CA2766682A1 - External mixer assembly - Google Patents

External mixer assembly Download PDF

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Publication number
CA2766682A1
CA2766682A1 CA2766682A CA2766682A CA2766682A1 CA 2766682 A1 CA2766682 A1 CA 2766682A1 CA 2766682 A CA2766682 A CA 2766682A CA 2766682 A CA2766682 A CA 2766682A CA 2766682 A1 CA2766682 A1 CA 2766682A1
Authority
CA
Canada
Prior art keywords
assembly
conduits
adhesive
deflector plate
deflector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2766682A
Other languages
French (fr)
Inventor
Clifford L. Emmons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covidien LP
Original Assignee
Tyco Healthcare Group LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tyco Healthcare Group LP filed Critical Tyco Healthcare Group LP
Publication of CA2766682A1 publication Critical patent/CA2766682A1/en
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00503—Details of the outlet element
    • B05C17/00516—Shape or geometry of the outlet orifice or the outlet element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/00553—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with means allowing the stock of material to consist of at least two different components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

Abstract

A fluid delivery system for dispensing a multicomponent biological adhesive, the system comprising: a conduit assembly housed within a housing, the conduit assembly having two conduits each having an exit opening; a reservoir assembly having a first reservoir containing the first adhesive component and a second reservoir containing the second adhesive component, the first and second reservoirs being in fluid communication with a respective one of the two conduits, wherein the first and second reservoirs each include a sealable opening configured for being penetrated by a proximal end of the two conduits; and a deflector assembly having a deflector plate displaced at a distance from a distal end of the housing for receiving the first and the second adhesive components from the two conduits and deflecting the first and second adhesive components prior to dispensing to an application site, wherein the deflector plate is substantially parallel to each of the exit openings.

Description

EXTERNAL MIXER ASSEMBLY
This is a division of Canadian 2,438,858 filed February 27, 2002.
BACKGROUND
1. Technical Field The disclosure relates generally to a fluid delivery system for biological as well as synthetic sealants, hemostats and adhesives and, more particularly, to an external mixer assembly for mixing and delivering biological and/or synthetic biocompatible sealants, hemostats and adhesives to tissues or organs for sealing wounds, stopping bleeding and the like.
2. Description of Related Art Biologically derived as well as synthetic sealants, hemostats and/or adhesives are used to treat wounds in instances where external dressings or sutures are not totally effective. A common treatment takes advantages of the rapid polymerization which occurs when a solution of proteomic clottip,g factors, such as fibrinogen, comes into contact with a solution of a proteomic catalyst, such as thrombin, to form a complex which acts as a hemostatic agent and as a tissue adhesive. This rapid polymerization typically commences within two seconds after the solutions initially contact one another, and it typically attains a soft set within ten seconds of contact. A
common name for such a complex is fibrin glue or fibrin sealant.
The protein components of fibrinogen and thrombin which, together with a variety of known adjuvants, form a fibrin sealant are typically derived from human plasma and are subjected to virus elimination procedures. The components are typically individually dehydrated and stored in separate vials as sterile freeze-dried powders.

Because of the rapid polymerization upon intimate interaction of fibrinogen and thrombin, it is important to maintain these two blood proteins separate until applied at the application site. These protein solutions are generally delivered by fluid delivery systems, such as a dual syringe apparatus, where each solution is confined within a separate syringe prior to mixing.

One dual syringe apparatus for applying a fibrinogen-based tissue adhesive is disclosed in U.S. Pat. No. 4,359,049 to Red] et al. Redl et al. disclose a mechanism in which two standardized one-way syringes are held in a support having a common actuating means., The dispensing end of each syringe is inserted into a collection manifold where the two components are mixed. The components are then dispensed through a common needle capable of covering a limited area of the application site.
It is often desirable or necessary to cover a broad area of a wound, either to stop bleeding, to fix tissue or to prevent infection. It is also desirable to prevent the two components from mixing within the dispensing device.

