CN100591289C - Self-inflating air bag in digestive tract cavity - Google Patents
Self-inflating air bag in digestive tract cavity Download PDFInfo
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- CN100591289C CN100591289C CN200810300628A CN200810300628A CN100591289C CN 100591289 C CN100591289 C CN 100591289C CN 200810300628 A CN200810300628 A CN 200810300628A CN 200810300628 A CN200810300628 A CN 200810300628A CN 100591289 C CN100591289 C CN 100591289C
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Abstract
The invention discloses a self-inflating gasbag in a gastric lumen, which belongs to the technology field of medical and health instruments. The self-inflating gasbag comprises a sealed gasbag body filled inside with two gas-producing compounds that react to each other after being mixed to produce a gas, and a gastric-dissolved material packing the gasbag body form the outside thereof, wherein thetwo gas-producing compounds are insolated in different spaces inside the packed gasbag body. Compared with the prior intragastic water gasbag, the self-inflating gasbag has the advantages of simple use, easy placement, high level of comfort, function of inducing a feel of satiety, high safety and no risk to induce constipation, and the gasbag does not need to be placed or taken out through an operation.
Description
Technical field
The present invention relates to sanipratics apparatus technical field, particularly a kind of placing passed through inflation in the digestive tract cavity, to reduce part stomach volume, suitably reduce the purpose that food intake reaches controlling body weight.The force applications that also can utilize its generation of expanding is in the utensil of the intraorganic hemostasis by compression effect of human body internal cavity.
Background technology
Along with change, work and the living condition of The development in society and economy, dietary structure and the improvement of traffic, the obesity health problem that become international, the M ﹠ M of obesity also constantly raises thereupon, just day by day seriously endanger people's the health and the health of psychology, prevention and treatment of obesity have become the primary health problem of 21 century.Formulate overweight and fat Body Mass Index standard (the BodyMass lndex of measurement by World Health Organization (WHO), BMI) weigh, present Chinese overweight people is considerably beyond 6,000 ten thousand, overweight person is up to 200,000,000, sum of the two is 23.2%, near 1/4 of total population, people have adopted many kinds of means in order to lose weight, suffer very big loss economically.
General overweight or obesity can be advanced control and treatment by keeping on a diet, increase motion and several different methods such as medicine, acupuncture, but keep on a diet be difficult to lasting, keep fit through sport be difficult for taking effect, Drug therapy has wound body.Amount of literature data shows that lipposuction is unique permanently effective mode.It is exactly by dwindling the volume of stomach that a kind of mode is arranged in operative treatment, feel and the minimizing food intake than generation food early is full when allowing the patient take food, in this class mode there be comparatively sophisticated operation method: peritoneoscope stomach coronary artery bypass grafting (laparoscopic gastric RouX-en-Y bypass, LGBP), laparoscopic vertical band gastroplasty (laparoscopic vertical banded gastroplasty, LVBG), peritoneoscope controllability silicone stomach band (laparoscopic adjustable silicone gastric banding, LAGB) and micro-damage operation--gastric water polo Packing Technique (BioEnterics Intragastric Balloon, the method for weight-reducing of non-medicine such as BIB).
Gastric water polo Packing Technique be by fibergastroscope one not the water polo of water-filling send in the gastral cavity through esophagus, inject saline then by the water polo pack portion gastral cavity that swells, the stomach volume is reduced, and the feed back is eaten full sense raw and is reduced food intake than premature labor, reaches the effect of fat-reducing.This method is compared with other modus operandi, the patient is injured less, and the effectiveness of its treatment, safety have all obtained abundant approval, are widely used in many countries.Postoperative is with the minimizing of feed, and body weight can alleviate gradually, it is reported that using this postoperative body weight half a year can alleviate 6～35 kilograms.Yet this method yet has problems: the one, and the gastroscope operation is complicated, and operating time is longer, needs general anesthesia, therefore must be operated by the professional person, also has certain anesthetic risks.The 2nd, the gastroscope operation still is to have big misery concerning the patient, and bottleneck throat and esophagus are had certain damage.Especially place water polo and also will do gastroscopy again after four to six months water polo is taken out, not only inconvenience but also trouble are painful.Therefore, this method does not still obtain the large-scale popularization use.
