CN101056596B - 用于治疗心脏瓣膜反流的装置和方法 - Google Patents

用于治疗心脏瓣膜反流的装置和方法 Download PDF

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CN101056596B
CN101056596B CN2005800386720A CN200580038672A CN101056596B CN 101056596 B CN101056596 B CN 101056596B CN 2005800386720 A CN2005800386720 A CN 2005800386720A CN 200580038672 A CN200580038672 A CN 200580038672A CN 101056596 B CN101056596 B CN 101056596B
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CN101056596A (zh
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A·扎凯
D·罗藤伯格
D·米沙利
D·阿伦
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Edwards Lifesciences AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/246—Devices for obstructing a leak through a native valve in a closed condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A61F2/2466—Delivery devices therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12009—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot
    • A61B17/12013—Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot for use in minimally invasive surgery, e.g. endoscopic surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A61B2017/00783—Valvuloplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00867—Material properties shape memory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0066—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof shrinkable

Abstract

在一个实施例中，本发明提供了可以植入在心脏内以至少部分地阻塞可能位于两个二尖瓣小叶之间的间隙的假体。在一个优选实施例中，假体包括在左心房内扩张以锚定假体的锚定圈和固定到锚定圈的袋部件。袋部件定位在二尖瓣内，在小叶之间，从而使袋部件的开放端定位在左心室内。当二尖瓣开放的时候，血液流过袋部件，使袋部件维持在塌陷状态下。当二尖瓣闭合的时候，血液的反压推动到袋部件内，使袋部件扩张到膨胀的形状。二尖瓣小叶接触扩张的袋部件，允许假体阻塞在小叶之间的开口的至少部分，由此使反流的血流进到左心房内最小。

Description

用于治疗心脏瓣膜反流的装置和方法
                        相关申请
本申请要求对序列号为60/609,345的于2004年9月14日提出的题目为“Device and Method for Reducing Mitral Valve Regurgitation”的美国临时申请和序列号为60/657,919的于2005年3月3日提出的题目为“Device and Method for Reducing Mitral Valve Regurgitation”的美国临时申请的优先权；在这里，这两项申请都通过参考予以合并。
背景技术
二尖瓣是人心脏的最至关重要的四个瓣膜中的一个，防止血液在心脏收缩期间从左心室反流到左心房内。位于左心房和左心室之间，二尖瓣包括两个定位成在闭合状态下阻塞血液流动而在开放状态下允许血液流动的小叶。
通过在左心房和左心室之间的压力差，并且通过由从二尖瓣小叶的自由边缘延伸到在心脏的心室壁上的乳头肌的胶原绳状结构即所谓的腱索组成的复杂网络，二尖瓣开放和闭合。当乳头肌收缩的时候，它们拉动小叶，由此使二尖瓣开放，允许血液流动到左心室内。当乳头肌松弛的时候，在小叶上的拉力减小，使二尖瓣闭合，由此阻塞血液流动到左心室内。
当瓣膜小叶不能接合或完全闭合的时候，二尖瓣的正常操作可能受到损害，允许反流的血液流回到左心房内。引起这种二尖瓣反流的常见原因是先天性瓣膜缺陷或心脏几何形状由于疾病发生变化。例如，感染可能使二尖瓣环变大，由此使瓣膜小叶的位置和取向发生变化。在另一个例子中，二尖瓣缺陷可能使小叶脱垂或不匹配，允许血流反流回左心房。
一种治疗不全的二尖瓣的先前的办法包括以手术方式用人造瓣膜进行替换。在这些措施中，典型地，对患者进行开心手术，以用机械或生物来源的瓣膜替换不健全的瓣膜。尽管随着时间过去这种治疗措施得以改进，但大量限制仍然存在。例如，对二尖瓣进行移除和替换具有很大的侵入性，因此大大增加了出现严重并发症例如感染或排斥的风险。
其它手术技术得以发展，以减小必需用瓣膜替换方法对心脏进行再造的量。一种这样的技术已知为蝴蝶结修补，在其中，每个二尖瓣小叶的中心区域都缝合在一起。另一种技术包括形成围绕瓣膜环的安抚件，由此减小瓣膜环的截面面积。尽管与瓣膜替换方法相比，这些技术需要进行较少再造，但仍然需要进行相当大量再造。此外，在手术结束之前，对手术措施的效力进行评估可能是困难的。
在又一种技术中，瓣环成形圈缝在二尖瓣的环内。由于环形成圈的直径小于二尖瓣环的直径，所以瓣膜的小叶移动到一起，增加接合。除了也具有很大的侵入性之外，环形成圈通常使二尖瓣的自然弯曲的形状发生扭曲，并且还可能限制环的收缩性。
尽管以上所描述的技术在治疗二尖瓣缺陷方面取得了一些成功，但要求对心脏进行少的再造或不需要对心脏进行任何再造的额外的治疗措施是需要的。此外，可以在侵入性最小化的情况下进行但还可以更有效地减小或消除二尖瓣反流的额外的治疗是需要的。
发明目的和内容
本发明的目的是克服现有技术的限制。
本发明的目的是提供用于治疗二尖瓣反流的改进的方法和装置。
本发明的另一个目的是提供减小血液反流到左心房内的假体装置。
本发明的又一个目的是提供可以经皮递送并且在患者体内展开的假体装置。
本发明的另一个目的是提供可以动态地对在二尖瓣小叶之间的间隙进行填充的假体装置。
本发明的另一个目的是提供可以减小二尖瓣反流的大多数病理状况的假体装置。
通过提供可以植入在心脏内以至少部分地使可能位于两个二尖瓣小叶之间的间隙阻塞的假体，本发明试图达到这些目的及在此没有明确列举的其它目的。在一个优选实施例中，假体包括在左心房内扩张以锚定假体的锚定圈和固定到锚定圈的袋部件。袋部件定位在二尖瓣内，在小叶之间，从而使袋部件的开放侧定位在左心室内。当二尖瓣开放的时候，血液流过袋部件，使袋部件维持在塌陷状态下。当二尖瓣闭合的时候，血液的反压推入袋部件，使袋部件扩张到膨胀的形状。二尖瓣小叶接触扩张的袋部件，允许假体阻塞在小叶之间的开口的至少部分，由此最小化反流的血流到左心房内。
本发明的另一个优选实施例提供了用于治疗瓣膜反流的装置，包括：
确定尺寸为至少部分地放置在瓣膜的小叶之间的接合部件，所述的接合部件具有扩张状态和缩小状态，并且具有大致上等于所述的小叶的连合处的长度；和
连接到所述的接合部件的锚定结构，所述的锚定结构具有确定尺寸为配合在递送导管内的压缩状态和确定尺寸为固定在邻近所述的瓣膜的腔的壁的至少部分上的扩张状态。
本发明的另一个优选实施例提供了治疗瓣膜反流的方法，包括：
将假体加载在递送导管内，所述的假体包括锚定部分和接合部分；
使所述的递送导管前进到心脏的腔；
在瓣膜内展开所述的接合部分；
使所述的锚定部分扩张，以接触所述的腔的壁；和
将所述的接合部分支撑在所述的瓣膜的连合处内。
本发明的另一个优选实施例提供了用于在心脏收缩期间大致上阻塞在瓣膜内血流的装置，包括：
具有侧向尺度的柔性部件；
连结到所述的柔性部件并且确定形状为沿着所述的瓣膜的小叶的连合处长度定位所述的柔性部件的所述的侧向尺度的支撑部件；
连结到所述的支撑部件的锚定部件，所述的锚定部件包括压缩构型和扩张构型；
在其中，所述的锚定部件的所述的扩张构型确定形状为将所述的支撑部件至少部分地定位在所述的瓣膜内。
附图说明
图1A图示了根据本发明的一个优选实施例的假体的前视图；
图1B图示了图1A的假体的透视图；
图1C图示了在扩张构型内的图1A的假体的剖面图；
图1D图示了在缩小构型内的图1A的假体的剖面图；
图2A图示了在二尖瓣内的在缩小构型内的图1A的假体的底视图；
图2B图示了在二尖瓣内的在扩张构型内的图1A的假体的底视图；
图3A图示了在二尖瓣内的在缩小构型内的图1A的假体的剖面图；
图3B图示了在二尖瓣内的在扩张构型内的图1A的假体的剖面图；
图4图示了在递送导管内的图1A的假体的前视图；
图5A图示了根据本发明的另一个优选实施例的假体的前视图；
图5B图示了图5A的假体的侧视图；
图5C图示了图5A的假体的透视图；
图5D图示了图5A的假体的透视图；
图6图示了在心脏内的图5A的假体的侧视图；
图7A和7B图示了在递送导管内的图5A的假体的侧视图；
图8A和8B图示了带有收回线的图5A的假体的侧视图；
图9A图示了根据本发明的另一个优选实施例的假体的前视图；
图9B图示了图9A的假体的侧视图；
图9C图示了图9A的假体的透视图；
图9D图示了图9A的假体的透视图；
图9E图示了在图9D中的区域9E的放大图；
图10A图示了根据本发明的另一个优选实施例的假体的前视图；
图10B-10D图示了图10A的假体的多种透视图；
图11图示了在从递送导管展开期间的图10A的假体的侧视图；
图12A图示了根据本发明的另一个优选实施例的假体的前视图；
图12B图示了图12A的假体的侧视图；
图12C-12E图示了图12A的假体的多种透视图；
图13图示了在心脏内的图12A的假体的侧视图；
图14A图示了根据本发明的另一个优选实施例的假体的前视图；
图14B图示了图14A的假体的侧视图；
图14C图示了图14A的假体的顶视图；
图14D和14E图示了图14A的假体的多种透视图；
图15图示了在心脏内的图14A的假体的侧视图；
图16A和16B图示了在递送导管内的图14A的假体的侧视图；
图17A图示了根据本发明的另一个优选实施例的假体的前视图；
图17B图示了图17A的假体的顶视图；
图17C和17D图示了图17A的假体的透视图；
图18A图示了根据本发明的另一个优选实施例的假体的前视图；
图18B和18C图示了图18A的假体的多种透视图；
图18D图示了在图18B中的区域18D的放大图；
图19A图示了根据本发明的另一个优选实施例的假体的前视图；
图19B和19C图示了图19A的假体的多种透视图；
图19D图示了在图19B中的区域19D的放大图；
图20A图示了根据本发明的另一个优选实施例的假体的前视图；
图20B和20C图示了图20A的假体的多种透视图；
图21A图示了在部分展开构型内的图20A的假体的侧视图；
图21B图示了在图21A中的区域21B的放大图；
图22A图示了根据本发明的另一个优选实施例的假体的前视图；
图22B和22C图示了图22A的假体的多种透视图；
图23A图示了根据本发明的另一个优选实施例的假体的前视图；
图23B图示了图23A的假体的顶视图；
图23C和23D图示了图20A的假体的多种透视图；
图24A图示了根据本发明的另一个优选实施例的假体的前视图；
图24B图示了图24A的假体的侧视图；
图24C和24D图示了图20A的假体的多种透视图；
图24E图示了在图24D中的区域24E的放大图；
图25图示了根据本发明的另一个优选实施例的在心脏内的假体的侧视图；
图26A图示了根据本发明的另一个优选实施例的在心脏内的假体的侧视图；和
图26B图示了图26A的假体的截面图。
具体实施方式
本发明试图减小在心脏收缩的心脏收缩期期间从左心室流动到左心房内的血液的量。这种二尖瓣反流的大多数情况由二尖瓣小叶的差接合引起，当二尖瓣闭合的时候，差接合的二尖瓣小叶在这些小叶之间形成开口。本发明减小在二尖瓣小叶之间的这些开口的尺寸，而在一些情况下，完全消除开口，允许二尖瓣在很少发生反流或不发生任何反流的情况下发挥功能。在至少一些在本说明书中所描述的作为例子的实施例中，通过将部件定位在两个二尖瓣小叶之间，以当闭合的时候，使在小叶之间的开口闭合或填充在小叶之间的开口，这得以实现。
图1A-4
在图示了根据本发明的假体100的优选实施例的图1A-4中，可以看到一种这样的设计。假体100包括由柔性材料104形成的布置在圈102上的袋106。如在图1B中所最佳看到的那样，袋106包括下部开放端106A，当在心脏124的二尖瓣120内适当地取向的时候，当二尖瓣120闭合的时候，下部开放端106A扩张，阻塞在二尖瓣小叶122之间的任何开口。此外，当二尖瓣120开放的时候，袋106收缩或缩小，使从左心房126到左心室128的血流最大化。就此而言，袋106可以更一般地描述为可扩张的闭塞部件或接合部件。
优选地，通过在线108或围绕线108将至少两层柔性材料104粘合、缝纫或用其它手段附着，袋106形成。这些层可以用两片不同的材料实现，或用靠着自身折叠的单片材料实现。优选地，柔性材料104由心包组织或带有类似柔性的其它生物或人造材料例如牛的组织、聚氨酯或如编号为6,764,510的美国专利所描述的那样的材料制造，在这里，这项专利的内容通过参考予以合并。袋106的形状和柔性织物108的柔性允许袋106如在图1D、2A和3A中所最佳看到的那样达到缩小位置，并且允许袋106如在图1C、2B和3B中所最佳看到的那样达到扩张状态。
尽管袋106可以确定形状为多种不同的构型，但有助于血液流入袋106和从袋106流出的袋形状，例如袋106的倒圆的弯弓形状是优选的。包括尖锐的角部或粗糙的接缝的袋106的构型由于它们对血流进入袋106内和从袋106出来的中断作用而不是优选的。优选地，如在图2B中所最佳看到的那样，袋106也包括类似于二尖瓣120的全长并且更优选地大致上类似于二尖瓣连合处的长度的全长，允许袋106填充可能沿着小叶122的长度存在的任何开口。尽管单个的袋106是优选的，但额外的袋或在袋内的分隔件也可以包括在本发明内。
圈102优选地由弹性的形状记忆材料，例如镍钛诺制造，这种材料允许假体100如在图4中所看到的那样压缩或加载到递送导管110内，然后如在图3A和3B中所看到的那样在左心房126内扩张到预定形状。圈102确定尺寸为压靠在心脏124的左心房126的壁上，而在一些构型内，压靠在二尖瓣120的连合处内，由此锚定假体100的位置，同时将袋106定位成至少部分地经过二尖瓣120。额外地，袋106的下部开放端106A定位在左心室128附近或定位在左心室128内。就此而言，圈102可以更一般地描述为锚定框架或锚定结构。
一旦定位在心脏124内，假体100就以类似于心脏瓣膜的方式发挥功能，在心脏舒张期间开放，而在心脏收缩期间闭合。更特殊地，当血液从在左心房126的顶部附近的肺静脉125流进左心房的时候，血流向下朝向二尖瓣120移动。当血流到达二尖瓣120的时候，当二尖瓣120通过乳头肌开放的时候，血流推靠二尖瓣小叶122。如在图3A中所看到的那样，血流也推靠假体100的袋106，使可能在袋106内的任何血液出来，并且使袋106呈现大致上缩小或压缩的位置。袋106的这种压缩构型提供了使血流阻力和在左心房内的装置可能另外引起的其它中断作用最小化的流线形轮廓。就此而言，血流在心脏舒张期间通到左心房126内，经过二尖瓣120并且经过假体100，以允许血流通到左心室128内。
在心脏收缩期间，当乳头肌使这些小叶122移动到闭合位置的时候，由来自左心室128内的血液的反压压靠在二尖瓣小叶122上。额外地，在左心室128内的血液的该反压进入到假体100的袋106内，使袋106如在图3B中所看到的那样达到扩张形状。二尖瓣小叶124如在图2B中所最佳看到的那样接合靠在扩张的袋106上，使可能另外位于两个小叶122之间的间隙最小化，或甚至消除这些间隙。因而，在心脏收缩期间的血流使假体100扩张，以减小或消除可能另外位于小叶122之间的任何开口，最终减小或防止血液反流到左心房126内。
部分地由于袋106的动态的柔性的特性，假体100可以在不需要等大范围的袋尺寸的情况下，扩张成填充在小叶122之间的大范围的开口尺寸。换言之，相同尺寸的袋106可以扩张成填充在二尖瓣小叶122之间的相对小的开口或相对大的开口。因而，相同尺寸的假体100可以适合于患有相对严重的二尖瓣反流及相对轻缓的二尖瓣反流的患者。然而，不同尺寸的假体100可以适合于不同尺寸的二尖瓣120，因为优选的是，袋106沿着二尖瓣的连合处的长度或在两个小叶之间的“会合线”的长度延伸。
如在图4中所看到的那样，假体100优选地通过导管110经皮递送到左心房126。例如，递送导管110可以经过股静脉供给到右心房内，并且经过在心房隔膜125内的预制的穿孔。在另一个例子中，递送导管110可以经过股动脉而进到主动脉内，经过主动脉瓣膜并且进到左心室内。
可选择地，在开心手术期间，假体100可以经过在心脏125的心房壁内的开口插入到左心房126内。虽然在开心过程期间假体100可以更容易地看到和定位，但经皮递送具有很小的侵入性，因此包括大致更低的并发症的风险。
图5A-8B
在图5A-7B中，可以看到根据本发明的假体200的另一个优选实施例。尽管大体上类似于假体100，但假体200还包括四个扩张成将假体200锚定在左心房126内并且沿着二尖瓣连合处的长度将袋206定位在二尖瓣小叶122之间的锚定环202。就此而言，锚定环202可以更一般地描述为锚定框架或锚定结构。
袋206由为袋206提供了支撑框架的支撑臂204和底部支撑件208支撑。优选地，侧臂204和底部支撑件208是连接到锚定环202的单根的一体的丝，然而，例如通过焊接或锡焊等，多段的丝可以连接在一起。如先前所描述的假体100的实施例那样，支撑臂204和底部支撑件208优选地包括弹性的形状记忆材料，例如镍钛诺，其允许假体200如在图7A和7B中所看到的那样压缩并且加载到导管110内，然后如在图5A-6中所看到的那样展开到预定形状。优选地，用于支撑臂204和底部支撑件208的丝确定尺寸和形状为使小叶122的自由边缘变形最小，因此使二尖瓣几何形状扭曲最小。就此而言，袋支撑臂204可以可选择地描述为框架、支撑结构或定位架。
袋206类似于先前实施例的袋106，优选地包括柔性的生物或人造材料，其确定尺寸和形状为形成带有反向于锚定环202的开口的袋形状。袋206可以直接缝纫、粘合或附着到用于支撑的外部支撑臂204。可选择地，袋206的柔性织物可以缝纫为形成用于在袋206的外部表面上的支撑臂204的延长的通道。
如在图6中所最佳看到的那样，袋206至少部分地定位在二尖瓣120内，从而使袋206的开放端面向左心室128。在这种构型内，袋206在心脏舒张期间缩小，使血流在二尖瓣120内阻塞最小，而在心脏收缩期间扩张，至少部分地填充在二尖瓣小叶122之间的任何开口，由此使血流反流到左心房126内最小。
如就假体100所描述的那样，假体200优选地通过经皮递送导管110递送到左心房126，但也可以在开心手术期间植入。由于袋206具有在二尖瓣120内需要特殊取向的水平延长的形状，所以与在开心手术期间进行递送相比，经皮将假体200递送到适当的位置可能是较困难的。因此，如在图8A和8b中所看到的那样，递送导管110可以包括收回线210和推杆212，以将假体200收回到导管110内，而在左心房126内新的位置将假体200重新展开。
优选地，收回线210包括细但强的材料，例如金属、丝或聚丙烯，并且是单段的。收回线210的两个自由端都定位在递送导管110的近端，同时线210的主体延伸经过递送导管110、经过每个锚定环202而往回经过导管110。
基于在扩张状态下的假体200的构型，收回线210单独可能提供不了完全将假体200重新压缩并且重新捕获所需要的力。在这样的情况下，推动件杆212可以与收回线210一起使用，以操纵假体200形成适合于重新捕获在递送导管110内的形状。例如，递送导管110的操作者可以拉动收回线210，同时用推动件杆212推动锚定环202。同时进行推动和拉动使锚定环202变形成可以较容易地被递送导管110重新捕获的延长的形状，允许使用者重新定位递送导管110的远端，并且将假体200重新展开。
图9A-9E
图9A-9E图示了假体250的另一个优选实施例，其大部分类似于先前在图5A-8B中所显示的假体200，具有固定到支撑臂258的锚定环252和布置在支撑臂256之间的袋254。然而，如在图9E中所最佳看到的那样，本假体250的支撑臂258定位并且接附在袋254内而不是在袋254的外部表面上，与假体200比较，形成了更均匀的外部表面形状。额外地，底部支撑件256包括构造为将力施加靠在支撑臂258上以使袋254维持完全扩张的位置的环256A。
图10A-11
图10A-11图示了根据本发明的假体300的又一个实施例，其大体上类似于本说明书的先前所描述的实施例，具有支撑由柔性材料制造的袋306的支撑臂304。
不同于在本说明书中先前所描述的实施例，假体300包括与支撑臂304一体的锚定笼302。优选地，例如通过用激光将管切制成想要的样式，或通过用于制造支架的其它技术，锚定笼302和支撑臂304由单根的金属管切制。组成管的金属优选地包括形状记忆材料，例如通常用于支架的那些材料，例如镍钛诺。就此而言，锚定笼302可以更一般地描述为锚定框架或锚定结构。
