CA2677606A1 - Clay-based hemostatic agents and devices for the delivery thereof - Google Patents
Clay-based hemostatic agents and devices for the delivery thereof Download PDFInfo
- Publication number
- CA2677606A1 CA2677606A1 CA002677606A CA2677606A CA2677606A1 CA 2677606 A1 CA2677606 A1 CA 2677606A1 CA 002677606 A CA002677606 A CA 002677606A CA 2677606 A CA2677606 A CA 2677606A CA 2677606 A1 CA2677606 A1 CA 2677606A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- hemostatic
- substrate
- clay
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000004927 clay Substances 0.000 title claims abstract 34
- 229940030225 antihemorrhagics Drugs 0.000 title 1
- 239000002874 hemostatic agent Substances 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract 51
- 239000000463 material Substances 0.000 claims abstract 47
- 239000000758 substrate Substances 0.000 claims abstract 32
- 230000002439 hemostatic effect Effects 0.000 claims abstract 29
- 229920005862 polyol Polymers 0.000 claims abstract 22
- 150000003077 polyols Chemical class 0.000 claims abstract 22
- 230000000740 bleeding effect Effects 0.000 claims abstract 10
- 239000008280 blood Substances 0.000 claims abstract 7
- 210000004369 blood Anatomy 0.000 claims abstract 7
- 239000006185 dispersion Substances 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 claims 8
- 239000005995 Aluminium silicate Substances 0.000 claims 7
- 235000012211 aluminium silicate Nutrition 0.000 claims 7
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 4
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 claims 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 4
- 229920002472 Starch Polymers 0.000 claims 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 4
- 229960000892 attapulgite Drugs 0.000 claims 4
- 239000000440 bentonite Substances 0.000 claims 4
- 229910000278 bentonite Inorganic materials 0.000 claims 4
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 4
- 229940043353 maltol Drugs 0.000 claims 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229910052625 palygorskite Inorganic materials 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 229920001296 polysiloxane Polymers 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 235000013772 propylene glycol Nutrition 0.000 claims 4
- 239000000600 sorbitol Substances 0.000 claims 4
- 229960002920 sorbitol Drugs 0.000 claims 4
- 239000008107 starch Substances 0.000 claims 4
- 235000019698 starch Nutrition 0.000 claims 4
- 239000000811 xylitol Substances 0.000 claims 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 4
- 229960002675 xylitol Drugs 0.000 claims 4
- 235000010447 xylitol Nutrition 0.000 claims 4
- 239000005909 Kieselgur Substances 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- -1 silver ions Chemical class 0.000 claims 3
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
- 239000004375 Dextrin Substances 0.000 claims 2
- 229920001353 Dextrin Polymers 0.000 claims 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 229940035676 analgesics Drugs 0.000 claims 2
- 239000000730 antalgic agent Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- 239000003429 antifungal agent Substances 0.000 claims 2
- 239000000739 antihistaminic agent Substances 0.000 claims 2
- 229940125715 antihistaminic agent Drugs 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 239000005313 bioactive glass Substances 0.000 claims 2
- 239000001110 calcium chloride Substances 0.000 claims 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims 2
- 235000011148 calcium chloride Nutrition 0.000 claims 2
- 235000019425 dextrin Nutrition 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 2
- 235000019341 magnesium sulphate Nutrition 0.000 claims 2
- 229910052709 silver Inorganic materials 0.000 claims 2
- 239000004332 silver Substances 0.000 claims 2
- 235000019983 sodium metaphosphate Nutrition 0.000 claims 2
- 229920000742 Cotton Polymers 0.000 claims 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims 1
- 229920001100 Polydextrose Polymers 0.000 claims 1
- 229920000297 Rayon Polymers 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 229910001431 copper ion Inorganic materials 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 239000001259 polydextrose Substances 0.000 claims 1
- 235000013856 polydextrose Nutrition 0.000 claims 1
- 229940035035 polydextrose Drugs 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 239000002964 rayon Substances 0.000 claims 1
- 210000002268 wool Anatomy 0.000 claims 1
- 206010053567 Coagulopathies Diseases 0.000 abstract 3
- 230000035602 clotting Effects 0.000 abstract 3
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A61F13/01012—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/16—Materials with shape-memory or superelastic properties
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Abstract
A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
Claims (43)
1. A device capable of providing a hemostatic effect on a bleeding wound, said device comprising:
a gauze substrate;
a clay material disposed on said gauze substrate; and a polyol disposed on said gauze substrate to bind said clay material;
wherein when treating a bleeding wound, application of said device causes at least a portion of said clay material to come into contact with blood.
a gauze substrate;
a clay material disposed on said gauze substrate; and a polyol disposed on said gauze substrate to bind said clay material;
wherein when treating a bleeding wound, application of said device causes at least a portion of said clay material to come into contact with blood.
2. The device of claim 1, wherein said clay material is kaolin.
3. The device of claim 1, wherein said clay material is selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the foregoing materials.
4. The device of claim 1, further comprising diatomaceous earth disposed on said gauze substrate.
5. The device of claim 1, wherein said clay material further comprises a material selected from the group consisting of magnesium sulfate, sodium metaphosphate, calcium chloride, dextrin, hydrates of the foregoing materials, and combinations of the foregoing materials.
6. The device of claim 1, wherein said clay material further comprises a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions.
7. The device of claim 1, wherein said gauze substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing.
8. The device of claim 1, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound.
9. The device of claim 1, wherein said clay material is dispersed in said polyol and disposed on said substrate.
10. The device of claim 1, further comprising a release agent disposed on said clay material.
11. The device of claim 10, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch.
12. The device of claim 10, wherein said release agent is a film formed over said clay material.
13. The device of claim 1, wherein said clay material comprises particles having diameters of about 0.2 mm to about 10 mm.
14. The device claim 1, wherein said clay material comprises particles having diameters of about 1 mm to about 7 mm.
15. The device of claim 1, wherein said clay material comprises particles having diameters of about 2 mm to about 5 mm.
16. The device of claim 1, wherein said clay material comprises particles having diameters of less than 0.2 mm.
17. The device of claim 1, wherein said polyol is selected from the group consisting of glycerol, glycerol-based compounds, sorbitol, xylitol, maltol, polymeric polyols, and combinations of the foregoing.
18. The device of claim 17, wherein said polymeric polyol is polydextrose.
19. The device of claim 17, wherein said glycerol-based compound is selected from the group consisting of propylene glycols, glyceryl triacetates, and combinations of the foregoing.
20. A bandage applicable to a bleeding wound, said bandage comprising:
a flexible substrate;
a gauze substrate mounted on said flexible substrate;
a clay material disposed on said gauze substrate; and a polyol disposed on said gauze substrate to bind said clay material;
wherein when treating a bleeding wound, application of said bandage causes at least a portion of said clay material to come into contact with blood.
a flexible substrate;
a gauze substrate mounted on said flexible substrate;
a clay material disposed on said gauze substrate; and a polyol disposed on said gauze substrate to bind said clay material;
wherein when treating a bleeding wound, application of said bandage causes at least a portion of said clay material to come into contact with blood.
21. The bandage of claim 20, wherein said clay material is kaolin.
22. The bandage of claim 20, wherein said clay material is selected from the group consisting of attapulgite, bentonite, kaolin, and combinations of the foregoing materials.
23. The bandage of claim 20, wherein said clay material further comprises a material selected from the group consisting of magnesium sulfate, sodium metaphosphate, calcium chloride, dextrin, hydrates of the foregoing materials, and combinations of the foregoing materials.
24. The bandage of claim 20, wherein said clay material further comprises a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver ions, and combinations of the foregoing compositions.
25. The bandage of claim 20, further comprising an adhesive on said substrate, said adhesive being configured to facilitate the retaining of said bandage on the skin of a wearer.
26. The bandage of claim 20, wherein said clay material is dispersed in said polyol and disposed on said gauze substrate.
27. The bandage of claim 20, wherein said polyol is selected from the group consisting of glycerol, glycerol-based compounds, sorbitol, xylitol, maltol, polymeric polyols, and combinations of the foregoing.
