CA2659974A1 - Ultrasound apparatus and methods for mixing liquids and coating stents - Google Patents
Ultrasound apparatus and methods for mixing liquids and coating stents Download PDFInfo
- Publication number
- CA2659974A1 CA2659974A1 CA002659974A CA2659974A CA2659974A1 CA 2659974 A1 CA2659974 A1 CA 2659974A1 CA 002659974 A CA002659974 A CA 002659974A CA 2659974 A CA2659974 A CA 2659974A CA 2659974 A1 CA2659974 A1 CA 2659974A1
- Authority
- CA
- Canada
- Prior art keywords
- tip
- mixing
- mixing chamber
- different
- ultrasound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
- B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
- B05B17/063—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn having an internal channel for supplying the liquid or other fluent material
Abstract
Ultrasound methods and apparatus for mixing two or more different liquids are disclosed. The ultrasound methods and apparatus may mix varied components including drugs, polymers, and coatings for application to a variety of medical apparatus surfaces. The apparatus and technique can generate a proper mixture which is uninterruptedly/continuously delivered to the surface of the medical apparatus. The apparatus may include specific ultrasound transducer/tip configurations which may allow for the mixing of different liquids in a mixing camera located inside of the vibrating tip. The apparatus and methods of the present invention may mix different drugs, applying them to stent surface using different effects like ultrasound cavitation and radiation forces. Furthermore, the disclosed methods and apparatus may generate a mixture and may deliver a targeted, gentle, highly controllable dispensation of continuous liquid spray which can reduce the loss of expensive pharmaceuticals.
Description
ULTRASOUND APPARATUS AND METHODS FOR MIXING LIQUIDS
AND COATING STENTS
BACKGROUND OF THE INVENTION
Field of the Invention The present invention relates to the coatings for medical devices and, more particularly, to apparatus and methods using ultrasound energy for mixing two or more different liquids and coating any medical device surfaces.
Background of the Related Art A stent is a generally small, cylindrical shaped, mesh tube that is inserted permanently into an artery. A stent helps hold open an artery so that blood can flow through it. Stents can generally be divided into two categories: a) Metallic Bare Stents;
and b) Drug Eluting Stents. Drug-eluting stent contain drugs that potentially reduce the chance the arteries will become blocked again.
The stents are generally tubular in design made up of fine mesh and/or wire having a small diameter and defining a large number of narrow spaces between various components.
Frequently, stents are coated with a range of materials utilizing various.
methodologies and for various reasons. Because of their specific construction, designs and materials, uniformly coating the inner and outer surfaces of the stent, repeatably with no webbing, stringing and with controllable dosage of drug-polymer coating has been problematic.
Examples of patents disclosing stents include U.S. Pat. No. 4,739,762 by Palmaz;
U.S. Pat. No. 5,133,732 by Wiktor; U.S. Pat. No. 5,292,331 by Boneau; U.S.
Pat. No.
6,908,622 by Barry et al.; U.S. Pat. No. 6,908,624 Hossayniy et al.; and U.S.
Pat. No.
6,913,617 by Reiss.
AND COATING STENTS
BACKGROUND OF THE INVENTION
Field of the Invention The present invention relates to the coatings for medical devices and, more particularly, to apparatus and methods using ultrasound energy for mixing two or more different liquids and coating any medical device surfaces.
Background of the Related Art A stent is a generally small, cylindrical shaped, mesh tube that is inserted permanently into an artery. A stent helps hold open an artery so that blood can flow through it. Stents can generally be divided into two categories: a) Metallic Bare Stents;
and b) Drug Eluting Stents. Drug-eluting stent contain drugs that potentially reduce the chance the arteries will become blocked again.
The stents are generally tubular in design made up of fine mesh and/or wire having a small diameter and defining a large number of narrow spaces between various components.
Frequently, stents are coated with a range of materials utilizing various.
methodologies and for various reasons. Because of their specific construction, designs and materials, uniformly coating the inner and outer surfaces of the stent, repeatably with no webbing, stringing and with controllable dosage of drug-polymer coating has been problematic.
Examples of patents disclosing stents include U.S. Pat. No. 4,739,762 by Palmaz;
U.S. Pat. No. 5,133,732 by Wiktor; U.S. Pat. No. 5,292,331 by Boneau; U.S.
Pat. No.
6,908,622 by Barry et al.; U.S. Pat. No. 6,908,624 Hossayniy et al.; and U.S.
Pat. No.
6,913,617 by Reiss.
There are a variety of U.S. Published Patent Applications related to stent coatings, including, for example: U.S. Pat. Pub. No. 2003/0225451 Al by Sundar; U.S.
Pat. Pub.
No. 2004/0215336 Al by Udipi, et al.; U.S. Pat. Pub. No. 2004/0224001 Al by Pacetti, et al.; U.S. Pat. Pub. No. 2004/0234748 Al by Stenzel; U.S. Pat. Pub. No.
2004/0236399 Al by Sundar; and U.S. Pat. Pub. No. 2004/0254638 Al Byun.
According to above-mentioned patents and applications, the coating have been applied to the surface of stents from both inside and outside by different methods, such as mechanical coating, gas spray coating, dipping, polarized coating, electrical charge (electrostatic) coating, ultrasound coating, etc. Some of them like U.S. Pat.
No. 6,656,506 utilize a combination of dipping and spraying). Several of them utilize the ultrasound energy, such as, for example, U.S. Pat. No. 6,767,637; and U.S. Pat. Pub. No.
2005/0064088 for ultrasound spraying. In another method, U.S. Pat. No.
5,891,507 discloses coating the surface of a stent by dipping in ultrasonic bath.
Despite these coating technologies and methods, these related technologies have numerous shortcomings and problems. For example, non-uniformity of coating thickness, webbing, stringing, bare spots on the stent surface, drug wasting, over spray, difficulties with control of drug flow volume, adhesive problems, long drying time and a need sterilization/sanitation, among others.
Ultrasonic sprayers (Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc.;
U.S.
Pat. Nos. 4,153,201, 4,655,393, and 5,516,043) typically operate by passing liquid through the central orifice of the tip of an ultrasound instrument. Known applications from US
Engineering, are use of a gas stream to deliver aerosol particles to coating surface.
Pat. Pub.
No. 2004/0215336 Al by Udipi, et al.; U.S. Pat. Pub. No. 2004/0224001 Al by Pacetti, et al.; U.S. Pat. Pub. No. 2004/0234748 Al by Stenzel; U.S. Pat. Pub. No.
2004/0236399 Al by Sundar; and U.S. Pat. Pub. No. 2004/0254638 Al Byun.
According to above-mentioned patents and applications, the coating have been applied to the surface of stents from both inside and outside by different methods, such as mechanical coating, gas spray coating, dipping, polarized coating, electrical charge (electrostatic) coating, ultrasound coating, etc. Some of them like U.S. Pat.
No. 6,656,506 utilize a combination of dipping and spraying). Several of them utilize the ultrasound energy, such as, for example, U.S. Pat. No. 6,767,637; and U.S. Pat. Pub. No.
2005/0064088 for ultrasound spraying. In another method, U.S. Pat. No.
5,891,507 discloses coating the surface of a stent by dipping in ultrasonic bath.
Despite these coating technologies and methods, these related technologies have numerous shortcomings and problems. For example, non-uniformity of coating thickness, webbing, stringing, bare spots on the stent surface, drug wasting, over spray, difficulties with control of drug flow volume, adhesive problems, long drying time and a need sterilization/sanitation, among others.
Ultrasonic sprayers (Sonic and Materials Inc., Misonix Inc., Sono-Tek Inc.;
U.S.
Pat. Nos. 4,153,201, 4,655,393, and 5,516,043) typically operate by passing liquid through the central orifice of the tip of an ultrasound instrument. Known applications from US
Engineering, are use of a gas stream to deliver aerosol particles to coating surface.
According to Sono-Tek's web site, the AccuMist and MicroMist systems are being use for ultrasonic stent coating by delivering aerosol particles via air jet or gas stream.
Among prior gas ultrasound sprayers are Celleration wound treatment applications (US pat # 5076266; 6478754; 65690,99; 6601581; 6663554), which are creating the spray.
USSR patent # 1237261, issued for Babaev in 1986 can mix the different liquid outside of ultrasound transducer tip Typically, stents need to be coated with a drug and/or polymer in single layer.
Current techniques require the drug or polymer be mixed before coating. This can lead to timing issues such as when a polymer is polymerizing after mixing.