与在本说明书中先前描述的实施例相比，一旦在左心房126内扩张，锚定笼302就在更多的位置内接触左心房126的组织，因此更均匀地将锚定力分配在左心房126内。额外地，锚定笼302的扩张形状可以确定形状为更好地符合于左心房126的几何形状，因此更准确地将袋306定位在想要的部位。
如本说明书的先前所描述的实施例那样，如在图11中所看到的那样，假体300优选地用递送导管110经皮递送，但可以可选择地在开心手术期间展开。如在图11中所看到的那样，在经皮展开的情况下，假体300压缩到相对小的展开前状态。
图12A-13
图12A-13图示了根据本发明的假体400的另一个优选实施例，其大体上类似于先前所描述的实施例，例如在图5A-8B中所显示的假体200。更特殊地，假体400类似性包括经由支撑臂404锚定并且定位袋406的锚定环402。袋406类似地定位在二尖瓣120内，从而当二尖瓣120闭合的时候，扩张到在二尖瓣小叶122之间的任何开口内。
与先前所描述的实施例对比，假体400包括多个锚定环402，这些锚定环402形成具有终止区域408的球形的柠檬形状。锚定环402的整体形状扩张成以不同的角度将压力施加靠在左心房126上，这更好地维持了假体400的位置。额外地，终止区域408可以压靠在左心房126的组织上，或可以可选择地定位在位于左心房126的壁内的切口(例如在心房隔膜内的经皮进入切口)内，以进一步提供锚定支撑。
假体400的主体包括确定形状为形成锚定环402的丝402A-402E及两个袋支撑件404。丝402B、402C和402D确定形状为具有大体上为圆形的形状，而自由端中的每个都被终止区域408捕获。就此而言，每根丝402B、402C和402D都形成假体400的单个的环。
丝402A的一端固定在终止区域408内，而另一端向下延伸为形成袋支撑件404，在两端之间包括弯弓形状，形状类似于丝402B、402C和402D所形成的形状。第二个袋支撑件404由类似地固定在终止区域408内的丝404E形成。如在本说明书中先前所描述的实施例那样，如在图13中所最佳看到的那样，袋406固定到袋支撑件404，由此在二尖瓣120内将袋406维持在想要的部位。就此而言，锚定环402可以更一般地描述为锚定框架或锚定结构。
图14A-16B
在于图14A-16B中所图示的另一个优选实施例中，显示了根据本发明的假体500。类似于在本说明书中所讨论的先前实施例，假体500包括由锚定丝502支撑和定位的袋506。尽管本假体500包括弯曲的锚定区域502A，类似于先前所讨论的实施例的弯曲的锚定丝，但这些锚定区域502A包括单根的锚定丝502。通过使用单根的锚定丝502，假体500使可能另外存在的尖锐的端部或边缘最少化。就此而言，锚定丝502可以更一般地描述为锚定框架或锚定结构。
如在图16A和16B中所看到的那样，一种递送假体500的可能的方法包括将假体500压缩或加载在经皮递送导管110内，并且将假体500递送到左心房126。一旦在左心房126内，假体500就扩张到在图15中所看到的预定形状。因而，类似于先前所讨论的实施例，假体500维持了袋506在二尖瓣120内的位置，减小了反流。
图17A-17D
图17A-17D图示了根据本发明的假体600的又一个优选实施例，类似于在本说明书中先前所描述的实施例，通过将袋606锚定在二尖瓣120内，其减小了二尖瓣反流。
相反地，本假体600包括确定形状为具有更紧密地相似于左心房126的不对称内部的不对称蛋结构的锚定丝602。由于锚定丝602的不对称性匹配于左心房126的自然不对称性，所以假体600自身在预定位置内扩张和取向，提供袋606与二尖瓣120稳定锚定和一致对准。此外，这种不对称的设计有助于从经过心房隔膜的切口的位置进行递送和展开，因为假体600扩张成牢固地接合左心房126的几何形状。就此而言，锚定丝602可以更一般地描述为锚定框架或锚定结构。
当完全扩张的时候，袋606也包括放射状或圆筒形的形状，并且可以更一般地描述为可扩张的闭塞部件或接合部件。无论袋606相对于二尖瓣小叶122(即二尖瓣120的连合处)如何进行转动取向，放射状的形状都施加类似的均匀液压功能。就此而言，在对减小反流没有不利影响的情况下，假体600可以展开为更多的取向。
图18A-18D
图18A-18D显示了根据本发明的假体700的另一个优选实施例，其很像先前所描述的假体600，具有形成类似于左心房126的几何形状的不对称形状的锚定丝702。然而，本假体700包括带有延长的非放射状形状的袋706，其通过转动旋转件710连结到锚定丝702。旋转件710允许在袋706和锚定丝702之间进行转动，无论锚定丝702如何取向，都允许袋706在二尖瓣120内达到想要的转动取向。就此而言，锚定丝702可以更一般地描述为锚定框架或锚定结构。
如在图18D中所最佳看到的那样，旋转件710包括从袋706的看不到的丝支撑件延伸的丝环708。锚定丝702包括盘绕且由此接合丝环708的丝卷704，允许锚定丝702相对于袋706进行转动。就此而言，通过首先在二尖瓣120内将袋706定位在想要的位置，然后在不需要对假体700的整体转动取向进行调整的情况下，将锚定丝702展开，外科医生可以更容易地经皮将假体700展开。额外地，假体700转动的能力允许袋706自身对准，从而使每个二尖瓣小叶122接触靠在袋706的延长侧上。
图19A-19D
图19A-19D图示了假体800的优选实施例，其类似于在本说明书中先前所描述的实施例，尤其是在图18A-18D中所显示的假体700。更特殊地，假体800包括扩张成类似于左心房126的几何形状的不对称形状的锚定丝802。额外地，假体800包括通过转动连合件810连结到锚定丝802的延长的袋806。就此而言，锚定丝802可以更一般地描述为锚定框架或锚定结构。
与先前所描述的假体700对比，假体800包括袋支撑丝804，其不但如在本说明书中在其它实施例中所描述的那样支撑袋806的结构，而且如在图19D中所最佳看到的那样围绕圆柱件808缠绕，然后径向向外分支成环形状804A。锚定丝802的端部连结在圆柱件808内，从而允许锚定丝806相对于袋806进行自由的转动。
袋支撑丝804的成环区域804A有助于自由转动的袋806在二尖瓣120内自身取向成想要的位置。额外地，这些外部成环区域804A可以确定尺寸和形状为通过位于二尖瓣120的环上而支撑袋806。
可选择地，袋支撑丝804的成环区域可以确定形状为至少部分地与锚定丝802的部分相互锁定，以允许锚定丝802在袋支撑丝804的环的长度所确定且因此约束的范围内进行自由的转动。通过允许至少在一定程度上对在展开构型内的袋806进行转动控制，这样的转动约束可以更好地有助于外科医生进行递送和展开。
图20A-21B
图20A-21B图示了根据本发明的假体900的又一个优选实施例，其大体上类似于本说明书的先前所讨论的实施例，例如图17A-17D的假体600。例如，假体900包括具有放射状形状的袋906和袋支撑丝908及固定到袋906并且具有大体上匹配于左心房126的内部几何形状的不对称形状的锚定丝902。
然而，假体900包括两个可分别展开的支撑结构：先前所提及的锚定丝902和内部支撑丝904。内部支撑丝904包括延长区域904A和锚定区域904B，锚定区域904B作为支撑丝908而在袋906内延续。锚定丝902和内部支撑丝904可以更一般地描述为锚定框架或锚定结构。
如在图21A和21B中所最佳看到的那样，在用递送导管110进行经皮递送期间，支撑结构902和904可以分别展开。当假体900被推出递送导管110的时候，包括延长区域904A和锚定区域904B的内部支撑丝904首先扩张，同时锚定丝902保持相对压缩。
锚定区域904B的扩张形状优选地确定尺寸和形状为接合二尖瓣120的环的至少部分。就此而言，使用者可以将袋906引导到在二尖瓣120内的想要的位置，同时锚定区域904B扩张成至少部分地将袋906锚定在适当的位置。一旦使用者达到用于袋906的想要的位置，剩余的锚定丝902就可以从递送导管110展开，允许其扩张成压靠在左心室126上，由此进一步将假体900锚定在适当的位置。
图22A-22C
图22A-22C图示了根据本发明的假体1000的又一个优选实施例。大体上，这个假体1000类似于在本说明书中先前所描述的实施例，例如图17A-17D的假体600，包括锚定丝1002、袋支撑丝1004和具有放射状形状的袋1006。
除了这些类似性之外，假体1000包括朝向袋1006的开放端弯曲的锚定丝1002的区域1002A。当在左心房126内扩张的时候，本发明的区域1002A至少部分地接触二尖瓣120的环。这个环支撑件防止袋1006被推动成经过二尖瓣120而进到左心室128内，在左心房120内维持了假体的整体垂直位置。就此而言，锚定丝1002可以更一般地描述为锚定框架或锚定结构。
图23A-23D
现在翻到图23A-23D，显示了根据本发明的假体1100的又一个优选实施例。再次地，这个假体大体上类似于在本说明书中所描述的先前实施例，包括具有延长的形状的袋1106、锚定丝1102和部分地支撑袋1106并且从袋1106的顶部部分延伸出来的下部环1104。
然而，锚定丝1102的自由端围绕下部环1104卷绕，允许锚定丝1102的环在下部环1104上枢转，以达到更复杂的锚定构型。通过达到更复杂的锚定构型，假体1100可以更好地支撑，因此随着时间过去更恒定地定位袋1106。就此而言，锚定丝1102可以更一般地描述为锚定框架或锚定结构。
图24A-24E
图24A-24E图示了根据本发明的假体1200的另一个优选实施例，具有带有延长的形状的袋1206、作为在袋1206内的看不到的袋支撑丝的部分的枢转环1204和具有围绕枢转环1204卷绕的区域1210以形成自由转动枢转件1212的锚定丝1202。
如在图24E中所最佳看到的那样，为了使锚定丝1202的设计额外地复杂，锚定丝的部分用针织件1208彼此固定。通过达到额外的复杂性并且使结构成环，假体1200能够更好地锚定在左心房126内，因此将自身固定在左心房126内。此外，针织件1208允许锚定丝1202的结合区域相对于彼此进行铰接，这可以允许在递送导管110内的装填更有效，或使在左心房126内的展开手段更复杂。就此而言，锚定丝1202可以更一般地描述为锚定框架或锚定结构。
图25
翻到图25，图示了根据本发明的假体1300的又一个优选实施例。特殊地，假体1300展示了袋1306，袋1306具有大体上类似于在本说明书中先前所描述的实施例的袋支撑件1304，并且还包括连结到袋支撑件1304的支架锚定件1302。就此而言，支架锚定件1302可以更一般地描述为锚定框架或锚定结构。
如在本领域中所知道的那样，支架锚定件1302可以包括多种不同的材料和结构。例如，在编号为6,936,067、6,929,658、6,926,743、6,923,828和6,902,575的美国专利中，可以看到一些支架技术；在这里，每项专利的内容都通过参考予以合并。
图26A-26B
翻到图26A和26B，图示了根据本发明的假体1400的又一个优选实施例，其包括用于袋1406的可选择的锚定和定位系统。特殊地，具有多个隔膜接附臂1402的定位臂1402锚定在心房隔膜125内，隔膜接附臂从定位臂1402的基部延伸，并且压靠在心房隔膜125的右侧和左侧上。优选地，隔膜接附臂1402的尺寸和形状类似于在本领域中所知道的心房隔膜闭合装置的尺寸和形状。就此而言，定位臂1402可以更一般地描述为锚定框架或锚定结构。
就此而言，假体1400可以经由在心房隔膜125内的切口进行递送，首先将袋1406定位在二尖瓣120内，然后为了进行锚定支撑而将隔膜接附臂1404延伸成靠在心房隔膜125的右侧和左侧上。定位臂1402大致上使在心房隔膜125内的切口闭塞，同时隔膜接附臂1402保持围绕定位臂1402的隔膜组织，防止血液经过隔膜125之间。
尽管在本说明书中所披露的优选实施例包括可扩张的袋，但应该理解的是，其它设计可以与本发明所想到的锚定设计一起使用。例如，结实并且优选柔性的片部件可以可选择地使用，其具有类似的形状和尺寸，如就本说明书的实施例的袋所描述的那样。
优选地，结实的部件是相对柔软的，具有允许在一定程度上进行压缩的柔性，尤其是当被二尖瓣小叶接触的时候。更优选地，通过将两片心包组织附着在一起，并且提供支撑部件或丝，类似于就在先前实施例中的袋所描述的，结实的部件可以形成。镍钛诺细线代替支撑部件而可以接附到结实的部件和左心室128，防止结实的部件移动到左心房126内。替代地，结实的部件可以包括弹性的生物相容的聚合物材料，例如聚氨酯。
优选地，本说明书的实施例也可以包括连接锚定环或锚定丝的柔性的聚合物片，例如聚氨酯，锚定环或锚定丝接触左心房126。就此而言，通过更均匀地分配锚定力，柔性的片进一步减小了在左心房壁上的应力。
应该理解的是，本申请的实施例的不同元件可以组合为形成本发明所想到的额外的设计。例如，在图26A和26B中所显示的隔膜锚定假体1400可以与就图20A-20C的假体900所显示的锚定结构相组合。
尽管在本发明中所披露的实施例特殊地描述为用于心脏的二尖瓣，但应该想到的是，这些实施例可以适合于用于其它心脏瓣膜。例如，锚定结构可以修改为在心脏内压靠在不同的几何形状上，而袋可以适合于不同形状的瓣膜，例如三尖瓣。
虽然就特别的实施例和应用描述了本发明，但基于本教示，在本领域中的普通技术人员可以在不偏离本发明的主旨或不超越本发明的范围的情况下，实施额外的实施例，并且进行额外的修改。因此，应该理解的是，附图和描述在这里作为例子提供以有助于理解本发明，而不应该用来限制其范围。

Claims (14)

1.一种用于治疗瓣膜反流的装置，其包括：
确定尺寸为至少部分地放置在瓣膜的小叶之间的接合部件，所述的接合部件具有扩张状态和缩小状态，并且具有大致上等于所述的小叶的连合处的长度；和
连接到所述的接合部件的锚定结构，所述的锚定结构具有确定尺寸为配合在递送导管内的压缩状态和确定尺寸为固定在邻近所述的瓣膜的腔的壁的至少部分上的扩张状态，
所述的接合部件包括柔性袋，所述的柔性袋包括布置在支撑结构上的柔性材料，所述的支撑结构确定尺寸为使得所述的柔性袋沿所述的连合处的长度延伸。
2.根据权利要求1所述的装置，其特征在于，所述的柔性材料是心包组织。
3.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括锚定丝。
4.根据权利要求3所述的装置，其特征在于，所述的锚定丝确定形状为固定成靠在左心房的壁上。
5.根据权利要求3所述的装置，其特征在于，所述的锚定丝确定形状为接触二尖瓣环。
6.根据权利要求1所述的装置，其特征在于，所述的锚定结构确定尺寸为大致上符合于左心房的一部分。
7.根据权利要求1所述的装置，其特征在于，所述的锚定结构可转动地连接到所述的接合部件。
8.根据权利要求1所述的装置，其特征在于，所述的锚定结构确定尺寸为固定在心房隔膜上。
9.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括支架部分。
10.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括圈。
11.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括多个环。
12.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括具有多个弯曲部分的丝。
13.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括锚定笼。
14.根据权利要求1所述的装置，其特征在于，所述的锚定结构包括具有确定尺寸为固定成靠在邻近所述的瓣膜的腔的壁的所述的部分上的扩张形状的第一锚定部件和具有确定尺寸为固定成靠在瓣膜环上的扩张形状的第二锚定部件。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9592118B2 (en) 2011-01-28 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US11850151B2 (en) 2019-07-15 2023-12-26 Evalve, Inc. Proximal element actuator fixation and release mechanisms

Families Citing this family (550)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
WO1999000059A1 (en) * 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
FR2768324B1 (fr) 1997-09-12 1999-12-10 Jacques Seguin Instrument chirurgical permettant, par voie percutanee, de fixer l'une a l'autre deux zones de tissu mou, normalement mutuellement distantes
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US7226467B2 (en) 1999-04-09 2007-06-05 Evalve, Inc. Fixation device delivery catheter, systems and methods of use
CA2620783C (en) 1999-04-09 2011-04-05 Evalve, Inc. Methods and apparatus for cardiac valve repair
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US7604646B2 (en) 1999-04-09 2009-10-20 Evalve, Inc. Locking mechanisms for fixation devices and methods of engaging tissue
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US10327743B2 (en) * 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US8216256B2 (en) * 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
EP1113497A3 (en) * 1999-12-29 2006-01-25 Texas Instruments Incorporated Semiconductor package with conductor impedance selected during assembly
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US8366769B2 (en) 2000-06-01 2013-02-05 Edwards Lifesciences Corporation Low-profile, pivotable heart valve sewing ring
US6409758B2 (en) * 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6575971B2 (en) * 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US7048754B2 (en) * 2002-03-01 2006-05-23 Evalve, Inc. Suture fasteners and methods of use
US6752828B2 (en) * 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US8172856B2 (en) 2002-08-02 2012-05-08 Cedars-Sinai Medical Center Methods and apparatus for atrioventricular valve repair
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
US6945957B2 (en) 2002-12-30 2005-09-20 Scimed Life Systems, Inc. Valve treatment catheter and methods
US10646229B2 (en) 2003-05-19 2020-05-12 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US20050075725A1 (en) 2003-10-02 2005-04-07 Rowe Stanton J. Implantable prosthetic valve with non-laminar flow
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US20090132035A1 (en) * 2004-02-27 2009-05-21 Roth Alex T Prosthetic Heart Valves, Support Structures and Systems and Methods for Implanting the Same
JP4975609B2 (ja) * 2004-02-27 2012-07-11 エーオーテックス， インコーポレイテッド 補綴心臓弁送達システムおよびその方法
US20070073387A1 (en) * 2004-02-27 2007-03-29 Forster David C Prosthetic Heart Valves, Support Structures And Systems And Methods For Implanting The Same
