CA2796516C - Infusion bag with integrated rinsing system - Google Patents
Infusion bag with integrated rinsing system Download PDFInfo
- Publication number
- CA2796516C CA2796516C CA 2796516 CA2796516A CA2796516C CA 2796516 C CA2796516 C CA 2796516C CA 2796516 CA2796516 CA 2796516 CA 2796516 A CA2796516 A CA 2796516A CA 2796516 C CA2796516 C CA 2796516C
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- Prior art keywords
- compartment
- bag
- infusion
- rinsing solution
- medication
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
- A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
Abstract
The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or the leakage of residual medicament from the bag or line.
Description
INFUSION BAG WITH INTEGRATED RINSING SYSTEM
Background of the invention The present invention relates to the infusion of medication contained in a flexible bag, which flows into the veins of a patient via an infusion line, under the effect of gravity, the bag being suspended above the patient.
More particularly, the invention relates to a bag for medical use for infusing medication by gravity, comprising at least two compartments, one containing medication and the other containing a rinsing solution, and separation/communication means for automatically rinsing the medication bag and infusion line.
The invention is intended to solve, simply and inexpensively, two major problems encountered with this type of infusion, namely:
- the loss of some of the medication: The infusion line has a non-negligible volume, in particular in the case of small infusion bags. The amount of medication remaining in the line plus the residual amount contained in the bag is not infused into the patient who thus does not receive the prescribed dose;
- the risk of contamination due to the toxicity of the medication: the medication infused may be extremely toxic or allergenic (cancer medication, antibiotics, etc.) and there may be a risk of contamination when the care personnel purges the air from the perfusion line before connecting up to the patient or when disconnecting the infusion line.
Background of the invention The present invention relates to the infusion of medication contained in a flexible bag, which flows into the veins of a patient via an infusion line, under the effect of gravity, the bag being suspended above the patient.
More particularly, the invention relates to a bag for medical use for infusing medication by gravity, comprising at least two compartments, one containing medication and the other containing a rinsing solution, and separation/communication means for automatically rinsing the medication bag and infusion line.
The invention is intended to solve, simply and inexpensively, two major problems encountered with this type of infusion, namely:
- the loss of some of the medication: The infusion line has a non-negligible volume, in particular in the case of small infusion bags. The amount of medication remaining in the line plus the residual amount contained in the bag is not infused into the patient who thus does not receive the prescribed dose;
- the risk of contamination due to the toxicity of the medication: the medication infused may be extremely toxic or allergenic (cancer medication, antibiotics, etc.) and there may be a risk of contamination when the care personnel purges the air from the perfusion line before connecting up to the patient or when disconnecting the infusion line.
The solution to these two problems consists in rinsing the line before and after infusion and rinsing the bag after infusion using a harmless, inexpensive solution (isotonic sodium chloride for example).
Description of the prior art Devices are already known which can at least partially rinse the bag/line, limiting medication loss and the risks for care personnel.
Patent US 5 242 392 describes an infusion system comprising a chamber for a rinsing liquid connected to the infusion tubing between the medication bag and the injection device and located lower than the medication bag. When the medication has been administered, the rinsing solution rinses the infusion tubing and injection device automatically.
Patent FR 2 794 983 describes a closed-circuit infusion system comprising at least one medication bag and dispensing and infusion means, associated with a rinsing bag in such a way that the rinsing solution can flow through the dispensing and infusion means, and also selection means allowing the medication and/or the rinsing solution to flow through the dispensing and infusion means.
Patent FR 2 306 711 describes an infusion device comprising at least two infusion containers suspended at different heights, whose tubes are connected for example using a Y-shaped connection piece, and a valve device with two inlets whose operation is linked to the difference in height between the infusion containers which causes a difference in height between the columns of liquid.
Description of the prior art Devices are already known which can at least partially rinse the bag/line, limiting medication loss and the risks for care personnel.
Patent US 5 242 392 describes an infusion system comprising a chamber for a rinsing liquid connected to the infusion tubing between the medication bag and the injection device and located lower than the medication bag. When the medication has been administered, the rinsing solution rinses the infusion tubing and injection device automatically.
Patent FR 2 794 983 describes a closed-circuit infusion system comprising at least one medication bag and dispensing and infusion means, associated with a rinsing bag in such a way that the rinsing solution can flow through the dispensing and infusion means, and also selection means allowing the medication and/or the rinsing solution to flow through the dispensing and infusion means.