Accordingly, there is a need for a method and device for mixing two ore more different drugs with the polymers and defect-free, controllable coating process of the stents.
SUMMARY OF THE INVENTION
According to the present invention, ultrasonic method and apparatus for stent coating'is described. The present ultrasonic method and apparatus may provide a proper mixing of two or more different liquids in a mixing chamber (camera) defined by an ultrasound transducer tip. Apparatus in.accordance with the present invention may create the uniform, gentle and targeted spray for coating of the surface.
In one aspect, the present invention is directed to interruptedly mix different liquids and coat stents with controllable thickness of layer without webbing and stringing.
In another aspect, the present invention may provide apparatus including a mixing chamber (camera) located inside of the ultrasound transducer tip. A controlled amount of different liquids from different reservoirs may be provided the mixing chamber (camera) of the ultrasonic tip. The ultrasonic tip may be cylindrical, rectangular or otherwise shaped to create proper mixture. The mixture created may delivered to distal end of the tip via central orifice to create a fine spray.
Liquid may be controllably delivered into the mixing chamber using precise syringe pumps by capillary or and gravitational action. When using syringe pumps, the amount of liquid delivered may be approximately the same volume or weight of coating layer.
A method of present invention for coating medical devices including stents can create a desired mixture inside of ultrasonic tip from different liquids, drug, polymers, among other materials and can provide uninterruptedly sprays to the surface.
Methods in accordance with the present invention may also use a number of acoustic effects of low frequency ultrasonic waves, such as cavitation, micro streaming, and standing waves inside of the mixing chamber in ultrasonic tip, which are not typically utilized in liquid mixing or coating technologies.
The method may include spinning of stent and moving of ultrasound mixing and coating head during the coating process to create special ultrasonic -acoustic effects, which will be describe in details below. All coating operation ruins with special software program to achieve high quality results.
The method and apparatus can mix different liquids such as drugs, polymers, etc., and coat rigid, flexible, self expanded stents made by different materials.
A method also may include directing the further gas flow onto mixing and coating area. Gas flow may be hot or cold and directed through mixing chamber and/or spray within particles or separate.
Among prior gas ultrasound sprayers are Celleration wound treatment applications (US pat # 5076266; 6478754; 65690,99; 6601581; 6663554), which are creating the spray.
USSR patent # 1237261, issued for Babaev in 1986 can mix the different liquid outside of ultrasound transducer tip Typically, stents need to be coated with a drug and/or polymer in single layer.
Current techniques require the drug or polymer be mixed before coating. This can lead to timing issues such as when a polymer is polymerizing after mixing.
Accordingly, there is a need for a method and device for mixing two ore more different drugs with the polymers and defect-free, controllable coating process of the stents.
SUMMARY OF THE INVENTION
According to the present invention, ultrasonic method and apparatus for stent coating'is described. The present ultrasonic method and apparatus may provide a proper mixing of two or more different liquids in a mixing chamber (camera) defined by an ultrasound transducer tip. Apparatus in.accordance with the present invention may create the uniform, gentle and targeted spray for coating of the surface.
In one aspect, the present invention is directed to interruptedly mix different liquids and coat stents with controllable thickness of layer without webbing and stringing.
In another aspect, the present invention may provide apparatus including a mixing chamber (camera) located inside of the ultrasound transducer tip. A controlled amount of different liquids from different reservoirs may be provided the mixing chamber (camera) of the ultrasonic tip. The ultrasonic tip may be cylindrical, rectangular or otherwise shaped to create proper mixture. The mixture created may delivered to distal end of the tip via central orifice to create a fine spray.
Liquid may be controllably delivered into the mixing chamber using precise syringe pumps by capillary or and gravitational action. When using syringe pumps, the amount of liquid delivered may be approximately the same volume or weight of coating layer.
A method of present invention for coating medical devices including stents can create a desired mixture inside of ultrasonic tip from different liquids, drug, polymers, among other materials and can provide uninterruptedly sprays to the surface.
Methods in accordance with the present invention may also use a number of acoustic effects of low frequency ultrasonic waves, such as cavitation, micro streaming, and standing waves inside of the mixing chamber in ultrasonic tip, which are not typically utilized in liquid mixing or coating technologies.
The method may include spinning of stent and moving of ultrasound mixing and coating head during the coating process to create special ultrasonic -acoustic effects, which will be describe in details below. All coating operation ruins with special software program to achieve high quality results.
The method and apparatus can mix different liquids such as drugs, polymers, etc., and coat rigid, flexible, self expanded stents made by different materials.
A method also may include directing the further gas flow onto mixing and coating area. Gas flow may be hot or cold and directed through mixing chamber and/or spray within particles or separate.
Device part of invention consists specific construction of ultrasonic tips, which allows mix of different liquids and uninterruptedly create the spray.
The rate of ultrasound frequency may be between 20 KHz and 20 MHz or more.
Preferable frequency is 20KHz to 200 KHz, recommended frequency is 30 KHz. The rate of ultrasound waves amplitude may be between 2 micron and 300 micron or more.
Thereby, there is provided a method and device for uninterruptedly ultrasound stent coating with proper mixing of different liquids with no webbing and stringing One aspect of this invention may be to provide a method and device for mixing two ore more different liquids.
Another aspect of the invention may be to provide a method and device for mixing two ore more unmixable liquids.
Another aspect of the invention may be to provide an improved method and device for mixing two ore more different drugs, polymers, or drug with the polymer for coating of medical implants such as a stents.
Another aspect of this invention may be to provide a method and device for mixing two ore more different liquids, such a drugs, polymers.or drug with the polymer and coating of stents using ultrasound Another aspect of this invention may be to provide method and device for mixing two ore more different drugs with the polymers, that provides controllable thickness of coating layer Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, that avoids the coating defects like webbing, stringing, etc.
Another aspect of the invention may be to provide.method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, which increases the adhesivity property of stents with no chemicals.
Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, that provides drying of coating layer along the longitudinal axis of the structure simultaneously with the coating process Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, that provides sterilization of coating layer along the longitudinal axis of the structure simultaneously with the coating process Another aspect of invention may be to provide method and device for creation of uninterrupted process of proper mixing two or more different liquids, creating the spray and coating the surface These and other aspects of the invention will become more apparent from the written description and figures below.
BRIEF DESCRIPTION OF THE DRAWINGS
The present Invention will be shown and described with reference to the drawings of preferred embodiments and clearly understood in details.
Fig. 1 is a cross sectional view of an embodiment of an ultrasonic mixing apparatus in use with the spray according to present invention.
Fig. 2 illustrates the frontal view in cross section an embodiment of an apparatus with the delivery of liquid directly to mixing camera inside of ultrasonic tip according to present invention. Liquid delivery tubes are located on one platan, perpendicular to axis of tip.
Fig, 3 illustrates the cross section of an embodiment of an apparatus with the delivery of liquid directly to mixing camera inside of ultrasonic tip according to present invention. Liquid delivery tubes are located on the platan, along ultrasonic tip's longitudinal axis.
Fig. 4 is a illustration of cross section of an embodiment of an apparatus with the threaded mixing camera inside of ultrasonic tip according to present invention.
Fig. 5 illustrates the front view of cross section. of an embodiment of an apparatus with the delivery of one liquid to mixing camera through central orifice of ultrasound transducer, and another liquid through the tube, perpendicular to ultrasonic tip's axis according to present invention Figs. 6A and 6B illustrate embodiments of mixing chambers in expanded cross section having rounded radiation walls Fig. 7 illustrates embodiments of ultrasonic tips which are a) expanded flat, b) conical shape, c) exponential d) outside rounded, e) inside rounded-focused, and f) rectangular distal end configurations.
The rate of ultrasound frequency may be between 20 KHz and 20 MHz or more.
Preferable frequency is 20KHz to 200 KHz, recommended frequency is 30 KHz. The rate of ultrasound waves amplitude may be between 2 micron and 300 micron or more.
Thereby, there is provided a method and device for uninterruptedly ultrasound stent coating with proper mixing of different liquids with no webbing and stringing One aspect of this invention may be to provide a method and device for mixing two ore more different liquids.
Another aspect of the invention may be to provide a method and device for mixing two ore more unmixable liquids.
Another aspect of the invention may be to provide an improved method and device for mixing two ore more different drugs, polymers, or drug with the polymer for coating of medical implants such as a stents.
