CN100475137C - Integrated multi-rail imaging system - Google Patents
Integrated multi-rail imaging system Download PDFInfo
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- CN100475137C CN100475137C CN 200380105066 CN200380105066A CN100475137C CN 100475137 C CN100475137 C CN 100475137C CN 200380105066 CN200380105066 CN 200380105066 CN 200380105066 A CN200380105066 A CN 200380105066A CN 100475137 C CN100475137 C CN 100475137C
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Abstract
The imaging system can comprise a plurality of elongated rails, a scanhead assembly, and a small animal mount assembly. The scanhead assembly is selectively mounted onto a first rail and is constructed and arranged for movement in a linear bi-directional manner along the longitudinal axis of the first rail. The small-animal mount assembly is selectively mounted onto a second rail and is constructed and arranged for movement in a linear bi-directional manner along the longitudinal axis of the second rail. The second rail being mounted relative to the first rail such that the longitudinal axis of the second rail is at an angle to the longitudinal axis of the first rail. The small-animal mount assembly can include a table member suitable for mounting a small animal. The table member can be selectively positionable into a desired table plane. The imaging system can also comprise a needle injection assembly that is selectively mounted onto the third rail and is constructed and arranged for movement in a linear bi-directional manner along the longitudinal axis of the third rail. The third rail being mounted relative to the second rail and the first rail such that the longitudinal axis of the third rail is substantially coaxial to the longitudinal axis of the first rail.
Description
Related application is quoted alternately
The application requires the priority and the interests of following application: on October 10th, 2002, that file an application, title was the U.S. Provisional Application NO.60/417 of " GUIDED INJECTED RAIL SYSTEM (guiding injection track system) ", (attorney docket NO.00518-0008), 167; On May 9th, 2003, that file an application, title was the U.S. Provisional Application NO.60/468 of " GUIDEDINJECTION RAIL SYSTEM (guiding injection track system) ", (attorney docket NO.T00518-0008-USP2), 959; On October 10th, 2002, that file an application, title was the U.S. Provisional Application NO.60/417 of " SMALL ANIMAL SURGICALINTERVENTION PLATFORM (toy surgical operation platform) ", (attorney docket NO.T00518-0009), 185; And on May 9th, 2003 is that file an application, title is the U.S. Provisional Application NO.60/468 of " SMALL ANIMAL SURGICALINTERVENTION APPARATUS (toy surgery device ", (attorney docket NO.T00518-0009-USP2), 960, all these patent applications here by reference mode are all included in the presents.
Background of invention
Invention field
The present invention relates to a kind of small animal imaging system, more particularly, relate to a kind of planar multi-rail imaging system of desired image that is used for during imaging, keeping.
Description of the Prior Art
In several years in the past, the researcher of the different subjects as neuroscience, developmental biology, hereditism and oncology makes great efforts to capture to the zone of dispersion injection microlitre of tract and the fluidic difficult problem of millilambda amount.Along with development and its enforcement in small animal imaging market of ultrasound biomicroscopy UBM (UBM) technology, non-invasively Real Time Observation pin or probe become a reality with respect to the position of organ.A shortcoming of present animal navigation system is impossible carry out simple directly repetition at different animals to its position.
For example, in injection process, it is exactly a common difficult problem that the fluidic needle guide of injection minute quantity is aimed at UBM probe equipment to equipment.In order to help to guarantee that needle guide is arranged in same plane so that the operator can guide to the tissue of being studied with needle guide to the syringe needle and the ultrasound scanning head of equipment, is necessary these two equipment are carried out micromanipulation.Therefore, this process is not only required great effort but also time-consuming, in the time will scanning a different animals, these two equipment all need be removed from the fixing animal handling facilities of toy, make more require great effort time-consuming.Present system uses independently being used for distinct device during the imaging, non-integrated localization method.
Many information and expertise can obtain by mouse genomic sequence with to the manipulation of mouse gene group.Because mouse gene group and human genome have similarity, thus with mouse as model understanding human gene function, and with the model of mouse as many human disease processes.The guiding manipulation that injection technique allowed makes that further understanding genome functions, allelotaxis's function sexual stage and the difference of stem cell becomes easily, and makes test become easy at the new intervention (intervention) of human diseases model.Because ultrasonic imaging can be used for generating in real time high-resolution cross sectional image, so can operate imaging system when pin is guided in the toy, this offers operator's feedback promptly and accurately so that needle point is positioned at the target area.Yet, need a kind of system so that handle imaging device and injection device (if using injection device) fast with efficient way at a series of different animals.
Also need a kind of during imaging with produce minimum pressure and efficiently mode load and unload the stationary work-table of toy, for example, mice, rat, rabbit and similar toy.The control of animal physiological condition is most important, but will allow the object that is fixed to carry out this control in the environment of a plurality of diverse locations motions so that animal is placed on success rate maximum in the imaging plane of imaging device a kind of.In fact, in order to improve imaging resolution, some drafts need be with the embryo of pregnant animal from the abdominal part externalizing, and this has further made these complex procedures changes.
Up to now, the various needs that also do not have equipment to satisfy to summarize below: anaesthetize toy safely and effectively, implement physiology monitoring, have a range of movement and for the object that is fixed successfully with the ability of embryo's externalizing on dedicated.
Summary of the invention
Imaging system of the present invention is convenient to the productivity imaging of toy.In an example, this imaging system can comprise a plurality of elongated rails, a scanning head assembly and a small-animal mount assembly.In the another one example, this imaging system also comprises the pin injecting assembly.
Described a plurality of elongated rails can comprise first track, second track and the 3rd track (if use).Each track all has near-end, the far-end and the longitudinal axis of spacing is arranged.In a demonstration structure, the near-end of first track contiguous second track, in the near-end of second track and first edge between the far-end, the longitudinal axis of the longitudinal axis of such first track and second track is angled.In the another one demonstration example, the near-end of the 3rd track contiguous second track, in the near-end of second track and second edge between the far-end, such the 3rd track and first track are at two opposite sides of second track.In this example, the longitudinal axis of the 3rd track is basic coaxial with the longitudinal axis of first track.
