CN101185789B - Implantation type nerve micro-stimulus and gathering remote-controlled chip - Google Patents
Implantation type nerve micro-stimulus and gathering remote-controlled chip Download PDFInfo
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- CN101185789B CN101185789B CN2007101565131A CN200710156513A CN101185789B CN 101185789 B CN101185789 B CN 101185789B CN 2007101565131 A CN2007101565131 A CN 2007101565131A CN 200710156513 A CN200710156513 A CN 200710156513A CN 101185789 B CN101185789 B CN 101185789B
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Abstract
The invention discloses an implantable nerve micro-stimulation and collection remote control chip. The invention includes a brain nerve electrical stimulation and collection module, a nerve micro-stimulation and collection electrode array, an uplink wireless radio frequency communication module and a downlink wireless radio frequency communication and an energy coupling power supply module; the whole remote control device is arranged in the animal brain; the downlink wireless radio frequency communication and energy coupling power supply module receives the command which is send in from the outside, the brain nerve electrical stimulation and collection module is controlled to generate the stimulation signal and is responsible for the energy supply of the whole implantable chip remote control device by utilizing the radio frequency energy coupling principle after the analysis; the uplink wireless radio frequency communication module carries out the wireless output of the nerve electrical signal which is sent in by the brain nerve electrical stimulation and collection module; by implanting the chip in the animal brain, the invention can lead to a more compact system for collecting and controlling the physiological signals of animals, reduce the influence of the outside devices on the animals and increase the concealment and quality safety of the future practical field.
Description
Technical field
The present invention relates to a kind of remote-controlled chip technology, relate to a kind of implantation type nerve micro-stimulus and gathering remote-controlled chip specifically.
Background technology
Brain-machine interaction technology (BCI), research be how to link up brain internal information and external environment by non-natural method.It provides the transmitted in both directions passage for brain and environment, and external information can be input to nervous system from biomimetic sensor, and nerve signal also can be used to control the external electrical machinery.The nervous system original function can be repaired, improves even be expanded to this technology, and a kind of brand-new information interaction pattern is provided.
In recent years, along with the progress of Medical Technology and material science, the research of implanted electrode in the brain-machine interaction technology has obtained breakthrough progress.1999, the Nicolelis of Duke university leader's research group was implanted imperceptible electrode at the brain of stump-tailed macaque, made them can utilize E.E.G control mechanical arm.The professor Andersen leader's of California Institute of Technology research group was then published an article on Science in 2004, introduced laboratory animal under their training, can come cursor in the moving screen with consciousness, even when how the laboratory animal plan moves, just understand and dope its idea.
After 2000, the application of implanted electrode in brain-machine interaction obtained breakthrough progress.The Nicolelis of Duke university leader's research group is implanted imperceptible electrode at the brain of stump-tailed macaque, makes them can utilize E.E.G control mechanical arm.This important breakthrough is expected to make the spinal cord injury patient to utilize E.E.G to use machinery or various tool some day, even allows the partial paralysis person can mobile once again limbs.The professor RichardAndersen leader's of California Institute of Technology research group was then published an article on Science in 2004, introduced laboratory animal under their training, can come cursor in the moving screen with consciousness, or even its idea just can be understood and dope to laboratory animal when how plan moves.
In this field, high universities and colleges such as University of Science and Technology, present domestic Shandong, Shanghai Communications University, Xi'an and Zhejiang University have all carried out " animal walking motor control " aspect important function for of research in recent years, and these researchs have all obtained achievement preferably.
On the whole, from publishing the document on the magazine, the domestic and international at present telecontrol engineering in this research field all is to carry out under the condition of percutaneous external device.At least at present the domestic successful report that does not also occur based on " biorobot " of implanted chip telecontrol engineering also rarely has what is heard for the report of the promotion applied research of this technology under special environment.From use angle, there is following shortcoming in the wireless remote-measuring system of percutaneous implanted: 1) device brings certain influence for the action of animal at animal knapsack on one's body; 2) in technical finesses such as infection, biocompatibility, bring a series of problem; 3) when carrying out secret mission, do not possess disguise.Promote from The Application of Technology, need widen original simple behavior training and control, the control that organism is outer and the instinct combination of animal physiological system make this technology bring into play real effect in the application of reality.
