CN101242907A - 用于混合液体和涂覆支架的超声设备和方法 - Google Patents

用于混合液体和涂覆支架的超声设备和方法 Download PDF

Info

Publication number
CN101242907A
CN101242907A CNA2006800296818A CN200680029681A CN101242907A CN 101242907 A CN101242907 A CN 101242907A CN A2006800296818 A CNA2006800296818 A CN A2006800296818A CN 200680029681 A CN200680029681 A CN 200680029681A CN 101242907 A CN101242907 A CN 101242907A
Authority
CN
China
Prior art keywords
tip
mixing chamber
liquid
equipment
different liquids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800296818A
Other languages
English (en)
Inventor
艾拉兹·P·巴巴耶夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN101242907A publication Critical patent/CN101242907A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B5/00—Electrostatic spraying apparatus; Spraying apparatus with means for charging the spray electrically; Apparatus for spraying liquids or other fluent materials by other electric means
    • B05B5/025—Discharge apparatus, e.g. electrostatic spray guns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0623—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn
    • B05B17/063—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers coupled with a vibrating horn having an internal channel for supplying the liquid or other fluent material

Abstract

公开了用于混合两种或更多种液体的超声方法和设备。该超声方法和设备可混合包括药物、聚合物以及涂料的各种组分，以应用到多种医疗设备表面。该设备和技术可产生被不中断地/连续地输送到医疗设备表面的适当的混合物。该设备可包括专用的超声换能器/尖端结构，该超声换能器/尖端结构可允许在设置于振动尖端内部的混合室内混合不同液体。本发明的设备和方法可混合不同的药物，使用类似超声空化和辐射力的不同效应将它们应用到支架表面。此外，所公开的方法和设备可产生混合物，并可输送针对目标的、缓和的且分配可控性高的连续液体喷射，这种连续液体喷射能够减少昂贵药物的损耗。

