CN101299042B

CN101299042B - Device for washing quartz crystal micro-balance chip

Info

Publication number: CN101299042B
Application number: CN200810062489A
Authority: CN
Inventors: 叶尊忠; 王婷; 应义斌; 吴坚; 王剑平; 李延斌
Original assignee: Zhejiang University ZJU
Current assignee: Zhejiang University ZJU
Priority date: 2008-06-12
Filing date: 2008-06-12
Publication date: 2012-10-03
Anticipated expiration: 2028-06-12
Also published as: CN101299042A

Abstract

The present invention discloses a device for cleaning the quartz crystal microbalance chip. An upper end surface of a lower clamp plate and a lower end surface of an upper clamp plate are respectively provided with an inserting groove with same shape with the QCM chip to be cleaned. Two U-shaped rings are respectively inserted in the upper and the lower clamp plate. Furthermore two U-shaped rings can be respectively pressed at upper side and lower side of the QCM chip. The direction of openings of two U-shaped rings is opposite with the direction of the electrode conductor or the QCM chip. The upper clamp plate and the lower clamp plate are fixed through fixing bolts and are sealed to a cleaning device. The inserting groove of the upper clamp plate near the semicircle of the U-shaped ring is provided with a fluid inlet. The lower clamp plate is provided with a fluid outlet at the part near the opening of the U-shaped ring. The fluid inlet and fluid outlet are respectively plugged with a rubber plug. The device according to the invention can realize the simultaneous cleaning to the surfaces at two sides of the chip at the same only one fluid inlet and one fluid outlet are provided. The device of the invention is not afraid of moving or shaking and can also be used for cultivating the biological material on the surface of chip. The device has the advantages of simple structure, convenient installation and operation. The wire lead of QCM chip and cleaning fluid are totally insulated in cleaning.

Description

Device for washing quartz crystal micro-balance chip

Technical field

The present invention relates to a kind of device for washing quartz crystal micro-balance chip.

Background technology

QCM (Quartz Crystal Microbalance, be called for short QCM) biology sensor be a kind of be the biology sensor of foundation with the mass change, have highly sensitive, sample and need not mark and simple operation and other advantages.QCM is applied to fields such as clinical diagnosis, environment measuring, food security gradually, has vast potential for future development.In detection, whether the QCM chip surface totally has very big influence to testing result.But still there is not special QCM chip cleaning device at present; Often directly the QCM chip is soaked in the cleaning fluid and cleans, because the special construction of QCM chip itself cleans chip surface like this; Cleaning fluid is directly contacted with lead-in wire; Cleaning fluid can corrode lead-in wire, and particularly some cleaning fluid tool corrosivity influences bigger.Even need not soak, and adopt the cleaning method that drips, also be easy to because cleaning fluid is contacted with lead-in wire, and the corrosion lead-in wire, thereby cause QCM chip detection performance influenced, the life-span shortens greatly simultaneously.

Summary of the invention

The purpose of this invention is to provide a kind of device for washing quartz crystal micro-balance chip that prevents that contact conductor is corroded.

The technical scheme that the present invention adopts is following:

Comprise top board, lower platen, two U-shaped circles and two rubber plugs; The lower platen upper surface has the QCM chip embedded groove identical with the QCM chip form that is cleaned; Have the QCM chip embedded groove identical with the top board lower surface of lower platen opposite position with the QCM chip form; Two U-shaped circles are inlaid in respectively in top board and the lower platen; And two U-shaped circles can be pressed in QCM chip both sides up and down respectively; The opening direction of two U-shaped circles and QCM chip electrode lead-in wire are in the opposite direction, and top board becomes cleaning device with lower platen through the set bolt fixing seal, has fluid intake in the QCM chip embedded groove of top board near U-shaped circle semicircle; Lower platen has fluid egress point near U-shaped circle opening part, and fluid intake and fluid egress point clog with rubber plug respectively.

Described two U-shaped loop materials are rubber, and the width of U-shaped circle is less than the QCM chip diameter that is cleaned, the contact conductor of the opening direction of U-shaped circle and QCM chip cleaning fluid and two contact conductors of keeping apart in the opposite direction.

The beneficial effect that the present invention has is:

QCM chip cleaning device of the present invention; Can under the situation of single fluid inlet and single fluid outlet, realize that the both sides chip surface cleans simultaneously, and not be afraid of and move or rock, also can be used for the cultivation of chip surface biomaterial; Simple in structure; QCM chip lead and cleaning fluid are kept apart in installation and easy to operate fully during cleaning, can be widely used in fields such as biology, chemistry, life sciences.

Description of drawings

Fig. 1 is a vertical view after the assembling of apparatus of the present invention.

Fig. 2 is the left view of Fig. 1.

Fig. 3 is the A-A sectional view of Fig. 1.

Fig. 4 is the QCM chip figure that the present invention is cleaned.

Fig. 5 is a U-shaped loop graph of the present invention.

Fig. 6 is a top board vertical view of the present invention.

Fig. 7 is a top board upward view of the present invention.

Fig. 8 is the A-A sectional view of Fig. 6.

Fig. 9 is a lower platen vertical view of the present invention.

Figure 10 is a lower platen upward view of the present invention.

Figure 11 is the A-A sectional view of Fig. 9.

