CN101443072A - 双侧肾神经调制的方法和装置 - Google Patents

双侧肾神经调制的方法和装置 Download PDF

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CN101443072A
CN101443072A CNA2007800150219A CN200780015021A CN101443072A CN 101443072 A CN101443072 A CN 101443072A CN A2007800150219 A CNA2007800150219 A CN A2007800150219A CN 200780015021 A CN200780015021 A CN 200780015021A CN 101443072 A CN101443072 A CN 101443072A
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CN101443072B (zh
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丹尼丝·德马瑞斯
汉森·Ⅲ·吉福德
马克·迪姆
道格拉斯·萨顿
霍华德·R·莱文
马克·盖尔芬德
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Medtronic Adian LLC
Medtronic Ardian Luxembourg SARL
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Abstract

本发明提供了用于双侧肾神经调制的方法和装置，例如，通过脉冲电场，通过刺激电场，通过局部化的药物递送，通过高频超声波，通过热技术等。这样的神经调制可以完成不可逆的电穿孔或电融合，坏死和/或程序性细胞死亡的诱导，基因表达的改变，动作电位衰减或阻滞，细胞因子上调的改变和靶点神经纤维中其它条件的改变。在一些实施方案中，神经调制应用到对肾功能有贡献的神经纤维上。在一些实施方案中，这样的神经调制以双侧方式进行。当与单侧进行的肾神经调制相比时，即，当与在神经支配单肾的神经组织上进行的肾神经调制相比时，双侧肾神经调制可以在一些患者中提供提高的治疗作用。

Description

双侧肾神经调制的方法和装置
相关申请的交叉参考
本申请是下列同时待审的美国专利申请的每一申请的部分继续：
(1)美国专利申请号10/408,665，其于2003年4月8日提交(于2003年11月20日作为美国专利公布2003/0216792公布)，其要求于2003年1月29日提交的美国临时专利申请号60/442,970；于2002年10月3日提交的60/415,575；和于2002年4月8日提交的60/370,190的利益。
(2)美国专利申请号11/133,925，其于2005年5月20日提交，其是于2004年7月28日提交的美国专利申请号10/900,199(现在是美国专利号6,978,174)的继续，美国专利申请号10/900,199是于2003年4月8日提交的美国专利申请号10/408,665的部分继续。
(3)美国专利申请号11/189,563，其于2005年7月25日提交，其是于2005年5月13日提交的美国专利申请号11/129,765的部分继续，美国专利申请号11/129,765要求于2004年10月5日提交的美国临时专利申请号60/616,254；和于2004年11月2日提交的60/624,793的利益。
(4)美国专利申请号11/266,933，其于2005年11月4日提交。
(5)美国专利申请号11/363,867，其于2006年2月27日提交，题目为通过血管内-到-外途径的脉冲电场神经调制的方法和装置(Methods andApparatus for Pulsed Electric Field Neuromodulation Via an Intra-To-Extravascular Approach)(律师记录号57856.8010US1)，其(a)要求于2005年12月29日提交的题目为通过血管内-到-外途径的脉冲电场神经调制的方法和装置(Methods and Apparatus for Pulsed Electric Field NeuromodulationVia an Intra-To-Extra vascular Approach)的美国临时申请号60/813,589(律师记录号57856.8010US，并且最初以美国申请号11/324,188提交)的利益，并且(b)是于2005年7月25日提交的美国专利申请号11/189,563，和于2005年11月4日提交的美国专利申请号11/266,933的每一申请的部分继续。
所有前述申请、公布和专利都通过引用完全结合于本申请。
通过引用结合
所有在本说明书中提及的公布和专利申请都如同单个公布或专利申请专门地或单独地指示通过引用结合一样通过引用同等程度地结合于此。
技术领域
本发明涉及神经调制的方法和装置。在一些实施方案中，本发明涉及实现双肾神经调制的方法和装置。
背景技术
充血性心力衰竭(“CHF”)是在心脏受到损伤并且减少流到机体器官中的血流时发生的病况。如果血流充分减少，那么肾功能将改变，这导致流体滞留，异常的激素分泌和增加的血管收缩。这些结果增加心脏的工作负荷，并且进一步减少心脏泵血通过肾脏和循环系统的能力。
据信，肾脏的逐渐减少的灌注是使得CHF下行盘旋永续的主要非心脏因素。此外，流体负担和由这些生理变化导致的相关临床症状导致额外的的医院许可、很坏的生活质量和卫生保健系统的额外成本。
除了它们在CHF进展中的作用之外，肾脏在慢性肾衰竭(“CRF”)、晚期肾病(“ESRD”)、高血压(病理性高血压)和其它心-肾疾病的发展中起重要作用。肾脏的功能可以在3个主要方面进行总结：过滤血液和排泄由机体代谢产生的废物；调节盐、水、电解质和酸-碱平衡；并且分泌激素以维持重要器官的血流。在没有正确功能的肾脏情况下，患者将患有水分滞留、减少的尿流和废物毒素在血液和机体中的累积。这些病症由减少的肾功能或肾衰竭(renal failure)导致，并且据信这些病症增加心脏工作负担。在CHF患者中，当由于弱功能性肾脏引起流体滞留和血液毒素积累时，肾衰竭将使得心脏进一步恶化。
已经在动物模型中确定，心脏衰竭病况导致肾脏的异常高的交感神经激活。肾脏交感神经活性的增加导致水分和钠从机体的去除减少，以及增加的肾素分泌。增加的肾素分泌导致供应肾脏的血管的血管收缩，这引起减少的肾血流。交感肾神经活性的减小，例如，通过去神经作用，可能逆转这些过程。
申请人先前已经描述了通过对肾功能有贡献的神经纤维施加脉冲电场而治疗肾紊乱的方法和装置。参见，例如，申请人于2005年5月13日提交的同时待审的美国专利申请系列号11/129,765，和于2005年7月25日提交的系列号11/189,563，二者都通过引用完全结合于此。脉冲电场(“PEF”)可以发动肾神经调制，例如，去神经作用，例如，通过不可逆的电穿孔或通过电融合进行。PEF可以由放置在血管内、血管外、血管内-到-外或它们的组合的装置中输送。描述了用于实现肾神经调制的其它的方法和装置，例如，通过局部化的药物递送(诸如通过药物泵或输注导管)或通过使用刺激电场等，例如，在于2003年4月8日共同所有的和同时待审的美国专利申请系列号10/408,665中，和美国专利号6,978,174中描述，二者通过引用完全结合于此。
当用于本文时，电融合包括通过暴露于电场诱导的相邻细胞的融合。用于电融合目的的靶点相邻细胞之间的接触可以以各种方式实现，包括，例如，通过介电电泳。在组织中，所述靶点细胞可以是已经接触的，由此促进电融合。
当用于本文时，电穿孔和电渗透是操作细胞膜或细胞内装置的方法。例如，细胞膜的多孔性可以通过，例如，短的、高压脉冲跨越细胞膜诱导足够的电压而增加。细胞膜中多孔性的程度(例如，孔的尺寸和数量)和作用的持续时间(例如，暂时的或持久的)是多种变量的函数，诸如场强、脉冲宽度、工作周期(duty cycle)、电场方向、细胞类型或尺寸、和/或其它参数。
当相对低强度的电场或相对短的脉冲宽度的终止时，细胞膜孔通常是自发关闭的(本文定义为“可逆的电穿孔”)。然而，每种细胞或细胞类型具有临界阈值，高于该临界阈值孔不会关闭，以致孔的形成不再是可逆的；这一结果定义为“不可逆的电穿孔”，“不可逆的击穿”或“不可逆的损伤”。在这一点上，细胞膜破裂，和/或发生由高多孔性引起的不可逆的化学不平衡。这样高的多孔性可能是单个大孔和/或多个更小的孔的结果。
使用血管内PEF系统治疗肾病症的潜在的挑战是选择性电穿孔靶点细胞而不影响其它细胞。例如，可以理想地不可逆地电穿孔沿着或接近肾血管的肾神经细胞，但是可能不理想地损伤组成血管的平滑肌细胞。结果，过于激进的PEF治疗疗程可能持久地损伤肾血管，但是过于保守的PEF治疗疗程可能不会获得需要的肾神经调制。
申请人先前描述了用于下列的方法和装置：监测组织阻抗或传导率以确定脉冲电场治疗的作用，例如，确定电穿孔的程度和/或其不可逆性的程度。参见，例如，申请人于2005年9月23日提交的同时待审的美国专利申请系列号11/233,814，其通过引用完全结合于此。组织的脉冲电场电穿孔引起组织阻抗的减少和组织传导率的增加。如果诱导的电穿孔是可逆的，那么在停止所述脉冲电场时，组织阻抗和传导率应该接近基线水平。然而，如果电穿孔是不可逆的，在终止脉冲电场后，阻抗和传导率变化应该持续。因此，监测靶点和/或非靶点组织的阻抗和传导率可以用来确定电穿孔的发作和确定电穿孔的类型或程度。此外，监测数据可以用于一个或多个手工的或自动的反馈环来控制电穿孔。
本发明将理想地提供实现双肾神经调制的方法和装置。
概述
本发明提供神经调制的方法和装置，例如，通过脉冲电场(“PEF”)，通过刺激电场，通过局部化药物递送，通过高频超声波，通过热技术，它们的组合等。这样的神经调制可以，例如，实现不可逆的电穿孔或电融合，坏死和/或程序性细胞死亡的诱导，基因表达的改变，动作电位阻断或衰减，细胞因子上调的改变以及靶点神经纤维中其它条件的改变。在一些患者中，当将本发明的神经调制方法和装置用于肾神经和/或其它对肾神经功能有贡献的神经纤维时，申请人相信由神经调制诱导的神经调制作用可能导致增加的尿输出，减少的血浆肾素水平，减少的组织(例如，肾)和/或尿儿茶酚胺(例如，去甲肾上腺素)，增加的尿钠排泄，和/或受到控制的血压。此外，申请人相信这些或其它改变可以预防或治疗充血性心力衰竭、高血压、急性心肌梗死、晚期肾病、造影剂肾病(contrast nephropathy)、其它肾脏系统疾病、和/或其它肾或心-肾异常。本文所述的方法和装置可以用来调制传出或传入神经信号，以及传出和传入神经信号的组合。
肾神经调制优选地以双侧的形式进行，以便调制对右肾和左肾的肾功能有贡献的神经纤维。当与单侧进行的肾神经调制相比时，即，当与在神经支配单一肾的神经组织上进行的肾神经调制相比时，双侧肾神经调制可以在一些患者中提供提高的治疗作用。在一些实施方案中，可以实现对右肾和左肾功能都有贡献的神经纤维的同时调制。在另外的或备选的实施方案中，这样的右和左神经纤维的调制可以是顺序的。当需要时，双侧肾神经调制可以是连续的或间歇的。
当使用电场时，当需要时，电场参数可以改变或以任何组合而组合。这样的参数可以包括，但不限于，电压、场强、脉冲宽度、脉冲持续时间、脉冲的形状、脉冲的数目和/或脉冲之间的时间间隔(例如，工作周期)等。例如，当使用脉冲电场时，适宜的场强可以高达约10,000V/cm，并且适宜的脉冲宽度可以高达约1秒。例如，适宜的脉冲波形形状包括AC波形、正弦曲线波、余弦波、正弦和余弦波的组合、DC波形、DC-偏移AC波形、RF波形、方波、梯形波、指数衰减波、或它们的组合等。场包括至少一个脉冲，并且在许多应用中，场包括多个脉冲。例如，适宜的脉冲时间间隔包括小于约10秒的间隔。这些参数作为适当的实例提供，决不应该认为是限制。
附图简述
在结合附图考虑下述详述时，本发明的一些实施方案将是显而易见的，在附图中相同的参照字母始终指相同的部分，并且，在附图中：
图1是说明人肾解剖的示意图。
图2是显示相对于肾动脉的肾神经的位置的示意性等比例详图。
图3A和3B是分别说明用于选择性影响肾神经的电场的取向的示意性等比例图和端视图。
图4是说明肾神经调制的血管外方法和装置的实施例的部分剖面地示意性侧视图。
图5A和5B是分别说明用于肾神经调制的血管内和血管内-到-外的方法和装置的部分剖面地示意性侧视图。
图6A-6H是说明使用本发明的装置，说明使用图5A的装置实现双侧肾神经调制的方法的部分剖面地示意性侧视图。
图7A和7B是说明使用图5A装置的实施方案实现同时的双侧肾神经调制的方法的部分剖面地示意性侧视图。
图8是说明使用图4装置的备选实施方案实现同时的双侧肾神经调制的方法的部分剖面地示意性侧视图。
图9是说明通过局部化药物递送实现双侧肾神经调制的方法和装置的实施例的示意图。
详述
A.概述
本发明涉及神经调制的方法和装置，例如，去神经作用。在一些实施方案中，本发明提供实现双侧肾神经调制的方法和装置。当与单侧进行的肾神经调制相比时，即，当与在神经支配单一肾的神经组织上进行的肾神经调制相比时，双侧肾神经调制可以在一些患者中提供提高的治疗作用。在一些实施方案中，可以实现对右肾和左肾功能两者都有贡献的神经纤维的同时调制。在另外的或备选的实施方案中，这样的右和左神经纤维的调制可以是顺序的。当需要时，双侧肾神经调制可以是连续的或间歇的。
本发明的方法和装置可以用来调制对肾功能有贡献的神经纤维，并且可以利用实现需要的神经调制的任何适当的神经调制技术。例如，可以使用任何适当的电信号或场参数，例如，实现需要的神经调制(例如，电穿孔作用)的任何电场。备选地或另外地，神经调制可以通过局部化递送神经调制剂或药物实现。为了更好地理解本发明的装置的结构和使用这样的装置进行双侧肾神经调制的方法，检验人体肾脏解剖是指导性的。
B.神经调制方法的选择实施方案
现在参考图1，人肾脏解剖包括通过肾动脉RA供应有氧血的肾脏K，肾动脉RA通过腹部主动脉AA连接到心脏。去氧血液通过肾静脉RV和下腔静脉IVC从肾脏流到心脏。图2更详细地图示肾脏解剖的部分。更具体地，肾脏解剖还包括沿着通常在动脉外膜内的肾动脉RA的纵向维度L而纵向延伸的肾神经RN。肾动脉RA具有平滑肌细胞SMC，其环绕动脉圆周并且围绕动脉的角轴θ盘旋。因此，肾动脉的平滑肌细胞具有横断肾动脉的纵向维度(即不平行)延伸的纵向或较长维度。肾神经和平滑肌细胞的纵向维度的不重合(misalignment)定义为“细胞不重合”。
参考图3A和3B，肾神经和平滑肌细胞的细胞不重合可以用来选择性地影响肾神经细胞，所述受影响的肾神经细胞对平滑肌细胞具有减小的作用。更具体地，由于更大的细胞需要更低的电场强度来超过细胞膜不可逆的阈值电压或用于不可逆电穿孔的能量，所以，本发明的电极的实施方案可以设置成将由所述电极产生的至少部分电场沿着或者靠近要影响的细胞的较长维度排列。在具体的实施方案中，所述装置具有这样的电极，即，所述电极被设置成产生沿着或者靠近肾动脉RA的纵向维度L排列的电场，以影响肾神经RN。通过排列电场，以便所述场优先沿着细胞的纵向方面，而不是细胞的直径或径向方面排列，可以使用更低的场强来影响靶点神经细胞，例如，使靶点细胞坏死或融合，以诱导程序性细胞死亡，以改变基因表达，以衰减或阻断动作电位，以改变细胞因子上调和/或以诱导其它适当的过程。预计这减少输送到系统的总能量，并且减轻对电场中非靶点细胞的作用。
类似地，关于神经细胞的较长维度，在靶点神经之上或之下的组织的纵向或较长的维度是垂直的或另外离轴的(off-axis)(例如，横截的)。因此，除了沿着靶点细胞的纵向或较长维度排列脉冲电场(“PEF”)之外，PEF可以沿着非靶点细胞的横向或较短维度传播(即，以致PEF至少部分沿着非靶点平滑肌细胞SMC排列之外传播)。因此，如在图3A和3B中所示，施加具有通常沿着肾动脉RA的纵向维度L排列的传播线Li的PEF，预计优先在靶点肾神经RN细胞中引起电穿孔(例如，不可逆的电穿孔)、电融合、或其它神经调制，而不会过度影响非靶点动脉平滑肌细胞SMC。脉冲电场可以以沿着肾动脉纵轴的单个平面传播，或者可以以沿着从0°-360°范围的任何角度的扇形(segment)θ的纵向方向传播。