28. The bandage of claim 27, wherein said glycerol-based compound is selected from the group consisting of propylene glycols, glyceryl triacetates, and combinations of the foregoing.
29. The bandage of claim 20, further comprising a release agent disposed over said clay material and said polyol disposed on said gauze substrate.
30. The bandage of claim 29, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch.
31. A hemostatic sponge, comprising:
a gauze substrate having a first surface; and a dispersion of a hemostatic material and a polyol disposed on said first surface of said gauze substrate;
wherein when treating a bleeding wound, application of said hemostatic sponge causes at least a portion of said hemostatic material to come into contact with blood.
a gauze substrate having a first surface; and a dispersion of a hemostatic material and a polyol disposed on said first surface of said gauze substrate;
wherein when treating a bleeding wound, application of said hemostatic sponge causes at least a portion of said hemostatic material to come into contact with blood.
32. The hemostatic sponge of claim 31, further comprising a release agent disposed on at least one of said gauze substrate and said dispersion of hemostatic material and polyol.
33. The hemostatic sponge of claim 31, wherein said hemostatic material is kaolin.
34. The hemostatic sponge of claim 31, wherein said hemostatic material is selected from the group consisting of attapulgite clay, bentonite clay, kaolin clay, bioactive glass, biological hemostats, diatomaceous earth, and combinations of the foregoing.
35. The hemostatic sponge of claim 32, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch.
36. The hemostatic sponge of claim 31, wherein said polyol is selected from the group consisting of glycerol, glycerol-based compounds, sorbitol, xylitol, maltol, polymeric polyols, and combinations of the foregoing.
37. The hemostatic sponge of claim 36, wherein said glycerol-based compound is selected from the group consisting of propylene glycols, glyceryl triacetates, and combinations of the foregoing.
38. A hemostatic sponge, comprising:
a first substrate;
a hemostatic material dispersed in a polyol and applied to said first substrate; and a second substrate disposed on said hemostatic material dispersed in said polyol;
wherein when treating a bleeding wound, application of said hemostatic sponge causes at least a portion of said hemostatic material to come into contact with blood through at least one of said first substrate and said second substrate.
a first substrate;
a hemostatic material dispersed in a polyol and applied to said first substrate; and a second substrate disposed on said hemostatic material dispersed in said polyol;
wherein when treating a bleeding wound, application of said hemostatic sponge causes at least a portion of said hemostatic material to come into contact with blood through at least one of said first substrate and said second substrate.
39. The hemostatic sponge of claim 38, wherein said hemostatic material is selected from the group consisting of attapulgite clay, bentonite clay, kaolin clay, bioactive glass, biological hemostats, diatomaceous earth, and combinations of the foregoing.
40. The hemostatic sponge of claim 38, further comprising a release agent disposed on said hemostatic material dispersed in said polyol.
41. The hemostatic sponge of claim 40, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch.
42. The hemostatic sponge of claim 38, wherein said polyol is selected from the group consisting of glycerol, glycerol-based compounds, sorbitol, xylitol, maltol, polymeric polyols, and combinations of the foregoing.
43. The hemostatic sponge of claim 42, wherein said glycerol-based compound is selected from the group consisting of propylene glycols, glyceryl triacetates, and combinations of the foregoing.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/715,057 | 2007-03-06 | ||
US11/715,057 US7604819B2 (en) | 2006-05-26 | 2007-03-06 | Clay-based hemostatic agents and devices for the delivery thereof |
PCT/US2008/003082 WO2008109160A2 (en) | 2007-03-06 | 2008-03-06 | Clay-based hemostatic agents and devices for the delivery thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112451213A (en) * | 2020-11-24 | 2021-03-09 | 江西美宝利医用敷料有限公司 | Antibacterial hemostatic gauze |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10105259B2 (en) | 2000-09-15 | 2018-10-23 | Bruder Healthcare Company, Llc | Wound and therapy compress and dressing |
ATE460146T1 (en) | 2000-09-15 | 2010-03-15 | Bruder Healthcare Co | WOUND AND TREATMENT COMPRESS AND DRESSING |
US9925087B2 (en) | 2000-09-15 | 2018-03-27 | Bruder Healthcare Company, Llc | Wound and therapy compress and dressing |
EP1667623B1 (en) * | 2003-09-12 | 2010-11-24 | Z-Medica Corporation | Partially hydrated hemostatic agent |
KR100561646B1 (en) * | 2003-10-23 | 2006-03-20 | 엘지.필립스 엘시디 주식회사 | Thin Film Transistor Substrate for Display Device And Method For Fabricating The Same |
US20060178609A1 (en) | 2005-02-09 | 2006-08-10 | Z-Medica, Llc | Devices and methods for the delivery of molecular sieve materials for the formation of blood clots |
EP1853326B1 (en) | 2005-02-15 | 2016-06-15 | Virginia Commonwealth University | Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
US8938898B2 (en) | 2006-04-27 | 2015-01-27 | Z-Medica, Llc | Devices for the identification of medical products |
US7604819B2 (en) | 2006-05-26 | 2009-10-20 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US7968114B2 (en) | 2006-05-26 | 2011-06-28 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US8202532B2 (en) | 2006-05-26 | 2012-06-19 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US20080319476A1 (en) * | 2007-05-22 | 2008-12-25 | Ward Kevin R | Hemostatic mineral compositions and uses thereof |
WO2008157536A2 (en) * | 2007-06-21 | 2008-12-24 | Z-Medica Corporation | Hemostatic sponge and method of making the same |
JP6134933B2 (en) * | 2009-01-27 | 2017-05-31 | レッドドレス リミテッド | Wound dressing, method and device for making the same, and storage and use thereof |
CN101869721A (en) * | 2010-05-28 | 2010-10-27 | 张胜民 | Clay-enhanced cuttlefish bone meal hemostatic gauze and manufacturing method thereof |
US8858969B2 (en) | 2010-09-22 | 2014-10-14 | Z-Medica, Llc | Hemostatic compositions, devices, and methods |
CN102274541A (en) * | 2011-09-09 | 2011-12-14 | 天津禹王生物医药科技有限公司 | Hemostatic material |
US9408913B2 (en) | 2011-09-12 | 2016-08-09 | Protege Biomedical, Llc | Composition and dressing for wound treatment |
WO2013048787A1 (en) | 2011-09-26 | 2013-04-04 | Yes, Inc. | Novel hemostatic compositions and dressings for bleeding |
WO2013052577A1 (en) * | 2011-10-04 | 2013-04-11 | Z-Medica, Llc | Hemostatic fibrous material |