Summary of the invention
The object of the invention is to provide a kind of implantation type nerve micro-stimulus and gathering remote-controlled chip.
The technical solution used in the present invention is:
Comprise cranial nerve electricity irritation and acquisition module, nerve micro-stimulus and acquisition electrode array, up-link wireless radio-frequency communication module, descending radio frequency communication and energy coupling power module; The cranial nerve electricity irritation directly is connected in lead-in wire bonding mode with the acquisition electrode array with nerve micro-stimulus with acquisition module; Descending radio frequency communication and energy coupling power module are connected in the SPI mode with the data channel of cranial nerve electricity irritation and acquisition module, and energy channel directly connects with lead; Up-link wireless radio-frequency communication module is connected in the SPI mode with acquisition module with the cranial nerve electricity irritation.
Described descending radio frequency communication and energy coupling power module comprise with the uplink/downlink antenna of IC regime design, instruction demodulator circuit, clock demodulator circuit, energy coupling rectification circuit and miniature rechargeable lithium ion batteries.Described instruction demodulator circuit, clock demodulator circuit and energy coupling rectification circuit directly are connected with uplink/downlink antenna with parallel way; Energy coupling rectification circuit directly is connected with miniature rechargeable lithium ion batteries.Described descending radio frequency communication and energy coupling power module are connected in the SPI mode with acquisition module with described cranial nerve electricity irritation by the instruction demodulator circuit; Described descending radio frequency communication and energy coupling power module directly are connected with acquisition module with described cranial nerve electricity irritation by the clock demodulator circuit; Described descending radio frequency communication and energy coupling power module directly are connected with acquisition module with described cranial nerve electricity irritation by energy coupling rectification circuit; Described descending radio frequency communication and energy coupling power module directly are connected with acquisition module with described cranial nerve electricity irritation by miniature rechargeable lithium ion batteries; Described descending radio frequency communication and energy coupling power module directly are connected with described up-link wireless radio-frequency communication module by energy coupling rectification circuit; Described descending radio frequency communication and energy coupling power module directly are connected with described up-link wireless radio-frequency communication module by miniature rechargeable lithium ion batteries;
Described up-link wireless radio-frequency communication module comprises uplink antenna and the signal modulation circuit with IC regime design, and described uplink antenna is a different antennae with the described uplink/downlink antenna that designs with IC regime; Described signal modulation circuit directly is connected with parallel way with uplink antenna; Described up-link wireless radio-frequency communication module is connected in the SPI mode with acquisition module with described cranial nerve electricity irritation by signal modulation circuit.
Described nerve micro-stimulus and acquisition electrode array are made of silicon chip and electrod-array; Electrod-array is made of 8 linearly aligned silicon electrodes, is spaced apart 100 microns between the electrode, and single electrode root width is 80 microns, and length is 3 millimeters;
Described cranial nerve electricity irritation and acquisition module comprise control nuclear, voltage or current driving circuit, voltage or current-mode selection circuit, polarity control circuit and channel selection circuit; Described control nuclear, voltage or current driving circuit, voltage or current-mode select circuit, polarity control circuit and channel selection circuit all to be designed to integral module with IC regime; And described voltage or current-mode select circuit, polarity control circuit and channel selection circuit all to be connected in the data/address bus mode with control nuclear, and wherein, voltage or current driving circuit are connected with control nuclear by analog-digital converter; Described cranial nerve electricity irritation is connected in the SPI mode with described up-link wireless radio-frequency communication module by the control kernel interface with acquisition module; Described cranial nerve electricity irritation directly is connected with described descending radio frequency communication and energy coupling power module by control nuclear-electric power supply interface and control nuclear-electric power supply interface with acquisition module; Described cranial nerve electricity irritation is connected in the SPI mode with described descending radio frequency communication and energy coupling power module by the control kernel interface with acquisition module; Described cranial nerve electricity irritation directly is connected with electrod-array by described channel selection circuit with acquisition module; Described cranial nerve electricity irritation directly is connected with electrod-array by described analog to digital conversion circuit with acquisition module.