US20050228494A1 (en) * 2004-03-29 2005-10-13 Salvador Marquez Controlled separation heart valve frame
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7704277B2 (en) 2004-09-14 2010-04-27 Edwards Lifesciences Ag Device and method for treatment of heart valve regurgitation
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
CA2748617C (en) 2004-09-27 2014-09-23 Evalve, Inc. Methods and devices for tissue grasping and assessment
AU2004324043A1 (en) 2004-10-02 2006-04-20 Christoph Hans Huber Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
WO2006064490A1 (en) * 2004-12-15 2006-06-22 Mednua Limited A medical device suitable for use in treatment of a valve
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
WO2006078694A2 (en) 2005-01-21 2006-07-27 Mayo Foundation For Medical Education And Research Thorascopic heart valve repair method and apparatus
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
US7854755B2 (en) 2005-02-01 2010-12-21 Boston Scientific Scimed, Inc. Vascular catheter, system, and method
US8470028B2 (en) * 2005-02-07 2013-06-25 Evalve, Inc. Methods, systems and devices for cardiac valve repair
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
US7780722B2 (en) 2005-02-07 2010-08-24 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US20100298929A1 (en) * 2005-02-07 2010-11-25 Thornton Troy L Methods, systems and devices for cardiac valve repair
US7670368B2 (en) 2005-02-07 2010-03-02 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8574257B2 (en) * 2005-02-10 2013-11-05 Edwards Lifesciences Corporation System, device, and method for providing access in a cardiovascular environment
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US8608797B2 (en) 2005-03-17 2013-12-17 Valtech Cardio Ltd. Mitral valve treatment techniques
US7513909B2 (en) * 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
SE531468C2 (sv) 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
US20060247672A1 (en) * 2005-04-27 2006-11-02 Vidlund Robert M Devices and methods for pericardial access
EP2901967B1 (en) 2005-05-24 2019-10-02 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
WO2006130505A2 (en) 2005-05-27 2006-12-07 Arbor Surgical Technologies, Inc. Gasket with collar for prosthetic heart valves and methods for using them
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8951285B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor, anchoring system and methods of using the same
US7776084B2 (en) * 2005-07-13 2010-08-17 Edwards Lifesciences Corporation Prosthetic mitral heart valve having a contoured sewing ring
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
US8092525B2 (en) * 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
US8778017B2 (en) 2005-10-26 2014-07-15 Cardiosolutions, Inc. Safety for mitral valve implant
US8852270B2 (en) 2007-11-15 2014-10-07 Cardiosolutions, Inc. Implant delivery system and method
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
US9259317B2 (en) 2008-06-13 2016-02-16 Cardiosolutions, Inc. System and method for implanting a heart implant
US8216302B2 (en) 2005-10-26 2012-07-10 Cardiosolutions, Inc. Implant delivery and deployment system and method
US7785366B2 (en) * 2005-10-26 2010-08-31 Maurer Christopher W Mitral spacer
US7799038B2 (en) 2006-01-20 2010-09-21 Boston Scientific Scimed, Inc. Translumenal apparatus, system, and method
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
US7749249B2 (en) * 2006-02-21 2010-07-06 Kardium Inc. Method and device for closing holes in tissue
US7749266B2 (en) * 2006-02-27 2010-07-06 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8147541B2 (en) * 2006-02-27 2012-04-03 Aortx, Inc. Methods and devices for delivery of prosthetic heart valves and other prosthetics
US8414568B2 (en) 2006-04-04 2013-04-09 The Spectranetics Corporation Laser-assisted guidewire having a variable stiffness shaft
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
US8021161B2 (en) * 2006-05-01 2011-09-20 Edwards Lifesciences Corporation Simulated heart valve root for training and testing
US8932348B2 (en) 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function
US8585594B2 (en) * 2006-05-24 2013-11-19 Phoenix Biomedical, Inc. Methods of assessing inner surfaces of body lumens or organs
AU2013245451A1 (en) * 2006-06-01 2013-10-31 Edwards Lifesciences Corporation Prosthetic insert for improving heart valve function
EP3241525B2 (en) 2006-06-01 2022-06-08 Edwards Lifesciences Corporation Prosthetic insert for use with a mitral valve
US20070287879A1 (en) * 2006-06-13 2007-12-13 Daniel Gelbart Mechanical means for controlling blood pressure
EP2035723A4 (en) * 2006-06-20 2011-11-30 Aortx Inc TORQUE SHAFT AND TORQUE DRIVE
CA2657442A1 (en) * 2006-06-20 2007-12-27 Aortx, Inc. Prosthetic heart valves, support structures and systems and methods for implanting the same
JP2009540954A (ja) * 2006-06-20 2009-11-26 エーオーテックス， インコーポレイテッド 補綴弁移植部位の調製技術
AU2007260951A1 (en) * 2006-06-21 2007-12-27 Aortx, Inc. Prosthetic valve implantation systems
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US20080097585A1 (en) * 2006-06-30 2008-04-24 Richard Sisken Valve repair systems and methods
US20080126131A1 (en) * 2006-07-17 2008-05-29 Walgreen Co. Predictive Modeling And Risk Stratification Of A Medication Therapy Regimen
US9408607B2 (en) 2009-07-02 2016-08-09 Edwards Lifesciences Cardiaq Llc Surgical implant devices and methods for their manufacture and use
AU2007281553B2 (en) 2006-07-31 2013-09-19 Edwards Lifesciences Cardiaq Llc Sealable endovascular implants and methods for their use
US9585743B2 (en) 2006-07-31 2017-03-07 Edwards Lifesciences Cardiaq Llc Surgical implant devices and methods for their manufacture and use
US20080033541A1 (en) * 2006-08-02 2008-02-07 Daniel Gelbart Artificial mitral valve
US7837610B2 (en) 2006-08-02 2010-11-23 Kardium Inc. System for improving diastolic dysfunction
CN101511304A (zh) * 2006-09-06 2009-08-19 奥尔特克斯公司 人工心脏瓣膜、系统和移植方法
CA2998123C (en) 2006-09-08 2021-03-02 Edwards Lifesciences Corporation Integrated heart valve delivery system
US9974653B2 (en) 2006-12-05 2018-05-22 Valtech Cardio, Ltd. Implantation of repair devices in the heart
WO2010004546A1 (en) 2008-06-16 2010-01-14 Valtech Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US8236045B2 (en) 2006-12-22 2012-08-07 Edwards Lifesciences Corporation Implantable prosthetic valve assembly and method of making the same
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
WO2008101113A1 (en) * 2007-02-14 2008-08-21 Edwards Lifesciences Corporation Suture and method for repairing heart
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US8480730B2 (en) 2007-05-14 2013-07-09 Cardiosolutions, Inc. Solid construct mitral spacer
US8828079B2 (en) 2007-07-26 2014-09-09 Boston Scientific Scimed, Inc. Circulatory valve, system and method
US9566178B2 (en) 2010-06-24 2017-02-14 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US20090076597A1 (en) * 2007-09-19 2009-03-19 Jonathan Micheal Dahlgren System for mechanical adjustment of medical implants
JP5357167B2 (ja) 2007-10-18 2013-12-04 ネオコード インコーポレイテッド 侵襲性を最小限に抑えた拍動する心臓内の弁尖を修復するための器具
US8343029B2 (en) * 2007-10-24 2013-01-01 Circulite, Inc. Transseptal cannula, tip, delivery system, and method
US8821366B2 (en) 2007-10-24 2014-09-02 Circulite, Inc. Transseptal cannula, tip, delivery system, and method
US8597347B2 (en) * 2007-11-15 2013-12-03 Cardiosolutions, Inc. Heart regurgitation method and apparatus
EP4079261A1 (en) 2007-12-14 2022-10-26 Edwards Lifesciences Corporation Leaflet attachment frame for a prosthetic valve
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
WO2009092782A1 (en) 2008-01-25 2009-07-30 Jenavalve Technology Inc. Medical apparatus for the therapeutic treatment of an insufficient cardiac valve
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
CA2961051C (en) 2008-02-29 2020-01-14 Edwards Lifesciences Corporation Expandable member for deploying a prosthetic device
US8382829B1 (en) 2008-03-10 2013-02-26 Mitralign, Inc. Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
US9421065B2 (en) 2008-04-02 2016-08-23 The Spectranetics Corporation Liquid light-guide catheter with optically diverging tip
US8979828B2 (en) 2008-07-21 2015-03-17 The Spectranetics Corporation Tapered liquid light guide
US20100121435A1 (en) 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Percutaneous transvalvular intrannular band for mitral valve repair
US11083579B2 (en) 2008-04-16 2021-08-10 Heart Repair Technologies, Inc. Transvalvular intraanular band and chordae cutting for ischemic and dilated cardiomyopathy
US20100121437A1 (en) 2008-04-16 2010-05-13 Cardiovascular Technologies, Llc Transvalvular intraannular band and chordae cutting for ischemic and dilated cardiomyopathy
US8262725B2 (en) * 2008-04-16 2012-09-11 Cardiovascular Technologies, Llc Transvalvular intraannular band for valve repair
US11013599B2 (en) 2008-04-16 2021-05-25 Heart Repair Technologies, Inc. Percutaneous transvalvular intraannular band for mitral valve repair
US10456259B2 (en) 2008-04-16 2019-10-29 Heart Repair Technologies, Inc. Transvalvular intraannular band for mitral valve repair
US20100131057A1 (en) 2008-04-16 2010-05-27 Cardiovascular Technologies, Llc Transvalvular intraannular band for aortic valve repair
US8323336B2 (en) * 2008-04-23 2012-12-04 Medtronic, Inc. Prosthetic heart valve devices and methods of valve replacement
US9173737B2 (en) * 2008-04-23 2015-11-03 Medtronic, Inc. Stented heart valve devices
US20090276040A1 (en) 2008-05-01 2009-11-05 Edwards Lifesciences Corporation Device and method for replacing mitral valve
