CN100434126C - Implanted type programmable nervus stimulator - Google Patents
Implanted type programmable nervus stimulator Download PDFInfo
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- CN100434126C CN100434126C CNB2006100256583A CN200610025658A CN100434126C CN 100434126 C CN100434126 C CN 100434126C CN B2006100256583 A CNB2006100256583 A CN B2006100256583A CN 200610025658 A CN200610025658 A CN 200610025658A CN 100434126 C CN100434126 C CN 100434126C
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Abstract
The present invention relates to an implanted type programmable nerve stimulator which belongs to the technical field of medical appliances and comprises a communication part, a processing control part and an electrode driving part, wherein the communication part is connected with an exosomatic control part in a wireless radio-frequency way, and the back side of the communication part is connected with the processing control part; the back side of the processing control part is connected with the electrode driving part to drive an electrode array, the communication part is used for processing energy and information introduced in the wireless radio-frequency way, and the processing control part uses FPGA to decode, allocate, transmit and control the introduced information and control an electrode driving circuit and a power supply; the electrode driving part uses an analogous circuit to generate micro current or voltage, multi-stage continuous amplification is carried out to satisfy conditions required by different stimulation, and simultaneously, the function of extinguishing electric charges in an accumulating way is realized. The present invention is used for generating artificial auditory sensation and visual sense, relieving the symptoms of parkinsonism and depression and relieving patients' painful feeling, and has wide range of application.
Description
Technical field
The present invention relates to a kind of instrument of medical equipment technical field, specifically, what relate to is a kind of implanted type programmable nervus stimulator.
Background technology
With artificial cochlea and vision prosthesis is that the nerve prosthesis of representative mainly comprises: external information collection component divides and signal processing, and nerve stimulator and electrode part in the body transmit by wireless radiofrequency therebetween and carry out signal and energy delivery.At first, signal collection is partly gathered sound or image information, this information is passed to signal processing, handle, be encoded into the signal of telecommunication, be sent to body by wireless transmission method and be implanted into parts, produce electric pulse stimulation acoustic nerve or optic nerve (retina or visual cortex) to produce audition or vision.Nerve prosthesis can help the people who loses audition successfully to hear sound, makes the blind person see the world again.Nerve stimulator is one of core ingredient in the nerve prosthesis, not only can be used for carrying out effectively functional rehabilitation, symptom that can also the alleviating neuropathic disease, as: parkinson disease (PD), intractable depression and intractable pain etc.Along with developing rapidly of horseley-Clarke technique and nerve stimulation device, nerve stimulation has become the operation method that functional neurosurgery is used for treating parkinson disease, intractable depression, intractable pain and other dyskinetic a kind of novel Wicresofts of special property sent out.
Find that through literature search domestic patent CN1593683A has write down a kind of Parkinsonian chargeable brain depth stimulator that is used for the treatment of to prior art.It constitutes by being positioned at outer energy converter of human body and external control monitor and the subcutaneous stimulation pulse generator of implant into body.Wherein the subcutaneous stimulation pulse generator of implant into body by inner microcontroller and the boost pulse output module that is connected with internal microprocessor, positioning of electrode measurement module, internal wireless radio-frequency communication module, switch control module, module switch, power module constitutes, described module is switched and is connected with electrode.This stimulator has its specificity, does not have extensive applicability.
Another U.S. Pat 6415184B1 has put down in writing a kind of nerve stimulator of spherical implantable, and it realizes all kinds of nervous system diseasies of treatment for spherical implanted semiconductor system be used for the exciting nerve tissue of system.This globular implanted semiconductor is by a forward and a negative sense electrode pair and receive the receptor that transmits electric stimulation pulse by wireless transmission method and form.Produce electric impulse signal by external electric pulse generation system, the wireless receptor that is sent in the intravital spheric semiconductor, receptor is applied to electrode to produce the signal of stimulating neural tissue with electric impulse signal, plays the effect of treatment.This patent control circuit is relative simple with the realization function, and the controllable channel number is fewer, and the scope of application is little.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, on the basis of the nerve stimulator in the said system being carried out the technological innovation transformation, propose a kind of implanted type programmable nervus stimulator that is applicable to various nerve prosthesis and treatment usefulness.If external what import into is the signal of telecommunication that is converted by acoustical signal and optical signal,, help to become deaf and blind person recovers audition and vision through can be used for artificial cochlea and vision prosthesis after this neural stimulator and the connection electrode; If external what import into is the signal of telecommunication of fixed frequency, through can be used for treatment after this neural stimulator and the connection electrode and alleviating parkinson disease, intractable depression, intractable pain and other special property dyskinesia etc. of sending out.Have characteristics such as the suitability is strong, real-time is high, volume is little, low in energy consumption, powerful.