Another aspect of this invention may be to provide a method and device for mixing two ore more different liquids, such a drugs, polymers.or drug with the polymer and coating of stents using ultrasound Another aspect of this invention may be to provide method and device for mixing two ore more different drugs with the polymers, that provides controllable thickness of coating layer Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, that avoids the coating defects like webbing, stringing, etc.
Another aspect of the invention may be to provide.method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, which increases the adhesivity property of stents with no chemicals.
Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, that provides drying of coating layer along the longitudinal axis of the structure simultaneously with the coating process Another aspect of the invention may be to provide method and device for simultaneous mixing of different liquids, creation of continuous, uniformed, directed spray from proper mixture coating of stents, that provides sterilization of coating layer along the longitudinal axis of the structure simultaneously with the coating process Another aspect of invention may be to provide method and device for creation of uninterrupted process of proper mixing two or more different liquids, creating the spray and coating the surface These and other aspects of the invention will become more apparent from the written description and figures below.
BRIEF DESCRIPTION OF THE DRAWINGS
The present Invention will be shown and described with reference to the drawings of preferred embodiments and clearly understood in details.
Fig. 1 is a cross sectional view of an embodiment of an ultrasonic mixing apparatus in use with the spray according to present invention.
Fig. 2 illustrates the frontal view in cross section an embodiment of an apparatus with the delivery of liquid directly to mixing camera inside of ultrasonic tip according to present invention. Liquid delivery tubes are located on one platan, perpendicular to axis of tip.
Fig, 3 illustrates the cross section of an embodiment of an apparatus with the delivery of liquid directly to mixing camera inside of ultrasonic tip according to present invention. Liquid delivery tubes are located on the platan, along ultrasonic tip's longitudinal axis.
Fig. 4 is a illustration of cross section of an embodiment of an apparatus with the threaded mixing camera inside of ultrasonic tip according to present invention.
Fig. 5 illustrates the front view of cross section. of an embodiment of an apparatus with the delivery of one liquid to mixing camera through central orifice of ultrasound transducer, and another liquid through the tube, perpendicular to ultrasonic tip's axis according to present invention Figs. 6A and 6B illustrate embodiments of mixing chambers in expanded cross section having rounded radiation walls Fig. 7 illustrates embodiments of ultrasonic tips which are a) expanded flat, b) conical shape, c) exponential d) outside rounded, e) inside rounded-focused, and f) rectangular distal end configurations.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides an apparatus including an ultrasonic tip 1 defining a mixing chamber (camera) 4. Preferred embodiments of the present invention in the context of a method and apparatus are illustratedthroughout the figures. Those skilled in the art will immediately understand the advantages for mixing of two or more different liquids such as a drugs and/or polymers and uninterruptedly coating the stent that will be provided by the present inventions upon review of the present disclosure.
The ultrasonic tip 1 uses ultrasonic energy provided by an ultrasound transducer 2 to mix materials and coat medical apparatus. The methods are particularly useful when applied to coating stents and other devices having intricate details and complex shapes.
Ultrasonic tips 1 in accordance with the present invention can provide highly controllable precise mixing of two or more drugs and polymers and fine, targeted spray allows the coating of stents without substantial webbing, stringing and wasting the expensive drug by mixing.
The present invention provides a novel ultrasonic tip 1 and method for mixing two or more different fluid to coat a stent. Embodiments of ultrasonic tip 1 in accordance with the present invention are illustrated in figures 1 to 7. According to present invention, ultrasonic tip 1 includes a mixing chamber/camera 4 inside of ultrasonic tip 1. The mixing chamber 4 provides ultrasonically aotive space for mixing of different liquids under acoustic forces including cavitation phenomena which can occur inside of chamber 4.
Typically, chamber 4 is of a cylindrical shape about the longitudinal axis of the ultrasonic tip 1. The cavitation phenomena may occur between walls 18 and 19 of the chamber perpendicular to longitudinal axis. One or more syringe pumps (not shown) may be provided for delivery of different liquids into chamber 4 through tubes 5, 6, 7, 8, (Fig. 2), located on the platan perpendicular to longitudinal axis. Liquid delivery tubes 6, 7, 8 may be located along longitudinal axis (fig 3) is one of the embodiment of present invention. In one aspect, one or more of the delivery tubes 6, 7, 8 may provide a pressurized fluid.
Mixtures of drugs and/or polymers may be delivered in an uninterruptedly fashion to a radiation surface 11 of tip 1 through an orifice 9 for creation of spray 10 and delivery to coating surface/stent 12. Diameter of orifice 9 preferably must be less than diameter of mixing chamber. To simplify manufacture, an ultrasound transducer 2 an ultrasonic transducer tip 1 may include a distal end part 3 which is attached via threads on planar 16 to form the chamber 4. Distal end part 3 may be provided with different diameter of central orifice 9 to create spray 10 in needed particle size. To avoid the loose of distal end part 3 has to be attached to tip 1 preferably on amplitudes node point 14.
Liquid delivery tubes (5, 6, 7, 8) also have to be attached to tip 1 preferably on amplitudes node point 20.
To achieve a high quality mixture, mixing cameras center can match or be near to the amplitudes anti node point 15.
It is important to note that gas stream with different temperature can be delivered into mixing chamber/camera 4 through one of the tubes (5, 6, 7, 8) to improve liquid mixing and spray coating process. This can change spray volume, quality and may expedite the drying process.
Clarification and description of ultrasound different liquid mixing and uninterruptedly spraying process, method and apparatus: When different liquids (a, b, c) are provided into activated mixing chamber 4, wall 19 under ultrasound radiation force delivers liquid drops / flow forward. Retrograded or ricocheted from wall 18 pressurized liquid flow encounter with fresh delivered different liquid flow and creates proper mixture under ultrasound radiation/pressure forces and cavitation.
After mixing chamber fills with liquid mixture, ultrasound pressure forces the mixture through central orifice 9 to create spray 10 and delivers it to radiation surface 11.
As the liquids are delivered and the tip vibrates, the mixing and spray coating process are occurring uninterruptedly.
In one aspect of present invention, for more effective and proper mixing process, mixing chamber 4 consists at list one thread 22, groove ring or a waved shape (Fig 5). In this case toot of tread acts as a mixing blade or spoon, forcing different liquids with ultrasonic energy to be mixed. Distal end orifice 9 also cam be threaded (23) for better mixing process.
In another aspect (Fig 6), for more effective and proper mixing process, mixing chambers wall 18 and 19 can be rounded inside (Fig 6.a) to create focused ultrasonic effect, which is much powerful. Chamber walls also can be rounded outside (Fig 6. b) for creation of powerful cavitation effect to achieve more proper mixing process.
In this case ultrasound waves being reflected from radial cylindrical walls of mixing camera forces different liquid particles toward each other. These provide proper mixing of different liquids under ultrasound cavitation and radiation pressure.
Fig. 7 is illustration of ultrasonic tip's a) expanded flat, b) conical shape, c) exponential d) outside rounded, e) inside rounded-focused and f) rectangular distal end configurations. These configurations allows to control spray angle and quality depended on coating requirements.
The present invention provides an apparatus including an ultrasonic tip 1 defining a mixing chamber (camera) 4. Preferred embodiments of the present invention in the context of a method and apparatus are illustratedthroughout the figures. Those skilled in the art will immediately understand the advantages for mixing of two or more different liquids such as a drugs and/or polymers and uninterruptedly coating the stent that will be provided by the present inventions upon review of the present disclosure.
The ultrasonic tip 1 uses ultrasonic energy provided by an ultrasound transducer 2 to mix materials and coat medical apparatus. The methods are particularly useful when applied to coating stents and other devices having intricate details and complex shapes.
Ultrasonic tips 1 in accordance with the present invention can provide highly controllable precise mixing of two or more drugs and polymers and fine, targeted spray allows the coating of stents without substantial webbing, stringing and wasting the expensive drug by mixing.
The present invention provides a novel ultrasonic tip 1 and method for mixing two or more different fluid to coat a stent. Embodiments of ultrasonic tip 1 in accordance with the present invention are illustrated in figures 1 to 7. According to present invention, ultrasonic tip 1 includes a mixing chamber/camera 4 inside of ultrasonic tip 1. The mixing chamber 4 provides ultrasonically aotive space for mixing of different liquids under acoustic forces including cavitation phenomena which can occur inside of chamber 4.