US9061119B2 (en) 2008-05-09 2015-06-23 Edwards Lifesciences Corporation Low profile delivery system for transcatheter heart valve
US20090287304A1 (en) 2008-05-13 2009-11-19 Kardium Inc. Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve
WO2009149462A2 (en) 2008-06-06 2009-12-10 Edwards Lifesciences Corporation Low profile transcatheter heart valve
US8591460B2 (en) 2008-06-13 2013-11-26 Cardiosolutions, Inc. Steerable catheter and dilator and system and method for implanting a heart implant
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
WO2010006627A1 (en) * 2008-07-17 2010-01-21 Nvt Ag Cardiac valve prosthesis system
US8652202B2 (en) 2008-08-22 2014-02-18 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
EP2367505B1 (en) 2008-09-29 2020-08-12 Edwards Lifesciences CardiAQ LLC Heart valve
CA2739275C (en) 2008-10-01 2017-01-17 Impala, Inc. Delivery system for vascular implant
US8690936B2 (en) 2008-10-10 2014-04-08 Edwards Lifesciences Corporation Expandable sheath for introducing an endovascular delivery device into a body
US8449625B2 (en) * 2009-10-27 2013-05-28 Edwards Lifesciences Corporation Methods of measuring heart valve annuluses for valve replacement
CA2743719C (en) 2008-11-25 2019-03-19 Edwards Lifesciences Corporation Apparatus and method for in situ expansion of prosthetic device
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US8147542B2 (en) 2008-12-22 2012-04-03 Valtech Cardio, Ltd. Adjustable repair chords and spool mechanism therefor
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
CN102341063B (zh) 2008-12-22 2015-11-25 瓦尔泰克卡迪欧有限公司 可调瓣环成形装置及其调节机构
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
US8241351B2 (en) 2008-12-22 2012-08-14 Valtech Cardio, Ltd. Adjustable partial annuloplasty ring and mechanism therefor
US8353956B2 (en) 2009-02-17 2013-01-15 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
JP2012520716A (ja) * 2009-03-17 2012-09-10 ミトラシスト メディカル リミテッド 折りたためる弁を持つ人工弁及びその送出方法
US9980818B2 (en) 2009-03-31 2018-05-29 Edwards Lifesciences Corporation Prosthetic heart valve system with positioning markers
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
US8475522B2 (en) 2009-07-14 2013-07-02 Edwards Lifesciences Corporation Transapical delivery system for heart valves
EP3042615A1 (en) 2009-09-15 2016-07-13 Evalve, Inc. Methods, systems and devices for cardiac valve repair
US20110077733A1 (en) * 2009-09-25 2011-03-31 Edwards Lifesciences Corporation Leaflet contacting apparatus and method
EP2482749B1 (en) 2009-10-01 2017-08-30 Kardium Inc. Kit for constricting tissue or a bodily orifice, for example, a mitral valve
US10098737B2 (en) 2009-10-29 2018-10-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
EP2506777B1 (en) 2009-12-02 2020-11-25 Valtech Cardio, Ltd. Combination of spool assembly coupled to a helical anchor and delivery tool for implantation thereof
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US9072603B2 (en) * 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US8795354B2 (en) 2010-03-05 2014-08-05 Edwards Lifesciences Corporation Low-profile heart valve and delivery system
US8974475B2 (en) * 2010-04-30 2015-03-10 Medtronic, Inc. Methods and devices for cardiac valve repair or replacement
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CN102883684B (zh) 2010-05-10 2015-04-08 爱德华兹生命科学公司 人工心脏瓣膜
US9554901B2 (en) 2010-05-12 2017-01-31 Edwards Lifesciences Corporation Low gradient prosthetic heart valve
JP2013526388A (ja) 2010-05-25 2013-06-24 イエナバルブ テクノロジー インク 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ
US9050066B2 (en) 2010-06-07 2015-06-09 Kardium Inc. Closing openings in anatomical tissue
JP5848345B2 (ja) 2010-07-09 2016-01-27 ハイライフ エスエーエス 経カテーテル式房室弁人工器官
US9526483B2 (en) 2010-07-15 2016-12-27 Medtronic Vascular Galway Apical closure system
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
WO2012012761A2 (en) 2010-07-23 2012-01-26 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9370418B2 (en) 2010-09-10 2016-06-21 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
US9125741B2 (en) 2010-09-10 2015-09-08 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
WO2012040643A2 (en) * 2010-09-23 2012-03-29 Colibri Heart Valve Llc Percutaneously deliverable heart or blood vessel valve with frame having abluminally situated tissue membrane
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
US8940002B2 (en) 2010-09-30 2015-01-27 Kardium Inc. Tissue anchor system
DE202011111128U1 (de) 2010-10-05 2020-05-27 Edwards Lifesciences Corporation Prothetische Herzklappe
CA2822381C (en) 2010-12-23 2019-04-02 Foundry Newco Xii, Inc. System for mitral valve repair and replacement
CN103347464B (zh) 2010-12-29 2016-02-03 尼奥绰德有限公司 微创修复搏动心脏瓣膜小叶的可替换系统
EP2667824A4 (en) 2011-01-25 2017-11-01 Emory University Devices and methods for surgical and percutaneous repair of heart valve lesions
EP2478868A1 (en) 2011-01-25 2012-07-25 The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Implant device
US8845717B2 (en) 2011-01-28 2014-09-30 Middle Park Medical, Inc. Coaptation enhancement implant, system, and method
US9155619B2 (en) 2011-02-25 2015-10-13 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
US11083870B2 (en) 2011-04-11 2021-08-10 The Spectranetics Corporation Hypotube based support catheter
EP2696929A1 (en) 2011-04-11 2014-02-19 The Spectranetics Corporation Needle and guidewire holder
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US8945209B2 (en) 2011-05-20 2015-02-03 Edwards Lifesciences Corporation Encapsulated heart valve
US9289282B2 (en) 2011-05-31 2016-03-22 Edwards Lifesciences Corporation System and method for treating valve insufficiency or vessel dilatation
CA2837206C (en) 2011-06-01 2019-09-24 John Zentgraf Minimally invasive repair of heart valve leaflets
US9011523B2 (en) 2011-06-20 2015-04-21 Jacques Seguin Prosthetic leaflet assembly for repairing a defective cardiac valve and methods of using the same
CN107496054B (zh) 2011-06-21 2020-03-03 托尔福公司 人工心脏瓣膜装置及相关系统和方法
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US9918840B2 (en) 2011-06-23 2018-03-20 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US9119716B2 (en) 2011-07-27 2015-09-01 Edwards Lifesciences Corporation Delivery systems for prosthetic heart valve
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9510948B2 (en) 2011-09-09 2016-12-06 Emory University Systems, devices and methods for repair of heart valve lesions
US9011468B2 (en) * 2011-09-13 2015-04-21 Abbott Cardiovascular Systems Inc. Independent gripper
US8945177B2 (en) * 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
EP3943047B1 (en) 2011-10-19 2023-08-30 Twelve, Inc. Device for heart valve replacement
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
CN111000663B (zh) 2011-10-19 2022-04-15 托尔福公司 人工心脏瓣膜装置、人工二尖瓣和相关系统及方法
US9827093B2 (en) 2011-10-21 2017-11-28 Edwards Lifesciences Cardiaq Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
EP3970627B1 (en) 2011-11-08 2023-12-20 Edwards Lifesciences Innovation (Israel) Ltd. Controlled steering functionality for implant-delivery tool
US9445893B2 (en) * 2011-11-21 2016-09-20 Mor Research Applications Ltd. Device for placement in the tricuspid annulus
CA3201836A1 (en) 2011-12-09 2013-06-13 Edwards Lifesciences Corporation Prosthetic heart valve having improved commissure supports
US8652145B2 (en) 2011-12-14 2014-02-18 Edwards Lifesciences Corporation System and method for crimping a prosthetic valve
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
WO2013096541A1 (en) 2011-12-21 2013-06-27 The Trustees Of The University Of Pennsylvania Platforms for mitral valve replacement
CA2865013C (en) 2012-02-22 2020-12-15 Syntheon Cardiology, Llc Actively controllable stent, stent graft, heart valve and method of controlling same
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9101467B2 (en) 2012-03-30 2015-08-11 Medtronic CV Luxembourg S.a.r.l. Valve prosthesis
US9414823B2 (en) 2012-04-25 2016-08-16 Medtronic Ventor Technologies Ltd. Hole-closure device
WO2013173587A1 (en) * 2012-05-16 2013-11-21 Edwards Lifesciences Corporation Devices and methods for reducing cardiac valve regurgitation
US9474605B2 (en) 2012-05-16 2016-10-25 Edwards Lifesciences Corporation Devices and methods for reducing cardiac valve regurgitation
WO2013173618A2 (en) 2012-05-16 2013-11-21 Edwards Lifesciences Corporation Systems and methods for placing a coapting member between valvular leaflets
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
EP2900150B1 (en) 2012-09-29 2018-04-18 Mitralign, Inc. Plication lock delivery system
US9226823B2 (en) 2012-10-23 2016-01-05 Medtronic, Inc. Valve prosthesis
US9949828B2 (en) 2012-10-23 2018-04-24 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
WO2014064695A2 (en) 2012-10-23 2014-05-01 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
ES2931210T3 (es) 2012-11-21 2022-12-27 Edwards Lifesciences Corp Mecanismos de retención para válvulas cardiacas protésicas
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
EP2943132B1 (en) 2013-01-09 2018-03-28 4Tech Inc. Soft tissue anchors
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
WO2014114797A1 (en) * 2013-01-25 2014-07-31 Medtentia International Ltd Oy Temporary atrium support device
CN105073067B (zh) * 2013-01-25 2017-06-20 梅德坦提亚国际有限公司 用于帮助选择瓣环成形植入物的医疗设备
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US9168129B2 (en) 2013-02-12 2015-10-27 Edwards Lifesciences Corporation Artificial heart valve with scalloped frame design