WO2013056116A1 (en) * | 2011-10-12 | 2013-04-18 | The Trustees Of Columbia University In The City Of New York | Hemostatic dressing for arterial bleeding |
BR112014031439A8 (en) * | 2012-06-22 | 2023-01-31 | Z Medica Llc | HEMOSTATIC AND WOUND DEVICES AND DRESSINGS AND PROCESSES FOR PRODUCING HEMOSTATIC AND WOUND DEVICE |
US10016527B2 (en) | 2012-10-23 | 2018-07-10 | Orthovita, Inc. | Materials and methods for repair of cartilage defects |
US11007143B2 (en) | 2013-03-15 | 2021-05-18 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body |
US10398733B2 (en) | 2013-03-15 | 2019-09-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body |
US11000545B2 (en) | 2013-03-15 | 2021-05-11 | Cda Research Group, Inc. | Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza |
US11083750B2 (en) | 2013-03-15 | 2021-08-10 | Cda Research Group, Inc. | Methods of treatment using topical copper ion formulations |
US11318089B2 (en) | 2013-03-15 | 2022-05-03 | Cda Research Group, Inc. | Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body |
WO2014143139A1 (en) | 2013-03-15 | 2014-09-18 | Bruder Healthcare Company | Wound and therapy compress and dressing |
CN104469280A (en) * | 2013-09-23 | 2015-03-25 | 国家电网公司 | Video monitoring device |
WO2015187103A1 (en) * | 2014-05-21 | 2015-12-10 | Punyanitya Sittiporn | Surgical hemostatic based rice starch |
MX2017010458A (en) | 2015-02-16 | 2018-04-24 | Andriyovych Manoryk Petro | Hemostatic composition and hemostatic device (variants). |
CN106033038A (en) * | 2015-03-12 | 2016-10-19 | 青岛易邦生物工程有限公司 | A method of processing serum used for avian infectious bronchitis hemagglutination inhibition assays |
JP2016198170A (en) * | 2015-04-08 | 2016-12-01 | 国立大学法人 鹿児島大学 | Wound covering material, and production method of wound covering material |
CN106540305A (en) * | 2015-09-17 | 2017-03-29 | 珠海和凡医药股份有限公司 | A kind of preparation of Kaolin bamboo fibre gauze and its new application |
USD844795S1 (en) | 2016-11-30 | 2019-04-02 | Bruder Healthcare Company, Llc | Therapeutic eye mask |
USD871598S1 (en) | 2016-11-30 | 2019-12-31 | Bruder Healthcare Company, Llc | Therapeutic eye mask |
US11254061B2 (en) | 2017-01-06 | 2022-02-22 | Ethicon, Inc. | Scaffolds for implanting absorbable hemostats in field conditions |
MX2019010663A (en) * | 2017-03-08 | 2019-12-02 | Baxter Int | Device for delivery of powdered hemostatic agents. |
JP6875170B2 (en) * | 2017-03-29 | 2021-05-19 | テルモ株式会社 | Hemostatic device |
CN109381733A (en) * | 2017-08-04 | 2019-02-26 | 天津工业大学 | A kind of controllable kaolin of surface roughness/Calcium alginate film hemostatic and antibacterial dressing preparation method |
CN109847092B (en) | 2018-06-18 | 2020-03-31 | 浙江大学 | Hemostatic compound and preparation method thereof |
CN109851858B (en) | 2018-06-18 | 2020-12-08 | 浙江大学 | Molecular sieve/fiber composite material and preparation method thereof |
CN108837174A (en) * | 2018-07-22 | 2018-11-20 | 熊振 | A kind of preparation method of medical dressing |
CN111249516B (en) | 2018-12-01 | 2020-12-22 | 浙江大学 | Trypsin-containing hemostatic fabric and preparation method thereof |
CN111249518B (en) | 2018-12-01 | 2021-03-05 | 浙江大学 | Hemostatic composition and preparation method thereof |
CN109646707A (en) * | 2018-12-14 | 2019-04-19 | 广州润虹医药科技股份有限公司 | A kind of rapid hemostatic material and preparation method thereof |
US11193184B2 (en) | 2019-02-22 | 2021-12-07 | Cda Research Group, Inc. | System for use in producing a metal ion suspension and process of using same |
CN110897671A (en) * | 2019-12-20 | 2020-03-24 | 中国人民解放军陆军特色医学中心 | Ventilated nasal cavity hemostatic device |
US20230158202A1 (en) * | 2019-12-26 | 2023-05-25 | Artisan Lab Co., Ltd. | Method for producing local hemostasis material, and local hemostasis material |
CN111228562B (en) * | 2020-03-26 | 2022-03-15 | 江苏德威兰医疗器械股份有限公司 | Starch hemostatic sponge and preparation method and application thereof |
CN111603605B (en) * | 2020-06-22 | 2022-06-21 | 湘潭大学 | Inorganic rapid hemostatic material and preparation method thereof |
CN112900095A (en) * | 2021-01-29 | 2021-06-04 | 明光市铭垚凹凸棒产业科技有限公司 | Composite gauze and preparation method and application thereof |
US20220323634A1 (en) * | 2021-04-06 | 2022-10-13 | The United States Of America, As Represented By The Secretary Of Agriculture | Fabric compositions comprising attached zeolite and/or a zeolite/pectin complex |
CN113908325B (en) * | 2021-09-24 | 2023-01-17 | 中山大学 | Low-adhesion blood loss-resistant hemostatic material and preparation method and application thereof |
CN115463242B (en) * | 2022-09-27 | 2023-09-08 | 中国地质大学(武汉) | Kaolin hemostatic gauze and preparation method thereof |
Family Cites Families (294)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB548046A (en) * | 1941-02-19 | 1942-09-23 | Walter Sim Harris | Improvements in or relating to lint, bandages, gauze, cotton wool and other surgicaldressings and bindings |
US2688586A (en) | 1950-03-17 | 1954-09-07 | Johnson & Johnson | Improved hemostatic alginic surgical dressings and method of making |
US2969145A (en) | 1956-05-07 | 1961-01-24 | Johnson & Johnson | Packaged adhesive bandage |
US2922719A (en) | 1957-04-08 | 1960-01-26 | Zonolite Company | Structural clay products and method of making the same |
US2989145A (en) * | 1957-12-20 | 1961-06-20 | Metal Textile Corp | Expanded sheet material |
US3122140A (en) | 1962-03-29 | 1964-02-25 | Johnson & Johnson | Flexible absorbent sheet |
US3189227A (en) * | 1962-12-07 | 1965-06-15 | American Home Prod | Fluid dispenser |
US3181231A (en) | 1963-08-06 | 1965-05-04 | Union Carbide Corp | Molecular sieve-metal agglomerates and their preparation |
US3366578A (en) | 1964-12-07 | 1968-01-30 | Universal Oil Prod Co | Zeolite and method for making the improved zeolite |
GB1155440A (en) * | 1966-01-18 | 1969-06-18 | Herman Ferdinand Kamp | Therapeutic Composition for Treating Skin Injuries |
US3550593A (en) | 1967-02-02 | 1970-12-29 | Jack W Kaufman | Therapeutic apparatus |
US3386802A (en) * | 1967-07-28 | 1968-06-04 | Universal Oil Prod Co | Method for preparing spherically-shaped crystalline zeolite particles |
US3538508A (en) | 1968-08-08 | 1970-11-10 | Samuel Young | Combination pillow and crash helmet |
FR2047874A6 (en) | 1969-06-10 | 1971-03-19 | Nouvel Lucien | |
US3723352A (en) | 1971-01-25 | 1973-03-27 | Air Prod & Chem | Supported silver catalysts |
US3698392A (en) | 1971-04-21 | 1972-10-17 | Kewanee Oil Co | Topical dressing |
US3763900A (en) | 1971-09-10 | 1973-10-09 | Milchwirlschaftliche Forschung | Process for sterilizing and filling aerosol containers |
US3979335A (en) | 1974-12-27 | 1976-09-07 | Georgy Anatolievich Golovko | Process for the preparation of synthetic zeolites |
