CN100551545C - A kind of Centrifuge Cup that constitutes by a plurality of relatively independent separation chambers - Google Patents
A kind of Centrifuge Cup that constitutes by a plurality of relatively independent separation chambers Download PDFInfo
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- CN100551545C CN100551545C CNB2004101000490A CN200410100049A CN100551545C CN 100551545 C CN100551545 C CN 100551545C CN B2004101000490 A CNB2004101000490 A CN B2004101000490A CN 200410100049 A CN200410100049 A CN 200410100049A CN 100551545 C CN100551545 C CN 100551545C
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- centrifuge cup
- centrifuge
- isolated gate
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Abstract
A kind of Centrifuge Cup, it comprises cup (1), blood/cleaning solution inlet (2), conduit (3), decelerating ring (4), cleaning solution outlet (5), and it is characterized in that radially provides a plurality of isolated gates so that cup (1) is divided into a plurality of relatively independent separation chambers along cup (1).
Description
Technical field
The present invention relates to a kind of Centrifuge Cup.The invention still further relates to a kind of application centrifugal principle separating bio material, as the separation method of blood cell and blood plasma.
Background technology
Plasma exchange is described among the US4086924.With whole blood with transfer to Centrifuge Cup after anti-coagulants mixes, thereby separation of whole blood is become blood plasma and non-plasma fraction.Centrifuge Cup is the device that utilizes centrifugal principle that material is separated, its common purpose is to make the effect lower leaf of material to be separated in high speed centrifugation power, thereby reach separation, see United States Patent (USP): US4,983,158 and US4300717 number, Chinese utility model patent ZL99255623.6, it introduces the application as a reference.These three pieces of patent documents are incorporated herein by reference in full.
Figure one is a kind of schematic diagram of the Centrifuge Cup of present extensive use, and it comprises cup 1, blood/cleaning solution inlet 2, conduit 3, decelerating ring 4, cleaning solution outlet 5.Its operation principle is as follows: cup 1 runs up at the material that drives wherein down that runs up, material is in the action of centrifugal force lower leaf, cleaning solution enters the Centrifuge Cup bottom from mouthful static conduit 3 of 2 processes, the cleaning solution outside-in flows and passes outer material under action of centrifugal force, thereby reach the purpose of washing, the static decelerating ring 4 of passing through on cleaning solution continues slows down, and flows out from cleaning solution outlet 5.In Fig. 1, arrow is the route that blood and washing lotion enter separated region
Figure two is that another kind of form is centrifugal, and its basic principle is identical with the basic principle of figure one, though can realize more at an easy rate on the engineering, the effect of washing can be not fine.Space in Fig. 2 between cup 1 and the inner bag is between effective Disengagement zone.
All there is the defective of the following aspects in the Centrifuge Cup of two kinds of forms shown in figure one and the figure two:
1. minute blood cell there is certain destruction, this destruction is because of the reason of several aspects, the one, need frictionally to drive cup interior liquid acceleration or deceleration in rotation and the stopped process, and relative motion that exists between cell and the wall of cup and frictional force can cause cell impaired, in this case, the coarse more destruction in wall of cup surface is also serious more, and the 2nd, increased the touch opportunity of cell and inorganic matter, and biological ubiquitous incompatibility can cause the impaired of cell;
2. the effect of Fen Liing is undesirable, because when starting and stopping, there is relative motion between wall of cup and the blood cell, this relative motion meeting causes that the aspect between blood cell and blood plasma is disturbed in moderating process, thereby make separation destroyed fully, existing Centrifuge Cup hematocrit (ratio of blood cell and liquid in the liquid) when separating blood is up to the volume ratio about 60%, if the separation of various kinds of cell or multiple material will fundamentally miss one's aim
3. need a minimum through the blood of washing as reaching certain hematocrit (hematocrit is a blood cell and the ratio of botal blood volume), if also promptly the minimum of blood do not reach glassful, will not reach requirement through the hematocrit of the blood of washing
4. it is bigger to reach the used washing lotion amount of certain clean rate, generally reaches 1: 4, and this is that often having runner of one's own has influenced clean result because washing lotion can not be washed blood cell effectively
Since the liquid in the Centrifuge Cup can be in cup motion freely cause the unstability of system, under certain centrifugal rotational speed, centrifugation systems can produce vibration, sometimes even have a bigger destructiveness.