Further, all known devices for dispensing solutions of fibrinogen and thrombin require the addition of these proteins in powdered form to the body of the syringe.
This makes the proteins susceptible to contamination by impurities which may enter the syringe body. Further still, the use of the syringe body to mix the proteins with water to create the protein solutions can cause the solutions to leak out from either the dispensing end of each syringe or the proximal end of the syringe body.

Additionally, a dual syringe apparatus for the application of fibrinogen and thrombin solutions to an application site generally contains several parts, such as a syringe plunger, a "Y" manifold connector, a dispensing needle, a syringe holder, syringe needles, and conduits for transporting the solutions to the dispensing needle.
Therefore, known fibrin sealant delivery systems or applicators, such as disclosed in U.S. Patent to Redl et al. discussed above, and in U.S. Patent Nos. 4,874,368 to Miller et al. and 4,979,942 to Wolf et al. are difficult to reuse. The replenishment of the protein components typically require removing a clip which couples the syringe plunger, removing the syringe plunger, detaching the syringes from the "Y"
connector, removing the syringes from the holder, inserting new syringes, affixing the syringes to the "Y" connector, adding fibrinogen to one syringe and thrombin to another syringe, adding sterile water to each syringe, replacing the syringe plunger, replacing the plunger clip, and mixing the solutions. In an application where time is of the essence, such a lengthy replenishing process is impractical and cumbersome.

Furthermore, known fluid delivery systems for dispensing a biological adhesive require the manual exertion of a force on the protein components so they can be dispensed from the fluid delivery system. Typically, a manual force is exerted on the components by means of the plunger in the standard one-way syringe. This type of arrangement is shown in U.S. Patent Nos. 4,359,049 discussed above, and 4,631,055 to Redl et al. Manually exerting a force on a plunger located at proximal end of the fluid delivery system can make the application of the adhesive difficult. For example, the user is unable to clearly view the application site when holding the fluid delivery system perpendicularly to the application site. Further, such an arrangement causes air to enter the syringes causing difficulty in exerting a force via the syringe plunger.

Thus, there is a need in the art for a fluid delivery system for applying a tissue adhesive wherein the adhesive covers a broad area of a wound, either to stop bleeding, to fix tissue or to prevent infection. There is also a need for a fluid delivery system wherein the adhesive components are not susceptible to contamination and the adhesive components are not intermixed within the fluid delivery system. Further, there is a need for a fluid delivery system wherein the component solutions are easily replenished.
There is also a need for a fluid delivery system which is self-cleaning and reusable with different component solutions. Further, there is a need for a fluid delivery system which is inexpensive to manufacture for allowing the fluid delivery system to be disposed of after use. Additionally, there is a need for a fluid delivery system which avoids wasting adhesive solution and allows the application site to be clearly seen by the user when applying the component solutions perpendicular to the application site.

SUMMARY
A fluid delivery system is provided which is referred to herein as an external mixer assembly. The external mixer assembly externally mixes and delivers a first and a second component of a biological adhesive to tissues or organs for sealing wounds, stopping bleeding and the like. The first and second components are mixed immediately after exiting from separate outlet ports disposed in fluid communication with component reservoirs.

In a preferred embodiment, the external mixer assembly includes a housing having a housing head for enclosing therein a first reservoir containing the first component, and a second reservoir containing the second component. The housing further includes a discharge nozzle defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. A deflector assembly is connected to the discharge nozzle. The deflector assembly includes a deflector plate to provide a space for initial mixing of the first and second components. It is envisioned that the discharge nozzle and the deflector assembly may be formed into various configurations to provide adequate mixing and dispensing of the first and second components.

In one preferable embodiment, the discharge nozzle includes a distal face having an angular configuration. The deflector plate is oriented in generally parallel juxtaposed relation distal to the distal face of the discharge nozzle. It is envisioned, however, that the deflector plate is disposed in somewhat open or close relation with the distal face of the discharge nozzle depending upon the particular surgical needs. The size and configuration of the deflector plate may be varied. It is also contemplated that the distal face of the discharge nozzle may also be substantially perpendicular to the longitudinal axis of the discharge nozzle. The first and second components are preferably fibrinogen and thrombin which intermix to form a fibrin sealant.