Scanning head assembly optionally is installed on first track, and is constructed and arranged to the longitudinal axis that is suitable for along first track and moves with linear bidirectional mode.The small-animal mount assembly optionally is installed on second track, and is constructed and arranged to the longitudinal axis that is suitable for along second track and moves with linear bidirectional mode.The pin injecting assembly optionally is installed on the 3rd track, and is constructed and arranged to the longitudinal axis that is suitable for along the 3rd track and moves with linear bidirectional mode.
Small-animal mount assembly of the present invention is applicable to installs toy thereon, to carry out desired medical and imaging process.In an example, the small-animal mount assembly have control device, table member and at least one ECG control pad with help monitoring the health status of fixed toy.Table member has end face and defines table plane.In an example, table member can optionally be directed so that the table plane of table member can be positioned in the desired table plane.
The accompanying drawing summary
These and other features of the preferred embodiments of the invention will become more obvious in the following detailed description that the reference accompanying drawing carries out, wherein:
Fig. 1 is the perspective view of an embodiment of small animal imaging of the present invention system, has shown the scanning head assembly that is installed on first track and has been installed to small-animal mount assembly on second track.
Fig. 2 is the perspective view of an alternate embodiment of small animal imaging of the present invention system, has shown the scanning head assembly that is installed on first track, is installed to the small-animal mount assembly on second track and has been installed to pin injecting assembly on the 3rd track.
Fig. 3 is the sketch map of toy imaging system among Fig. 2.
Fig. 4 is the side view of toy imaging system among Fig. 2.
Fig. 5 is the perspective view of first or the 3rd track of the present invention.
Fig. 6 is the perspective view of active block stop.
Fig. 7 is the exploded view of active block stop among Fig. 6.
Fig. 8 is the perspective view of an embodiment of second track of the present invention, has shown two fixed stops that spacing is arranged.
Fig. 9 is the perspective view that is installed to the scanning head assembly on first track, has shown fixed mount and scanhead unit.
Figure 10 is the perspective view of the base component of scanning head assembly, has shown at least one slide that is connected to the base component bottom.
Figure 11 is the perspective view of stay, cantilever beam and the scanhead orientation controlling organization of the elongation of scanning head assembly among Fig. 9.
Figure 12 is the exploded view of stay, cantilever beam and the scanhead orientation controlling organization of elongation shown in Figure 11.
Figure 13 is the perspective view that is installed to the small-animal mount assembly on second track.
Figure 14 is the perspective view of small-animal mount assembly among Figure 13.
Figure 15 is the top view of small-animal mount assembly among Figure 13.
Figure 16 is the side view of small-animal mount assembly among Figure 13.
Figure 17 is the side view of small-animal mount assembly among Figure 13.
Figure 18 is the perspective view of base component of the holder sub-component of small-animal mount assembly shown in Figure 13.
Figure 19 is the exploded view of base component shown in Figure 180.
Figure 20 is the perspective view of the surface platform of holder sub-component.
Figure 21 is the perspective view of a part of the table orientation controlling organization of holder sub-component.
Figure 22 is the perspective view of die cavity of the directed controlling organization of small-animal mount assembly, has shown the part of directed controlling organization.
Figure 23 is the perspective view of die cavity of the directed controlling organization of small-animal mount assembly, has shown the part of directed controlling organization.
Figure 24 is the perspective view of die cavity of the directed controlling organization of small-animal mount assembly, has shown the part of directed controlling organization.
Figure 25 is the top view of the die cavity of directed controlling organization among Figure 24.
Figure 26 is the perspective view of the part of directed controlling organization.
Figure 27 is the perspective view of the part of directed controlling organization.
Figure 28 is the perspective view of the part of directed controlling organization, has shown the part of the die cavity that disassembles.
Figure 29 is the perspective view of the part of directed controlling organization, has shown the part of the die cavity that disassembles.
Figure 30 is the perspective view of a part that is operably connected to the directed controlling organization of table member.
Figure 31 is the exploded view of Fig. 6.
Figure 32 is the side view that is installed to an embodiment of the pin injecting assembly on the 3rd track, has shown syringe sub-component and slide sub-component.
Figure 33 is the perspective view of pin injecting assembly among Figure 28.
Figure 34 is the rotation regulating mechanism of slide sub-component and the perspective view of height adjustment mechanism.
Figure 35 is the exploded view of rotation regulating mechanism and height adjustment mechanism among Figure 34.
Figure 36 is the perspective view of first lateral adjustment, second lateral adjustment, first tilt adjustment mechanism and second tilt adjustment mechanism of slide sub-component.
Figure 37 is the exploded view of first lateral adjustment among Figure 36, second lateral adjustment, first tilt adjustment mechanism and second tilt adjustment mechanism.
Figure 38 is the perspective view of the part of hinged armature sub-component, has shown substructure member.
Figure 39 is the perspective view of a plurality of cooperative arm members of hinged armature sub-component.
Figure 40 is the partial cross section figure of pin injecting assembly.
Figure 41 is the partial cross section figure of the part of syringe part.
Figure 42 is the perspective view of the syringe part of syringe sub-component.
Figure 43 is the exploded view of syringe part among Figure 42.
Detailed Description Of The Invention
The present invention will obtain more detailed description in following example, these examples only are illustrative, because wherein many change body and modification will be tangible to one skilled in the art.Therefore, describing the embodiment of the present invention that illustrate with example here is not in order to carry out exhaustive or to limit the invention to disclosed precise forms.Selecting these examples is in order to describe or explain best the application and the practical use of principle of the present invention and it, thereby makes others skilled in the art can utilize the present invention best." a " that uses in description and claim, " an " and " the " can refer to one or more, decide according to its residing context.Describe preferred embodiment referring now to figure, same numbers is represented the same section among all figure in the drawings.
With reference to Fig. 1, show an embodiment of integrated multi-rail imaging system 10 of the present invention.This imaging system comprises a plurality of elongated rails 30, optionally is installed to the scanning head assembly 100 on first track 32 in described a plurality of elongated rails and optionally be installed to small-animal mount assembly 200 on second track 34 in described a plurality of elongated rails.In an alternate embodiment shown in Fig. 2-4, imaging system 10 can also comprise the pin injecting assembly 400 on the 3rd track 36 that optionally is installed in described a plurality of elongated rails.