Therefore, need improve, to overcome at least a above-mentioned shortcoming to Centrifuge Cup of the prior art.
Therefore, one of purpose of the present invention provides a kind of improved Centrifuge Cup that overcomes above-mentioned at least a shortcoming.
Another object of the present invention provides a kind of biological substance, as the separation method of blood cell and blood plasma.
Summary of the invention
In order to solve problem one of above-mentioned in the prior art, find that through inventor herein's deep experiment Centrifuge Cup is through producing good clean result after the cup Disengagement zone installs isolated gate additional.
Specifically, the invention provides a kind of Centrifuge Cup, it comprises the static cup cover 6 that the cup 1 of rotation links to each other with cup 1 sealing; Cup 1 is made of outer wall 10 and bottom 13, has the enclosed cavity 14 that inner bag inwall 12 and inner bladder outer wall 11 constitute in cup 1, thereby constitutes Disengagement zone 15 between outer wall 10 and inner bladder outer wall 11; Static cup cover 6 has inlet 2, thereby in cup 1, introduce blood and/or cleaning solution to be washed with inlet 2 longitudinal ducts that communicate 3, passage 16 that will form and the outlet 5 that is connected with passage 16 through the decelerating ring 4 that the blood and/or the cleaning solution of washing are discharged cup 1; On cup 1 basic longitudinal direction, be divided into a plurality of relatively independent separation chambers 18 with Disengagement zone 15 with cup 1 along a plurality of isolated gates 17 of radially providing of cup 1.
The present invention also provides a kind of separation method that utilizes Centrifuge Cup to carry out blood cell and blood plasma, wherein Centrifuge Cup comprises cup 1, blood/cleaning solution inlet 2, conduit 3, decelerating ring 4, cleaning solution outlet 5, on cup 1 basic longitudinal direction, along cup 1 radially provide a plurality of isolated gates cup 1 is divided into a plurality of relatively independent separation chambers, this method may further comprise the steps:
Blood is entered cup 1 through blood/cleaning solution inlet 2 and conduit 3;
Cleaning solution autoblood/cleaning solution inlet 2 and conduit 3 are imported cup, and the cleaning solution outside-in flows and passes blood cell layer and plasma layer under action of centrifugal force, thereby washs;
The static decelerating ring 4 of passing through on cleaning solution continues slows down, and flows out from cleaning solution outlet 5.
Description of drawings
Fig. 1 is the schematic diagram of the Centrifuge Cup of prior art.
Fig. 2 is the schematic diagram of another kind of scheme of the Centrifuge Cup of prior art.
Fig. 3 is a kind of embodiment schematic diagram of Centrifuge Cup of the present invention, and wherein Fig. 3 .2 is the cross sections figure of Centrifuge Cup.
Fig. 4 is the schematic diagram of the another embodiment of Centrifuge Cup of the present invention.
Fig. 5 is the another embodiment schematic diagram of Centrifuge Cup of the present invention.
Fig. 6 is the another embodiment schematic diagram of Centrifuge Cup of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, with blood cell and blood plasma be separated into the example the present invention is described in detail.But the present invention is not limited to the embodiment of following detailed description.
Centrifuge Cup schematic diagram of the present invention such as Fig. 3-6.
Referring to accompanying drawing 3, the invention provides a kind of Centrifuge Cup, it comprises the static cup cover 6 that the cup 1 of rotation links to each other with cup 1 sealing; Cup 1 is made of outer wall 10 and bottom 13, has the enclosed cavity 14 that inner bag inwall and inner bladder outer wall constitute in cup 1, thereby constitutes Disengagement zone 15 between outer wall 10 and inner bladder outer wall 11; Static cup cover 6 has inlet 2, thereby in cup 1, introduce blood and/or cleaning solution to be washed with inlet 2 longitudinal ducts that communicate 3, passage 16 that will form and the outlet 5 that is connected with passage 16 through the decelerating ring 4 that the blood and/or the cleaning solution of washing are discharged cup 1; On cup 1 basic longitudinal direction, be divided into a plurality of relatively independent separation chambers 18 with Disengagement zone 15 with cup 1 along a plurality of isolated gates 17 of radially providing of cup 1.