The present invention is achieved by the following technical solutions, the present invention includes: communications portion, processing controls part and electrode drive part.Wherein, communications portion mainly realizes function that the energy that imports into by wireless radio frequency mode and information are handled; The main FPGA that uses of processing controls part realizes decoding, information distribution and the transmission control of importing information into, the control of electrode drive circuit and the control of power supply; The main analog circuit that uses of electrode drive part produces little curtage, and repeatedly cascade amplifies, and to satisfy the required condition of different stimulated, also realizes the function that the electric charge accumulation is eliminated simultaneously.
Described communications portion comprises energy receiver module, signal processing module, filter rectification module, analog/digital (A/D) modular converter, the energy receiver module receives the energy that sends by wireless radio frequency mode, and sends the processing controls part to realize processing controls part and the electrode drive power supply partly to thereafter behind filter rectification; Signal processing module receives the stimulus information that will carry out that sends by wireless radio frequency mode, and sends the processing controls part to after filter rectification and A/D conversion, and the electrode information that also processing controls is partly transmitted simultaneously is sent to external; The filter rectification module mainly realizes the function to the energy that sends by wireless radio frequency mode and signal filtering and rectification; It will be digital signal through the conversion of signals of filter rectification that analog/digital (A/D) modular converter is realized.
Described processing controls partly comprises signal decoding, information distribution and transmission control module, power supply control and administration module, electrode monitoring and adjustment module.Signal decoding, information distribution and transmission control module receive the stimulus information that sends by communication module, and be broken down into basic control information and stimulus parameter, the numeral and the electrode drive module of control rear end produce the stimulation that needs; Energy supply control module is realized the power supply management to processing controls part and electrode drive part; Electrode monitoring and adjustment module realize the monitoring electrode state, and its situation of change is operated in normal condition by outer adjusting of twireless radio-frequency communication carrier and control circuit to regulate electrode.
Described electrode drive partly comprises numeral and electrode drive module.Numeral realizes that the digital stimulus signal that numerical portion is sent converts analogue signal to, passes to the electrode drive module; The electrode drive module produces the stimulation of satisfying various parameter requests according to transmitting the stimulus signal drive electrode that comes, and also realizes the cumulative elimination function of electric charge simultaneously.
The present invention is according to the electricity irritation theory of nerve stimulation, analyze of the influence of various electric pulse parameters to nerve stimulation, determine the electric pulse polarity of electroshock threshold and selective stimulating, the stimulation signal of telecommunication of generation, comprehensive variform and the stimulation electric impulse signal sequence of various patterns, driving electrode array, directly nerve is carried out functional electric stimulation, be applied to produce artificial hearing, vision, alleviate the condition of illness of Parkinson's disease and depression, alleviate patient's pain, the scope of application is very extensive, has high economic benefit and social benefit.
Shell of the present invention is made of the material with bio-compatibility, and its surface is smooth arc-shaped surface, no sharp corners.Its biocompatible material can be titanium or titanium alloy.
Description of drawings
Fig. 1 is that system of the present invention constitutes block diagram;
Fig. 2 is the formation block diagram of communications portion of the present invention;
Fig. 3 is the formation block diagram of processing controls part of the present invention;
Fig. 4 constitutes block diagram for functional module among the FPGA in the processing controls part of the present invention;
Fig. 5 is the formation block diagram of electrode drive part of the present invention;
Fig. 6 is the electrode drive control circuit figure of electrode drive part of the present invention;
Fig. 7 eliminates circuit diagram for the electric charge accumulation of electrode drive part of the present invention.
The specific embodiment
The present invention proposes a kind of implanted type programmable nervus stimulator, and concrete enforcement is described in detail as follows in conjunction with each accompanying drawing:
System of the present invention constitutes as shown in Figure 1, comprises communication, processing controls and electrode drive three parts.Wherein communications portion links to each other with external control assembly by wireless radio frequency mode, connects thereafter to handle control section, and processing controls part back connection electrode drive part is with driving electrode array.Communications portion provides the information of energy and stimulus signal to numerical portion; The processing controls part had both received the information from communications portion, and control electrode drive circuit drive electrode produces electricity irritation to nerve, again by the monitoring electrode state, spread out of information feedback external to communications portion simultaneously; The stimulus information that the electrode drive part will be imported into is converted into the signal of telecommunication drive electrode that needs and excites nerve, and eliminates stored charge simultaneously, avoids the damage to neural biological tissue.