Patent FR 2 306 711 describes an infusion device comprising at least two infusion containers suspended at different heights, whose tubes are connected for example using a Y-shaped connection piece, and a valve device with two inlets whose operation is linked to the difference in height between the infusion containers which causes a difference in height between the columns of liquid.
Documents WO 92/11881, US 4 512 764, WO
95/09020, EP 0 790 064, US 4 623 334 and WO 03/077974 describe infusion or injection systems comprising devices for rinsing the infusion line or injection system.
These devices do not provide a satisfactory solution to the problems of safety and effectiveness of the infusion systems:
- If the bag contains air, it may be completely emptied but a relatively large part of the infusion line will contain air and the line cannot be rinsed since the air contained in the line would be injected in the patient (risk of air embolism). The presence of the nurse is therefore required before the end of infusion in order to carry out rinsing at the exact moment when the bag is completely emptied, before some of the line fills with air.
- If the bag does not contain air, it cannot be completely emptied and the residual liquid contained in the bag will not be injected into the patient. In this case, the line may be rinsed, but not the bag.
- In all cases, the intervention of the nurse is required, entailing extra work.
Summary of the invention The present invention is intended to improve the safety and effectiveness of infusion systems by virtue of a device for automatically rinsing the line and the bag after infusion, without the nurse's intervention.
The present invention relates to a bag for medical use for infusing medication by gravity, comprising at least two compartments, one containing medication in the form of a solution and the other(s) containing a rinsing solution, and compartment separation/communication means which allow the rinsing solution to enter the compartment containing the medication automatically only after infusion. The rinsing solution completes the infusion, rinsing the medication bag and the infusion line, thus eliminating the risk of contamination and the loss of residual medication in the bag and that contained in the infusion line.
The basic principle of the invention consists in using the vacuum created in the medication bag at the end of infusion owing to the water column height in the infusion line. This vacuum gradually increases at the end of infusion, as the bag becomes flattened through a "siphon"
effect. This vacuum can reach around -100 mb.
The rinsing liquid, which is at atmospheric pressure, is drawn into the compartment containing the medication, which in turn is at a vacuum pressure with respect to atmospheric pressure.
The separation/communication means comprise a breakable device between the compartment containing the medication and the compartment (one of the compartments) containing the solution and a device for ensuring automatic communication between the compartment containing the medication and the compartment containing the solution or between the two compartments containing the solution.
The device for ensuring automatic communication between the compartments may be a communication channel positioned above the level of the liquid in said compartments when the bag is suspended vertically.
95/09020, EP 0 790 064, US 4 623 334 and WO 03/077974 describe infusion or injection systems comprising devices for rinsing the infusion line or injection system.
These devices do not provide a satisfactory solution to the problems of safety and effectiveness of the infusion systems:
- If the bag contains air, it may be completely emptied but a relatively large part of the infusion line will contain air and the line cannot be rinsed since the air contained in the line would be injected in the patient (risk of air embolism). The presence of the nurse is therefore required before the end of infusion in order to carry out rinsing at the exact moment when the bag is completely emptied, before some of the line fills with air.
- If the bag does not contain air, it cannot be completely emptied and the residual liquid contained in the bag will not be injected into the patient. In this case, the line may be rinsed, but not the bag.
- In all cases, the intervention of the nurse is required, entailing extra work.
Summary of the invention The present invention is intended to improve the safety and effectiveness of infusion systems by virtue of a device for automatically rinsing the line and the bag after infusion, without the nurse's intervention.
The present invention relates to a bag for medical use for infusing medication by gravity, comprising at least two compartments, one containing medication in the form of a solution and the other(s) containing a rinsing solution, and compartment separation/communication means which allow the rinsing solution to enter the compartment containing the medication automatically only after infusion. The rinsing solution completes the infusion, rinsing the medication bag and the infusion line, thus eliminating the risk of contamination and the loss of residual medication in the bag and that contained in the infusion line.
The basic principle of the invention consists in using the vacuum created in the medication bag at the end of infusion owing to the water column height in the infusion line. This vacuum gradually increases at the end of infusion, as the bag becomes flattened through a "siphon"
effect. This vacuum can reach around -100 mb.
The rinsing liquid, which is at atmospheric pressure, is drawn into the compartment containing the medication, which in turn is at a vacuum pressure with respect to atmospheric pressure.
The separation/communication means comprise a breakable device between the compartment containing the medication and the compartment (one of the compartments) containing the solution and a device for ensuring automatic communication between the compartment containing the medication and the compartment containing the solution or between the two compartments containing the solution.
The device for ensuring automatic communication between the compartments may be a communication channel positioned above the level of the liquid in said compartments when the bag is suspended vertically.