JPS5792574A (en) * | 1980-11-28 | 1982-06-09 | Nippon Denso Co | Manufacture of cordierite ceramics |
US4379143A (en) | 1980-12-05 | 1983-04-05 | Pq Corporation | Topical liquid or ointment |
US4374044A (en) | 1981-01-19 | 1983-02-15 | General Motors Corporation | Cordierite bead catalyst support and method of preparation |
US4460642A (en) | 1981-06-26 | 1984-07-17 | Minnesota Mining And Manufacturing Company | Water-swellable composite sheet of microfibers of PTFE and hydrophilic absorptive particles |
US4373519A (en) | 1981-06-26 | 1983-02-15 | Minnesota Mining And Manufacturing Company | Composite wound dressing |
JPS58206751A (en) * | 1982-05-26 | 1983-12-02 | 日石三菱株式会社 | Wound covering material |
JPS5937956A (en) | 1982-08-24 | 1984-03-01 | カネボウ株式会社 | Particle filled fiber structure |
JPS5962050A (en) | 1982-09-30 | 1984-04-09 | 日本バイリ−ン株式会社 | Skin adhering agent |
JPS5962050U (en) | 1982-10-20 | 1984-04-23 | ナイルス部品株式会社 | Retractable headlamp control device |
JPS59133235A (en) | 1983-01-21 | 1984-07-31 | Kanebo Ltd | Zeolite particle-containing polymer and its production |
US4828832A (en) | 1983-09-07 | 1989-05-09 | Laboratorios Biochemie De Mexico | Method of manufacturing a composition for treating skin lesions |
US4514510A (en) | 1983-09-08 | 1985-04-30 | American Colloid Company | Hydrogen enriched water swellable clay having reduced acid demand and stable at low pH |
NZ209534A (en) | 1983-09-30 | 1987-01-23 | Surgikos Inc | Antimicrobial fabric for surgical drape |
US4822349A (en) | 1984-04-25 | 1989-04-18 | Hursey Francis X | Method of treating wounds |
US4748978A (en) | 1984-09-27 | 1988-06-07 | Kamp Herman F | Therapeutic dressing having mineral components |
DK158066C (en) | 1984-11-21 | 1990-08-20 | Moelnlycke Ab | FIXING BIND |
JPH0245040Y2 (en) | 1984-11-21 | 1990-11-29 | ||
US4651410A (en) * | 1984-12-18 | 1987-03-24 | Semiconductor Division Thomson-Csf Components Corporation | Method of fabricating regions of a bipolar microwave integratable transistor |
JPS61145120A (en) | 1984-12-20 | 1986-07-02 | Sofuto Shirika Kk | Maturative for affected part of trauma |
US4626550A (en) | 1985-01-14 | 1986-12-02 | Pq Corporation | Zeolite for personal care products |
JPS61145120U (en) | 1985-02-28 | 1986-09-08 | ||
JPS61240963A (en) * | 1985-04-18 | 1986-10-27 | ユニチカ株式会社 | Wound covering protective material |
US4631845A (en) | 1985-05-17 | 1986-12-30 | Intermec Corporation | Luggage tag |
GB2175889A (en) | 1985-05-23 | 1986-12-10 | Nat Res Dev | Clay films and applications |
US4717735A (en) | 1986-04-10 | 1988-01-05 | European Body Wrap, Inc. | Composition for body wrap |
US5599578A (en) | 1986-04-30 | 1997-02-04 | Butland; Charles L. | Technique for labeling an object for its identification and/or verification |
US4728323A (en) | 1986-07-24 | 1988-03-01 | Minnesota Mining And Manufacturing Company | Antimicrobial wound dressings |
US4938958A (en) | 1986-12-05 | 1990-07-03 | Shinagawa Fuel Co., Ltd. | Antibiotic zeolite |
US4761324B1 (en) | 1987-06-24 | 1991-05-07 | Elastic,laminated,water-proof,moisture-permeable fabric | |
JPH0618899B2 (en) | 1987-06-30 | 1994-03-16 | 品川燃料株式会社 | Film containing antibacterial zeolite |
JP2532515B2 (en) | 1987-10-08 | 1996-09-11 | 水澤化学工業株式会社 | Blood coagulant |
JPH0196558U (en) | 1987-12-18 | 1989-06-27 | ||
US4828081A (en) | 1988-03-04 | 1989-05-09 | Samsonite Corporation | Luggage identification system |
JPH0245040A (en) | 1988-08-03 | 1990-02-15 | Terumo Corp | Reduced pressure blood taking tube |
US4956350A (en) * | 1988-08-18 | 1990-09-11 | Minnesota Mining And Manufacturing Company | Wound filling compositions |
CN1047976A (en) * | 1989-06-12 | 1990-12-26 | 湖南省衡阳卫生材料厂 | A kind of improvement of hemostatic gauze production method |
US5140949A (en) | 1989-09-19 | 1992-08-25 | Mobil Oil Corporation | Zeolite-clay composition and uses thereof |
US5271943A (en) | 1989-10-27 | 1993-12-21 | Scott Health Care | Wound gel compositions containing sodium chloride and method of using them |
NO171069C (en) | 1990-05-29 | 1993-01-20 | Protan Biopolymer As | COVALENT CIRCUIT, STRONGLY SWELLING ALKALIMETAL AND AMMONIUM ALGINATE GELS, AND PROCEDURES FOR PREPARING THEREOF |
JP2777279B2 (en) | 1990-10-08 | 1998-07-16 | 工業技術院長 | Wound dressing and method for producing the same |
US5146932A (en) | 1990-11-01 | 1992-09-15 | Mccabe Francis J | Elastic counterpressure garment |
GB9109367D0 (en) | 1991-05-01 | 1991-06-26 | Merck Sharp & Dohme | Surgical dressing |
US5575995A (en) | 1991-08-15 | 1996-11-19 | Giovanoni; Richard L. | Ferric subsulfate gel and methods of using same |
GB2259858A (en) | 1991-08-21 | 1993-03-31 | Glanmor Thomas Williams | Odour adsorbing means |
GB9212303D0 (en) | 1992-06-10 | 1992-07-22 | Johnson & Johnson Medical Ltd | Absorbent products |
US5474545A (en) | 1992-12-07 | 1995-12-12 | Chikazawa; Osamu | Diaper and/or sanitary napkin |
GB9218749D0 (en) | 1992-09-04 | 1992-10-21 | Courtaulds Plc | Alginate gels |
DE4322956C2 (en) * | 1993-07-09 | 1995-12-21 | Haack Karl Werner An | Chitosan film for wound sealing |
US5486195A (en) | 1993-07-26 | 1996-01-23 | Myers; Gene | Method and apparatus for arteriotomy closure |
US5725551A (en) | 1993-07-26 | 1998-03-10 | Myers; Gene | Method and apparatus for arteriotomy closure |
GB9317180D0 (en) | 1993-08-18 | 1993-10-06 | Unilever Plc | Granular detergent compositions containing zeolite and process for their preparation |
WO1995012371A1 (en) | 1993-11-03 | 1995-05-11 | Clarion Pharmaceuticals, Inc. | Hemostatic patch |
US5502042A (en) | 1994-07-22 | 1996-03-26 | United States Surgical Corporation | Methods and compositions for treating wounds |
JPH0877746A (en) | 1994-08-31 | 1996-03-22 | Sony Corp | Recording medium housing cassette and cassette keeping case and label adhered thereto |
DE69534647T2 (en) | 1994-09-19 | 2006-07-27 | Sekisui Kagaku Kogyo K.K. | CONTAINERS AND CARRIER FOR THE BLOOD TEST CONTAINING A BLOOD COMPONENT ADHESION INHIBITOR |
EP0797395A4 (en) | 1994-11-28 | 1998-10-07 | John D Langley | A breathable non-woven composite fabric |
US5826543A (en) | 1995-01-20 | 1998-10-27 | Ralston Purina Company | Clumpable animal litter containing a dust reducing agent |
US5538500A (en) | 1995-02-08 | 1996-07-23 | Peterson; Donald A. | Postoperative wound dressing |
US5801116A (en) * | 1995-04-07 | 1998-09-01 | Rhodia Inc. | Process for producing polysaccharides and their use as absorbent materials |
FR2732585B1 (en) * | 1995-04-10 | 1997-10-17 | Garconnet Michel | COMPACT LOST PACKAGE FOR FIRST AID DRESSING |
US5578022A (en) * | 1995-04-12 | 1996-11-26 | Scherson; Daniel A. | Oxygen producing bandage and method |
US5788682A (en) | 1995-04-28 | 1998-08-04 | Maget; Henri J.R. | Apparatus and method for controlling oxygen concentration in the vicinity of a wound |