The composition of the communications portion in the present embodiment comprises energy receiver module, signal processing module, filter rectification module, analog/digital (A/D) modular converter as shown in Figure 2.The energy and the signal that transmit from external reception by the less radio-frequency transmission means respectively of energy receiver module and signal processing module wherein, the energy receiver module is connected with the filter rectification module, and power transfer is given the processing controls part of rear end by this module; Signal processing module also is connected with the filter rectification module, and the processing controls part of digital data transmission being given the rear end through analog/digital (A/D) modular converter. the energy receiver module receives the energy that sends by wireless radio frequency mode, and behind filter rectification, send major control hardware FPGA in the processing controls part to, to realize power supply to FPGA and D/A conversion circuit thereafter, electrode drive circuit; Signal processing module receives the stimulus information that will carry out that sends by wireless radio frequency mode, and sends FPGA to after filter rectification and A/D conversion, also will be sent to external by the electrode information that FPGA transmits simultaneously; The filter rectification module mainly realizes the function to the energy that sends by wireless radio frequency mode and signal filtering and rectification; It will be digital signal through the conversion of signals of filter rectification that analog/digital (A/D) modular converter is realized.
The composition of the processing controls part in the present embodiment as shown in Figure 3, comprising signal decoding, information distribution and transmission control module, power supply control and administration module, electrode monitoring and adjustment module. these three module front ends are connected with communications portion respectively, and the rear end is the connection electrode drive part respectively. and wherein signal decoding, information distribution and transmission control module module, electrode monitoring and adjustment module mainly realize function with FPGA.
Pass through control 8 digital/analog converters (DAC) in the present embodiment, each DAC controls 8 path electrode drive circuits, realize 64 stimulating electrode arrays. wherein the basic comprising among the FPGA is as shown in Figure 4. decoding, information distribution is that the information decomposition that will import into is stimulus information and control information with transmitting control module, respectively stimulus data is sent to the different electrode drive circuit of rear end, satisfy required boost pulse waveform (unipolarity, bipolarity, wherein unipolar pulse also will be considered forward, negative sense), pulse amplitude, pulse duration, pulse number in pulse frequency and the pulse train.Electrode monitoring mainly is the status information of recording electrode with adjustment module, simultaneously the information of record is sent out externally, so that user is adjusted electrode state, makes it be operated in normal condition.8 grades of amplifications are adopted in the control of electrode drive circuit amplification, and promptly the reference current when the rear end electrode drive circuit is 1 MAH, and are maximum scalable to 8 milliamperes.
Power management in the present embodiment and control module mainly be receive by less radio-frequency send energy, its needs by FPGA and back electrode drive circuit are converted into correspondent voltage, satisfy the needs of various piece operate as normal.
The composition of the electrode drive part in the present embodiment comprises the image electric current source and the electric charge accumulation elimination circuit of 8 DAC, 8 grades of amplifications as shown in Figure 5.Wherein the DAC front end partly is connected with processing controls respectively, and the rear end connects the image electric current source respectively, and rear end, image electric current source connects stimulating electrode respectively.8 DAC control 8 image electric current sources respectively, scalable 8 grades at most in totally 64 image electric current sources, each image electric current source.Realize the unipolarity of stimulus signal, the output of bipolar pulse by the field effect transistor of using coupling, its circuit as shown in Figure 6.The selection of signal polarity relies on the control information realization that front end FPGA decomposes out.
Electric charge accumulation in the present embodiment is eliminated circuit as shown in Figure 7.This part circuit design must be because the direct current net charge can be impelled bone tissue growth, destroy the neurocyte tissue with the stimulator handing-over, make implant useless.Simultaneously, the waveform of charge unbalance causes the electrolysis of implant electrode surface.Electrolysis makes material discharge from electrode, can shorten the life-span of electrode.Thereby stimulator must reclaim all electric charges of being sent to electrode preventing the destruction of neurocyte, and guarantees enough implant life-spans.