As noted above and go out as shown in FIG., described a plurality of elongated rails 30 comprise first track 32, second track 34 and, if use pin injecting assembly 400, the three tracks 36.Each track all has near-end 35 and the far-end 37 of spacing is arranged, and has longitudinal axis R1, R2 and R3 respectively.Each track 30 can by welding or utilize such as, for example, the conventional fasteners of screw, bolt or other similar things and so on is connected on the strip gripper shoe 40.Each gripper shoe can have such as, for example, at least one shock absorber part 42 of rubber feet and so on, shock absorber part 42 are connected with the bottom of gripper shoe and extend from here to help to reduce vibration.Scanning head assembly 100, small-animal mount assembly 200 and pin injecting assembly 400 have base component 102,202 and 402 respectively, base component all is constructed and arranged to and is suitable on its track separately with linear bidirectional mode, promptly along the longitudinal axis of track separately, with back and forth or the motion of other slip mode.Will be understood that each base component has at least one slide 44 that is connected with the bottom of this base component, this base component is applicable on track separately and slides.In one embodiment, each track can also have the fixed stop 50 that is connected with the far-end of this track, is installed to the motion of the base component on it with restriction.In an alternate embodiment, second track can have a pair of fixed stop 51, and fixed stop 51 is connected and limits two fixed endpoints of base component 202 two-way travel with second track.
In the use, the end limit 46 of the gripper shoe 40 that is connected with first track 32 and the side 48 of the gripper shoe that is connected to second track 34 ' be connected.The near-end 35 of first track 32 is between the position and near-end 35 and far-end 37 at second track of contiguous second track 34.In this structure, the longitudinal axis of the longitudinal axis of first track and second track is angled.In one embodiment, angle γ spends between 30 degree about 150 greatly.In another embodiment, angle γ spends between 60 degree about 130 greatly.In another embodiment, angle γ spends between 70 degree about 110 greatly.In a further embodiment, angle γ spends between 85 degree about 95 greatly.
If use, " (relative with the side that is connected to first track 32) is connected to be connected to the side 48 of end limit 46 and the base plate of second track 34 of base plate 40 of the 3rd track 36.The near-end 35 of the 3rd track 36 is between the position and near-end and far-end at second track of contiguous second track, and such the 3rd track 36 is relative with first track, 32 positions.In this example, the remote extension of relevant first track and the 3rd track is away from the longitudinal axis almost coaxial of the other side and first track and the 3rd track.Therefore, relevant longitudinal axis R1, R2 and R3 are fixed on the relative orientation relative to each other, so that a common coordinate system to be provided.
Each active block stop 52 also have can be optionally fixedly active block stop with respect to the lock actuater 54 of the position of track component.Will be understood that the Systems Operator can be by discharging lock actuater, active block stop is moved to the position of expectation and utilizing lock actuater active block stop to be locked to the position of easily regulating active block stop on the track in the position of expectation.Base component 102,202 can optionally releasably be fixed on the part of a relevant active block stop with a part of 402.
In an example, the part of base component and the part of active block stop are geomagnetic into the polarity of attracting each other, and when closer to each other, the relative section of base component and active block stop is attracted each other like this.In the another one example, the second portion of each base component and the part of fixed stop also are geomagnetic into the polarity of attracting each other, and when closer to each other, this part of the second portion of base component and fixed stop is attracted each other like this.Therefore, in use, mobile foundation member between fixed stop and active block stop optionally, and can base component releasably be fixed on the active block stop in the position of expectation.This allows optionally to regulate an end points of the stroke of base component, and allows selected desired locations is removed and be moved back into to base component fast, promptly gets back to the optional end points of stroke.
Scanning head assembly
With reference to figure, scintigram assembly 100 comprises fixed mount 110 and scanhead unit 130.Fixed mount 110 comprises stay 112, cantilever beam 114 and the scanhead unit orientation controlling organization 160 of base component 102, elongation.Stay 112 is connected to (being installed to as mentioned above on first track) base component 102 and is basically perpendicular to base component 102 and extends.Cantilever beam 114 has first end 116 and second end 118 of spacing is arranged.Second end 118 of beam has shroud member 120, and shroud member 120 is constructed and arranged to and is suitable on the outer surface 113 of stay 112 with linear bidirectional mode, promptly along the longitudinal axis of stay, with back and forth or the motion of other slip mode.The longitudinal axis coplane of the longitudinal axis of beam 114 and first track 32.
The shroud member 120 of beam also has the beam locking mechanism 122 that is used for optionally this shroud member being installed in desired locations.For example, in use, the handle 124 that can rotate this beam locking mechanism can or be reduced to desired locations with the beam rising, and the handle 124 of rotating beam locking mechanism 122 is optionally to lock onto desired locations with beam with respect to stay 112 to unclamp the beam locking mechanism.In an example, the outer surface 113 of stay 112 defines at least one longitudinal extension groove 115, and the inner surface 121 of shroud member 120 has at least one convex tendon 123.This convex tendon has the complementation that certain size and dimension is used in a groove 115 of stay and receives.In an example, the length direction of the local at least inner surface 121 along shroud member of convex tendon 123 extends.
In an example, scanhead unit 130 is a ultrasound scanning head.Yet, will be understood that also and can use other scanhead unit, for example, such as MRI probe, CT scan head and other similar things.Scanhead unit 130 is electrically connected to the outer computer 20 that is used to handle image.Scanhead unit 130 is operably connected to the beam 112 of scanning head assembly 100 on the orientation of selecting by scanhead unit orientation controlling organization 160.In an example, the scanhead unit orientation controlling organization comprises angle control locking mechanism 162 and ball joint lock mechanism 170.The near-end 164 of angle control locking mechanism 162 is connected to beam in the position near first end 116 of beam.The standing part of angle control locking mechanism is along vertical axially the extending away from beam down of cardinal principle.The far-end 166 of angle control locking mechanism is connected to the near-end 172 of ball joint lock mechanism 170, and is constructed and arranged to and is suitable for angle that ball joint lock mechanism limits along the coplane longitudinal axis by first track and beam and controls lock plane and do pivoting action.It should be understood that angle can be controlled locking mechanism 160 moves between locked.