Description

用于混合液体和涂覆支架的超声设备和方法
发明背景
发明领域
本发明涉及用于医疗器械的涂覆，且更具体地说，涉及采用超声能量来混合两种或更多种不同液体并涂覆任意的医疗器械表面的设备和方法。
相关技术背景
支架是一种通常小型的、圆柱形状的网状管，其被永久地插入到动脉中。支架有助于使动脉保持打开，以致血液能够穿过其流动。支架一般分为两类：a)金属裸支架；和b)药物洗脱支架。药物洗脱支架包含有潜在地减少动脉会再次变得阻塞的可能性的药物。
设计上支架通常是管状的，由细网和/或线构成，这些细网和/或线具有小直径并在各个部分之间界定了大量的狭窄空间。通常，支架因各种原因并利用各种工艺涂覆有一定范围的材料。由于支架的特定结构、设计和材料，因此可重复性地在无网纹(webbing)、拉丝(stringing)并在可控剂量的药物-聚合物涂料的情况下来均匀地涂覆支架的内表面和外表面一直是成问题的。
公开过支架的专利的例子包括Palmaz的美国专利No.4,739,762；Wiktor的美国专利No.5,133,732；Boneau的美国专利No.5,292,331；Barry等人的美国专利No.6,908,622；Hossayniy等人的美国专利No.6,908,624；和Reiss的美国专利No.6,913,617。
有多个涉及支架涂覆的美国公布专利申请，包括，例如：Sundar的美国专利公布No.2003/0225451 A1；Udipi等人的美国专利公布No.2004/0215336 A1；Pacetti等人的美国专利公布No.2004/0224001 A1；Stenzel的美国专利公布No.2004/0234748 A1；Sundar的美国专利公布No.2004/0236399 A1；和Byun的美国专利公布No.2004/0254638 A1。
根据上面所提到的专利和申请，通过不同的方法，如机械涂覆、气体喷涂、浸渍、极化涂覆、电荷(静电)涂覆或超声涂覆等，将涂料应用于支架的内表面和外表面。其中有一些如美国专利No.6,656,506利用了浸渍和喷射的组合。其中有几个利用了超声能量，例如美国专利No.6,767,673；而美国专利No.2005/0064088利用了超声喷射。在另一方法中，美国专利No.5,891,507公开了通过浸渍入超声浴来涂覆支架表面。
尽管存在这些涂覆技术和方法，但是这些相关技术存在许多缺陷和问题。例如，涂覆厚度的不均匀性、网纹、拉丝、支架表面上的裸点(bare spot)、药物浪费、过度喷射、难于控制药物流量、粘合性问题、长的干燥时间以及需要灭菌/卫生措施等等。
超声喷射器(Sonic and Materials Inc.，Misonix Inc.，Sono-Tek Inc.；美国专利No.4,153,201、4,655,393和5,516,043)通常通过使液体穿过超声仪器的尖端的中心孔来工作。已知的来自美国工程的申请使用气流来将气溶胶颗粒(aerosol particle)输送到涂覆表面。根据Sono-Tek网站，AccuMist和MicroMist系统是通过经由空气喷射或气流输送气溶胶颗粒来用于超声支架涂覆的。
已有气体超声喷射器之一是Celleration创面治疗申请(美国专利#5076266；64788754；6569099；6601581；6663554)，其产生喷射。在1986年颁予Babaev的苏联专利#1237261能够混合超声换能器尖端(ultrasonictransducer tip)外部的不同液体。
通常，支架需要涂覆有单层药物和/或聚合物。现今的技术要求在涂覆之前混合药物或聚合物。这可能导致耗时问题，例如聚合物在混合后会聚合。
因此，需要一种用于将两种或更多种不同药物与聚合物混合在一起的方法和装置以及支架的无缺陷、可控的涂覆过程。
发明内容
根据本发明，描述了用于支架涂覆的超声方法和设备。本超声方法和设备可在由超声换能器尖端界定的混合室(腔)内提供两种或更多种不同液体的适当的混合。根据本发明的设备可产生用于表面涂覆的均匀、缓和以及针对目标的喷射(targeted spray)。
一方面，本发明涉及不中断地混合不同液体，并用可控厚度层涂覆支架而无网纹和拉丝。
另一方面，本发明可提供包含设置在超声换能器尖端内部的混合室(腔)的设备。来自不同贮存器的受控量的不同液体可供应给超声尖端的混合室(腔)。超声尖端可以是圆柱形的、矩形的或以其他方式成形以产生适当的混合物。所产生的混合物可经中心孔输送到尖端的远端以产生细的喷射。
可采用精确注射泵通过毛细管作用和/或重力作用将液体可控地输送入混合室。当使用注射泵时，所输送的液体量可与涂层的体积或重量近似相同。
用于涂覆医疗器械的、包括支架的本发明的方法能够在超声尖端内由不同液体、药物、聚合物还有其他材料产生所期望的混合物，并且能不中断地向表面提供喷射。
根据本发明的方法还可在超声尖端的混合室内使用多种低频超声波的声效应，例如空化、微流动和驻波，而这些声效应通常未应用于液体混合或涂覆技术中。
该方法可包括在涂覆过程中使支架旋转并移动超声混合和涂覆头，以产生特殊的超声-声效应，这将在下面详细描述。为了达到高品质的效果，所有涂覆操作均通过专用软件程序来控制。
该方法和设备可混合不同液体例如药物、聚合物等，并可涂覆由不同材料制成的刚性、柔性、自膨式支架。
该方法还可包括将另外的气流引入混合和涂覆区域。气流可以是热的或是冷的，并可被引导通过混合室和/或在颗粒内喷射或独自喷射。
本发明的装置部分包括允许混合不同液体并不中断地产生喷射的超声尖端的特定结构。
超声频率范围可在20KHz到20MHz之间或更高。优选的频率是20KHz到200KHz，推荐的频率是30KHz。超声波振幅范围可在2微米到300微米之间或更大。因此，提供了一种用于通过不同液体的适当混合来不中断地超声涂覆支架而无网纹和拉丝的方法和装置。
本发明的一个方面提供了一种用于混合两种或更多种不同液体的方法和装置。
本发明的另一方面提供了一种用于混合两种或更多种不相容液体的方法和装置。
本发明的另一方面提供了一种用于混合两种或更多种不同药物、聚合物或药物与聚合物以用于涂覆医疗植入物例如支架的改进的方法和装置。
本发明的另一方面提供了一种用于混合两种或更多种不同液体如药物、聚合物或药物与聚合物并采用超声来涂覆支架的方法和装置。
本发明的另一方面提供了用于混合两种或更多种不同药物与聚合物的方法和装置，其提供涂覆层的可控厚度。
本发明的另一方面提供了用于同时混合不同液体、由适当的支架混合物涂料形成连续、均匀和定向喷射的方法和装置。
本发明的另一方面提供了用于同时混合不同液体、由适当的支架混合物涂料形成连续、均匀和定向喷射的方法和装置，其能避免如网纹、拉丝等的涂覆缺陷。
本发明的另一方面提供了用于同时混合不同液体、由适当的支架混合物涂料形成连续、均匀和定向喷射的方法和装置，其不用化学制品增强了支架的粘着性能。
本发明的另一方面提供了用于同时混合不同液体、由适当的支架混合物涂料形成连续、均匀和定向喷射的方法和装置，其在涂覆过程的同时沿结构的纵轴提供涂层的干燥。
本发明的另一方面提供了用于同时混合不同液体、由适当的支架混合物涂料形成连续、均匀和定向喷射的方法和装置，其在涂覆过程的同时沿结构的纵轴提供涂层的灭菌。
本发明的另一方面提供了用于形成适当的混合两种或更多种不同液体、产生喷射和涂覆表面的不中断过程的方法和装置。
从以下的书面描述和附图，本发明的这些和其他方面将变得更加明显。
附图说明
将参考优选实施方案的附图来显示和描述本发明，且可清楚地理解本发明的细节。
图1是根据本发明用于喷射的超声混合设备的实施方案的截面图。
图2展示了根据本发明将液体直接输送到超声尖端内部混合腔的设备的实施方案截面的前视图。液体输送管设置在垂直于尖端轴的一个径平面(platan)上。
图3展示了根据本发明将液体直接输送到超声尖端内部混合腔的设备的实施方案的截面。液体输送管沿超声尖端的纵轴设置在径平面上。
图4是根据本发明在超声尖端内部具有螺纹混合腔的设备的实施方案的截面图示。
图5展示了根据本发明的设备的实施方案的截面的前视图，其中一种液体通过超声换能器的中心孔输送到混合腔，而另一种液体通过垂直于超声尖端轴的管来输送。
图6A和6B以放大截面展示了具有圆形辐射壁(rounded radiation wall)的混合室的实施方案。
图7展示了超声尖端的实施方案，其为a)扩展平面、b)圆锥形、c)指数(exponential)、d)外部圆形、e)内部圆形聚焦和f)矩形远端构型。
发明详述
本发明提供了一种包含超声尖端1的设备，该超声尖端1界定混合室(腔)4。贯穿附图展示了有关方法和设备的本发明的优选实施方案。本领域的技术人员在审阅了本公开内容后将会立即理解由本发明提供的混合两种或更多种不同液体如药物和/或聚合物并不中断地涂覆支架的优势。
超声尖端1使用由超声换能器2提供的超声能量来混合材料并涂覆医疗设备。该方法在应用到涂覆支架和其他具有错综复杂的细部和复杂形状的装置时特别有用。根据本发明的超声尖端1能够提供两种或更多种药物和聚合物的高度精确可控的混合，且精细的、针对目标的喷射允许涂覆支架而无实质上的网纹、拉丝以及因混合而造成的昂贵药物的浪费。
本发明提供了一种新颖的超声尖端1和用于混合两种或更多种不同流体以涂覆支架的方法。在图1到7中展示了根据本发明的超声尖端1的实施方案。根据本发明，超声尖端1包括在超声尖端1内部的混合室/腔4。混合室4提供超声活动空间以用于在声力(acoustic force)作用下混合不同液体，该声力包括可在室4内部发生的空化现象。通常，室4是围绕超声尖端1纵轴的圆柱形形状。空化现象可发生在垂直于纵轴的室壁18和19之间。可提供一个或更多个注射泵(未显示)，用于通过设置在与纵轴垂直的径平面上的管5、6、7、8(图2)将不同液体输送入室4。液体输送管6、7、8可沿纵轴设置是本发明的一个实施方案(图3)。一方面，输送管6、7、8中的一个或更多个可提供加压流体。药物和/或聚合物的混合物可通过孔9以不中断的方式输送到尖端1的辐射表面11，用于产生喷射10并输送到涂覆表面/支架12。孔9的直径优选地必须小于混合室的直径。为了简化制造，超声换能器尖端1可包括远端部分3，该远端部分3经平面16上的螺纹连接以形成室4。远端部分3可配备有不同直径的中心孔9以按所需的颗粒大小来产生喷射10。为了避免远端部分3的松动，远端部分3必须优选地在振幅节点(amplitude node point)14上连接到尖端1。液体输送管(5、6、7、8)也必须优选地在振幅节点20上连接到尖端1。为了获得高质量的混合物，混合腔中心可匹配或接近振幅反节点(amplitude anti node point)15。
必须注意的是，不同温度的气流可通过管(5、6、7、8)中的一个输送入混合室/腔4，以改进液体混合和喷射涂覆过程。这可改变喷射体积、质量并可加快干燥过程。
不同液体的超声混合以及不中断地喷射过程、方法和设备的说明和描述：当不同液体(a、b、c)被供应到激活的混合室4时，壁19在超声辐射力作用下向前输送液滴/流。从壁18后退或弹回的加压液体流与新输送的不同液体流遭遇，并在超声辐射/压力和空化作用下产生适当的混合物。
混合室充满液体混合物之后，超声压力推动混合物通过中心孔9以形成喷射10，并将其输送到辐射表面11。当液体被输送且尖端振动时，混合和喷射涂覆过程不中断地进行。
在本发明的一个方面中，为了更有效且适当的混合过程，混合室4包含至少一个螺纹22、槽式环(groove ring)或波动形状(图5)。在这种情况下，螺纹的根部作为混合叶片(mixing blade)或勺，与超声能量一起推动待混合的不同液体。远端孔9也可被车螺纹(23)以用于更好的混合过程。
在另一方面中(图6)，为了更有效且适当的混合过程，混合室壁18和19可使内部成圆形(图6.a)，以产生很强的聚焦超声效应。室壁也可使外部成圆形(图6.b)，用于产生强力的空化效应来获得更适当的混合过程。在这种情况下，从混合室的放射状圆柱形壁反射的超声波使不同液体颗粒彼此相对地推。这些在超声空化和辐射压力作用下提供不同液体的适当的混合。
图7是超声尖端的a)扩展平面、b)圆锥形状、c)指数、d)外部圆形、e)内部圆形聚焦和f)矩形远端构型的图示。这些构型允许根据涂覆要求来控制喷射角度和质量。