Described cranial nerve electricity irritation and acquisition module, the up-link wireless radio-frequency communication module except that uplink antenna, descending radio frequency communication and energy coupling power module make and are encapsulated in the same surface of described silicon chip with the integrated circuit form; Described uplink antenna is encapsulated in the described silicon chip and described cranial nerve electricity irritation and acquisition module, the up-link wireless radio-frequency communication module except that uplink antenna, another relative surface of descending radio frequency communication and surface, energy coupling power module place.
The invention has the beneficial effects as follows:
By in animal brain, implanting this chip, utilize the bio-sensing function of animal self, obtain the sensation of animal, the behavior of control animal, make animal have purpose must finish activities such as seeking target, location in the unapproachable area of the mankind, be reduced in the human danger that is faced in hazardous environment or the battlefield greatly, all have been widely used in fields such as military surveillance, border drug law enforcement, the disaster relief.
Description of drawings
Fig. 1 is the installation schematic diagram of chip of the present invention.
Wherein, 1. descending radio frequency communication and energy coupling power module, 2. up-link wireless radio-frequency communication module, 3. cranial nerve electricity irritation and acquisition module, 4. silicon chip, 5. microelectrode pad, 6. microelectrode array, 7. binding lead-in wire, 8. uplink antenna.
Fig. 2 is the theory diagram of chip of the present invention.
Fig. 3 is descending radio frequency communication and energy coupling power module frame chart.
Fig. 4 is energy coupling rectification and mu balanced circuit schematic diagram.
Fig. 5 is descending radio frequency communication ASK demodulator circuit schematic diagram.
Fig. 6 is a up-link wireless radio-frequency communication module frame chart.
Fig. 7 is a up-link wireless radio-frequency communication module FSK modulation circuit schematic diagram.
Fig. 8 is the composition frame chart of cranial nerve electricity irritation and acquisition module.
Fig. 9 is voltage or current driving circuit schematic diagram.
Figure 10 is that voltage or current-mode are selected and the polarity control circuit schematic diagram.
Figure 11 is the channel selection circuit schematic diagram.
Figure 12 is a charge redistribution formula digital-to-analog converter circuits schematic diagram.
Figure 13 is a Δ ∑ analog-digital converter schematic diagram.
The specific embodiment
As shown in Figure 1, a kind of implantation type nerve micro-stimulus and gathering remote-controlled chip comprise descending radio frequency communication and energy coupling power module 1, up-link wireless radio-frequency communication module 2, cranial nerve electricity irritation and acquisition module 3, nerve micro-stimulus and acquisition electrode array 6; Nerve micro-stimulus and acquisition electrode array 6 are positioned at the integrated circuit sidepiece, are integrated into a chip with described cranial nerve electricity irritation and acquisition module 3, nerve micro-stimulus and acquisition electrode array 6, up-link wireless radio-frequency communication module 2, descending radio frequency communication and energy coupling power module 1.Described cranial nerve electricity irritation and acquisition module 3, nerve micro-stimulus and acquisition electrode array 6, up-link wireless radio-frequency communication module 2 other parts, descending radio frequency communication and the energy coupling power module 1 except that uplink antenna 8 makes and is encapsulated in the same surface of described silicon chip with the integrated circuit form.Described uplink antenna 8 is encapsulated in the described silicon chip and described cranial nerve electricity irritation and acquisition module 3, nerve micro-stimulus and acquisition electrode array 6, up-link wireless radio-frequency communication module 2 other parts, another relative surface of descending radio frequency communication and surface, energy coupling power module 1 place except that uplink antenna 8.Silicon chip 4 is of a size of 10mm * 10mm.