The far-end 174 of ball joint lock mechanism 170 is connected with scanhead unit, and is constructed and arranged to and is suitable for scanhead unit and does pivoting action.Will be appreciated that ball joint lock mechanism 170 allows the operating side 132 of scanhead unit to be positioned at certain angle with respect to the vertical axes of angle control locking mechanism with respect to angle control lock plane.Ball joint lock mechanism 170 can move between locked.When ball joint lock mechanism 170 is locked in expected angle, will be appreciated that, by optionally release angle control locking mechanism 160 and with angle control locking mechanism along its fixedly range of movement move, can be on the desired image plane along the operating side 132 of one section arc motion scan head member 130.
The small-animal mount assembly
Small-animal mount assembly 200 of the present invention comprises workbench sub-component 210 and holder sub-component 260.Workbench sub-component 210 comprises table member 212.Holder sub-component 260 comprises the base component 202 that is installed to as mentioned above on second track 34, surface platform 262 and optionally is placed on table orientation controlling organization 280 on the part of upper surface 264 of platform 262.Table orientation controlling organization 280 is constructed and arranged to and is suitable for regulating height, gradient and the rotation with respect to the upper surface 264 of platform 262 of the table member 212 that is operably connected.
In an example, the optional plunger lock mechanism 206 of operator is connected to the edge of base component 202.The part of plunger lock mechanism is constructed and arranged to a part that is suitable for optionally engaging the fixed stop 51 that is connected to second track.Plunger lock mechanism can comprise spring mechanism, and this spring mechanism is used for applying power for plunger lock mechanism 206 up to the operator to relevant fixed stop plunger lock mechanism " locking ".During use, the operator upwards draws plunger lock mechanism so that plunger lock mechanism is separated with relevant fixed stop.Then, can optionally be locked onto on another fixed stop until it along the longitudinal axis mobile foundation member 202 of second track.In this example, a fixed stop 51 is positioned at the position of the far-end of contiguous second track, and another fixed stop 51 is between the near-end and far-end of second track.
In an example, platform 262 movably is connected to base component 202 by platform adjustment mechanism 270.Platform 262 has and upper surface opposing lower surface 266, and defines first A1 of the longitudinal axis that is parallel to second track and perpendicular to second A2 of first.Platform can also have substantially the raised brim 268 of stretching out around the platform periphery in case fastening falls to the upper surface 264 of controlling organization from platform.
In this example, the lower surface 266 of platform can be placed on the end face 204 of base component 202.And the end face 204 of the upper surface 264 of platform, lower surface 266 and base component is positioned at parallel plane.Such as, for example, the low-friction material coating of Teflon TM and so on or thin layer (sheet) can cover the lower surface 266 of platform or the end face 204 of base component 202.Those skilled in the art will be appreciated that, can expect other low-friction materials.Therefore, during use, can optionally in platform plane, move along first and second at the control lower platform of platform adjustment mechanism 270.This motion can take place with the friction of minimum in low-friction coating.
Can be around placing die cavity 282 interior bearings 312 to center on the column component 300 of vertical axes spin orientation controlling organization.Rotation brake mechanism 310 is placed in the die cavity, and is constructed and arranged to and is suitable for optionally engaging the braking surface 314 that is connected to column component, so that column component can be fixed on desired locations with respect to vertical axes.Therefore, can the Rotary cloumn member by apply revolving force to column, can be on the orientation of expectation until table member around the vertical axes rotation with the table member that column component operationally engages like this.When column component is positioned at desired locations, can optionally start rotation brake mechanism 310, pass the stop knob 314 that stretches out the die cavity outside optionally column component is fixed to desired locations with respect to vertical axes.
In this structure, the y axle of the table plane that the first gradient controlling organization 330 is relevant relatively with the second gradient controlling organization, 340 permission table member 212 and x axle are at angle.In one embodiment, this angle less than and comprise about 60 degree (that is, just/negative 30 degree).In another embodiment, this angle less than and comprise about 45 degree (that is, just/negative 22.5 degree).In another embodiment, this angle less than and comprise about 30 degree (that is, just/negative 15 degree).Therefore, in the operation, the control of optionally handling holder sub-component 260 by the operator makes table member 212 can be oriented to the table surface plane of expectation.
Electronic heating element grid 230 is placed on the end face 214 of table member 212, and is electrically connected to control device 250.Therefore the temperature of the end face 214 of table member can be regulated via control device, the temperature of toy can be remained in the scope of expectation when toy is placed on the end face 214 of table member.When using thermocouple 240, thermocouple 240 is connected with the end face of table member and can be positioned, and when toy was fixed on the end face 214, the part of toy covered on the thermocouple like this.In an example, thermocouple is placed near the center of end face 214 of table member 212, and separates with described at least one electronic heating element grid 230.Thermocouple 240 produces the temperature signal 242 of the temperature of the toy of representing detected close thermocouple.This temperature signal 242 can be transferred to control device 250 by temperature signal circuit 244 via the A/D converter (not shown).This temperature signal can or be simulated the transmission of frequency overlapped-resistable filter (not shown) to eliminate noise and amplifying signal before handling via isolated amplifier and numeral.
In an example, if outer embryo's imaging is carried out in expectation, workbench sub-component 210 can comprise dish 360 and the dish supporting mechanism 370 of being with wall.Dish 360 has surrounding wall 362, and defines hole 364 in the bottom of dish.Dish is made by the inflexible material of cardinal principle, for example, and such as rigid plastics.The flexible partition 366 that defines otch 368 is connected with the hole to form moistureproof the connection.In an example, the otch in the slack position barrier film is closed and is moistureproof.Otch in the stretch position barrier film opens.Flexible partition can be a diaphragm of rubber.In the another one example, the otch 368 in the barrier film 366 all opens in slack position and stretch position.
By driving-disc supporting mechanism 370 optionally, can optionally dish 360 end faces 214 with respect to table member 212 be fixed on the appropriate location.The dish supporting mechanism has arm member 372 and fastener 374.Arm member has top 376, and top 376 is constructed and arranged on the part of the wall 262 that is suitable for optionally being locked to dish.Will be appreciated that, dish 260 can be unloaded by dismounting milled screw 378.Arm member 372 has the bottom of the groove 379 of the elongation of defining.Fastener 374 is by groove 379 and can be optionally the bottom of arm member be fixed on the edge of table member.During use, by unclamping fastener 374, will coiling 360 and be adjusted to desired locations and tighten fastener 374 and be fixed on the position that described desired locations just can be regulated additional disk will coil 260.