Among the figure: 1, top board, 2, lower platen, 3, the QCM chip, 4,5, the U-shaped circle; 6,7, rubber plug, 8,9,10, set bolt, 101, fluid intake, 102, QCM chip embedded groove; 103,104,105, fixed orifice, 201, QCM chip embedded groove, 202, fluid egress point; 203,204,205, fixed orifice, 301,302, golden film, 303,304, contact conductor.

Embodiment

Below in conjunction with accompanying drawing and embodiment the present invention is described further.

Like Fig. 1～shown in Figure 11, the present invention includes

top board

1,4,5 and two

rubber plugs

6,7 of 2, two U-shaped circles of lower platen; Lower platen 2 upper surfaces have and the identical embedded groove 201 of QCM chip 3 shapes that is cleaned; Have the QCM chip embedded groove 102 identical with top board 1 lower surface of lower platen 2 opposite positions with QCM chip 3 shapes; And be less than or equal the height of U-shaped circle 4,5 corresponding to the groove depth of QCM chip 3 circular portions; Be greater than or equal the half the of actual QCM chip 3 contact conductor pedestals corresponding to the groove depth of QCM chip 3 contact conductor base parts; Two U-shaped circles 4,5 are inlaid in respectively in top board 1 and the lower platen 2; And two U-shaped circles 4,5 can be pressed in the QCM chip respectively, and about in the of 3 both sides, and the opening direction of two U-shaped circles 4,5 and QCM chip electrode lead-in wire are in the opposite direction, and top board 1 becomes cleaning device with lower platen 2 through the set bolt fixing seal; Be that fixed orifice 103,104,105 and the fixed orifice on lower platen 2 triangles 203,204,205 usefulness set

bolts

8,9,10 on top board 1 triangle are fixing; After device installed, QCM chip 3 both sides gold film 301,302 was respectively by two U-shaped circle 4,5 parts encirclements up and down, and the QCM chip embedded groove 102 in the top board 1 is gone into the 3 back connections of QCM chip with the QCM chip embedded groove 201 in the lower platen 2 at setting-in; Have fluid intake 101 in the embedded groove 102 of pressing plate 1 near U-shaped circle 4 semicircles; Lower platen 2 has fluid egress point 202 near U-shaped circle 5 opening parts, and fluid intake 101 has a

rubber plug

6,7 to clog the gateway respectively with fluid egress point 202.

Described two U-shaped circle 4,5 materials are rubber, and the width of U-shaped circle 4,5 is less than QCM chip 3 diameters that are cleaned, and the contact conductor of the opening direction of U-shaped circle 4,5 and QCM chip 3 is in the opposite direction, mainly in order to keep apart cleaning fluid and two contact conductors 303,304.

Application process of the present invention is following:

1, according to Fig. 1, system's wiring layout shown in Figure 3, QCM chip 3 is installed in the service sink, and clogs fluid egress point 202 with rubber plug 7.

2, at fluid intake 101, syringe may or liquid-transfering gun inject cleaning fluid, and cleaning fluid gets into QCM chip 3 upper surfaces through fluid intake 101 passages, and the groove that is communicated with through top board 1 and lower platen 2 gets into QCM chip 3 lower surfaces; Cleaning fluid clogs fluid intake 101 with rubber plug 6 after being full of QCM chip 3 upper and lower surfaces; Can artificially rock airtight service sink device gently then, cleaning fluid is flowed, cleaning performance is better.

3, after the cleaning, fluid egress point 202 is erect the service sink device down, extracts the rubber plug 7 of fluid egress point 202, and cleaning fluid just topples over out fast.

4, this QCM chip service sink device also can be used for the modification of QCM chip 3 surface biologicals or chemical material, the environmentally advantageous obstruct external environment influence of airtight modification, and good protection lead-in wire.

5, through at fluid intake 101 and fluid egress point 202 pipe laying connector and kapillaries, connect the syringe pump of promotion back and forth of outer computer control again, can realize that fluid flows on QCM chip 3 surfaces back and forth, improves and cleans or biological chemistry material modification effect.

Claims

1. a device for washing quartz crystal micro-balance chip is characterized in that: comprise top board (1), lower platen (2), two U-shaped circles (4,5) and two rubber plugs (6,7); Lower platen (2) upper surface has and the identical QCM chip embedded groove (201) of QCM chip (3) shape that is cleaned; Have the QCM chip embedded groove (102) identical with top board (1) lower surface of lower platen (2) opposite position with QCM chip (3) shape; Be less than or equal the height of two U-shaped circles (4,5) corresponding to the groove depth of QCM chip (3) circular portion; Two U-shaped circles (4,5) are inlaid in respectively in top board (1) and the lower platen (2); And two U-shaped circles (4,5) can be pressed in QCM chip (3) both sides up and down respectively; The opening direction of two U-shaped circles (4,5) and QCM chip electrode lead-in wire are in the opposite direction, and top board (1) becomes cleaning device with lower platen (2) through the set bolt fixing seal, has fluid intake (101) in the QCM chip embedded groove (102) of top board (1) near U-shaped circle (4) semicircle; Lower platen (2) has fluid egress point (202) near U-shaped circle (5) opening part, and fluid intake (101) and fluid egress point (202) use rubber plug (6,7) to clog respectively; Described two U-shaped circles (4,5) material is a rubber.