位于肾动脉壁内和/或接近肾动脉壁的PEF系统可以传播具有纵向部分的电场，所述纵向部分沿着在肾神经RN和血管壁平滑肌细胞SMC区域的动脉的纵向维度排列，以致动脉壁保持至少基本上是完好的，而外部的神经细胞被破坏、融合或另外影响。监测元件可以用来评估在肾神经和/或在平滑肌细胞中诱导的例如电穿孔的程度，以及调整PEF参数以获得需要的作用。
C.神经调制的系统和另外方法的示例性实施方案
参考图4和5，描述了PEF系统和方法的实施例。图4显示一个血管外脉冲电场装置200的实施方案，该装置包括一个或多个设置成将脉冲电场输送到肾神经纤维以实现肾神经调制作用的电极。图4的装置被设置成临时的血管外放置；然而，应该理解，可以另外或备选地使用部分或完全可植入的血管外装置。申请人先前已经描述了血管外PEF系统，例如，在于2005年6月25日提交的同时待审的美国专利申请系列号11/189,563中，其通过引用完全结合于此。
在图4中，装置200包括具有探针210的腹腔镜或经皮PEF系统，例如在CT或射线成像的引导下，设置所述探针210插入在沿着肾动脉或静脉或肾门和/或Gerota筋膜内的肾神经供应的轨道的邻近处。设置至少一个电极212用于通过探针210输送到治疗位点，用以输送脉冲电场治疗。例如，电极212可以安装在导管上，并且通过电线211电耦合到脉冲发生器50。在一个备选的实施方案中，探针210的远端部分具有一个电极212，并且所述探针可以具有电连接器，以将所述探针耦合到脉冲发生器50，用于将PEF输送至一个或多个电极212。
脉冲电场发生器50位于患者的外部。发生器、以及本文描述的任何PEF-输送电极实施方案，可以与本发明的任何实施方案一起使用，用以输送具有需要的场参数的PEF。应该理解，即使每个实施方案没有清楚地显示或描述发生器，下文所述实施方案的PEF-输送电极可以电连接至发生器。
电极212可以是彼此电独立的单个电极，具有共同连接的触点的节段电极，或者连续电极。例如，节段电极可以通过提供配合到电极上的开槽导管而形成，或者通过电连接一系列的单个电极而形成。单个电极或电极212的组可以设置成提供双极信号。电极212可以动态指定成促进任何电极之间和/或任何电极与外部接地垫板(ground pad)之间的单极和/或双极能量输送。这样一种接地垫板可以，例如，在外部附着到患者皮肤上，例如，患者的腿或胁腹上。在图4中，电极212包括双极电极对。探针210和电极212可以与临床上用于脉冲的RF神经阻滞的标准针或套管针型相似。备选地，装置200可以包括柔软的和/或用户定制设计的探针，以用于本文所述的肾应用。
在图4中，经皮探针210已经通过经皮通路位点P推进到患者肾动脉RA的邻近处中。该探针穿过患者的Gerota筋膜F，并且电极212通过探针推进到位置并且沿着患者动脉和筋膜之间的环形空间。一旦准确地定位，脉冲电场治疗可以穿过双极电极212而应用到靶点神经纤维。这样的PEF治疗可以，例如，通过靶点神经纤维细胞的不可逆电穿孔至少部分将由该靶点神经纤维神经支配的肾脏去神经。电极212任选地还可以用来监测PEF治疗的电穿孔作用。治疗后，装置200可以从患者移除以终止程序。
现在参考图5A，描述了血管内PEF系统的实施方案。申请人先前已经描述了血管内PEF系统，例如，在于2005年5月13日提交的同时待审的美国专利申请系列号11/129,765中，其通过引用完全结合于此。图5A的实施方案包括装置300，该装置300包括具有定心元件304(例如，气球、可扩张的金属丝篮、其它机械扩张器，等)的导管302、沿着导管的轴放置的轴电极306a和306b、和任选地在所述定心元件304区域沿着导管轴放置的辐射透不过的标记308。电极306a-b，例如，可以这样排列，以致电极306a接近定心元件304的近端，并且电极306b接近定心元件304的远端。电极306电耦合到脉冲发生器50(参见图4)，所述脉冲发生器50放置在患者外部，用于输送PEF治疗。
定心元件304可以包括阻抗改变的元件，其在PEF治疗过程中改变电极306a和306b之间的阻抗，例如，以更好地引导PEF治疗穿过血管壁。这可以减小获得需要的肾神经调制的应用电压。申请人先前已经描述了阻抗改变元件的应用，例如，在于2005年11月4日提交的同时待审的美国专利申请系列号11/266,993中，其通过引用完全结合于此。当定心元件304包括可膨胀的气球时，该气球可以作为电极306的定心元件和作为阻抗改变的电绝缘体，以引导所输送的电场穿过电极，例如，以引导电场进入或穿过血管壁，从而调制靶点神经纤维。由元件304提供的电绝缘可以减少应用电压或在靶点纤维获得需要的场强所必需的脉冲电场的其它参数的大小。
电极306可以是单个电极(即，独立的触点)、具有共同连接的接触器的节段电极、或单一的连续电极。此外，电极306可以设置成提供双极信号，或电极306可以一起使用或单独地与单独的患者接地垫板联合一起用于单极应用。作为备选方案，或者除了将电极306沿着导管302的中轴放置以外，如在图5A中，电极306可以附着到定心元件304上，以便它们接触肾动脉RA的壁。在这样的改变中，电极可以，例如，固定在内表面上、外表面或至少部分包埋在所述定心元件的壁内。所述电极任选地可以用来检测PEF治疗的作用，如下文所述。由于可以理想地减少或最小化在输送PEF治疗过程中的PEF输送电极和血管壁之间的物理接触，例如，减少损伤壁的电势，电极306可以，例如，包括附着到导管轴上的第一套电极，用于输送PEF治疗，并且所述装置还可以包括第二套电极，其附着到定心元件304上，用于监测通过电极306输送的PEF治疗的作用。
在使用中，以低档输送构型，例如，通过引导导管，可以将导管302输送至肾动脉RA，如所示，或者可以将其输送至肾静脉，或输送至邻近对肾功能有贡献的肾组织的任何其它血管中。一旦放置在肾血管内部，任选的定心元件304可以扩张成与血管内壁接触。然后可以通过PEF发生器50产生脉冲电场，通过导管302转移到电极306，并且通过电极306穿过动脉壁输送。PEF治疗调制对肾功能有贡献的神经纤维的活性，例如，将由所述神经纤维神经支配的肾脏至少部分去神经。例如，这可以通过在神经细胞中不可逆的电穿孔、电融合和/或程序性细胞死亡的诱导作用而获得。在许多应用中，电极这样排列，以便脉冲电场沿着肾动脉的纵向维度排列，从而促进对肾神经的调制，而对非靶点平滑肌细胞或其它细胞几乎没有作用。
除了血管外和血管内PEF系统之外，可以提供血管内-到-外的PEF系统，其具有这样的电极，该电极被输送到血管内位置，然后在输送PEF治疗之前至少部分通过/穿过血管壁到血管外位置。与完全血管内放置电极相比较，血管内-到-外放置电极可以在PEF治疗过程中将电极放置在更接近靶点神经纤维处。申请人先前已经描述了血管内-到-外PEF系统，例如，在于2005年12月29日提交的同时待审的美国专利申请系列号11/324,188(以下“‘188申请”)中，其通过引用完全结合于此。
参考图5B，显示了先前在‘188申请中描述的血管内-到-外(“ITEV”)PEF系统的一个实施方案。ITEV PEF系统320包括导管322，其具有(a)在近侧端口324终止的多个近端电极腔(lumen)，(b)在远侧端口326终止的多个远端电极腔，和(c)导线腔323。导管322优选地包括等数目的近端和远端电极腔和侧端口。系统320还包括可以穿过近端电极腔推进的近端针电极328，和远侧端口324，以及可以穿过远端电极腔推进的远端针电极329，和远侧端口326。
导管322包括任选的可扩张的定心元件330，其可以包括膨胀的气球或可扩张的篮或笼。在使用时，定心元件330可以在展开针电极328和329之前扩张，以便将导管322放置在患者血管内(例如，在肾动脉RA内)的中央。将导管322放置在中央预计促进将所有针电极输送至患者血管内部/外部的需要的深度(例如，将所有针电极输送至大约相同的深度)。在图5B中，举例说明的定心元件330放置在近侧端口324和远侧端口326之间，即，在近端和远端电极的输送位置之间。然而，应该理解，另外或备选地，定心元件330可以放置在不同位置或沿着导管长度的多个位置(例如，在邻近侧端口324的位置和/或在远离侧端口326的位置)。
如在图5B中所举例说明，导管322可以通过腔323经由导线(未显示)推进到患者血管内的治疗位点(例如，患者肾动脉RA内的治疗位点)。在血管内输送过程中，电极328和329可以这样放置，以便它们非绝缘的和尖锐的远端区域分别放置在近端和远端腔内。一旦放置在治疗位点，医学执业者可以通过它们位于患者外部的近端区域推进电极。这样的推进引起电极328和329的远端区域分别离开侧端口324和326，并且穿透患者血管壁，以致电极通过ITEV途径在血管外放置。
近端电极328可以与PEF发生器50连接作为活性电极，并且远端电极329可以作为返回电极(return electrode)。以这种方式，近端和远端电极形成双极电极对，其将PEF治疗沿着患者血管的纵轴或纵向方向排列。显而易见地，远端电极329备选地可以包括活性电极，并且近端电极328可以包括返回电极。此外，近端和/或远端电极可以包括活性电极和返回电极二者。当需要时，可以使用活性电极和远端电极的任何组合。
当电极328和329与PEF发生器50连接并且血管外放置时，并且在定心元件330任选地扩张的情况下，PEF治疗可以继续进行获得需要的神经调制。在完成PEF治疗后，电极可以缩回到近端和远端腔内，并且定心元件330可以折叠以取回。然后，ITEV PEF系统320可以从患者移出以结束程序。另外地或者备选地，所述系统可以重新放置，以在另一个治疗位点提供PEF治疗，例如，提供双侧肾神经调制。
预计本发明用于神经调制的PEF治疗，以及其它方法和装置(例如，刺激电场、局部化药物递送、高频超声波、热技术等)，不管血管外、血管内、血管内-到-外递送或它们的组合，例如，可以实现不可逆的电穿孔或电融合、坏死和/或诱导程序性细胞死亡、改变基因表达、动作电位阻滞或衰减、细胞因子上调和靶点神经纤维中其它条件的改变。在一些患者中，当将这样的神经调制方法和装置用于肾神经和/或对肾神经功能有贡献的其它神经纤维时，申请人相信由所述神经调制诱导的神经调制作用可能导致增加的尿输出、减少的血浆肾素水平、减少的组织(例如，肾)和/或尿儿茶酚胺(例如，去甲肾上腺素)、增加的尿钠排泄、和/或得到控制的血压。此外，申请人相信这些或其它改变可以在数月的期间，有力地多达6个月或以上，预防或治疗充血性心脏衰竭、高血压、急性心肌梗死、晚期肾病、造影剂肾病、其它肾脏系统疾病、和/或其它肾或心-肾异常。该时间期间可以足以允许机体痊愈；例如，该期间可以减少在急性心肌梗死后CHF发作的危险，由此减少对随后的再治疗的需要。备选地，当症状再发生时，或以有规则预定的时间间隔，患者可以回到医师那里进行重复治疗。本文所述的方法和装置可以用来调制传出或传入神经信号，以及传出和传入神经信号的组合。优选地实现按照本发明的神经调制，而没有完全物理切断，即，没有完全切断靶点神经纤维。然而，应该理解，这样的神经调制可以功能性切断神经纤维，即使所述纤维可以不是完全物理切断的。本文示例性所述的装置和方法设置成经皮使用。这样的经皮使用可以是腔内的、腹腔镜的、它们的组合等。
参考图4和5的上述装置另外可以用于定量PEF治疗的功效、程度或细胞选择性，以监测和/或控制该治疗。当脉冲电场开始电穿孔时，被电穿孔组织的阻抗开始减小，并且该组织的传导率开始增加。如果电穿孔是可逆的，那么在终止PEF时，组织电参数将恢复或近似于基线值。然而，如果电穿孔是不可逆的，那么在终止PEF后，组织参数的变化将持续。这些现象可以用来监测PEF治疗的开始和效果。例如，可以使用，例如，传导率测量或阻抗测量，诸如电阻抗X线断层摄影(“EIT”)和/或其它电阻抗/传导率测量，如电阻抗或传导率指数，直接监测电穿孔。这样的电穿孔检测数据任选地可以用在一个或多个反馈环中，以控制PEF治疗的输送。
为了收集需要的监测数据，另外的监测电极任选地可以邻近被监测组织提供。在这样的监测电极之间的距离优选地将在治疗输送之前确定，并且用来从阻抗或电导测量确定传导率。对于本发明的目的，阻抗的虚部可以被忽略，以便阻抗可以定义为电压除以电流，而电导可以定义为阻抗的倒数(即，电流除以电压)，并且传导率可以定义为每单位距离的电导。申请人先前已经在于2005年9月23日提交的同时待审的美国专利申请系列号11/233,814中描述了监测PEF治疗的方法和装置，以及示例性的PEF波形，该申请通过引用完全结合于此。
尽管图4和5的实施方案示例性地包括双极装置，但是应该理解，备选地可以使用单极装置。例如，可以将活性单极电极血管内、血管外或血管内-到-外地放置在对肾功能有贡献的靶点神经纤维附近。返回电极接地垫板可以附着到患者的外部。最后，PEF治疗可以在体内单极电极和接地垫板之间输送，以实现需要的肾神经调制。单极装置另外可以用于双侧肾神经调制。
可以理想地实现双侧肾神经调制。当与单侧进行的肾神经调制相比时，即，与在神经支配单一肾脏的神经组织上进行的肾神经调制相比较时，双侧神经调制可以在一些患者中提高治疗作用。例如，双侧肾神经调制可以进一步减少CHF、高血压、急性心肌梗死、造影剂肾病、肾病和/或其它心-肾疾病的临床症状。图6A-6H举例说明使用图5A的血管内装置进行双侧肾神经调制的方法的阶段。然而，应该理解，这样的双侧神经调制备选地可以使用图4的血管外装置、使用图5B的血管内-到-外装置而实现，或使用任何备选的血管内装置、血管外装置、血管内-到-外装置(包括单极装置)或它们的组合而实现。
如在图6A和6E中所示，引导导管GC和导线G可以推进到患者左肾动脉LRA或右肾动脉RRA内部或附近。在图6A中，导线示例性地放置在右肾动脉RRA内，但是应该理解，在图6A-6H中举例说明的双侧肾神经调制的顺序可以备选地颠倒。另外或备选地，双侧肾神经调制可以同时在对肾功能有贡献的右和左神经纤维上进行，如在图7-9中，而不是顺序地进行，如在图6中。
在导线和引导导管放置在右肾动脉中的情况下，装置300的导管302可以经由导线并且通过引导导管推进到动脉内的位置。如在图6B中所示，导管302的任选定心元件304在将导管输送到肾动脉的过程中处于减小的输送构型。在图6C中，当导管正确放置用于PEF治疗时，元件304任选地可以扩张成与血管壁接触，并且导线G可以从治疗区缩回，例如，可以从患者中移出，或者可以更近地放置在患者的大动脉内。
元件304的扩张可以使电极306位于血管内的中央和/或可以改变电极之间的阻抗。在将装置300按需要放置和展开时，PEF治疗可以以双极方式穿过电极306输送，以实现在对右肾功能有贡献的神经纤维中的肾神经调制，例如，至少部分实现右肾的肾去神经作用。如由传播线Li所示，脉冲电场可以沿着肾动脉RA的纵向维度排列，并且可以穿过血管壁。预测脉冲电场的排列和传播路径优先调制靶点肾神经的细胞，而不会不适当地影响非靶点动脉平滑肌细胞。
如在图6D中所示，在完成PEF治疗后，元件304可以折叠回到缩小的输送模式，并且导管302可以从右肾动脉RRA缩回，例如，缩回到在患者腹部大动脉内的引导导管GC内的位置。类似地，引导导管GC可以缩回到患者大动脉内的位置。缩回的引导导管可以重新放置，例如，旋转，以便其远端出口通常沿着左肾动脉LRA排列。然后导线G可以通过导管302和引导导管GC重新推进到左肾动脉LRA内的位置，如在图6E中所示(显而易见地，当接近任一个肾动脉时，任选地可以颠倒导线和引导导管的推进顺序)。
接着，导管302可以经由导线并且通过引导导管重新推进到左肾动脉内的位置中，如在图6F中所示。在图6G中，当导管正确放置用于PEF治疗时，元件304任选地可以扩张成与血管壁接触，并且导线G可以缩回到接近治疗位点的位置。然后可以以双极方式穿过电极306输送PEF治疗，例如，沿着传播线Li，以在对左肾功能有贡献的神经纤维中实现肾神经调制，例如，至少部分实现左肾的肾去神经。如在图6H中所示，在完成双侧PEF治疗后，元件304可以折叠回到缩小的输送模式，并且导管302，以及导线G和引导导管GC，可以从患者移出，以完成双侧肾神经调制程序。