Typically, chamber 4 is of a cylindrical shape about the longitudinal axis of the ultrasonic tip 1. The cavitation phenomena may occur between walls 18 and 19 of the chamber perpendicular to longitudinal axis. One or more syringe pumps (not shown) may be provided for delivery of different liquids into chamber 4 through tubes 5, 6, 7, 8, (Fig. 2), located on the platan perpendicular to longitudinal axis. Liquid delivery tubes 6, 7, 8 may be located along longitudinal axis (fig 3) is one of the embodiment of present invention. In one aspect, one or more of the delivery tubes 6, 7, 8 may provide a pressurized fluid.
Mixtures of drugs and/or polymers may be delivered in an uninterruptedly fashion to a radiation surface 11 of tip 1 through an orifice 9 for creation of spray 10 and delivery to coating surface/stent 12. Diameter of orifice 9 preferably must be less than diameter of mixing chamber. To simplify manufacture, an ultrasound transducer 2 an ultrasonic transducer tip 1 may include a distal end part 3 which is attached via threads on planar 16 to form the chamber 4. Distal end part 3 may be provided with different diameter of central orifice 9 to create spray 10 in needed particle size. To avoid the loose of distal end part 3 has to be attached to tip 1 preferably on amplitudes node point 14.
Liquid delivery tubes (5, 6, 7, 8) also have to be attached to tip 1 preferably on amplitudes node point 20.
To achieve a high quality mixture, mixing cameras center can match or be near to the amplitudes anti node point 15.
It is important to note that gas stream with different temperature can be delivered into mixing chamber/camera 4 through one of the tubes (5, 6, 7, 8) to improve liquid mixing and spray coating process. This can change spray volume, quality and may expedite the drying process.
Clarification and description of ultrasound different liquid mixing and uninterruptedly spraying process, method and apparatus: When different liquids (a, b, c) are provided into activated mixing chamber 4, wall 19 under ultrasound radiation force delivers liquid drops / flow forward. Retrograded or ricocheted from wall 18 pressurized liquid flow encounter with fresh delivered different liquid flow and creates proper mixture under ultrasound radiation/pressure forces and cavitation.
After mixing chamber fills with liquid mixture, ultrasound pressure forces the mixture through central orifice 9 to create spray 10 and delivers it to radiation surface 11.
As the liquids are delivered and the tip vibrates, the mixing and spray coating process are occurring uninterruptedly.
In one aspect of present invention, for more effective and proper mixing process, mixing chamber 4 consists at list one thread 22, groove ring or a waved shape (Fig 5). In this case toot of tread acts as a mixing blade or spoon, forcing different liquids with ultrasonic energy to be mixed. Distal end orifice 9 also cam be threaded (23) for better mixing process.
In another aspect (Fig 6), for more effective and proper mixing process, mixing chambers wall 18 and 19 can be rounded inside (Fig 6.a) to create focused ultrasonic effect, which is much powerful. Chamber walls also can be rounded outside (Fig 6. b) for creation of powerful cavitation effect to achieve more proper mixing process.
In this case ultrasound waves being reflected from radial cylindrical walls of mixing camera forces different liquid particles toward each other. These provide proper mixing of different liquids under ultrasound cavitation and radiation pressure.
Fig. 7 is illustration of ultrasonic tip's a) expanded flat, b) conical shape, c) exponential d) outside rounded, e) inside rounded-focused and f) rectangular distal end configurations. These configurations allows to control spray angle and quality depended on coating requirements.
Claims (15)
1. An apparatus for mixing at least two different liquids and coating at least portion of at least one stent comprising: a) an ultrasound transducer having a tip;
b) an ultrasound transducer tip having mixing chamber inside of the vibrating tip;
c) an ultrasound transducer tip's mixing chamber having tubes to deliver liquid into chamber; and d) an ultrasound transducer tip's mixing chamber having central orifice to provide mixture of liquid to the distal end of tip to be sprayed;
b) an ultrasound transducer tip having mixing chamber inside of the vibrating tip;
c) an ultrasound transducer tip's mixing chamber having tubes to deliver liquid into chamber; and d) an ultrasound transducer tip's mixing chamber having central orifice to provide mixture of liquid to the distal end of tip to be sprayed;
2. An apparatus of claim 1, wherein ultrasonic tip's mixing chamber has a thread or groove
3. An apparatus of claim 1, wherein ultrasonic tip's mixing chamber has front end part, attached to tip on node point via thread;
4. An apparatus of claim 1, wherein ultrasonic tip's mixing chamber has liquid delivery tubes, attached to tip on node point.
5. An apparatus of claim 1, wherein ultrasonic tip's front end part has a different geometrical form/shape;
6. An apparatus of claim 1, wherein ultrasonic tip's mixing chamber has a thread or groove
7. An apparatus of claim 1, wherein liquid mixing chamber's at least one of rear and/or front walls are flat;
8. An apparatus of claim 1, wherein liquid mixing chamber's at least one of rear and/or front walls are round or oval;
9. An apparatus of claim 1, wherein liquid mixing chamber's diameter is greater than front end part's central orifice diameter;
10. A method for mixing at least two different liquids, comprising:
a) having ultrasound transducer tip with mixing chamber, provided inside of vibrating tip b) delivering at least two different liquids into mixing camera c) delivering at list two different liquids and at least one gas stream via one of the liquid delivery tube c) creating mixture at least from two different liquids using ultrasound cavitation and radiation forces d) delivering the mixture to distal end of tip via central orifice to create the spray e) directing and applying a mixture coating spray onto the stent.
a) having ultrasound transducer tip with mixing chamber, provided inside of vibrating tip b) delivering at least two different liquids into mixing camera c) delivering at list two different liquids and at least one gas stream via one of the liquid delivery tube c) creating mixture at least from two different liquids using ultrasound cavitation and radiation forces d) delivering the mixture to distal end of tip via central orifice to create the spray e) directing and applying a mixture coating spray onto the stent.
11. The method of claim 10, comprising use of different ultrasound wave frequencies for mixing of different liquids inside of vibrating tip.
12. The method of claim 10, further comprising use of different ultrasound wave amplitudes for mixing of different liquids inside of vibrating tip.
