CA2670156A1 - Air separator for extracorporeal fluid treatment sets - Google Patents
Air separator for extracorporeal fluid treatment sets Download PDFInfo
- Publication number
- CA2670156A1 CA2670156A1 CA002670156A CA2670156A CA2670156A1 CA 2670156 A1 CA2670156 A1 CA 2670156A1 CA 002670156 A CA002670156 A CA 002670156A CA 2670156 A CA2670156 A CA 2670156A CA 2670156 A1 CA2670156 A1 CA 2670156A1
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- CA
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- Prior art keywords
- chamber
- air separator
- separator according
- channel
- wall
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3638—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters with a vapour trap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
- A61M1/3641—Pressure isolators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/0042—Degasification of liquids modifying the liquid flow
Abstract
An air separator (1) comprises a first chamber (2) where blood or other fluid can be received, an inlet and an outlet port associated to the bottom wall (4) and in fluid communication with the first chamber. A first channel (14) extending along the lateral wall of the separator and has a first and a second portion (16 and 18). The channel second portion (18) terminally forms an orifice (15) facing the chamber and extending in an area closer to a top wall (5) of the chamber (2) than to the bottom wall of the same chamber. The orifice faces the top of the separator and has a flow passage cross section greater than that of a first portion (16) of the channel.
Claims (42)
1. Air separator (1) for extracorporeal fluid treatment sets comprising:
a first chamber (2) where fluid can be received, the first chamber presenting:
a bottom wall (4), a top wall (5), a lateral wall (6) extending between the top and bottom walls, an inlet port (10) and an outlet port (11) associated to the bottom wall and in fluid communication with the first chamber (2), a first channel (14) extending along at least a portion of the lateral wall (6) and having a first end (14a), connected to the inlet port (10), and a second end (14b) terminating in an orifice which is closer to said top wall (5) than to said bottom wall (4).
a first chamber (2) where fluid can be received, the first chamber presenting:
a bottom wall (4), a top wall (5), a lateral wall (6) extending between the top and bottom walls, an inlet port (10) and an outlet port (11) associated to the bottom wall and in fluid communication with the first chamber (2), a first channel (14) extending along at least a portion of the lateral wall (6) and having a first end (14a), connected to the inlet port (10), and a second end (14b) terminating in an orifice which is closer to said top wall (5) than to said bottom wall (4).
2. Air separator according to claim 1, wherein said first channel has a first portion (16) extending from the first end and at least a second portion (18) terminating in correspondence of the second end, the second portion (18) presenting a flow passage cross section greater then that of the first portion.
3. Air separator according to claim 2, wherein at least the second portion (18) has a continuously and progressively increasing flow passage cross section.
4. Air separator according to claim 2, wherein the flow passage cross section of the first portion (16) and the flow passage cross section of the second portion (18) are substantially constant.
5. Air separator according to claim 4, wherein said first channel (14) comprises a connection portion (17) extending between the second portion (18) and the first portion (14).
6. Air separator according to claim 5, wherein the connection portion has a progressively increasing flow passage cross section.
7. Air separator according to claim 5, wherein the connection portion comprises at least one aperture (23d) that puts into communication the first channel (14) directly with the first chamber (2).
8. Air separator according to anyone of the preceding claims, wherein the first portion and the second portion (16 and 18) extend in correspondence of and substantially parallel to the lateral wall (6) of the first chamber.
9. Air separator according to anyone of the preceding claims, wherein the first portion (16) is longer than the second portion (18).
10. Air separator according to anyone of the preceding claims, wherein the orifice (15) opens into the first chamber and faces said top wall.
11. Air separator according to claim 10, wherein said orifice (15) extends on a plane perpendicular to the lateral wall of the first chamber.
12. Air separator according to anyone of claims from 2 to 11, wherein a ratio A1/A3 is comprised between 1.5 and 2.5, where:
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A3 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of the first portion (16).