BRIEF DESCRIPTION OF THE DRAWINGS

Various embodiments are described herein with reference to the drawings, wherein:
FIG. 1 is a phantom, perspective view of an external mixer assembly according to one embodiment of the present disclosure;
FIG. 2 is a rear, phantom view of the embodiment illustrated in FIG. 1, showing proximal end portions of the discharge nozzle;
FIG. 3 is a cross-sectional view of the embodiment illustrated in FIG. 2, taken along the line 3-3;
FIG. 4 is a cross-sectional view of the embodiment illustrated in FIG. 2, taken along the line 4-4;
FIG. 5 is a perspective view of an external mixer assembly according to another embodiment of the present disclosure;
FIG. 6 is a front view of the embodiment illustrated in FIG. 5, showing distal end portions of the nozzle tip and deflector plate; and FIG. 7 is a cross-sectional view of the embodiment illustrated in FIG. 6, taken along the line 7-7.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

Referring to FIGS. 1-4, an external mixer assembly according to one embodiment of the present disclosure is illustrated. The assembly designated generally by numeral 100 includes a housing 102 having a housing head 104 and a discharge nozzle 120 defining a longitudinal axis. While the housing head 104 is shown as being a particular shape, it is understood that other shapes that contribute to the ease of gripping and controlling the mixer assembly 100 may be used.
A nozzle tip 106 is provided at a distal end or face 108 of the discharge nozzle 120. The nozzle tip 106 includes two dispensing ports 110a, 110b where each dispensing port is in fluid communication with a respective conduit 112a, 112b of a conduit assembly 114 within the discharge nozzle 120 for dispensing biological components contained within housing head 104. Preferably, the biological components are a fibrinogen solution and a thrombin solution which intermix to form a fibrin sealant. It is to be understood, however, that other biological fluids may be substituted, depending upon the choice of mixture that is to be dispensed.
Housing 102 is preferably formed from molded housing half sections which are formed with internal partitions configured to properly align the internal components of the assembly 100 with respect to each other and to prevent movement of a first 150 and a second reservoir 152 each storing a biological component when the reservoirs 150a, 150b are fitted within reservoir conduits 124 and 126, as shown by FIGS. 3 and 4. The main internal components of the assembly 100 include the conduit assembly 114 and a reservoir assembly 130. The two assemblies 114, 130 are interrelated with each other to dispense the biological components stored within the first and second reservoirs 150a, 150b via the two dispensing ports 110a, 110b.

The assembly 100 further includes a deflector assembly 140 connected to the housing 102 and the discharge nozzle 120 via holders 148 and 149. It is contemplated that holders 148 and 149 may be substituted by one or more other types of connection structure as known in the art. The deflector assembly 140 includes a cylindrical deflector housing 142 housing the discharge nozzle 120 when the deflector assembly 140 is connected to the housing 102 and the discharge nozzle 120.

A deflector plate 144 extends from a distal end of the deflector housing 142.
The deflector plate 144 is displaced a relatively short distance from the distal face 108 of the discharge nozzle 120 to provide a space for initial mixing of the biological components dispensed from the two dispensing ports 110a, 110b.

The deflector plate 144 is configured to facilitate both mixing and directing of the components. The deflector plate 144 is preferably oriented in general parallel relation with the distal face 108 of the discharge nozzle 120. It is contemplated that the deflector plate 144 may be disposed in open or close relation of some degree relative to the distal face 108 of the discharge nozzle 120 depending upon the specific application.
It. is also contemplated that the deflector plate 144 may be pivotably connected to the-deflector housing 142 by a ratchet mechanism for pivoting and locking the deflector plate 144 in one of several positions with respect to the distal face 108 of the discharge nozzle 120 according to particular surgical needs.