如先前讨论，双侧肾神经调制任选地可以在对右肾和左肾功能有贡献的纤维上同时进行。图7A和7B举例说明用于进行同时的双侧肾神经调制的装置300的实施方案。在图7A的实施方案中，装置300包括双PEF治疗导管302，以及双导线G和引导导管GC。一个导管302放置在右肾动脉RRA内部，并且另一个导管302放置在左肾动脉LRA内部。在导管302放置在右肾和左肾动脉中的情况下，可以通过导管302同时输送PEF治疗，以获得同时的双侧肾神经调制，示例性地通过血管内途径进行。
在一个实施例中，可以在患者的右和左股动脉上产生分开的动脉解剖位点，用于经皮输送两个导管302。备选地，两个导管302可以通过单一的股动脉入口位点输送，通过双引导导管或通过单引导导管。图7B举例说明使用单个动脉解剖入口位点进行同时双侧肾神经调制的装置300的实施例。在图7B的实例中，两个导管302通过常规分成两部分的引导导管GC’进行输送，所述引导导管GC’具有分成两部分的远端区域，用于将导管302同时输送到右肾和左肾动脉。然后可以进行同时(或顺序)的双侧PEF治疗。
图8举例说明用于同时双侧肾神经调制的其它方法和装置。在图8中，血管外装置200的实施方案包括双探针210和电极212。所述电极放置在左肾动脉LRA和右肾动脉RRA的附近。PEF治疗可以通过电极212同时输送，以实现同时的双侧肾神经调制，通过血管外途径举例说明。
显而易见地，血管内-到-外装置备选地可以用于双侧肾神经调制。这样的双侧肾神经调制可以顺序地、同时地或它们的组合地进行。例如，图5B的ITEV PEF系统320可以用于双侧肾神经调制。
还可以使用用于实现肾神经调制的其它方法和装置，例如，通过局部化的药物递送(诸如通过药物泵或输注导管)或通过使用刺激电场，等。这样的方法和装置的实例先前已经，例如，描述在于2003年4月8日提交的共同所有的和同时待审的美国专利申请系列号10/408,665中，和在美国专利号6,978,174中，这两个专利都通过引用全部结合于此。
图9显示用于通过局部化药物递送实现双侧肾神经调制的方法和装置的一个实施例。在图9中，药物储器400，示意性地是可植入的药物泵，已经植入在患者内。药物递送导管402a和402b与所述药物储器连接，并且分别延伸到右肾动脉RRA和左肾动脉LRA的附近，用于递送能够调制对肾功能有贡献的神经纤维的一种或多种神经调制剂或药物。通过导管402a和402b递送药剂可以获得双侧肾神经调制。当需要时，通过导管402a和402b的这样的药物递送可以同时或顺序地进行，以及连续或间歇地进行，以分别提供同时的或顺序的，连续的或间歇的肾神经调制。
在图9装置的备选实施方案中，导管402a和402b可以仅仅临时放置在需要的位置，例如，用于从外部药物储器如注射器紧急递送一种或多种神经调制剂。这样的临时放置可以包括，例如，导管的血管内、血管外和/或血管内-到-外放置。在另一个备选的实施方案中，药物储器400可以用可植入的神经刺激器或起搏器型装置放置，并且导管402可以用耦合到神经刺激器的电导线代替，用于向靶点肾纤维输送电场，诸如脉冲电场或刺激电场。在另一个备选实施方案中，电技术可以与一种或多种神经调制剂的递送组合，以实现所需要的双侧肾神经调制。
尽管上文描述了本发明的优选的示例性变体，但是对于本领域的技术人员显而易见地可以对其进行各种改变和改进，而不背离本发明。例如，尽管主要描述了变体与脉冲电场组合使用，但是应该理解，当需要时可以输送任何其它电场，包括刺激电场或神经阻滞电场，并且可以使用任何其它备选的神经调制技术，诸如神经调制剂或药物的局部化递送。在附上的权利要求中意欲覆盖落入本发明真正的精神和范围内的所有这样的改变和改进。

Claims (60)

1.用于双侧肾神经调制的方法，所述方法包括：
调制对患者的第一个肾的肾功能有贡献的至少第一神经纤维；和
调制对患者的第二个肾的肾功能有贡献的至少第二神经纤维，由此实现双侧肾神经调制。
2.权利要求1的方法，其中调制对患者的第一个肾的肾功能有贡献的第一神经纤维还包括调制对右肾功能有贡献的右神经纤维，和
其中调制对患者的第二个肾的肾功能有贡献的第二神经纤维还包括调制对左肾功能有贡献的左神经纤维。
3.权利要求1的方法，其中调制对患者的第一个肾的肾功能有贡献的第一神经纤维还包括调制对左肾功能有贡献的左神经纤维，和
其中调制对患者的第二个肾的肾功能有贡献的第二神经纤维还包括调制对右肾功能有贡献的右神经纤维。
4.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括同时调制所述第一和第二神经纤维。
5.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括顺序地调制所述第一和第二神经纤维。
6.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括通过放置在患者的肾血管系统内部的装置来调制所述第一神经纤维和调制所述第二神经纤维。
7.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括通过放置在患者的肾血管系统外部的装置来调制所述第一神经纤维和调制所述第二神经纤维。
8.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括通过放置在邻近患者的肾血管系统处的装置来调制所述第一神经纤维和调制所述第二神经纤维。
9.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括通过放置在患者的肾血管系统内部并且具有从血管外传递的神经调制元件的装置来调制所述第一神经纤维和调制所述第二神经纤维。
10.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括通过电场来调制所述第一和第二神经纤维。
11.权利要求10的方法，其中通过电场调制所述第一和第二神经纤维还包括将所述第一和第二神经纤维暴露于脉冲电场。
12.权利要求10的方法，其中通过电场调制所述第一和第二神经纤维还包括将所述第一和第二神经纤维暴露于刺激电场。
13.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括将神经调制剂递送到所述第一和第二神经纤维。
14.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括将所述第一和第二肾至少部分去神经。
15.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括在所述第一和第二神经纤维中诱导选自由下列各项组成的组中的一种作用：不可逆的电穿孔、电融合、坏死、程序性细胞死亡、基因表达改变、动作电位衰减、动作电位阻滞、细胞因子上调改变、以及它们的组合。
16.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括连续地调制所述第一和第二神经纤维。
17.权利要求1的方法，其中调制所述第一神经纤维和调制所述第二神经纤维还包括间歇地调制所述第一和第二神经纤维。
18.用于双侧肾神经调制的装置，所述装置包括：
第一场施加器，所述第一场施加器设置成放置在邻近对右肾功能有贡献的至少第一神经纤维处；
第二场施加器，所述第二场施加器设置成放置在邻近对左肾功能有贡献的至少第二神经纤维处；和
场发生器，所述场发生器耦合到所述第一和第二场施加器，
其中所述场发生器设置成为所述第一场施加器提供第一信号和为所述第二场施加器提供第二信号。
19.权利要求18的装置，其中所述第一场施加器和所述第二场施加器包括血管内场施加器，其设置成放置在患者的肾血管系统内部。
20.权利要求18的装置，其中所述第一场施加器和所述第二场施加器包括血管外场施加器，所述血管外场施加器设置成放置在邻近患者的肾血管系统处的外部。
21.权利要求18的装置，其中所述第一场施加器和所述第二场施加器包括血管内-到-外场施加器，所述血管内-到-外场施加器设置成通过血管内-到-外途径的血管外放置。
22.权利要求18的装置，其中所述第一场施加器和所述第二场施加器包括这样的场施加器，所述场施加器设置成下列放置的组合：在患者肾血管系统内部的放置，在邻近患者的肾血管系统外部的放置或通过血管内-到-外途径的血管外放置。
23.权利要求18的装置，其中所述场发生器还包括脉冲电场发生器。
24.权利要求18的装置，其中所述第一场施加器和所述第二场施加器包括设置成放置在邻近所述第一和第二神经纤维处的电极，并且其中所述电极耦合到所述场发生器，用于将电场输送到所述第一和第二神经纤维。
25.权利要求24的装置，其中所述第一场施加器和所述第二场施加器包括第一双极电极对和第二双极电极对。
26.权利要求24的装置，其中所述第一场施加器和所述第二场施加器包括第一单极单极和第二单极电极，所述装置还包括至少一个接地垫板，所述接地垫板设置成外部附着到所述患者。
27.权利要求24的装置，其中所述第一场施加器包括双极电极对，并且所述第二场施加器包括单极电极，所述装置还包括接地垫板，所述接地垫板设置成外部附着到所述患者。
28.权利要求24的装置，其中所述第一场施加器包括单极电极，并且所述第二场施加器包括双极电极对，所述装置还包括接地垫板，所述接地垫板设置成外部附着到所述患者。
29.权利要求18的装置，其中所述场发生器设置成同时对所述第一场施加器提供第一信号和对所述第二场施加器提供第二信号。
30.权利要求18的装置，其中所述场发生器设置成顺序地为所述第一场施加器提供第一信号和为所述第二场施加器提供第二信号。
31.权利要求18的装置，其中所述场发生器设置成连续地为所述第一场施加器提供第一信号和为所述第二场施加器提供第二信号。
32.权利要求18的装置，其中所述场发生器设置成间歇地为所述第一场施加器提供第一信号和为所述第二场施加器提供第二信号。
33.一种用于双侧肾神经调制的方法，所述方法包括：
调制对患者的右肾功能有贡献的神经纤维；和
调制对所述患者的左肾功能有贡献的神经纤维。
34.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括将所述患者的右肾和左肾去神经。
35.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括在所述神经纤维中诱导选自由下列各项组成的组的作用：不可逆的电穿孔、电融合、坏死、程序性细胞死亡、基因表达改变、动作电位衰减、动作电位阻滞、细胞因子上调改变、以及它们的组合。
36.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括：
将调制装置放置在所述患者的右肾和左肾血管系统内，和
用所述调制装置调制所述神经纤维。
37.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括：
将调制装置放置在所述患者的右肾和左肾血管系统附近，和
用所述调制装置调制所述神经纤维。
38.权利要求37的方法，其中将调制装置放置在患者的右肾和左肾血管系统附近还包括将在患者内部的所述调制装置放置在所述肾血管系统外部。
39.权利要求38的方法，其中将在所述患者内部的所述调制装置放置在肾血管系统外部还包括将在患者内部的所述调制装置通过血管内-到-外途径放置在肾血管系统外部。
40.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括对所述右和左神经纤维施加电场。
41.权利要求40的方法，其中对所述右和左神经纤维施加电场还包括对所述右和左神经纤维施加脉冲电场。
42.权利要求40的方法，其中对所述右和左神经纤维施加电场还包括对所述右和左神经纤维施加刺激电场。
43.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括将神经调制剂递送到所述右和左神经纤维。
44.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括同时调制对右肾和左肾功有贡献的神经纤维。
45.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括顺序地调制对右肾和左肾功有贡献的神经纤维。
46.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括连续地调制对右肾和左肾功有贡献的神经纤维。
47.权利要求33的方法，其中调制对右肾和左肾功能有贡献的神经纤维还包括间歇地调制对右肾和左肾功有贡献的神经纤维。
48.用于双侧肾神经调制的装置，所述装置包括：
第一药物递送元件，所述第一药物递送元件设置成放置在邻近对右肾功能有贡献的第一神经纤维处；
第二药物递送元件，所述第二药物递送元件设置成放置在邻近对左肾功能有贡献的第二神经纤维处；和
包括神经调制剂的药物储器，所述药物储器耦合到所述第一和第二药物递送元件，
其中所述药物储器设置成将所述神经调制剂递送到所述第一药物递送元件和所述第二药物递送元件。
49.权利要求48的装置，其中所述药物储器包括可植入的药物泵。
50.权利要求48的装置，其中所述药物储器包括外部药物储器。
51.权利要求48的装置，其中所述药物储器设置成将所述神经调制剂同时递送至所述第一药物递送元件和所述第二药物递送元件。
52.权利要求48的装置，其中所述药物储器设置成将所述神经调制剂顺序地递送至所述第一药物递送元件和所述第二药物递送元件。
53.权利要求48的装置，其中所述药物储器设置成将所述神经调制剂连续地递送至所述第一药物递送元件和所述第二药物递送元件。
54.权利要求48的装置，其中所述药物储器设置成将所述神经调制剂间歇地递送至所述第一药物递送元件和所述第二药物递送元件。
55.一种用于同时双侧肾神经调制的装置，所述装置包括：
第一刺激导管，所述第一刺激导管设置成放置在至少邻近与第一肾脏相关的第一肾动脉处，所述第一刺激导管具有至少一个第一电极；
第二刺激导管，所述第二刺激导管设置成放置在至少邻近与第二肾脏相关的第二肾动脉处，所述第二刺激导管具有至少一个第二电极；和
场发生器，所述场发生器连接到所述第一电极和所述第二电极。
56.权利要求55的装置，所述装置还包括具有腔和分为两部分的远端区域的引导导管，所述引导导管设置成放置在血管内，并且其中所述第一刺激导管在所述腔内并且设置成将所述分成两部分的远端区域的一侧突出到所述第一肾动脉中，并且所述第二刺激导管在所述腔内并且设置成将所述分成两部分的远端区域的相对一侧突出到所述第二肾动脉内。
57.权利要求55的装置，所述装置还包括设置成放置在血管内的双引导导管，所述双引导导管包括第一引导导管和第二引导导管，并且其中所述第一刺激导管是在所述第一引导导管内，并且所述第二刺激导管是在所述第二引导导管内。
58.权利要求55的装置，其中所述第一导管设置成放置在所述第一肾动脉的外部，并且所述第二导管设置成放置在所述第二肾动脉的外部。
59.权利要求55的装置，其中所述第一电极设置成接触所述第一肾动脉的内壁，并且所述第二电极设置成接触所述第二肾动脉的内壁。
60.权利要求55的装置，其中所述第一电极设置成通过所述第一肾动脉壁，并且所述第二电极设置成通过所述第二肾动脉壁。
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104125799A (zh) * 2011-11-07 2014-10-29 美敦力阿迪安卢森堡有限责任公司 血管内神经监测装置及相关的系统和方法
CN106377312A (zh) * 2010-10-25 2017-02-08 美敦力Af卢森堡有限责任公司 用于肾神经调节的微波导管设备、系统和方法
US9814873B2 (en) 2002-04-08 2017-11-14 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