Claims (15)

1.一种用于混合至少两种不同液体并涂覆至少一个支架的至少一部分的设备，其包括：
a)超声换能器，其具有尖端；
b)超声换能器尖端，其具有在振动尖端内部的混合室；
c)超声换能器尖端混合室，其具有管以将液体输送入室；以及
d)超声换能器尖端混合室，其具有中心孔以给待喷射的所述尖端的远端提供液体混合物。
2.如权利要求1所述的设备，其中超声尖端混合室具有螺纹或槽。
3.如权利要求1所述的设备，其中超声尖端混合室具有前端部分，所述前端部分在节点处经螺纹连接到尖端。
4.如权利要求1所述的设备，其中超声尖端混合室具有液体输送管，所述液体输送管在节点处连接到尖端。
5.如权利要求1所述的设备，其中超声尖端前端部分具有不同的几何形式/形状。
6.如权利要求1所述的设备，其中超声尖端混合室具有螺纹或槽。
7.如权利要求1所述的设备，其中液体混合室的后壁和/或前壁中的至少一个是平坦的。
8.如权利要求1所述的设备，其中液体混合室的后壁和/或前壁中的至少一个是圆形的或椭圆形的。
9.如权利要求1所述的设备，其中液体混合室的直径大于前端部分的中心孔直径。
10.一种用于混合至少两种不同液体的方法，其包括：
a)具有带有混合室的超声换能器尖端，所述混合室设置在振动尖端内部；
b)将至少两种不同液体输送入混合腔；
c)经由液体输送管中的一个输送至少两种不同液体和至少一种气流；
c)使用超声空化和辐射力由两种不同液体产生混合物；
d)经由中心孔将所述混合物输送到尖端的远端以产生喷射；
e)将混合物涂覆喷射引导并应用到支架上。
11.如权利要求10所述的方法，其包括：使用不同的超声波频率来混合在振动尖端内部的不同液体。
12.如权利要求10所述的方法，其进一步包括：使用不同的超声波振幅来混合在振动尖端内部的不同液体。
13.如权利要求10所述的方法，其中所述液体中的至少一种是治疗剂/药物。
14.如权利要求10所述的方法，其中所述液体中的至少一种是聚合物。
15.如权利要求10所述的方法，其中所述液体中的一种是混合物。
CNA2006800296818A 2005-08-16 2006-07-18 用于混合液体和涂覆支架的超声设备和方法 Pending CN101242907A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/204,872 US7896539B2 (en) 2005-08-16 2005-08-16 Ultrasound apparatus and methods for mixing liquids and coating stents
US11/204,872 2005-08-16

Publications (1)

Publication Number Publication Date
CN101242907A true CN101242907A (zh) 2008-08-13

Family

ID=37758024

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800296818A Pending CN101242907A (zh) 2005-08-16 2006-07-18 用于混合液体和涂覆支架的超声设备和方法

Country Status (9)

