CA2805425A1 - Ophthalmic drug delivery - Google Patents
Ophthalmic drug delivery Download PDFInfo
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- CA2805425A1 CA2805425A1 CA2805425A CA2805425A CA2805425A1 CA 2805425 A1 CA2805425 A1 CA 2805425A1 CA 2805425 A CA2805425 A CA 2805425A CA 2805425 A CA2805425 A CA 2805425A CA 2805425 A1 CA2805425 A1 CA 2805425A1
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H15/00—ICT specially adapted for medical reports, e.g. generation or transmission thereof
Abstract
Description
OPHTHALMIC DRUG DELIVERY
Related Applications The present application claims the benefit of the filing date of U.S. Provisional Application No. 61/400,864, filed July 15, 2010, U.S. Provisional Application No. 61/401,850, filed August 20, 2010, U.S. Provisional Application No. 61/401,920 filed August 20, 2010, U.S. Provisional Application No. 61/401,918 filed August 20, 2010, U.S.
Provisional Application No. 61/401,848 filed August 20, 2010, U.S. Provisional Application No.
61/401,849 filed August 20, 2010, U.S. Provisional Application No. 61/462,576 filed February 4, 2011, U.S. Provisional Application No. 61/462,791 filed February 5, 2011, U.S. Provisional Application No. 61/463,280 filed February 15, 2011, U.S. Provisional Application No.
61/516,462, filed April 4, 2011, U.S. Provisional Application No. 61/516,496 filed April 4, 2011, U.S. Provisional Application No. 61/516,495 filed April 4, 2011, and U.S. Provisional Application No. 61/516,694, filed April 6, 2011, the entire contents of each of which is specifically hereby incorporated by reference for all purposes. The present application is also related to U.S. Provisional Application No. 61/396,531 filed May 28, 2010, the entire contents of which is specifically hereby incorporated by reference for all purposes.
Field of the Invention The present invention relates to devices for the generation of ejected droplets, methods of administration and uses thereof, and medicament compositions formulated therefor.
Background of the Invention A typical medical droplet as dispensed by an eye dropper bottle can vary, depending on the viscosity and surface tension of the fluid. In order to control the amount of active ingredient that is administered in a single droplet, the concentration of the active ingredient is adjusted by volume. Once the concentration is defined, a correct dosage may require one drop or more. However, since the human eye can typically retain only 7 1 of fluid at a time, even a single medical droplet can result in overflow and loss of part of the medication from the eye.
Multiple drop dosage often compounds the problem of medication retention in the eye.
Subjects will typically administer all droplets required for a dosage in one sitting, which exacerbates the problem and can result in 50 to 90% of the medication overflowing and leaking out of the eye.
Another further problem is that a single droplet of the defined concentration marks the lower limit of a dose and, as such, the amount of active ingredient that can be administered at the defined concentration. For example, pediatric application where lower doses are often advisable are an illustration of where the size/dose of a droplet can be problematic.
Given the above and other limitations of current ophthalmic delivery, a need exists for an efficient delivery system for solutions to the eye, including solutions containing medicaments.
Summary of the Invention To address such needs and others, provided herein are stable medicament compositions and uses thereof.
One embodiment provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament, where said droplets have an average drop size of between about 15 microns and about 100 microns in diameters and an average ejecting velocity of between about 0.5 m/s to about 20 m/s; and (b) delivering the medicament to the eye, where between about 80% to about 100% of the ejected mass of the droplets are deposited on the eye.
Another embodiment provides a method of delivering a medicament solution to a subject in need thereof by controlling droplet size and droplet deposit parameters of the medicament solution, the method comprising: (a) determining desired dosage of the medicament solution for the subject in need thereof; and (b) providing the desired dosage in a single application by determining the droplet size and deposit parameters.
Yet another embodiment provides a method for providing a solution to the eye, the method comprising: (a) providing droplets containing the medicament, having an average droplet size of between about 15 microns and about 100 microns in diameter and an average initial ejecting velocity of between about 0.5 m/s to about 20 m/s; and (b) delivering the medicament to the eye, where between about 80% to about 100% of the ejected mass of the droplets are deposited on the eye.
These and other aspects of the invention will become apparent to one of skill in the art.
Related Applications The present application claims the benefit of the filing date of U.S. Provisional Application No. 61/400,864, filed July 15, 2010, U.S. Provisional Application No. 61/401,850, filed August 20, 2010, U.S. Provisional Application No. 61/401,920 filed August 20, 2010, U.S. Provisional Application No. 61/401,918 filed August 20, 2010, U.S.
Provisional Application No. 61/401,848 filed August 20, 2010, U.S. Provisional Application No.
61/401,849 filed August 20, 2010, U.S. Provisional Application No. 61/462,576 filed February 4, 2011, U.S. Provisional Application No. 61/462,791 filed February 5, 2011, U.S. Provisional Application No. 61/463,280 filed February 15, 2011, U.S. Provisional Application No.
61/516,462, filed April 4, 2011, U.S. Provisional Application No. 61/516,496 filed April 4, 2011, U.S. Provisional Application No. 61/516,495 filed April 4, 2011, and U.S. Provisional Application No. 61/516,694, filed April 6, 2011, the entire contents of each of which is specifically hereby incorporated by reference for all purposes. The present application is also related to U.S. Provisional Application No. 61/396,531 filed May 28, 2010, the entire contents of which is specifically hereby incorporated by reference for all purposes.
Field of the Invention The present invention relates to devices for the generation of ejected droplets, methods of administration and uses thereof, and medicament compositions formulated therefor.
Background of the Invention A typical medical droplet as dispensed by an eye dropper bottle can vary, depending on the viscosity and surface tension of the fluid. In order to control the amount of active ingredient that is administered in a single droplet, the concentration of the active ingredient is adjusted by volume. Once the concentration is defined, a correct dosage may require one drop or more. However, since the human eye can typically retain only 7 1 of fluid at a time, even a single medical droplet can result in overflow and loss of part of the medication from the eye.
Multiple drop dosage often compounds the problem of medication retention in the eye.
Subjects will typically administer all droplets required for a dosage in one sitting, which exacerbates the problem and can result in 50 to 90% of the medication overflowing and leaking out of the eye.
Another further problem is that a single droplet of the defined concentration marks the lower limit of a dose and, as such, the amount of active ingredient that can be administered at the defined concentration. For example, pediatric application where lower doses are often advisable are an illustration of where the size/dose of a droplet can be problematic.
Given the above and other limitations of current ophthalmic delivery, a need exists for an efficient delivery system for solutions to the eye, including solutions containing medicaments.
Summary of the Invention To address such needs and others, provided herein are stable medicament compositions and uses thereof.
One embodiment provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament, where said droplets have an average drop size of between about 15 microns and about 100 microns in diameters and an average ejecting velocity of between about 0.5 m/s to about 20 m/s; and (b) delivering the medicament to the eye, where between about 80% to about 100% of the ejected mass of the droplets are deposited on the eye.
Another embodiment provides a method of delivering a medicament solution to a subject in need thereof by controlling droplet size and droplet deposit parameters of the medicament solution, the method comprising: (a) determining desired dosage of the medicament solution for the subject in need thereof; and (b) providing the desired dosage in a single application by determining the droplet size and deposit parameters.
Yet another embodiment provides a method for providing a solution to the eye, the method comprising: (a) providing droplets containing the medicament, having an average droplet size of between about 15 microns and about 100 microns in diameter and an average initial ejecting velocity of between about 0.5 m/s to about 20 m/s; and (b) delivering the medicament to the eye, where between about 80% to about 100% of the ejected mass of the droplets are deposited on the eye.
These and other aspects of the invention will become apparent to one of skill in the art.
2 Detailed Description of the Invention A. Methods of Generating Ejected Droplets The present invention provides an effective approach to undertake dosing strategies.
Dosing strategies also will incorporate various approaches to initiating treatment, stopping treatment, switching treatment and responding to different subject states.
Examples of dosing modes or strategies include night time administration, administration before waking, increased administration one week a month, three times a day, continuous dosing, bolus dosing, taper dosing, need-based dosing, and feedback dosing by the physician, provider, subject or family. The clinical scenarios where these can be employed include chronic disease, disease exacerbation, need for suppression treatment, need for recurrence treatment, or state of treatment like medicament tolerance.
B. Methods of Delivery and Treatment Provided is a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Devices capable of providing and delivering a fluid such as ophthalmic fluid to the eye are provided. In certain aspects, ejection devices include an ejection assembly which generates or provides a controllable stream of droplets of fluid. Fluids include, without limitation, suspensions and emulsions which have viscosity in a range capable of droplet formation using an ejector mechanism. As explained in further detail herein, in accordance with certain aspects of the present disclosure, the actuator mechanism may form a directed stream of droplets, which may be directed toward a target. The droplets will be formed in distribution of sizes, each distribution having an average droplet size. The average droplet size may be in the range of about 15 microns to about 100 microns, about 20 microns to about 100 microns, greater than 20 microns to about 100 microns, about 20 microns to about 80 microns, about 25 microns to about 75 microns, about 30 microns to about 60 microns, about 35 microns to about 55 microns, etc. However, the average droplet size may be as large as 2500 microns, depending on the intended application. Further, the droplets may have an average initial ejecting velocity of about 0.5 m/s to about 20 m/s, e.g., about 1 m/s to about 10 m/s, about 1 m/s to about 5 m/s, about 1 m/s to about 4 m/s, about 2 m/s, etc. As used herein, the ejecting size and the ejecting initial velocity are the size and velocity of the droplets when the droplets leave the ejector plate.
Dosing strategies also will incorporate various approaches to initiating treatment, stopping treatment, switching treatment and responding to different subject states.
Examples of dosing modes or strategies include night time administration, administration before waking, increased administration one week a month, three times a day, continuous dosing, bolus dosing, taper dosing, need-based dosing, and feedback dosing by the physician, provider, subject or family. The clinical scenarios where these can be employed include chronic disease, disease exacerbation, need for suppression treatment, need for recurrence treatment, or state of treatment like medicament tolerance.
B. Methods of Delivery and Treatment Provided is a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Devices capable of providing and delivering a fluid such as ophthalmic fluid to the eye are provided. In certain aspects, ejection devices include an ejection assembly which generates or provides a controllable stream of droplets of fluid. Fluids include, without limitation, suspensions and emulsions which have viscosity in a range capable of droplet formation using an ejector mechanism. As explained in further detail herein, in accordance with certain aspects of the present disclosure, the actuator mechanism may form a directed stream of droplets, which may be directed toward a target. The droplets will be formed in distribution of sizes, each distribution having an average droplet size. The average droplet size may be in the range of about 15 microns to about 100 microns, about 20 microns to about 100 microns, greater than 20 microns to about 100 microns, about 20 microns to about 80 microns, about 25 microns to about 75 microns, about 30 microns to about 60 microns, about 35 microns to about 55 microns, etc. However, the average droplet size may be as large as 2500 microns, depending on the intended application. Further, the droplets may have an average initial ejecting velocity of about 0.5 m/s to about 20 m/s, e.g., about 1 m/s to about 10 m/s, about 1 m/s to about 5 m/s, about 1 m/s to about 4 m/s, about 2 m/s, etc. As used herein, the ejecting size and the ejecting initial velocity are the size and velocity of the droplets when the droplets leave the ejector plate.
3 The stream of droplets directed at a target will result in deposition of a percentage of the mass of the droplets including their composition onto the desired location.
The disclosed technology will eject droplets without substantial evaporation, entrainment of air, or deflection off the eye surface, which facilitates consistent dosing.
Average ejecting droplet size and average initial ejecting velocity are dependent on factors including fluid viscosity, surface tension, ejector plate properties, geometry, and dimensions, as well as operating parameters of the piezoelectric actuator including its drive frequency. In some implementations, about 60% to about 100%, about 65% to about 100%, about 75% to about 100%, about 80% to about 100%, about 85% to about 100%, about 90% to about 100%, about 95% to about 100%, etc., of the ejected mass of droplets are deposited on the surface of the eye, such deposition being repeatable independent of operating and use conditions. The direction of flow of the stream of droplets may be horizontal, or any direction a user chooses to aim the actuation mechanism during use.
