High strength supersonic wave treatment real-time monitoring system and method
Technical field
The present invention relates to a kind of system and method that high-intensity therapeutic ultrasound wave treatment process is monitored in real time, relate in particular to a kind of available B ultrasonic machine high-strength ultrasonic is carried out the noiseless system and method for monitoring in real time at therapeutic process.
Technical background
Treating with ultrasonic equipment is new developing technology in recent years, also needs to solve a lot of difficult problems in clinical practice, realizes one of difficult problem that the real-time monitoring of noiseless of therapeutic process will solve exactly with the B ultrasonic machine.The high strength supersonic wave treatment is that ultrasound wave is transmitted in the body from external, and focuses on treatment region in vivo, produces high temperature at treatment region, makes treatment region pathological tissues generation coagulation necrosis, thereby reaches the purpose of treatment disease.In therapeutic process, need point of care is implemented to monitor, whether safe and effective to guarantee treatment.Surveillance style can adopt MRI, CT, B ultrasonic machine etc., but it is also uneconomical that MRI is an inconvenience, the CT Looking Out Time is long, its ray is unfavorable to the patient, though the B ultrasonic machine can be avoided the defective of MRI and CT as the surveillance style of high strength supersonic wave treatment, the B ultrasonic machine also has its inherent shortcoming, and promptly the B ultrasonic machine is subjected to the hyperacoustic interference of the very high treatment of intensity easily, make image be difficult to identification, monitor to be difficult to accomplish in real time effectively.
Patent publish was once arranged, the B ultrasonic machine is done appropriate reconstruction and combine with ultrasonic therapy unit, interference in the area for treatment is removed, as U.S. Pat 6425867B1 promptly is like this, this Patent publish removes to control ultrasonic therapy unit with the scan-synchronized signal of B ultrasonic machine, near the treatment region interference fringe are removed, but the place that this patent is difficult to carry out is and need carries out inside transformation to the B ultrasonic machine, and muting zone only limit near the small range of point of care.It is present extremely unrealistic to transform the B ultrasonic machine, and this needs the permission and the technical support of B ultrasonic machine manufacturer.Simultaneously, the noiseless monitoring range is little, make troubles for clinical use, because the average transmit power of described noiseless monitor area of this patent and ultrasonic therapy unit interrelates, the noiseless monitor area is big more, the average acoustic emission power of therapy apparatus is more little, and this shortcoming especially is not suitable for the treatment of deep pathological tissues is monitored.
Summary of the invention
In order to overcome deficiency of the prior art, the object of the present invention is to provide a kind of high strength supersonic wave treatment system of monitoring in real time.This system needn't carry out inside transformation to the B ultrasonic machine, and can avoid the noise jamming of high-intensity therapeutic ultrasound ripple, to realize with the real time monitoring of B ultrasonic machine to the high strength supersonic wave treatment.
A further object of the present invention provides a kind of high strength supersonic wave treatment method of monitoring in real time.The transmitted pulse of this method employing clock-pulse generator and the output signal of B ultrasonic machine are synchronous, control the treatment time of ultrasonic therapy equipment and the signals collecting of Control Computer simultaneously, in treatment ultrasound wave intermittent time section, the interferential B ultrasonic machine of intercepting noiseless image.
Another purpose of the present invention is to adopt the high strength supersonic wave treatment system and method for monitoring in real time, and obtains the picture rich in detail that is not subjected to treat the interferential real-time B ultrasonic machine of ultrasound wave.This image can be clear and definite the positional information of learning ultrasonic therapy point.
In sum, high strength supersonic wave treatment real-time monitoring system provided by the invention and method, this system comprise clock-pulse generator, signal collecting device, B ultrasonic machine, ultrasonic therapy equipment, computer and display.This method is to utilize the intermittent time emission lock-out pulse of ultrasonic therapy, this pulse control ultrasonic therapy equipment is with mode emitting treatment ultrasound wave intermittently, simultaneously Control Computer receives the information of B ultrasonic machine in the intermittent time section again, again because the signal and the pulse signal of the output of B ultrasonic machine are synchronous, avoided simultaneously the interference of treatment ultrasonic hash again, so the B ultrasonic machine monitors that the location drawing picture of ultrasonic therapy point can clearly show by computer.This system and method is worked under unified coordination of lock-out pulse instruction, has realized that the noiseless in the high-strength ultrasonic therapeutic process is monitored in real time, and has obtained out B ultrasonic image clearly.
For reaching above-mentioned purpose, high strength supersonic wave treatment real-time monitoring system provided by the invention, the technological means of employing comprises ultrasonic therapy equipment and B ultrasonic machine, and simultaneously, this system also comprises:
One lock-out pulse generator, this clock-pulse generator link to each other with computer with ultrasonic therapy equipment respectively;
One signal collecting device, this signal collecting device link to each other with B ultrasonic machine, computer respectively;
One computer and display, this computer link to each other with clock-pulse generator, signal collecting device and display respectively;
To be divided into treatment time and intermittent time the working time, in treatment time, by ultrasonic therapy equipment emission ultrasonic therapy, in the intermittent time, ultrasonic therapy equipment quits work, and the B ultrasonic machine can receive the positional information at interference-free ultrasonic therapy position.