As shown in Figure 2, the cranial nerve electricity irritation directly is connected in lead-in wire bonding mode with acquisition electrode array 6 with nerve micro-stimulus with acquisition module 3; Descending radio frequency communication and energy coupling power module 1 are connected in the SPI mode with the data channel of cranial nerve electricity irritation and acquisition module 3, and the system clock passage directly is connected with lead with the energy channel that comprises direct energy supply and battery functi on; Up-link wireless radio-frequency communication module 2 is connected in the SPI mode with acquisition module 3 with the cranial nerve electricity irritation.
As shown in Figure 3, descending radio frequency communication and energy coupling power module 6 comprise uplink/downlink antenna, energy coupling rectification circuit, instruction demodulator circuit, clock demodulator circuit and miniature rechargeable lithium ion batteries; Uplink/downlink antenna receives the ASK rf modulated signal of 13.56MHz, utilizes energy coupling rectification circuit to extract energy, as the power supply of entire chip; The operation principle of energy coupling rectification circuit utilizes metal-oxide-semiconductor to realize that the function of diode is configured bridge rectifier and carries out rectification as shown in Figure 4, and the mu balanced circuit that constitutes of reference voltage source of being made by resistance and diode and comparison amplifier carries out voltage stabilizing then; The instruction demodulator circuit of descending radio frequency communication and energy coupling power module 6 is identical with the principle of clock demodulator circuit, as shown in Figure 5, am signals becomes monolateral envelope through behind the diode, during through low pass, the low frequency envelope of modulation signal is proposed, pass through high-pass filtering circuit filtering flip-flop then, become digital signal by the amplifier rectification then.
As shown in Figure 6, up-link wireless radio-frequency communication module 2, on the uplink antenna 8 and connect modulation circuit, its operation principle as shown in Figure 7, variodenser Δ C, finish the branch road break-make by metal-oxide-semiconductor, control signal is the digital signal of control nuclear serial input, realizes frequency modulation(PFM) and the electroneurographic signal of gathering is sent in keying frequency displacement (FSK) mode under the frequency of 433MHz.
As shown in Figure 8, cranial nerve electricity irritation and acquisition module 3 comprise control nuclear, voltage or current driving circuit, voltage or current-mode selection and polarity control circuit, channel selection circuit, D/A converting circuit and analog to digital conversion circuit; Control nuclear is write control and logic function by the Verilog hardware description language, again by being processed by the CMOS standard technology behind the eda software formation logic array routing figure; Voltage or current driving circuit principle are gone into shown in Figure 9, the negative feedback amplification driving circuit that is made of amplifier U1; Voltage or current-mode are selected and the polarity control circuit principle is gone into shown in Figure 10, switching pin INA and INB by control nuclear control cmos analog switch U2, finish the gating of curtage signalling channel by control INA, thereby realize the gating of voltage or current signal, by control INB, the flow direction of finishing electric current is switched, thereby realizes the stimulation of positive-negative polarity; The channel selection circuit principle is gone into shown in Figure 11, opens the U3 pass by the CMOS simulation and constitutes, and control nuclear control Switch Control pin INA and INB by the various combination of INA and INB, finish twin-channel gating; D/A converting circuit as shown in figure 12, be 5 charge redistribution formula digital to analog converters, during the conversion beginning, all switch ground connection, out is output as zero, computing amplifier anode input current potential is the dividing potential drop between Vf end and the ground when work, and the relation of dividing potential drop then is the ratio of weighting equivalent capacity between the node, thereby realizes the conversion to digital signal; The analog to digital conversion circuit block diagram is 8 Δ ∑ analog-digital converters as shown in figure 13, and Δ ∑ analog-digital converter is an industry common-mode digital to analog converter, and principle repeats no more; Control nuclear is received dateout, channel selecting data, the Polarity Control order that parses electric current and voltage select command, DA after the control signal; Electric current and voltage select command input voltage or current-mode are selected circuit, and the dateout of DA is transported to D/A converting circuit, and channel selecting data input channel is selected circuit, Polarity Control order input polarity control circuit.D/A converting circuit is handled 5 input data, produces the analogue signal that can stimulate behind overvoltage or current driving circuit, is conveyed into channel selection circuit.Channel selection circuit receives analogue signal, becomes stimulus signal after the polarity control circuit conversion, then by outputing to after the channel selecting on the passage of being determined by the channel selecting data; Nerve signal converts parallel input data to through analog to digital conversion circuit and is input to control nuclear, is changed to serial data by the control consideration convey.