GB9510226D0 (en) | 1995-05-20 | 1995-07-19 | Smith & Nephew | Sterilisable cream or paste product for topical application |
EP1444991A1 (en) | 1995-06-07 | 2004-08-11 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
GB2305993A (en) | 1995-10-03 | 1997-04-23 | British Nuclear Fuels Plc | An energy storage rotor with axial length compensating means |
AUPN851996A0 (en) * | 1996-03-07 | 1996-03-28 | John Patrick Gray | Improvements in wound care management |
US5696101A (en) | 1996-04-16 | 1997-12-09 | Eastman Chemical Company | Oxidized cellulose and vitamin E blend for topical hemostatic applications |
US8696362B2 (en) | 1996-05-08 | 2014-04-15 | Gaumard Scientific Company, Inc. | Interactive education system for teaching patient care |
US5964239A (en) | 1996-05-23 | 1999-10-12 | Hewlett-Packard Company | Housing assembly for micromachined fluid handling structure |
GB2314842B (en) | 1996-06-28 | 2001-01-17 | Johnson & Johnson Medical | Collagen-oxidized regenerated cellulose complexes |
US5891074A (en) | 1996-08-22 | 1999-04-06 | Avitar, Inc. | Pressure wound dressing |
CA2213936C (en) | 1996-08-27 | 2002-01-29 | Rengo Co., Ltd. | Inorganic porous crystals-hydrophilic macromolecule composite |
US5834008A (en) | 1996-09-19 | 1998-11-10 | U.S. Biomaterials Corp. | Composition and method for acceleration of wound and burn healing |
USD386002S (en) | 1996-10-01 | 1997-11-11 | Hinkle Gerald F | Combined pouch for first aid safety kit with instruction card |
US8323305B2 (en) | 1997-02-11 | 2012-12-04 | Cardiva Medical, Inc. | Expansile device for use in blood vessels and tracts in the body and method |
US6037280A (en) | 1997-03-21 | 2000-03-14 | Koala Konnection | Ultraviolet ray (UV) blocking textile containing particles |
JPH10298824A (en) | 1997-04-22 | 1998-11-10 | Chisso Corp | Fiber and fibrous formed product using the same |
US5941897A (en) | 1997-05-09 | 1999-08-24 | Myers; Gene E. | Energy activated fibrin plug |
JPH10337302A (en) | 1997-06-06 | 1998-12-22 | Unitika Ltd | Tympanic membrane absence closure promoting material and manufacture thereof |
GB2326827B (en) | 1997-06-30 | 2002-02-20 | Johnson & Johnson Medical | Use of molecular sieves to promote wound healing |
JPH1171228A (en) | 1997-07-04 | 1999-03-16 | Shiseido Co Ltd | Water-in-oil emulsion composition |
JP3311650B2 (en) * | 1997-08-19 | 2002-08-05 | 日本碍子株式会社 | Method for manufacturing cordierite-based ceramic honeycomb structure |
WO1999013918A2 (en) | 1997-09-18 | 1999-03-25 | University Of Pittsburgh | Icam-1 selective echogenic microbubbles |
US6159232A (en) * | 1997-12-16 | 2000-12-12 | Closys Corporation | Clotting cascade initiating apparatus and methods of use and methods of closing wounds |
JPH11178912A (en) | 1997-12-22 | 1999-07-06 | Kyocera Corp | Organism prosthetic material |
US6372333B1 (en) | 1998-02-25 | 2002-04-16 | Rengo Co., Ltd. | Composition containing inorganic porous crystals-hydrophilic macromolecule composite and product made therefrom |
AU3065999A (en) | 1998-03-10 | 1999-09-27 | Children's Hospital Of Philadelphia, The | Compositions and methods for treatment of asthma |
US7018392B2 (en) * | 1998-04-08 | 2006-03-28 | Arthrocare Corporation | Hemostatic system for body cavities |
US6086970A (en) * | 1998-04-28 | 2000-07-11 | Scimed Life Systems, Inc. | Lubricious surface extruded tubular members for medical devices |
JPH11332909A (en) | 1998-05-22 | 1999-12-07 | Frontier:Kk | Absorbent for absorption of salt-containing solution |
RU2176822C2 (en) | 1998-07-27 | 2001-12-10 | Лутаенко Вячеслав Федорович | Trainer for taking of emergency medical care |
US6123925A (en) | 1998-07-27 | 2000-09-26 | Healthshield Technologies L.L.C. | Antibiotic toothpaste |
CN1181809C (en) | 1998-09-25 | 2004-12-29 | 花王株式会社 | Compositions for oral cavity |
US20020197302A1 (en) | 1998-11-12 | 2002-12-26 | Cochrum Kent C. | Hemostatic polymer useful for rapid blood coagulation and hemostasis |
JP4558208B2 (en) | 1998-11-24 | 2010-10-06 | ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド | Effective coating as an active ingredient distributor on absorbent bandages and bandages |
JP4236751B2 (en) | 1999-01-27 | 2009-03-11 | 日東電工株式会社 | Medical adhesive tape or sheet, and emergency bandage |
US6060461A (en) | 1999-02-08 | 2000-05-09 | Drake; James Franklin | Topically applied clotting material |
US6663878B1 (en) | 1999-04-29 | 2003-12-16 | Usbiomaterials Corp. | Anti-inflammatory bioactive glass particulates |
US6203512B1 (en) | 1999-06-28 | 2001-03-20 | The Procter & Gamble Company | Method for opening a packaging device and retrieving an interlabial absorbent article placed therein |
WO2001002896A1 (en) | 1999-07-02 | 2001-01-11 | E-Vision, L.L.C. | System, apparatus, and method for reducing birefringence |
JP3423261B2 (en) * | 1999-09-29 | 2003-07-07 | 三洋電機株式会社 | Display device |
US6763373B2 (en) | 1999-10-13 | 2004-07-13 | Datahouse Labs, Inc. | Method and system for creating and sending handwritten or handdrawn messages |
US6450537B2 (en) | 2000-01-24 | 2002-09-17 | Polaroid Corporation | Self-service postage stamp assemblage |
KR100721752B1 (en) | 2000-01-24 | 2007-05-25 | 쿠라레 메디카루 가부시키가이샤 | Water-swellable polymer gel and process for preparing the same |
US6187347B1 (en) | 2000-02-09 | 2001-02-13 | Ecosafe, Llc. | Composition for arresting the flow of blood and method |
NZ522121A (en) | 2000-04-28 | 2005-11-25 | Biolife L | Method of arresting blood flow comprising application of an oxyacid ferrate (IV) salt to the wound |
US20020141964A1 (en) | 2001-01-19 | 2002-10-03 | Patterson James A. | Composition for arresting the flow of blood and method |
US6592888B1 (en) | 2000-05-31 | 2003-07-15 | Jentec, Inc. | Composition for wound dressings safely using metallic compounds to produce anti-microbial properties |
WO2001097826A2 (en) | 2000-06-16 | 2001-12-27 | University Of Medicine And Dentistry Of New Jersey | Hemostatic compositions, devices and methods |
US6523778B2 (en) * | 2000-06-29 | 2003-02-25 | The Night Fun Co., Llc | Illuminated emergency signaling device and flying balloon |
US6685227B2 (en) * | 2000-07-14 | 2004-02-03 | Safer Sleep Limited | Label, a label system and method |
IL138099A0 (en) | 2000-08-25 | 2001-10-31 | Naimer Richard | Bandage |
US20040013715A1 (en) | 2001-09-12 | 2004-01-22 | Gary Wnek | Treatment for high pressure bleeding |
US20030165560A1 (en) | 2000-09-14 | 2003-09-04 | Shigenori Otsuka | Preparations for coating wound |
ATE460146T1 (en) | 2000-09-15 | 2010-03-15 | Bruder Healthcare Co | WOUND AND TREATMENT COMPRESS AND DRESSING |
AU2002211686A1 (en) | 2000-10-13 | 2002-04-22 | On Site Gas Systems, Inc. | Bandage using molecular sieves |