As a variant, the device for ensuring automatic communication between the compartments may be a pressure-threshold valve.
The compartment or compartments containing the rinsing solution may comprise a narrow area towards the top of the bag.
Description of the drawings The attached drawings illustrate the present invention in more detail.
Figure 1 shows an infusion bag with two compartments comprising a communication channel.
Figure 2 shows an infusion bag with two compartments comprising a pressure-threshold valve.
Figure 3 is a cross section through the pressure-threshold valve of figure 2 with integrated breakable device in the closed state.
Figure 4 shows the same valve in the open state.
Figure 5 shows an infusion bag with three compartments comprising a communication channel.
Description of the preferred embodiments According to a first embodiment of the invention shown in figure 1, use is made of a flexible infusion bag separated into two juxtaposed compartments (1) and (2), one (1) of which contains the medication and the other (2) the rinsing solution. Compartment (1) comprises an access (4) for filling the bag and connecting to the infusion line (10). Compartment (2) comprises a narrow area (9) at the top of the bag and an access (5) for filling said compartment. The two compartments are separated by a substantially vertical wall (7) whose upper part comprises a breakable device (3) designed to ensure the seal between the two compartments when it is intact and to allow communication between the two compartments when it is broken by the nurse by mechanical intervention on the outside of the bag. This device is imperatively placed above the level of the liquids when the bag is suspended.
Compartments (1) and (2) are filled without the addition of air. Said compartments comprise means (8) and (6) for preventing the flow path of the liquid from being sealed up completely when the bag flattens. These means (8) and (6) may consist for example of a "roughening" of the surface of one of the faces of the bag or a thermoformed channel, which aid the flow.
According to a second embodiment of the invention shown in figure 2, use is made of a flexible infusion bag separated into two superposed compartments (1) and (2).
The two compartments are separated by a substantially horizontal wall (7) whose central part comprises a breakable device (3) broken by the nurse. In this embodiment, the flow of the rinsing solution from compartment (2) to compartment (1) is triggered by a pressure-threshold valve (11) as a function of the difference in pressure between the compartments (1) and (2).
Compartment (1) comprises means (8) for preventing the flow path of the liquid from being sealed up completely when the bag flattens. These means (8) facilitate the flow between the communication orifice between the two compartments and the access (4) to the infusion line (10).
According to a variant (not shown) of the bag of figure 1 or 2, use is made of two separate bags instead of one bag with two compartments.
Figures 3 and 4 show an example of the pressure-threshold valve used in the bag of figure 2.
The valve comprises two chambers (14) and (15) separated by an elastomer membrane (13). As shown in figure 3, the seal between the two chambers is ensured by the membrane (13) being pretensioned on the annular sealing ring (17).
The chamber (14) is in communication with compartment (2) containing the rinsing solution via the openings (12).
After the breakable device (3) is broken, the chamber (15) is in communication with the compartment (1) containing the medication.
As shown in figure 4, when the pressure inside the chamber (15) becomes negative with respect to the pressure in the chamber (14), the membrane (13) detaches from the annular sealing ring (17), thus allowing the rinsing liquid contained in compartment (2) to flow into compartment (1) via the orifice (16).
According to a third embodiment of the invention shown in figure 5, use is made of a flexible infusion bag separated into three juxtaposed compartments, allowing rinsing at the beginning and end of infusion. Compartment (1) contains the medication and is separated from compartments (2) and (2a) containing rinsing solution by a substantially vertical wall (7) whose lower part comprises a breakable device (3) broken by the nurse.
-Compartments (2) and (2a) are separated by a wall (19) leaving a passage (18) at the top of the bag which prevents the transfer of the contents from (2) into (2a) and/or the contents from (2a) into (2) if the bag is suspended vertically and if there is no difference in pressure between said compartments. Compartment (2a) comprises an access (4) to the infusion line (10). The volume of compartment (2a) is slightly greater than the volume of a standard infusion line (around 10 milliliters).
The following examples illustrate how the infusion bags of the invention are used.
Example 1: Bag with two juxtaposed compartments (figure 1) After the infusion line has been established, the nurse breaks the breakable device (3) by mechanical intervention on the outside of the flexible bag, to place the compartments (1) and (2) in communication without causing transfer since the pressure inside the two compartments is identical. When compartment (1) is practically empty, its walls collapse. The pressure in compartment (1) then becomes negative with respect to the pressure in compartment (2), which flattens, causing the rinsing liquid to rise into the communication channel between the two compartments. The rising liquid then empties into compartment (1), and then into the infusion line, thus rinsing the medication out of compartment (1) and the line (10). The patient will thus receive all the medication and the nurse will handle an infusion line and a bag free of toxic liquid.