CN107802341A (zh) * 2013-03-15 2018-03-16 美敦力Af卢森堡有限责任公司 用于神经调制治疗的专门化的设备、系统和方法
CN107847743A (zh) * 2015-07-21 2018-03-27 皇家飞利浦有限公司 刺激肾神经的系统
CN108348748A (zh) * 2015-09-04 2018-07-31 赛恩神经刺激有限责任公司 用于具有包调制的神经刺激的系统、设备和方法
CN111248996A (zh) * 2019-12-09 2020-06-09 韦伯斯特生物官能(以色列)有限公司 用于补偿细胞尺寸和取向的定向的不可逆电穿孔(ire)脉冲

Families Citing this family (289)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US8016823B2 (en) 2003-01-18 2011-09-13 Tsunami Medtech, Llc Medical instrument and method of use
US9433457B2 (en) 2000-12-09 2016-09-06 Tsunami Medtech, Llc Medical instruments and techniques for thermally-mediated therapies
US8444636B2 (en) 2001-12-07 2013-05-21 Tsunami Medtech, Llc Medical instrument and method of use
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7756583B2 (en) * 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7620451B2 (en) * 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US6907884B2 (en) 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US8808284B2 (en) * 2008-09-26 2014-08-19 Relievant Medsystems, Inc. Systems for navigating an instrument through bone
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US8613744B2 (en) 2002-09-30 2013-12-24 Relievant Medsystems, Inc. Systems and methods for navigating an instrument through bone
US7258690B2 (en) 2003-03-28 2007-08-21 Relievant Medsystems, Inc. Windowed thermal ablation probe
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
AU2004285412A1 (en) 2003-09-12 2005-05-12 Minnow Medical, Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US8579892B2 (en) 2003-10-07 2013-11-12 Tsunami Medtech, Llc Medical system and method of use
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
JP2006135377A (ja) * 2004-11-02 2006-05-25 Toshiba Corp 半導体装置
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
AU2007212587B2 (en) 2006-02-03 2012-07-12 Synecor, Llc Intravascular device for neuromodulation
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
EP2092957B2 (en) * 2006-06-28 2019-11-20 Medtronic Ardian Luxembourg S.à.r.l. Systems for thermally-induced renal neuromodulation
EP2455034B1 (en) 2006-10-18 2017-07-19 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
CA2666661C (en) 2006-10-18 2015-01-20 Minnow Medical, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
JP5479901B2 (ja) 2006-10-18 2014-04-23 べシックス・バスキュラー・インコーポレイテッド 身体組織に対する所望の温度作用の誘発
US20080119907A1 (en) * 2006-11-22 2008-05-22 Cardiac Pacemakers, Inc. Renal function modulation via application of electrical energy stimulation
US8216217B2 (en) 2007-08-23 2012-07-10 Aegea Medical, Inc. Uterine therapy device and method
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US9924992B2 (en) 2008-02-20 2018-03-27 Tsunami Medtech, Llc Medical system and method of use
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
US8721632B2 (en) 2008-09-09 2014-05-13 Tsunami Medtech, Llc Methods for delivering energy into a target tissue of a body
US8768469B2 (en) 2008-08-08 2014-07-01 Enteromedics Inc. Systems for regulation of blood pressure and heart rate
AU2009296474B2 (en) 2008-09-26 2015-07-02 Relievant Medsystems, Inc. Systems and methods for navigating an instrument through bone
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
US20100114244A1 (en) * 2008-10-31 2010-05-06 Medtronic, Inc. Electrical renal autonomic blockade
US8386053B2 (en) * 2008-10-31 2013-02-26 Medtronic, Inc. Subclavian ansae stimulation
US7910193B2 (en) * 2008-11-10 2011-03-22 Mkp Structural Design Associates, Inc. Three-dimensional auxetic structures and applications thereof
CN104068933B (zh) 2008-11-11 2017-03-15 施菲姆德控股有限责任公司 小外形的电极组件
US9795442B2 (en) 2008-11-11 2017-10-24 Shifamed Holdings, Llc Ablation catheters
CN102271603A (zh) 2008-11-17 2011-12-07 明诺医学股份有限公司 得知或未得知组织形态的选择性能量积累
US8725249B2 (en) 2008-12-09 2014-05-13 Nephera Ltd. Stimulation of the urinary system
US8923970B2 (en) 2008-12-09 2014-12-30 Nephera Ltd. Stimulation of the urinary system
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) * 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
WO2010080886A1 (en) 2009-01-09 2010-07-15 Recor Medical, Inc. Methods and apparatus for treatment of mitral valve in insufficiency
AU2010204957B2 (en) * 2009-01-14 2014-02-27 Cardiac Pacemakers, Inc. Promoting diuresis and natriuresis by applying electric field
US11284931B2 (en) 2009-02-03 2022-03-29 Tsunami Medtech, Llc Medical systems and methods for ablating and absorbing tissue
NZ619320A (en) * 2009-04-22 2015-08-28 Mercator Medsystems Inc Use of guanethidine for treating hypertension by local vascular delivery
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
CN104548316B (zh) 2009-06-24 2018-01-26 施菲姆德控股有限责任公司 可转向医疗输送装置及使用方法
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
CN102596320B (zh) 2009-10-30 2016-09-07 瑞蔻医药有限公司 通过经皮超声波去肾神经治疗高血压的方法和装置
CN102686147B (zh) 2009-11-05 2016-01-20 格雷特巴奇有限公司 波导神经接口装置
US8900223B2 (en) 2009-11-06 2014-12-02 Tsunami Medtech, Llc Tissue ablation systems and methods of use
US20110112400A1 (en) * 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US9161801B2 (en) 2009-12-30 2015-10-20 Tsunami Medtech, Llc Medical system and method of use
EP2525715A4 (en) * 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY
CA2787062C (en) 2010-01-26 2017-07-11 Michael A. Evans Methods, devices, and agents for denervation
US20110208173A1 (en) * 2010-02-24 2011-08-25 Medtronic Vascular, Inc. Methods for Treating sleep apnea via renal Denervation
US8556891B2 (en) 2010-03-03 2013-10-15 Medtronic Ablation Frontiers Llc Variable-output radiofrequency ablation power supply
WO2011119857A2 (en) 2010-03-24 2011-09-29 Shifamed, Llc Intravascular tissue disruption
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
JP5792802B2 (ja) 2010-05-12 2015-10-14 シファメド・ホールディングス・エルエルシー 低い外形の電極組立体
US9655677B2 (en) 2010-05-12 2017-05-23 Shifamed Holdings, Llc Ablation catheters including a balloon and electrodes
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
EP2600784B1 (en) 2010-08-05 2021-12-29 Medtronic Ireland Manufacturing Unlimited Company Cryoablation apparatuses, systems, and methods for renal neuromodulation
US9943353B2 (en) 2013-03-15 2018-04-17 Tsunami Medtech, Llc Medical system and method of use
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
EP3449856B1 (en) 2010-10-25 2023-06-28 Medtronic Ardian Luxembourg S.à.r.l. Device for evaluation and feedback of neuromodulation treatment
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
WO2012061164A1 (en) 2010-10-25 2012-05-10 Kevin Mauch Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods
US20120158104A1 (en) 2010-10-26 2012-06-21 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
WO2012064864A1 (en) 2010-11-09 2012-05-18 Aegea Medical Inc. Positioning method and apparatus for delivering vapor to the uterus
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
AU2011328921B2 (en) 2010-11-17 2015-07-09 Medtronic Af Luxembourg S.A.R.L. Therapeutic renal neuromodulation for treating dyspnea and associated systems and methods
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US20140221964A1 (en) * 2011-03-27 2014-08-07 Yong-Fu Xiao Systems and methods for local drug delivery to kidneys
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
CN103930061B (zh) 2011-04-25 2016-09-14 美敦力阿迪安卢森堡有限责任公司 用于限制导管壁低温消融的有关低温球囊限制部署的装置及方法
JP6527329B2 (ja) 2011-05-03 2019-06-05 シファメド・ホールディングス・エルエルシー 操縦可能な送達シース
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
WO2013016203A1 (en) 2011-07-22 2013-01-31 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9820811B2 (en) 2011-08-26 2017-11-21 Symap Medical (Suzhou), Ltd System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same
JP6188159B2 (ja) 2011-08-26 2017-08-30 サイマップ ホールディング リミテッド 動脈壁を支配する機能的神経を位置決し、識別するためのシステムおよび方法ならびにそのカテーテル
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9662060B2 (en) 2011-10-07 2017-05-30 Aegea Medical Inc. Integrity testing method and apparatus for delivering vapor to the uterus
EP2765942B1 (en) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
BR112014009634A2 (pt) 2011-10-19 2017-05-09 Mercator Medsystems Inc preparação e agente terapêutico
EP2775948B1 (en) 2011-11-08 2018-04-04 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
EP2779929A1 (en) 2011-11-15 2014-09-24 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9192766B2 (en) 2011-12-02 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and devices for treatment of polycystic kidney disease
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
WO2013096913A2 (en) 2011-12-23 2013-06-27 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
WO2013101772A1 (en) 2011-12-30 2013-07-04 Relievant Medsystems, Inc. Systems and methods for treating back pain
EP2809399B1 (en) 2012-01-30 2023-04-19 Auris Health, Inc. Tissue necrosis apparatus
CN104254367A (zh) 2012-03-07 2014-12-31 美敦力阿迪安卢森堡有限公司 肾神经的选择性调制
AU2013230886B2 (en) 2012-03-08 2015-10-01 Medtronic Af Luxembourg S.A.R.L. Renal neuromodulation methods and systems for treatment of hyperaldosteronism
AU2013230906A1 (en) 2012-03-08 2014-09-18 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of sexual dysfunction
WO2013134733A2 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Biomarker sampling in the context of neuromodulation devices and associated systems and methods
US9750568B2 (en) 2012-03-08 2017-09-05 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
AU2013230893B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the management of pain
US11013549B2 (en) 2012-03-08 2021-05-25 Medtronic Ardian Luxembourg S.A.R.L. Gastrointestinal neuromodulation and associated systems and methods
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
US8961550B2 (en) 2012-04-17 2015-02-24 Indian Wells Medical, Inc. Steerable endoluminal punch
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
WO2013162722A1 (en) 2012-04-27 2013-10-31 Medtronic Ardian Luxembourg Sarl Methods and devices for localized disease treatment by ablation
US9943354B2 (en) 2012-04-27 2018-04-17 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized inhibition of inflammation by ablation
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
US20150088113A1 (en) 2012-04-27 2015-03-26 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices for renal neuromodulation and associated systems and methods
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
BR112014028131A2 (pt) 2012-05-11 2017-06-27 Medtronic Ardian Luxembourg aparelho de cateter, sistema de neuromodulação renal, e, método para realizar neuromodulação renal
US8951296B2 (en) 2012-06-29 2015-02-10 Medtronic Ardian Luxembourg S.A.R.L. Devices and methods for photodynamically modulating neural function in a human
US9381063B2 (en) 2012-07-13 2016-07-05 Magnetecs Inc. Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
US8612022B1 (en) 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
EP2895095A2 (en) 2012-09-17 2015-07-22 Boston Scientific Scimed, Inc. Self-positioning electrode system and method for renal nerve modulation
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
US10398464B2 (en) 2012-09-21 2019-09-03 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
JP6074051B2 (ja) 2012-10-10 2017-02-01 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 血管内神経変調システム及び医療用デバイス
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
WO2014066432A2 (en) 2012-10-22 2014-05-01 Medtronic Ardian Luxembourg Sarl Catheters with enhanced flexibility and associated devices, systems, and methods
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US10945787B2 (en) 2012-10-29 2021-03-16 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US10736656B2 (en) 2012-10-29 2020-08-11 Ablative Solutions Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US9554849B2 (en) 2012-10-29 2017-01-31 Ablative Solutions, Inc. Transvascular method of treating hypertension
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10881458B2 (en) 2012-10-29 2021-01-05 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
CN105263431A (zh) * 2012-11-02 2016-01-20 纽敦力公司 用于多种疾病治疗的化学消融制剂和方法
WO2016070032A1 (en) 2014-10-30 2016-05-06 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US10537375B2 (en) 2015-04-24 2020-01-21 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
EP2914186B1 (en) 2012-11-05 2019-03-13 Relievant Medsystems, Inc. Systems for creating curved paths through bone and modulating nerves within the bone
CN104902836B (zh) 2012-11-05 2017-08-08 毕达哥拉斯医疗有限公司 受控组织消融
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
EP3799931A1 (en) 2013-03-14 2021-04-07 ReCor Medical, Inc. Ultrasound-based neuromodulation system
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
AU2014233354B2 (en) 2013-03-15 2017-01-12 Medtronic Af Luxembourg S.A.R.L. Controlled neuromodulation systems and methods of use
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
US9066726B2 (en) 2013-03-15 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode apposition judgment using pressure elements
CN110141177B (zh) 2013-04-08 2021-11-23 阿帕玛医疗公司 消融导管
US10349824B2 (en) 2013-04-08 2019-07-16 Apama Medical, Inc. Tissue mapping and visualization systems
US10098694B2 (en) 2013-04-08 2018-10-16 Apama Medical, Inc. Tissue ablation and monitoring thereof
US10548663B2 (en) 2013-05-18 2020-02-04 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods
US9943365B2 (en) 2013-06-21 2018-04-17 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
JP2016524949A (ja) 2013-06-21 2016-08-22 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 回転可能シャフトを有する腎神経アブレーション用医療装置
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3019106A1 (en) 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
US10660698B2 (en) 2013-07-11 2020-05-26 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
EP3049007B1 (en) 2013-07-19 2019-06-12 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US10695124B2 (en) 2013-07-22 2020-06-30 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
WO2015085162A1 (en) 2013-12-05 2015-06-11 Rfemb Holdings, Llc Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb)
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
JP6159888B2 (ja) 2013-08-22 2017-07-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経変調バルーンへの接着性を向上させたフレキシブル回路
US9339332B2 (en) 2013-08-30 2016-05-17 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods
US9326816B2 (en) 2013-08-30 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
US9138578B2 (en) 2013-09-10 2015-09-22 Medtronic Ardian Luxembourg S.A.R.L. Endovascular catheters with tuned control members and associated systems and methods
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
WO2015057521A1 (en) 2013-10-14 2015-04-23 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
EP3057520A1 (en) 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
JP6259099B2 (ja) 2013-10-18 2018-01-10 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 可撓性を備える導電性ワイヤを備えるバルーン・カテーテル、並びに関連する使用および製造方法
US10433902B2 (en) 2013-10-23 2019-10-08 Medtronic Ardian Luxembourg S.A.R.L. Current control methods and systems
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US9931046B2 (en) 2013-10-25 2018-04-03 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US10517666B2 (en) 2013-10-25 2019-12-31 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
CN105658163B (zh) 2013-10-25 2020-08-18 波士顿科学国际有限公司 去神经柔性电路中的嵌入式热电偶
JP6322402B2 (ja) * 2013-12-06 2018-05-09 株式会社グッドマン ガイディングカテーテル
WO2015103617A1 (en) 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
EP4059563B1 (en) 2014-01-27 2023-09-27 Medtronic Ireland Manufacturing Unlimited Company Neuromodulation catheters having jacketed neuromodulation elements and related devices
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
EP3102136B1 (en) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US10492842B2 (en) 2014-03-07 2019-12-03 Medtronic Ardian Luxembourg S.A.R.L. Monitoring and controlling internally administered cryotherapy
US10463424B2 (en) 2014-03-11 2019-11-05 Medtronic Ardian Luxembourg S.A.R.L. Catheters with independent radial-expansion members and associated devices, systems, and methods
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
JP2017513600A (ja) 2014-04-24 2017-06-01 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 編組シャフトを有する神経調節カテーテル及び関連システム及び方法
US10610292B2 (en) 2014-04-25 2020-04-07 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems, and methods for monitoring and/or controlling deployment of a neuromodulation element within a body lumen and related technology
US10478249B2 (en) 2014-05-07 2019-11-19 Pythagoras Medical Ltd. Controlled tissue ablation techniques
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
EP3145425A4 (en) 2014-05-22 2018-02-14 Aegea Medical, Inc. Systems and methods for performing endometrial ablation
US10179019B2 (en) 2014-05-22 2019-01-15 Aegea Medical Inc. Integrity testing method and apparatus for delivering vapor to the uterus
US11154712B2 (en) 2014-08-28 2021-10-26 Medtronic Ardian Luxembourg S.A.R.L. Methods for assessing efficacy of renal neuromodulation and associated systems and devices
US20160058503A1 (en) * 2014-08-28 2016-03-03 Medtronic Ardian Luxembourg S.a.r.I. Methods for modulating renal nerve tissue and associated systems and devices
EP3791817A1 (en) 2014-10-01 2021-03-17 Medtronic Ardian Luxembourg S.à.r.l. Systems for evaluating neuromodulation therapy via hemodynamic responses
WO2016075536A2 (en) 2014-11-14 2016-05-19 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems and methods
JP6673598B2 (ja) 2014-11-19 2020-03-25 エピックス セラピューティクス，インコーポレイテッド ペーシングを伴う組織の高分解能マッピング
SG11201703943VA (en) 2014-11-19 2017-06-29 Advanced Cardiac Therapeutics Inc Ablation devices, systems and methods of using a high-resolution electrode assembly
US10667736B2 (en) 2014-12-17 2020-06-02 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing sympathetic nervous system tone for neuromodulation therapy
JP6723249B2 (ja) 2015-01-30 2020-07-15 アールエフイーエムビー ホールディングス リミテッド ライアビリティ カンパニー 軟部組織を切除するためのシステムおよび方法
WO2016127162A1 (en) * 2015-02-06 2016-08-11 Rfemb Holdings, Llc Radio-frequency electrical membrane breakdown for the treatment of cardiac rhythm disorders and for renal neuromodulation
EP3274037B1 (en) 2015-03-27 2021-11-03 Kalila Medical, Inc. Steerable medical devices
JP6820864B2 (ja) 2015-04-24 2021-01-27 カリラ メディカル インコーポレイテッド 操向可能な医療器具、システムおよび使用方法
US10383685B2 (en) 2015-05-07 2019-08-20 Pythagoras Medical Ltd. Techniques for use with nerve tissue
JP6866367B2 (ja) 2015-11-09 2021-04-28 カリラ メディカル インコーポレイテッド 医療器具の操向アセンブリおよび使用方法
WO2017087549A1 (en) 2015-11-16 2017-05-26 Apama Medical, Inc. Energy delivery devices
CN109069624A (zh) 2016-01-15 2018-12-21 瑞美控股有限责任公司 癌症的免疫治疗
EP3416551B1 (en) 2016-02-19 2022-10-12 Aegea Medical Inc. Apparatus for determining the integrity of a bodily cavity
CA3017269A1 (en) 2016-03-15 2017-09-21 Epix Therapeutics, Inc. Improved devices, systems and methods for irrigated ablation
US10736692B2 (en) 2016-04-28 2020-08-11 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of cancer
US11678932B2 (en) 2016-05-18 2023-06-20 Symap Medical (Suzhou) Limited Electrode catheter with incremental advancement
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
JP7287888B2 (ja) 2016-06-27 2023-06-06 ギャラリー，インコーポレイテッド ジェネレータ、電極付きのカテーテル、及び肺通路の治療方法
US10231784B2 (en) 2016-10-28 2019-03-19 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics
WO2018089795A1 (en) 2016-11-10 2018-05-17 Qoravita LLC System and method for applying a low frequency magnetic field to biological tissues
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US10646713B2 (en) 2017-02-22 2020-05-12 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for treating patients via renal neuromodulation to reduce a risk of developing cognitive impairment
CN110809448B (zh) 2017-04-27 2022-11-25 Epix疗法公司 确定导管尖端与组织之间接触的性质
EP3459480A1 (en) 2017-09-21 2019-03-27 National University of Ireland, Galway Apparatus for localising an electrical field
US10849685B2 (en) 2018-07-18 2020-12-01 Ablative Solutions, Inc. Peri-vascular tissue access catheter with locking handle
SG11202103476SA (en) 2018-10-06 2021-05-28 Symap Medical Suzhou Limited System and method for mapping functional nerves innervating wall of arteries, 3-d mapping and catheters for same
CA3150339A1 (en) 2019-09-12 2021-03-18 Brian W. Donovan TISSUE MODULATION SYSTEMS AND METHODS
EP4057925B1 (en) 2020-02-28 2023-10-11 St. Jude Medical, Cardiology Division, Inc. Electrode assembly including expandable isolation member

Family Cites Families (1392)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US553611A (en) * 1896-01-28 James constable gilroy
US1006610A (en) 1906-08-22 1911-10-24 Earl G Watrous Lavatory-fixture.
US1004660A (en) 1907-04-08 1911-10-03 Robert Klotz Advertising device.
US1026407A (en) 1908-12-21 1912-05-14 Steel Shoe Company Footwear.
US1006031A (en) 1910-03-07 1911-10-17 Frank H Weatherly Pipe-joint.
US1017857A (en) 1910-03-25 1912-02-20 Amphion Piano Player Company Valve for pneumatic actions.
US1003498A (en) 1910-10-25 1911-09-19 William Washington Pittman Harrow.
US1017850A (en) 1911-03-25 1912-02-20 John Franklin Cesario Rotary motor.
US2130758A (en) * 1935-06-01 1938-09-20 E J Rose Mfg Company Of Califo Electrode for diathermy treatment and the like
US2276995A (en) * 1938-01-22 1942-03-17 A J Ginsberg Electrotherapy
US2276996A (en) * 1940-11-30 1942-03-17 A J Ginsberg Non-radio-interfering therapeutic apparatus
US3181535A (en) 1957-10-04 1965-05-04 Diapulse Mfg Corp Of America Athermapeutic apparatus
US3043310A (en) 1959-04-24 1962-07-10 Diapulse Mfg Corp Of America Treatment head for athermapeutic apparatus
US3127895A (en) 1962-07-02 1964-04-07 Dynapower System Corp Therapeutic pulse generation and control circuit
US3270746A (en) 1963-08-26 1966-09-06 Dynapower Systems Corp High-performance electrotherapeutic treatment head
US3329149A (en) 1964-10-28 1967-07-04 Dynapower Systems Corp Of Cali Supporting arm for electrotherapeutic treatment head
US3563246A (en) 1967-04-24 1971-02-16 Intelectron Corp Method and apparatus for improving neural performance in human subjects by electrotherapy
US3522811A (en) 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
SE346468B (zh) 1969-02-24 1972-07-10 Lkb Medical Ab
JPS499882Y1 (zh) 1969-09-11 1974-03-08
US3670737A (en) 1970-07-02 1972-06-20 Diapulse Corp Of America Ultra-short wave athermapeutic apparatus
US3760812A (en) 1971-03-19 1973-09-25 Univ Minnesota Implantable spiral wound stimulation electrodes
US3774620A (en) 1971-06-14 1973-11-27 Nemectron Gmbh Electromedicinal apparatus for interference current therapy
US3895639A (en) 1971-09-07 1975-07-22 Rodler Ing Hans Apparatus for producing an interference signal at a selected location
US3800802A (en) 1972-01-07 1974-04-02 Int Medical Electronics Ltd Short-wave therapy apparatus
US3752162A (en) 1972-04-10 1973-08-14 Dow Corning Artificial cutaneous stoma
US3794022A (en) 1972-06-30 1974-02-26 E Nawracaj Dual oscillator, variable pulse duration electrotherapeutic device
US3803463A (en) 1972-07-10 1974-04-09 J Cover Weapon for immobilization and capture
US3897789A (en) 1973-09-13 1975-08-05 Stanley J Blanchard Acupuncture apparatus
US3894532A (en) 1974-01-17 1975-07-15 Acupulse Inc Instruments for transcutaneous and subcutaneous investigation and treatment
US3911930A (en) 1974-03-01 1975-10-14 Stimulation Tech Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation
US4011861A (en) 1974-04-03 1977-03-15 Case Western Reserve University Implantable electric terminal for organic tissue
US4055190A (en) 1974-12-19 1977-10-25 Michio Tany Electrical therapeutic apparatus
US3952751A (en) 1975-01-08 1976-04-27 W. Denis Kendall High-performance electrotherapeutic apparatus
US4026300A (en) 1975-03-14 1977-05-31 Liberty Mutual Method and apparatus for interfacing to nerves
US3987790A (en) 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4266532A (en) 1976-11-17 1981-05-12 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4315503A (en) 1976-11-17 1982-02-16 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4105017A (en) 1976-11-17 1978-08-08 Electro-Biology, Inc. Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment
US4071033A (en) 1976-12-20 1978-01-31 Nawracaj Edward P Electrotherapeutic device with modulated dual signals
US4141365A (en) 1977-02-24 1979-02-27 The Johns Hopkins University Epidural lead electrode and insertion needle
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4305115A (en) 1979-03-14 1981-12-08 Harry H. Leveen Electrostatic shield
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4341221A (en) 1980-10-07 1982-07-27 Medtronic, Inc. Shielded recording electrode system
US4405305A (en) 1980-10-27 1983-09-20 University Of Utah Research Foundation Subcutaneous peritoneal injection catheter
US4379462A (en) 1980-10-29 1983-04-12 Neuromed, Inc. Multi-electrode catheter assembly for spinal cord stimulation
CS226514B1 (en) 1981-01-28 1984-04-16 Petr Ing Csc Slovak Apparatus for stimulating live tissues
US4454883A (en) 1982-02-16 1984-06-19 Therafield Holdings Limited Electrotherapeutic apparatus
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4467808A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
DE3300668A1 (de) 1983-01-11 1984-07-12 Siemens AG, 1000 Berlin und 8000 München Elektrode fuer medizinische anwendungen
FR2541902B1 (fr) 1983-03-04 1986-02-07 Cofrem International Sa Appareil therapeutique athermique
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
WO1985001213A1 (en) 1983-09-14 1985-03-28 Jacob Zabara Neurocybernetic prosthesis
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4816016A (en) 1984-03-16 1989-03-28 Pudenz-Schulte Medical Research Corp. Subcutaneous infusion reservoir and pump system
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US4674482A (en) 1984-09-12 1987-06-23 Irt, Inc. Pulse electro-magnetic field therapy device with auto bias circuit
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4608985A (en) 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
US4824436A (en) 1985-04-09 1989-04-25 Harvey Wolinsky Method for the prevention of restenosis
US5449343A (en) 1985-07-30 1995-09-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
FR2592791A1 (fr) 1986-01-14 1987-07-17 Ire Celltarg Sa Composition pharmaceutique, contenant un anesthesique local et/ou un analgesique central encapsule dans des liposomes
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
JPS62181225U (zh) 1986-05-07 1987-11-17
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US5014699A (en) 1986-05-23 1991-05-14 Trustees Of The University Of Pennsylvania Electromagnetic method and apparatus for healing living tissue
US4998532A (en) 1986-05-23 1991-03-12 Lti Biomedical, Inc. Portable electro-therapy system
US4715852A (en) 1986-07-21 1987-12-29 Eaton Corporation Implanted medication infusion device
US4774967A (en) 1986-09-09 1988-10-04 American Biointerface Corporation Method and apparatus for mammalian nerve regeneration
US4791931A (en) 1987-08-13 1988-12-20 Pacesetter Infusion, Ltd. Demand pacemaker using an artificial baroreceptor reflex
US4852573A (en) 1987-12-04 1989-08-01 Kennedy Philip R Implantable neural electrode
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
EP0398960B1 (en) 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US4887605A (en) 1988-02-18 1989-12-19 Angelsen Bjorn A J Laser catheter delivery system for controlled atheroma ablation combining laser angioplasty and intra-arterial ultrasonic imagining
US4890623A (en) 1988-03-14 1990-01-02 C. R. Bard, Inc. Biopotential sensing device and method for making
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
CA1319174C (en) 1988-04-21 1993-06-15 Lawrence E. Bertolucci Electrical nerve stimulation device for nausea control
US5906936A (en) * 1988-05-04 1999-05-25 Yeda Research And Development Co. Ltd. Endowing lymphocytes with antibody specificity
GB8814898D0 (en) 1988-06-22 1988-07-27 Evans J M Catheters & methods of manufacture
DE68922497T2 (de) 1988-08-24 1995-09-14 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US4966597A (en) 1988-11-04 1990-10-30 Cosman Eric R Thermometric cardiac tissue ablation electrode with ultra-sensitive temperature detection
US5094242A (en) 1988-11-07 1992-03-10 Regents Of The University Of California Implantable nerve stimulation device
US5059423A (en) 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5057318A (en) 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
AU4945490A (en) 1989-01-06 1990-08-01 Angioplasty Systems Inc. Electrosurgical catheter for resolving atherosclerotic plaque
US5458631A (en) 1989-01-06 1995-10-17 Xavier; Ravi Implantable catheter with electrical pulse nerve stimulators and drug delivery system
US5037391A (en) 1989-01-09 1991-08-06 Pilot Cardiovascular Systems, Inc. Steerable angioplasty device
US5203772A (en) 1989-01-09 1993-04-20 Pilot Cardiovascular Systems, Inc. Steerable medical device
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US5087244A (en) 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5078717A (en) 1989-04-13 1992-01-07 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5006119A (en) 1989-05-25 1991-04-09 Engineering & Research Associates, Inc. Hollow core coaxial catheter
JPH0314967A (ja) 1989-06-08 1991-01-23 Kubota Corp 農作業機の走行変速構造
JPH0341967A (ja) 1989-07-11 1991-02-22 Olympus Optical Co Ltd 薬剤徐放装置
US20030220521A1 (en) 1989-07-27 2003-11-27 G.D. Searle & Co. Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension
US5662701A (en) 1989-08-18 1997-09-02 Endovascular Instruments, Inc. Anti-stenotic method and product for occluded and partially occluded arteries
CA2067110C (en) 1989-09-08 2001-07-31 John E. Abele Physiologic low stress angioplasty
US5112614A (en) 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5231386A (en) 1990-07-24 1993-07-27 Home Row, Inc. Keyswitch-integrated pointing assembly
US5109859A (en) 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
RU1785710C (en) 1989-10-06 1993-01-07 Vremennyj Nauchnyj Kollektiv O Microwave resonant therapeutic device
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5344395A (en) 1989-11-13 1994-09-06 Scimed Life Systems, Inc. Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
US5851206A (en) 1990-03-13 1998-12-22 The Regents Of The University Of California Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment
US5084006A (en) 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5193048A (en) 1990-04-27 1993-03-09 Kaufman Dennis R Stun gun with low battery indicator and shutoff timer
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5184617A (en) 1990-06-05 1993-02-09 Staodyn, Inc. Output pulse compensation for therapeutic-type electronic devices
US5095905A (en) 1990-06-07 1992-03-17 Medtronic, Inc. Implantable neural electrode
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
EP0533816B1 (en) 1990-06-15 1995-06-14 Cortrak Medical, Inc. Drug delivery apparatus
US5498238A (en) 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5058584A (en) 1990-08-30 1991-10-22 Medtronic, Inc. Method and apparatus for epidural burst stimulation for angina pectoris
US5170803A (en) 1990-09-28 1992-12-15 Brunswick Biomedical Technologies, Inc. Esophageal displacement electrode
US5111815A (en) 1990-10-15 1992-05-12 Cardiac Pacemakers, Inc. Method and apparatus for cardioverter/pacer utilizing neurosensing
JP3041967B2 (ja) 1990-12-13 2000-05-15 ソニー株式会社 ディジタル信号符号化装置
US5139496A (en) 1990-12-20 1992-08-18 Hed Aharon Z Ultrasonic freeze ablation catheters and probes
EP0491979A1 (de) 1990-12-22 1992-07-01 Peter Dr. Ing. Osypka Herzschrittmacher-Katheter mit zwei Polen
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5405318A (en) 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5997497A (en) 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5380274A (en) 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5312328A (en) 1991-01-11 1994-05-17 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5447509A (en) 1991-01-11 1995-09-05 Baxter International Inc. Ultrasound catheter system having modulated output with feedback control
US5916192A (en) 1991-01-11 1999-06-29 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty-atherectomy catheter and method of use
US5267954A (en) 1991-01-11 1993-12-07 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5957882A (en) 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5368558A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5304115A (en) 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5368557A (en) 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having multiple ultrasound transmission members
US5542917A (en) 1991-01-11 1996-08-06 Baxter International, Inc. Ultrasound delivery catheters incorporating improved distal tip construction
ES2098333T3 (es) 1991-01-31 1997-05-01 Baxter Int Bomba de instilacion automatica con cartuchos de memoria sustituibles.