Droplet performance is generally related to particle diameter. Without intending to be limited, ejected droplets are slowed to a stop by air drag (i.e., stopping distance of the ejected droplets). Ejected droplets also fall vertically due to gravity. After a short acceleration time, the droplets reach terminal velocity where the drag force equals the force of gravity. The ejected droplets may carry air along with them, which creates an entrained airstream, which aids to then carry the ejected droplets beyond the calculated stopping distance. However, increased levels of entrained air may cause the ejected droplets to flow across an impact surface (e.g., an eye surface) because the entrained airflow must turn 90 degrees at such a surface.
Small, ejected droplets (e.g., droplets having an average diameter less than about 17 microns, less than about 15 microns, etc.) are carried along the surface of the eye by the airstream and may not impact the surface. Contrasted to this, larger ejected droplets create less entrained air than an equivalent mass of smaller droplets, and have enough momentum to impact the surface.
The ejected droplet stopping distance is a measure of this effect.
Also provided is a method of delivering a medicament solution to a subject in need thereof by controlling droplet size and deposit parameters of the medicament solution, the method comprising: (a) determining desired dosage of the medicament solution for the subject in need thereof; and (b) providing the desired dosage in a single application or multiple applications by determining the droplet size and deposit parameters.
Many factors, including those described herein, can influence the desired dosage. Once the desired dosage is determined, and also if desired frequency, such doses can be delivered.
Frequency of dosing can vary by number of times, periodicity or both.
The disclosed technology will eject droplets without substantial evaporation, entrainment of air, or deflection off the eye surface, which facilitates consistent dosing.
Average ejecting droplet size and average initial ejecting velocity are dependent on factors including fluid viscosity, surface tension, ejector plate properties, geometry, and dimensions, as well as operating parameters of the piezoelectric actuator including its drive frequency. In some implementations, about 60% to about 100%, about 65% to about 100%, about 75% to about 100%, about 80% to about 100%, about 85% to about 100%, about 90% to about 100%, about 95% to about 100%, etc., of the ejected mass of droplets are deposited on the surface of the eye, such deposition being repeatable independent of operating and use conditions. The direction of flow of the stream of droplets may be horizontal, or any direction a user chooses to aim the actuation mechanism during use.
Droplet performance is generally related to particle diameter. Without intending to be limited, ejected droplets are slowed to a stop by air drag (i.e., stopping distance of the ejected droplets). Ejected droplets also fall vertically due to gravity. After a short acceleration time, the droplets reach terminal velocity where the drag force equals the force of gravity. The ejected droplets may carry air along with them, which creates an entrained airstream, which aids to then carry the ejected droplets beyond the calculated stopping distance. However, increased levels of entrained air may cause the ejected droplets to flow across an impact surface (e.g., an eye surface) because the entrained airflow must turn 90 degrees at such a surface.
Small, ejected droplets (e.g., droplets having an average diameter less than about 17 microns, less than about 15 microns, etc.) are carried along the surface of the eye by the airstream and may not impact the surface. Contrasted to this, larger ejected droplets create less entrained air than an equivalent mass of smaller droplets, and have enough momentum to impact the surface.
The ejected droplet stopping distance is a measure of this effect.
Also provided is a method of delivering a medicament solution to a subject in need thereof by controlling droplet size and deposit parameters of the medicament solution, the method comprising: (a) determining desired dosage of the medicament solution for the subject in need thereof; and (b) providing the desired dosage in a single application or multiple applications by determining the droplet size and deposit parameters.
Many factors, including those described herein, can influence the desired dosage. Once the desired dosage is determined, and also if desired frequency, such doses can be delivered.
Frequency of dosing can vary by number of times, periodicity or both.
4 Also provided is a method for providing a solution to the eye, the method comprising:
(a) providing droplets containing the solution, where the droplets have an average drop size in diameter and an average initial ejecting velocity; and (b) delivering the solution to the eye, where between about 80% to about 100% of the ejected mass of the droplets are deposited on the eye.
Further provided is a method of treating eye condition disorders, including glaucoma, infection or other eye indications, and related discomforts or other need in a subject in need thereof, the method comprising: (a) providing droplets containing said medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Further provided is a method of providing a reduced dosage form of a medicament to an eye comprising: (a) providing droplets containing the medicament, where the droplets have an average drop size and an average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a specified deposited mass of the droplets. In this or other aspects, the droplets can provide a total volume of less than 30 1, 20 1, 15 1, 10 ul, 5 1 or 2 1 to eye.
C. Ejector Device Exemplary ejector devices capable of generating droplets of the type described herein are provided in US Application Attorney Docket No. 24591.003-US03, filed concurrently herewith, entitled Drop-Generating Device, herein incorporated by reference in its entirety. In one aspect of one such device an ejector plate is coupled to an actuator. The manner and location of attachment of the actuator to the plate affects the operation of the ejection assembly and the creation of the droplet stream with the option of the actuator being a piezoelectric actuator.
D. Medicament and Other Compositions Any medicament showing a desired ophthalmic activity may be administered. In an aspect, the medicament is available by prescription. In another aspect, the medicament is available over-the-counter. In an aspect, the medicament is or comprises a biologic agent. In an aspect, the biologic agent is selected from the group consisting of a full-length antibody, an active fragment of a full-length antibody, a peptide, a pegylated peptide, and an enzymatic ingredient. In another aspect, the biologic ingredient is selected from the group consisting of bevacizumab, ranibizumab, FV fragments, bi-specific antibodies, fusion molecules, pegaptanib, plasmin and microplasmin. In a further aspect, the biologic agent is selected from the group
(a) providing droplets containing the solution, where the droplets have an average drop size in diameter and an average initial ejecting velocity; and (b) delivering the solution to the eye, where between about 80% to about 100% of the ejected mass of the droplets are deposited on the eye.
Further provided is a method of treating eye condition disorders, including glaucoma, infection or other eye indications, and related discomforts or other need in a subject in need thereof, the method comprising: (a) providing droplets containing said medicament with a specified average size and average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a percentage of the ejected mass of the droplets to the eye.
Further provided is a method of providing a reduced dosage form of a medicament to an eye comprising: (a) providing droplets containing the medicament, where the droplets have an average drop size and an average initial ejecting velocity; and (b) delivering the medicament to the eye, where the droplets deliver a specified deposited mass of the droplets. In this or other aspects, the droplets can provide a total volume of less than 30 1, 20 1, 15 1, 10 ul, 5 1 or 2 1 to eye.
C. Ejector Device Exemplary ejector devices capable of generating droplets of the type described herein are provided in US Application Attorney Docket No. 24591.003-US03, filed concurrently herewith, entitled Drop-Generating Device, herein incorporated by reference in its entirety. In one aspect of one such device an ejector plate is coupled to an actuator. The manner and location of attachment of the actuator to the plate affects the operation of the ejection assembly and the creation of the droplet stream with the option of the actuator being a piezoelectric actuator.
D. Medicament and Other Compositions Any medicament showing a desired ophthalmic activity may be administered. In an aspect, the medicament is available by prescription. In another aspect, the medicament is available over-the-counter. In an aspect, the medicament is or comprises a biologic agent. In an aspect, the biologic agent is selected from the group consisting of a full-length antibody, an active fragment of a full-length antibody, a peptide, a pegylated peptide, and an enzymatic ingredient. In another aspect, the biologic ingredient is selected from the group consisting of bevacizumab, ranibizumab, FV fragments, bi-specific antibodies, fusion molecules, pegaptanib, plasmin and microplasmin. In a further aspect, the biologic agent is selected from the group
5
6 consisting of ranibizumab antibody FAB ( including LucentisTm), VEGF Trap fusion molecule (including VEGF Trap-EyeTm), microplasmin enzyme (including OcriplasminTm), macugen pegylated polypeptide (including PegaptanibTm), and bevacizumab (including AvastinTm).
In another aspect, a medicament to be administered is or comprises a small molecule. In an aspect, the medicament to be administered comprises a medicament selected from the group consisting of cyclosporine, neomycin, biomonidine, and aminoglycoside antibiotics, including, for example, tobramycin and gentamycin.
In various aspects, a solution may have different salinity. Salinity may be measured using a hydrometer. In various aspects, salinity may range from 0%, or a pure aqueous solution, to 2.5%. In other aspects, salinity may range from about 0.1% to about 1%, from about 0.5% to about 1%, from about 0.7% to about 1%, from about 0.8% to about 1%. In further aspects, salinity of a medicament may be about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, or about 1.5%. In other aspects, salinity may be less than about 1.5%, less than about 1%, less than about 0.5% or less than about 0.2%. In an aspect, the solution is isotonic with the site of delivery. For example, in various aspects, the medicament may be isotonic with human tears, blood, or eye tissue.
In an aspect, the medicament to be delivered comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HC1, pheniramine maleate, ketotifen fumarate, oxymetazoline HC1, naphazoline HC1, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost. In another aspect, the medicament is selected from the group consisting of Refresh TearsTm, Visine Advanced ReliefTM, Naphcon ATM, Sensitive Eyes, RenuTM, Opti-freeTM rewetting drops, Visine A.C.
TM, Hypo tearsTM, AlawayTM , Visine L.R. , VismeTM original, Rohto Coorm, Soothe XPTM,= TM = =
ZaditorTM, Bausch & Lomb Advanced Eye Relief RednessTm, Visine ATM, Opcon-A, Walgreens artificial tears, VisineTM dry eye relief, Advanced Eye Relief Dry EyeTM, Opti-free ReplenishTM, Clear EyesTM redness relief, VigamoxTM, BromdayTM, DurezolTM, ZymaxidTm, Travatan Zrm, TropicamideTm, BepreveTm, ZymarTM, LotemaxTm, Istalorm, PatadayTm, AK-DilateTM, Toradorm, XalatanTm, and LumiganTM.
In another aspect, the medicament to be delivered comprises a medicament selected from the group consisting of fluorosilicone acrylate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HC1, carboxymethylcellulose sodium, propylene glycol, hypromellose, zinc sulfate, dorzolamide HC1 timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, dorzolamide HC1, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine. In a further aspect, the medicament is selected from the group consisting of Tears Naturale II, Optimum NWNTm, Thera Tears, Systane UltraTM, GenTearm, Systane Lubricant Eye DrOP5TM, BlinkTM
tears, Visine Max Redness ReliefTM, Refresh OptiveTM, MurO128TM, Systane BalanceTM, Rohto HydraTM, Rohto Ice, Walgreens sterile artificial tears, Rohto Arctic, Clear Eyes Tm natural tears lubricant, SimilasanTM pink eye relief, SimilasanTm allergy eye relief, CO5OPtTM, AzaSiteTm, Alphagan PTm, NevanacTM, AzoptTm, BesivanceTm, TrusoptTm, AlrexTM, and RestasisTM.
In an aspect, an ophthalmic medicament to be delivered is used to treat glaucoma. In an aspect, a glaucoma medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HC1 timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HC1, and BAK free latanoprost. In a further aspect, a medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, and BAK free latanoprost. In another aspect, a medicament is selected from the group consisting of dorzolamide HC1 timolol maleate, brimonidine tartrate, brinzolamide, and dorzolamide HC1. In an aspect, a glaucoma medicament is selected from the group consisting of TravatanTm, Istalorm, XalatanTm, LumiganTM, CO5OPtTM, Alphagan PTm, AzoptTM, and TrusoptTm. In another aspect, a medicament is selected from the group consisting of TravatanTm, Istolorm, XalatanTm, and LumiganTM. In a further aspect, a medicament is selected from the group consisting of CO5OPtTM, Alphagan PTm, AzoptTM, and Dorzolamide HC1TM.