13. The method of claim 10, wherein at least one of the liquids is a therapeutic agent/drug.
14. The method of claim 10, wherein at least one of the liquids is a polymer.
15. The method of claim 10, wherein one of the liquids is a mixture.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/204,872 | 2005-08-16 | ||
US11/204,872 US7896539B2 (en) | 2005-08-16 | 2005-08-16 | Ultrasound apparatus and methods for mixing liquids and coating stents |
PCT/US2006/027895 WO2007021427A2 (en) | 2005-08-16 | 2006-07-18 | Ultrasound apparatus and methods for mixing liquids and coating stents |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2659974A1 true CA2659974A1 (en) | 2007-02-22 |
Family
ID=37758024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002659974A Abandoned CA2659974A1 (en) | 2005-08-16 | 2006-07-18 | Ultrasound apparatus and methods for mixing liquids and coating stents |
Country Status (9)
Country | Link |
---|---|
US (2) | US7896539B2 (en) |
EP (1) | EP1915218B1 (en) |
JP (1) | JP2009504396A (en) |
KR (1) | KR20080040728A (en) |
CN (1) | CN101242907A (en) |
AT (1) | ATE460230T1 (en) |
CA (1) | CA2659974A1 (en) |
DE (1) | DE602006012847D1 (en) |
WO (1) | WO2007021427A2 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040030254A1 (en) * | 2002-08-07 | 2004-02-12 | Eilaz Babaev | Device and method for ultrasound wound debridement |
US7947010B2 (en) * | 2005-07-08 | 2011-05-24 | Depuy Products, Inc. | Composition and system for wound decontamination |
US20070031611A1 (en) * | 2005-08-04 | 2007-02-08 | Babaev Eilaz P | Ultrasound medical stent coating method and device |
US7896539B2 (en) * | 2005-08-16 | 2011-03-01 | Bacoustics, Llc | Ultrasound apparatus and methods for mixing liquids and coating stents |
US7943352B2 (en) | 2006-03-29 | 2011-05-17 | Bacoustics, Llc | Apparatus and methods for vaccine development using ultrasound technology |
US7846341B2 (en) * | 2006-12-04 | 2010-12-07 | Bacoustics, Llc | Method of ultrasonically treating a continuous flow of fluid |
US20080243047A1 (en) * | 2007-03-27 | 2008-10-02 | Babaev Eilaz P | Ultrasound wound care device |
US20080265052A1 (en) * | 2007-04-30 | 2008-10-30 | Ke-Ming Quan | Method of using an ultrasonic spray apparatus to coat a substrate |
US20080265055A1 (en) * | 2007-04-30 | 2008-10-30 | Ke-Ming Quan | Ultrasonic nozzle |
US7901388B2 (en) | 2007-07-13 | 2011-03-08 | Bacoustics, Llc | Method of treating wounds by creating a therapeutic solution with ultrasonic waves |
US7753285B2 (en) * | 2007-07-13 | 2010-07-13 | Bacoustics, Llc | Echoing ultrasound atomization and/or mixing system |
US7780095B2 (en) | 2007-07-13 | 2010-08-24 | Bacoustics, Llc | Ultrasound pumping apparatus |
US20100324481A1 (en) * | 2007-07-13 | 2010-12-23 | Bacoustics, Llc | Ultrasound pumping apparatus for use with the human body |
US7896854B2 (en) * | 2007-07-13 | 2011-03-01 | Bacoustics, Llc | Method of treating wounds by creating a therapeutic solution with ultrasonic waves |
US20110160624A1 (en) * | 2007-07-13 | 2011-06-30 | Bacoustics, Llc | Apparatus for creating a therapeutic solution and debridement with ultrasound energy |
US20090093870A1 (en) * | 2007-10-05 | 2009-04-09 | Bacoustics, Llc | Method for Holding a Medical Device During Coating |
US8689728B2 (en) * | 2007-10-05 | 2014-04-08 | Menendez Adolfo | Apparatus for holding a medical device during coating |
US8016208B2 (en) | 2008-02-08 | 2011-09-13 | Bacoustics, Llc | Echoing ultrasound atomization and mixing system |
US7950594B2 (en) * | 2008-02-11 | 2011-05-31 | Bacoustics, Llc | Mechanical and ultrasound atomization and mixing system |
US7830070B2 (en) * | 2008-02-12 | 2010-11-09 | Bacoustics, Llc | Ultrasound atomization system |
US9565870B2 (en) | 2011-11-01 | 2017-02-14 | Pepsico, Inc. | Dispensing nozzle with an ultrasound activator |
KR102645914B1 (en) | 2015-10-30 | 2024-03-12 | 존슨 앤드 존슨 컨수머 인코포레이티드 | Sterile Aerosol Misting Device |
US20170128972A1 (en) | 2015-10-30 | 2017-05-11 | Johnson & Johnson Consumer Inc. | Aseptic aerosol misting device |
CA3001619A1 (en) | 2015-10-30 | 2017-05-04 | Johnson & Johnson Consumer Inc. | Unit dose aseptic aerosol misting device |
MA54688A (en) * | 2015-10-30 | 2021-11-17 | Johnson & Johnson Consumer Inc | ASEPTIC AEROSOL NEBULIZER |
AU2017376132A1 (en) * | 2016-12-12 | 2019-07-11 | Neuronoff, Inc. | Electrode curable and moldable to contours of a target in bodily tissue and methods of manufacturing and placement and dispensers therefor |
CN114606499B (en) * | 2022-04-07 | 2023-06-06 | 燕山大学 | Metal with microporous structure on surface and preparation method and application thereof |
Family Cites Families (227)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE634668A (en) | 1962-07-11 | |||
US3373752A (en) * | 1962-11-13 | 1968-03-19 | Inoue Kiyoshi | Method for the ultrasonic cleaning of surfaces |
US3334818A (en) * | 1965-09-22 | 1967-08-08 | Alfred M Moen | Swivel spray aerators |
US3400892A (en) * | 1965-12-02 | 1968-09-10 | Battelle Development Corp | Resonant vibratory apparatus |
US3561444A (en) | 1968-05-22 | 1971-02-09 | Bio Logics Inc | Ultrasonic drug nebulizer |
US3663288A (en) | 1969-09-04 | 1972-05-16 | American Cyanamid Co | Physiologically acceptible elastomeric article |
US3608832A (en) * | 1969-09-04 | 1971-09-28 | Energy Sciences Inc | Spray nozzle assembly operable at low pressure |
CS148449B1 (en) | 1970-03-13 | 1973-02-22 | ||
DE2445791C2 (en) | 1974-09-25 | 1984-04-19 | Siemens AG, 1000 Berlin und 8000 München | Ultrasonic liquid atomizer |
GB1528163A (en) | 1975-02-10 | 1978-10-11 | Agfa Gevaert | Process for the hardening of photographic layers |
US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
US4301968A (en) * | 1976-11-08 | 1981-11-24 | Sono-Tek Corporation | Transducer assembly, ultrasonic atomizer and fuel burner |
US4391797A (en) | 1977-01-05 | 1983-07-05 | The Children's Hospital Medical Center | Systems for the controlled release of macromolecules |
US4119094A (en) | 1977-08-08 | 1978-10-10 | Biosearch Medical Products Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US4100309A (en) | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
DE2811248C3 (en) | 1978-03-15 | 1981-11-26 | Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart | Liquid atomizer |
FR2443113B1 (en) | 1978-06-30 | 1985-12-06 | Deutsch Pruef Messgeraete | METHOD AND DEVICE FOR TRANSMITTING ACOUSTIC PULSES, PARTICULARLY IN THE FIELD OF ULTRA-SOUNDS, AND APPLICATION OF SUCH PULSES IN PARTICULAR TO NON-DESTRUCTIVE CONTROL OF MATERIALS |
JPS5848225B2 (en) | 1979-01-09 | 1983-10-27 | オムロン株式会社 | Atomization amount control method of ultrasonic liquid atomization device |
US4263188A (en) | 1979-05-23 | 1981-04-21 | Verbatim Corporation | Aqueous coating composition and method |
DE2930410A1 (en) | 1979-07-26 | 1981-02-12 | Bayer Ag | PROCESS FOR THE PRODUCTION OF STABLE Aqueous DISPERSIONS OF OLIGO- OR POLYURETHANES, AND THEIR USE AS A COATING AGENT FOR FLEXIBLE OR NON-FLEXIBLE SUBSTRATES |
US4387024A (en) | 1979-12-13 | 1983-06-07 | Toray Industries, Inc. | High performance semipermeable composite membrane and process for producing the same |
US4675361A (en) | 1980-02-29 | 1987-06-23 | Thoratec Laboratories Corp. | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
US4306816A (en) * | 1980-04-04 | 1981-12-22 | Folland Corporation | Barodynamic resonator |
US4402458A (en) | 1980-04-12 | 1983-09-06 | Battelle-Institut E.V. | Apparatus for atomizing liquids |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4373009A (en) | 1981-05-18 | 1983-02-08 | International Silicone Corporation | Method of forming a hydrophilic coating on a substrate |
US4487808A (en) | 1982-04-22 | 1984-12-11 | Astra Meditec Aktiebolag | Medical article having a hydrophilic coating |
SE430695B (en) | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | PROCEDURE FOR THE PREPARATION OF A HYDROPHILIC COATING AND ACCORDING TO THE PROCEDURE OF MEDICAL ARTICLES |