US9724084B2 (en) 2013-02-26 2017-08-08 Mitralign, Inc. Devices and methods for percutaneous tricuspid valve repair
WO2014138482A1 (en) 2013-03-07 2014-09-12 Cedars-Sinai Medical Center Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis
WO2014138284A1 (en) 2013-03-07 2014-09-12 Cedars-Sinai Medical Center Catheter based apical approach heart prostheses delivery system
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
WO2014141239A1 (en) 2013-03-14 2014-09-18 4Tech Inc. Stent with tether interface
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
US11007058B2 (en) 2013-03-15 2021-05-18 Edwards Lifesciences Corporation Valved aortic conduits
SG11201506352SA (en) 2013-03-15 2015-09-29 Edwards Lifesciences Corp Valved aortic conduits
WO2014144247A1 (en) 2013-03-15 2014-09-18 Arash Kheradvar Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
EP2968847B1 (en) 2013-03-15 2023-03-08 Edwards Lifesciences Corporation Translation catheter systems
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
EP2994072B1 (en) 2013-05-09 2022-01-19 Mitrassist Medical Ltd. Heart valve assistive prosthesis
CA2908342C (en) 2013-05-20 2021-11-30 Edwards Lifesciences Corporation Prosthetic heart valve delivery apparatus
CN108294846A (zh) 2013-05-20 2018-07-20 托尔福公司 可植入心脏瓣膜装置、二尖瓣修复装置以及相关系统和方法
US9468527B2 (en) 2013-06-12 2016-10-18 Edwards Lifesciences Corporation Cardiac implant with integrated suture fasteners
AU2014277902A1 (en) 2013-06-14 2016-02-04 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
SG10202103500PA (en) 2013-08-12 2021-05-28 Mitral Valve Tech Sarl Apparatus and methods for implanting a replacement heart valve
JP6328242B2 (ja) 2013-08-14 2018-05-23 マイトラル・ヴァルヴ・テクノロジーズ・エス・アー・エール・エル 心臓弁置換のためのシステム
US10052198B2 (en) 2013-08-14 2018-08-21 Mitral Valve Technologies Sarl Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device
US9919137B2 (en) 2013-08-28 2018-03-20 Edwards Lifesciences Corporation Integrated balloon catheter inflation system
CN105491978A (zh) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 用于假体瓣膜的径向可折叠框架及其制造方法
US10070857B2 (en) 2013-08-31 2018-09-11 Mitralign, Inc. Devices and methods for locating and implanting tissue anchors at mitral valve commissure
SG11201508895RA (en) 2013-09-20 2015-11-27 Edwards Lifesciences Corp Heart valves with increased effective orifice area
WO2015059699A2 (en) 2013-10-23 2015-04-30 Valtech Cardio, Ltd. Anchor magazine
US10166098B2 (en) 2013-10-25 2019-01-01 Middle Peak Medical, Inc. Systems and methods for transcatheter treatment of valve regurgitation
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US20150122687A1 (en) 2013-11-06 2015-05-07 Edwards Lifesciences Corporation Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage
CR20160240A (es) 2013-11-11 2016-08-04 Edwards Lifesciences Cardiaq Llc Sistemas y métodos para la manufactura del marco de una cánula
US9622863B2 (en) 2013-11-22 2017-04-18 Edwards Lifesciences Corporation Aortic insufficiency repair device and method
DE102013017993A1 (de) * 2013-11-29 2015-06-03 Universität Duisburg-Essen Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
US10098734B2 (en) 2013-12-05 2018-10-16 Edwards Lifesciences Corporation Prosthetic heart valve and delivery apparatus
US9901444B2 (en) 2013-12-17 2018-02-27 Edwards Lifesciences Corporation Inverted valve structure
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
PT3107500T (pt) 2014-02-18 2021-12-24 Edwards Lifesciences Corp Estrutura de comissura flexível
EP3107498B1 (en) 2014-02-21 2020-09-30 Mitral Valve Technologies Sàrl Prosthetic mitral valve with anchoring device
US9572666B2 (en) 2014-03-17 2017-02-21 Evalve, Inc. Mitral valve fixation device removal devices and methods
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9549816B2 (en) 2014-04-03 2017-01-24 Edwards Lifesciences Corporation Method for manufacturing high durability heart valve
US10154904B2 (en) 2014-04-28 2018-12-18 Edwards Lifesciences Corporation Intravascular introducer devices
US9585752B2 (en) 2014-04-30 2017-03-07 Edwards Lifesciences Corporation Holder and deployment system for surgical heart valves
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
CA2958061A1 (en) 2014-06-18 2015-12-23 Middle Peak Medical, Inc. Mitral valve implants for the treatment of valvular regurgitation
CN106573129B (zh) 2014-06-19 2019-09-24 4科技有限公司 心脏组织束紧
CA2914094C (en) 2014-06-20 2021-01-05 Edwards Lifesciences Corporation Surgical heart valves identifiable post-implant
USD867594S1 (en) 2015-06-19 2019-11-19 Edwards Lifesciences Corporation Prosthetic heart valve
EP3160396B1 (en) 2014-06-24 2022-03-23 Polares Medical Inc. Systems for anchoring an implant
CN104042359B (zh) 2014-06-30 2017-01-04 江苏大学 一种修复二尖瓣反流的自适应定位的二尖瓣闭合板阻塞体
CN104055605B (zh) * 2014-07-07 2016-06-01 宁波健世生物科技有限公司 一种用于阻止瓣膜反流的假体
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US10799359B2 (en) 2014-09-10 2020-10-13 Cedars-Sinai Medical Center Method and apparatus for percutaneous delivery and deployment of a cardiac valve prosthesis
US10016272B2 (en) 2014-09-12 2018-07-10 Mitral Valve Technologies Sarl Mitral repair and replacement devices and methods
ES2676060T3 (es) * 2014-09-26 2018-07-16 Nvt Ag Dispositivo implantable para el tratamiento de la regurgitación de la válvula mitral
WO2016050751A1 (en) 2014-09-29 2016-04-07 Martin Quinn A heart valve treatment device and method
EP3206629B1 (en) 2014-10-14 2021-07-14 Valtech Cardio, Ltd. Apparatus for heart valve leaflet restraining
FR3027212A1 (fr) 2014-10-16 2016-04-22 Seguin Jacques Implant intervalvulaire pour valve mitrale
US10758265B2 (en) 2014-11-14 2020-09-01 Cedars-Sinai Medical Center Cardiovascular access and device delivery system
CN107106296A (zh) * 2014-11-17 2017-08-29 二尖瓣辅助治疗有限公司 用于心脏瓣膜的辅助装置
US20160144156A1 (en) 2014-11-20 2016-05-26 Edwards Lifesciences Corporation Inflatable device with etched modifications
US9907547B2 (en) 2014-12-02 2018-03-06 4Tech Inc. Off-center tissue anchors
WO2016090308A1 (en) 2014-12-04 2016-06-09 Edwards Lifesciences Corporation Percutaneous clip for repairing a heart valve
CR20170245A (es) 2014-12-05 2017-09-14 Edwards Lifesciences Corp Cateter dirigible con cable de tracción
US9517131B2 (en) 2014-12-12 2016-12-13 Than Nguyen Cardiac valve repair device
WO2016098104A2 (en) 2014-12-14 2016-06-23 Mor Research Applications Ltd. Prosthetic valve and deployment system
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
EP3253333B1 (en) 2015-02-05 2024-04-03 Cardiovalve Ltd Prosthetic valve with axially-sliding frames
US10231834B2 (en) 2015-02-09 2019-03-19 Edwards Lifesciences Corporation Low profile transseptal catheter and implant system for minimally invasive valve procedure
US10105226B2 (en) 2015-02-10 2018-10-23 Edwards Lifesciences Corporation Offset cardiac leaflet coaptation element
US10039637B2 (en) 2015-02-11 2018-08-07 Edwards Lifesciences Corporation Heart valve docking devices and implanting methods
US20160256269A1 (en) 2015-03-05 2016-09-08 Mitralign, Inc. Devices for treating paravalvular leakage and methods use thereof
US10231827B2 (en) 2015-03-18 2019-03-19 Medtronic Vascular, Inc. Valve prostheses having an integral centering mechanism and methods of use thereof
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
US10792471B2 (en) 2015-04-10 2020-10-06 Edwards Lifesciences Corporation Expandable sheath
US10327896B2 (en) 2015-04-10 2019-06-25 Edwards Lifesciences Corporation Expandable sheath with elastomeric cross sectional portions
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10232564B2 (en) 2015-04-29 2019-03-19 Edwards Lifesciences Corporation Laminated sealing member for prosthetic heart valve
CN114515173A (zh) 2015-04-30 2022-05-20 瓦尔泰克卡迪欧有限公司 瓣膜成形术技术
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US9629720B2 (en) 2015-05-04 2017-04-25 Jacques Seguin Apparatus and methods for treating cardiac valve regurgitation
DE102015005934A1 (de) * 2015-05-12 2016-11-17 Coramaze Technologies Gmbh Implantierbare Vorrichtung zur Verbesserung oder Behebung einer Herzklappeninsuffizienz
EP3294219B1 (en) * 2015-05-14 2020-05-13 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US10376673B2 (en) 2015-06-19 2019-08-13 Evalve, Inc. Catheter guiding system and methods
US10238494B2 (en) 2015-06-29 2019-03-26 Evalve, Inc. Self-aligning radiopaque ring
CR20170597A (es) 2015-07-02 2018-04-20 Edwards Lifesciences Corp Válvulas cardíacas hibridas integradas
WO2017004369A1 (en) 2015-07-02 2017-01-05 Edwards Lifesciences Corporation Hybrid heart valves adapted for post-implant expansion
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US10667815B2 (en) 2015-07-21 2020-06-02 Evalve, Inc. Tissue grasping devices and related methods
WO2017015632A1 (en) 2015-07-23 2017-01-26 Cedars-Sinai Medical Center Device for securing heart valve leaflets
US10413408B2 (en) 2015-08-06 2019-09-17 Evalve, Inc. Delivery catheter systems, methods, and devices
US10179046B2 (en) 2015-08-14 2019-01-15 Edwards Lifesciences Corporation Gripping and pushing device for medical instrument
US11026788B2 (en) 2015-08-20 2021-06-08 Edwards Lifesciences Corporation Loader and retriever for transcatheter heart valve, and methods of crimping transcatheter heart valve
EP3337428A1 (en) 2015-08-21 2018-06-27 Twelve Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
EP3344158B1 (en) 2015-09-02 2023-03-01 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
US10588744B2 (en) 2015-09-04 2020-03-17 Edwards Lifesciences Corporation Delivery system for prosthetic heart valve