During application, entire chip is implanted in the animal brain, described nerve micro-stimulus inserts cerebral tissue with acquisition electrode array 6 and directly contacts with functioning cell.Stimulating course: extraneous power transfer signal is received and rectification by described descending radio frequency communication and energy coupling power module 1 by uplink/downlink antenna, for system provides power supply.Extraneous control signal is also arrived control nuclear after the demodulation by uplink/downlink antenna by described descending radio frequency communication and 1 reception of energy coupling power module.Control nuclear transfers control signal to corresponding control instruction, makes that on the one hand described cranial nerve electricity irritation and 3 of moulds of collection are finished channel selecting, stimulus type is selected and the direction selection operation; On the other hand stimulus signal is put mutually deserved electrode pair in described nerve micro-stimulus and the acquisition electrode array 6 by digital to analog converter output, thereby the part between electrode pair in the animal brain is stimulated.Gatherer process: extraneous control signal is set at drainage pattern with chip earlier, transmission direction be up after, EEG signals is gathered after analog-digital converter inputs to by described nerve micro-stimulus and acquisition electrode array 6 and is controlled nuclear, and control nuclear is delivered to described up-link wireless radio-frequency communication module 2 with signal and carried out being sent to outside receiving device with wireless mode after the FSK modulation.
Claims (5)
1. implantation type nerve micro-stimulus and gathering remote-controlled chip is characterized in that: comprise cranial nerve electricity irritation and acquisition module (3), nerve micro-stimulus and acquisition electrode array (6), up-link wireless radio-frequency communication module (2), descending radio frequency communication and energy coupling power module (1); The cranial nerve electricity irritation directly is connected in lead-in wire bonding mode with acquisition electrode array (6) with nerve micro-stimulus with acquisition module (3); Descending radio frequency communication and energy coupling power module (1) are connected in the serial peripheral interface mode with the data channel of cranial nerve electricity irritation with acquisition module (3), and energy channel directly connects with lead; Up-link wireless radio-frequency communication module (2) is connected in the serial peripheral interface mode with acquisition module (3) with the cranial nerve electricity irritation;
Described descending radio frequency communication and energy coupling power module (1) comprise with the uplink/downlink antenna of IC regime design, instruction demodulator circuit, clock demodulator circuit, energy coupling rectification circuit and miniature rechargeable lithium ion batteries; Described instruction demodulator circuit, clock demodulator circuit and energy coupling rectification circuit directly are connected with uplink/downlink antenna with parallel way; Energy coupling rectification circuit directly is connected with miniature rechargeable lithium ion batteries; Described descending radio frequency communication and energy coupling power module (1) are connected in the serial peripheral interface mode with acquisition module (3) with described cranial nerve electricity irritation by the instruction demodulator circuit; Described descending radio frequency communication and energy coupling power module (1) directly are connected with acquisition module (3) with described cranial nerve electricity irritation by the clock demodulator circuit; Described descending radio frequency communication and energy coupling power module (1) directly are connected with acquisition module (3) with described cranial nerve electricity irritation by energy coupling rectification circuit; Described descending radio frequency communication and energy coupling power module (1) directly are connected with acquisition module (3) with described cranial nerve electricity irritation by miniature rechargeable lithium ion batteries; Described descending radio frequency communication and energy coupling power module (1) directly are connected with described up-link wireless radio-frequency communication module (2) by energy coupling rectification circuit; Described descending radio frequency communication and energy coupling power module (1) directly are connected with described up-link wireless radio-frequency communication module (2) by miniature rechargeable lithium ion batteries;
2. a kind of implantation type nerve micro-stimulus according to claim 1 and gathering remote-controlled chip, it is characterized in that: described up-link wireless radio-frequency communication module (2) comprises uplink antenna (8) and the signal modulation circuit with the IC regime design, and described uplink antenna (8) is a different antennae with the uplink/downlink antenna with the IC regime design described in the claim 2; Described signal modulation circuit directly is connected with parallel way with uplink antenna (8); Described up-link wireless radio-frequency communication module (2) is connected in the serial peripheral interface mode with acquisition module (3) with described cranial nerve electricity irritation by signal modulation circuit.