SE430696B (en) | 1982-04-22 | 1983-12-05 | Astra Meditec Ab | PROCEDURE FOR THE PREPARATION OF A HYDROPHILIC COATING AND ANY PROCEDURE MANUFACTURED MEDICAL ARTICLE |
US4499154A (en) | 1982-09-03 | 1985-02-12 | Howard L. Podell | Dipped rubber article |
US4536179A (en) | 1982-09-24 | 1985-08-20 | University Of Minnesota | Implantable catheters with non-adherent contacting polymer surfaces |
US5002582A (en) | 1982-09-29 | 1991-03-26 | Bio-Metric Systems, Inc. | Preparation of polymeric surfaces via covalently attaching polymers |
US4541564A (en) * | 1983-01-05 | 1985-09-17 | Sono-Tek Corporation | Ultrasonic liquid atomizer, particularly for high volume flow rates |
US4492622A (en) | 1983-09-02 | 1985-01-08 | Honeywell Inc. | Clark cell with hydrophylic polymer layer |
SE452404B (en) | 1984-02-03 | 1987-11-30 | Medinvent Sa | MULTILAYER PROTEST MATERIAL AND PROCEDURE FOR ITS MANUFACTURING |
SU1237261A2 (en) | 1984-04-09 | 1986-06-15 | Центр Методологии Изобретательства | Apparatus for ultrasound spraying of liquid medium |
EP0166998B1 (en) | 1984-06-04 | 1991-05-08 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Medical instrument and method for making |
US4684328A (en) | 1984-06-28 | 1987-08-04 | Piezo Electric Products, Inc. | Acoustic pump |
US5037677A (en) | 1984-08-23 | 1991-08-06 | Gregory Halpern | Method of interlaminar grafting of coatings |
US4959074A (en) | 1984-08-23 | 1990-09-25 | Gergory Halpern | Method of hydrophilic coating of plastics |
DE3574344D1 (en) | 1984-08-29 | 1989-12-28 | Omron Tateisi Electronics Co | Ultrasonic atomizer |
US4582654A (en) | 1984-09-12 | 1986-04-15 | Varian Associates, Inc. | Nebulizer particularly adapted for analytical purposes |
US4642267A (en) | 1985-05-06 | 1987-02-10 | Hydromer, Inc. | Hydrophilic polymer blend |
JPS61259784A (en) | 1985-05-13 | 1986-11-18 | Toa Nenryo Kogyo Kk | Vibrator for ultrasonic injection |
US5057371A (en) | 1985-06-14 | 1991-10-15 | Minnesota Mining And Manufacturing Company | Aziridine-treated articles |
US4923464A (en) | 1985-09-03 | 1990-05-08 | Becton, Dickinson And Company | Percutaneously deliverable intravascular reconstruction prosthesis |
US4659014A (en) * | 1985-09-05 | 1987-04-21 | Delavan Corporation | Ultrasonic spray nozzle and method |
US4705709A (en) | 1985-09-25 | 1987-11-10 | Sherwood Medical Company | Lubricant composition, method of coating and a coated intubation device |
US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
US4748986A (en) | 1985-11-26 | 1988-06-07 | Advanced Cardiovascular Systems, Inc. | Floppy guide wire with opaque tip |
JPH065060B2 (en) | 1985-12-25 | 1994-01-19 | 株式会社日立製作所 | Drive circuit for ultrasonic fuel atomizer for internal combustion engine |
DE3786721D1 (en) | 1986-02-24 | 1993-09-02 | Fischell Robert | DEVICE FOR DETECTING BLOOD VESSELS AND SYSTEM FOR ITS INTRODUCTION. |
GB2189168B (en) | 1986-04-21 | 1989-11-29 | Aligena Ag | Composite membranes useful in the separation of low molecular weight organic compounds from aqueous solutions containing inorganic salts |
US4721117A (en) | 1986-04-25 | 1988-01-26 | Advanced Cardiovascular Systems, Inc. | Torsionally stabilized guide wire with outer jacket |
US4692352A (en) | 1986-04-29 | 1987-09-08 | The Kendall Company | Method of making an adhesive tape |
US4867173A (en) | 1986-06-30 | 1989-09-19 | Meadox Surgimed A/S | Steerable guidewire |
DE3627222A1 (en) | 1986-08-11 | 1988-02-18 | Siemens Ag | ULTRASONIC POCKET SPRAYER |
US5037656A (en) | 1986-12-04 | 1991-08-06 | Millipore Corporation | Porous membrane having hydrophilic and cell growth promotions surface and process |
US4834124A (en) * | 1987-01-09 | 1989-05-30 | Honda Electronics Co., Ltd. | Ultrasonic cleaning device |
US4734092A (en) | 1987-02-18 | 1988-03-29 | Ivac Corporation | Ambulatory drug delivery device |
US5211183A (en) | 1987-05-13 | 1993-05-18 | Wilson Bruce C | Steerable memory alloy guide wires |
US4850534A (en) | 1987-05-30 | 1989-07-25 | Tdk Corporation | Ultrasonic wave nebulizer |
US5527337A (en) | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
US4795458A (en) | 1987-07-02 | 1989-01-03 | Regan Barrie F | Stent for use following balloon angioplasty |
JPH088933B2 (en) | 1987-07-10 | 1996-01-31 | 日本ゼオン株式会社 | Catheter |
JPS6458263A (en) | 1987-08-28 | 1989-03-06 | Terumo Corp | Intravascular introducing catheter |
US4964409A (en) | 1989-05-11 | 1990-10-23 | Advanced Cardiovascular Systems, Inc. | Flexible hollow guiding member with means for fluid communication therethrough |
CS270372B1 (en) | 1987-12-09 | 1990-06-13 | Sulc Jiri | Method of thin hydrophilic layers formation on surface of articles of non-hydrophilic methacrylic and acrylic polymers |
US4841976A (en) | 1987-12-17 | 1989-06-27 | Schneider-Shiley (Usa) Inc. | Steerable catheter guide |
US4980231A (en) | 1988-02-19 | 1990-12-25 | Snyder Laboratories, Inc. | Process for coating polymer surfaces and coated products produced using such process |
US4943460A (en) | 1988-02-19 | 1990-07-24 | Snyder Laboratories, Inc. | Process for coating polymer surfaces and coated products produced using such process |
US4925698A (en) | 1988-02-23 | 1990-05-15 | Tekmat Corporation | Surface modification of polymeric materials |
JP2670680B2 (en) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | Polylactic acid microspheres containing physiologically active substance and method for producing the same |
US4884579A (en) | 1988-04-18 | 1989-12-05 | Target Therapeutics | Catheter guide wire |
JPH01300958A (en) | 1988-05-31 | 1989-12-05 | Canon Inc | Intraocular lens having surface functional film |
WO1990001344A1 (en) | 1988-08-09 | 1990-02-22 | Toray Industries, Inc. | Slippery medical material and process for its production |
US5067489A (en) | 1988-08-16 | 1991-11-26 | Flexmedics Corporation | Flexible guide with safety tip |
CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
US5470829A (en) | 1988-11-17 | 1995-11-28 | Prisell; Per | Pharmaceutical preparation |
JPH0777720B2 (en) * | 1988-11-22 | 1995-08-23 | 工業技術院長 | Water jet nozzle |
EP0373237A1 (en) | 1988-12-13 | 1990-06-20 | Siemens Aktiengesellschaft | Pocket inhaler device |
US5091205A (en) | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
JPH03505424A (en) | 1989-04-14 | 1991-11-28 | アゼルバイジャンスキ ポリテフニチェスキ インスティテュト イメニ チェー.イルドリマ | Ultrasonic atomization device for liquid media |
US5080924A (en) | 1989-04-24 | 1992-01-14 | Drexel University | Method of making biocompatible, surface modified materials |
US5202066A (en) * | 1989-04-25 | 1993-04-13 | Idemitsu Kosan Co., Ltd. | Method of plasticizing molding material and apparatus therefor |
US5069226A (en) | 1989-04-28 | 1991-12-03 | Tokin Corporation | Catheter guidewire with pseudo elastic shape memory alloy |
US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5128170A (en) | 1989-05-11 | 1992-07-07 | Kanegafunchi Kagaku Kogyo Kabushiki Kaisha | Method for manufacturing medical device having a highly biocompatible surface |
US5026607A (en) | 1989-06-23 | 1991-06-25 | C. R. Bard, Inc. | Medical apparatus having protective, lubricious coating |
US5017383A (en) | 1989-08-22 | 1991-05-21 | Taisho Pharmaceutical Co., Ltd. | Method of producing fine coated pharmaceutical preparation |
US5049403A (en) | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5066705A (en) | 1990-01-17 | 1991-11-19 | The Glidden Company | Ambient cure protective coatings for plastic substrates |
US5084315A (en) | 1990-02-01 | 1992-01-28 | Becton, Dickinson And Company | Lubricious coatings, medical articles containing same and method for their preparation |
US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
US5008363A (en) | 1990-03-23 | 1991-04-16 | Union Carbide Chemicals And Plastics Technology Corporation | Low temperature active aliphatic aromatic polycarbodiimides |
US5107852A (en) | 1990-04-02 | 1992-04-28 | W. L. Gore & Associates, Inc. | Catheter guidewire device having a covering of fluoropolymer tape |
US5344426A (en) | 1990-04-25 | 1994-09-06 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