Country Link
US (2) US7896539B2 (zh)
EP (1) EP1915218B1 (zh)
JP (1) JP2009504396A (zh)
KR (1) KR20080040728A (zh)
CN (1) CN101242907A (zh)
AT (1) ATE460230T1 (zh)
CA (1) CA2659974A1 (zh)
DE (1) DE602006012847D1 (zh)
WO (1) WO2007021427A2 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108348699A (zh) * 2015-10-30 2018-07-31 强生消费者公司 无菌气溶胶雾化装置
CN108348697A (zh) * 2015-10-30 2018-07-31 强生消费者公司 无菌气溶胶雾化装置
CN114606499A (zh) * 2022-04-07 2022-06-10 燕山大学 一种表面具有微孔结构的金属及其制备方法与应用

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040030254A1 (en) * 2002-08-07 2004-02-12 Eilaz Babaev Device and method for ultrasound wound debridement
US7947010B2 (en) * 2005-07-08 2011-05-24 Depuy Products, Inc. Composition and system for wound decontamination
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US7943352B2 (en) 2006-03-29 2011-05-17 Bacoustics, Llc Apparatus and methods for vaccine development using ultrasound technology
US7846341B2 (en) * 2006-12-04 2010-12-07 Bacoustics, Llc Method of ultrasonically treating a continuous flow of fluid
US20080243047A1 (en) * 2007-03-27 2008-10-02 Babaev Eilaz P Ultrasound wound care device
US20080265055A1 (en) * 2007-04-30 2008-10-30 Ke-Ming Quan Ultrasonic nozzle
US20080265052A1 (en) * 2007-04-30 2008-10-30 Ke-Ming Quan Method of using an ultrasonic spray apparatus to coat a substrate
US7901388B2 (en) 2007-07-13 2011-03-08 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US20110160624A1 (en) * 2007-07-13 2011-06-30 Bacoustics, Llc Apparatus for creating a therapeutic solution and debridement with ultrasound energy
US20100324481A1 (en) * 2007-07-13 2010-12-23 Bacoustics, Llc Ultrasound pumping apparatus for use with the human body
US7896854B2 (en) * 2007-07-13 2011-03-01 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
US20090093870A1 (en) * 2007-10-05 2009-04-09 Bacoustics, Llc Method for Holding a Medical Device During Coating
US8689728B2 (en) * 2007-10-05 2014-04-08 Menendez Adolfo Apparatus for holding a medical device during coating
US8016208B2 (en) 2008-02-08 2011-09-13 Bacoustics, Llc Echoing ultrasound atomization and mixing system
US7950594B2 (en) * 2008-02-11 2011-05-31 Bacoustics, Llc Mechanical and ultrasound atomization and mixing system
US7830070B2 (en) * 2008-02-12 2010-11-09 Bacoustics, Llc Ultrasound atomization system
WO2013067041A1 (en) * 2011-11-01 2013-05-10 Indrani Deo Dispensing nozzle with an ultrasound activator
CA3003438C (en) 2015-10-30 2024-01-02 Johnson & Johnson Consumer Inc. Aseptic aerosol misting device
BR112018008475B1 (pt) 2015-10-30 2023-01-24 Johnson & Johnson Consumer Inc Método de gerar uma névoa de aerossol usando um dispositivo portátil, cápsula de dose unitária para uso com um gerador sônico e kit compreendendo a mesma
EP3551110A4 (en) 2016-12-12 2020-06-03 Neuronoff, Inc. ON THE CONTOURS OF A TARGET IN BODY TISSUE HARDENABLE AND MOLDABLE ELECTRODES AND METHODS FOR THE PRODUCTION AND PLACEMENT AND DISPENSER THEREFOR