US10080653B2 (en) 2015-09-10 2018-09-25 Edwards Lifesciences Corporation Limited expansion heart valve
US10314703B2 (en) 2015-09-21 2019-06-11 Edwards Lifesciences Corporation Cylindrical implant and balloon
WO2017059406A1 (en) 2015-10-01 2017-04-06 Neochord, Inc. Ringless web for repair of heart valves
US10238495B2 (en) 2015-10-09 2019-03-26 Evalve, Inc. Delivery catheter handle and methods of use
US9872765B2 (en) * 2015-10-12 2018-01-23 Venus Medtech (Hangzhou) Inc Mitral valve assembly
US10350067B2 (en) 2015-10-26 2019-07-16 Edwards Lifesciences Corporation Implant delivery capsule
US11259920B2 (en) 2015-11-03 2022-03-01 Edwards Lifesciences Corporation Adapter for prosthesis delivery device and methods of use
US10376364B2 (en) 2015-11-10 2019-08-13 Edwards Lifesciences Corporation Implant delivery capsule
US10470876B2 (en) 2015-11-10 2019-11-12 Edwards Lifesciences Corporation Transcatheter heart valve for replacing natural mitral valve
US10321996B2 (en) 2015-11-11 2019-06-18 Edwards Lifesciences Corporation Prosthetic valve delivery apparatus having clutch mechanism
US10265169B2 (en) 2015-11-23 2019-04-23 Edwards Lifesciences Corporation Apparatus for controlled heart valve delivery
US11033387B2 (en) 2015-11-23 2021-06-15 Edwards Lifesciences Corporation Methods for controlled heart valve delivery
US10583007B2 (en) 2015-12-02 2020-03-10 Edwards Lifesciences Corporation Suture deployment of prosthetic heart valve
US10357351B2 (en) 2015-12-04 2019-07-23 Edwards Lifesciences Corporation Storage assembly for prosthetic valve
WO2017117370A2 (en) 2015-12-30 2017-07-06 Mitralign, Inc. System and method for reducing tricuspid regurgitation
US10751182B2 (en) 2015-12-30 2020-08-25 Edwards Lifesciences Corporation System and method for reshaping right heart
US11833034B2 (en) 2016-01-13 2023-12-05 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US10433952B2 (en) 2016-01-29 2019-10-08 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US10179043B2 (en) 2016-02-12 2019-01-15 Edwards Lifesciences Corporation Prosthetic heart valve having multi-level sealing member
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
ES2964770T3 (es) * 2016-02-29 2024-04-09 Coramaze Tech Gmbh Implante cardíaco
US10667904B2 (en) 2016-03-08 2020-06-02 Edwards Lifesciences Corporation Valve implant with integrated sensor and transmitter
US10779941B2 (en) 2016-03-08 2020-09-22 Edwards Lifesciences Corporation Delivery cylinder for prosthetic implant
US11219746B2 (en) 2016-03-21 2022-01-11 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799676B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799677B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10835714B2 (en) 2016-03-21 2020-11-17 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
US10799675B2 (en) 2016-03-21 2020-10-13 Edwards Lifesciences Corporation Cam controlled multi-direction steerable handles
CA3216740A1 (en) 2016-03-24 2017-09-28 Edwards Lifesciences Corporation Delivery system for prosthetic heart valve
CN105726072B (zh) * 2016-04-14 2018-02-27 江苏大学 一种经心尖植入的二尖瓣气囊闭合板阻塞体及植入方法
WO2017189276A1 (en) 2016-04-29 2017-11-02 Medtronic Vascular Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
WO2017191549A1 (en) * 2016-05-05 2017-11-09 LAINCHBURY, John George Device for the treatment of mitral valve prolapse
EP3454795B1 (en) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system
US10456245B2 (en) 2016-05-16 2019-10-29 Edwards Lifesciences Corporation System and method for applying material to a stent
CN109414319B (zh) * 2016-05-25 2021-08-10 克拉玛泽技术有限公司 心脏植入物
US10702274B2 (en) 2016-05-26 2020-07-07 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
US10973638B2 (en) 2016-07-07 2021-04-13 Edwards Lifesciences Corporation Device and method for treating vascular insufficiency
US10856981B2 (en) 2016-07-08 2020-12-08 Edwards Lifesciences Corporation Expandable sheath and methods of using the same
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
US11096781B2 (en) 2016-08-01 2021-08-24 Edwards Lifesciences Corporation Prosthetic heart valve
CN114587712A (zh) 2016-08-10 2022-06-07 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
US10828152B2 (en) * 2016-08-11 2020-11-10 4C Medical Technologies, Inc. Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function
US10357361B2 (en) 2016-09-15 2019-07-23 Edwards Lifesciences Corporation Heart valve pinch devices and delivery systems
WO2018050202A1 (en) * 2016-09-16 2018-03-22 Coramaze Technologies Gmbh Heart implant
WO2018050203A1 (en) * 2016-09-16 2018-03-22 Coramaze Technologies Gmbh Heart implant
US10575944B2 (en) 2016-09-22 2020-03-03 Edwards Lifesciences Corporation Prosthetic heart valve with reduced stitching
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
WO2018077371A1 (en) * 2016-10-28 2018-05-03 Coramaze Technologies Gmbh Heart implant
US10653862B2 (en) 2016-11-07 2020-05-19 Edwards Lifesciences Corporation Apparatus for the introduction and manipulation of multiple telescoping catheters
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
US10973631B2 (en) 2016-11-17 2021-04-13 Edwards Lifesciences Corporation Crimping accessory device for a prosthetic valve
US10463484B2 (en) 2016-11-17 2019-11-05 Edwards Lifesciences Corporation Prosthetic heart valve having leaflet inflow below frame
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US10603165B2 (en) 2016-12-06 2020-03-31 Edwards Lifesciences Corporation Mechanically expanding heart valve and delivery apparatus therefor
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues
US10314586B2 (en) 2016-12-13 2019-06-11 Evalve, Inc. Rotatable device and method for fixing tricuspid valve tissue
USD846122S1 (en) 2016-12-16 2019-04-16 Edwards Lifesciences Corporation Heart valve sizer
HUE061376T2 (hu) 2016-12-16 2023-06-28 Edwards Lifesciences Corp Behelyezõ rendszerek és mûszerek rögzítõeszköz bejuttatására egy billentyûprotézishez
EP3906893A1 (en) 2016-12-20 2021-11-10 Edwards Lifesciences Corporation Systems and mechanisms for deploying a docking device for a replacement heart valve
CN115137529A (zh) 2016-12-21 2022-10-04 特里弗洛心血管公司 心脏瓣膜支撑装置及用于制造和使用该装置的方法
JP2020501842A (ja) 2016-12-22 2020-01-23 ハート・リペアー・テクノロジーズ・インコーポレーテッド インプラントを心臓弁輪に固定する経皮的送達システム
WO2018129320A1 (en) * 2017-01-05 2018-07-12 Harmony Development Group, Inc. Expandable device for capturing regurgitant jet, volume, and force to effect ventricular function and remodeling
US10905554B2 (en) 2017-01-05 2021-02-02 Edwards Lifesciences Corporation Heart valve coaptation device
WO2018131042A1 (en) 2017-01-11 2018-07-19 Mitrassist Medical Ltd. Heart valve prosthesis
US11013600B2 (en) 2017-01-23 2021-05-25 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11185406B2 (en) 2017-01-23 2021-11-30 Edwards Lifesciences Corporation Covered prosthetic heart valve
US11654023B2 (en) 2017-01-23 2023-05-23 Edwards Lifesciences Corporation Covered prosthetic heart valve
US10561495B2 (en) 2017-01-24 2020-02-18 4C Medical Technologies, Inc. Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve
US11439501B2 (en) 2017-01-25 2022-09-13 Cedars-Sinai Medical Center Device for securing heart valve leaflets
CN110392557A (zh) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 心脏瓣膜模拟
CN109310497B (zh) * 2017-02-07 2022-02-01 上海甲悦医疗器械有限公司 用于治疗三尖瓣反流的装置
EP3372198B1 (en) * 2017-03-06 2019-06-19 AVVie GmbH Implant for improving coaptation of an atrioventricular valve
US10653524B2 (en) 2017-03-13 2020-05-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US10478303B2 (en) 2017-03-13 2019-11-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
CN110913801B (zh) 2017-03-13 2022-04-15 宝来瑞斯医疗有限公司 用于治疗心脏的心脏瓣膜的不良对合的对合辅助元件及用于输送其的系统
US10213306B2 (en) 2017-03-31 2019-02-26 Neochord, Inc. Minimally invasive heart valve repair in a beating heart
US10463485B2 (en) 2017-04-06 2019-11-05 Edwards Lifesciences Corporation Prosthetic valve holders with automatic deploying mechanisms
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
IL269799B2 (en) 2017-04-18 2023-10-01 Edwards Lifesciences Corp Devices for sealing heart valves and devices for their conduction
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US11224511B2 (en) 2017-04-18 2022-01-18 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US10973634B2 (en) 2017-04-26 2021-04-13 Edwards Lifesciences Corporation Delivery apparatus for a prosthetic heart valve
US10799312B2 (en) 2017-04-28 2020-10-13 Edwards Lifesciences Corporation Medical device stabilizing apparatus and method of use
CA3060663C (en) 2017-04-28 2024-03-26 Edwards Lifesciences Corporation Prosthetic heart valve with collapsible holder
US10959846B2 (en) 2017-05-10 2021-03-30 Edwards Lifesciences Corporation Mitral valve spacer device
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10842619B2 (en) 2017-05-12 2020-11-24 Edwards Lifesciences Corporation Prosthetic heart valve docking assembly
WO2018209313A1 (en) 2017-05-12 2018-11-15 Evalve, Inc. Long arm valve repair clip
US11135056B2 (en) 2017-05-15 2021-10-05 Edwards Lifesciences Corporation Devices and methods of commissure formation for prosthetic heart valve
EP3630013A4 (en) 2017-05-22 2020-06-17 Edwards Lifesciences Corporation VALVE ANCHORING DEVICE AND INSTALLATION METHOD
WO2018217921A1 (en) 2017-05-23 2018-11-29 Harmony Development Group, Inc. Tethered implantable device having a vortical intracardiac velocity adjusting balloon
US20210401571A9 (en) 2017-05-31 2021-12-30 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10869759B2 (en) 2017-06-05 2020-12-22 Edwards Lifesciences Corporation Mechanically expandable heart valve