In some externalized procedures, toy is fixed on the end face 214 of table member, and coils 260 and be placed on the toy, so flexible partition 366 is in the stretching deployed position, and the otch of " opening " forms moisture seal between toy and dish.In this example, the embryo can by the otch in the diaphragm of rubber and still with dish that toy links to each other in imaging.
The pin injecting assembly
With reference to Figure 32-43, show an embodiment of pin injecting assembly 400.The pin injecting assembly is constructed and arranged to insertion point, insertion depth and the angle of penetration that is suitable for the operator and controls pin.Pin injecting assembly 400 can also be constructed and arranged to the pin piston 433 that is suitable for controlling pin 432.
In an example, pin injecting assembly 400 comprises (being connected to as mentioned above on the 3rd track 36) base component 402, syringe sub-component 420 and slide sub-component 450.Syringe sub-component 420 comprises syringe part 430, and syringe part 430 has the pin 432 that is operably mounted into elongation wherein.Pin 432 has longitudinal length and terminal 434.Slide sub-component 450 is connected with base component 402, and be provided in desired plane, being provided with the control of the insertion point of pin on toy, wherein the general and scanhead unit of desired plane is assembled with the plane of carrying out imaging to be same plane, promptly to expect the plane of delineation.Slide sub-component 450 also is provided for the control of pivot rotation pin 432, so that the operator can be provided with the expectation angle of penetration of the insertion point of pin on toy.Slide sub-component 450 can comprise rotation regulating mechanism 460, height adjustment mechanism 470, first lateral adjustment 480, second lateral adjustment 490, first tilt adjustment mechanism 500, second tilt adjustment mechanism 510 and hinged armature sub-component 530.
Rotation regulating mechanism 460 is constructed and arranged to the part that is suitable for being installed to around the vertical axes rotation slide sub-component on it.In an example, rotation regulating mechanism comprises the die cavity 462 that is connected with the end face 404 of base component 402.Rotation regulating mechanism 460 also comprises the plain bearing 464 that is installed in the die cavity, and wherein die cavity is connected to and support frame member 465.Framing component 465 has the pedestal 467 that is operably connected with the bearing of rotation regulating mechanism.Will be appreciated that framing component 465 can extend and extend through the vertical axes rotation at the center of bearing around the longitudinal axis perpendicular to the 3rd track.Rotation regulating mechanism 460 can comprise and is used for the optionally spin locking knob 466 of the rotation of latch frame member, so that the limiting frame member is with respect to the rotation amount of vertical axes.Rotation regulating mechanism can also comprise accurate adjustment rotation adjusting control handle 468, and control handle 468 makes the operator after the spin locking knob has been engaged framing component be rotated a limited angle around vertical axes.In one embodiment, limited angle (just/negative 5 is spent) between 10 degree greatly.In another embodiment, this angle (just/negative 4 is spent) between 8 degree greatly.In another embodiment, this angle (just/negative 3 is spent) between 6 degree greatly.
First lateral adjustment 480 is connected to and is installed on the upper surface 476 of platform 472.Second lateral adjustment 490 is connected to and installs the optionally movable top surface 482 of first lateral adjustment 480 thereon.First tilt adjustment mechanism 500 is connected to and installs the optionally movable top surface 492 of second lateral adjustment 490 thereon.Equally, second tilt adjustment mechanism 510 is connected to and is installed on the optionally movable top surface 502 of first tilt adjustment mechanism 500.Hinged armature sub-component 520 is operably connected with the optionally movable top surface 512 of second tilt adjustment mechanism 510.
First lateral adjustment 480 is constructed and arranged to and is suitable for the end face 482 of first lateral adjustment with respect to platform 472 and be parallel to the x axle that this platform limits and move.This make the lateral adjustment 480 of winning end face 482 can towards or the near-end of carrying the 3rd track 36 move.In the use, rotate the end face 482 that first lateral adjustment knob 484 makes first lateral adjustment 480 and move with respect to platform is two-way.Equally, second lateral adjustment 490 is constructed and arranged to and is suitable for the end face 492 of second lateral adjustment with respect to the end face 482 of first lateral adjustment 480 and be parallel to the y axle (it is perpendicular to the x axle that is limited) that platform limits and move.This make second lateral adjustment end face 492 can towards or the relevant side of carrying the 3rd track 36 move.In the use, rotate end face 492 that second lateral adjustment knob 494 makes second lateral adjustment end face 482 two-way moving with respect to first lateral adjustment.Will be appreciated that, in the another one example, second lateral adjustment 490 can be connected to and be installed on the end face 476 of platform 472, and first lateral adjustment 480 can be connected to and install the optionally movable top surface 492 of second lateral adjustment 490 thereon then.
Hinged armature sub-component 520 has substructure member 522, and in an example, substructure member 522 is connected with the end face 512 of second tilt adjustment mechanism 510.The substructure member 522 of hinged armature sub-component defines base plane, and this base plane further defines x axle and y axle.Will be appreciated that the x axle of base plane and y axle form a common coordinate system.In an example, first tilt adjustment mechanism 500 is operably connected to the end face 492 of second lateral adjustment 490, and be constructed and arranged to be suitable for optionally regulating with firm banking member 522 with respect to gradient around the y axle of substructure member.Second tilt adjustment mechanism 510 is operably connected to the end face 502 of the first gradient mechanism 500, and is constructed and arranged to and is suitable for optionally regulating and the gradient of firm banking member 522 with respect to the x axle of substructure member.
In this structure, first tilt adjustment mechanism 500 and second tilt adjustment mechanism 510 make the substructure member 522 can be with respect to the y axle of relevant substructure member and x axle at angle.In one embodiment, this angle less than and comprise about 40 degree (that is, just/negative 20 degree).In another embodiment, this angle less than and comprise about 20 degree (that is, just/negative 10 degree).In another embodiment, this angle less than and comprise about 10 degree (that is, just/negative 5 degree).
Will be appreciated that in another example, second tilt adjustment mechanism 510 can be connected to and install the uppermost optionally movable top surface of first or second lateral adjustment thereon.In this example, first tilt adjustment mechanism 500 is connected to and is installed to the optionally movable top surface 512 of second tilt adjustment mechanism 510.The substructure member of hinged armature sub-component 520 will be operably connected with the optionally movable top surface 502 of first tilt adjustment mechanism.