In an aspect, the concentration of an active ingredient in a medicament is measured as a percentage of the active ingredient in solution. In an aspect, the concentration of active ingredient ranges from about 0.0001% to about 5%. In another aspect, the concentration of active ingredient in a medicament ranges from about 0.0005% to about 1%. In other aspects, the concentration of active ingredient ranges from about 0.0005% to about 0.0001%, from about 0.0001% to about 0.001%, or from about 0.0005% to about 0.001%. In other aspects, the concentration of active ingredient ranges from about 0.005% to about 0.001% or from about 0.001% to about 0.01%. In another aspect, the concentration of active ingredient ranges from about 0.001% to about 0.5%. In various other aspects, the concentration of active ingredient is selected from the group consisting of about 0.0001%, about 0.0005%, about 0.001%, about 0.0025%, about 0.005%, about 0.01%, about 0.025%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.75%, about 1%, about 1.5%, about 2%, about
In another aspect, a medicament to be administered is or comprises a small molecule. In an aspect, the medicament to be administered comprises a medicament selected from the group consisting of cyclosporine, neomycin, biomonidine, and aminoglycoside antibiotics, including, for example, tobramycin and gentamycin.
In various aspects, a solution may have different salinity. Salinity may be measured using a hydrometer. In various aspects, salinity may range from 0%, or a pure aqueous solution, to 2.5%. In other aspects, salinity may range from about 0.1% to about 1%, from about 0.5% to about 1%, from about 0.7% to about 1%, from about 0.8% to about 1%. In further aspects, salinity of a medicament may be about 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, or about 1.5%. In other aspects, salinity may be less than about 1.5%, less than about 1%, less than about 0.5% or less than about 0.2%. In an aspect, the solution is isotonic with the site of delivery. For example, in various aspects, the medicament may be isotonic with human tears, blood, or eye tissue.
In an aspect, the medicament to be delivered comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HC1, pheniramine maleate, ketotifen fumarate, oxymetazoline HC1, naphazoline HC1, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost. In another aspect, the medicament is selected from the group consisting of Refresh TearsTm, Visine Advanced ReliefTM, Naphcon ATM, Sensitive Eyes, RenuTM, Opti-freeTM rewetting drops, Visine A.C.
TM, Hypo tearsTM, AlawayTM , Visine L.R. , VismeTM original, Rohto Coorm, Soothe XPTM,= TM = =
ZaditorTM, Bausch & Lomb Advanced Eye Relief RednessTm, Visine ATM, Opcon-A, Walgreens artificial tears, VisineTM dry eye relief, Advanced Eye Relief Dry EyeTM, Opti-free ReplenishTM, Clear EyesTM redness relief, VigamoxTM, BromdayTM, DurezolTM, ZymaxidTm, Travatan Zrm, TropicamideTm, BepreveTm, ZymarTM, LotemaxTm, Istalorm, PatadayTm, AK-DilateTM, Toradorm, XalatanTm, and LumiganTM.
In another aspect, the medicament to be delivered comprises a medicament selected from the group consisting of fluorosilicone acrylate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HC1, carboxymethylcellulose sodium, propylene glycol, hypromellose, zinc sulfate, dorzolamide HC1 timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, dorzolamide HC1, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine. In a further aspect, the medicament is selected from the group consisting of Tears Naturale II, Optimum NWNTm, Thera Tears, Systane UltraTM, GenTearm, Systane Lubricant Eye DrOP5TM, BlinkTM
tears, Visine Max Redness ReliefTM, Refresh OptiveTM, MurO128TM, Systane BalanceTM, Rohto HydraTM, Rohto Ice, Walgreens sterile artificial tears, Rohto Arctic, Clear Eyes Tm natural tears lubricant, SimilasanTM pink eye relief, SimilasanTm allergy eye relief, CO5OPtTM, AzaSiteTm, Alphagan PTm, NevanacTM, AzoptTm, BesivanceTm, TrusoptTm, AlrexTM, and RestasisTM.
In an aspect, an ophthalmic medicament to be delivered is used to treat glaucoma. In an aspect, a glaucoma medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HC1 timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HC1, and BAK free latanoprost. In a further aspect, a medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, and BAK free latanoprost. In another aspect, a medicament is selected from the group consisting of dorzolamide HC1 timolol maleate, brimonidine tartrate, brinzolamide, and dorzolamide HC1. In an aspect, a glaucoma medicament is selected from the group consisting of TravatanTm, Istalorm, XalatanTm, LumiganTM, CO5OPtTM, Alphagan PTm, AzoptTM, and TrusoptTm. In another aspect, a medicament is selected from the group consisting of TravatanTm, Istolorm, XalatanTm, and LumiganTM. In a further aspect, a medicament is selected from the group consisting of CO5OPtTM, Alphagan PTm, AzoptTM, and Dorzolamide HC1TM.
In an aspect, the concentration of an active ingredient in a medicament is measured as a percentage of the active ingredient in solution. In an aspect, the concentration of active ingredient ranges from about 0.0001% to about 5%. In another aspect, the concentration of active ingredient in a medicament ranges from about 0.0005% to about 1%. In other aspects, the concentration of active ingredient ranges from about 0.0005% to about 0.0001%, from about 0.0001% to about 0.001%, or from about 0.0005% to about 0.001%. In other aspects, the concentration of active ingredient ranges from about 0.005% to about 0.001% or from about 0.001% to about 0.01%. In another aspect, the concentration of active ingredient ranges from about 0.001% to about 0.5%. In various other aspects, the concentration of active ingredient is selected from the group consisting of about 0.0001%, about 0.0005%, about 0.001%, about 0.0025%, about 0.005%, about 0.01%, about 0.025%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.75%, about 1%, about 1.5%, about 2%, about
7 2.5%, about 3%, about 4%, and about 5% measured as a percentage of the solution. However, given the lower dosing amounts afforded by the methods of the present disclosure, higher concentrations may be used depending on the intended use. For examples, about 10%, about 20%, about 25%, of the active ingredient in the medicament, measured as a percentage of the solution, may be utilized.
In an aspect, the medicament comprises a medicament selected from the group consisting of between about 0.02% and about 0.03% carboxymethylcellulose sodium, between about 0.4% and about 0.6% carboxymethylcellulose sodium, between about 0.04%
and about 0.06% tetrahydrozoline HC1, between about 0.04% and about 0.06%
tetrahydrozoline HC1, between about 0.24% and about 0.36% pheniramine maleate, between about 0.02%
and about 0.03% ketotifen fumarate, between about 0.028% and about 0.042% ketotifen fumarate, between about 0.02% and about 0.03% oxymetazoline HC1, between about 0.0096%
and about 0.0144% naphazoline HC1, between about 0.024% and about 0.036% naphazoline HC1, between about 0.24% and 0.36% pheniramine maleate, between about 0.4% and about 0.6%
moxifloxacin hydrochloride, between about 0.072% and about 0.108% bromfenac, between about 0.4% and about 0.6% proparacaine hydrochloride, between about 0.04% and about 0.06%
difluprednate, between about 0.4% and about 0.6% gatifloxacin, between about 0.0032% and about 0.0048% travoprost, between about 1.2% and about 1.8% bepotastine besilate, between about 0.24% and about 0.36% gatifloxacin, between about 0.4% and about 0.6%
loteprednol etabonate, between about 0.4% and about 0.6% timolol ophthalmic, between about 0.16% and about 0.24% olopatadine hydrochloride, between about 2% and about 3%
phenylephrine hydrochloride, between about 0.4% and about 0.6% levofloxacin, between about 0.32% and about 0.48% ketorolac tromethamine, between about 0.004% and about 0.006%
letanoprost, and between about 0.024% and about 0.036% bimatoprost.
In an aspect, the medicament comprises a medicament selected from the group consisting of 0.025% carboxymethylcellulose sodium, 0.5%
carboxymethylcellulose sodium, 0.05% tetrahydrozoline HC1, 0.5%, tetrahydrozoline HC1, 0.3% pheniramine maleate, 0.025%
ketotifen fumarate, 0.035% ketotifen fumarate, 0.025% oxymetazoline HC1, 0.012%
naphazoline HC1, 0.03% naphazoline HC1, 0.3% pheniramine maleate, 0.5%
moxifloxacin hydrochloride, 0.09% bromfenac, 0.5% proparacaine hydrochloride, 0.05%
difluprednate, 0.5%
gatifloxacin, 0.004% travoprost, 1.5% bepotastine besilate, 0.3% gatifloxacin, 0.5% loteprednol etabonate,0.5% timolol ophthalmic, 0.2% olopatadine hydrochloride, 2.5%
phenylephrine hydrochloride, 0.5% levofloxacin, 0.4% ketorolac tromethamine, 0.005%
letanoprost, and 0.03% bimatoprost.
In an aspect, the medicament comprises a medicament selected from the group consisting of between about 0.02% and about 0.03% carboxymethylcellulose sodium, between about 0.4% and about 0.6% carboxymethylcellulose sodium, between about 0.04%
and about 0.06% tetrahydrozoline HC1, between about 0.04% and about 0.06%
tetrahydrozoline HC1, between about 0.24% and about 0.36% pheniramine maleate, between about 0.02%
and about 0.03% ketotifen fumarate, between about 0.028% and about 0.042% ketotifen fumarate, between about 0.02% and about 0.03% oxymetazoline HC1, between about 0.0096%
and about 0.0144% naphazoline HC1, between about 0.024% and about 0.036% naphazoline HC1, between about 0.24% and 0.36% pheniramine maleate, between about 0.4% and about 0.6%
moxifloxacin hydrochloride, between about 0.072% and about 0.108% bromfenac, between about 0.4% and about 0.6% proparacaine hydrochloride, between about 0.04% and about 0.06%
difluprednate, between about 0.4% and about 0.6% gatifloxacin, between about 0.0032% and about 0.0048% travoprost, between about 1.2% and about 1.8% bepotastine besilate, between about 0.24% and about 0.36% gatifloxacin, between about 0.4% and about 0.6%
loteprednol etabonate, between about 0.4% and about 0.6% timolol ophthalmic, between about 0.16% and about 0.24% olopatadine hydrochloride, between about 2% and about 3%
phenylephrine hydrochloride, between about 0.4% and about 0.6% levofloxacin, between about 0.32% and about 0.48% ketorolac tromethamine, between about 0.004% and about 0.006%
letanoprost, and between about 0.024% and about 0.036% bimatoprost.
In an aspect, the medicament comprises a medicament selected from the group consisting of 0.025% carboxymethylcellulose sodium, 0.5%
carboxymethylcellulose sodium, 0.05% tetrahydrozoline HC1, 0.5%, tetrahydrozoline HC1, 0.3% pheniramine maleate, 0.025%
ketotifen fumarate, 0.035% ketotifen fumarate, 0.025% oxymetazoline HC1, 0.012%
naphazoline HC1, 0.03% naphazoline HC1, 0.3% pheniramine maleate, 0.5%
moxifloxacin hydrochloride, 0.09% bromfenac, 0.5% proparacaine hydrochloride, 0.05%
difluprednate, 0.5%
gatifloxacin, 0.004% travoprost, 1.5% bepotastine besilate, 0.3% gatifloxacin, 0.5% loteprednol etabonate,0.5% timolol ophthalmic, 0.2% olopatadine hydrochloride, 2.5%
phenylephrine hydrochloride, 0.5% levofloxacin, 0.4% ketorolac tromethamine, 0.005%
letanoprost, and 0.03% bimatoprost.
8 In another aspect, the medicament to be delivered comprises a medicament selected from the group consisting of between about 0.02% and about 0.3% sodium carboxymethylcellulose, between about 0.04% and about 0.06% tetrahydrozoline HC1, between about 0.4% and about 0.6% carboxymethylcellulose sodium, between about 0.48%
and about 0.72% propylene glycol, between about 0.24% and about 0.36% hypromellose, between about 0.2% and about 0.3% zinc sulfate, between about 0.8% and about 1.2%
azithromycin, between about 0.08% and about 0.12% brimonidine tartrate, between about 0.08% and about 0.12%
nepafenac, between about 0.8% and about 1.2% brinzolamide, between about 0.48%
and about 0.72% besifloxacin, between about 1.6% and about 2.4% dorzolamide HC1, between about 0.8% and about 1.2% prenisone acetate, between about 0.16% and about 0.24%
loteprednol etabonate, between about 0.32% and about 0.48% tobramycin/dexamethasone, and between about 0.04% and about 0.06% cyclosporine.