Example 2: Bag with two superposed compartments (figure 2) The method of example 1 is followed, except that it is the pressure-threshold valve that allows the rinsing solution to flow into compartment (1) when the pressure in this compartment becomes negative with respect to the pressure in compartment (2).
Example 3: Bag with three juxtaposed compartments (figure 5) Once the bag has been connected up to the infusion line (10), the air-filled infusion line is in communication with compartment (2a) which is full of rinsing solution.
The nurse starts infusion as usual with the contents of compartment (2a). After this operation, compartment (2a) is almost empty.
The nurse connects the line to the patient, then breaks the breakable device (3). Compartment (1) is then in communication with compartment (2a) and thus with the infusion line (10). The medication contained in (1) flows into compartment (2a) until the heights of liquid in said compartments are equal.
When compartments (1) and (2a) are almost empty, the walls collapse, causing the rinsing solution in compartment (2) to be sucked into compartment (2a). After the levels between compartments (1) and (2a) have equaled out, which rinses the bottom of the compartment, the rinsing solution flows into the perfusion line (10).
The description and figures illustrate various embodiments of the present invention. However, the scope of the invention is limited by the appended claims.
The compartment or compartments containing the rinsing solution may comprise a narrow area towards the top of the bag.
Description of the drawings The attached drawings illustrate the present invention in more detail.
Figure 1 shows an infusion bag with two compartments comprising a communication channel.
Figure 2 shows an infusion bag with two compartments comprising a pressure-threshold valve.
Figure 3 is a cross section through the pressure-threshold valve of figure 2 with integrated breakable device in the closed state.
Figure 4 shows the same valve in the open state.
Figure 5 shows an infusion bag with three compartments comprising a communication channel.
Description of the preferred embodiments According to a first embodiment of the invention shown in figure 1, use is made of a flexible infusion bag separated into two juxtaposed compartments (1) and (2), one (1) of which contains the medication and the other (2) the rinsing solution. Compartment (1) comprises an access (4) for filling the bag and connecting to the infusion line (10). Compartment (2) comprises a narrow area (9) at the top of the bag and an access (5) for filling said compartment. The two compartments are separated by a substantially vertical wall (7) whose upper part comprises a breakable device (3) designed to ensure the seal between the two compartments when it is intact and to allow communication between the two compartments when it is broken by the nurse by mechanical intervention on the outside of the bag. This device is imperatively placed above the level of the liquids when the bag is suspended.
Compartments (1) and (2) are filled without the addition of air. Said compartments comprise means (8) and (6) for preventing the flow path of the liquid from being sealed up completely when the bag flattens. These means (8) and (6) may consist for example of a "roughening" of the surface of one of the faces of the bag or a thermoformed channel, which aid the flow.
According to a second embodiment of the invention shown in figure 2, use is made of a flexible infusion bag separated into two superposed compartments (1) and (2).
The two compartments are separated by a substantially horizontal wall (7) whose central part comprises a breakable device (3) broken by the nurse. In this embodiment, the flow of the rinsing solution from compartment (2) to compartment (1) is triggered by a pressure-threshold valve (11) as a function of the difference in pressure between the compartments (1) and (2).
Compartment (1) comprises means (8) for preventing the flow path of the liquid from being sealed up completely when the bag flattens. These means (8) facilitate the flow between the communication orifice between the two compartments and the access (4) to the infusion line (10).
According to a variant (not shown) of the bag of figure 1 or 2, use is made of two separate bags instead of one bag with two compartments.
Figures 3 and 4 show an example of the pressure-threshold valve used in the bag of figure 2.
The valve comprises two chambers (14) and (15) separated by an elastomer membrane (13). As shown in figure 3, the seal between the two chambers is ensured by the membrane (13) being pretensioned on the annular sealing ring (17).
The chamber (14) is in communication with compartment (2) containing the rinsing solution via the openings (12).
After the breakable device (3) is broken, the chamber (15) is in communication with the compartment (1) containing the medication.
As shown in figure 4, when the pressure inside the chamber (15) becomes negative with respect to the pressure in the chamber (14), the membrane (13) detaches from the annular sealing ring (17), thus allowing the rinsing liquid contained in compartment (2) to flow into compartment (1) via the orifice (16).
According to a third embodiment of the invention shown in figure 5, use is made of a flexible infusion bag separated into three juxtaposed compartments, allowing rinsing at the beginning and end of infusion. Compartment (1) contains the medication and is separated from compartments (2) and (2a) containing rinsing solution by a substantially vertical wall (7) whose lower part comprises a breakable device (3) broken by the nurse.