WO1991017724A1 (en) | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
US5069217A (en) | 1990-07-09 | 1991-12-03 | Lake Region Manufacturing Co., Inc. | Steerable guide wire |
US5040543A (en) | 1990-07-25 | 1991-08-20 | C. R. Bard, Inc. | Movable core guidewire |
US5102401A (en) | 1990-08-22 | 1992-04-07 | Becton, Dickinson And Company | Expandable catheter having hydrophobic surface |
US5449372A (en) | 1990-10-09 | 1995-09-12 | Scimed Lifesystems, Inc. | Temporary stent and methods for use and manufacture |
SE467309B (en) | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | HYDROPHILIZED FIXED SURFACE, PROCEDURE FOR ITS PREPARATION AND AGENTS THEREOF |
SE467308B (en) | 1990-10-22 | 1992-06-29 | Berol Nobel Ab | SOLID SURFACE COATED WITH A HYDROPHILIC SURFACE WITH COVALENTLY BONDED BIOPOLYMERS, SET TO MAKE SUCH A SURFACE AND CONJUGATED THEREOF |
US5160790A (en) | 1990-11-01 | 1992-11-03 | C. R. Bard, Inc. | Lubricious hydrogel coatings |
US5102402A (en) | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5324261A (en) | 1991-01-04 | 1994-06-28 | Medtronic, Inc. | Drug delivery balloon catheter with line of weakness |
US5266359A (en) | 1991-01-14 | 1993-11-30 | Becton, Dickinson And Company | Lubricative coating composition, article and assembly containing same and method thereof |
AU1579092A (en) | 1991-02-27 | 1992-10-06 | Nova Pharmaceutical Corporation | Anti-infective and anti-inflammatory releasing systems for medical devices |
EP0504881B2 (en) | 1991-03-22 | 2000-11-08 | Katsuro Tachibana | Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same |
US5241970A (en) | 1991-05-17 | 1993-09-07 | Wilson-Cook Medical, Inc. | Papillotome/sphincterotome procedures and a wire guide specially |
US5147370A (en) | 1991-06-12 | 1992-09-15 | Mcnamara Thomas O | Nitinol stent for hollow body conduits |
US5105010A (en) | 1991-06-13 | 1992-04-14 | Ppg Industries, Inc. | Carbodiimide compounds, polymers containing same and coating compositions containing said polymers |
US5213111A (en) | 1991-07-10 | 1993-05-25 | Cook Incorporated | Composite wire guide construction |
US5188621A (en) | 1991-08-26 | 1993-02-23 | Target Therapeutics Inc. | Extendable guidewire assembly |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5234457A (en) | 1991-10-09 | 1993-08-10 | Boston Scientific Corporation | Impregnated stent |
CA2380683C (en) | 1991-10-28 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Expandable stents and method for making same |
GB2291605B (en) | 1991-11-12 | 1996-05-01 | Medix Ltd | A nebuliser and nebuliser control system |
US5243996A (en) | 1992-01-03 | 1993-09-14 | Cook, Incorporated | Small-diameter superelastic wire guide |
JP2769261B2 (en) * | 1992-01-28 | 1998-06-25 | 三菱電機株式会社 | Microcomputer |
CA2087132A1 (en) | 1992-01-31 | 1993-08-01 | Michael S. Williams | Stent capable of attachment within a body lumen |
US5283063A (en) | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
ZA93929B (en) | 1992-02-18 | 1993-09-10 | Akzo Nv | A process for the preparation of biologically active materialcontaining polymeric microcapsules. |
FR2688401B1 (en) | 1992-03-12 | 1998-02-27 | Thierry Richard | EXPANDABLE STENT FOR HUMAN OR ANIMAL TUBULAR MEMBER, AND IMPLEMENTATION TOOL. |
US5282823A (en) | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5217026A (en) | 1992-04-06 | 1993-06-08 | Kingston Technologies, Inc. | Guidewires with lubricious surface and method of their production |
WO1993020949A1 (en) | 1992-04-09 | 1993-10-28 | Omron Corporation | Ultrasonic atomizer, ultrasonic inhalator and method of controlling same |
JPH05293431A (en) | 1992-04-21 | 1993-11-09 | Fuji Photo Film Co Ltd | Coating method |
US5382261A (en) | 1992-09-01 | 1995-01-17 | Expandable Grafts Partnership | Method and apparatus for occluding vessels |
US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5449382A (en) | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5443458A (en) | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
GB9226791D0 (en) | 1992-12-23 | 1993-02-17 | Biocompatibles Ltd | New materials |
US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
KR960015447B1 (en) | 1993-03-16 | 1996-11-14 | 주식회사 삼양사 | Biodegradable polymer |
WO1994021308A1 (en) | 1993-03-18 | 1994-09-29 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
PT1118325E (en) | 1993-07-29 | 2006-05-31 | Us Health | USES OF PACLITAXEL AND ITS DERIVATIVES IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF RESTENOSE |
CH686872A5 (en) | 1993-08-09 | 1996-07-31 | Disetronic Ag | Medical Inhalationsgeraet. |
US5380299A (en) | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
GB9324250D0 (en) | 1993-11-25 | 1994-01-12 | Minnesota Mining & Mfg | Inhaler |
KR0148704B1 (en) | 1994-01-10 | 1998-08-17 | 김상응 | Biodegradable polymer as drug delivery |
GB9415926D0 (en) | 1994-08-04 | 1994-09-28 | Biocompatibles Ltd | New materials |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5637113A (en) | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
US5576072A (en) | 1995-02-01 | 1996-11-19 | Schneider (Usa), Inc. | Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US5702754A (en) | 1995-02-22 | 1997-12-30 | Meadox Medicals, Inc. | Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings |
US5869127A (en) | 1995-02-22 | 1999-02-09 | Boston Scientific Corporation | Method of providing a substrate with a bio-active/biocompatible coating |
WO1996025897A2 (en) | 1995-02-22 | 1996-08-29 | Menlo Care, Inc. | Covered expanding mesh stent |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US5620738A (en) | 1995-06-07 | 1997-04-15 | Union Carbide Chemicals & Plastics Technology Corporation | Non-reactive lubicious coating process |
US5597292A (en) | 1995-06-14 | 1997-01-28 | Alliedsignal, Inc. | Piezoelectric booster pump for a braking system |
US6041253A (en) | 1995-12-18 | 2000-03-21 | Massachusetts Institute Of Technology | Effect of electric field and ultrasound for transdermal drug delivery |
AU4238096A (en) * | 1995-11-15 | 1997-06-05 | Aeropag Usa, Inc. | Method of spraying a surface using ultrasonic radiation |
US6720710B1 (en) | 1996-01-05 | 2004-04-13 | Berkeley Microinstruments, Inc. | Micropump |
US5799732A (en) | 1996-01-31 | 1998-09-01 | Schlumberger Technology Corporation | Small hole retrievable perforating system for use during extreme overbalanced perforating |
JP2002515786A (en) | 1996-06-28 | 2002-05-28 | ソントラ メディカル,エル.ピー. | Ultrasound enhancement of transdermal delivery |
US6099561A (en) | 1996-10-21 | 2000-08-08 | Inflow Dynamics, Inc. | Vascular and endoluminal stents with improved coatings |
US6251099B1 (en) | 1996-11-27 | 2001-06-26 | The General Hospital Corporation | Compound delivery using impulse transients |
JP2001507702A (en) | 1996-12-31 | 2001-06-12 | インヘイル・セラピューティックス・システムズ・インコーポレテッド | Method for spray drying an aqueous suspension of a hydrophobic drug having a hydrophilic excipient and a composition made by the method |
US5785972A (en) | 1997-01-10 | 1998-07-28 | Tyler; Kathleen A. | Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application |
US6776792B1 (en) | 1997-04-24 | 2004-08-17 | Advanced Cardiovascular Systems Inc. | Coated endovascular stent |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US5972027A (en) | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
US5957975A (en) | 1997-12-15 | 1999-09-28 | The Cleveland Clinic Foundation | Stent having a programmed pattern of in vivo degradation |
US6104952A (en) | 1998-01-07 | 2000-08-15 | Tu; Lily Chen | Devices for treating canker sores, tissues and methods thereof |
CA2317777C (en) | 1998-01-08 | 2005-05-03 | Sontra Medical, Inc. | Sonophoretic enhanced transdermal transport |
US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
US6102298A (en) | 1998-02-23 | 2000-08-15 | The Procter & Gamble Company | Ultrasonic spray coating application system |
US6296630B1 (en) | 1998-04-08 | 2001-10-02 | Biocardia, Inc. | Device and method to slow or stop the heart temporarily |