In another aspect, the medicament to be delivered comprises a medicament selected from the group consisting of 0.025% sodium carboxymethylcellulose, 0.05%
tetrahydrozoline HC1, 0.5% carboxymethylcellulose sodium, 0.6% propylene glycol, 0.3%
hypromellose, 0.25%
zinc sulfate, 1% azithromycin, 0.1% brimonidine tartrate, 0.1% nepafenac, 1%
brinzolamide, 0.6% besifloxacin, 2% dorzolamide HC1, 1% prenisone acetate, 0.2% loteprednol etabonate, 0.4% tobramycin/dexamethasone, and 0.05% cyclosporine.
In an aspect, the medicament to be administered is not water-soluble. In another aspect, the medicament to be administered is poorly water-soluble. In a preferred aspect, the medicament is water-soluble, highly water-soluble, or very highly water-soluble. In an aspect, poorly water soluble is less than lOug/mL. In other aspects, water soluble is 10 to 60 ug/mL, highly water soluble is greater than 60 to 120 ug/mL, and very highly water soluble is greater than 120 ug/mL.In another aspect, the medicament to be administered is formulated in an emulsion or a suspension. In an aspect, the medicament to be delivered comprises difluprednate or loteprednol etabonate. In an aspect, the medicament is DurezolTm or LotemaxTM.
As generally understood by those skilled in the art, the listing of an active agent includes medicamently acceptable salts, esters, and acids thereof.
In an aspect, a medicament to be delivered comprises a preservative or other additive acceptable for use in the eye. In an aspect, a medicament comprises 20% or less of a preservative or other additive, or 15% or less, 12% or less, 10% or less, 8%
or less, 6% or less, 5% or less, 4% or less, 3% or less, 2% or less, 1% or less, 0.5% or less, 0.4%
or less, 0.3% or less, 0.2% or less, 0.1% or less of a preservative or other additive.
and about 0.72% propylene glycol, between about 0.24% and about 0.36% hypromellose, between about 0.2% and about 0.3% zinc sulfate, between about 0.8% and about 1.2%
azithromycin, between about 0.08% and about 0.12% brimonidine tartrate, between about 0.08% and about 0.12%
nepafenac, between about 0.8% and about 1.2% brinzolamide, between about 0.48%
and about 0.72% besifloxacin, between about 1.6% and about 2.4% dorzolamide HC1, between about 0.8% and about 1.2% prenisone acetate, between about 0.16% and about 0.24%
loteprednol etabonate, between about 0.32% and about 0.48% tobramycin/dexamethasone, and between about 0.04% and about 0.06% cyclosporine.
In another aspect, the medicament to be delivered comprises a medicament selected from the group consisting of 0.025% sodium carboxymethylcellulose, 0.05%
tetrahydrozoline HC1, 0.5% carboxymethylcellulose sodium, 0.6% propylene glycol, 0.3%
hypromellose, 0.25%
zinc sulfate, 1% azithromycin, 0.1% brimonidine tartrate, 0.1% nepafenac, 1%
brinzolamide, 0.6% besifloxacin, 2% dorzolamide HC1, 1% prenisone acetate, 0.2% loteprednol etabonate, 0.4% tobramycin/dexamethasone, and 0.05% cyclosporine.
In an aspect, the medicament to be administered is not water-soluble. In another aspect, the medicament to be administered is poorly water-soluble. In a preferred aspect, the medicament is water-soluble, highly water-soluble, or very highly water-soluble. In an aspect, poorly water soluble is less than lOug/mL. In other aspects, water soluble is 10 to 60 ug/mL, highly water soluble is greater than 60 to 120 ug/mL, and very highly water soluble is greater than 120 ug/mL.In another aspect, the medicament to be administered is formulated in an emulsion or a suspension. In an aspect, the medicament to be delivered comprises difluprednate or loteprednol etabonate. In an aspect, the medicament is DurezolTm or LotemaxTM.
As generally understood by those skilled in the art, the listing of an active agent includes medicamently acceptable salts, esters, and acids thereof.
In an aspect, a medicament to be delivered comprises a preservative or other additive acceptable for use in the eye. In an aspect, a medicament comprises 20% or less of a preservative or other additive, or 15% or less, 12% or less, 10% or less, 8%
or less, 6% or less, 5% or less, 4% or less, 3% or less, 2% or less, 1% or less, 0.5% or less, 0.4%
or less, 0.3% or less, 0.2% or less, 0.1% or less of a preservative or other additive.
9 In another aspect, the medicament to be delivered comprises a polymeric ingredient. In an aspect, the medicament comprises an additive selected from the group consisting of glycerin, castor oil, carbomer, polyethylene glycol, and polysorbate 80. In an aspect, the concentration of polymer is measured as a percentage of the total solution by weight. In various aspects, the medicament comprises 10% or less of a polymer, 5% or less of a polymer, 4% or less of a polymer, 3% or less of a polymer, 2% or less of a polymer, 1.5% or less of a polymer, 1% or less of a polymer, 0.5% or less of a polymer, 0.4% or less of a polymer, 0.3%
or less of a polymer, 0.2% or less of a polymer, 0.1% or less of a polymer, 0.05% or less of a polymer, or no detectable polymer. In various aspects, the medicament comprises 10% or less glycerin, 5%
or less glycerin, 4% or less glycerin, 3% or less glycerin, 2% or less glycerin, 1.5% or less glycerin, 1% or less glycerin, 0.5% or less glycerin, 0.4% or less glycerin, 0.3% or less glycerin, 0.2% or less glycerin, 0.1% or less glycerin, 0.05% or less glycerin, or no glycerin.
In various aspects, the medicament may have different tonicity. Tonicity may be measured using a hydrometer. In various aspects, tonicity may range from 0%, or a pure aqueous solution, to 2.5%. In other aspects, tonicity may range from 0.1% to 1%, from 0.5% to 1%, from 0.7% to 1%, from 0.8% to 1%. In further aspects, tonicity of a medicament may be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, or 1.5%. In an aspect, the medicament is isotonic with the site of delivery. For example, in various aspects, the medicament may be isotonic with human tears, blood, or eye tissue. It is contemplated that a solution with no active ingredient can be administered, e.g., a wetting agent.
In an aspect, the subject is less than 150 kilograms, 100 kilograms, less than kilograms, less than 25 kilograms, or less than 10 kilograms. In this or other aspects, the subject may be less than 12 or 13 years old. In this or other aspects, the subject could be classified as human, male or female. In this or other aspects, the subject may be an agricultural animal. In this or other aspects, the subject may be non-human.
The viscosity of the medicament to be administered can vary. Viscosity of a medicament formulation can be measured by using a viscometer. In various aspects, viscosity of a medicament at 25 C ranges from about 0.3 to about 300 cP, from about 0.3 to about 200 cP, from about 0.3 to about 100 cP, from about 0.3 to about 50 cP, from about 0.3 to about 40 cP, from about 0.3 to about 30 cP, from about 0.3 to about 20 cP, from about 0.3 to about 10 cP, from about 0.3 to about 5 cP, from about 0.3 to about 2 cP, from about 0.3 to about 1.5 cP, from about 0.3 to about 1 cP, from about 0.3 to about 0.9 cP, from about 0.3 to about 0.8 cP, from about 0.3 to about 0.7 cP from about 0.3 to about 0.6 cP, from about 0.3 to about 0.5 cP, or
or less of a polymer, 0.2% or less of a polymer, 0.1% or less of a polymer, 0.05% or less of a polymer, or no detectable polymer. In various aspects, the medicament comprises 10% or less glycerin, 5%
or less glycerin, 4% or less glycerin, 3% or less glycerin, 2% or less glycerin, 1.5% or less glycerin, 1% or less glycerin, 0.5% or less glycerin, 0.4% or less glycerin, 0.3% or less glycerin, 0.2% or less glycerin, 0.1% or less glycerin, 0.05% or less glycerin, or no glycerin.
In various aspects, the medicament may have different tonicity. Tonicity may be measured using a hydrometer. In various aspects, tonicity may range from 0%, or a pure aqueous solution, to 2.5%. In other aspects, tonicity may range from 0.1% to 1%, from 0.5% to 1%, from 0.7% to 1%, from 0.8% to 1%. In further aspects, tonicity of a medicament may be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, or 1.5%. In an aspect, the medicament is isotonic with the site of delivery. For example, in various aspects, the medicament may be isotonic with human tears, blood, or eye tissue. It is contemplated that a solution with no active ingredient can be administered, e.g., a wetting agent.
In an aspect, the subject is less than 150 kilograms, 100 kilograms, less than kilograms, less than 25 kilograms, or less than 10 kilograms. In this or other aspects, the subject may be less than 12 or 13 years old. In this or other aspects, the subject could be classified as human, male or female. In this or other aspects, the subject may be an agricultural animal. In this or other aspects, the subject may be non-human.
The viscosity of the medicament to be administered can vary. Viscosity of a medicament formulation can be measured by using a viscometer. In various aspects, viscosity of a medicament at 25 C ranges from about 0.3 to about 300 cP, from about 0.3 to about 200 cP, from about 0.3 to about 100 cP, from about 0.3 to about 50 cP, from about 0.3 to about 40 cP, from about 0.3 to about 30 cP, from about 0.3 to about 20 cP, from about 0.3 to about 10 cP, from about 0.3 to about 5 cP, from about 0.3 to about 2 cP, from about 0.3 to about 1.5 cP, from about 0.3 to about 1 cP, from about 0.3 to about 0.9 cP, from about 0.3 to about 0.8 cP, from about 0.3 to about 0.7 cP from about 0.3 to about 0.6 cP, from about 0.3 to about 0.5 cP, or
10 from about 0.3 to about 0.4 cP. In various other aspects, viscosity of a medicament to be administered is about 0.4 to about 1.4 cP, about 0.5 to about 1.3 cP, about 0.6 to about 1.2 cP, about 0.7 to about 1.1 cP, or about 0.8 to about 1.0 cP at room 25 C. In various other aspects, viscosity of a medicament at 25 C is about 0.3 cP, about 0.4 cP, about 0.5 cP, about 0.6 cP, about 0.7 cP, about 0.8 cP, about 0.9 cP, about 1 cP, about 1.1 cP, about 1.2 cP, about 1.3 cP, about 1.4 cP, or about 1.5 cP.
In some aspects, the active agents may exhibit increased stability and/or solubility at acid or alkaline pH and may be centrally administered in such form. In other aspects, a physiologically suitable pH (e.g., in the range of about pH 6.8-8.2, depending on the part of the eye) may be preferred for ophthalmic administration. However, titration to physiological pH
may result in solubility and/or stability issues for many active agents.
Therefore, it may be preferred in some cases to develop aqueous formulations in which the active agent is formulated with a solubility-enhancing agent or stabilizing excipients at a physiologically suitable pH. If titration is desired, any suitable buffer known in the medicament arts may be used (e.g., phosphate, acetate, glycine, citrate, imidazole, TRIS, MES, MOPS).
Further it may be desirable to maintain physiological isotonicity. For instance, in certain aspects, an osmolality ranging from about 100 to about 1000 mmol/kg, more particularly from about 280 to about 320 mmol/kg may be desired. Any suitable manner of adjusting tonicity known in the pharmaceutical arts may be used, e.g., adjustment with NaCl.
In accordance with certain aspects of the invention, medicament compositions are designed to maximize solubility and stability in ophthalmic applications and under conditions of use for administration to the eye.
1. Solubility Enhancing Agents Again, in accordance with certain aspects of the invention, formulation active agents in aqueous solutions at physiological pH and tonicity are undertaken. However, to provide adequate solubility to the composition, the use of solubility enhancing agents may optionally be required.
Without intending to be limited by theory, in certain aspects, solubility enhancing agents may utilize their amphiphilic characteristics to increase the solubility of active agents in water.
As generally understood by those skilled in the art, a wide variety of solubility enhancing agents that possess both nonpolar and hydrophilic moieties may be employed in connection with the present invention. However, amphiphilic agents possessing stronger hydrophobic character have the potential to interact with cell membranes and produce toxic effects.
Therefore, again, without intending to be limited by theory, solubility enhancing agents with
In some aspects, the active agents may exhibit increased stability and/or solubility at acid or alkaline pH and may be centrally administered in such form. In other aspects, a physiologically suitable pH (e.g., in the range of about pH 6.8-8.2, depending on the part of the eye) may be preferred for ophthalmic administration. However, titration to physiological pH
may result in solubility and/or stability issues for many active agents.