Family Cites Families (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE634668A (zh) 1962-07-11
US3373752A (en) * 1962-11-13 1968-03-19 Inoue Kiyoshi Method for the ultrasonic cleaning of surfaces
US3334818A (en) * 1965-09-22 1967-08-08 Alfred M Moen Swivel spray aerators
US3400892A (en) * 1965-12-02 1968-09-10 Battelle Development Corp Resonant vibratory apparatus
US3561444A (en) 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3663288A (en) 1969-09-04 1972-05-16 American Cyanamid Co Physiologically acceptible elastomeric article
US3608832A (en) * 1969-09-04 1971-09-28 Energy Sciences Inc Spray nozzle assembly operable at low pressure
CS148449B1 (zh) 1970-03-13 1973-02-22
DE2445791C2 (de) 1974-09-25 1984-04-19 Siemens AG, 1000 Berlin und 8000 München Ultraschall-Flüssigkeitszerstäuber
GB1528163A (en) 1975-02-10 1978-10-11 Agfa Gevaert Process for the hardening of photographic layers
US4309989A (en) 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
US4301968A (en) * 1976-11-08 1981-11-24 Sono-Tek Corporation Transducer assembly, ultrasonic atomizer and fuel burner
US4391797A (en) 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4119094A (en) 1977-08-08 1978-10-10 Biosearch Medical Products Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
US4100309A (en) 1977-08-08 1978-07-11 Biosearch Medical Products, Inc. Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same
DE2811248C3 (de) 1978-03-15 1981-11-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Flüssigkeitszerstäuber
FR2443113B1 (fr) 1978-06-30 1985-12-06 Deutsch Pruef Messgeraete Procede et dispositif d'emission d'impulsions acoustiques, particulierement dans le domaine des ultra-sons, et application de ces impulsions notamment au controle non destructif de materiaux
JPS5848225B2 (ja) 1979-01-09 1983-10-27 オムロン株式会社 超音波液体霧化装置の霧化量制御方式
US4263188A (en) 1979-05-23 1981-04-21 Verbatim Corporation Aqueous coating composition and method
DE2930410A1 (de) 1979-07-26 1981-02-12 Bayer Ag Verfahren zur herstellung von stabilen waessrigen dispersionen von oligo- oder polyurethanen, sowie ihre verwendung als beschichtungsmittel fuer flexible oder nicht- flexible substrate
US4387024A (en) 1979-12-13 1983-06-07 Toray Industries, Inc. High performance semipermeable composite membrane and process for producing the same
US4675361A (en) 1980-02-29 1987-06-23 Thoratec Laboratories Corp. Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming
US4306816A (en) * 1980-04-04 1981-12-22 Folland Corporation Barodynamic resonator
NL189237C (nl) 1980-04-12 1993-02-16 Battelle Institut E V Inrichting voor het verstuiven van vloeistoffen.
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4373009A (en) 1981-05-18 1983-02-08 International Silicone Corporation Method of forming a hydrophilic coating on a substrate
SE430695B (sv) 1982-04-22 1983-12-05 Astra Meditec Ab Forfarande for framstellning av en hydrofil beleggning samt enligt forfarandet framstellda medicinska artiklar
US4487808A (en) 1982-04-22 1984-12-11 Astra Meditec Aktiebolag Medical article having a hydrophilic coating
SE430696B (sv) 1982-04-22 1983-12-05 Astra Meditec Ab Forfarande for framstellning av en hydrofil beleggning samt en enligt forfarandet framstelld medicinsk artikel
US4499154A (en) 1982-09-03 1985-02-12 Howard L. Podell Dipped rubber article
US4536179A (en) 1982-09-24 1985-08-20 University Of Minnesota Implantable catheters with non-adherent contacting polymer surfaces
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4541564A (en) * 1983-01-05 1985-09-17 Sono-Tek Corporation Ultrasonic liquid atomizer, particularly for high volume flow rates
US4492622A (en) 1983-09-02 1985-01-08 Honeywell Inc. Clark cell with hydrophylic polymer layer
SE452404B (sv) 1984-02-03 1987-11-30 Medinvent Sa Flerskiktat protesmaterial samt forfarande for dess framstellning
SU1237261A2 (ru) 1984-04-09 1986-06-15 Центр Методологии Изобретательства Устройство дл ультразвукового распылени жидкой среды
AU566085B2 (en) 1984-06-04 1987-10-08 Terumo Kabushiki Kaisha Medical instrument with surface treatment
US4684328A (en) 1984-06-28 1987-08-04 Piezo Electric Products, Inc. Acoustic pump
US4959074A (en) 1984-08-23 1990-09-25 Gergory Halpern Method of hydrophilic coating of plastics
US5037677A (en) 1984-08-23 1991-08-06 Gregory Halpern Method of interlaminar grafting of coatings
DE3574344D1 (en) 1984-08-29 1989-12-28 Omron Tateisi Electronics Co Ultrasonic atomizer
US4582654A (en) 1984-09-12 1986-04-15 Varian Associates, Inc. Nebulizer particularly adapted for analytical purposes
US4642267A (en) 1985-05-06 1987-02-10 Hydromer, Inc. Hydrophilic polymer blend
JPS61259784A (ja) 1985-05-13 1986-11-18 Toa Nenryo Kogyo Kk 超音波噴射用振動子
US5057371A (en) 1985-06-14 1991-10-15 Minnesota Mining And Manufacturing Company Aziridine-treated articles
US4923464A (en) 1985-09-03 1990-05-08 Becton, Dickinson And Company Percutaneously deliverable intravascular reconstruction prosthesis
US4659014A (en) * 1985-09-05 1987-04-21 Delavan Corporation Ultrasonic spray nozzle and method
US4705709A (en) 1985-09-25 1987-11-10 Sherwood Medical Company Lubricant composition, method of coating and a coated intubation device
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4748986A (en) 1985-11-26 1988-06-07 Advanced Cardiovascular Systems, Inc. Floppy guide wire with opaque tip
JPH065060B2 (ja) 1985-12-25 1994-01-19 株式会社日立製作所 内燃機関用超音波式燃料微粒化装置の駆動回路
EP0257091B1 (en) 1986-02-24 1993-07-28 Robert E. Fischell An intravascular stent and percutaneous insertion system
GB2189168B (en) 1986-04-21 1989-11-29 Aligena Ag Composite membranes useful in the separation of low molecular weight organic compounds from aqueous solutions containing inorganic salts
US4721117A (en) 1986-04-25 1988-01-26 Advanced Cardiovascular Systems, Inc. Torsionally stabilized guide wire with outer jacket
US4692352A (en) 1986-04-29 1987-09-08 The Kendall Company Method of making an adhesive tape
US4867173A (en) 1986-06-30 1989-09-19 Meadox Surgimed A/S Steerable guidewire
DE3627222A1 (de) 1986-08-11 1988-02-18 Siemens Ag Ultraschall-taschenzerstaeubergeraet
US5037656A (en) 1986-12-04 1991-08-06 Millipore Corporation Porous membrane having hydrophilic and cell growth promotions surface and process
US4834124A (en) * 1987-01-09 1989-05-30 Honda Electronics Co., Ltd. Ultrasonic cleaning device
US4734092A (en) 1987-02-18 1988-03-29 Ivac Corporation Ambulatory drug delivery device
US5211183A (en) 1987-05-13 1993-05-18 Wilson Bruce C Steerable memory alloy guide wires
US4850534A (en) 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
US5527337A (en) 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US4795458A (en) 1987-07-02 1989-01-03 Regan Barrie F Stent for use following balloon angioplasty
JPH088933B2 (ja) 1987-07-10 1996-01-31 日本ゼオン株式会社 カテ−テル
JPS6458263A (en) 1987-08-28 1989-03-06 Terumo Corp Intravascular introducing catheter
US4964409A (en) 1989-05-11 1990-10-23 Advanced Cardiovascular Systems, Inc. Flexible hollow guiding member with means for fluid communication therethrough
CS270372B1 (en) 1987-12-09 1990-06-13 Sulc Jiri Method of thin hydrophilic layers formation on surface of articles of non-hydrophilic methacrylic and acrylic polymers