-Compartments (2) and (2a) are separated by a wall (19) leaving a passage (18) at the top of the bag which prevents the transfer of the contents from (2) into (2a) and/or the contents from (2a) into (2) if the bag is suspended vertically and if there is no difference in pressure between said compartments. Compartment (2a) comprises an access (4) to the infusion line (10). The volume of compartment (2a) is slightly greater than the volume of a standard infusion line (around 10 milliliters).
The following examples illustrate how the infusion bags of the invention are used.
Example 1: Bag with two juxtaposed compartments (figure 1) After the infusion line has been established, the nurse breaks the breakable device (3) by mechanical intervention on the outside of the flexible bag, to place the compartments (1) and (2) in communication without causing transfer since the pressure inside the two compartments is identical. When compartment (1) is practically empty, its walls collapse. The pressure in compartment (1) then becomes negative with respect to the pressure in compartment (2), which flattens, causing the rinsing liquid to rise into the communication channel between the two compartments. The rising liquid then empties into compartment (1), and then into the infusion line, thus rinsing the medication out of compartment (1) and the line (10). The patient will thus receive all the medication and the nurse will handle an infusion line and a bag free of toxic liquid.
Example 2: Bag with two superposed compartments (figure 2) The method of example 1 is followed, except that it is the pressure-threshold valve that allows the rinsing solution to flow into compartment (1) when the pressure in this compartment becomes negative with respect to the pressure in compartment (2).
Example 3: Bag with three juxtaposed compartments (figure 5) Once the bag has been connected up to the infusion line (10), the air-filled infusion line is in communication with compartment (2a) which is full of rinsing solution.
The nurse starts infusion as usual with the contents of compartment (2a). After this operation, compartment (2a) is almost empty.
The nurse connects the line to the patient, then breaks the breakable device (3). Compartment (1) is then in communication with compartment (2a) and thus with the infusion line (10). The medication contained in (1) flows into compartment (2a) until the heights of liquid in said compartments are equal.
When compartments (1) and (2a) are almost empty, the walls collapse, causing the rinsing solution in compartment (2) to be sucked into compartment (2a). After the levels between compartments (1) and (2a) have equaled out, which rinses the bottom of the compartment, the rinsing solution flows into the perfusion line (10).
The description and figures illustrate various embodiments of the present invention. However, the scope of the invention is limited by the appended claims.
Claims (8)
1. A bag for medical use for infusing medication by gravity, comprising :
- at least a first compartment, a second compartment and a third compartment, the first compartment configured to contain medication in the form of a solution, the third compartment configured to contain a first rinsing solution, and the second compartment configured to contain a second rinsing solution, wherein the first compartment, the second compartment and the third compartment are juxtaposed, - a first separation/communication portion that separates the first compartment and the third compartment, wherein the first separation/communication portion comprises a breakable device disposed between the first and the third compartment, the breakable device being disposed at a bottom end of the first separation/communication portion when the bag is suspended vertically, and - a second separation/communication portion that separates the second compartment and the third compartment, wherein the second separation/communication portion comprises a communication channel disposed at an end of the bag that is above the second compartment when the bag is suspended vertically, and - an access port for an infusion line disposed at a bottom portion of the third compartment when the bag is suspended vertically, wherein the breakable device prevents communication between the first compartment and the third compartment when not broken, and the breakable device allows communication between the first compartment and the third compartment when broken, wherein if the breakable device is broken, the medication is capable of flowing into the third compartment and flowing into the infusion line via the third compartment, and wherein the second rinsing solution is capable of flowing into the third compartment via the communication channel and flowing into the infusion line, after the first compartment and the third compartment are almost emptied, wherein the communication channel having an output side disposed at a height that substantially prevents the second rinsing solution from entering the third compartment until after the first compartment and the third compartment are almost emptied of the medication solution, and wherein the second separation/communication portion is configured to allow the second rinsing solution to automatically flow into the third compartment via the communication channel when a pressure in the first compartment and the third compartment becomes negative with respect to a pressure in the second compartment under a siphon effect created by a fluid column height in the infusion line.