Summary of the invention
The invention provides a kind of self-inflating air bag in digestive tract cavity, mainly solve existing gastric and settle the water polo fat-reducing to insert inconvenience, the problem that the patient is therefore painful.
In order to address the above problem, the utricule sealing of this self-inflating air bag in digestive tract cavity, include two kinds once mixing the aerogenesis thing that just generates gas in this utricule, have the gastric solubleness thing to be banded in outside the described utricule, described two kinds of aerogenesis things are isolated in respectively in the intravital different spaces of the capsule that is tied.The effect of gastric solubleness material is exactly to tie up utricule to allow two kinds of aerogenesis things be terminated in the intravital different spaces of the capsule that is tied, and in human stomach under the environment, again can very fast dissolving to remove tying up to utricule, allow two kinds of aerogenesis things mix and produce gas, utricule is expanded under the effect that generates gas, occupy the certain space of gastric, thereby produce the full sense of food when making user on the feed in advance, reaching reduction appetite, reduce food-intake and lose weight; This self-inflating air bag in digestive tract cavity can allow the patient swallow in the stomach voluntarily and use, the placement of need not performing the operation, and any of above-mentioned aerogenesis thing can be simple substance or mixture; Described gastric solubleness material can be any in medicinal gastric-dissolved capsule case material ribbon, bar and the satchel made.As concrete scheme, above-mentioned two kinds of aerogenesis things can be hydrogen peroxide and ferrous sulfate, also can be acetic acid and sodium bicarbonate, can also be citric acid and sodium bicarbonate, and described gastric solubleness material is any in the various gastric-dissolved capsule case materials.In above-mentioned various schemes, utricule can be made by the good material of any good springiness, air-tightness in epoxy natural rubber, silicon latex, butyl rubber, the thermoplastic elastomer polymer, on this utricule, be provided with gas bleeder valve, in the gas outlet of gas bleeder valve, do not dissolve by solution in the human body of pH＜6.0, and the valve plug that soluble material is made in the solution in the human body of pH 〉=6.0 sealing.
Above-mentioned valve plug can also be made by the stearic class material of fusing point between 40～45 ℃, also can also make by any material in cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, the hydroxypropyl methylcellulose acetate succinate by being made by the zymolytic cholesterol material of fat.
Owing to adopted such scheme, the present invention compared with prior art has following beneficial effect:
1, use this self-inflating air bag in digestive tract cavity, can allow the patient swallow in the stomach and use, the placement of need not performing the operation, therefore, to health without any mechanical damage.Suitable with Chinese medicine pill from inflation balloon capsular size, the too difficulty of swallowing for example, swell in the gastric inflation and occupy volume about 100 milliliters, and the volume of need swallowing is about 1.5cm
3This self-inflating air bag in digestive tract cavity of size.
2, the amount scalable of stomach volume reducing.The size of each air bag can be different, can make 100,150 on demand, the 200ML all size, what once placed can decide on demand, the stomach of wanting to contract is many just obey more several.Perhaps take one, slowly reduce gastric capacity, can reduce the incompatibility symptom of filling out behind the stomach like this every certain hour.
3, more be easy to generate satiety than stomach water polo.Air bag in light weight, always float over gastric content above, do not need too many appetite just can touch at the bottom of the stomach after the feed, stimulate coat of the stomach to produce satiety.According to the data of digestive physiology, the amount of food and matter can influence food-intake, and the capacity of food can directly stimulate coat of the stomach to cause the secretion of gastric acid.And gastric acid can increase the secretion of cholecystokinin (CCK), and the latter is the strongest to the influence of appetite, and the maincenter of acting on by CCK causes that full sense stops taking food.What secrete gastric acid is the parietal cell that secretes in the acid gland, and parietal cell mainly is distributed at the bottom of the stomach and body of stomach, therefore more is easy to generate satiety to producing the air bag that stimulates at the bottom of the stomach than the stomach water polo that sinks to greater gastric curvature and pylorus district.