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A3 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of the first portion (16).
13. Air separator according to anyone of the preceding claims wherein a ratio D2/D1 is grater than 0.5 and for instance comprised between 0.55 and 0.70, where:
D1 represents the measure of the distance between top wall (5) inner surface of the first chamber (2) and bottom wall (4) inner surface of the first chamber, D2 represents the measure of the distance between the horizontal plane where the orifice (15) of the first channel extends and the bottom wall (4) inner surface of the first chamber.
D1 represents the measure of the distance between top wall (5) inner surface of the first chamber (2) and bottom wall (4) inner surface of the first chamber, D2 represents the measure of the distance between the horizontal plane where the orifice (15) of the first channel extends and the bottom wall (4) inner surface of the first chamber.
14. Air separator according to anyone of the preceding claims, wherein ratio A1/A2 is greater than 0.25 and less than 0.75, where:
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section horizontally aligned with the orifice.
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section horizontally aligned with the orifice.
15. Air separator according to anyone of the preceding claims, comprising a filter (19) engaged to the bottom wall in correspondence of the outlet port (11).
16. Air separator according to claim 15, wherein the filter (19) axially extends into the first chamber according to a direction substantially parallel to the first channel (14), this latter being parallel to lateral wall (6).
17. Air separator according to claim 16, wherein the filter (19) presents an overall axial extension substantially not grater than 70% of the measure of the distance between the horizontal plane where the orifice of the first channel extends and the bottom wall inner surface of the first chamber.
18. Air separator according to claim 17, wherein the filter (19) has an axial extension not greater that that of the first portion (16) of said first channel (14).
19. Air separator according to anyone of the preceding claims, wherein the first channel (14) and the first chamber (2) are made in one single plastic piece.
20. Air separator according to anyone of the preceding claims, wherein the air separator (1) has a flattened structure, said first channel (14) and said first chamber (2) having a substantially square shaped transverse section.
21. Air separator according to anyone of the preceding claims, wherein said lateral wall (6) presents:
a front wall, a rear wall spaced from the front wall, and side walls extending between said front and rear walls, said air separator comprising an intermediate (23) wall extending between the front and real walls and laterally delimiting said channel in cooperation with one of said side walls.
a front wall, a rear wall spaced from the front wall, and side walls extending between said front and rear walls, said air separator comprising an intermediate (23) wall extending between the front and real walls and laterally delimiting said channel in cooperation with one of said side walls.
22. Air separator according to claim 21, wherein said intermediate wall (23) presents a first wall portion (23a) parallel to said one side wall, a second wall portion (23b) parallel to the same side wall and a deflecting portion (23c) connecting said first and second portion thereby forming said first portion (16), said connection portion (17) and said second portion (18).
23. Air separator according to anyone of the preceding claims comprising:
a second chamber (3) positioned in side by side relationship with respect to said first chamber (2), said second chamber being delimited by respective bottom wall (7), top wall (8), and lateral wall (9) extending between the top and bottom walls, and being provided with respective inlet and outlet ports (12 and 13).
a second chamber (3) positioned in side by side relationship with respect to said first chamber (2), said second chamber being delimited by respective bottom wall (7), top wall (8), and lateral wall (9) extending between the top and bottom walls, and being provided with respective inlet and outlet ports (12 and 13).
24. Air separator according to claim 23, wherein said lateral wall of the second chamber presents:
a front wall, a rear wall spaced from the front wall, and side walls extending between said front and rear walls, said first and second chamber being in one single piece and sharing a common side wall (25) which extends in correspondence of a central zone of the air separator.
a front wall, a rear wall spaced from the front wall, and side walls extending between said front and rear walls, said first and second chamber being in one single piece and sharing a common side wall (25) which extends in correspondence of a central zone of the air separator.