- at least a first compartment, a second compartment and a third compartment, the first compartment configured to contain medication in the form of a solution, the third compartment configured to contain a first rinsing solution, and the second compartment configured to contain a second rinsing solution, wherein the first compartment, the second compartment and the third compartment are juxtaposed, - a first separation/communication portion that separates the first compartment and the third compartment, wherein the first separation/communication portion comprises a breakable device disposed between the first and the third compartment, the breakable device being disposed at a bottom end of the first separation/communication portion when the bag is suspended vertically, and - a second separation/communication portion that separates the second compartment and the third compartment, wherein the second separation/communication portion comprises a communication channel disposed at an end of the bag that is above the second compartment when the bag is suspended vertically, and - an access port for an infusion line disposed at a bottom portion of the third compartment when the bag is suspended vertically, wherein the breakable device prevents communication between the first compartment and the third compartment when not broken, and the breakable device allows communication between the first compartment and the third compartment when broken, wherein if the breakable device is broken, the medication is capable of flowing into the third compartment and flowing into the infusion line via the third compartment, and wherein the second rinsing solution is capable of flowing into the third compartment via the communication channel and flowing into the infusion line, after the first compartment and the third compartment are almost emptied, wherein the communication channel having an output side disposed at a height that substantially prevents the second rinsing solution from entering the third compartment until after the first compartment and the third compartment are almost emptied of the medication solution, and wherein the second separation/communication portion is configured to allow the second rinsing solution to automatically flow into the third compartment via the communication channel when a pressure in the first compartment and the third compartment becomes negative with respect to a pressure in the second compartment under a siphon effect created by a fluid column height in the infusion line.
2. The bag according to claim 1, wherein the second compartment comprises a narrow area at the top of the bag.
3. The bag according to claim 1, further comprising means for preventing the flow path of the second rinsing solution from being sealed completely when the bag flattens.
4. The bag according to claim 3, wherein said means for preventing the flow path of the second rinsing solution from being sealed completely comprises a roughening of the surface of at least one of the faces of the bag.
5. The bag according to claim 3, wherein said means for preventing the flow path of the second rinsing solution from being sealed completely comprises a thermoformed channel.
6. The bag according to claim 1, wherein the bag is flexible.
7. The bag according to claim 1, wherein the first compartment and the third compartment are separated by a substantially vertical wall.
8. The bag according to claim 1, wherein the third compartment and the second compartment are separated by a substantially vertical wall.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR04/05919 | 2004-06-02 | ||
| FR0405919A FR2871062B1 (en) | 2004-06-02 | 2004-06-02 | INFUSION POCKET WITH INTEGRATED RINSE |
| CA2568138A CA2568138C (en) | 2004-06-02 | 2005-06-02 | Infusion bag with integrated rinsing system |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2568138A Division CA2568138C (en) | 2004-06-02 | 2005-06-02 | Infusion bag with integrated rinsing system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2796516A1 CA2796516A1 (en) | 2006-02-23 |
| CA2796516C true CA2796516C (en) | 2015-04-07 |
Family
ID=34949083