Hinged armature assembly 520 comprises and is operably connected with substructure member and can drives a plurality of cooperative arm members 530 that move by the selectivity of armature controlling organization 524.Will be appreciated that, optionally handle rotation regulating mechanism 460, height adjustment mechanism 470, first lateral adjustment 480, second lateral adjustment 490, first tilt adjustment mechanism 500 and/or second tilt adjustment mechanism 510 and make the substructure member 522 of hinged armature assembly can be positioned at the base plane of expectation, the base plane of described expectation is limited by the plane of running through this substructure member.The syringe part 430 of syringe sub-component 420 operationally is installed in the bearing 532 of the end portion 534 that is positioned at described a plurality of cooperative arm members, and the end 434 of pin 432 extends beyond described a plurality of cooperative arm members like this.Will be appreciated that syringe part 430 is positioned at the pin plane perpendicular to the base plane of substructure member 522.
Hinged armature assembly 520 is constructed and arranged to the end 434 rotary injection device parts 430 that are suitable for centering on pin in perpendicular to the expectation pin plane of expectation base plane.During operation, the basic and desired image plane coplane in expectation pin plane.When rotating armature control handle 526 optionally, syringe part becomes with respect to vertical axes between first fixed endpoint and second fixed endpoint of pin 432 when becoming a higher angle of penetration θ with respect to vertical axes during than low penetration angle θ at pin 432.Therefore, the operator can optionally be provided with the accurate insertion point of pin, and can select pin to enter the expectation angle of penetration θ that is studied toy in expectation pin plane by the control of handling hinged armature assembly.Hinged armature assembly 520 also comprise can optionally engaged position brake mechanism 540 with in the fixing described a plurality of cooperative arm members of desired locations.By " fix " described a plurality of cooperative arm members at desired locations, the operator can " fix " the expectation angle of penetration θ of pin.By knob 542 being tightened onto on the part of base member, can with described a plurality of cooperative arm members optionally " lock " to the appropriate location.
The syringe sub-component comprises that also pin inserts mechanism 540, and pin inserts mechanism 540 and is constructed and arranged to and is suitable for controlling syringe part 430 with respect to the release of the bearing 532 of described a plurality of cooperative arm members 530 with draw back.In the use, the pin that the rotation pin inserts mechanism inserts control handle 542 makes syringe part 430 and attached thereon pin move along bearing and along the longitudinal axis of pin 432 is two-way.Will be appreciated that, syringe part and attached thereon pin insertion or draw back control handle 542 is inserted in motion by pin direction of motion decision.
Will be appreciated that the combination of the releasable connection between the base component of movable/fixed stops, each assembly and each track allows to reorientate assembly in aligning that keeps different parts and relative localization.Assembly can be assembled and aims in their procedure position separately, and subsequently they be shifted out from the appropriate location, for example, to replace the toy on the table member.Assembly can be put back to their procedure position then, and with at the employed same way as of toy before on the table member with assembly alignment.Will recognize that, can avoid the time-consuming process of potential alignment components again in this way.
Because the small-animal mount assembly can be published picture as the plane on its track in slippage, so, in case the toy on the table member is by imaging (with being injected), just can be by using movable/fixed stops that scanhead unit or syringe part (if use) are done minimal adjustment easily with in second toy importing visual field.
Imaging system 10 can also comprise the computer 20 with system processor 22.Processor 22 can be connected to display or monitor 24 and the user input apparatus 26 such as keyboard, mouse or other appropriate device.If it is quick that monitor 24 touches, monitor 24 itself can be used as user input apparatus 26 so.Computer readable storage medium 28 is connected to processor.Will be appreciated that, can pass through the operation of the workbench sub-component 210 and the pin injecting assembly 400 (if use) of computer 20 a gated sweeps assembly 100, small-animal mount assembly 200.Those skilled in the art can understand, and computer readable medium 28 can comprise hardware and/or software, only gives an example, as disk, tape, light readable medium such as CD-ROM and the semiconductor memory such as pcmcia card etc.In each example, media 28 can adopt the form of the portable product such as minidisk, floppy disk, tape, and perhaps it can adopt such as hard disk drive, solid-state memory card or be connected to form bigger or fixed product the RAM of processor 22.It should be noted that the example of above-named media 28 can use separately or be used in combination.Display 24 can be multiduty, and is used as the screen of imaging system 10.Perhaps, imaging system can have independent screen.
System when beginning operation places toy and be fixed on and makes the claw of toy place against the ECG pad on the table member.Insert transrectal probe in the petty action object and during whole imaging, monitor health parameters by control device 250 and/or computer 20.Optionally handle the small-animal mount assembly the holder sub-component each control so that table member is placed in the table surface plane of expectation.In an example, can mobile small-animal mount assembly on second track until plunger lock mechanism 206 with engage at the near-end of second track and the part of the fixed stop between the far-end 51.Perhaps, can mobile small-animal mount assembly contact with the part of active block stop on placing second track in advance until the part of base component.In this position, the table member of small-animal mount assembly is arranged in the imaging region of scanhead unit.
Then, the fixed mount of scanning head assembly is positioned proximate procedure position on first track.In an example, along the first track slippage active block stop 50, and several centimetres of final procedure position of the expectation that is positioned at fixed mount with the expectation procedure position active block stop 50 is fixed on first track.Will be appreciated that the position that the control of the fixed mount by handling scanning head assembly can the accurate adjustment scanhead unit.The fixed mount of movable scan head assembly contacts with active block stop until it, like this desired image plane of scanhead unit be positioned so that the plane of delineation part of being studied on the toy is divided equally.
Will be appreciated that, when the imaging phase finishes, small-animal mount assembly and image-forming assembly can be removed (towards track end separately) from the procedure position on first and second tracks, keep the aligning and the relative position of small-animal mount assembly and image-forming assembly simultaneously.Therefore, the set plane of delineation and table surface plane can not change.The previous setting of dependence activity and/or fixed stop can be placed on new toy on the table member, and toy assembly and image-forming assembly can be reorientated.