3. a kind of implantation type nerve micro-stimulus according to claim 1 and gathering remote-controlled chip is characterized in that: described nerve micro-stimulus and acquisition electrode array are made of silicon chip (4) and electrod-array (6); Electrod-array (6) is made of 8 linearly aligned silicon electrodes, is spaced apart 100 microns between the electrode, and single electrode root width is 80 microns, and length is 3 millimeters;
4. a kind of implantation type nerve micro-stimulus according to claim 1 and gathering remote-controlled chip is characterized in that: described cranial nerve electricity irritation and acquisition module (3) comprise control nuclear, voltage or current driving circuit, voltage or current-mode selection circuit, polarity control circuit and channel selection circuit; Described control nuclear, voltage or current driving circuit, voltage or current-mode select circuit, polarity control circuit and channel selection circuit all to be designed to integral module with IC regime; And described voltage or current-mode select circuit, polarity control circuit and channel selection circuit all to be connected in the data/address bus mode with control nuclear, and wherein, voltage or current driving circuit are connected with control nuclear by analog-digital converter; Described cranial nerve electricity irritation is connected in the serial peripheral interface mode with described up-link wireless radio-frequency communication module (2) by control kernel interface (14) with acquisition module (3); Described cranial nerve electricity irritation directly is connected with described descending radio frequency communication and energy coupling power module (1) by control nuclear-electric power supply interface (15) and control nuclear-electric power supply interface (16) with acquisition module (3); Described cranial nerve electricity irritation is connected in the serial peripheral interface mode with described descending radio frequency communication and energy coupling power module (1) by control kernel interface (17) with acquisition module (3); Described cranial nerve electricity irritation directly is connected with electrod-array (6) by described channel selection circuit with acquisition module (3); Described cranial nerve electricity irritation directly is connected with electrod-array (6) by described analog to digital conversion circuit with acquisition module (3).
5. according to a kind of implantation type nerve micro-stimulus and the gathering remote-controlled chip of claim 1, it is characterized in that: described cranial nerve electricity irritation and acquisition module (3), the up-link wireless radio-frequency communication module (2) except that uplink antenna, descending radio frequency communication and energy coupling power module (1) make and are encapsulated in the same surface of described silicon chip (4) with the integrated circuit form; Described uplink antenna (8) is encapsulated in the described silicon chip (4) and described cranial nerve electricity irritation and acquisition module (3), the up-link wireless radio-frequency communication module (2) except that uplink antenna, another relative surface of descending radio frequency communication and surface, energy coupling power module (1) place.
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| CN2007101565131A CN101185789B (en) | 2007-11-06 | 2007-11-06 | Implantation type nerve micro-stimulus and gathering remote-controlled chip |
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| US9199089B2 (en) | 2011-01-28 | 2015-12-01 | Micron Devices Llc | Remote control of power or polarity selection for a neural stimulator |
| US9220897B2 (en) | 2011-04-04 | 2015-12-29 | Micron Devices Llc | Implantable lead |
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| US9409029B2 (en) | 2014-05-12 | 2016-08-09 | Micron Devices Llc | Remote RF power system with low profile transmitting antenna |
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