RU2189256C2 (en) * | 2000-11-16 | 2002-09-20 | Закрытое акционерное общество "Оргполимерсинтез" | Plastic matrix for mechanical immobilization of medicinal substances and cosmetic agents |
ATE312579T1 (en) | 2001-01-31 | 2005-12-15 | Missak Kechichian | ABSORBENT PRODUCT |
CN1516595A (en) | 2001-03-19 | 2004-07-28 | Iomai公司 | Patch for transcutaneous immunization |
US20040166172A1 (en) | 2001-03-27 | 2004-08-26 | Coni Rosati | Bioctive tissue abrasives |
US6481134B1 (en) | 2001-04-02 | 2002-11-19 | Alicia Aledo | Tag for attaching to a garment having an attribute and identifying the attribute to a person unable to visually identify the attribute |
US6622856B2 (en) | 2001-04-25 | 2003-09-23 | Johnson & Johnson Consumer Companies, Inc. | Relief kit |
ES2342048T3 (en) | 2001-05-09 | 2010-07-01 | Biointeractions Ltd. | SYSTEM AND METHOD FOR SUTURING WOUNDS. |
JP4853887B2 (en) | 2001-05-09 | 2012-01-11 | 日東電工株式会社 | Adhesives and adhesive bandages and emergency bandages |
US20050147656A1 (en) | 2001-06-14 | 2005-07-07 | Hemcon, Inc. | Tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
AU2002350088A1 (en) | 2001-06-22 | 2003-01-08 | Millard Marsden Mershon | Compositions and methods for reducing blood and fluid loss from open wounds |
US20030073249A1 (en) | 2001-07-07 | 2003-04-17 | Lee Duen | Allergen detection chip |
US7429252B2 (en) | 2001-12-12 | 2008-09-30 | Ogenix Corporation | Oxygen producing device for woundcare |
MXPA04006438A (en) | 2001-12-31 | 2005-06-08 | Ares Lab Llc | Hemostatic compositions and methods for controlling bleeding. |
US20050119112A1 (en) * | 2002-01-22 | 2005-06-02 | Zeochem, Llc | Process for production of molecular sieve adsorbent blends |
US7544177B2 (en) | 2002-01-24 | 2009-06-09 | The Regents Of The University Of California | Aerosol device to deliver bioactive agent |
AU2003225543A1 (en) | 2002-02-04 | 2003-09-02 | Damage Control Surgical Technologies, Inc. | Method and apparatus for improved hemostasis and damage control operations |
DE60325184D1 (en) | 2002-03-01 | 2009-01-22 | Immunomedics Inc | RS7 ANTIBODY |
US20030175333A1 (en) | 2002-03-06 | 2003-09-18 | Adi Shefer | Invisible patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin |
JP2003305079A (en) | 2002-04-17 | 2003-10-28 | Sekisui Film Kk | Adhesive tape |
US20030199922A1 (en) | 2002-04-22 | 2003-10-23 | Buckman James S. | Pneumatic pressure bandage for medical applications |
US20030212357A1 (en) | 2002-05-10 | 2003-11-13 | Pace Edgar Alan | Method and apparatus for treating wounds with oxygen and reduced pressure |
US20060193905A1 (en) | 2002-05-14 | 2006-08-31 | University Of Louisville Research Foundation, Inc. | Direct cellular energy delivery system |
JP2005534647A (en) * | 2002-06-07 | 2005-11-17 | ダイアックス、コープ | Prevention and reduction of blood loss |
US8269058B2 (en) | 2002-06-14 | 2012-09-18 | Hemcon Medical Technologies, Inc. | Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
US20050137512A1 (en) | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
US7279177B2 (en) | 2002-06-28 | 2007-10-09 | Ethicon, Inc. | Hemostatic wound dressings and methods of making same |
US20040101546A1 (en) * | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
GB2393120A (en) | 2002-09-18 | 2004-03-24 | Johnson & Johnson Medical Ltd | Compositions for wound treatment |
JP3794365B2 (en) | 2002-10-04 | 2006-07-05 | 憲司 中村 | Warming deodorant sterilizing compound and heat retaining deodorizing sterilizing material |
US6745720B2 (en) | 2002-10-29 | 2004-06-08 | Cycle Group Limited Of Delaware | Clumping animal litter and method of making same |
US6890177B2 (en) | 2002-12-02 | 2005-05-10 | Centrix, Inc. | Method and device for the retraction and hemostasis of tissue during crown and bridge procedures |
US6701649B1 (en) * | 2002-12-12 | 2004-03-09 | Gunter Brosi | Combat identification marker |
US7060795B2 (en) | 2002-12-19 | 2006-06-13 | Kimberly-Clark Worldwide, Inc. | Wound care compositions |
AU2002353388A1 (en) | 2002-12-20 | 2004-07-14 | Council Of Scientific And Industrial Research | Herbal composition for cuts, burns and wounds |
MXPA05005755A (en) | 2002-12-20 | 2005-08-16 | Procter & Gamble | Tufted fibrous web. |
US7994078B2 (en) | 2002-12-23 | 2011-08-09 | Kimberly-Clark Worldwide, Inc. | High strength nonwoven web from a biodegradable aliphatic polyester |
JP3975944B2 (en) | 2003-02-27 | 2007-09-12 | 住友電気工業株式会社 | HOLDER FOR SEMICONDUCTOR OR LIQUID CRYSTAL MANUFACTURING DEVICE AND SEMICONDUCTOR OR LIQUID CRYSTAL MANUFACTURING DEVICE WITH THE SAME |
US7322976B2 (en) | 2003-03-04 | 2008-01-29 | Cardiva Medical, Inc. | Apparatus and methods for closing vascular penetrations |
JP4589608B2 (en) | 2003-06-24 | 2010-12-01 | ニプロパッチ株式会社 | Pressure sensitive adhesive tape |
KR100544123B1 (en) * | 2003-07-29 | 2006-01-23 | 삼성에스디아이 주식회사 | Flat panel display |
US7109304B2 (en) | 2003-07-31 | 2006-09-19 | Immunomedics, Inc. | Humanized anti-CD19 antibodies |
US8012167B2 (en) * | 2003-08-14 | 2011-09-06 | Loma Linda University Medical Center | Vascular wound closure device and method |
US20050143689A1 (en) | 2003-08-17 | 2005-06-30 | Ramsey Maynard Iii | Internal compression tourniquet catheter system and method for wound track navigation and hemorrhage control |
US7125821B2 (en) | 2003-09-05 | 2006-10-24 | Exxonmobil Chemical Patents Inc. | Low metal content catalyst compositions and processes for making and using same |
EP1667623B1 (en) | 2003-09-12 | 2010-11-24 | Z-Medica Corporation | Partially hydrated hemostatic agent |
WO2005027808A1 (en) | 2003-09-12 | 2005-03-31 | Z-Medica Corporation | Calcium zeolite hemostatic agent |
CA2443059A1 (en) * | 2003-09-29 | 2005-03-29 | Le Groupe Lysac Inc. | Polysaccharide-clay superabsorbent nanocomposites |
NZ547140A (en) | 2003-10-22 | 2009-09-25 | Encelle Inc | Bioactive hydrogel compositions in dehydrated form for regenerating connective tissue |
CA2545813C (en) | 2003-11-14 | 2011-01-04 | Shanghai Genomics, Inc. | The derivatives of pyridone and use thereof |
WO2005087280A1 (en) | 2004-03-11 | 2005-09-22 | Medtrade Products Limited | Compositions of alpha and beta chitosan and methods of preparing them |
ATE534424T1 (en) | 2004-03-19 | 2011-12-15 | Abbott Lab | MULTIPLE MEDICINAL DELIVERY FROM A BALLOON AND A PROSTHESIS |
GB0407502D0 (en) | 2004-04-02 | 2004-05-05 | Inotec Amd Ltd | Hyperbaric dressing |
US9017374B2 (en) | 2004-04-09 | 2015-04-28 | Cardiva Medical, Inc. | Device and method for sealing blood vessels |
US7572274B2 (en) | 2004-05-27 | 2009-08-11 | Cardiva Medical, Inc. | Self-tensioning vascular occlusion device and method for its use |
US20080154303A1 (en) | 2006-12-21 | 2008-06-26 | Cardiva Medical, Inc. | Hemostasis-enhancing device and method for its use |
US7993366B2 (en) | 2004-05-27 | 2011-08-09 | Cardiva Medical, Inc. | Self-tensioning vascular occlusion device and method for its use |