The size and configuration of the deflector plate 144, and the gap there-between with the distal face 108 of the discharge nozzle 120, may be varied. The positions and orientations of the dispensing. ports 110a, 110b, relative to the deflector plate 144, may also be varied depending upon surgical needs by changing the alignment of the conduits 112a, 112b with respect to the longitudinal axis of the discharge nozzle 120.
That is, one or both of the conduits 112a, 112b may have one or more curves, the conduits 112a, 112b may be in divergent, convergent or parallel orientation with respect to each other, the conduits 112a, ' 112b may join in proximity to the distal face 108 of the discharge nozzle 120 to form one conduit, etc.

As known in the art, the first and second reservoirs 150a, 150b include a main body or a central throughbore 152 for storing the biological components. A
plug 154 is used to vacuum seal the central throughbore 152 to prevent contamination of the biological components. The plug 154 preferably includes a silicon surface 156 capable of being penetrated by a syringe needle for adding a liquid, preferably sterile water, within the reservoirs 150a, 150b to intermix with the biological components to form protein solutions. The protein solutions are dispensed on the application site as discussed above.. The conduit assembly 114 includes the two conduits 112a, 112b.
Preferably, each conduit includes a beveled proximal tip 60 for penetrating a respective plug 154 of the first and second reservoirs 150a, 150b.

Preferably, the first and second reservoirs 150a, 150b are identical for encasing an equal volumetric amount of their respective protein solution as compared to the other reservoir. It is contemplated to provide a different color for each reservoir 150a, 150b to easily recognize the reservoir containing fibrinogen and the reservoir containing thrombin. It is further contemplated to provide a different shape for each reservoir and to change the shape of one or both of the reservoir conduits 124, 126 accordingly for the same purpose, i.e., to easily recognize the reservoir containing fibrinogen and the reservoir containing thrombin. However, the volumetric amount stored within the first reservoir 150a should be equal to the volumetric amount stored within the second reservoir 150b to maintain a pre-determined fibrinogen to thrombin solution ratio, which is typically a 1:1 ratio.

The first and second reservoirs 150a, 150b are preferably constructed from a flexible material and contain the first and second biological components, respectively.
It is contemplated that the housing half sections are fully or partially transparent, as well as the first and second reservoirs 150a, 150b, for permitting a user to view the amount of solution and to determine if the solution has been sufficiently intermixed before being dispensed on the application site. It is further contemplated to provide calibration markings on the first 150a and second reservoir 150b.

Referring to FIGS. 5-7, an external mixer assembly according to an alternate embodiment of the present disclosure is shown and is designated generally by reference numeral 10. Generally, the external mixer assembly 10 is similar to the external mixer assembly 100 if the housing 102 housing the reservoir assembly 130 is removed and only the discharge nozzle 120 and the deflector assembly 140 remain.

The external mixer assembly 10 includes a discharge nozzle 20 and a deflector assembly 40 connected to a distal end of the discharge nozzle 20. Discharge nozzle 20 includes a nozzle body 22 defining two longitudinal outlet ports 24 and 26 therein in fluid communication with their respective component reservoirs (not shown).
Nozzle body 22 includes a nozzle tip 28 at a distal end portion thereof, which is preferably configured as a cylinder having an angled distal face. It is provided that the component reservoirs may be similar to reservoirs 150a, 150b described above or different.

Deflector assembly 40 includes a connecting portion 42 at a proximal end thereof to connect to the distal end of the nozzle body 22. Deflector assembly further includes a deflector plate 44 at a distal end thereof, which is displaced a relatively short distance from the distal face of the nozzle tip 28 to provide a space for initial mixing of the biological components. The deflector plate 44 is configured to facilitate both mixing and directing of the components. The deflector plate is preferably oriented in general parallel relation with the distal face of the nozzle tip 28.

It is contemplated that the deflector plate 44 may be disposed in open or close relation of some degree relative to the distal face of the nozzle tip 28 depending upon the specific application. It is also contemplated that the deflector plate 44 may be pivotably connected to the connecting portion 42 by a .ratchet mechanism for pivoting and locking the deflector plate 44 in one of several positions with respect to the distal face of the nozzle tip 28 according to particular surgical needs.
The size and configuration of the deflector plate 44, and the gap there-between with the distal- face of the nozzle tip 28, may be varied. The positions and orientations of the outlet ports 24 and 26, relative to the deflector plate 44, may also be varied depending upon surgical needs by changing the alignment of the outlet ports 24 and 26 with respect to the longitudinal axis of the discharge nozzle 20. That is, one or both of the outlet ports 24 and 26 may have one or more curves, the outlet ports 24 and 26 may be in divergent, convergent or parallel orientation 'with respect to each other, the outlet ports 24 and 26 may join in proximity to the distal face of the nozzle tip 28 to form one outlet port, etc.