25. Air separator according to claim 24, comprising a second channel (20) extending parallel to the lateral wall (9) of the second chamber (3) and having a first end (20a), connected to the inlet port, and a second end (20b) terminating into the second chamber, the second channel having constant cross section and presenting a deflector (21) in correspondence of its second end defining an orifice facing the lateral wall of the second chamber.
26. Air separator according to claim 25, wherein the orifice of the second channel is substantially at the same height as the orifice (15) of the first channel.
27. Air separator according to anyone of the preceding claims, wherein the lateral wall of said first chamber comprises pressure transducer means (24) and wherein said first channel ends immediately below said pressure transducer means.
28. Air separator according to claim 27, wherein the lateral wall of said second chamber comprises pressure transducer means (24) and wherein said second channel ends immediately below said pressure transducer means.
29. Air separator for extracorporeal fluid treatment sets comprising:
a first chamber (2) where fluid air can be received, the first chamber presenting:
a bottom wall (4), a top wall (5), a lateral wall (6) extending between the top and bottom walls, an inlet and an outlet port (10 and 11) associated to the bottom wall and in fluid communication with the first chamber, a first channel (14) having a first end, connected to the inlet port, and a second end terminating into the first chamber, a filter (19) engaged to the bottom wall in correspondence of the outlet port and axially extending into the first chamber according to a direction substantially parallel to the first channel, the filter presenting an overall axial extension which is not grater than 70% of the overall longitudinal extension of the first channel (14).
a first chamber (2) where fluid air can be received, the first chamber presenting:
a bottom wall (4), a top wall (5), a lateral wall (6) extending between the top and bottom walls, an inlet and an outlet port (10 and 11) associated to the bottom wall and in fluid communication with the first chamber, a first channel (14) having a first end, connected to the inlet port, and a second end terminating into the first chamber, a filter (19) engaged to the bottom wall in correspondence of the outlet port and axially extending into the first chamber according to a direction substantially parallel to the first channel, the filter presenting an overall axial extension which is not grater than 70% of the overall longitudinal extension of the first channel (14).
30. Air separator according to claim 29, wherein said first channel has a first portion (16) extending from the first end and at least a second portion (18) terminating in correspondence of the second end, the first portion presenting a flow passage cross section greater then that of the second portion.
31. Air separator according to claim 30, wherein the first portion (16) and the second portion (18) extend in correspondence of and substantially parallel to the lateral wall (6) of the first chamber, the flow passage cross section of the first portion and the flow passage cross section of the second portion being substantially constant.
32. Air separator according to claim 30, wherein the first portion (16) is longer than the second portion (18) and longer than the filter axial extension.
33. Air separator according to claim 30, wherein the second end of said first channel forms an orifice (15), which opens into the first chamber and extends on a plane perpendicular to the lateral wall of the first chamber.
34. Air separator according to claim 33, wherein a ratio A1/A3 is comprised between 1.5 and 2.5, where:
A1 represents the measure of the flow passage cross section area of the first channel in correspondence of said orifice (15), A3 represents the measure of the flow passage cross section area of the first channel in correspondence of the first portion (16).
A1 represents the measure of the flow passage cross section area of the first channel in correspondence of said orifice (15), A3 represents the measure of the flow passage cross section area of the first channel in correspondence of the first portion (16).
35. Air separator according to claim 33, wherein a ratio D2/D1 is grater than 0.5 and for instance comprised between 0.55 and 0.70, where:
D1 represents the measure of the distance between top wall (5) inner surface of the first chamber (2) and bottom wall (4) inner surface of the first chamber, D2 represents the measure of the distance between the horizontal plane where the orifice (15) of the first channel extends and the bottom wall (4) inner surface of the first chamber.
D1 represents the measure of the distance between top wall (5) inner surface of the first chamber (2) and bottom wall (4) inner surface of the first chamber, D2 represents the measure of the distance between the horizontal plane where the orifice (15) of the first channel extends and the bottom wall (4) inner surface of the first chamber.