US20050226911A1 (en) | 2004-04-13 | 2005-10-13 | Bringley Joseph F | Article for inhibiting microbial growth in physiological fluids |
US20050248270A1 (en) | 2004-05-05 | 2005-11-10 | Eastman Kodak Company | Encapsulating OLED devices |
US20050249899A1 (en) | 2004-05-06 | 2005-11-10 | Bonutti Peter M | Biodegradable packaging material |
GB2415382A (en) | 2004-06-21 | 2005-12-28 | Johnson & Johnson Medical Ltd | Wound dressings for vacuum therapy |
US8916208B2 (en) | 2004-06-24 | 2014-12-23 | California Institute Of Technology | Aluminophosphate-based materials for the treatment of wounds |
US7326043B2 (en) | 2004-06-29 | 2008-02-05 | Cornell Research Foundation, Inc. | Apparatus and method for elevated temperature electrospinning |
US20060008505A1 (en) * | 2004-07-08 | 2006-01-12 | Brandon Gerard J | Product |
US20060034935A1 (en) * | 2004-07-22 | 2006-02-16 | Pronovost Allan D | Compositions and methods for treating excessive bleeding |
US20060078628A1 (en) | 2004-10-09 | 2006-04-13 | Karl Koman | Wound treating agent |
US20060116635A1 (en) | 2004-11-29 | 2006-06-01 | Med Enclosure L.L.C. | Arterial closure device |
US20060121101A1 (en) * | 2004-12-08 | 2006-06-08 | Ladizinsky Daniel A | Method for oxygen treatment of intact skin |
US8535709B2 (en) | 2004-12-13 | 2013-09-17 | Southeastern Medical Technologies, Llc | Agents for controlling biological fluids and methods of use thereof |
US20060127437A1 (en) | 2004-12-13 | 2006-06-15 | Misty Anderson Kennedy | Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids |
US20060141060A1 (en) * | 2004-12-27 | 2006-06-29 | Z-Medica, Llc | Molecular sieve materials having increased particle size for the formation of blood clots |
US20060178609A1 (en) | 2005-02-09 | 2006-08-10 | Z-Medica, Llc | Devices and methods for the delivery of molecular sieve materials for the formation of blood clots |
EP1853326B1 (en) | 2005-02-15 | 2016-06-15 | Virginia Commonwealth University | Mineral technologies (mt) for acute hemostasis and for the treatment of acute wounds and chronic ulcers |
GB0504445D0 (en) * | 2005-03-03 | 2005-04-06 | Univ Cambridge Tech | Oxygen generation apparatus and method |
US20060211965A1 (en) | 2005-03-16 | 2006-09-21 | Z-Medica, Llc | Device for the delivery of blood clotting materials to a wound site |
US20060211971A1 (en) | 2005-03-16 | 2006-09-21 | Z-Medica, Llc | Pillow for the delivery of blood clotting materials to a wound site |
EP1868621A1 (en) | 2005-04-04 | 2007-12-26 | The Regents of the University of California | Inorganic materials for hemostatic modulation and therapeutic wound healing |
US9326995B2 (en) | 2005-04-04 | 2016-05-03 | The Regents Of The University Of California | Oxides for wound healing and body repair |
US20060282046A1 (en) | 2005-04-13 | 2006-12-14 | Horn Jeffrey L | Device and method for subcutaneous delivery of blood clotting agent |
EP1714642A1 (en) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
JP4693522B2 (en) * | 2005-06-29 | 2011-06-01 | キヤノン株式会社 | Imaging device |
US20070004995A1 (en) | 2005-06-30 | 2007-01-04 | Horn Jeffrey L | Swab device and kit for the delivery of blood clotting materials to a wound site |
US7438705B2 (en) * | 2005-07-14 | 2008-10-21 | Boehringer Technologies, L.P. | System for treating a wound with suction and method detecting loss of suction |
US8063264B2 (en) | 2005-08-26 | 2011-11-22 | Michael Spearman | Hemostatic media |
JP2009507925A (en) * | 2005-09-13 | 2009-02-26 | エラン ファーマ インターナショナル リミテッド | Nanoparticle tadalafil formulation |
EP1810697A3 (en) | 2005-11-07 | 2008-04-02 | Jeffrey L. Horn | Devices for the delivery of molecular sieve materials for the formation of blood clots |
US20070104768A1 (en) | 2005-11-07 | 2007-05-10 | Z-Medica Corporation | Devices for the delivery of molecular sieve materials for the formation of blood clots |
US20090076475A1 (en) | 2005-11-09 | 2009-03-19 | Oxysure Systems Inc. | Method and apparatus for delivering therapeutic oxygen treatments |
US20100168767A1 (en) | 2008-06-30 | 2010-07-01 | Cardiva Medical, Inc. | Apparatus and methods for delivering hemostatic materials for blood vessel closure |
US7691127B2 (en) | 2005-12-13 | 2010-04-06 | Cardiva Medical, Inc. | Drug eluting vascular closure devices and methods |
US8911472B2 (en) | 2005-12-13 | 2014-12-16 | Cardiva Medical, Inc. | Apparatus and methods for delivering hemostatic materials for blood vessel closure |
US9179897B2 (en) | 2005-12-13 | 2015-11-10 | Cardiva Medical, Inc. | Vascular closure devices and methods providing hemostatic enhancement |
US20070142783A1 (en) * | 2005-12-16 | 2007-06-21 | Huey Raymond J | Devices and methods for promoting the formation of blood clots at dialysis access sites |
US20070154509A1 (en) | 2005-12-30 | 2007-07-05 | Wilcher Steve A | Adsorbent-Containing Hemostatic Devices |
US20070154510A1 (en) | 2005-12-30 | 2007-07-05 | Wilcher Steve A | Adsorbent-Containing Hemostatic Devices |
US9474652B2 (en) | 2006-01-09 | 2016-10-25 | Jack Mentkow | Hemostatic agent delivery system |
US8409629B2 (en) | 2006-01-09 | 2013-04-02 | Jack Mentkow | Hemostatic agent composition and method of delivery |
US8277837B2 (en) | 2006-01-11 | 2012-10-02 | Entegrion, Inc. | Hemostatic textile |
US20070167971A1 (en) * | 2006-01-17 | 2007-07-19 | Raymond Huey | Devices and methods for promoting the formation of blood clots in esophageal varices |
JPWO2007111127A1 (en) * | 2006-03-27 | 2009-08-13 | 東京エレクトロン株式会社 | Substrate processing method, semiconductor device manufacturing method, substrate processing apparatus, and recording medium |
FR2899479B1 (en) | 2006-04-10 | 2009-07-24 | Agelys Lab | CICATRISANTE COMPOSITION |
US20090011394A1 (en) | 2006-04-14 | 2009-01-08 | Simquest Llc | Limb hemorrhage trauma simulator |
US8938898B2 (en) | 2006-04-27 | 2015-01-27 | Z-Medica, Llc | Devices for the identification of medical products |
FR2900824A1 (en) | 2006-05-10 | 2007-11-16 | Prod Dentaires Pierre Rolland | PASTE FOR STOPPING BLEEDINGS, USES, AND SYRINGE CONTAINING SAME |
US8202532B2 (en) | 2006-05-26 | 2012-06-19 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US7968114B2 (en) | 2006-05-26 | 2011-06-28 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US20070276308A1 (en) | 2006-05-26 | 2007-11-29 | Huey Raymond J | Hemostatic agents and devices for the delivery thereof |
US7604819B2 (en) | 2006-05-26 | 2009-10-20 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
MX2008015275A (en) | 2006-05-30 | 2009-02-06 | Elan Pharma Int Ltd | Nanoparticulate posaconazole formulations. |
US20080027365A1 (en) * | 2006-06-01 | 2008-01-31 | Huey Raymond J | Hemostatic device with oxidized cellulose pad |