Referring to accompanying drawing 3, the cup cover 6 of Centrifuge Cup of the present invention comprises many feed pipes and seal, and the feed pipe of Centrifuge Cup and the concrete structure of seal be at US4, detailed description is arranged in 983,158.Specifically, cup single 6 has friction plate 21 and 22, rubber support 23 up and down and is used to protect the helmet 24 of rubber and rubbing surface.Inlet 2 on the cup cover 6 (also being referred to as blood/cleaning solution inlet 2) leads to feed pipe 3 (also being referred to as conduit 3) longitudinally, and blood and/or cleaning solution enter the bottom of cup 1 through conduit 3.
Fig. 3 .2 is along the cross sections figure with the Centrifuge Cup at isolated gate 17 places.
The cup 1 of rotation and cup 1 sealing.The mode of its sealing can be the mode that is usually used in Centrifuge Cup in the prior art, sees US4300717 and ZL99255623.6
Isolated gate 17 of the present invention has been divided into independent separate interval 18 one by one with separate areas in the Centrifuge Cup 15, this fundamentally avoided Centrifuge Cup quicken and moderating process in blood cell with respect to wall of cup, supernatant with respect to the relative motion between the blood cell, thereby separate blood can not mixed again.
Centrifuge Cup of the present invention can be used for the separation of material under rotating at a high speed, and the separation of the separation of multiple material, especially blood, as separation of red blood cells, blood platelet or other blood component.Referring to US4,983,158 and US4300717 number, Chinese utility model patent ZL 99255623.6.
The operation of the Centrifuge Cup of Fig. 3 is as follows:
Pending blood is entered the bottom of Centrifuge Cup through conduit 3 by inlet 2; Thereby starting the power supply (not shown) makes the rotation of Centrifuge Cup cup make pending blood enter Disengagement zone 15 and layering under action of centrifugal force; Again cleaning solution is entered the Centrifuge Cup bottom from mouthful static conduit 3 of 2 processes at this moment, cleaning solution enters each separation chamber 18 of Disengagement zone 15 under action of centrifugal force, and outside-in is mobile and pass outer material, thereby reaches the purpose of washing; Along with the adding of cleaning solution, the related material that is cleaned is assembled to the Centrifuge Cup center, and slows down when running into decelerating ring 4 by slit 16 via outlet 5 discharges.
Centrifuge Cup of the present invention, isolated gate can be divided into Centrifuge Cup several regions regularly also can be divided into several regions with Centrifuge Cup brokenly.
Centrifuge Cup of the present invention, isolated gate can be perpendicular to the inwall or the outer walls of Centrifuge Cup, but also can put to out of plumb.
Centrifuge Cup of the present invention, the plane of isolated gate can with the shaft parallel of Centrifuge Cup, but also can be not parallel.
Centrifuge Cup of the present invention, isolated gate can rise in the shape of a spiral, also can the undulate shape, described spirality can be to be clockwise rising, but also can be counterclockwise rising.Isolated gate is tilting, make it rise in the shape of a spiral, can make washing lotion and blood that the exchange process of abundant length is arranged like this, thereby reach the purpose that rate is cleaned in raising in some occasion.
Centrifuge Cup of the present invention can add hole or seam that some have a mind to reservation on isolated gate, or installs some holes or seam additional for the purpose of engineering.
Centrifuge Cup of the present invention, default communication passage can utilize law of connected vessels to reach desirable clean result like this on the certain altitude of isolated gate.
Centrifuge Cup of the present invention has a bottom isolated gate corresponding with described isolated gate in its bottom, can advance, reduce during blood back the relative motion of blood with respect to the Centrifuge Cup bottom like this.
Centrifuge Cup of the present invention in each the relatively independent isolated gate intercommunication of the lower edge of cup part, can guarantee like this when centrifugal in each relatively independent separated region that liquid and blood cell liquid level keep balance.
Centrifuge Cup of the present invention can be intercommunication at the upper limit position place of cup top blood cell or each relatively independent separation chamber, position of going up slightly again, can guarantee like this when centrifugal in each relatively independent separated region that liquid and blood cell liquid level keep balance.