US4841976A (en) 1987-12-17 1989-06-27 Schneider-Shiley (Usa) Inc. Steerable catheter guide
US4980231A (en) 1988-02-19 1990-12-25 Snyder Laboratories, Inc. Process for coating polymer surfaces and coated products produced using such process
US4943460A (en) 1988-02-19 1990-07-24 Snyder Laboratories, Inc. Process for coating polymer surfaces and coated products produced using such process
US4925698A (en) 1988-02-23 1990-05-15 Tekmat Corporation Surface modification of polymeric materials
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US4884579A (en) 1988-04-18 1989-12-05 Target Therapeutics Catheter guide wire
JPH01300958A (ja) 1988-05-31 1989-12-05 Canon Inc 表面機能性膜を有する眼内レンズ
US5079093A (en) 1988-08-09 1992-01-07 Toray Industries, Inc. Easily-slippery medical materials and a method for preparation thereof
US5067489A (en) 1988-08-16 1991-11-26 Flexmedics Corporation Flexible guide with safety tip
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US5470829A (en) 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
JPH0777720B2 (ja) * 1988-11-22 1995-08-23 工業技術院長 ウォータージェット用ノズル
EP0373237A1 (de) 1988-12-13 1990-06-20 Siemens Aktiengesellschaft Inhalationsgerät, insbesondere Taschen-Inhalationsgerät
US5091205A (en) 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
JPH03505424A (ja) 1989-04-14 1991-11-28 アゼルバイジャンスキ　ポリテフニチェスキ　インスティテュト　イメニ　チェー．イルドリマ 液状媒質の超音波霧化装置
US5080924A (en) 1989-04-24 1992-01-14 Drexel University Method of making biocompatible, surface modified materials
US5202066A (en) * 1989-04-25 1993-04-13 Idemitsu Kosan Co., Ltd. Method of plasticizing molding material and apparatus therefor
KR940005307B1 (ko) 1989-04-28 1994-06-16 또낀 코포레이션 의탄성의 형상 기억 합금을 이용하는 용이작용성 카테테르 가이드 와이어
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
EP0397130B1 (en) 1989-05-11 1995-04-19 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Medical device having highly biocompatible surface and method for manufacturing the same
US5026607A (en) 1989-06-23 1991-06-25 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US5017383A (en) 1989-08-22 1991-05-21 Taisho Pharmaceutical Co., Ltd. Method of producing fine coated pharmaceutical preparation
US5049403A (en) 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5066705A (en) 1990-01-17 1991-11-19 The Glidden Company Ambient cure protective coatings for plastic substrates
US5084315A (en) 1990-02-01 1992-01-28 Becton, Dickinson And Company Lubricious coatings, medical articles containing same and method for their preparation
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5008363A (en) 1990-03-23 1991-04-16 Union Carbide Chemicals And Plastics Technology Corporation Low temperature active aliphatic aromatic polycarbodiimides
US5107852A (en) 1990-04-02 1992-04-28 W. L. Gore & Associates, Inc. Catheter guidewire device having a covering of fluoropolymer tape
US5344426A (en) 1990-04-25 1994-09-06 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
AU7998091A (en) 1990-05-17 1991-12-10 Harbor Medical Devices, Inc. Medical device polymer
US5069217A (en) 1990-07-09 1991-12-03 Lake Region Manufacturing Co., Inc. Steerable guide wire
US5040543A (en) 1990-07-25 1991-08-20 C. R. Bard, Inc. Movable core guidewire
US5102401A (en) 1990-08-22 1992-04-07 Becton, Dickinson And Company Expandable catheter having hydrophobic surface
US5449372A (en) 1990-10-09 1995-09-12 Scimed Lifesystems, Inc. Temporary stent and methods for use and manufacture
SE467308B (sv) 1990-10-22 1992-06-29 Berol Nobel Ab Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer
SE467309B (sv) 1990-10-22 1992-06-29 Berol Nobel Ab Hydrofiliserad fast yta, foerfarande foer dess framstaellning samt medel daerfoer
US5160790A (en) 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
US5324261A (en) 1991-01-04 1994-06-28 Medtronic, Inc. Drug delivery balloon catheter with line of weakness
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5266359A (en) 1991-01-14 1993-11-30 Becton, Dickinson And Company Lubricative coating composition, article and assembly containing same and method thereof
AU1579092A (en) 1991-02-27 1992-10-06 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
DE69215722T3 (de) 1991-03-22 2001-03-08 Katsuro Tachibana Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen
US5241970A (en) 1991-05-17 1993-09-07 Wilson-Cook Medical, Inc. Papillotome/sphincterotome procedures and a wire guide specially
US5147370A (en) 1991-06-12 1992-09-15 Mcnamara Thomas O Nitinol stent for hollow body conduits
US5105010A (en) 1991-06-13 1992-04-14 Ppg Industries, Inc. Carbodiimide compounds, polymers containing same and coating compositions containing said polymers
US5213111A (en) 1991-07-10 1993-05-25 Cook Incorporated Composite wire guide construction
US5188621A (en) 1991-08-26 1993-02-23 Target Therapeutics Inc. Extendable guidewire assembly
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5234457A (en) 1991-10-09 1993-08-10 Boston Scientific Corporation Impregnated stent
CA2079417C (en) 1991-10-28 2003-01-07 Lilip Lau Expandable stents and method of making same
GB2265845B (en) 1991-11-12 1996-05-01 Medix Ltd A nebuliser and nebuliser control system
US5243996A (en) 1992-01-03 1993-09-14 Cook, Incorporated Small-diameter superelastic wire guide
JP2769261B2 (ja) * 1992-01-28 1998-06-25 三菱電機株式会社 マイクロコンピュータ
US5283063A (en) 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
CA2087132A1 (en) 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
ZA93929B (en) 1992-02-18 1993-09-10 Akzo Nv A process for the preparation of biologically active materialcontaining polymeric microcapsules.
FR2688401B1 (fr) 1992-03-12 1998-02-27 Thierry Richard Endoprothese expansible pour organe tubulaire humain ou animal, et outil de mise en place.
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5599352A (en) 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5217026A (en) 1992-04-06 1993-06-08 Kingston Technologies, Inc. Guidewires with lubricious surface and method of their production
WO1993020949A1 (en) 1992-04-09 1993-10-28 Omron Corporation Ultrasonic atomizer, ultrasonic inhalator and method of controlling same
JPH05293431A (ja) 1992-04-21 1993-11-09 Fuji Photo Film Co Ltd 塗布方法
US5382261A (en) 1992-09-01 1995-01-17 Expandable Grafts Partnership Method and apparatus for occluding vessels
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
GB9226791D0 (en) 1992-12-23 1993-02-17 Biocompatibles Ltd New materials
US5419760A (en) 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
KR960015447B1 (ko) 1993-03-16 1996-11-14 주식회사 삼양사 의료용 생분해성 고분자
WO1994021308A1 (en) 1993-03-18 1994-09-29 Cedars-Sinai Medical Center Drug incorporating and releasing polymeric coating for bioprosthesis
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
EP0711158B2 (en) 1993-07-29 2008-07-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method of treating atherosclerosis or restenosis using microtubule stabilizing agent
CH686872A5 (de) 1993-08-09 1996-07-31 Disetronic Ag Medizinisches Inhalationsgeraet.
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
GB9324250D0 (en) 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