Therefore, it may be preferred in some cases to develop aqueous formulations in which the active agent is formulated with a solubility-enhancing agent or stabilizing excipients at a physiologically suitable pH. If titration is desired, any suitable buffer known in the medicament arts may be used (e.g., phosphate, acetate, glycine, citrate, imidazole, TRIS, MES, MOPS).
Further it may be desirable to maintain physiological isotonicity. For instance, in certain aspects, an osmolality ranging from about 100 to about 1000 mmol/kg, more particularly from about 280 to about 320 mmol/kg may be desired. Any suitable manner of adjusting tonicity known in the pharmaceutical arts may be used, e.g., adjustment with NaCl.
In accordance with certain aspects of the invention, medicament compositions are designed to maximize solubility and stability in ophthalmic applications and under conditions of use for administration to the eye.
1. Solubility Enhancing Agents Again, in accordance with certain aspects of the invention, formulation active agents in aqueous solutions at physiological pH and tonicity are undertaken. However, to provide adequate solubility to the composition, the use of solubility enhancing agents may optionally be required.
Without intending to be limited by theory, in certain aspects, solubility enhancing agents may utilize their amphiphilic characteristics to increase the solubility of active agents in water.
As generally understood by those skilled in the art, a wide variety of solubility enhancing agents that possess both nonpolar and hydrophilic moieties may be employed in connection with the present invention. However, amphiphilic agents possessing stronger hydrophobic character have the potential to interact with cell membranes and produce toxic effects.
Therefore, again, without intending to be limited by theory, solubility enhancing agents with
11 minimal hydrophobic character may be preferred in certain aspects within the context of the present invention, as such agents will be well-tolerated.
In addition to minimizing the hydrophobic character of the solubilizing agents employed, toxicity during administration may be reduced if the solubility enhancing agent is readily degraded in a cellular environment. The ability of cells to degrade compounds prevents their accumulation during chronic administration. To this end, the solubility enhancing agents may optionally include chemically-labile ester and ether linkages that contribute to low toxicity, and thereby prevent significant cellular accumulations during chronic administration.
In this regard, in accordance with certain aspects of the invention, the solubility-enhancing agent includes those that can be selected from cyclodextrins, e.g., 13-hydroxypropyl-cyclodextrin, sulfobutyl-ether- 0 cyclodextrin, etc.
In other aspects, the solubility-enhancing agent may be selected from sucrose esters.
Such agents are formed of two benign components (sucrose and fatty acids) linked by a highly labile ester bond. Although a readily-degradable linkage is beneficial from a toxicity standpoint, the solubility enhancing agent must be sufficiently robust to maintain its ability to solubilize the active agent during the desired conditions of use.
Generally, certain compositions of the invention may be prepared by formulating the desired amount, which may be a therapeutically-effective amount, of the desired active agent in a suitable solubility enhancing agent. Solubility enhancing agents include, but are not limited to, e.g., cyclodextrins, octylglucoside, pluronic F-68, Tween 20, sucrose esters, glycerol, ethylene glycol, alcohols, propylene glycol, carboxy methyl cellulose, solutol, mixtures thereof, etc. Other solubility-enhancing agents include, but are not limited to, polyethylene glycol (PEG), polyvinlypyrrolidone (PVP), arginine, proline, betaine, polyamino acids, peptides, nucleotides, sorbitol, sodium dodecylsulphate (SDS), sugar esters, other surfactants, other detergents and pluronics, and mixtures thereof. Alternatively, stable multiphase systems could be employed to safely solubilize therapeutics for intrathecal delivery (e.g., liposomes, micro/nano emulsions, nanoparticles, dendrimers, micro/nano spheres).
Any suitable amount of solubility enhancing agent sufficient to solubilize the active agent of interest to the desired concentration may be used. In certain aspects, molar ratios of active agent to solubility-enhancing agent ranging from about 0.5:1 to about 1:10, particularly, about 1:1 to about 1:5, more particularly 1:1 to about 1:2, may be used to achieve adequate solubility of the active agent to the desired concentrations.
In addition to minimizing the hydrophobic character of the solubilizing agents employed, toxicity during administration may be reduced if the solubility enhancing agent is readily degraded in a cellular environment. The ability of cells to degrade compounds prevents their accumulation during chronic administration. To this end, the solubility enhancing agents may optionally include chemically-labile ester and ether linkages that contribute to low toxicity, and thereby prevent significant cellular accumulations during chronic administration.
In this regard, in accordance with certain aspects of the invention, the solubility-enhancing agent includes those that can be selected from cyclodextrins, e.g., 13-hydroxypropyl-cyclodextrin, sulfobutyl-ether- 0 cyclodextrin, etc.
In other aspects, the solubility-enhancing agent may be selected from sucrose esters.
Such agents are formed of two benign components (sucrose and fatty acids) linked by a highly labile ester bond. Although a readily-degradable linkage is beneficial from a toxicity standpoint, the solubility enhancing agent must be sufficiently robust to maintain its ability to solubilize the active agent during the desired conditions of use.
Generally, certain compositions of the invention may be prepared by formulating the desired amount, which may be a therapeutically-effective amount, of the desired active agent in a suitable solubility enhancing agent. Solubility enhancing agents include, but are not limited to, e.g., cyclodextrins, octylglucoside, pluronic F-68, Tween 20, sucrose esters, glycerol, ethylene glycol, alcohols, propylene glycol, carboxy methyl cellulose, solutol, mixtures thereof, etc. Other solubility-enhancing agents include, but are not limited to, polyethylene glycol (PEG), polyvinlypyrrolidone (PVP), arginine, proline, betaine, polyamino acids, peptides, nucleotides, sorbitol, sodium dodecylsulphate (SDS), sugar esters, other surfactants, other detergents and pluronics, and mixtures thereof. Alternatively, stable multiphase systems could be employed to safely solubilize therapeutics for intrathecal delivery (e.g., liposomes, micro/nano emulsions, nanoparticles, dendrimers, micro/nano spheres).
Any suitable amount of solubility enhancing agent sufficient to solubilize the active agent of interest to the desired concentration may be used. In certain aspects, molar ratios of active agent to solubility-enhancing agent ranging from about 0.5:1 to about 1:10, particularly, about 1:1 to about 1:5, more particularly 1:1 to about 1:2, may be used to achieve adequate solubility of the active agent to the desired concentrations.
12 2. Stabilizing Excipients In addition to solubility, the active agent must be sufficiently stable within the composition to withstand hydrolytic and oxidative degradation in order to maintain biological activity during administration. Active agents generally possesses the therapeutic effects observed during conventional administration; the stability of the medicament in the composition prior to central administration is also of importance. To this end, in certain aspects, the compositions of the present invention may further include stabilizing excipients and buffers acceptable for use in the eye.
Considering that oxidation represents a common degradation pathway, in certain aspects, the compositions of the invention may be deoxygenated (e.g., by saturating with nitrogen gas) to minimize the formation of reactive oxygen species that would degrade the active agent during storage. Another method would be to ensure that formulations are stored in a container that does not allow passage of light, thereby minimizing photo-induced degradation.
In addition, in accordance with certain aspects of the invention, stabilizing excipients may optionally be used to, e.g., prevent or slow degradation by oxidation and/or hydrolysis of the active agents. For example, vitamin E, methionine, chelators and mannitol may be used to reduce oxidative degradation. Since the rates of many degradation reactions are pH-dependent, such formulations may include any suitable buffering agent known in the art (e.g., phosphate, acetate, glycine, citrate, imidazole, TRIS, MES, MOPS).
Stabilizing excipients useful in the context of the compositions described herein include any medicamently acceptable components which function to enhance the physical stability, and/or chemical stability of the active agent in the compositions of the invention. The medicament compositions described herein may include one or more stabilizing excipients, and each excipient may have one or more stabilizing functions.
In one aspect, the stabilizing excipient may function to stabilize the active agent against chemical degradation, e.g., oxidation, deamidation, deamination, or hydrolysis. In this regard, the stabilizing excipients may optionally be selected from antioxidants, such as ascorbic acid (vitamin C), vitamin E, tocopherol conjugates, tocopherol succinate, PEGylated tocopherol succinate, Tris salt of tocopherol succinate, Trolox, mannitol, sucrose, phytic acid, trimercaprol or glutathione.
The term "effective amount" refers to an amount of an active agent used to treat, ameliorate, prevent, or eliminate the identified ophthalmic condition (e.g., disease or disorder), or to exhibit a detectable therapeutic or preventative effect. The effect can be detected by, for example, chemical markers, antigen levels, or time to a measurable event, such as morbidity or
Considering that oxidation represents a common degradation pathway, in certain aspects, the compositions of the invention may be deoxygenated (e.g., by saturating with nitrogen gas) to minimize the formation of reactive oxygen species that would degrade the active agent during storage. Another method would be to ensure that formulations are stored in a container that does not allow passage of light, thereby minimizing photo-induced degradation.
In addition, in accordance with certain aspects of the invention, stabilizing excipients may optionally be used to, e.g., prevent or slow degradation by oxidation and/or hydrolysis of the active agents. For example, vitamin E, methionine, chelators and mannitol may be used to reduce oxidative degradation. Since the rates of many degradation reactions are pH-dependent, such formulations may include any suitable buffering agent known in the art (e.g., phosphate, acetate, glycine, citrate, imidazole, TRIS, MES, MOPS).
Stabilizing excipients useful in the context of the compositions described herein include any medicamently acceptable components which function to enhance the physical stability, and/or chemical stability of the active agent in the compositions of the invention. The medicament compositions described herein may include one or more stabilizing excipients, and each excipient may have one or more stabilizing functions.
In one aspect, the stabilizing excipient may function to stabilize the active agent against chemical degradation, e.g., oxidation, deamidation, deamination, or hydrolysis. In this regard, the stabilizing excipients may optionally be selected from antioxidants, such as ascorbic acid (vitamin C), vitamin E, tocopherol conjugates, tocopherol succinate, PEGylated tocopherol succinate, Tris salt of tocopherol succinate, Trolox, mannitol, sucrose, phytic acid, trimercaprol or glutathione.
The term "effective amount" refers to an amount of an active agent used to treat, ameliorate, prevent, or eliminate the identified ophthalmic condition (e.g., disease or disorder), or to exhibit a detectable therapeutic or preventative effect. The effect can be detected by, for example, chemical markers, antigen levels, or time to a measurable event, such as morbidity or
13 mortality. The precise effective amount for a subject will depend upon the subject's body weight, size, and health; the nature and extent of the condition; and the therapeutic or combination of therapeutics selected for administration. Effective amounts for a given situation can be determined by routine experimentation that is within the skill and judgment of the clinician. Any of the agents can be provided in an effective amount.
For any active agent, the effective amount can be estimated initially either in cell culture assays, e.g., in animal models, such as rat or mouse models. An animal model may also be used to determine the appropriate concentration range and route of administration.
Such information can then be used to determine useful doses and routes for administration in humans.
To assist in understanding the present invention, the following Example is included.
The experiments described herein should not, of course, be construed as specifically limiting the invention and such variations of the invention, now known or later developed, which would be within the purview of one skilled in the art are considered to fall within the scope of the invention as described herein and hereinafter claimed.
U.S. Application Attorney Docket Number 24591.003-US03, filed concurrently herewith, entitled "Drop-Generating Device", and U.S. Application Attorney Docket Number 24591.003-U502, filed concurrently herewith, entitled "Method and System for Performing Remote Treatment and Monitoring" are also each herein incorporated by reference in their entireties.
Example Table A describes quantification of average droplet size and the maximum number of doses of various medications from individual eyedropper containers. Each experiment is repeated in three trials to calculate a more accurate average droplet size. By taking the volume of individual bottles and dividing it by the average droplet size, the maximum number of doses per eyedropper is calculated.