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2796516 Expired - Fee Related CA2796516C (en) | 2004-06-02 | 2005-06-02 | Infusion bag with integrated rinsing system |
| CA2568138A Expired - Fee Related CA2568138C (en) | 2004-06-02 | 2005-06-02 | Infusion bag with integrated rinsing system |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2568138A Expired - Fee Related CA2568138C (en) | 2004-06-02 | 2005-06-02 | Infusion bag with integrated rinsing system |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7722594B1 (en) |
| EP (2) | EP2210631A3 (en) |
| JP (2) | JP4861980B2 (en) |
| KR (1) | KR101190275B1 (en) |
| CN (1) | CN100577227C (en) |
| AT (1) | ATE484271T1 (en) |
| AU (1) | AU2005273807A1 (en) |
| BR (1) | BRPI0511742A2 (en) |
| CA (2) | CA2796516C (en) |
| CY (1) | CY1111424T1 (en) |
| DE (1) | DE602005024130D1 (en) |
| DK (1) | DK1753487T3 (en) |
| ES (1) | ES2353240T3 (en) |
| FR (1) | FR2871062B1 (en) |
| IL (1) | IL179542A (en) |
| MX (1) | MXPA06013925A (en) |
| NO (1) | NO20065516L (en) |
| PL (1) | PL1753487T3 (en) |
| PT (1) | PT1753487E (en) |
| RU (1) | RU2373961C2 (en) |
| SI (1) | SI1753487T1 (en) |
| UA (1) | UA93656C2 (en) |
| WO (1) | WO2006018555A1 (en) |
| ZA (1) | ZA200609940B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5202005B2 (en) * | 2008-01-22 | 2013-06-05 | テルモ株式会社 | Liquid recovery bag and extracorporeal circuit |
| US8698741B1 (en) | 2009-01-16 | 2014-04-15 | Fresenius Medical Care Holdings, Inc. | Methods and apparatus for medical device cursor control and touchpad-based navigation |
| US10799117B2 (en) | 2009-11-05 | 2020-10-13 | Fresenius Medical Care Holdings, Inc. | Patient treatment and monitoring systems and methods with cause inferencing |
| US9585810B2 (en) * | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
| CN104717992B (en) * | 2012-10-12 | 2018-11-09 | 史密斯医疗Asd公司 | Drug or fluid delivery system |
| FR2999938B1 (en) | 2012-12-21 | 2015-02-06 | Maco Pharma Sa | INFUSION SYSTEM FOR ADMINISTERING A SOLUTION AND RINSING THE SAID SYSTEM |
| ES1106455Y (en) * | 2014-01-23 | 2014-07-10 | Servicio Andaluz De Salud | DOUBLE SERUM BAG |
| CN104739646A (en) * | 2015-03-27 | 2015-07-01 | 朱小菊 | Safe no-residue infusion bottle plug |
| EP3195845A1 (en) | 2016-01-21 | 2017-07-26 | B. Braun Melsungen AG | Pharmacy bag with integrated flush option |
| US10507966B2 (en) * | 2016-11-06 | 2019-12-17 | Innovationary Enterprises LLC | Straw accessible multiple compartment beverage pouch |
| FR3060302A1 (en) * | 2016-12-15 | 2018-06-22 | Technoflex | MEDICAL POCKET FOR INTEGRATED RINSING |
| FR3068611B1 (en) * | 2017-07-10 | 2022-01-07 | Maco Pharma Sa | INFUSION SYSTEM FOR THE ADMINISTRATION OF A SOLUTION AND THE FLUSHING OF THE SAID SYSTEM |
| DE102018251757A1 (en) * | 2018-12-27 | 2020-07-02 | Eurozyto Gmbh | Bags for the provision of a medicinal active ingredient and set with bags and transfer system |
| US11712388B2 (en) * | 2020-03-10 | 2023-08-01 | The Regents Of The University Of Michigan | Device for blood loss measurement following childbirth to detect postpartum hemorrhage |
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| US2887109A (en) * | 1956-06-04 | 1959-05-19 | Wayland D Keith | Single use, disposable douche apparatus |
| US3217711A (en) * | 1963-08-01 | 1965-11-16 | Abbott Lab | Valve apparatus for sequentially administering parenteral fluid from separate sources |
| US4324238A (en) * | 1979-02-28 | 1982-04-13 | Abbott Laboratories | Equipment sets having a combined air barrier and liquid sequencing device for the sequential administration of medical liquids at dual flow rates |
| DE3019636C2 (en) * | 1979-06-08 | 1983-03-31 | Panpack AG, 9490 Vaduz | Disposable packaging for storing and dispensing small amounts of flowable materials |
| US4248226A (en) * | 1979-10-11 | 1981-02-03 | Pitchford Jr Robert L | Automatic douche mechanism |
| US4396383A (en) * | 1981-11-09 | 1983-08-02 | Baxter Travenol Laboratories, Inc. | Multiple chamber solution container including positive test for homogenous mixture |
| US4496046A (en) * | 1983-09-15 | 1985-01-29 | Baxter Travenol Laboratories, Inc. | Multiple chamber container with inner diaphragm and intermediate chamber |
| DE3624319A1 (en) * | 1986-07-18 | 1988-01-28 | Wolff Walsrode Ag | METHOD FOR PRODUCING POLYURETHANE FILMS FOR BLOOD OR INFUSION BAGS |
