CN100479739C - 构造生物传感器的方法 - Google Patents

构造生物传感器的方法 Download PDF

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Publication number
CN100479739C
CN100479739C CNB2004800276336A CN200480027633A CN100479739C CN 100479739 C CN100479739 C CN 100479739C CN B2004800276336 A CNB2004800276336 A CN B2004800276336A CN 200480027633 A CN200480027633 A CN 200480027633A CN 100479739 C CN100479739 C CN 100479739C
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projection
chemical activity
electro
film system
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CN1856270A (zh
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荣伦斯·B·詹森
肯尼思·W·沃德
埃伦·M·安德森
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Bayer Healthcare LLC
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Isense Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter

Abstract

构造分析物传感器(10)的方法。该方法开始于提供电化学活性表面(24)的步骤。然后，构造由介电材料制成并从电化学活性表面(24)横向向外伸出的至少一个凸起(22)。向电化学活性表面和凸起(22)涂敷可固化的液体，随后使其固化。在此过程中，可能是几个凸起(22)之一的凸起(22)用于在固化之前和固化期间托住所述液体。

Description

构造生物传感器的方法
技术领域
本发明总体上涉及皮肤分析物传感器的领域。
背景技术
在留置葡萄糖传感器的设计和制造中，在将随后固化的粘性液体层材料涂敷于电化学活性(铂)表面上的处理中遇到了问题。希望具有在大约平方毫米数量级的活性表面区域。不幸地，当将粘性液体浸涂到此相对大的区域上时，很难构造厚度足以对葡萄糖的存在产生足够响应的涂布。
发明内容
在第一独立方面中，本发明是一种具有活性传感区的留置分析物传感器。该传感区包括电化学活性表面和附着于该电化学活性表面的膜系统。此外，介电材料的至少一个凸起(nub)从电化学活性表面向外伸出并用作膜系统的支托结构。
在第二独立方面中，本发明是一种构造分析物传感器的方法。该方法开始于提供电化学活性表面的步骤。随后，构造由介电材料制成并从电化学活性表面横向向外伸出的至少一个凸起。向电化学活性表面涂敷可固化的液体，随后使其固化。在此过程中，所述凸起(可能是几个凸起中的一个)用于在固化之前和固化期间托住液体。
结合附图，考虑到下面对优选实施例的详细说明，将会更容易地理解本发明的前述和其他目的、特征和优点。
附图说明
图1是使用本发明的方法被形成为生物传感器的结构的一部分的工件的侧视图。
图2是由图1的工件构造的传感器的侧视图。
具体实施方式
在分析物(典型地为葡萄糖)传感器10的优选实施例中(图2)，用25微米厚的聚酰亚胺层14涂布178微米厚的铂丝12。将银丝16包绕层14的一部分。此外，不锈钢回缩引线(retractor lead)18形成传感器10的一部分。
通过激光削除聚酰亚胺层14来形成各自长2mm的三个凹部20，以形成工件8(图1)。凹部20之间的聚酰亚胺形成依托于聚酰亚胺14在丝12上的附着的一组环形片22。在此激光加工操作之后，可以用使得工件可以检测葡萄糖的材料24对该工件进行浸涂。典型地，材料24由一组通过一系列浸涂操作间以固化操作而构成的层组成。这些层典型地包括如美国专利5,165,407(通过引用将其并入于此，就像在此对其进行充分阐述一样)中所述的干扰物隔绝层、葡萄糖氧化酶层和选择性渗透层。各粘性液体的表面在片22之间趋向于形成有些像悬链线的形状。由此，与不存在片22的附着相比，附着了粘性液体的更大部分。该更大的厚度，特别是针对葡萄糖氧化酶层的更大厚度，对于产生对存在葡萄糖和氧气的健壮响应是很重要的。
工业应用性
本发明通常在生产和提供皮肤分析物传感器方面具有工业应用性。
以上说明书中采用的术语和表达用作描述性而非限制性的术语。使用这些术语和表达并无意将所图示和所描述的特征或者其部分的等同物排除在外，应该认识到本发明的范围仅由所附权利要求定义和限制。

Claims (19)

1、一种留置分析物传感器，包括：
电化学活性表面；
介电材料的至少一个凸起，其从所述电化学活性表面向外伸出；以及
附着于并基本覆盖所述电化学活性表面和所述凸起的膜系统。
2、根据权利要求1所述的传感器，其中，所述至少一个凸起为片的形式。
3、根据权利要求1所述的传感器，其中，所述电化学活性表面被限定为纵长体的一部分。
4、根据权利要求3所述的传感器，其中，所述纵长体的横截面为圆形。
5、根据权利要求1所述的传感器，其中，所述至少一个凸起包括环形片。
6、根据权利要求1所述的传感器，其中，所述至少一个凸起从所述电化学活性表面纵向地移位。
7、根据权利要求1所述的传感器，其中，所述膜系统包括多个膜。
8、根据权利要求1所述的传感器，其中，所述膜系统包括酶层。
9、根据权利要求1所述的传感器，其中，所述凸起包括几个凸起。
10、根据权利要求9所述的传感器，其中，所述电化学活性表面贯穿所述凸起。
11、根据权利要求9所述的传感器，其中，所述膜系统在所述凸起之间限定悬链线的表面。
12、根据权利要求1所述的传感器，其中，所述膜系统限定所述传感器的外表面。
13、根据权利要求1所述的传感器，其中，所述电化学活性表面包括铂。
14、根据权利要求1所述的传感器，其中，所述至少一个凸起包括聚酰亚胺。
15、根据权利要求8所述的传感器，其中，所述膜系统进一步包括选择性渗透层。
16、根据权利要求8所述的传感器，其中，所述膜系统进一步包括干扰物隔绝层。
17、根据权利要求1所述的传感器，其中，所述凸起包括四个凸起。
18、根据权利要求9所述的传感器，其中所述凸起包括四个凸起，并且所述四个凸起形成三个凹部。
19、根据权利要求1所述的传感器，其中所述膜系统仅附着于并基本覆盖所述电化学活性表面和所述凸起。
CNB2004800276336A 2003-08-14 2004-08-11 构造生物传感器的方法 Expired - Fee Related CN100479739C (zh)

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US10/640,980 US7529574B2 (en) 2003-08-14 2003-08-14 Method of constructing a biosensor
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WO2005018420A2 (en) 2005-03-03
EP1659933A4 (en) 2009-03-11
CN1856270A (zh) 2006-11-01
CA2535394A1 (en) 2005-03-03
US20050038330A1 (en) 2005-02-17
US7529574B2 (en) 2009-05-05
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JP4790612B2 (ja) 2011-10-12
CA2535394C (en) 2014-03-25

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