For reaching above-mentioned purpose, the present invention also provides a kind of high strength supersonic wave treatment real-time monitoring system, and this system comprises ultrasonic therapy equipment and B ultrasonic machine, and this system also comprises:
One lock-out pulse generator, this clock-pulse generator links to each other with ultrasonic therapy equipment;
One signal collecting device, this signal collecting device link to each other with B ultrasonic machine, computer respectively;
One computer and display, this computer is with signal collecting device, display link to each other respectively;
To be divided into treatment time and intermittent time the working time, in treatment time, by ultrasonic therapy equipment emission ultrasonic therapy, in the intermittent time, ultrasonic therapy equipment quits work, and the B ultrasonic machine can receive the positional information at interference-free ultrasonic therapy position.
The technical method that the present invention adopts is, in order to obtain the interference-free positional information of B ultrasonic machine, control hyperacoustic treatment time by clock-pulse generator, allow hyperacoustic treatment have an intermittent time, clock-pulse generator utilizes this intermittent time to send lock-out pulse, in more detail, after the instruction of clock-pulse generator emission lock-out pulse, before sending the lock-out pulse instruction next time, be divided into treatment time section T1 and intermittent time section T2 in this period T, in treatment time section T1 emission ultrasonic therapy, and treat hyperacoustic emission in this intermittent time of pulse command section T2 control that clock-pulse generator sends, because the signal of B ultrasonic machine output and the signal of pulse generator are synchronous, in the intermittent time section of control treatment ultrasonic emitting, the B ultrasonic machine can receive the positional information of interference-free hyperacoustic therapentic part.This information is sent in the signal collecting device, and the image signal transformation that the B ultrasonic machine is sent becomes to calculate the signal of function identification, and this signal is delivered to the location drawing picture that demonstrates the supervision of B ultrasonic machine in the display after the machine processing as calculated.Because computer is subjected to the control of clock-pulse generator, the information when only gathering the instruction of emission lock-out pulse, this information is again that B ultrasonic machine image is not treated interferential positional information.Therefore, the image of computer demonstration is point of care position clearly.
System and a method according to the invention, the B ultrasonic machine image that obtains the real-time monitoring of noiseless as can be seen is the method that digital image processing techniques are combined with ultrasonic therapy unit, promptly adopt the output signal and the synchronous method of synchronization pulse of B ultrasonic machine, create the real-time B ultrasonic machine image that does not have noise jamming fully, make therapeutic process high-visible, and do not need the B ultrasonic machine is transformed, the mode of enforcement is not only simple and convenient but also effectual, has the good actual application effect simultaneously again.
Below with the specific embodiment the present invention is done to describe in detail with reference to the accompanying drawings.
Description of drawings
Fig. 1 is that embodiments of the invention 1 monitoring system constitutes block diagram.
Fig. 2 is instruction of emission lock-out pulse and the ultrasonic corresponding diagram that involves the image acquisition time of treatment.
Fig. 3 is for being subjected to treating the interferential B ultrasonic machine of ultrasound wave image.
The B ultrasonic machine image of Fig. 4 for implementing to gather behind the present invention.
Fig. 5 is that embodiments of the invention 2 monitoring systems constitute block diagram.
Symbol description among the figure
1 clock-pulse generator
2 ultrasonic therapy equipments
3 B ultrasonic machines
4 signal collecting devices
5 computers
6 display
The necessary connection of 7 ultrasonic therapy equipments and B ultrasonic machine
8 lock-out pulses
9 ultrasound wave interfering pictures
10 ultrasound wave are interfering picture not
11 treatment ultrasound wave
The identification of 14 signals
15 refreshing instructions
The specific embodiment
Embodiment 1: as shown in Figure 1, involved in the present invention uses the B ultrasonic machine to the real-time noiseless monitoring system of high-strength ultrasonic therapeutic process, and it comprises: clock-pulse generator 1, ultrasonic therapy equipment 2, B ultrasonic machine 3, signal collecting device 4, computer 5 and display 6.Clock-pulse generator 1 links to each other with computer 5 with ultrasonic therapeutic apparatus 2 respectively, and B ultrasonic machine 3 links to each other with signal collecting device 4, and signal collecting device 4 links to each other with computer 5, and computer 5 links to each other with display 6 with clock-pulse generator 1.Do not relate to the transformation to existing equipments such as B ultrasonic machine 3, computers 5 in this system, clock-pulse generator 1 can work independently.
As shown in Figure 1, the video output signals of B ultrasonic machine 3 or RGB output signal are directly delivered in the signal collecting device 4, the signal that the image signal transformation that signal collecting device 4 is sent B ultrasonic machine 3 becomes computer 5 to discern, this signal are delivered to the figure that demonstrates B ultrasonic machine 3 in the display 6 after machine 5 is handled as calculated.Simultaneous computer 5 receives the lock-out pulse instruction of being sent by clock-pulse generator 1, and the interference-free positional information of B ultrasonic machine image is carried in the lock-out pulse instruction.