Claims (6)
1, a kind of implanted type programmable nervus stimulator, comprise: communications portion, processing controls part and electrode drive part, it is characterized in that, communications portion links to each other with external control assembly by wireless radio frequency mode, connect and handle control section thereafter, processing controls part back connection electrode drive part is with driving electrode array, communications portion is handled energy and the information imported into by wireless radio frequency mode, processing controls partly uses on-site programmable gate array FPGA to realize importing the decoding of information into, information distribution and transmission control, the control of electrode drive part and the control of power supply, electrode drive partly uses analog circuit to produce little curtage, and repeatedly cascade amplifies, to satisfy the required condition of different stimulated, also realize the function that the electric charge accumulation is eliminated simultaneously;
Described communications portion comprises energy receiver module, signal processing module, filter rectification module, A/D modular converter, the energy and the signal that transmit from external reception by the less radio-frequency transmission means respectively of energy receiver module and signal processing module wherein, the energy receiver module is connected with the filter rectification module, and power transfer is given the processing controls part of rear end by the filter rectification module; Signal processing module also is connected with the filter rectification module, and digital data transmission is given the processing controls part of rear end through the A/D modular converter.
2, implanted type programmable nervus stimulator according to claim 1 is characterized in that, the electrode information that described signal processing module partly transmits processing controls is sent to external; Described filter rectification module mainly realizes the function to the energy that sends by wireless radio frequency mode and signal rectification and filtering; It will be digital signal through the conversion of signals of rectifying and wave-filtering that described A/D modular converter is realized.
3, implanted type programmable nervus stimulator according to claim 1, it is characterized in that, processing controls partly comprises signal decoding, information distribution and transmission control module, power supply control and administration module, electrode monitoring and adjustment module, these three module front ends are connected with communications portion respectively, the rear end is the connection electrode drive part respectively, signal decoding, information distribution receives the stimulus information that sends by communications portion with the transmission control module, and be broken down into basic control information and stimulus parameter, the numeral and the electrode drive module of control rear end produce the stimulation that needs; Power supply control and administration module are realized the power supply management to processing controls part and electrode drive part; Electrode monitoring and adjustment module realize the monitoring electrode state, and its situation of change is operated in normal condition by outer adjusting of twireless radio-frequency communication carrier and control circuit to regulate electrode.
4, implanted type programmable nervus stimulator according to claim 1, it is characterized in that, electrode drive partly comprises numeral and electrode drive module, the numeral front end connects handles control section, rear end connection electrode driver module, connection electrode array after the electrode drive module, numeral realize that the digital stimulus signal that numerical portion is sent converts analogue signal to, passes to the electrode drive module; The electrode drive module produces the stimulation of satisfying various parameter requests according to transmitting the stimulus signal drive electrode that comes, and also realizes the cumulative elimination function of electric charge simultaneously.
5, implanted type programmable nervus stimulator according to claim 1 is characterized in that, shell is made of the material with bio-compatibility, and its surface is smooth arc-shaped surface.
6, implanted type programmable nervus stimulator according to claim 5 is characterized in that, biocompatible material is titanium or titanium alloy.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100256583A CN100434126C (en) | 2006-04-13 | 2006-04-13 | Implanted type programmable nervus stimulator |
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| CNB2006100256583A CN100434126C (en) | 2006-04-13 | 2006-04-13 | Implanted type programmable nervus stimulator |
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| CN100434126C true CN100434126C (en) | 2008-11-19 |
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| CN101244312B (en) * | 2007-02-16 | 2012-06-20 | 上海塔瑞莎健康科技有限公司 | Implantation type self-feedback regulating nerve muscle electrostimulation system |
| CN101234227B (en) * | 2007-12-28 | 2012-01-18 | 中国人民解放军第三军医大学野战外科研究所 | Implantation type wireless limbs sport control nerve stimulation network system |
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| CN105496643B (en) * | 2016-01-18 | 2017-05-31 | 戴国群 | Acquired blindness patient visual recovers lost eyesight intelligent object wearing device and its manufacture method |
| CN109960182A (en) * | 2017-12-22 | 2019-07-02 | 深圳市上示科技有限公司 | A kind of signal generation apparatus and the equipment with signal generation apparatus |
| CN109621223A (en) * | 2019-01-30 | 2019-04-16 | 广东工业大学 | A kind of light stimulus system |
| CN110597340A (en) * | 2019-10-14 | 2019-12-20 | 无锡益碧医疗科技有限公司 | Bidirectional constant-current pulse driving system for electrical stimulation treatment |
| WO2021102733A1 (en) * | 2019-11-27 | 2021-06-03 | 深圳先进技术研究院 | Visual prosthesis apparatus and system, control method and related device |
| CN116440408B (en) * | 2023-03-17 | 2024-01-09 | 上海杉翎医疗科技有限公司 | Implantable stimulation systems, methods, implantable devices, and storage media |
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