If use the pin injecting assembly, then syringe part filled fluid to be injected.Then, the base component of pin injecting assembly is positioned proximate procedure position on the 3rd track.In an example, along the 3rd track slippage active block stop, and several centimetres of final procedure position of the expectation that is positioned at base component with the expectation procedure position active block stop is fixed on the 3rd track.Will be appreciated that the position of the pin that the control by handling the slide sub-component can the accurate adjustment injection member.The base component of pin injecting assembly is moved to it contacted and handled the slide sub-component with active block stop control, make pin be placed in the expectation pin plane, this expectation pin plane also can be the plane of delineation of set scanhead unit.Can also handle the slide sub-component in expectation pin plane, to select the expectation angle of penetration of pin.
Insert a needle in the insertion point of pin and to be studied in the toy to a desired depth, and manually or by utilizing piston control assembly injecting sample material.Generally speaking, when the tissue around the pin end has held extra volume, can on the screen of system, see the affirmation information of the injection mass such as fluid usually.Then, can extract pin out and finish operation.
Subsequently, can optionally pin injecting assembly, scanning head assembly and/or small-animal mount assembly be removed from their procedure position.New toy can be put on the table member of small-animal mount assembly, and can rely on before being provided with of movable/fixed stops that pin injecting assembly, scanning head assembly and/or small-animal mount assembly are reorientated.Will be appreciated that the plane of scanhead unit and the plane of syringe part will keep coplane.
Can be contemplated that and utilize imaging system 10 of the present invention can finish many other operations.The design of the multiple road of this imaging system make the operator can be in the imaging plane of the scanhead unit of scanning head assembly the pin of alignment pins injecting assembly accurately.Then, pin injecting assembly, small-animal mount assembly and scanning head assembly can come and go move along they tracks 32,34 and 36 separately, and can get back to their initial process position and do not lose coplanar aligned between the plane of delineation of the pin of the aligning of the plane of delineation or syringe part and scanhead unit.
It will be apparent to those skilled in the art that under situation about not departing from the scope of the present invention with spirit and can carry out various body and the modification of changing in the present invention.Consider description of the present invention disclosed herein and practice, other embodiments of the present invention will be readily apparent to persons skilled in the art.Purpose is that description and example are exemplary, and true scope of the present invention and spirit will be pointed out by following claim.
Claims (21)
1. imaging system that is used for the part imaging of toy comprises:
A plurality of elongated rails, described a plurality of elongated rails comprises first track and second track, each track has near-end, the far-end and the longitudinal axis of spacing is arranged, the near-end of first track is in contiguous first edge second track, between the second track near-end and far-end, and the longitudinal axis of first track becomes the certain angle between 150 ° to 30 ° with the longitudinal axis of second track;
Scanning head assembly with fixed mount, described fixed mount have to be installed on first track and to be constructed and arranged to and are suitable for the scanning head assembly base component that moves with linear bidirectional mode along the longitudinal axis of first track; With
The small-animal mount assembly comprises:
A. the workbench sub-component that has table member, described table member have end face and bottom surface and define table plane; And
B. stator assembly, described stator assembly comprises:
I. holder package base member, described holder package base member is installed on second track and is constructed and arranged to the longitudinal axis that is suitable for along second track and moves with linear bidirectional mode;
Ii. have upper surface and lower surface and define first of the longitudinal axis that is parallel to second track and perpendicular to first second surface platform, described platform also defines platform plane, and described platform plane is by first and second axis limit; With
Iii. be constructed and arranged to the platform adjustment mechanism that is suitable in described platform plane, moving described platform, described platform adjustment mechanism has platform base and adjustable armature, described platform base is connected to the part of the end face of described holder package base member, and described armature is connected to the part at the edge of described platform; And
Iv. be placed on the table orientation controlling organization on the part of upper surface of described surface platform, described table orientation controlling organization is constructed and arranged to the table plane that is suitable for regulating described table member, and wherein said directed controlling organization comprises: the die cavity with top and bottom; Be placed in the described die cavity and the magnetic padlock with movable magnet with part, described magnetic padlock can move to bonding station from withdrawal, unengaged position, attracts to touch the upper surface of described platform at described bonding station magnet.
2. imaging system according to claim 1, it is characterized in that, described a plurality of elongated rails comprises the 3rd track, the near-end of the 3rd track is in contiguous second edge second track, between the second track near-end and far-end, and the longitudinal axis of the 3rd track is basic coaxial with the longitudinal axis of first track.
3. imaging system according to claim 2, it is characterized in that, also comprise the pin injecting assembly, described pin injecting assembly comprises being installed on the 3rd track and being constructed and arranged to and is suitable for the injecting assembly base component that moves with linear bidirectional mode along the longitudinal axis of the 3rd track.
4. imaging system according to claim 1 is characterized in that described scanning head assembly also comprises the scanhead unit with operation issue end, and described scanhead unit is electrically connected to computer.
5. imaging system according to claim 4 is characterized in that, described fixed mount also comprises:
The stay of the elongation that is connected to and stretches out from described scanning head assembly base component, described stay have outer surface and are basically perpendicular to the longitudinal axis that described scanning head assembly base component extends;
Have first end and the cantilever beam that second end of spacing is arranged, described second end has shroud member, described shroud member is constructed and arranged to the outer surface that is suitable for along described stay and moves with linear bidirectional mode, and described shroud member has the beam locking mechanism that is used for described shroud member is fixed on the desired locations of described stay; With
Be connected to the scanhead unit orientation controlling organization of the part of the part of first end of described beam and described scanhead unit, described scanhead unit orientation controlling organization is constructed and arranged to the transmitting terminal that is suitable for described scanhead unit and is positioned in the desired image plane.
6. imaging system according to claim 1 is characterized in that, the lower surface of described platform covers and is placed on the end face of described holder package base member.
7. imaging system according to claim 6 is characterized in that, the upper surface and the lower surface of described platform scribble low-friction material.
8. imaging system according to claim 6 is characterized in that, the end face of described platform and described holder package base member is positioned at parallel plane.
9. imaging system according to claim 1 is characterized in that, described directed controlling organization comprises:
Be placed on the bearing in the described die cavity;
The vertical column component that engages with described bearing is so that can rotate described column component around vertical axes; With
Be constructed and arranged to and be suitable for the coarse height mechanism of described vertical column component along described vertical axes bidirectional-movement.