US11026785B2 (en) 2017-06-05 2021-06-08 Edwards Lifesciences Corporation Mechanically expandable heart valve
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
CN110831547B (zh) 2017-06-21 2022-07-15 爱德华兹生命科学公司 双丝型件有限扩张心脏瓣膜
US10639152B2 (en) 2017-06-21 2020-05-05 Edwards Lifesciences Corporation Expandable sheath and methods of using the same
WO2019006152A1 (en) 2017-06-28 2019-01-03 Harmony Development Group, Inc. INFLATABLE TRANSDUCTION IMPLANT SYSTEM COMPRISING AN ANNULAR DOUBLE FORCE TRANSDUCTION IMPLANT
CN110891526A (zh) 2017-06-30 2020-03-17 爱德华兹生命科学公司 用于经导管植入式设备的锁定和释放机构
CA3068313A1 (en) 2017-06-30 2019-01-03 Edwards Lifesciences Corporation Docking stations for transcatheter valves
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
EP3651694A1 (en) * 2017-07-10 2020-05-20 Coramaze Technologies GmbH Heart implant
US10857334B2 (en) 2017-07-12 2020-12-08 Edwards Lifesciences Corporation Reduced operation force inflator
US10918473B2 (en) 2017-07-18 2021-02-16 Edwards Lifesciences Corporation Transcatheter heart valve storage container and crimping mechanism
KR102617878B1 (ko) 2017-08-11 2023-12-22 에드워즈 라이프사이언시스 코포레이션 인공 심장 판막용 밀봉 요소
US11083575B2 (en) 2017-08-14 2021-08-10 Edwards Lifesciences Corporation Heart valve frame design with non-uniform struts
US10932903B2 (en) 2017-08-15 2021-03-02 Edwards Lifesciences Corporation Skirt assembly for implantable prosthetic valve
US10898319B2 (en) 2017-08-17 2021-01-26 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US10973628B2 (en) 2017-08-18 2021-04-13 Edwards Lifesciences Corporation Pericardial sealing member for prosthetic heart valve
US10722353B2 (en) 2017-08-21 2020-07-28 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US10806573B2 (en) 2017-08-22 2020-10-20 Edwards Lifesciences Corporation Gear drive mechanism for heart valve delivery apparatus
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11141145B2 (en) 2017-08-25 2021-10-12 Edwards Lifesciences Corporation Devices and methods for securing a tissue anchor
US11051939B2 (en) 2017-08-31 2021-07-06 Edwards Lifesciences Corporation Active introducer sheath system
US10973629B2 (en) 2017-09-06 2021-04-13 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11051940B2 (en) 2017-09-07 2021-07-06 Edwards Lifesciences Corporation Prosthetic spacer device for heart valve
US11147667B2 (en) 2017-09-08 2021-10-19 Edwards Lifesciences Corporation Sealing member for prosthetic heart valve
US11065117B2 (en) * 2017-09-08 2021-07-20 Edwards Lifesciences Corporation Axisymmetric adjustable device for treating mitral regurgitation
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC SEALING DEVICE FOR USE AS A VASCULAR DUCT IMPLANT FOR REDUCING ENDOFUCTION
US11040174B2 (en) 2017-09-19 2021-06-22 Edwards Lifesciences Corporation Multi-direction steerable handles for steering catheters
CN115177404A (zh) 2017-10-18 2022-10-14 爱德华兹生命科学公司 导管组合件
US11207499B2 (en) 2017-10-20 2021-12-28 Edwards Lifesciences Corporation Steerable catheter
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
US10799350B2 (en) 2018-01-05 2020-10-13 Edwards Lifesciences Corporation Percutaneous implant retrieval connector and method
US10076415B1 (en) 2018-01-09 2018-09-18 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10507109B2 (en) 2018-01-09 2019-12-17 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10245144B1 (en) 2018-01-09 2019-04-02 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10231837B1 (en) 2018-01-09 2019-03-19 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10105222B1 (en) 2018-01-09 2018-10-23 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10159570B1 (en) 2018-01-09 2018-12-25 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10123873B1 (en) 2018-01-09 2018-11-13 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10111751B1 (en) 2018-01-09 2018-10-30 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10238493B1 (en) 2018-01-09 2019-03-26 Edwards Lifesciences Corporation Native valve repair devices and procedures
US10136993B1 (en) 2018-01-09 2018-11-27 Edwards Lifesciences Corporation Native valve repair devices and procedures
CN111655198A (zh) 2018-01-09 2020-09-11 爱德华兹生命科学公司 天然瓣膜修复设备和程序
US10973639B2 (en) 2018-01-09 2021-04-13 Edwards Lifesciences Corporation Native valve repair devices and procedures
WO2019144121A1 (en) 2018-01-22 2019-07-25 Edwards Lifesciences Corporation Heart shape preserving anchor
CN111565678B (zh) 2018-01-23 2023-07-07 爱德华兹生命科学公司 假体瓣膜保持器、系统和方法
WO2019145947A1 (en) 2018-01-24 2019-08-01 Valtech Cardio, Ltd. Contraction of an annuloplasty structure
EP3743014B1 (en) 2018-01-26 2023-07-19 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
WO2019152598A2 (en) 2018-02-02 2019-08-08 Cedars-Sinai Medical Center Delivery platforms, devices, and methods for tricuspid valve repair
EP3749255A4 (en) 2018-02-08 2022-02-23 Invalve Therapeutics, Inc. METHODS, DEVICE AND DEVICES FOR THE TREATMENT OF HEART VALVES
JP7300455B2 (ja) 2018-02-09 2023-06-29 ザ プロボースト，フェローズ，ファンデーション スカラーズ，アンド ジ アザー メンバーズ オブ ボード，オブ ザ カレッジ オブ ザ ホーリー アンド アンディバイデッド トリニティ オブ クイーン エリザベス ニア ダブリン 心臓弁療法デバイス
WO2019173385A1 (en) 2018-03-05 2019-09-12 Harmony Development Group, Inc. A force transducting implant system for the mitigation of atrioventricular pressure gradient loss and the restoration of healthy ventricular geometry
US11026791B2 (en) 2018-03-20 2021-06-08 Medtronic Vascular, Inc. Flexible canopy valve repair systems and methods of use
US11285003B2 (en) 2018-03-20 2022-03-29 Medtronic Vascular, Inc. Prolapse prevention device and methods of use thereof
EP3768176B1 (en) 2018-03-23 2024-03-20 NeoChord, Inc. Device for suture attachment for minimally invasive heart valve repair
US11389297B2 (en) 2018-04-12 2022-07-19 Edwards Lifesciences Corporation Mitral valve spacer device
US11207181B2 (en) 2018-04-18 2021-12-28 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
US11318011B2 (en) 2018-04-27 2022-05-03 Edwards Lifesciences Corporation Mechanically expandable heart valve with leaflet clamps
US11173030B2 (en) 2018-05-09 2021-11-16 Neochord, Inc. Suture length adjustment for minimally invasive heart valve repair
US11253360B2 (en) 2018-05-09 2022-02-22 Neochord, Inc. Low profile tissue anchor for minimally invasive heart valve repair
US11007061B2 (en) 2018-05-24 2021-05-18 Edwards Lifesciences Corporation Adjustable percutaneous heart valve repair system
US11844914B2 (en) 2018-06-05 2023-12-19 Edwards Lifesciences Corporation Removable volume indicator for syringe
USD908874S1 (en) 2018-07-11 2021-01-26 Edwards Lifesciences Corporation Collapsible heart valve sizer
AU2019301967A1 (en) 2018-07-12 2021-01-21 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty systems and locking tools therefor
US20200069426A1 (en) * 2018-08-28 2020-03-05 Edwards Lifesciences Corporation Methods and devices for ventricular reshaping and heart valve reshaping
US11857441B2 (en) 2018-09-04 2024-01-02 4C Medical Technologies, Inc. Stent loading device
CN113194854A (zh) 2018-09-07 2021-07-30 尼奥绰德有限公司 用于微创心脏瓣膜修复的缝线附接装置
EP3620133A1 (en) * 2018-09-07 2020-03-11 AVVie GmbH Implant for improving coaptation of an artrioventricular valve
CN110960279B (zh) * 2018-09-29 2023-06-16 上海佐心医疗科技有限公司 左心耳封堵器及左心耳封堵系统
CA3115270A1 (en) 2018-10-05 2020-04-09 Shifamed Holdings, Llc Prosthetic cardiac valve devices, systems, and methods
US10945844B2 (en) 2018-10-10 2021-03-16 Edwards Lifesciences Corporation Heart valve sealing devices and delivery devices therefor
KR20210082188A (ko) 2018-10-19 2021-07-02 에드워즈 라이프사이언시스 코포레이션 비-원통형 프레임을 갖는 인공 심장 판막
US11779728B2 (en) 2018-11-01 2023-10-10 Edwards Lifesciences Corporation Introducer sheath with expandable introducer
CA3118599A1 (en) 2018-11-08 2020-05-14 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
WO2020163504A1 (en) 2019-02-06 2020-08-13 inQB8 Medical Technologies, LLC Intra-cardiac left atrial and dual support systems
CR20210427A (es) 2019-02-14 2022-03-30 Edwards Lifesciences Corp Dispositivos de sellado de válvulas cardíacas y dispositivos de suministro para los mismos
EP3941391A4 (en) 2019-03-19 2022-11-23 Shifamed Holdings, LLC HEART VALVE PROSTHESIS, SYSTEMS AND PROCEDURES
CN113873973B (zh) 2019-03-26 2023-12-22 爱德华兹生命科学公司 假体心脏瓣膜
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
EP3955855A4 (en) 2019-04-16 2023-01-25 NeoChord, Inc. TRANSVERSE HELICAL HEART ANCHOR FOR MINIMALLY INVASIVE HEART VALVE REPAIR
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
EP3972534A4 (en) 2019-05-22 2023-08-02 Triflo Cardiovascular Inc. HEART VALVE RETENTION DEVICE
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
CN110279495B (zh) * 2019-06-25 2022-08-26 陈翔 一种自膨胀心脏瓣膜假体
CA3148739A1 (en) 2019-08-05 2021-02-11 Croivalve Ltd. Apparatus and methods for treating a defective cardiac valve
CR20210640A (es) 2019-10-29 2022-05-30 Valtech Cardio Ltd Tecnologías de anuloplastia y anclaje de tejido
WO2021126778A1 (en) 2019-12-16 2021-06-24 Edwards Lifesciences Corporation Valve holder assembly with suture looping protection
CN111195166A (zh) * 2020-01-14 2020-05-26 启晨(上海)医疗器械有限公司 一种可编织的心脏瓣膜装置及其制作方法、使用方法
US11931253B2 (en) 2020-01-31 2024-03-19 4C Medical Technologies, Inc. Prosthetic heart valve delivery system: ball-slide attachment
BR112023002487A2 (pt) 2020-08-24 2023-05-02 Edwards Lifesciences Corp Cobertura de balão para um aparelho de distribuição para uma válvula cardíaca protética expansível
JP2023540067A (ja) 2020-08-31 2023-09-21 エドワーズ ライフサイエンシーズ コーポレイション 圧着及びデバイス準備のためのシステム及び方法
