloons and methods of making the same
EP2851093B1 (en) Flat process of drug coating of stents
JP4876916B2 (en) Stent
EP1795215A2 (en) Absorbable stent comprising coating for controlling degradation and maintaining pH neutrality
US20080071357A1 (en) Controlling biodegradation of a medical instrument
US20090043374A1 (en) Stent to be Placed in the Living Body
US10449065B2 (en) Method of manufacturing a tubular medical implant
JP2010505591A (en) Medical device having a porous region for controlled therapeutic agent exposure or release
WO2005117753A1 (en) Medical devices composed of porous metallic materials for delivering biolgically active materials
EP2214746A2 (en) Nano-patterned implant surfaces
CN103732159A (en) Systems for the reduction of leakage around medical devices at a treatment site
US10781294B2 (en) Surface modification of polymer foams using plasma
CA2654434A1 (en) Medical devices and related systems and methods
CN200980747Y (en) Medicine releasing structure for medicine eluting apparatus
CN105939676A (en) Anastomotic connectors
US20080071344A1 (en) Medical device with porous surface
CN109922760B (en) Drug-filled stent for preventing vascular micro-injury and manufacturing method thereof
EP3452200B1 (en) Hemofiltration device and methods of use thereof
US10799376B2 (en) Systems and method for stent manufacturing using protective shields
US20230166004A1 (en) Microcapillary Mesh Oxygen Transporter for Cell Transplantations
CA3212880A1 (en) An implantable device for branched lumens with associated systems and methods
EP3046515B1 (en) Intraluminal endoprosthesis with optimized active ingredient distribution

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20150427