10. imaging system according to claim 9 is characterized in that, described directed controlling organization comprises:
The braking surface that is connected with described column component; With
Be constructed and arranged to the rotation control mechanism that is suitable for engaging described braking surface.
11. imaging system according to claim 10 is characterized in that, described directed controlling organization comprises:
The removable cover that is connected with the upper movable ground of described column component; With
Be constructed and arranged to and be suitable for described removable cover along the accurate adjustment elevation control mechanism therefor of described vertical axes with respect to the top bidirectional-movement of described column component.
12. imaging system according to claim 11 is characterized in that, described directed controlling organization comprises:
The first gradient controlling organization that is operably connected with the top of described removable cover, the described first gradient controlling organization has end face; With
The second gradient controlling organization that is operably connected with the end face of the first gradient controlling organization and is operably connected with the bottom surface of described table member,
Wherein the first gradient controlling organization is constructed and arranged to and is suitable for regulating and fixes the gradient of described table member with respect to the y axle of table plane, and wherein the second gradient controlling organization is constructed and arranged to and is suitable for regulating and fixes the gradient of described table member with respect to the x axle of table plane.
13. imaging system according to claim 1 is characterized in that, described workbench sub-component comprises:
Control device; With
At least one ECG control pad, described at least one ECG control is filled up on the end face that is attached to described table member and is electrically connected to described control device, and each ECG pad produces the ECG signal of the detection ECG that represents a part that is placed on the toy on this ECG pad and gives described control device.
14. imaging system according to claim 13 is characterized in that, described workbench sub-component also comprises:
Be placed at least one the electronic heating element grid on the end face of described table member.
15. imaging system according to claim 14, it is characterized in that, described workbench sub-component also comprises the thermocouple that is connected and is electrically connected to described control device with the end face of described table member, and described thermocouple produces representative and gives described control device near the temperature signal of the temperature at this thermocouple place.
16. imaging system according to claim 15, it is characterized in that, described workbench sub-component also comprises the rectal temperature probe that is electrically connected to described control device, and described rectal temperature probe produces the interior temperature signal of body of temperature in the detected petty action object of representative and gives described control device.
17. imaging system according to claim 1 is characterized in that, described workbench sub-component also comprises:
Dish with surrounding wall; With
Dish supporting mechanism with arm member and fastener, described arm member has the upper and lower, the top of described arm member is constructed and arranged on the part of the wall that is suitable for being clamped to described dish, the bottom of described arm member defines the groove of elongation, wherein, described fastener passes described groove and the part of the bottom of described arm member is fixed on the edge of described table member during use.
18. imaging system according to claim 1 is characterized in that, described workbench sub-component comprises:
Has the toy cover that definite shape and size match with the part with the snout of toy; With
Be fixed on the locking member on the part of end face of described table member, described locking member is constructed and arranged to a part that is suitable for firmly grasping described toy cover.
19. imaging system according to claim 3 is characterized in that, described pin injecting assembly also comprises:
The syringe sub-component, described syringe sub-component has syringe part, and described syringe part has the pin of elongation; With
With the slide sub-component that described pin injecting assembly base component is connected, described syringe part is connected with the part of described slide sub-component, and described slide sub-component is constructed and arranged to and is suitable for described pin is positioned in the pin plane of expectation.
20. imaging system according to claim 19, it is characterized in that, described pin injecting assembly comprises hinged armature assembly, wherein said hinged armature assembly comprises a plurality of cooperative arm members, described a plurality of cooperative arm members has the bearing that is connected with the end portion of described a plurality of cooperative arm members, described syringe part is operably mounted on the described bearing, and wherein said hinged armature assembly is constructed and arranged to the end that is suitable in the pin plane of described expectation around described pin and rotates described syringe part to making described pin have the angle of penetration of expectation with respect to vertical axes.
21. imaging system according to claim 20 is characterized in that, described syringe sub-component also comprises being constructed and arranged to and is suitable for controlling described syringe part and inserts mechanism with respect to the release of described bearing and the pin of drawing back.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41716702P | 2002-10-10 | 2002-10-10 | |
| US60/417,167 | 2002-10-10 | ||
| US60/417,185 | 2002-10-10 | ||
| US60/468,960 | 2003-05-09 | ||
| US60/468,959 | 2003-05-09 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910008725 Division CN101480346A (en) | 2002-10-10 | 2003-10-10 | Integrated multi-rail imaging system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1720000A CN1720000A (en) | 2006-01-11 |
| CN100475137C true CN100475137C (en) | 2009-04-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200380105066 Expired - Fee Related CN100475137C (en) | 2002-10-10 | 2003-10-10 | Integrated multi-rail imaging system |
| CN 200910008725 Pending CN101480346A (en) | 2002-10-10 | 2003-10-10 | Integrated multi-rail imaging system |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200910008725 Pending CN101480346A (en) | 2002-10-10 | 2003-10-10 | Integrated multi-rail imaging system |
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| Country | Link |
|---|---|
| CN (2) | CN100475137C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT106930A (en) * | 2013-05-03 | 2014-11-03 | Univ Trás Os Montes E Alto Douro | WORKING SURFACE WITH CONTROLLED HEATING AREA FOR BODY TEMPERATURE MAINTENANCE IN ANIMALS |
| WO2015110436A1 (en) * | 2014-01-27 | 2015-07-30 | Koninklijke Philips N.V. | An ultrasound imaging system and an ultrasound imaging method |
| CN105233372B (en) * | 2015-11-06 | 2018-10-23 | 南昌德漫多科技有限公司 | needleless injection system |
| CN109821104B (en) * | 2019-04-02 | 2021-04-16 | 南通大学附属医院 | Auxiliary positioning device for puncture of port seat of infusion |
| CN113633272A (en) * | 2021-07-05 | 2021-11-12 | 上海东软医疗科技有限公司 | Leveling assembly, adjusting device and medical imaging system |
-
2003
- 2003-10-10 CN CN 200380105066 patent/CN100475137C/en not_active Expired - Fee Related
- 2003-10-10 CN CN 200910008725 patent/CN101480346A/en active Pending
Also Published As
| Publication number | Publication date |
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| CN1720000A (en) | 2006-01-11 |
| CN101480346A (en) | 2009-07-15 |
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