CA970692A - METHODS OF INHIBITING THE ACTIVITY OF TESTOSTERONE 5.alpha.-REDUCTASE - Google Patents
METHODS OF INHIBITING THE ACTIVITY OF TESTOSTERONE 5.alpha.-REDUCTASEInfo
- Publication number
- CA970692A CA970692A CA156,016A CA156016A CA970692A CA 970692 A CA970692 A CA 970692A CA 156016 A CA156016 A CA 156016A CA 970692 A CA970692 A CA 970692A
- Authority
- CA
- Canada
- Prior art keywords
- testosterone
- reductase
- inhibiting
- alpha
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US389741A US3917829A (en) | 1971-11-08 | 1973-08-20 | Novel methods of inhibiting the activity of testosterone 5{60 -reductase |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20159271A | 1971-11-08 | 1971-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA970692A true CA970692A (en) | 1975-07-08 |
Family
ID=22746454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA156,016A Expired CA970692A (en) | 1971-11-08 | 1972-11-08 | METHODS OF INHIBITING THE ACTIVITY OF TESTOSTERONE 5.alpha.-REDUCTASE |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA970692A (en) |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4220775A (en) * | 1979-03-15 | 1980-09-02 | Merck & Co., Inc. | Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors |
US4377584A (en) | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4760071A (en) * | 1984-02-27 | 1988-07-26 | Merck & Co., Inc. | 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors |
US4859681A (en) * | 1984-02-27 | 1989-08-22 | Merck & Co., Inc. | 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors |
US5049562A (en) * | 1984-02-27 | 1991-09-17 | Merck & Co., Inc. | 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
US5075450A (en) * | 1990-06-28 | 1991-12-24 | Merck & Co., Inc. | Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5120742A (en) * | 1984-02-27 | 1992-06-09 | Merck & Co., Inc. | 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
US5151429A (en) * | 1984-02-27 | 1992-09-29 | Merck & Co., Inc. | 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5155107A (en) * | 1990-02-09 | 1992-10-13 | Farmitalia Carlo Erba | 17β-substituted-4-aza-5α-androstan-3-one derivatives and process for their preparation |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
US5494914A (en) * | 1992-05-21 | 1996-02-27 | Endorecherche | Inhibitors for testosterone 5α-reductase activity |
US5527807A (en) * | 1992-05-20 | 1996-06-18 | Merck & Co., Inc. | 7β-substituted-4-aza-5α-cholestan-3-ones as 5α reductase inhibitors useful in the prevention and treatment of hyperandrogenetic disorders |
US5536727A (en) * | 1992-05-20 | 1996-07-16 | Merck & Co., Inc. | 17-Ethers and thioethers of 4-aza-steroids |
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US5610162A (en) * | 1992-05-20 | 1997-03-11 | Merck & Co., Inc. | Ester derivatives of 4-aza-steroids |
US5620986A (en) * | 1992-05-20 | 1997-04-15 | Merck & Co., Inc. | 17 urea, thiourea, thiocarbamyl and carbamyl4-azasteroid 5-reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders |
US5621104A (en) * | 1993-03-24 | 1997-04-15 | Merck & Co., Inc. | Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors |
US5639741A (en) * | 1992-05-20 | 1997-06-17 | Merck & Co., Inc. | 17-amino substituted 4-azasteroid 5α-reductase inhibitors |
US5693809A (en) * | 1992-05-20 | 1997-12-02 | Merck & Co., Inc. | Substituted 4-aza-5α-androstan-ones as 5α-reductase inhibitors |
-
1972
- 1972-11-08 CA CA156,016A patent/CA970692A/en not_active Expired
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4377584A (en) | 1978-04-13 | 1983-03-22 | Merck & Co., Inc. | 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors |
US4220775A (en) * | 1979-03-15 | 1980-09-02 | Merck & Co., Inc. | Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors |
US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
US4859681A (en) * | 1984-02-27 | 1989-08-22 | Merck & Co., Inc. | 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors |
US5049562A (en) * | 1984-02-27 | 1991-09-17 | Merck & Co., Inc. | 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors |
US4760071A (en) * | 1984-02-27 | 1988-07-26 | Merck & Co., Inc. | 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors |
US5120742A (en) * | 1984-02-27 | 1992-06-09 | Merck & Co., Inc. | 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors |
US5138063A (en) * | 1984-02-27 | 1992-08-11 | Merck & Co., Inc. | 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones |
US5151429A (en) * | 1984-02-27 | 1992-09-29 | Merck & Co., Inc. | 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors |
US5155107A (en) * | 1990-02-09 | 1992-10-13 | Farmitalia Carlo Erba | 17β-substituted-4-aza-5α-androstan-3-one derivatives and process for their preparation |
US5061802A (en) * | 1990-06-20 | 1991-10-29 | Merck & Co. Inc. | 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents |
US5162332A (en) * | 1990-06-20 | 1992-11-10 | Merck & Co., Inc. | Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors |
US5098908A (en) * | 1990-06-20 | 1992-03-24 | Merck & Co., Inc. | 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors |
US5151430A (en) * | 1990-06-20 | 1992-09-29 | Merck & Co., Inc. | Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents |
US5091380A (en) * | 1990-06-28 | 1992-02-25 | Merck & Co., Inc. | N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors |
US5075450A (en) * | 1990-06-28 | 1991-12-24 | Merck & Co., Inc. | Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes |
US5620986A (en) * | 1992-05-20 | 1997-04-15 | Merck & Co., Inc. | 17 urea, thiourea, thiocarbamyl and carbamyl4-azasteroid 5-reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders |
US5527807A (en) * | 1992-05-20 | 1996-06-18 | Merck & Co., Inc. | 7β-substituted-4-aza-5α-cholestan-3-ones as 5α reductase inhibitors useful in the prevention and treatment of hyperandrogenetic disorders |
US5536727A (en) * | 1992-05-20 | 1996-07-16 | Merck & Co., Inc. | 17-Ethers and thioethers of 4-aza-steroids |
US5610162A (en) * | 1992-05-20 | 1997-03-11 | Merck & Co., Inc. | Ester derivatives of 4-aza-steroids |
US5237064A (en) * | 1992-05-20 | 1993-08-17 | Merck & Co., Inc. | Process for producing 7β-substituted-aza-5αandrostan-3-ones |
US5639741A (en) * | 1992-05-20 | 1997-06-17 | Merck & Co., Inc. | 17-amino substituted 4-azasteroid 5α-reductase inhibitors |
US5693809A (en) * | 1992-05-20 | 1997-12-02 | Merck & Co., Inc. | Substituted 4-aza-5α-androstan-ones as 5α-reductase inhibitors |
US5494914A (en) * | 1992-05-21 | 1996-02-27 | Endorecherche | Inhibitors for testosterone 5α-reductase activity |
US5324734A (en) * | 1992-09-15 | 1994-06-28 | Merck & Co., Inc. | Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione |
US5278159A (en) * | 1992-10-06 | 1994-01-11 | Merck & Co., Inc. | Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors |
US5359071A (en) * | 1993-03-12 | 1994-10-25 | Merck & Co., Inc. | 15-substituted 4-azasteroids |
US5621104A (en) * | 1993-03-24 | 1997-04-15 | Merck & Co., Inc. | Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors |
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