IL301918A (en) * 2020-10-09 2023-06-01 Coramaze Tech Ltd A device for treating heart valve problems
US11464634B2 (en) 2020-12-16 2022-10-11 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation with secondary anchors
US11759321B2 (en) 2021-06-25 2023-09-19 Polares Medical Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
CN113679512A (zh) * 2021-08-11 2021-11-23 上海傲流医疗科技有限公司 一种治疗三尖瓣返流的修复装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3671979A (en) * 1969-09-23 1972-06-27 Univ Utah Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve
US3898701A (en) * 1974-01-17 1975-08-12 Russa Joseph Implantable heart valve
US5133732A (en) 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US5312341A (en) 1992-08-14 1994-05-17 Wayne State University Retaining apparatus and procedure for transseptal catheterization
ES2157918T3 (es) * 1993-12-14 2001-09-01 Sante Camilli Una valvula percutanea implantable para su uso en vasos sanguineos.
US5554184A (en) * 1994-07-27 1996-09-10 Machiraju; Venkat R. Heart valve
FR2728457B1 (fr) 1994-12-21 1997-03-21 Franceschi Claude Valve artificielle pour vaisseau sanguin
US6182664B1 (en) 1996-02-19 2001-02-06 Edwards Lifesciences Corporation Minimally invasive cardiac valve surgery procedure
US5738649A (en) 1996-04-16 1998-04-14 Cardeon Corporation Peripheral entry biventricular catheter system for providing access to the heart for cardiopulmonary surgery or for prolonged circulatory support of the heart
US6482224B1 (en) 1996-08-22 2002-11-19 The Trustees Of Columbia University In The City Of New York Endovascular flexible stapling device
NL1004827C2 (nl) * 1996-12-18 1998-06-19 Surgical Innovations Vof Inrichting voor het reguleren van de bloedsomloop.
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
WO1999000059A1 (en) * 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6200315B1 (en) 1997-12-18 2001-03-13 Medtronic, Inc. Left atrium ablation catheter
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6752813B2 (en) * 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
CA2620783C (en) 1999-04-09 2011-04-05 Evalve, Inc. Methods and apparatus for cardiac valve repair
US7226467B2 (en) * 1999-04-09 2007-06-05 Evalve, Inc. Fixation device delivery catheter, systems and methods of use
US6312464B1 (en) * 1999-04-28 2001-11-06 NAVIA JOSé L. Method of implanting a stentless cardiac valve prosthesis
US6758830B1 (en) 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US6312447B1 (en) * 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US7018406B2 (en) * 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20020128708A1 (en) * 1999-12-09 2002-09-12 Northrup William F. Annuloplasty system
US6402781B1 (en) * 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
WO2001056512A1 (en) * 2000-02-02 2001-08-09 Snyders Robert V Artificial heart valve
US20050070999A1 (en) * 2000-02-02 2005-03-31 Spence Paul A. Heart valve repair apparatus and methods
US6797002B2 (en) * 2000-02-02 2004-09-28 Paul A. Spence Heart valve repair apparatus and methods
US6929658B1 (en) 2000-03-09 2005-08-16 Design & Performance-Cyprus Limited Stent with cover connectors
US6454799B1 (en) * 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US7083628B2 (en) 2002-09-03 2006-08-01 Edwards Lifesciences Corporation Single catheter mitral valve repair device and method for use
US6419695B1 (en) * 2000-05-22 2002-07-16 Shlomo Gabbay Cardiac prosthesis for helping improve operation of a heart valve
US6869444B2 (en) 2000-05-22 2005-03-22 Shlomo Gabbay Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve
US6840246B2 (en) * 2000-06-20 2005-01-11 University Of Maryland, Baltimore Apparatuses and methods for performing minimally invasive diagnostic and surgical procedures inside of a beating heart
US6419696B1 (en) * 2000-07-06 2002-07-16 Paul A. Spence Annuloplasty devices and related heart valve repair methods
SE0002878D0 (sv) * 2000-08-11 2000-08-11 Kimblad Ola Device and method for treatment of atrioventricular regurgitation
US7381220B2 (en) * 2000-09-20 2008-06-03 Ample Medical, Inc. Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet
US8784482B2 (en) * 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
US6602288B1 (en) * 2000-10-05 2003-08-05 Edwards Lifesciences Corporation Minimally-invasive annuloplasty repair segment delivery template, system and method of use
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6482228B1 (en) * 2000-11-14 2002-11-19 Troy R. Norred Percutaneous aortic valve replacement
US6790231B2 (en) * 2001-02-05 2004-09-14 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
JP4184794B2 (ja) 2001-02-05 2008-11-19 ビアカー・インコーポレーテッド 僧帽弁の機能を改良するための方法及び装置
US20020107531A1 (en) 2001-02-06 2002-08-08 Schreck Stefan G. Method and system for tissue repair using dual catheters
US6619291B2 (en) * 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
US6936067B2 (en) 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent
FR2826863B1 (fr) * 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US20030078654A1 (en) * 2001-08-14 2003-04-24 Taylor Daniel C. Method and apparatus for improving mitral valve function
JP4458845B2 (ja) * 2001-10-01 2010-04-28 アンプル メディカル，インコーポレイテッド 医療用デバイス
US6893460B2 (en) 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US6575971B2 (en) 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
US6902575B2 (en) 2001-12-18 2005-06-07 Linvatec Biomaterials, Inc. Stent delivery apparatus and method
US20030120340A1 (en) 2001-12-26 2003-06-26 Jan Liska Mitral and tricuspid valve repair
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US7125420B2 (en) 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US7004958B2 (en) * 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
US6926743B1 (en) 2002-05-21 2005-08-09 Timothy A. M. Chuter Biological stent-graft
US8348963B2 (en) * 2002-07-03 2013-01-08 Hlt, Inc. Leaflet reinforcement for regurgitant valves
WO2004012583A2 (en) 2002-08-01 2004-02-12 The General Hospital Corporation Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation
US8172856B2 (en) * 2002-08-02 2012-05-08 Cedars-Sinai Medical Center Methods and apparatus for atrioventricular valve repair
DE60318861T2 (de) * 2002-08-13 2009-01-08 The General Hospital Corp., Boston Herzvorrichtungen für die perkutane reparatur von atrioventrikulären klappen
AU2003268220B8 (en) * 2002-08-28 2010-01-21 Hlt, Inc. Method and device for treating diseased valve
AU2003290979A1 (en) 2002-11-15 2004-06-15 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method and device for catheter-based repair of cardiac valves
US20040162514A1 (en) 2003-02-14 2004-08-19 Scout Medical Technologies System and method for controlling differential pressure in a cardio-vascular system
US20040193259A1 (en) * 2003-03-25 2004-09-30 Shlomo Gabbay Sizing apparatus for cardiac prostheses and method of using same
US7175656B2 (en) * 2003-04-18 2007-02-13 Alexander Khairkhahan Percutaneous transcatheter heart valve replacement
EP1615595B1 (en) * 2003-04-24 2009-10-21 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
EP1472996B1 (en) 2003-04-30 2009-09-30 Medtronic Vascular, Inc. Percutaneously delivered temporary valve
US8052751B2 (en) * 2003-07-02 2011-11-08 Flexcor, Inc. Annuloplasty rings for repairing cardiac valves
WO2005007036A1 (en) 2003-07-18 2005-01-27 Brivant Research & Development Limited A device for correcting inversion of the leaflets of a leaflet valve in the heart
US7160322B2 (en) * 2003-08-13 2007-01-09 Shlomo Gabbay Implantable cardiac prosthesis for mitigating prolapse of a heart valve
US20050038509A1 (en) * 2003-08-14 2005-02-17 Ashe Kassem Ali Valve prosthesis including a prosthetic leaflet
WO2005027797A1 (en) 2003-09-23 2005-03-31 Ersin Erek A mitral web apparatus for mitral valve insufficiencies
US20050075713A1 (en) * 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US20050228495A1 (en) * 2004-01-15 2005-10-13 Macoviak John A Suspended heart valve devices, systems, and methods for supplementing, repairing, or replacing a native heart valve
WO2005087140A1 (en) * 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US7704277B2 (en) 2004-09-14 2010-04-27 Edwards Lifesciences Ag Device and method for treatment of heart valve regurgitation
US20070219630A1 (en) 2004-11-24 2007-09-20 Xi Chu Devices and Methods for Beating Heart Cardiac Surgeries
WO2006064490A1 (en) 2004-12-15 2006-06-22 Mednua Limited A medical device suitable for use in treatment of a valve
SE531468C2 (sv) * 2005-04-21 2009-04-14 Edwards Lifesciences Ag En anordning för styrning av blodflöde
WO2006127509A2 (en) 2005-05-20 2006-11-30 Mayo Foundation For Medical Education And Research Devices and methods for reducing cardiac valve regurgitation
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US8092525B2 (en) 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
US8932348B2 (en) * 2006-05-18 2015-01-13 Edwards Lifesciences Corporation Device and method for improving heart valve function

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5397351A (en) * 1991-05-13 1995-03-14 Pavcnik; Dusan Prosthetic valve for percutaneous insertion
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9592118B2 (en) 2011-01-28 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valve regurgitation
US9592121B1 (en) 2015-11-06 2017-03-14 Middle Peak Medical, Inc. Device, system, and method for transcatheter treatment of valvular regurgitation
US11850151B2 (en) 2019-07-15 2023-12-26 Evalve, Inc. Proximal element actuator fixation and release mechanisms

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