US6369039B1 (en) | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
US6299604B1 (en) | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
US6335029B1 (en) | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
US6283626B1 (en) * | 1998-10-02 | 2001-09-04 | Institute For Advanced Engineering | Multiphase mixing apparatus using acoustic resonance |
US6234765B1 (en) | 1999-02-26 | 2001-05-22 | Acme Widgets Research & Development, Llc | Ultrasonic phase pump |
US6730349B2 (en) | 1999-04-19 | 2004-05-04 | Scimed Life Systems, Inc. | Mechanical and acoustical suspension coating of medical implants |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
AU2001228653A1 (en) | 2000-01-24 | 2001-07-31 | Biocompatibles Limited | Coated implants |
US20040211362A1 (en) | 2000-05-31 | 2004-10-28 | Daniel Castro | System for coating a stent |
US6638249B1 (en) | 2000-07-17 | 2003-10-28 | Wisconsin Alumni Research Foundation | Ultrasonically actuated needle pump system |
US6964647B1 (en) * | 2000-10-06 | 2005-11-15 | Ellaz Babaev | Nozzle for ultrasound wound treatment |
SE517421C2 (en) | 2000-10-06 | 2002-06-04 | Bioglan Ab | New production of microparticles involves use of aqueous solution of purified amylopectin-based starch of reduced molecular weight |
US6601581B1 (en) | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
US6569099B1 (en) | 2001-01-12 | 2003-05-27 | Eilaz Babaev | Ultrasonic method and device for wound treatment |
US6706337B2 (en) | 2001-03-12 | 2004-03-16 | Agfa Corporation | Ultrasonic method for applying a coating material onto a substrate and for cleaning the coating material from the substrate |
US6623444B2 (en) * | 2001-03-21 | 2003-09-23 | Advanced Medical Applications, Inc. | Ultrasonic catheter drug delivery method and device |
US6749406B2 (en) | 2001-04-09 | 2004-06-15 | George Keilman | Ultrasonic pump with non-planar transducer for generating focused longitudinal waves and pumping methods |
US6478754B1 (en) | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
US6669103B2 (en) | 2001-08-30 | 2003-12-30 | Shirley Cheng Tsai | Multiple horn atomizer with high frequency capability |
DE10145479A1 (en) * | 2001-09-14 | 2003-05-08 | Trw Automotive Safety Sys Gmbh | Method for folding an airbag for a vehicle occupant restraint system and folded airbag |
US6776352B2 (en) * | 2001-11-26 | 2004-08-17 | Kimberly-Clark Worldwide, Inc. | Apparatus for controllably focusing ultrasonic acoustical energy within a liquid stream |
US6743463B2 (en) | 2002-03-28 | 2004-06-01 | Scimed Life Systems, Inc. | Method for spray-coating a medical device having a tubular wall such as a stent |
JP2003339729A (en) | 2002-05-22 | 2003-12-02 | Olympus Optical Co Ltd | Ultrasonic operation apparatus |
WO2004002367A1 (en) | 2002-06-27 | 2004-01-08 | Microport Medical (Shanghai) Co., Ltd. | Drug eluting stent |
US7160516B2 (en) * | 2002-07-30 | 2007-01-09 | Sonics & Materials, Inc. | High volume ultrasonic flow cell |
US6818063B1 (en) | 2002-09-24 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for minimizing coating defects |
DE602004018282D1 (en) | 2003-03-17 | 2009-01-22 | Ev3 Endovascular Inc | STENT WITH LAMINATED THIN FILM LINKAGE |
US7163555B2 (en) | 2003-04-08 | 2007-01-16 | Medtronic Vascular, Inc. | Drug-eluting stent for controlled drug delivery |
US20040215313A1 (en) | 2003-04-22 | 2004-10-28 | Peiwen Cheng | Stent with sandwich type coating |
US20040236399A1 (en) | 2003-04-22 | 2004-11-25 | Medtronic Vascular, Inc. | Stent with improved surface adhesion |
US8518097B2 (en) | 2003-04-25 | 2013-08-27 | Medtronic Vascular, Inc. | Plasticized stent coatings |
US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US7524527B2 (en) | 2003-05-19 | 2009-04-28 | Boston Scientific Scimed, Inc. | Electrostatic coating of a device |
US6883729B2 (en) | 2003-06-03 | 2005-04-26 | Archimedes Technology Group, Inc. | High frequency ultrasonic nebulizer for hot liquids |
US7169179B2 (en) | 2003-06-05 | 2007-01-30 | Conor Medsystems, Inc. | Drug delivery device and method for bi-directional drug delivery |
US20050058768A1 (en) | 2003-09-16 | 2005-03-17 | Eyal Teichman | Method for coating prosthetic stents |
US7060319B2 (en) | 2003-09-24 | 2006-06-13 | Boston Scientific Scimed, Inc. | method for using an ultrasonic nozzle to coat a medical appliance |
US7744645B2 (en) | 2003-09-29 | 2010-06-29 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent with dipped and cured layers |
US7318932B2 (en) | 2003-09-30 | 2008-01-15 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same |
US7896539B2 (en) * | 2005-08-16 | 2011-03-01 | Bacoustics, Llc | Ultrasound apparatus and methods for mixing liquids and coating stents |
US7810743B2 (en) | 2006-01-23 | 2010-10-12 | Kimberly-Clark Worldwide, Inc. | Ultrasonic liquid delivery device |
US7429815B2 (en) | 2006-06-23 | 2008-09-30 | Caterpillar Inc. | Fuel injector having encased piezo electric actuator |
US7780095B2 (en) * | 2007-07-13 | 2010-08-24 | Bacoustics, Llc | Ultrasound pumping apparatus |
US7896854B2 (en) * | 2007-07-13 | 2011-03-01 | Bacoustics, Llc | Method of treating wounds by creating a therapeutic solution with ultrasonic waves |
US8016208B2 (en) * | 2008-02-08 | 2011-09-13 | Bacoustics, Llc | Echoing ultrasound atomization and mixing system |
US7950594B2 (en) * | 2008-02-11 | 2011-05-31 | Bacoustics, Llc | Mechanical and ultrasound atomization and mixing system |
-
2005
- 2005-08-16 US US11/204,872 patent/US7896539B2/en active Active - Reinstated
-
2006
- 2006-07-18 CA CA002659974A patent/CA2659974A1/en not_active Abandoned
- 2006-07-18 AT AT06787746T patent/ATE460230T1/en not_active IP Right Cessation
- 2006-07-18 EP EP06787746A patent/EP1915218B1/en not_active Not-in-force
- 2006-07-18 KR KR1020087004252A patent/KR20080040728A/en not_active Application Discontinuation
- 2006-07-18 JP JP2008526940A patent/JP2009504396A/en active Pending
- 2006-07-18 WO PCT/US2006/027895 patent/WO2007021427A2/en active Application Filing
- 2006-07-18 DE DE602006012847T patent/DE602006012847D1/en active Active
- 2006-07-18 CN CNA2006800296818A patent/CN101242907A/en active Pending
-
2007
- 2007-12-17 US US11/957,557 patent/US20080091108A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1915218B1 (en) | 2010-03-10 |
DE602006012847D1 (en) | 2010-04-22 |
EP1915218A2 (en) | 2008-04-30 |
JP2009504396A (en) | 2009-02-05 |
ATE460230T1 (en) | 2010-03-15 |
EP1915218A4 (en) | 2008-09-03 |
WO2007021427A3 (en) | 2007-12-06 |
US7896539B2 (en) | 2011-03-01 |
CN101242907A (en) | 2008-08-13 |
US20080091108A1 (en) | 2008-04-17 |
US20070051307A1 (en) | 2007-03-08 |
WO2007021427A2 (en) | 2007-02-22 |
KR20080040728A (en) | 2008-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1915218B1 (en) | Ultrasound apparatus and methods for mixing liquids and coating stents | |
CA2659932A1 (en) | Ultrasound medical stent coating method and device | |
US7892593B2 (en) | Process for coating a substrate | |
US6979473B2 (en) | Method for fine bore orifice spray coating of medical devices and pre-filming atomization | |
EP1581278B1 (en) | Coating medical devices | |
US20070254091A1 (en) | System and method for electrostatic-assisted spray coating of a medical device | |
JP5517134B2 (en) | Ultrasonic atomization nozzle with variable fan jet function | |
US10105246B2 (en) | Hybrid polymer stent fabricated by a non-laser cut fabrication method | |
JP2008515611A (en) | Method of coating medical device using electrical infiltration method, system for using the method, and device manufactured by the method | |
US7691431B2 (en) | System and method for spray coating multiple medical devices using a rotary atomizer | |
US7531202B2 (en) | Nozzle and method for use in coating a stent | |
Berger | Coating drug-eluting arterial stents using ultrasonic spray nozzles | |
JP6621508B1 (en) | Method and apparatus for applying suction particulate coating | |
JP2023130567A (en) | atomization device | |
JP2013230457A (en) | Nozzle and liquid discharge system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |