CN101301202A - Watch type non-invasive light sound blood sugar monitoring instrument - Google Patents
Watch type non-invasive light sound blood sugar monitoring instrument Download PDFInfo
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- CN101301202A CN101301202A CNA2008101069742A CN200810106974A CN101301202A CN 101301202 A CN101301202 A CN 101301202A CN A2008101069742 A CNA2008101069742 A CN A2008101069742A CN 200810106974 A CN200810106974 A CN 200810106974A CN 101301202 A CN101301202 A CN 101301202A
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Abstract
The invention relates to a watch-type non-trauma optical acoustic blood sugar monitor. A display screen, a control button, a controller, a cell and a measurement box are arranged in watch-type casing, an acoustic insulating layer, a sound absorption pad, a semiconductor laser tube, a Fourier lens, a light-transparent protection film and a hollow multi-ring array sensor are packaged in the measurement box to form a integrated coaxial confocal structure. The watch-type casing is equipped with a watchband to be wore on wrist of detector, an optical acoustic excitation source and an optical path lens system generate focused laser beam which passes through the hollow multi-ring array sensor and radiates to blood vessel of wrist to realize optical acoustic blood sugar detection of continuous A-type dynamic focusing scan and provide optical acoustic blood sugar results of multiple sites along wrist depth direction. The monitor has advantages of having small structure and simple operation, realizing real-time monitoring of optical acoustic blood sugar, having no trauma when detecting, having no need of blood supply and test paper, and avoiding cross infection and environmental influence.
Description
Technical field
The present invention relates to biomedical measurement and technical field of medical instruments, be specifically related to a kind of watch type non-invasive light sound blood sugar monitoring instrument.
Background technology
Blood sugar test still generally adopts the mediatory type means that wound or Wicresoft are arranged at present, this mode needs micro-end blood and corresponding reagent paper slightly, and the development in future direction should be the Woundless blood sugar detection technique of non-mediatory type, for example optical instruments such as optoacoustic analytic process, spectra methods, Raman spectrum analysis method, light scattering Zymography and light polarization Zymography.Also there are a lot of difficulties in current optoacoustic analytical method, and as owing to need accomplish the detection that can't harm, the energy of incident laser can not surpass threshold values, and the launching efficiency that therefore effectively improves optoacoustic is a problem that needs solution in a hurry.In addition, be to adopt solid state laser more than the optoacoustic detection as excitaton source, there is certain difficulty in the integrated and miniaturization of system.
Calendar year 2001 Z.Zhao and R.Myllyla, " Photoacoustic determination ofglucose concentration in whole blood by a near-infrared laser diode " Proc.SPIE, 4256,77-83,2001. reported the measuring method of the light sound blood sugar concentration that excites based on the near-infrared laser diode, but it is clinical that the detection method of this forward mode is difficult to be applied to, and fail to realize confocal arrangement, the sensitivity of system is very low, and the photoacoustic signal that collects needs average thousands of times.A.A.Bednov in 2003, E.V.Savateeva, A.A.Oraevsky, " Glucose monitoring in wholeblood by measuring laser-induced acoustic profiles " Proc.SPIE, 4960,21-29,2003. reported light sound blood sugar detection method based on the side direction detection mode, adopted high-power Nd:YAG laser instrument as excitaton source, the photoacoustic signal that collects needs on average hardly, but the solid state laser of large volume can't be realized real miniaturization and practicality [non-patent literature 2].And also all there is a problem in said method, owing to be that single detector is as transducing part all, photo-acoustic excitation and sensing fail to realize the coaxial confocal structure, therefore the efficient of photo-acoustic excitation and detection is not high, need more powerful solid state laser that the optoacoustic excitation energy is provided, or need thousands of signals on average just improve signal to noise ratio, and the solid state laser of large volume can't realize encouraging the integrated and miniaturization with sensing, signal averaging repeatedly greatly reduces the temporal resolution of system, forward direction and edgewise detection mode all lack the convenience of practical operation, and actual popularizing application prospect has been subjected to very big restriction.
Summary of the invention
The technical problem to be solved in the present invention provide a kind of structure small and exquisite, be easy to carry, watch type non-invasive light sound blood sugar monitoring instrument easy and simple to handle, the light sound blood sugar monitoring result in a plurality of sites of wrist depth direction can be provided simultaneously.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of watch type non-invasive light sound blood sugar monitoring instrument, it is characterized in that: be provided with display screen and control knob on the surface of shell, the bottom surface of shell is the multi-layered bonded plate, measuring box is placed on the multi-layered bonded plate, is provided with the acoustics insulating barrier and the sound absorption pad of hollow in measuring box; Top at the acoustics insulating barrier is provided with semiconductor laser tube, is provided with fourier transform lens below semiconductor laser tube, and the below of fourier transform lens is provided with light transmission protecting film and is installed in hollow multi-ring array pick off on the multi-layered bonded plate; The center of semiconductor laser tube, fourier transform lens, light transmission protecting film and hollow multi-ring array pick off all is positioned on the same axis, integrated being packaged in the measuring box, constitute incorporate coaxial confocal structure, improve investigation depth when can effectively reduce the laser energy requirement; Be provided with controller and battery in the side of measuring box, each ring of hollow multi-ring array pick off is connected with the binding post of controller respectively by lead.Described shell is a watch style, and the watchband that is worn on detected personnel's wrist is housed.Described semiconductor laser tube is the quasiconductor pulsed laser diode, is operated in the one or more wavelength of ultraviolet to the infra-red range.Described semiconductor laser tube and fourier transform lens form the photo-acoustic excitation source and the light path lens combination produces the laser beam that focuses on, and passes the hollow internal ring of light transmission protecting film and hollow multi-ring array pick off, the blood vessel in the directive wrist.Planar array that described hollow multi-ring array pick off is a hollow or concavo-convex battle array adopt piezoelectric, comprise Lithium metaniobate, composite, piezoelectric ceramics or the making of PVDF thin film; Hollow multi-ring array pick off adopts dorsad that the serial or parallel of pattern receives photoacoustic signal in real time, realizes that the light sound blood sugar of continuous A type dynamic focusing scanning is surveyed, and the light sound blood sugar result in a plurality of sites of wrist depth direction is provided.
Work process of the present invention is: under controller triggers, the semiconductor laser tube excitation produces pulse laser, its wavelength, pulsewidth and repetition rate can be selected as required, after laser energy focuses on by the light path collimated, see through protecting film and be radiated blood vessel wrist skin under, functional groups such as blood glucose absorption luminous energy excites the generation photoacoustic signal; Controller triggers multi-ring array pick off mode detection photoacoustic signal dorsad simultaneously, realizes exciting and sensing of photoacoustic signal; By the optoacoustic data that certain algorithm process collects, can realize the continuous A type dynamic focusing scanning probe of light sound blood sugar at depth direction, obtain the light sound blood sugar result in a plurality of sites of wrist depth direction.
The invention has the beneficial effects as follows:
1) the inventive method with the receiving mode dorsad of optoacoustic, excite and sensing integrated processing, effectively realized the watch style system structure of miniaturization and practicability, have structure small and exquisite, be easy to carry, easy and simple to handle, the real-time monitoring that can realize light sound blood sugar, do not have wound, need not extract blood and reagent paper is provided, avoid the advantage of the influence of cross infection and environment when detecting.
2) the present invention forms the coaxial confocal structure with photo-acoustic excitation source, light path lens combination and multi-ring array pick off, can greatly improve exciting and sensing efficient of optoacoustic, effectively reduce and improve investigation depth when laser energy requires, realize the continuous A type dynamic focusing scanning probe of light sound blood sugar, the light sound blood sugar result in a plurality of sites of wrist depth direction is provided.
3) the present invention adopts cheap semiconductor laser tube to realize the light sound blood sugar monitoring, and the cost of each assembly is lower, so the cost of single unit system is also relatively low, is easy to application.
Description of drawings
Fig. 1 is a structural upright sketch map of the present invention.
Fig. 2 is structure of the present invention (the A-A section of a Fig. 1) sketch map.
Fig. 3 is the wiring schematic diagram of multi-ring array pick off.
Fig. 4 is worn on the sketch map of wrist for the present invention.
The specific embodiment
Be described further of the present invention below in conjunction with drawings and Examples.
Embodiment: a kind of watch type non-invasive light sound blood sugar monitoring instrument, be provided with display screen 11 and control knob 18 on the surface of watch style shell 13, the bottom surface of shell 13 is a multi-layered bonded plate 12, measuring box 7 is placed on the multi-layered bonded plate 12.In measuring box 7, be provided with the acoustics insulating barrier 6 and the sound absorption pad 5 of hollow.Be provided with quasiconductor pulsed laser diode 155G4S14X at the top of acoustics insulating barrier 6, Laser Components 1, operation wavelength is 1550nm, and peak power is 45W, and pulsewidth is 150ns, and single pulse energy is about 6.75uJ, and dutycycle DF is 0.1%.Be provided with fourier transform lens 2 below quasiconductor pulsed laser diode 1, the below of fourier transform lens 2 is provided with light transmission protecting film 3 and is installed in hollow multi-ring array pick off 4 on the multi-layered bonded plate 12; The center of semiconductor laser tube 1, fourier transform lens 2, light transmission protecting film 3 and hollow multi-ring array pick off 4 all is positioned on the same axis 15, and integrated being packaged in the measuring box 7 constitutes incorporate coaxial confocal structure.Hollow multi-ring array pick off 4 is the planar array or the concavo-convex battle array of hollow, the employing piezoelectric ceramics is made, the work centre frequency is 2.5MHz, the number of ring is 6, be designed to the equally spaced planar rings battle array of the homalographic structure of hollow, ring spacing is not more than half-wavelength, and wherein the velocity of sound is decided to be 1500m/s, each ring is connected with the binding post 20 of controller 9 respectively by lead 19, realizes the sensing and the processing of photoacoustic signal.Light transmission protecting film 3 has printing opacity and water-proof function, can protect inner optics; Acoustics insulating barrier 6 is used to prevent that ultrasonic energy from reaching shell 13 and causing the reflection interference signal.Be provided with controller 9 and battery 10 in the side of measuring box 7.
Watch style shell 13 is equipped with the watchband 17 that is worn on detected personnel's wrist 8, quasiconductor pulsed laser diode 1 and fourier transform lens 2 are formed the laser beam 14 of photo-acoustic excitation source and light path lens combination generation focusing, pass the hollow internal ring of light transmission protecting film 3 and hollow multi-ring array pick off 4, the blood vessel 16 in the directive wrist 8; Hollow multi-ring array pick off 4 adopts dorsad that the serial or parallel of pattern receives photoacoustic signal in real time, realizes that the light sound blood sugar of continuous A type dynamic focusing scanning is surveyed, and the light sound blood sugar result in a plurality of sites of wrist depth direction is provided.
Claims (5)
1. watch type non-invasive light sound blood sugar monitoring instrument, it is characterized in that: be provided with display screen (11) and control knob (18) on the surface of shell (13), the bottom surface of shell (13) is multi-layered bonded plate (12), measuring box (7) is placed on the multi-layered bonded plate (12), is provided with the acoustics insulating barrier (6) and the sound absorption pad (5) of hollow in measuring box (7); Be provided with semiconductor laser tube (1) at the top of acoustics insulating barrier (6), be provided with fourier transform lens (2) in the below of semiconductor laser tube (1), the below of fourier transform lens (2) is provided with light transmission protecting film (3) and is installed in hollow multi-ring array pick off (4) on the multi-layered bonded plate (12); The center of semiconductor laser tube (1), fourier transform lens (2), light transmission protecting film (3) and hollow multi-ring array pick off (4) all is positioned on the same axis (15), and integrated being packaged in the measuring box (7) constitutes incorporate coaxial confocal structure; Be provided with controller (9) and battery (10) in the side of measuring box (7), each ring of hollow multi-ring array pick off (4) is connected with the binding post (20) of controller (9) respectively by lead (19); Hollow multi-ring array pick off (4) adopts pattern reception photoacoustic signal dorsad, realizes that the light sound blood sugar of continuous A type dynamic focusing scanning is surveyed, and the light sound blood sugar result in wrist (8) a plurality of sites of depth direction is provided.
2. watch type non-invasive light sound blood sugar monitoring instrument according to claim 1 is characterized in that: described shell (13) is a watch style, and the watchband (17) that is worn on detected personnel's wrist (8) is housed.
3. watch type non-invasive light sound blood sugar monitoring instrument according to claim 1 is characterized in that: described semiconductor laser tube (1) is the quasiconductor pulsed laser diode, is operated in the one or more wavelength of ultraviolet to the infra-red range.
4. watch type non-invasive light sound blood sugar monitoring instrument according to claim 1 is characterized in that: described hollow multi-ring array pick off (4) is the planar array of hollow or concavo-convex battle array.
5. watch type non-invasive light sound blood sugar monitoring instrument according to claim 1; it is characterized in that: described semiconductor laser tube (1) and fourier transform lens (2) form the photo-acoustic excitation source and the light path lens combination produces the laser beam (14) that focuses on; pass the hollow internal ring of light transmission protecting film (3) and hollow multi-ring array pick off (4), the blood vessel (16) in the directive wrist (8).
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| CNB2008101069742A CN100558297C (en) | 2008-07-03 | 2008-07-03 | Watch type non-invasive light sound blood sugar monitoring instrument |
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| CNB2008101069742A CN100558297C (en) | 2008-07-03 | 2008-07-03 | Watch type non-invasive light sound blood sugar monitoring instrument |
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Cited By (15)
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| CN102621068A (en) * | 2012-02-26 | 2012-08-01 | 曾吕明 | Portable real-time opto-acoustic imaging system |
| CN103403627A (en) * | 2010-11-01 | 2013-11-20 | 耐克国际有限公司 | Wearable device assembly having athletic functionality |
| CN103892804A (en) * | 2014-03-21 | 2014-07-02 | 辛勤 | Wrist-type device used for health monitoring |
| CN104236863A (en) * | 2014-09-28 | 2014-12-24 | 广州视源电子科技股份有限公司 | Optical performance test method |
| CN104771181A (en) * | 2015-04-16 | 2015-07-15 | 桂林电子科技大学 | Reflecting type noninvasive blood glucose detector |
| US9259615B2 (en) | 2011-11-01 | 2016-02-16 | Nike, Inc. | Wearable device assembly having athletic functionality and streak tracking |
| US9474955B2 (en) | 2010-11-01 | 2016-10-25 | Nike, Inc. | Wearable device assembly having athletic functionality |
| US9720443B2 (en) | 2013-03-15 | 2017-08-01 | Nike, Inc. | Wearable device assembly having athletic functionality |
| CN104093358B (en) * | 2011-12-12 | 2017-09-08 | 迈德维特科学有限公司 | Method and apparatus for detecting hypoglycemic episodes |
| US10234827B2 (en) | 2006-05-22 | 2019-03-19 | Nike, Inc. | Watch display using light sources with a translucent cover |
| CN109875572A (en) * | 2018-11-09 | 2019-06-14 | 唐庆圆 | A kind of physiological parameter measurement mechanism and method |
| US10444791B2 (en) | 2010-11-01 | 2019-10-15 | Nike, Inc. | Wearable device assembly having athletic functionality |
| CN112370607A (en) * | 2020-12-13 | 2021-02-19 | 李兴阳 | Spectrum online blood glucose analyzer and insulin pump control method |
| CN112914538A (en) * | 2021-03-29 | 2021-06-08 | 重庆科技学院 | Blood vessel blood flow volume acquisition device and method |
| CN116138771A (en) * | 2023-04-18 | 2023-05-23 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6405069B1 (en) * | 1996-01-31 | 2002-06-11 | Board Of Regents, The University Of Texas System | Time-resolved optoacoustic method and system for noninvasive monitoring of glucose |
| CN201211189Y (en) * | 2008-07-03 | 2009-03-25 | 江西科技师范学院 | Watch type no-wound optical acoustic blood-sugar monitoring instrument |
-
2008
- 2008-07-03 CN CNB2008101069742A patent/CN100558297C/en not_active Expired - Fee Related
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| US10234827B2 (en) | 2006-05-22 | 2019-03-19 | Nike, Inc. | Watch display using light sources with a translucent cover |
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| US9539486B2 (en) | 2010-11-01 | 2017-01-10 | Nike, Inc. | Wearable device assembly having athletic functionality |
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| US11735308B2 (en) | 2010-11-01 | 2023-08-22 | Nike, Inc. | Wearable device assembly having athletic functionality and milestone tracking |
| US11495341B2 (en) | 2010-11-01 | 2022-11-08 | Nike, Inc. | Wearable device assembly having athletic functionality and milestone tracking |
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| US10064571B2 (en) | 2011-12-12 | 2018-09-04 | Medvet Science Pty Ltd | Method and apparatus for detecting the onset of hypoglycaemia |
| CN104093358B (en) * | 2011-12-12 | 2017-09-08 | 迈德维特科学有限公司 | Method and apparatus for detecting hypoglycemic episodes |
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| CN104771181A (en) * | 2015-04-16 | 2015-07-15 | 桂林电子科技大学 | Reflecting type noninvasive blood glucose detector |
| CN109875572A (en) * | 2018-11-09 | 2019-06-14 | 唐庆圆 | A kind of physiological parameter measurement mechanism and method |
| CN112370607A (en) * | 2020-12-13 | 2021-02-19 | 李兴阳 | Spectrum online blood glucose analyzer and insulin pump control method |
| CN112370607B (en) * | 2020-12-13 | 2022-08-05 | 李兴阳 | Insulin pump therapeutic instrument |
| CN112914538A (en) * | 2021-03-29 | 2021-06-08 | 重庆科技学院 | Blood vessel blood flow volume acquisition device and method |
| CN116138771A (en) * | 2023-04-18 | 2023-05-23 | 江西科技师范大学 | Energy correction method for multispectral blood glucose photoacoustic detection |
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