CN1970090B (en) | 2006-09-14 | 2015-11-25 | 华东理工大学 | Nanometer mesoporous silicon based xerogel hemostatic material and its preparation method and application |
US9198995B2 (en) | 2006-09-20 | 2015-12-01 | Ore-Medix Llc | Conformable structured therapeutic dressing |
US20080085300A1 (en) * | 2006-10-06 | 2008-04-10 | Z-Medica Corporation | Hemostatic compositions and method of manufacture |
US20080097271A1 (en) * | 2006-10-20 | 2008-04-24 | Z-Medica Corporation | Devices and methods for the delivery of hemostatic agents to bleeding wounds |
US20080125686A1 (en) * | 2006-11-29 | 2008-05-29 | Denny Lo | Heat mitigating hemostatic agent |
US20080145455A1 (en) | 2006-12-13 | 2008-06-19 | Bedard Robert L | Combination of Inorganic Hemostatic Agents with Other Hemostatic Agents |
US20100184348A1 (en) | 2006-12-20 | 2010-07-22 | Imerys Pigments, Inc. | Spunlaid Fibers Comprising Coated Calcium Carbonate, Processes For Their Production, and Nonwoven Products |
US8703634B2 (en) | 2007-02-21 | 2014-04-22 | The Regents Of The University Of California | Hemostatic compositions and methods of use |
US20080206134A1 (en) | 2007-02-22 | 2008-08-28 | Denny Lo | Radio-opaque hemostatic agents and devices and methods for the delivery thereof |
US20080254146A1 (en) | 2007-04-13 | 2008-10-16 | Z-Medica Corporation | Method of providing hemostasis in anti-coagulated blood |
US20080254147A1 (en) | 2007-04-13 | 2008-10-16 | Z-Medica Corporation | Method of providing hemostasis in anti-coagulated blood |
CN101104080B (en) | 2007-04-24 | 2011-06-22 | 深圳市鸿华投资有限公司 | Zeolite hemostatic dressings and preparation method and application thereof |
US20080319476A1 (en) | 2007-05-22 | 2008-12-25 | Ward Kevin R | Hemostatic mineral compositions and uses thereof |
WO2008157536A2 (en) | 2007-06-21 | 2008-12-24 | Z-Medica Corporation | Hemostatic sponge and method of making the same |
WO2009021047A2 (en) * | 2007-08-06 | 2009-02-12 | Ohio Medical Corporation | Wound treatment system and suction regulator for use therewith |
US20090047366A1 (en) * | 2007-08-15 | 2009-02-19 | Bedard Robert L | Inorganic Coagulation Accelerators for Individuals taking Platelet Blockers or Anticoagulants |
US20090053288A1 (en) | 2007-08-20 | 2009-02-26 | Eskridge Jr E Stan | Hemostatic woven fabric |
US20090162406A1 (en) * | 2007-09-05 | 2009-06-25 | Z-Medica Corporation | Wound healing with zeolite-based hemostatic devices |
US8287506B2 (en) * | 2007-10-26 | 2012-10-16 | Electrochemical Oxygen Concepts, Inc. | Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability |
US8883194B2 (en) | 2007-11-09 | 2014-11-11 | Honeywell International, Inc. | Adsorbent-containing hemostatic devices |
US8319002B2 (en) | 2007-12-06 | 2012-11-27 | Nanosys, Inc. | Nanostructure-enhanced platelet binding and hemostatic structures |
US20100035045A1 (en) * | 2008-01-21 | 2010-02-11 | Imerys Pigments, Inc. | Fibers comprising at least one filler and processes for their production |
US20110059287A1 (en) | 2008-01-21 | 2011-03-10 | Imerys Pigments, Inc. | Fibers comprising at least one filler, processes for their production, and uses thereof |
CA2714490C (en) | 2008-02-25 | 2016-01-05 | Teikoku Seiyaku Co., Ltd. | Wound-covering hydrogel material |
JP5569398B2 (en) | 2008-02-29 | 2014-08-13 | フェッローサン メディカル ディバイス エー/エス | Device for promoting hemostasis and / or wound healing |
AU2009234203B2 (en) | 2008-04-11 | 2014-06-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Electrospun dextran fibers and devices formed therefrom |
GB2461019B (en) | 2008-04-25 | 2013-06-05 | Medtrade Products Ltd | Haemostatic material |
CA2723172A1 (en) | 2008-05-02 | 2009-11-05 | Providence Health System-Oregon D/B/A Providence St. Vincent Medical Cen Ter | Wound dressing devices and methods |
AU2009244462B2 (en) | 2008-05-06 | 2013-04-11 | Cook Medical Technologies Llc | Apparatus and methods for delivering therapeutic agents |
US20100080791A1 (en) | 2008-09-26 | 2010-04-01 | Rousseau Robert A | Composition and Method For Treating Tissue Defects |
US8780054B2 (en) | 2008-09-26 | 2014-07-15 | Lg Electronics Inc. | Mobile terminal and control method thereof |
EP2172167A1 (en) | 2008-10-02 | 2010-04-07 | 3M Innovative Properties Company | Dental retraction device and process of its production |
CA2746736C (en) | 2008-12-18 | 2017-08-01 | Fmc Corporation | Peracetic acid oil-field biocide and method |
EP2375960B1 (en) | 2008-12-23 | 2018-10-31 | Cook Medical Technologies LLC | Apparatus for containing and delivering therapeutic agents |
WO2010102283A2 (en) | 2009-03-06 | 2010-09-10 | Jack Mentkow | Hemostatic agent composition, delivery system and method |
US8118777B2 (en) | 2009-05-29 | 2012-02-21 | Cook Medical Technologies Llc | Systems and methods for delivering therapeutic agents |
WO2010148078A2 (en) | 2009-06-16 | 2010-12-23 | Simquest Llc | Hemorrhage control simulator |
US20110015565A1 (en) * | 2009-07-15 | 2011-01-20 | Hursey Francis X | Gas dispenser with therapeutic agent |
US9370347B2 (en) | 2010-02-10 | 2016-06-21 | Cardiva Medical, Inc. | Bilateral vessel closure |
US20110237994A1 (en) | 2010-03-25 | 2011-09-29 | Combat Medical Systems, Llc | Void-filling wound dressing |
US20120004636A1 (en) | 2010-07-02 | 2012-01-05 | Denny Lo | Hemostatic fibrous material |
US8858969B2 (en) | 2010-09-22 | 2014-10-14 | Z-Medica, Llc | Hemostatic compositions, devices, and methods |
CN201920992U (en) | 2010-12-29 | 2011-08-10 | 稳健实业(深圳)有限公司 | Medical dressing |
US20130060279A1 (en) | 2011-09-02 | 2013-03-07 | Cardiva Medical, Inc. | Catheter with sealed hydratable hemostatic occlusion element |
CN102274541A (en) | 2011-09-09 | 2011-12-14 | 天津禹王生物医药科技有限公司 | Hemostatic material |
BR112014031439A8 (en) | 2012-06-22 | 2023-01-31 | Z Medica Llc | HEMOSTATIC AND WOUND DEVICES AND DRESSINGS AND PROCESSES FOR PRODUCING HEMOSTATIC AND WOUND DEVICE |
CN104641407A (en) | 2012-09-21 | 2015-05-20 | Z-医疗有限责任公司 | Systems and methods for providing hemorrhage control training |
US9867931B2 (en) | 2013-10-02 | 2018-01-16 | Cook Medical Technologies Llc | Therapeutic agents for delivery using a catheter and pressure source |
US9502099B2 (en) | 2014-11-14 | 2016-11-22 | Cavium, Inc. | Managing skew in data signals with multiple modes |
US10531868B2 (en) | 2017-12-01 | 2020-01-14 | Cardiva Medical, Inc. | Apparatus and methods for accessing and closing multiple penetrations on a blood vessel |
-
2007
- 2007-03-06 US US11/715,057 patent/US7604819B2/en active Active
-
2008
- 2008-03-06 CN CN201610509518.7A patent/CN106110366B/en active Active
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112451213A (en) * | 2020-11-24 | 2021-03-09 | 江西美宝利医用敷料有限公司 | Antibacterial hemostatic gauze |
CN112451213B (en) * | 2020-11-24 | 2022-03-25 | 江西美宝利医用敷料有限公司 | Antibacterial hemostatic gauze |
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