4, intragastric balloon need not take out with operation.Elimination of the present invention can be the nature discharge of cooling down, gas in the air bag has certain pressure and gas difference of partial pressure, and the cyst wall that air-tightness is good more all can slowly breathe freely and volume reduces, when little to can pass through pylorus the time, will enter duodenum, excrete with feces at last.And when adopting gas bleeder valve of the present invention, adopt alkaline environment can to make by dissolved material down or in the intestinal owing to stop up the valve plug of bleeder port, when this air bag is little when entering intestinal, valve plug is dissolved to be opened, allow gas release, softish utricule is excreted with feces.When behind the air bag of the present invention of having swallowed as abnormal conditions needs occur in time in the elimination capsule during gas, can also oral immediately alkaline equilibrium liquid or the lecithin and the lipase of the effect of extremely strong emulsifying lipid arranged, the emulsifying branch that seals of air bag is taken off, just can be discharged the gas in the air bag, removing stimulates.
5, balloon can be discharged after slowly diminishing after a while voluntarily, therefore replenishes the balloon of desired volume at set intervals, just can long-term role.Do not resemble water polo and also will take out, be applicable to that long-term needs fill out the situation of stomach, until reaching predetermined effect with gastroscope every four to six months.
6, there have report stomach water polo to fill out the initial stage effect of stomach fat-reducing to be remarkable, but the effect after four months begins to reduce, so should not place for a long time.Analyzing possible reason from angle of physiology is: the water polo weight of 500ML is bigger, so always sink to greater gastric curvature portion and pylorus district, at any time greater gastric curvature is exerted pressure, stomach has the physiological characteristics of receptive relaxation, time has been grown its volume and can enlarge gradually, when the volume before expanding to and filling out stomach was suitable, the effect that subtracts the stomach appearance had just reduced.And air bag of the present invention fills out stomach and just may avoid this problem, and air bag is as balloon, and its very light in weight can not exerted pressure for a long time to stomach, and its stressed receptive relaxation that causes can reduce.
Description of drawings:
Fig. 1 is the structural representation of the present invention under the unaerated state.
Fig. 2 is the structural representation of the present invention under inflated condition.
Fig. 3 is the partial enlarged view of Fig. 2.
The specific embodiment
Fig. 1 is that employing the present invention makes to Figure 3 shows that, design swells is the self-inflating air bag in digestive tract cavity of 150 milliliters of specifications, it by utricule 1, be contained in net grid support 2, enteric film 3 valve plugs 4 in utricule 1 bleeder port and be banded in the outer banded gastric solubleness thing 7 of utricule 1, the hydrogen peroxide 6 and the ferrous sulfate 8 that are contained in the utricule 1 constitute, this self-inflating air bag in digestive tract cavity is encapsulated in the capsule 5 before use, and the manufactured goods size that contains capsule 5 is about 2CM
3Wherein utricule 1 epoxy natural rubber good by elasticity, that air-tightness is good is made, and net grid support 2 and valve plug 4 are made by the hard gel material; Enteric film 3 is that hydroxypropyl methylcellulose acetate succinate (HPMCAS) etc. is made.
When using this self-inflating air bag in digestive tract cavity, the patient swallows this self-inflating air bag in digestive tract cavity that volume is equivalent to the Chinese medicine pill size in the stomach, capsule 5 and banded gastric solubleness thing 7 dissolve under the effect of gastric juice, allowing utricule 1 remove ties up, after hydrogen peroxide 6 and ferrous sulfate 8 contact, hydrogen peroxide 6 is decomposed into oxygen G﹠W 9 under the catalytic action of ferrous sulfate 8, the oxygen of generation swells at gastric utricule 1.After using a period of time (general 1～2 month), oxygen slowly leaks and reduced volume from cyst wall in the capsule, when utricule little of can be when the pylorus, will enter duodenum, enter intestinal, valve plug 4 dissolved the opening of at this moment adopting enteric material to make allow residual gas release, the function that remaining frivolous utricule 1 and net grid support 2 can not have influence on intestines, it can excrete with feces.