36. Air separator according to claim 33, wherein ratio A1/A2 is greater than 0.25 and less than 0.75, where:
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section horizontally aligned with the orifice.
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section horizontally aligned with the orifice.
37. Air separator for extracorporeal fluid treatment sets comprising:
a first chamber (2) where fluid can be received, the first chamber presenting:
a bottom wall (4), a top wall (5), a lateral wall (6) extending between the top and bottom walls, an inlet and an outlet port (10 and 11) associated to the bottom wall and in fluid communication with the first chamber, a first channel (14) having a first portion (16) connected to the inlet port, and a second portion (18) terminating into an orifice (15), wherein the flow passage cross section of the first portion and the flow passage cross section of the second portion are substantially constant and the first portion flow passage cross section is greater then that of the second portion.
a first chamber (2) where fluid can be received, the first chamber presenting:
a bottom wall (4), a top wall (5), a lateral wall (6) extending between the top and bottom walls, an inlet and an outlet port (10 and 11) associated to the bottom wall and in fluid communication with the first chamber, a first channel (14) having a first portion (16) connected to the inlet port, and a second portion (18) terminating into an orifice (15), wherein the flow passage cross section of the first portion and the flow passage cross section of the second portion are substantially constant and the first portion flow passage cross section is greater then that of the second portion.
38. Air separator according to claim 37, wherein ratio A1/A2 is greater than 0.25 and less than 0.75, where:
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section horizontally aligned with the orifice.
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section horizontally aligned with the orifice.
39. Air separator according to claim 37, wherein a ratio D2/D1 is grater than 0.5 and for instance comprised between 0.55 and 0.70, where:
D1 represents the measure of the distance between top wall (5) inner surface of the first chamber (2) and bottom wall (4) inner surface of the first chamber, D2 represents the measure of the distance between the horizontal plane where the orifice (15) of the first channel extends and the bottom wall (4) inner surface of the first chamber (2).
D1 represents the measure of the distance between top wall (5) inner surface of the first chamber (2) and bottom wall (4) inner surface of the first chamber, D2 represents the measure of the distance between the horizontal plane where the orifice (15) of the first channel extends and the bottom wall (4) inner surface of the first chamber (2).
40. Air separator according to claim 37, wherein ratio A1/A2 is greater than 0.25 and less than 0.75, where:
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section aligned with the orifice (15).
A1 represents the measure of the flow passage cross section area of the first channel (14) in correspondence of said orifice (15), A2 represents the measure of the flow passage cross section area of the first chamber (2) in correspondence of a section aligned with the orifice (15).
41. Air separator according to anyone of the preceding claims, comprising at least one selected in the group including:
a venous line (73) which has at least one end designed to be connected to a patient and another end designed to be connected with a blood treatment unit, said venous line (73) including a first flexible tube (79) engaged to the inlet port of the first chamber, a second flexible tube (80) engaged to the outlet port of the first chamber, an arterial line (70) which as at least one end designed to be connected to a patient and another end designed to be connected with a blood treatment unit, said arterial line (70) including a third flexible tube (81) engaged to the inlet port of the second chamber, and a fourth flexible tube (82) engaged to the outlet port of the second chamber and to one wall of said second chamber for forming a loop (83) which is symmetric about a loop axis transverse to the lateral wall (9) of the second chamber.
a venous line (73) which has at least one end designed to be connected to a patient and another end designed to be connected with a blood treatment unit, said venous line (73) including a first flexible tube (79) engaged to the inlet port of the first chamber, a second flexible tube (80) engaged to the outlet port of the first chamber, an arterial line (70) which as at least one end designed to be connected to a patient and another end designed to be connected with a blood treatment unit, said arterial line (70) including a third flexible tube (81) engaged to the inlet port of the second chamber, and a fourth flexible tube (82) engaged to the outlet port of the second chamber and to one wall of said second chamber for forming a loop (83) which is symmetric about a loop axis transverse to the lateral wall (9) of the second chamber.