Column A contains the retail name of medications. In column B, the concentration of active ingredient of medication is listed as a percentage where publically available. Column C
contains the name of preservative used in the medication, with column D
displaying the percentage of the preservative in the solution. Column E is the manufacturer of the medication and column F is its classification as over-the counter (OTC) or by prescription (Rx). Columns G, H and I represent values from individual trials. The average in Column J is calculated using the values of G, H and I. Every bottle has a unique volume to contain a set amount of medication, which is noted in column K. The value in column K is divided by the average in column J to determine the number of doses possible as noted in Column L.
For any active agent, the effective amount can be estimated initially either in cell culture assays, e.g., in animal models, such as rat or mouse models. An animal model may also be used to determine the appropriate concentration range and route of administration.
Such information can then be used to determine useful doses and routes for administration in humans.
To assist in understanding the present invention, the following Example is included.
The experiments described herein should not, of course, be construed as specifically limiting the invention and such variations of the invention, now known or later developed, which would be within the purview of one skilled in the art are considered to fall within the scope of the invention as described herein and hereinafter claimed.
U.S. Application Attorney Docket Number 24591.003-US03, filed concurrently herewith, entitled "Drop-Generating Device", and U.S. Application Attorney Docket Number 24591.003-U502, filed concurrently herewith, entitled "Method and System for Performing Remote Treatment and Monitoring" are also each herein incorporated by reference in their entireties.
Example Table A describes quantification of average droplet size and the maximum number of doses of various medications from individual eyedropper containers. Each experiment is repeated in three trials to calculate a more accurate average droplet size. By taking the volume of individual bottles and dividing it by the average droplet size, the maximum number of doses per eyedropper is calculated.
Column A contains the retail name of medications. In column B, the concentration of active ingredient of medication is listed as a percentage where publically available. Column C
contains the name of preservative used in the medication, with column D
displaying the percentage of the preservative in the solution. Column E is the manufacturer of the medication and column F is its classification as over-the counter (OTC) or by prescription (Rx). Columns G, H and I represent values from individual trials. The average in Column J is calculated using the values of G, H and I. Every bottle has a unique volume to contain a set amount of medication, which is noted in column K. The value in column K is divided by the average in column J to determine the number of doses possible as noted in Column L.
14 TABLE A
med in Preserv Bottle Name solution Preservative in Company RX/ Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (%) (ml) Blink tears Sodium Chlorate Advanced OTC 0.041 0.046 0.041 0.0427 15 352 Medical Optics thera tears (sodium 0.025 Sodium Perborate Advanced OTC 0.046 0.05 0.049 0.0483 30 621 carboxymethylcellulo Vision se) Research Naphcon A 0.3 Benzalkonium 0.01 Alcon OTC 0.038 0.04 0.04 0.0393 15 381 (Pheniramine Chloride Maleate) Opti-free express Polyquad Alcon OTC 0.036 0.038 0.038 0.037333 20 535.7 rewetting drops Opti-free Replenish Polyquad 0.001 Alcon OTC 0.026 0.027 0.029 0.0273 10 366 Systane Balance 0.6 Polyquad 0.001 Alcon OTC 0.039 0.035 0.035 0.0363 10 275 (propylene glycol) Systane Lubricant Polyquad Alcon OTC 0.038 0.044 0.05 0.0440 15 341 Eye drops Systane ultra Polyquad 0.001 Alcon OTC 0.047 0.047 0.049 0.0477 10 210 Tears Naturale II Polyquad 0.001 Alcon OTC 0.057 0.056 0.06 0.0577 15 260 Refresh optive 0.5 PURITE Allergan OTC 0.04 0.041 0.04 0.0403 15 372 (Carboxymethylcellu lose Sodium) Refresh Tears 0.5 PURITE Allergan OTC 0.054 0.055 0.059 0.0560 15 268 (Carboxymethylcellu lose Sodium) Adv. Eye Relief Dry Benzalkonium 0.01 Bausch & OTC 0.027 0.028 0.03 0.0283 15 529 Eye Chloride Lomb Adv. Eye relief 0.03 Benzalkonium 0.01 Bausch & OTC 0.032 0.031 0.032 0.0317 15 474 Redness Chloride Lomb (Naphazoline HC1) Alaway (ketotifen 0.035 Benzalkonium 0.01 Bausch & OTC 0.036 0.034 0.035 0.0350 10 286 fumarate) Chloride Lomb Muro128 Bausch & OTC 0.038 0.041 0.038 0.0390 15 385 Lomb Opcon-A Benzalkonium Bausch & OTC 0.028 0.031 0.032 0.0303 15 495 Chloride Lomb Renu Sorbic acid, 0.15 and Bausch & OTC 0.036 0.039 0.041 0.0387 15 388 Disodium edetate .1 Lomb
med in Preserv Bottle Name solution Preservative in Company RX/ Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (%) (ml) Blink tears Sodium Chlorate Advanced OTC 0.041 0.046 0.041 0.0427 15 352 Medical Optics thera tears (sodium 0.025 Sodium Perborate Advanced OTC 0.046 0.05 0.049 0.0483 30 621 carboxymethylcellulo Vision se) Research Naphcon A 0.3 Benzalkonium 0.01 Alcon OTC 0.038 0.04 0.04 0.0393 15 381 (Pheniramine Chloride Maleate) Opti-free express Polyquad Alcon OTC 0.036 0.038 0.038 0.037333 20 535.7 rewetting drops Opti-free Replenish Polyquad 0.001 Alcon OTC 0.026 0.027 0.029 0.0273 10 366 Systane Balance 0.6 Polyquad 0.001 Alcon OTC 0.039 0.035 0.035 0.0363 10 275 (propylene glycol) Systane Lubricant Polyquad Alcon OTC 0.038 0.044 0.05 0.0440 15 341 Eye drops Systane ultra Polyquad 0.001 Alcon OTC 0.047 0.047 0.049 0.0477 10 210 Tears Naturale II Polyquad 0.001 Alcon OTC 0.057 0.056 0.06 0.0577 15 260 Refresh optive 0.5 PURITE Allergan OTC 0.04 0.041 0.04 0.0403 15 372 (Carboxymethylcellu lose Sodium) Refresh Tears 0.5 PURITE Allergan OTC 0.054 0.055 0.059 0.0560 15 268 (Carboxymethylcellu lose Sodium) Adv. Eye Relief Dry Benzalkonium 0.01 Bausch & OTC 0.027 0.028 0.03 0.0283 15 529 Eye Chloride Lomb Adv. Eye relief 0.03 Benzalkonium 0.01 Bausch & OTC 0.032 0.031 0.032 0.0317 15 474 Redness Chloride Lomb (Naphazoline HC1) Alaway (ketotifen 0.035 Benzalkonium 0.01 Bausch & OTC 0.036 0.034 0.035 0.0350 10 286 fumarate) Chloride Lomb Muro128 Bausch & OTC 0.038 0.041 0.038 0.0390 15 385 Lomb Opcon-A Benzalkonium Bausch & OTC 0.028 0.031 0.032 0.0303 15 495 Chloride Lomb Renu Sorbic acid, 0.15 and Bausch & OTC 0.036 0.039 0.041 0.0387 15 388 Disodium edetate .1 Lomb
15 med in Preservin RX/
Bottle Name solution Preservative solution Company OTC Trial 1 Trial 2 Trial 3 Avg Size Doses (%) (%) (ml) Sensitive eyes Sorbic Acid and .1 and Bausch &
OTC 0.039 0.038 0.04 0.0390 30 Disodium edetate .025 Lomb Soothe xp polyhexamethyle Bausch & OTC 0.033 0.033 0.033 0.0330 ne biguanide Lomb Visine A.C. 0.05 Benzalkonium Johnson & OTC 0.036 0.036 0.038 0.0367 (Tetrahydrozoline Chloride Johnson HC1) Visine Advanced 0.05 Benzalkonium Johnson & OTC 0.038 0.043 0.041 0.0407 Relief Chloride Johnson (Tetrahydrozoline HC1) Visine Dry eye relief Benzalkonium 0.01 Johnson & OTC 0.031 0.03 0.027 0.0293 15 Chloride Johnson Visine L.R. Long 0.025 Benzalkonium Johnson & OTC 0.036 0.036 0.032 0.0347 Lasting Redness Chloride Johnson Relief (Oxymetazoline HC1) Visine Max Redness 0.05 Benzalkonium Johnson & OTC 0.04 0.042 0.042 0.0413 15 Relief Chloride Johnson (Tetrahydrozoline HC1) Visine original 0.05 Benzalkonium Johnson & OTC 0.034 0.034 0.034 0.0340 (Tetrahydrozoline Chloride Johnson HC1) Visine-A 0.3 Benzalkonium 0.01 Johnson & OTC 0.031 0.031 0.033 0.0317 (Pheniramine Chloride Johnson Maleate) Optimum WRW
Benzyl Alcohol, .1, .05, Lobob OTC 0.055 0.052 0.058 0.055 30 545.5 (fluorosilicone Sorbic Acid, .1 acrylate) Disodium edetate Clear eyes natural Benzalkonium MedTech OTC 0.026 0.03 0.024 0.0267 15 tears lubricant Chloride Products Clear eyes Redness 0.012 Benzalkonium MedTech OTC 0.024 0.02 0.021 0.0217 30 relief (naphazoline Chloride Products HC1) GenTeal GenAqua Novartis OTC 0.046 0.046 0.047 0.0463 15 324 (hydroxypropyl (Sodium methylcellulose) perborate) Hypo tears Benzalkonium 0.01 Novartis OTC 0.032 0.039 0.038 0.0363 Chloride
Bottle Name solution Preservative solution Company OTC Trial 1 Trial 2 Trial 3 Avg Size Doses (%) (%) (ml) Sensitive eyes Sorbic Acid and .1 and Bausch &
OTC 0.039 0.038 0.04 0.0390 30 Disodium edetate .025 Lomb Soothe xp polyhexamethyle Bausch & OTC 0.033 0.033 0.033 0.0330 ne biguanide Lomb Visine A.C. 0.05 Benzalkonium Johnson & OTC 0.036 0.036 0.038 0.0367 (Tetrahydrozoline Chloride Johnson HC1) Visine Advanced 0.05 Benzalkonium Johnson & OTC 0.038 0.043 0.041 0.0407 Relief Chloride Johnson (Tetrahydrozoline HC1) Visine Dry eye relief Benzalkonium 0.01 Johnson & OTC 0.031 0.03 0.027 0.0293 15 Chloride Johnson Visine L.R. Long 0.025 Benzalkonium Johnson & OTC 0.036 0.036 0.032 0.0347 Lasting Redness Chloride Johnson Relief (Oxymetazoline HC1) Visine Max Redness 0.05 Benzalkonium Johnson & OTC 0.04 0.042 0.042 0.0413 15 Relief Chloride Johnson (Tetrahydrozoline HC1) Visine original 0.05 Benzalkonium Johnson & OTC 0.034 0.034 0.034 0.0340 (Tetrahydrozoline Chloride Johnson HC1) Visine-A 0.3 Benzalkonium 0.01 Johnson & OTC 0.031 0.031 0.033 0.0317 (Pheniramine Chloride Johnson Maleate) Optimum WRW