In addition, fail inflation in time automatically, and be discharged into intestinal when inflating just now, valve plug 4 dissolved opening that enteric material is made and can prevent intestinal obstruction if this self-inflating air bag in digestive tract cavity meets accident at gastric.Moreover, when taking this self-inflating air bag in digestive tract cavity and have uncomfortable situation to take place, also can pass through oral alkaline equilibrium liquid, the valve plug 4 of air bag and enteric film 3 are melted away, thereby discharge the gas in the capsule, to remove stimulation.
According to principle of the present invention, the present invention also can make the utricule of suitable size and shape as required, and the present invention is used for hemostasis by compression in the body.
Claims (3)
1. self-inflating air bag in digestive tract cavity, utricule is arranged, it is characterized in that: described utricule sealing, in this utricule, include two kinds once mixing the aerogenesis thing that just generates gas, have the gastric solubleness thing to be banded in outside the described utricule, described two kinds of aerogenesis things are isolated in respectively in the intravital different spaces of the capsule that is tied; Described two kinds of aerogenesis things are hydrogen peroxide and ferrous sulfate; Described gastric solubleness thing is any bar made and in the satchel any in the various medicinal gastric-dissolved capsule case materials; Described utricule is made by the good material of any good springiness, air-tightness in epoxy natural rubber, silicon latex, butyl rubber, the thermoplastic elastomer polymer; On this utricule, be provided with gas bleeder valve, in the gas outlet of gas bleeder valve, do not dissolve by solution in the human stomach of pH＜6.0, and the valve plug that soluble material is made in the solution in the human body intestinal tube of pH 〉=6.0 sealing.
2. self-inflating air bag in digestive tract cavity according to claim 1 is characterized in that: described valve plug is made by the stearic class material of fusing point between 40～45 ℃, or can be made by the zymolytic cholesterol material of fat.
3. self-inflating air bag in digestive tract cavity according to claim 1 is characterized in that: described valve plug is made by any material in cellulose acetate phthalate, Hydroxypropyl Methylcellulose Phathalate, the hydroxypropyl methylcellulose acetate succinate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810300628A CN100591289C (en) | 2008-03-19 | 2008-03-19 | Self-inflating air bag in digestive tract cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810300628A CN100591289C (en) | 2008-03-19 | 2008-03-19 | Self-inflating air bag in digestive tract cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101249006A CN101249006A (en) | 2008-08-27 |
| CN100591289C true CN100591289C (en) | 2010-02-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810300628A Expired - Fee Related CN100591289C (en) | 2008-03-19 | 2008-03-19 | Self-inflating air bag in digestive tract cavity |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045477A2 (en) | 2008-10-16 | 2010-04-22 | Obalon Therapeutics, Inc. | Intragastric volume-occupying device and method for fabricating same |
| WO2012099609A1 (en) | 2011-01-21 | 2012-07-26 | Obalon Therapeutics, Inc. | Intragastric device |
| CA2902644C (en) * | 2013-03-15 | 2020-09-22 | Obalon Therapeutics, Inc. | Intragastric device |
| CN105250060B (en) * | 2015-10-13 | 2018-05-08 | 中国人民解放军第二军医大学 | A kind of stomach volume reduction slimming capsule |
| WO2018085079A1 (en) | 2016-11-04 | 2018-05-11 | Obalon Therapeutics, Inc. | Pressure control system for intragastric device |
| CN106511372A (en) * | 2016-11-23 | 2017-03-22 | 邹立新 | Intragastric self-expanding weight-reducing drug |
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2008
- 2008-03-19 CN CN200810300628A patent/CN100591289C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN101249006A (en) | 2008-08-27 |
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