KR0148704B1 (ko) 1994-01-10 1998-08-17 김상응 생체분해성 약물전달용 고분자
GB9415926D0 (en) 1994-08-04 1994-09-28 Biocompatibles Ltd New materials
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5576072A (en) 1995-02-01 1996-11-19 Schneider (Usa), Inc. Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel
US5702754A (en) 1995-02-22 1997-12-30 Meadox Medicals, Inc. Method of providing a substrate with a hydrophilic coating and substrates, particularly medical devices, provided with such coatings
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5869127A (en) 1995-02-22 1999-02-09 Boston Scientific Corporation Method of providing a substrate with a bio-active/biocompatible coating
EP0810845A2 (en) 1995-02-22 1997-12-10 Menlo Care Inc. Covered expanding mesh stent
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5620738A (en) 1995-06-07 1997-04-15 Union Carbide Chemicals & Plastics Technology Corporation Non-reactive lubicious coating process
US5597292A (en) 1995-06-14 1997-01-28 Alliedsignal, Inc. Piezoelectric booster pump for a braking system
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
WO1997017933A1 (en) 1995-11-15 1997-05-22 Aeropag Usa, Inc. Method of spraying a surface using ultrasonic radiation
US6720710B1 (en) 1996-01-05 2004-04-13 Berkeley Microinstruments, Inc. Micropump
US5799732A (en) 1996-01-31 1998-09-01 Schlumberger Technology Corporation Small hole retrievable perforating system for use during extreme overbalanced perforating
JP2002515786A (ja) 1996-06-28 2002-05-28 ソントラ メディカル，エル．ピー． 経皮輸送の超音波増強
US6099561A (en) 1996-10-21 2000-08-08 Inflow Dynamics, Inc. Vascular and endoluminal stents with improved coatings
EP0957980A4 (en) 1996-11-27 2000-03-29 Gen Hospital Corp DELIVERY OF COMPOUNDS BY MEANS OF IMPULSE TRANSIENT PHENOMENES
EP0971698A4 (en) 1996-12-31 2006-07-26 Nektar Therapeutics HYDROPHOBIC DRUG PROJECTED BY AEROSOL
US5785972A (en) 1997-01-10 1998-07-28 Tyler; Kathleen A. Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application
US6776792B1 (en) 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US6306166B1 (en) 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US5957975A (en) 1997-12-15 1999-09-28 The Cleveland Clinic Foundation Stent having a programmed pattern of in vivo degradation
US6104952A (en) 1998-01-07 2000-08-15 Tu; Lily Chen Devices for treating canker sores, tissues and methods thereof
WO1999034857A1 (en) 1998-01-08 1999-07-15 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6102298A (en) 1998-02-23 2000-08-15 The Procter & Gamble Company Ultrasonic spray coating application system
US6296630B1 (en) 1998-04-08 2001-10-02 Biocardia, Inc. Device and method to slow or stop the heart temporarily
US6369039B1 (en) 1998-06-30 2002-04-09 Scimed Life Sytems, Inc. High efficiency local drug delivery
JP4898991B2 (ja) 1998-08-20 2012-03-21 クック メディカル テクノロジーズ エルエルシー 被覆付植込式医療装置
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6283626B1 (en) * 1998-10-02 2001-09-04 Institute For Advanced Engineering Multiphase mixing apparatus using acoustic resonance
US6234765B1 (en) 1999-02-26 2001-05-22 Acme Widgets Research & Development, Llc Ultrasonic phase pump
US6730349B2 (en) 1999-04-19 2004-05-04 Scimed Life Systems, Inc. Mechanical and acoustical suspension coating of medical implants
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
EP1250164B1 (en) 2000-01-24 2005-11-23 Biocompatibles UK Limited Coated implants
US20040211362A1 (en) 2000-05-31 2004-10-28 Daniel Castro System for coating a stent
US6638249B1 (en) 2000-07-17 2003-10-28 Wisconsin Alumni Research Foundation Ultrasonically actuated needle pump system
US6964647B1 (en) * 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6569099B1 (en) 2001-01-12 2003-05-27 Eilaz Babaev Ultrasonic method and device for wound treatment
US6706337B2 (en) 2001-03-12 2004-03-16 Agfa Corporation Ultrasonic method for applying a coating material onto a substrate and for cleaning the coating material from the substrate
US6623444B2 (en) * 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US20030063984A1 (en) 2001-04-09 2003-04-03 George Keilman Ultrasonic pump and methods
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US6669103B2 (en) 2001-08-30 2003-12-30 Shirley Cheng Tsai Multiple horn atomizer with high frequency capability
DE10145479A1 (de) * 2001-09-14 2003-05-08 Trw Automotive Safety Sys Gmbh Verfahren zum Falten eines Gassacks für ein Fahrzeuginsassen-Rückhaltesystem sowie gefalteter Gassack
US6776352B2 (en) * 2001-11-26 2004-08-17 Kimberly-Clark Worldwide, Inc. Apparatus for controllably focusing ultrasonic acoustical energy within a liquid stream
US6743463B2 (en) 2002-03-28 2004-06-01 Scimed Life Systems, Inc. Method for spray-coating a medical device having a tubular wall such as a stent
JP2003339729A (ja) 2002-05-22 2003-12-02 Olympus Optical Co Ltd 超音波手術装置
EP1516597A4 (en) 2002-06-27 2010-11-10 Microport Medical Shanghai Co MEDICINES ELUTIONSSTENT
US7160516B2 (en) * 2002-07-30 2007-01-09 Sonics & Materials, Inc. High volume ultrasonic flow cell
US6818063B1 (en) 2002-09-24 2004-11-16 Advanced Cardiovascular Systems, Inc. Stent mandrel fixture and method for minimizing coating defects
EP1605865B1 (en) 2003-03-17 2008-12-10 ev3 Endovascular, Inc. Stent with thin film composite laminate
US7163555B2 (en) 2003-04-08 2007-01-16 Medtronic Vascular, Inc. Drug-eluting stent for controlled drug delivery
US20040215313A1 (en) 2003-04-22 2004-10-28 Peiwen Cheng Stent with sandwich type coating
US20040236399A1 (en) 2003-04-22 2004-11-25 Medtronic Vascular, Inc. Stent with improved surface adhesion
US8518097B2 (en) 2003-04-25 2013-08-27 Medtronic Vascular, Inc. Plasticized stent coatings
US7279174B2 (en) 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
US7524527B2 (en) 2003-05-19 2009-04-28 Boston Scientific Scimed, Inc. Electrostatic coating of a device
US6883729B2 (en) 2003-06-03 2005-04-26 Archimedes Technology Group, Inc. High frequency ultrasonic nebulizer for hot liquids
US7169179B2 (en) 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US20050058768A1 (en) 2003-09-16 2005-03-17 Eyal Teichman Method for coating prosthetic stents
US7060319B2 (en) 2003-09-24 2006-06-13 Boston Scientific Scimed, Inc. method for using an ultrasonic nozzle to coat a medical appliance
US7744645B2 (en) 2003-09-29 2010-06-29 Medtronic Vascular, Inc. Laminated drug-polymer coated stent with dipped and cured layers
US7318932B2 (en) 2003-09-30 2008-01-15 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US7810743B2 (en) 2006-01-23 2010-10-12 Kimberly-Clark Worldwide, Inc. Ultrasonic liquid delivery device
US7429815B2 (en) 2006-06-23 2008-09-30 Caterpillar Inc. Fuel injector having encased piezo electric actuator
US7780095B2 (en) * 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7896854B2 (en) * 2007-07-13 2011-03-01 Bacoustics, Llc Method of treating wounds by creating a therapeutic solution with ultrasonic waves
US8016208B2 (en) * 2008-02-08 2011-09-13 Bacoustics, Llc Echoing ultrasound atomization and mixing system
US7950594B2 (en) * 2008-02-11 2011-05-31 Bacoustics, Llc Mechanical and ultrasound atomization and mixing system