Benzyl Alcohol, .1, .05, Lobob OTC 0.055 0.052 0.058 0.055 30 545.5 (fluorosilicone Sorbic Acid, .1 acrylate) Disodium edetate Clear eyes natural Benzalkonium MedTech OTC 0.026 0.03 0.024 0.0267 15 tears lubricant Chloride Products Clear eyes Redness 0.012 Benzalkonium MedTech OTC 0.024 0.02 0.021 0.0217 30 relief (naphazoline Chloride Products HC1) GenTeal GenAqua Novartis OTC 0.046 0.046 0.047 0.0463 15 324 (hydroxypropyl (Sodium methylcellulose) perborate) Hypo tears Benzalkonium 0.01 Novartis OTC 0.032 0.039 0.038 0.0363 Chloride
16 Preserv med in Bottle in RX/
Name solution Preservative Company Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (ml) (%) Zaditor (ketotifen 0.025 Benzalkonium 0.01 Novartis OTC 0.033 0.032 0.034 0.0330 5 152 fumarate) Chloride Rohto arctic 0.05 Rohto OTC 0.035 0.03 0.034 0.0330 13 394 (Tetrahydrozoline HC1) Rohto Cool 0.012 Benzalkonium Rohto OTC 0.037 0.033 0.03 0.0333 13 390 (naphazoline HC1) Chloride Rohto Hydra 0.3 Rohto OTC 0.041 0.034 0.03 0.0350 13 371 (hypromellose) Rohto ice (Zinc 0.25 Rohto OTC 0.035 0.03 0.038 0.0343 13 379 Sulfate) Similasan allergy eye Silver sulphate Similasan OTC 0.044 0.044 0.046 0.0447 10 224 relief Similasan pink eye Silver sulphate Similasan OTC 0.048 0.045 0.048 0.0470 10 213 relief Walgreens artificial Benzalkonium 0.01 Walgreens OTC 0.028 0.03 0.032 0.0300 30 1000 tears Chloride Walgreens sterile None 0 Walgreens OTC 0.031 0.033 0.036 0.0333 32 artificial tears (ampules) AK-Dilate 2.5 Benzalkonium 0.01 Akorn Rx 0.023 0.029 0.029 0.0270 15 556 Phenylephrine Chloride Hydrochloride Azopt (brinzolamide) 1 Benzalkonium 0.01 Alcon Rx 0.039 0.039 0.039 0.0390 10 256 Chloride Nevanac (nepafenac) 0.1 Benzalkonium 0.005 Alcon Rx 0.04 0.039 0.043 0.0407 3 74 Chloride Pataday (olopatadine 0.2 Benzalkonium 0.01 Alcon Rx 0.028 0.029 0.027 0.0280 2.5 89 hydrochloride) Chloride Travatan 0.004 Sofzia Alcon Rx 0.03 0.034 0.034 0.0327 5 153 Z(travoprost) vigamox 0.5 None 0 Alcon Rx 0.039 0.045 0.046 0.0433 3 69 (moxifloxacin hydrochloride) Ketorolac 0.4 Benzalkonium 0.006 Alcon-Falcon Rx 0.025 0.026 0.024 0.0250 5 200 Tromethamine Chloride Prednisolone Acetate 1 Benzalkonium 0.01 Alcon-Falcon Rx 0.03 0.033 0.037 0.0333 5 150 Ophthalmic Chloride suspension Proparacaine 0.5 Benzalkonium 0.01 Alcon-Falcon Rx 0.036 0.04 0.042 0.0393 15 381
Name solution Preservative Company Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (ml) (%) Zaditor (ketotifen 0.025 Benzalkonium 0.01 Novartis OTC 0.033 0.032 0.034 0.0330 5 152 fumarate) Chloride Rohto arctic 0.05 Rohto OTC 0.035 0.03 0.034 0.0330 13 394 (Tetrahydrozoline HC1) Rohto Cool 0.012 Benzalkonium Rohto OTC 0.037 0.033 0.03 0.0333 13 390 (naphazoline HC1) Chloride Rohto Hydra 0.3 Rohto OTC 0.041 0.034 0.03 0.0350 13 371 (hypromellose) Rohto ice (Zinc 0.25 Rohto OTC 0.035 0.03 0.038 0.0343 13 379 Sulfate) Similasan allergy eye Silver sulphate Similasan OTC 0.044 0.044 0.046 0.0447 10 224 relief Similasan pink eye Silver sulphate Similasan OTC 0.048 0.045 0.048 0.0470 10 213 relief Walgreens artificial Benzalkonium 0.01 Walgreens OTC 0.028 0.03 0.032 0.0300 30 1000 tears Chloride Walgreens sterile None 0 Walgreens OTC 0.031 0.033 0.036 0.0333 32 artificial tears (ampules) AK-Dilate 2.5 Benzalkonium 0.01 Akorn Rx 0.023 0.029 0.029 0.0270 15 556 Phenylephrine Chloride Hydrochloride Azopt (brinzolamide) 1 Benzalkonium 0.01 Alcon Rx 0.039 0.039 0.039 0.0390 10 256 Chloride Nevanac (nepafenac) 0.1 Benzalkonium 0.005 Alcon Rx 0.04 0.039 0.043 0.0407 3 74 Chloride Pataday (olopatadine 0.2 Benzalkonium 0.01 Alcon Rx 0.028 0.029 0.027 0.0280 2.5 89 hydrochloride) Chloride Travatan 0.004 Sofzia Alcon Rx 0.03 0.034 0.034 0.0327 5 153 Z(travoprost) vigamox 0.5 None 0 Alcon Rx 0.039 0.045 0.046 0.0433 3 69 (moxifloxacin hydrochloride) Ketorolac 0.4 Benzalkonium 0.006 Alcon-Falcon Rx 0.025 0.026 0.024 0.0250 5 200 Tromethamine Chloride Prednisolone Acetate 1 Benzalkonium 0.01 Alcon-Falcon Rx 0.03 0.033 0.037 0.0333 5 150 Ophthalmic Chloride suspension Proparacaine 0.5 Benzalkonium 0.01 Alcon-Falcon Rx 0.036 0.04 0.042 0.0393 15 381
17 Preserv med in Bottle in RX/
Name solution Preservative Company Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (ml) (%) Hydrochloride Chloride Ophthalmic solution Tobramycin and 0.4 Benzalkonium 0.01 Alcon-Falcon Rx 0.032 0.033 0.029 0.0313 5 160 Dexamethasone Chloride Tropicamide 1 Benzalkonium 0.01 Alcon-Falcon Rx 0.033 0.028 0.034 0.0317 15 474 Chloride Alphagan P 0.1 PURITE 0.005 Allergan Rx 0.041 0.042 0.05 0.0443 5 113 (brimonidine tartrate) Lumigan 0.03 Benzalkonium 0.005 Allergan Rx 0.025 0.021 0.022 0.0227 5 221 (bimatoprost) Chloride Restasis 0.05 None (Sterile) 0 Allergan Rx 0.025 0.023 0.025 0.0243 30 (cyclosporine) (ampules) Zymar (gatifloxacin) 0.3 Benzalkonium 0.005 Allergan Rx 0.029 0.031 0.031 0.0303 5 165 Chloride Zymaxid 0.5 Benzalkonium 0.005 Allergan Rx 0.033 0.035 0.032 0.0333 2.5 75 (gatifloxacin) Chloride Alrex (loteprednol 0.2 Benzalkonium 0.01 Bausch & Rx 0.032 0.034 0.033 0.0330 5 152 etabonate) Chloride Lomb Bepreve (bepotastine 1.5 Benzalkonium 0.005 Bausch & Rx 0.031 0.033 0.03 0.0313 5 160 besilate) Chloride Lomb Besivance 0.6 Benzalkonium 0.01 Bausch & Rx 0.036 0.041 0.04 0.0390 5 128 (besifloxacin) Chloride Lomb Lotemax (loteprednol 0.5 Benzalkonium 0.01 Bausch & Rx 0.029 0.031 0.031 0.0303 5 165 etabonate) Chloride Lomb Dorzolamide HC1 Benzalkonium 0.0075 Hi-tech Rx 0.051 0.048 0.053 0.0507 10 197 Timolol Maleate Chloride AzaSite 1 Benzalkonium 0.003 Inspire Rx 0.046 0.045 0.051 0.0473 2.5 53 (azithromycin) Chloride Bromday 0.09 Benzalkonium Ista Rx 0.046 0.04 0.038 0.0413 1.7 41 (bromfenac) Chloride Levofloxacin 0.5 Benzalkonium 0.005 Pack Rx 0.028 0.027 0.025 0.0267 5 188 Chloride Xalatan (latanoprost) 0.005 Benzalkonium 0.02 Pfizer Rx 0.022 0.023 0.026 0.0237 2.5 106 Chloride Istalol 0.5 Benzalkonium 0.005 Senju Rx 0.026 0.031 0.031 0.0293 5 170 Chloride Durezol 0.05 Sorbic Acid 0.1 Sirion Rx 0.04 0.039 0.034 0.0377 5 133 (difiuprednate) Therapeutics
Name solution Preservative Company Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (ml) (%) Hydrochloride Chloride Ophthalmic solution Tobramycin and 0.4 Benzalkonium 0.01 Alcon-Falcon Rx 0.032 0.033 0.029 0.0313 5 160 Dexamethasone Chloride Tropicamide 1 Benzalkonium 0.01 Alcon-Falcon Rx 0.033 0.028 0.034 0.0317 15 474 Chloride Alphagan P 0.1 PURITE 0.005 Allergan Rx 0.041 0.042 0.05 0.0443 5 113 (brimonidine tartrate) Lumigan 0.03 Benzalkonium 0.005 Allergan Rx 0.025 0.021 0.022 0.0227 5 221 (bimatoprost) Chloride Restasis 0.05 None (Sterile) 0 Allergan Rx 0.025 0.023 0.025 0.0243 30 (cyclosporine) (ampules) Zymar (gatifloxacin) 0.3 Benzalkonium 0.005 Allergan Rx 0.029 0.031 0.031 0.0303 5 165 Chloride Zymaxid 0.5 Benzalkonium 0.005 Allergan Rx 0.033 0.035 0.032 0.0333 2.5 75 (gatifloxacin) Chloride Alrex (loteprednol 0.2 Benzalkonium 0.01 Bausch & Rx 0.032 0.034 0.033 0.0330 5 152 etabonate) Chloride Lomb Bepreve (bepotastine 1.5 Benzalkonium 0.005 Bausch & Rx 0.031 0.033 0.03 0.0313 5 160 besilate) Chloride Lomb Besivance 0.6 Benzalkonium 0.01 Bausch & Rx 0.036 0.041 0.04 0.0390 5 128 (besifloxacin) Chloride Lomb Lotemax (loteprednol 0.5 Benzalkonium 0.01 Bausch & Rx 0.029 0.031 0.031 0.0303 5 165 etabonate) Chloride Lomb Dorzolamide HC1 Benzalkonium 0.0075 Hi-tech Rx 0.051 0.048 0.053 0.0507 10 197 Timolol Maleate Chloride AzaSite 1 Benzalkonium 0.003 Inspire Rx 0.046 0.045 0.051 0.0473 2.5 53 (azithromycin) Chloride Bromday 0.09 Benzalkonium Ista Rx 0.046 0.04 0.038 0.0413 1.7 41 (bromfenac) Chloride Levofloxacin 0.5 Benzalkonium 0.005 Pack Rx 0.028 0.027 0.025 0.0267 5 188 Chloride Xalatan (latanoprost) 0.005 Benzalkonium 0.02 Pfizer Rx 0.022 0.023 0.026 0.0237 2.5 106 Chloride Istalol 0.5 Benzalkonium 0.005 Senju Rx 0.026 0.031 0.031 0.0293 5 170 Chloride Durezol 0.05 Sorbic Acid 0.1 Sirion Rx 0.04 0.039 0.034 0.0377 5 133 (difiuprednate) Therapeutics
18 Preserv med in Bottle in RX/
Name solution Preservative Company Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (ml) (%) Dorzolamide HC1 2 Benzalkonium 0.0075 Teva Rx 0.036 0.04 0.04 0.0387 10 259 Chloride BAK free 0.035 0.033 0.034 0.0340 Latanoprost
Name solution Preservative Company Trial 1 Trial 2 Trial 3 Avg Size Doses solution OTC
(%) (ml) (%) Dorzolamide HC1 2 Benzalkonium 0.0075 Teva Rx 0.036 0.04 0.04 0.0387 10 259 Chloride BAK free 0.035 0.033 0.034 0.0340 Latanoprost
19
Claims (52)
1. A method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising:
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns and an average initial ejecting velocity between 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns and an average initial ejecting velocity between 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
2. The method according to claim 1, wherein said medicament is delivered in an aqueous droplet solution.
3. The method according to claim 2, wherein said medicament is delivered in an oil/water emulsion droplet.
4. The method according to claim 3, wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
5. The method according to claim 1, wherein said medicament is a glaucoma medicament.
6. The method according to claim 1, wherein said medicament is an antibiotic.
7. The method according to claim 1, wherein said average droplets ejecting size is in the range of about 30 microns to about 60 microns.
8. The method according to claim 1, wherein said average initial droplet ejecting velocity is between about 1 m/s to about 4 m/s.