Centrifuge Cup of the present invention, its inner bag can be to be made with having certain flexible material, can realize better closure like this.
Centrifuge Cup of the present invention, its isolated gate can be to be made with having certain flexible material, can realize better closure like this.
Centrifuge Cup of the present invention, its inner bag of described Centrifuge Cup and outer courage (outer wall 10) can be uneven, and be big up and small down as inside and outside courage spacing, otherwise or be big down little, and also correspondence with it of described isolated gate.
Centrifuge Cup of the present invention, described Centrifuge Cup profile can be bell, but also can be directly barrel-shaped.
Centrifuge Cup of the present invention, it is used to separate blood platelet or other blood component.
Centrifuge Cup of the present invention can utilize the variation of centrifugal speed to reach the effect of specific washing when separating.
Centrifuge Cup of the present invention can utilize the velocity variations of feed liquor to reach specific clean result when separating, as form the well-regulated motion of liquid in each separation chamber.
Centrifuge Cup of the present invention, isolated gate with inner bag or outside the contacted position of courage can adopt docking modes such as adding groove, bifurcated, overlap joint to reach preferable closure.
Centrifuge Cup of the present invention, the incisura when isolated gate being cut on its differing heights perpendicular to the plane of rotating shaft can and inconsistent, also be isolated gate can distortion between inner bag and the outer courage storing.
Centrifuge Cup of the present invention, its isolated gate can be interrupted storing, and blood plasma and blood cell are moved by predetermined purpose.
Centrifuge Cup of the present invention, sufficient space is reserved in its bottom, and blood cell when blood cell is assembled, can attach washing lotion at this space clustering in the time of can making stall or slow-speed, attaches Centrifuge Cup to be rotated after a certain amount of at a high speed, can improve clean rate with this.
Centrifuge Cup of the present invention, its bottom isolates mutually, but also can get around regulations mutually.
So the Centrifuge Cup of design can be realized the washing to material, and is widely used in separating of blood cell and blood plasma.Described Centrifuge Cup can be used for the separation of material under rotation at a high speed, and the separation of the separation of multiple material, especially blood, as separation of red blood cells, blood platelet or other blood component but application of the present invention obviously can have wider applicable object.
Because the acceleration of liquid no longer relies on frictional force with deceleration in Centrifuge Cup of the present invention, but directly act on by isolated gate, therefore not only avoided by friction and relative motion and cause blood cell is destroyed, and will make slow down and accelerator in the interface of blood cell and supernatant disturbance can not appear, just making the interface between supernatant and the blood cell remain original released state under the control a little, when the Centrifuge Cup stall, reclaim and directly to obtain the blood of high hematocrit.
Isolated gate only exists in the subregion in Centrifuge Cup, each described independently Disengagement zone will communicate with each other in the subregion, like this under the specified conditions in the whole operation process of Centrifuge Cup, according to law of connected vessels the interface of blood interface, blood cell and supernatant in each independent separate district will be consistent, this reclaims (as reclaiming rich platelet blood) for layering and the recovery of high pressure hematocele liquid is necessary.
If adopt the water intake mode of pulsating in the process of washing, new-type Centrifuge Cup more is difficult for making the blood layer to be damaged and disturbance than the Centrifuge Cup of classics, therefore has better clean result.
The quantity of the isolated gate that the present invention is used can be one or more, overlapping with the central shaft of Centrifuge Cup of its plane of described isolated gate along long face, that is isolated gate always points to the axle center on perpendicular to the tangent plane of axle, each isolation Disengagement zone, the position of certain altitude links to each other again in the top, and each isolation Disengagement zone also links to each other on the certain position of lower end.That Fig. 3 and Fig. 4 provide respectively is the embodiment that has added 6 and 20 isolated gates.That Fig. 5 and Fig. 6 provide respectively is the embodiment that has added 20 isolated gates and 6 isolated gates.
Also can place some isolated gates at the Centrifuge Cup that is used for sampled plasma, the benefit that this patent can bring equally also is applicable to this, and that figure five provides is an embodiment.
Make isolated gate and wall of cup be different angles and place, thereby can reach different washing purposes, also can make to be easier on the engineering realize.