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108348699A (zh) * 2015-10-30 2018-07-31 强生消费者公司 无菌气溶胶雾化装置
CN108348697A (zh) * 2015-10-30 2018-07-31 强生消费者公司 无菌气溶胶雾化装置
CN108348697B (zh) * 2015-10-30 2021-09-10 强生消费者公司 无菌气溶胶雾化装置
CN114606499A (zh) * 2022-04-07 2022-06-10 燕山大学 一种表面具有微孔结构的金属及其制备方法与应用

Also Published As

Publication number Publication date
EP1915218A4 (en) 2008-09-03
KR20080040728A (ko) 2008-05-08
WO2007021427A3 (en) 2007-12-06
CA2659974A1 (en) 2007-02-22
EP1915218A2 (en) 2008-04-30
WO2007021427A2 (en) 2007-02-22
DE602006012847D1 (de) 2010-04-22
US7896539B2 (en) 2011-03-01
EP1915218B1 (en) 2010-03-10
US20080091108A1 (en) 2008-04-17
ATE460230T1 (de) 2010-03-15
JP2009504396A (ja) 2009-02-05
US20070051307A1 (en) 2007-03-08

Similar Documents

Publication Publication Date Title
CN101242907A (zh) 用于混合液体和涂覆支架的超声设备和方法
CA2659932A1 (en) Ultrasound medical stent coating method and device
US6979473B2 (en) Method for fine bore orifice spray coating of medical devices and pre-filming atomization
US20080286440A1 (en) Process for coating a substrate
US7341630B1 (en) Stent coating system
US8282980B2 (en) Stent coating method
US7896855B2 (en) Method of treating wounds by creating a therapeutic combination with ultrasonic waves
CN102597675B (zh) 通过喷射和干燥来移除溶剂而施加到医疗装置的药物洗脱涂层
US20070254091A1 (en) System and method for electrostatic-assisted spray coating of a medical device
US10105246B2 (en) Hybrid polymer stent fabricated by a non-laser cut fabrication method
JP2011500288A5 (zh)
US8397666B2 (en) Mandrel coating assembly
US20060198942A1 (en) System and method for coating a medical appliance utilizing a vibrating mesh nebulizer
US7531202B2 (en) Nozzle and method for use in coating a stent
JP2789298B2 (ja) 生体組織接着剤塗布用チューブ
WO2008042363A1 (en) Method and apparatus to disintegrate liquids having a tendency to solidify
CN201791633U (zh) 药物洗脱支架的喷涂装置
US20070160743A1 (en) Method for coating biocompatible material on a substrate
JP2013230457A (ja) ノズルおよび液体吐出システム

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1115089

Country of ref document: HK

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20080813

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1115089

Country of ref document: HK