9. The method according to claim 1, wherein said medicament is selected from the group consisting of ranibizumab antibody FAB ( including Lucentis), VEGF Trap fusion molecule (including VEGF Trap-Eye), microplasmin enzyme (including Ocriplasmin), macugen pegylated polypeptide (including Pegaptanib), and bevacizumab (including Avastin).20
10. The method according to claim 1, wherein said medicament comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HCl, pheniramine maleate, ketotifen fumarate, oxymetazoline HCl, naphazoline HCl, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost.
11. The method according to claim 1, wherein said medicament comprises a medicament selected from the group consisting of fluorosilicone acrylate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HCl, timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, carboxymethylcellulose sodium, propylene glycol, hypromellose, zinc sulfate, dorzolamide HCl dorzolamide HCl, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine.
12. The method according to claim 1, wherein said medicament is selected from the timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK
free latanoprost.
group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl
free latanoprost.
group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl
13. A method of delivering a medicament solution on the eye to a subject in need thereof by controlling average droplet size and deposit parameters of said medicament solution comprising:
(a) determining desired dosage of said medicament solution for said subject in need thereof; and (b) providing said desired dosage in a single application by determining said average droplet size and deposit parameters of said medicament solution on the eye.
(a) determining desired dosage of said medicament solution for said subject in need thereof; and (b) providing said desired dosage in a single application by determining said average droplet size and deposit parameters of said medicament solution on the eye.
14. The method according to claim 13, wherein said medicament is delivered in an aqueous droplet solution.
15. The method according to claim 14, wherein said medicament is delivered in an oil/water emulsion droplet.
16. The method according to claim 15, wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
17. The method according to claim 13, wherein said medicament is a glaucoma medicament.
18. The method according to claim 13, wherein said medicament is an antibiotic.
19. The method according to claim 13, wherein said average droplet ejecting size is in the range of about 30 microns to about 60 microns.
20. The method according to claim 13, wherein said average droplet initial ejecting velocity is between about 0.5 m/s to about 20 m/s.
21. The method according to claim 13, wherein said medicament is selected from the group consisting of ranibizumab antibody FAB ( including Lucentis), VEGF Trap fusion molecule (including VEGF Trap-Eye), microplasmin enzyme (including Ocriplasmin), macugen pegylated polypeptide (including Pegaptanib), and bevacizumab (including Avastin).
22. The method according to claim 13, wherein said medicament comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HCl, pheniramine maleate, ketotifen fumarate, oxymetazoline HCl, naphazoline HCl, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost.
23. The method according to claim 13, wherein said medicament comprises a medicament selected from the group consisting of fluorosilicone acrylate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HCl, carboxymethylcellulose sodium, propylene glycol, hypromellose, zinc sulfate, dorzolamide HCl timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, dorzolamide HCl, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine.
24.
The method according to claim 13, wherein said medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK
free latanoprost.
The method according to claim 13, wherein said medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK
free latanoprost.
25.
A method for providing a solution to the eye comprising:
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between about 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
A method for providing a solution to the eye comprising:
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between about 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
26.
The method of claim 25, wherein said solution is an isotonic saline solution.
The method of claim 25, wherein said solution is an isotonic saline solution.
27.
The method according to claim 25, wherein said solution comprises a medicament and said medicament is delivered in an aqueous droplet solution.
The method according to claim 25, wherein said solution comprises a medicament and said medicament is delivered in an aqueous droplet solution.
28.
The method according to claim 25, wherein said solution comprises a medicament and said medicament is delivered in an oil/water emulsion droplet.
The method according to claim 25, wherein said solution comprises a medicament and said medicament is delivered in an oil/water emulsion droplet.
29.
The method according to claim 28, wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
The method according to claim 28, wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
30.
The method according to claim 27, wherein said medicament is a glaucoma medicament.
The method according to claim 27, wherein said medicament is a glaucoma medicament.
31.
The method according to claim 27, wherein said medicament is an antibiotic.
The method according to claim 27, wherein said medicament is an antibiotic.
32.
The method according to claim 25, wherein said average droplet ejecting size is in the range of about 30 microns to about 60 microns.
The method according to claim 25, wherein said average droplet ejecting size is in the range of about 30 microns to about 60 microns.
33.
The method according to claim 25, wherein said average droplet initial ejecting velocity is between about 1 m/s to about 4 m/s.
The method according to claim 25, wherein said average droplet initial ejecting velocity is between about 1 m/s to about 4 m/s.
34.
The method according to claim 27, said medicament is selected from the group consisting of ranibizumab antibody FAB ( including Lucentis), VEGF Trap fusion molecule (including VEGF Trap-Eye), microplasmin enzyme (including Ocriplasmin), macugen pegylated polypeptide (including Pegaptanib), and bevacizumab (including Avastin).
The method according to claim 27, said medicament is selected from the group consisting of ranibizumab antibody FAB ( including Lucentis), VEGF Trap fusion molecule (including VEGF Trap-Eye), microplasmin enzyme (including Ocriplasmin), macugen pegylated polypeptide (including Pegaptanib), and bevacizumab (including Avastin).
35.
The method according to claim 27, wherein said medicament comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HCl, pheniramine maleate, ketotifen fumarate, oxymetazoline HCl, naphazoline HCl, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost.
The method according to claim 27, wherein said medicament comprises a medicament selected from the group consisting of carboxymethylcellulose sodium, tetrahydrozoline HCl, pheniramine maleate, ketotifen fumarate, oxymetazoline HCl, naphazoline HCl, pheniramine maleate, moxifloxacin hydrochloride, bromfenac, proparacaine hydrochloride, difluprednate, gatifloxacin, travoprost, bepotastine besilate, gatifloxacin, loteprednol etabonate, timolol ophthalmic, olopatadine hydrochloride, phenylephrine hydrochloride, levofloxacin, ketorolac tromethamine, letanoprost, bimatoprost and BAK free latanoprost.
36.
The method according to claim 27, wherein said medicament comprises a medicament selected from the group consisting of fluorosilicone acrylate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HCl, carboxymethylcellulose sodium, propylene glycol, hypromellose, zinc sulfate, dorzolamide HCl timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, dorzolamide HCl, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine.
The method according to claim 27, wherein said medicament comprises a medicament selected from the group consisting of fluorosilicone acrylate, sodium carboxymethylcellulose, hydroxypropyl methylcellulose, tetrahydrozoline HCl, carboxymethylcellulose sodium, propylene glycol, hypromellose, zinc sulfate, dorzolamide HCl timolol maleate, azithromycin, brimonidine tartrate, nepafenac, brinzolamide, besifloxacin, dorzolamide HCl, prenisone acetate, loteprednol etabonate, tobramycin/dexamethasone, and cyclosporine.
37.
The method according to claim 27, wherein said medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK
free latanoprost.
The method according to claim 27, wherein said medicament is selected from the group consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK
free latanoprost.
38. A method of treating glaucoma in a subject in need there of comprising:
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 micron in diameter and an average initial ejecting velocity of between about 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 micron in diameter and an average initial ejecting velocity of between about 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
39. The method according to claim 38, wherein said medicament is delivered in an aqueous droplet solution.
40. The method according to claim 39, wherein said medicament is delivered in an oil/water emulsion droplet.
41. The method according to claim 40, wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
42. The method according to claim 38, wherein said average droplets ejecting size is in the range of about 30 microns to about 60 microns.
43. The method according to claim 38, wherein said average droplet initial ejecting velocity is between about 1 m/s to about 4 m/s.
44. The method according to claim 38, said medicament is selected from the group maleate, brimonidine tartrate, brinzolamide, dorzolamide HCl, and BAK free latanoprost.
consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol
consisting of travoprost, timolol ophthalmic, latanoprost, bimatoprost, dorzolamide HCl timolol
45. A method of treating an infection in a subject in need thereof, comprising:
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between about 1 m/s and about 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between about 1 m/s and about 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye.
46. The method according to claim 45, wherein said medicament is delivered in an aqueous droplet solution.
47. The method according to claim 45, wherein said medicament is delivered in an oil/water emulsion droplet.
48. The method according to claim 47, wherein said oil in said oil/water emulsion droplet is a glycerin, a castor oil, or a polysorbate 80 mixture.
49. The method according to claim 46, wherein said average droplets ejecting size is in the range of about 30 microns to about 60 microns.
50. The method according to claim 46, wherein said average droplet initial ejecting velocity is between about 1 m/s to about 4 m/s.
51. The method according to claim 46, wherein said medicament comprises a medicament selected from the group consisting of tobramycin and gentamycin.
52. A method of providing a reduced dosage form of a medicament to an eye comprising:
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye, and wherein said droplets provide a total volume of less than 30 µI to said eye.
(a) providing droplets containing said medicament, wherein said droplets have an average droplet size of at least about 15 microns in diameter and an average initial ejecting velocity of between 1 m/s and 5 m/s; and (b) delivering said medicament to said eye, wherein between about 80% to about 100% of the ejected mass of said droplets are deposited on the eye, and wherein said droplets provide a total volume of less than 30 µI to said eye.
Applications Claiming Priority (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40086410P | 2010-07-15 | 2010-07-15 | |
US61/400,864 | 2010-07-15 | ||
US40191810P | 2010-08-20 | 2010-08-20 | |
US40184910P | 2010-08-20 | 2010-08-20 | |
US40184810P | 2010-08-20 | 2010-08-20 | |
US40185010P | 2010-08-20 | 2010-08-20 | |
US40192010P | 2010-08-20 | 2010-08-20 | |
US61/401,849 | 2010-08-20 | ||
US61/401,848 | 2010-08-20 | ||
US61/401,920 | 2010-08-20 | ||
US61/401,918 | 2010-08-20 | ||
US61/401,850 | 2010-08-20 | ||
US201161462576P | 2011-02-04 | 2011-02-04 | |
US61/462,576 | 2011-02-04 | ||
US201161462791P | 2011-02-05 | 2011-02-05 | |
US61/462,791 | 2011-02-05 | ||
US201161463280P | 2011-02-15 | 2011-02-15 | |
US61/463,280 | 2011-02-15 | ||
US201161516496P | 2011-04-04 | 2011-04-04 | |
US201161516495P | 2011-04-04 | 2011-04-04 | |
US201161516462P | 2011-04-04 | 2011-04-04 | |
US61/516,496 | 2011-04-04 | ||
US61/516,462 | 2011-04-04 | ||
US61/516,495 | 2011-04-04 | ||
US201161516694P | 2011-04-06 | 2011-04-06 | |
US61/516,694 | 2011-04-06 | ||
PCT/US2011/044278 WO2012009696A2 (en) | 2010-07-15 | 2011-07-15 | Ophthalmic drug delivery |
Publications (2)
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2011
- 2011-07-15 EP EP11738112.9A patent/EP2485691B1/en active Active
- 2011-07-15 JP JP2013519863A patent/JP2013531044A/en not_active Withdrawn
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CN103124541B (en) | 2015-09-30 |
JP6408504B2 (en) | 2018-10-17 |
US20170344714A1 (en) | 2017-11-30 |
CN103124541A (en) | 2013-05-29 |
EA201390120A3 (en) | 2013-09-30 |
ES2787254T3 (en) | 2020-10-15 |
JP2013531044A (en) | 2013-08-01 |
WO2012009696A2 (en) | 2012-01-19 |
JP2016154868A (en) | 2016-09-01 |
US10073949B2 (en) | 2018-09-11 |
CA2805425C (en) | 2019-07-23 |
US20150328151A1 (en) | 2015-11-19 |
KR20130051476A (en) | 2013-05-20 |
EP2485691B1 (en) | 2020-03-18 |
AU2011278924B2 (en) | 2015-06-18 |
MX2013000604A (en) | 2013-07-05 |
EA201390120A2 (en) | 2013-05-30 |
EP2485691A1 (en) | 2012-08-15 |
ZA201301155B (en) | 2014-04-30 |
AU2011278924A1 (en) | 2013-02-21 |
KR20170129298A (en) | 2017-11-24 |
KR20150031340A (en) | 2015-03-23 |
US20120070467A1 (en) | 2012-03-22 |
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