If described isolated gate is also not exclusively isolated, the inwall or the outer wall that also are isolated gate and Centrifuge Cup have a suitably gap of size, promptly can realize so under suitable condition and isolate identical isolation effect fully, or partly reach the effect of isolation, thereby can reach special washing purpose.
Estimate the standard of Centrifuge Cup
When estimating washed blood, the standard of Centrifuge Cup part has following several:
I. minimum output blood flow volume, through the canonical form centrifugation, its glass capacity promptly is minimum output blood flow volume to existing;
Ii. the Centrifuge Cup rate of recovery, the haemocyte of recovery and flow into ratio between the haemocyte total amount;
Iii. the hematocrit of output blood;
Iv. to the destructiveness of blood cell, the destructiveness that blood cell is produced through the Centrifuge Cup effect, generally with the variation of free hemoglobin in a certain amount of blood before and after the rotation as index;
V. clean rate, after certain washing lotion amount washing, the ratio of this material total amount before the specific material that is washed is removed total amount and washed;
Vi. blood platelet retention rate, hematoblastic retention rate in the blood before and after washing;
Vii. fatty clearance, the clearance of fat in the blood before and after washing;
Viii. when the Centrifuge Cup slow-speed of revolution, can make under the effect of blood cell at gravity and assemble, can reach the purpose that improves the rate of cleaning thereby water inlet this moment can reach the purpose of more fully washing in the bottom;
Ix. the bottom is strengthened the space of storing up blood and can be made full use of the benefit that the x item brings;
X. when blood back, can be scheduled to the blood back hematocrit, such as from 40-90% can, when adopting three pumps to control into blood, blood back respectively, can utilize when advancing washing lotion and sneak into washing lotion when into lotion pumps reaches at blood back, can further improve clean rate like this.
Obviously, need fatty clearance, blood platelet retention rate, the rate of recovery in actual applications, clean rate, to clean blood pressure long-pending high more good more, destructive the smaller the better to blood cell, minimum output blood flow volume is the smaller the better.
The present invention has following at least a benefit:
(1) the blood cell hematocrit can improve, because the effect of isolated gate makes the interface of blood cell and supernatant liquid not disturbed Move, therefore can obtain the blood of high hematocrit;
(2) can adopt pulsating to wash blood, advance blood institute secondary band because the effect of isolated gate can reduce pulsating Therefore the disturbance to the interface that comes also can be adopted pulsating to advance blood and reach special washing purpose;
(3) can reduce destruction to blood cell, the existence of isolated gate make between blood cell and the wall of cup relative motion with Friction reduces greatly, and therefore the destruction to blood cell can reduce greatly;
(4) be conducive to reclaim rich platelet blood, because the interface of the effect different components of isolated gate can keep, Therefore, can be recovered under suitable condition rich platelet blood;
(5) minimum treating capacity can reach very little, because the interface of blood cell and supernatant liquid kept, so can So that minimum treating capacity reduces greatly, no longer reclaim when in detecting the blood back pipe, becoming supernatant liquid, So just can reach and reduce the minimum purpose of processing the blood amount. The mode of original centrifugal cup need to have children cup with Be suitable for the little characteristics of blood of children amount, but can accomplish that under new centrifugal cup mode a kind of centrifugal cup is suitable for each Plant occasion;
(6) can carry high-detergency, last processing can be adopted dense blood to add physiological saline and return to the blood bag together Thereby the water rate of the blood unit of making blood amount descends, and also namely can allow two pumps turn to together, and one is returned concentrated blood one The individual reason salt solution of bringing back to life can make like this and clean rate and further improve, even can only concentrate namely to clean and (manage The dense blood of opinion upper 100% adds that physiological saline namely can reach pure);
(7) thus can add and join different programs and can wash different contents because the effect of isolated gate, blood The interface of ball and supernatant liquid can keep substantially in good condition, therefore can reach with different pulsatile blood flows different The washing purpose, utilize different pulsation current can accomplish to a certain extent to remove or keep some blood The purpose of composition;
(8) Centrifuge Cup can suddenly stop or carry out work with very big acceleration, and can blood not produced because of friction generation disturbance and destruction;
(9) after adding isolated gate, help reducing the destabilizing factor of centrifuge, thereby the chance that occurs covibration in the rotation process can reduce greatly also.