The external mixer assemblies according to the present disclosure are capable of applying a tissue adhesive where the adhesive covers a broad area of a wound, either to stop bleeding, to fix tissue or to prevent infection. The external mixer assemblies according to the present disclosure prevent the adhesive components from being susceptible to contamination and intermix the adhesive components externally.

Further, the external mixer assembly of the first embodiment allows for the component solutions to be easily replenished by removing the spent reservoirs from the reservoir conduits and replacing them with new reservoirs. Additionally, the external mixer assemblies according to the present disclosure avoid wasting adhesive solution and allow the application site to be clearly seen by the user when applying the component solutions perpendicular to the application site.

It is contemplated that all the embodiments disclosed herein are disposable or have one or more disposable components. It is also contemplated that all the embodiments disclosed herein can be sterilized for re-use.
Therefore, it is understood that various modifications may be made to the embodiments disclosed herein: For example, while specific embodiments of the external mixer assembly have been described in detail, structures that perform substantially the same function in substantially the same way to achieve substantially the same result can also be used. Also, besides applying a fibrin sealant, the external mixer assembly can be used to perform human or veterinary surgical procedures including applying antiseptics, medication and other similar procedures. Therefore, the above description should not be construed as limiting, but merely as exemplifications of 9.

preferred embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended thereto.

Claims (3)

WHAT IS CLAIMED IS:
1. A fluid delivery system for dispensing a multicomponent biological adhesive, the system comprising:
a conduit assembly housed within a housing, said conduit assembly having two conduits each having an exit opening;
a reservoir assembly having a first reservoir containing the first adhesive component and a second reservoir containing the second adhesive component, the first and second reservoirs being in fluid communication with a respective one of the two conduits, wherein the first and second reservoirs each include a sealable opening configured for being penetrated by a proximal end of the two conduits; and a deflector assembly having a deflector plate displaced at a distance from a distal end of said housing for receiving the first and the second adhesive components from the two conduits and deflecting the first and second adhesive components prior to dispensing to an application site, wherein said deflector plate is substantially parallel to each of said exit openings.
2. The system of claim 1, wherein said deflector plate is oriented in general parallel relation to a distal face of said conduit assembly.
3. The system of claim 1, wherein the exit openings are at an angle.
CA2766682A 2001-02-27 2002-02-27 External mixer assembly Abandoned CA2766682A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27179301P 2001-02-27 2001-02-27
US60/271,793 2001-02-27
CA2438858A CA2438858C (en) 2001-02-27 2002-02-27 External mixer assembly

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2438858A Division CA2438858C (en) 2001-02-27 2002-02-27 External mixer assembly

Publications (1)

Publication Number Publication Date
CA2766682A1 true CA2766682A1 (en) 2002-09-06

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CA2766682A Abandoned CA2766682A1 (en) 2001-02-27 2002-02-27 External mixer assembly
CA2438858A Expired - Fee Related CA2438858C (en) 2001-02-27 2002-02-27 External mixer assembly

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2438858A Expired - Fee Related CA2438858C (en) 2001-02-27 2002-02-27 External mixer assembly

Country Status (7)

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US (1) US7018357B2 (en)
EP (2) EP1372488B1 (en)
AU (1) AU2002238143B2 (en)
CA (2) CA2766682A1 (en)
DE (2) DE60224990T2 (en)
ES (2) ES2328087T3 (en)
WO (1) WO2002067785A2 (en)

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DE60232926D1 (en) 2009-08-20
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DE60224990T2 (en) 2009-02-05
US7018357B2 (en) 2006-03-28

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