The synchronization pulse that clock-pulse generator 1 sends is except that delivering to computer 5, also to give ultrasonic therapy equipment 2, ultrasonic therapy equipment 2 is after clock-pulse generator 1 emission lock-out pulse instruction 8, before sending the lock-out pulse instruction next time, be divided into treatment time section T1 and intermittent time section T2 in this period T, at treatment time section T1 emitting treatment ultrasound wave, and treat hyperacoustic emission in this intermittent time of pulse command section T2 control that clock-pulse generator sends, because the signal of B ultrasonic machine 3 outputs and the signal of pulse generator 1 are synchronous, in the intermittent time T2 of control treatment ultrasonic emitting, B ultrasonic machine 3 can receive the positional information 10 of interference-free hyperacoustic therapentic part.This information is sent in the signal collecting device 4, and the image signal transformation that B ultrasonic machine 3 is sent becomes to calculate the signal of function identification, and this signal is delivered to after machine is handled as calculated and demonstrated the location drawing that the B ultrasonic machine monitors in the display as 10.The necessary connection of dotted line 7 expression ultrasonic therapy equipments 2 and B ultrasonic machine 3 in Fig. 1, as long as monitor the ultrasonic therapeutic process with B ultrasonic machine 3, ultrasound probe will inevitably be accepted ultrasonic therapy equipment 2 ultrasonic waves transmitted.
As shown in Figure 2, this system and method thereof are to work under unified coordination of clock-pulse generator 1, and Fig. 2 demonstrates the not corresponding time relationship of interfering picture 10 and treatment ultrasound wave 11 of lock-out pulse 8 and B ultrasonic machine 3 ultrasound wave interfering pictures 9, ultrasound wave.Lock-out pulse section T 8 launch time
2With ultrasound wave interfering picture 10 shared time period T not
2And ultrasound wave intermittent time section T
2Be one to one; Lock-out pulse 8 dwell time section T
1With ultrasound wave interfering picture 9 shared time period T
1, 11 time period of ultrasonic therapy T
1Be one to one.Clock cycle T that clock-pulse generator 1 is produced and B ultrasonic machine cycle of images T, ultrasonic therapy period T are one to one.
As can be seen from Figure 2, the hyperacoustic dwell time section T of image 10 expression treatments of B ultrasonic machine 3
2Be interference-free, the image 9 expression treatment ultrasonic emitting time period T1 of B ultrasonic machine 3 are treated hyperacoustic interference, ultrasound wave not interfering picture 10 repeats by the period T of pulse instruction, and computer 5 sends 8 this time period of lock-out pulse T at clock-pulse generator 1
2B ultrasonic machine 3 is carried out signals collecting, send refreshing instruction to display 6 simultaneously, both can on display 6, obtain not interfering picture 10 of ultrasound wave.
In the system and method thereof involved in the present invention, the period T of pulse command 8 is 10ms~200ms, the ultrasonic therapy time T
1Be 5ms~180ms.
Fig. 3 represents that the image of B ultrasonic machine treated the interferential situation of ultrasound wave, this image is a sector image, this computer-chronograph 5 acquired signal in whole period T, the treatment position point that the B ultrasonic machine monitors is all covered by the interferential image 9 of ultrasound wave, because B ultrasonic machine 3 rate of scanning are too fast, so human eye can't be told not interfering picture 10 of ultrasound wave, what see is ultrasound wave interfering picture 9 among the figure, is a fan sweeping figure.Therefore, can not find point of care clearly in this image.
Fig. 4 is the B ultrasonic machine image 10 behind enforcement the present invention, and computer 5 is only at treatment ultrasound wave intermittent time section T
2Interior acquired signal is so demonstrate not interfering picture 10 of ultrasound wave on the display 6.Fig. 4 is for after implementing the present invention, interference-free image example, this image is finished on JC type high-intensity focus supersonic tumor therapy system, and it shows that the B ultrasonic machine image of demonstration is not subjected to treating hyperacoustic interference, and the positional information of point of care can show clearly.
Embodiment 2: Fig. 5 is another connected mode of system of the present invention, and this system comprises ultrasonic therapy equipment and B ultrasonic machine, and simultaneously, this system also comprises:
One lock-out pulse generator, this clock-pulse generator links to each other with ultrasonic therapy equipment;
One signal collecting device, this signal collecting device link to each other with B ultrasonic machine, computer respectively;
One computer and display, this computer is with signal collecting device, display link to each other respectively.
As can be seen, clock-pulse generator only connects ultrasonic therapy equipment from the foregoing description, its control treatment ultrasonic equipment 2.Computer only connects the signal collecting device and the display of B ultrasonic machine, computer 5 can independently be judged the interference-free position of B ultrasonic machine image, from the image of per second 30 frames, find out and be subjected to interferential image, with 10 reorganization of remaining undisturbed image and be presented on the display, make the observer only see undisturbed B ultrasonic image 10.The signal identification 14 of computer and the formation of refreshing instruction 15 all need not add hardware, can finish by simple programming.Because this programming does not belong to the scope of the present patent application, so no longer set forth.