Claims (8)
1. Centrifuge Cup, it comprises cup (1), blood and/or cleaning solution inlet (2), conduit (3), decelerating ring (4), cleaning solution outlet (5), it is characterized in that at cup (1) substantially longitudinally on the direction, radially provide a plurality of isolated gates so that cup (1) is divided into a plurality of relatively independent separation chambers along cup (1), wherein on the certain altitude of isolated gate, preset communication passage, so that relatively independent separation chamber is interconnected.
2. by the described Centrifuge Cup of claim 1, wherein isolated gate is divided into several regions with Centrifuge Cup cup (1) basically regularly, perhaps brokenly Centrifuge Cup cup (1) is divided into several regions.
3. by the described Centrifuge Cup of claim 1, wherein isolated gate is substantially perpendicular to the inwall or the outer wall of Centrifuge Cup cup (1), and is perhaps angled with the vertical direction of inwall or outer wall.
4. by the described Centrifuge Cup of claim 1, wherein the rotating shaft of the plane of isolated gate and Centrifuge Cup is substantially parallel, or with the rotating shaft of Centrifuge Cup at angle.
5. by the described Centrifuge Cup of claim 1, isolated gate raised shape or undulate shape in the shape of a spiral wherein be to rise clockwise or rising counterclockwise when raised shape in the shape of a spiral.
6. by the described Centrifuge Cup of claim 1, wherein the bottom isolated gate corresponding with described isolated gate arranged, be used for advancing, reducing during blood back the relative motion of blood with respect to the Centrifuge Cup bottom in its bottom.
7. a method of separating blood platelet or other blood component from blood is characterized in that using each described Centrifuge Cup of claim 1-6.
8. a method of gathering rich platelet blood is characterized in that using each described Centrifuge Cup of claim 1-6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101000490A CN100551545C (en) | 2004-12-07 | 2004-12-07 | A kind of Centrifuge Cup that constitutes by a plurality of relatively independent separation chambers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004101000490A CN100551545C (en) | 2004-12-07 | 2004-12-07 | A kind of Centrifuge Cup that constitutes by a plurality of relatively independent separation chambers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1785530A CN1785530A (en) | 2006-06-14 |
| CN100551545C true CN100551545C (en) | 2009-10-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004101000490A Expired - Fee Related CN100551545C (en) | 2004-12-07 | 2004-12-07 | A kind of Centrifuge Cup that constitutes by a plurality of relatively independent separation chambers |
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| CN (1) | CN100551545C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008006237A1 (en) * | 2006-06-13 | 2008-01-17 | Xiaojin Wang | Centrifugal cup consisting of multiple relatively independent separation chambe |
| CN100546725C (en) * | 2007-09-21 | 2009-10-07 | 翟周宣 | A kind of high speed bag type centrifugal device |
| WO2012060848A1 (en) | 2010-11-05 | 2012-05-10 | Haemonetics Corporation | System and method for automated platelet wash |
| CN108940614B (en) * | 2018-06-25 | 2021-02-09 | 江苏大洋环保工程有限公司 | Centrifugal separation drum rotating machine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| US4983158A (en) * | 1986-07-22 | 1991-01-08 | Haemonetics Corporation | Plasmapheresis centrifuge bowl |
-
2004
- 2004-12-07 CN CNB2004101000490A patent/CN100551545C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4300717A (en) * | 1979-04-02 | 1981-11-17 | Haemonetics Corporation | Rotary centrifuge seal |
| US4983158A (en) * | 1986-07-22 | 1991-01-08 | Haemonetics Corporation | Plasmapheresis centrifuge bowl |
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| CN1785530A (en) | 2006-06-14 |
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Assignee: Xijing Medical Articles Co Ltd, Xi'an Assignor: Beijing Hengzhong Technology Co., Ltd. Contract record no.: 2012610000071 Denomination of invention: Ceitrifugal cup constructed of multiple relatively indepundent separation chambers Granted publication date: 20091021 License type: Exclusive License Open date: 20060614 Record date: 20120528 |
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Granted publication date: 20091021 Termination date: 20151207 |