42. Blood treatment machine comprising:
a dialysis liquid preparation module for preparing dialysis liquid, at least a waste line for receiving spent dialysate, a blood treatment unit having a first chamber connected to dialysis liquid preparation module and to the waste line, and a second chamber separated from the first chamber by means of a semipermeable membrane, and the air separator of claim 41, wherein the arterial line (70) is connected an inlet of the second chamber and the venous line (73) is connected to an outlet of the second chamber.
a dialysis liquid preparation module for preparing dialysis liquid, at least a waste line for receiving spent dialysate, a blood treatment unit having a first chamber connected to dialysis liquid preparation module and to the waste line, and a second chamber separated from the first chamber by means of a semipermeable membrane, and the air separator of claim 41, wherein the arterial line (70) is connected an inlet of the second chamber and the venous line (73) is connected to an outlet of the second chamber.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2753895A CA2753895C (en) | 2006-10-30 | 2006-10-30 | Air separator for extracorporeal fluid treatment sets |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/003038 WO2008053261A1 (en) | 2006-10-30 | 2006-10-30 | Air separator for extracorporeal fluid treatment sets |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2753895A Division CA2753895C (en) | 2006-10-30 | 2006-10-30 | Air separator for extracorporeal fluid treatment sets |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2670156A1 true CA2670156A1 (en) | 2008-05-08 |
CA2670156C CA2670156C (en) | 2011-12-20 |
Family
ID=38191119
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2670156A Active CA2670156C (en) | 2006-10-30 | 2006-10-30 | Air separator for extracorporeal fluid treatment sets |
CA2753895A Active CA2753895C (en) | 2006-10-30 | 2006-10-30 | Air separator for extracorporeal fluid treatment sets |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2753895A Active CA2753895C (en) | 2006-10-30 | 2006-10-30 | Air separator for extracorporeal fluid treatment sets |
Country Status (10)
Country | Link |
---|---|
US (2) | US8747342B2 (en) |
EP (2) | EP2407191B1 (en) |
KR (1) | KR101066506B1 (en) |
CN (1) | CN101534879B (en) |
AT (1) | ATE534418T1 (en) |
AU (2) | AU2006350461B2 (en) |
CA (2) | CA2670156C (en) |
ES (2) | ES2375210T3 (en) |
PL (2) | PL2407191T3 (en) |
WO (1) | WO2008053261A1 (en) |
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-
2006
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Also Published As
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CA2670156C (en) | 2011-12-20 |
EP2407191B1 (en) | 2012-12-12 |
CA2753895C (en) | 2013-12-10 |
US20100292627A1 (en) | 2010-11-18 |
CN101534879B (en) | 2012-07-25 |
EP2407191A1 (en) | 2012-01-18 |
AU2006350461A1 (en) | 2008-05-08 |
AU2011200545A1 (en) | 2011-03-03 |
KR101066506B1 (en) | 2011-09-21 |
WO2008053261A1 (en) | 2008-05-08 |
EP2081620A1 (en) | 2009-07-29 |
PL2081620T3 (en) | 2012-04-30 |
AU2011200545B2 (en) | 2012-04-26 |
CA2753895A1 (en) | 2008-05-08 |
AU2006350461B2 (en) | 2010-11-11 |
ATE534418T1 (en) | 2011-12-15 |
EP2081620B1 (en) | 2011-11-23 |
PL2407191T3 (en) | 2013-05-31 |
US20140230657A1 (en) | 2014-08-21 |
ES2401073T3 (en) | 2013-04-16 |
CN101534879A (en) | 2009-09-16 |
KR20090086997A (en) | 2009-08-14 |
ES2375210T3 (en) | 2012-02-27 |
US8747342B2 (en) | 2014-06-10 |
US10010665B2 (en) | 2018-07-03 |
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