| IL82619A0 (en) * | 1987-05-21 | 1987-11-30 | Migada Ltd | Infusion apparatus |
| CH686778A5 (en) | 1987-05-29 | 1996-06-28 | Vifor Medical Ag | Container for separate storage of active compounds and their subsequent mixing. |
| US4997093A (en) * | 1989-06-07 | 1991-03-05 | Letteri Jr Vincent E | Item drying device |
| US4994056A (en) * | 1989-11-09 | 1991-02-19 | Ikeda Daniel P | Unit dose medicament storing and mixing system |
| US5076933A (en) * | 1990-06-29 | 1991-12-31 | Coulter Corporation | Process and apparatus for removal of dna and viruses |
| EP0564567A1 (en) * | 1990-12-27 | 1993-10-13 | Block Medical, Inc. | Closed system for iv site flush |
| SE9103395D0 (en) * | 1991-11-18 | 1991-11-18 | Gambro Ab | SYSTEM USING ENSTERIL MEDICAL SOLUTION CONTAINING GLUCOSE OR GLUCOSE-LIKE SUBSTANCES AND A SOLUTION INTENDED FOR THIS SYSTEM |
| US5242392A (en) * | 1992-02-13 | 1993-09-07 | Vaughn Dale T | Intravenous piggyback flush apparatus |
| CA2094102A1 (en) * | 1992-04-30 | 1993-10-31 | David S. Utterberg | Blood air trap chamber |
| WO1994016664A1 (en) * | 1993-01-19 | 1994-08-04 | Baxter International Inc. | Multiple chamber container |
| DE9401288U1 (en) * | 1994-01-26 | 1994-03-17 | Fresenius Ag | Multi-chamber bags |
| US6655837B2 (en) * | 1998-05-29 | 2003-12-02 | Toyo Seikan Kaisha, Ltd. | Pouch having a branched chamber |
| FR2794983B1 (en) * | 1999-06-18 | 2001-12-28 | Maco Pharma Sa | MULTIPLE POCKET PERFUSION KIT |
| FR2808784B1 (en) * | 2000-05-10 | 2002-07-26 | Oreal | DEVICE FOR DISPENSING A COMPOSITION WITH A CONCENTRATION GRADIENT |
| JP2003159308A (en) * | 2001-11-27 | 2003-06-03 | Nihon Pharmaceutical Co Ltd | Medical bag |
| US6752264B2 (en) * | 2002-07-03 | 2004-06-22 | Sonoco Development, Inc. | Flexible pouch having system for mixing two components |
| US7055683B2 (en) * | 2002-12-20 | 2006-06-06 | E. I. Du Pont De Nemours And Company | Multiple compartment pouch and beverage container with smooth curve frangible seal |
-
2004
- 2004-06-02 FR FR0405919A patent/FR2871062B1/en active Active
-
2005
- 2005-02-06 UA UAA200612704A patent/UA93656C2/en unknown
- 2005-06-02 BR BRPI0511742-9A patent/BRPI0511742A2/en not_active IP Right Cessation
- 2005-06-02 KR KR1020067026351A patent/KR101190275B1/en not_active IP Right Cessation
- 2005-06-02 CA CA 2796516 patent/CA2796516C/en not_active Expired - Fee Related
- 2005-06-02 SI SI200531204T patent/SI1753487T1/en unknown
- 2005-06-02 DK DK05826796.4T patent/DK1753487T3/en active
- 2005-06-02 US US11/597,381 patent/US7722594B1/en not_active Expired - Fee Related
- 2005-06-02 DE DE602005024130T patent/DE602005024130D1/en active Active
- 2005-06-02 PL PL05826796T patent/PL1753487T3/en unknown
- 2005-06-02 CN CN200580017710A patent/CN100577227C/en not_active Expired - Fee Related
- 2005-06-02 PT PT05826796T patent/PT1753487E/en unknown
- 2005-06-02 EP EP20100162139 patent/EP2210631A3/en not_active Withdrawn
- 2005-06-02 CA CA2568138A patent/CA2568138C/en not_active Expired - Fee Related
- 2005-06-02 ES ES05826796T patent/ES2353240T3/en active Active
- 2005-06-02 EP EP05826796A patent/EP1753487B1/en not_active Not-in-force
- 2005-06-02 AT AT05826796T patent/ATE484271T1/en active
- 2005-06-02 RU RU2006142181A patent/RU2373961C2/en not_active IP Right Cessation
- 2005-06-02 WO PCT/FR2005/050414 patent/WO2006018555A1/en active Application Filing
- 2005-06-02 AU AU2005273807A patent/AU2005273807A1/en not_active Abandoned
- 2005-06-02 MX MXPA06013925A patent/MXPA06013925A/en unknown
- 2005-06-02 JP JP2007514061A patent/JP4861980B2/en not_active Expired - Fee Related
-
2006
- 2006-11-23 IL IL179542A patent/IL179542A/en not_active IP Right Cessation
- 2006-11-28 ZA ZA200609940A patent/ZA200609940B/en unknown
- 2006-11-29 NO NO20065516A patent/NO20065516L/en not_active Application Discontinuation
-
2010
- 2010-04-08 US US12/756,837 patent/US7938816B2/en not_active Expired - Fee Related
- 2010-12-24 JP JP2010287623A patent/JP5075974B2/en not_active Expired - Fee Related
-
2011
- 2011-01-11 CY CY20111100031T patent/CY1111424T1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20121109 |
|
| MKLA | Lapsed |
Effective date: 20160602 |