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5329923A (en) 1991-02-15 1994-07-19 Lundquist Ingemar H Torquable catheter
AU660444B2 (en) 1991-02-15 1995-06-29 Ingemar H. Lundquist Torquable catheter and method
US5465717A (en) 1991-02-15 1995-11-14 Cardiac Pathways Corporation Apparatus and Method for ventricular mapping and ablation
US5425364A (en) 1991-02-15 1995-06-20 Cardiac Pathways Corporation Flexible strip assembly without feedthrough holes and device utilizing the same
US5345936A (en) 1991-02-15 1994-09-13 Cardiac Pathways Corporation Apparatus with basket assembly for endocardial mapping
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5199428A (en) 1991-03-22 1993-04-06 Medtronic, Inc. Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
US6309379B1 (en) 1991-05-23 2001-10-30 Lloyd K. Willard Sheath for selective delivery of multiple intravascular devices and methods of use thereof
US5458568A (en) 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
WO1992020291A1 (en) 1991-05-24 1992-11-26 Applied Medical Resources, Inc. Articulating tissue cutter assembly
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5213098A (en) 1991-07-26 1993-05-25 Medtronic, Inc. Post-extrasystolic potentiation stimulation with physiologic sensor feedback
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
WO1993006780A1 (en) 1991-10-03 1993-04-15 The General Hospital Corporation Apparatus and method for vasodilation
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
WO1993008750A2 (en) 1991-11-04 1993-05-13 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
DE69233091T2 (de) 1991-11-08 2004-05-06 Boston Scientific Ltd., St. Michael Ablationselektrode mit isoliertem temperaturmesselement
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5203326A (en) 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
DE69214672T2 (de) 1991-12-20 1997-04-03 Technomed Medical Systems Schallwellen aussendende,thermische effekte und kavitationseffekte erzeugende vorrichtung fur die ultraschalltherapie
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US5419767A (en) 1992-01-07 1995-05-30 Thapliyal And Eggers Partners Methods and apparatus for advancing catheters through severely occluded body lumens
US5354297A (en) 1992-02-14 1994-10-11 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5327905A (en) 1992-02-14 1994-07-12 Boaz Avitall Biplanar deflectable catheter for arrhythmogenic tissue ablation
US5993389A (en) 1995-05-22 1999-11-30 Ths International, Inc. Devices for providing acoustic hemostasis
WO1993018415A1 (en) 1992-03-09 1993-09-16 University Of Washington Image neurography and diffusion anisotropy imaging
US5306250A (en) 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
US5318525A (en) 1992-04-10 1994-06-07 Medtronic Cardiorhythm Steerable electrode catheter
US5300068A (en) * 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5443470A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5562720A (en) 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5295484A (en) 1992-05-19 1994-03-22 Arizona Board Of Regents For And On Behalf Of The University Of Arizona Apparatus and method for intra-cardiac ablation of arrhythmias
US5370680A (en) 1992-05-27 1994-12-06 Magnetic Resonance Therapeutics, Inc. Athermapeutic apparatus employing electro-magnetic fields
WO1994000188A1 (en) 1992-06-24 1994-01-06 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5772590A (en) 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US5782239A (en) 1992-06-30 1998-07-21 Cordis Webster, Inc. Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5399164A (en) 1992-11-02 1995-03-21 Catheter Imaging Systems Catheter having a multiple durometer
US5382228A (en) 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
US5538504A (en) 1992-07-14 1996-07-23 Scimed Life Systems, Inc. Intra-extravascular drug delivery catheter and method
US5484400A (en) 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US5542916A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Dual-channel RF power delivery system
US5437288A (en) 1992-09-04 1995-08-01 Mayo Foundation For Medical Education And Research Flexible catheter guidewire
DE4229693A1 (de) 1992-09-05 1994-03-10 Achim Dr Hansjuergens Elektrotherapeutisches Gerät
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
JP3007687B2 (ja) 1992-09-10 2000-02-07 チルドレンズ メディカル センター コーポレイション 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5478303A (en) 1992-09-18 1995-12-26 Foley-Nolan; Darragh Electromagnetic apparatus for use in therapy
US5338662A (en) 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5553611A (en) 1994-01-06 1996-09-10 Endocardial Solutions, Inc. Endocardial measurement method
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
CA2107741C (en) 1992-10-07 2000-06-27 Peter T. Keith Ablation devices and methods of use
US5634901A (en) 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5334193A (en) 1992-11-13 1994-08-02 American Cardiac Ablation Co., Inc. Fluid cooled ablation catheter
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
CA2109980A1 (en) 1992-12-01 1994-06-02 Mir A. Imran Steerable catheter with adjustable bend location and/or radius and method
US5256141A (en) 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus
US5317155A (en) 1992-12-29 1994-05-31 The Electrogesic Corporation Corona discharge apparatus
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
ATE178218T1 (de) 1993-02-05 1999-04-15 Joe W And Dorothy Dorsett Brow Ultraschallballonkatheter für angioplastik
US6620188B1 (en) 1998-08-24 2003-09-16 Radiant Medical, Inc. Methods and apparatus for regional and whole body temperature modification
US5569274A (en) 1993-02-22 1996-10-29 Heartport, Inc. Endoscopic vascular clamping system and method
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5792187A (en) 1993-02-22 1998-08-11 Angeion Corporation Neuro-stimulation to control pain during cardioversion defibrillation
EP0673225A4 (en) 1993-03-16 1996-01-24 Ep Technologies ARRANGEMENT FOR MULTI-DIMENSIONAL DISPLAY AND TISSUE ABLATION OF THE HEART.
US5636634A (en) 1993-03-16 1997-06-10 Ep Technologies, Inc. Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes
US5476495A (en) 1993-03-16 1995-12-19 Ep Technologies, Inc. Cardiac mapping and ablation systems
US5397338A (en) 1993-03-29 1995-03-14 Maven Labs, Inc. Electrotherapy device
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
DK0702723T3 (da) 1993-04-21 2003-01-13 Pasteur Institut Biokompatibelt implantat til ekspression og udskillelse af terapeutisk forbindelse in vivo
FR2704151B1 (fr) 1993-04-21 1995-07-13 Klotz Antoine Olivier Dispositif électronique destiné à la stimulation adrénergique du système sympathique relatif à la média veineuse.
US6517811B2 (en) 1993-05-06 2003-02-11 Research Corporation Technologies, Inc. Compounds for cancer imaging and therapy
US5611777A (en) 1993-05-14 1997-03-18 C.R. Bard, Inc. Steerable electrode catheter
US5590654A (en) 1993-06-07 1997-01-07 Prince; Martin R. Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent
US5584863A (en) 1993-06-24 1996-12-17 Electropharmacology, Inc. Pulsed radio frequency electrotherapeutic system
DE69432148T2 (de) 1993-07-01 2003-10-16 Boston Scient Ltd Katheter zur bilddarstellung, zur anzeige elektrischer signale und zur ablation
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
US5545200A (en) 1993-07-20 1996-08-13 Medtronic Cardiorhythm Steerable electrophysiology catheter
US5487757A (en) 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5458585A (en) 1993-07-28 1995-10-17 Cardiovascular Imaging Systems, Inc. Tracking tip for a work element in a catheter system
US5415633A (en) 1993-07-28 1995-05-16 Active Control Experts, Inc. Remotely steered catheterization device
US5431649A (en) 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5507791A (en) 1993-08-31 1996-04-16 Sit'ko; Sergei P. Microwave resonance therapy
US5607462A (en) 1993-09-24 1997-03-04 Cardiac Pathways Corporation Catheter assembly, catheter and multi-catheter introducer for use therewith
US5843124A (en) 1993-09-28 1998-12-01 Hemodynamics, Inc. Surface opening adhesive sealer
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5417672A (en) 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5582609A (en) 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
WO1995010319A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Electrodes for creating lesions in body tissue
US5400784A (en) 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
US5397308A (en) 1993-10-22 1995-03-14 Scimed Life Systems, Inc. Balloon inflation measurement apparatus
US5470352A (en) 1993-10-29 1995-11-28 Northeastern University Balloon angioplasty device
US5433739A (en) 1993-11-02 1995-07-18 Sluijter; Menno E. Method and apparatus for heating an intervertebral disc for relief of back pain
US5571147A (en) * 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
JPH07157424A (ja) 1993-12-03 1995-06-20 Lintec Corp 局所麻酔用ゲル製剤
US5730127A (en) 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
CA2138076A1 (en) 1993-12-17 1995-06-18 Philip E. Eggers Monopolar electrosurgical instruments
US5471988A (en) 1993-12-24 1995-12-05 Olympus Optical Co., Ltd. Ultrasonic diagnosis and therapy system in which focusing point of therapeutic ultrasonic wave is locked at predetermined position within observation ultrasonic scanning range
US5458626A (en) 1993-12-27 1995-10-17 Krause; Horst E. Method of electrical nerve stimulation for acceleration of tissue healing
US6099524A (en) 1994-01-28 2000-08-08 Cardiac Pacemakers, Inc. Electrophysiological mapping and ablation catheter and method
US5697975A (en) 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
US6858024B1 (en) 1994-02-14 2005-02-22 Scimed Life Systems, Inc. Guide catheter having selected flexural modulus segments
DE4408108A1 (de) 1994-03-10 1995-09-14 Bavaria Med Tech Katheter zur Injektion eines Fluid bzw. eines Arneimittelns
US5588962A (en) 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
US5464395A (en) 1994-04-05 1995-11-07 Faxon; David P. Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway
GB9407135D0 (en) 1994-04-11 1994-06-01 Aberdeen University And Plasma Treatment of osteoporosis
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5882333A (en) 1994-05-13 1999-03-16 Cardima, Inc. Catheter with deflectable distal section
WO1995033514A1 (en) 1994-06-09 1995-12-14 Magnetic Resonance Therapeutics, Inc. Electro-therapeutic method
US5505700A (en) 1994-06-14 1996-04-09 Cordis Corporation Electro-osmotic infusion catheter
US5421349A (en) 1994-06-16 1995-06-06 Cordis Corporation Atraumatic proximal guidewire end
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
JP3578460B2 (ja) 1994-06-27 2004-10-20 ボストン サイエンティフィック リミテッド 体内の温度を感知するためのシステム及び方法
US5857998A (en) 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5514092A (en) 1994-08-08 1996-05-07 Schneider (Usa) Inc. Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5454782A (en) 1994-08-11 1995-10-03 Perkins; Rodney C. Translumenal circumferential energy delivery device
EP0776235A4 (en) 1994-08-17 1999-08-25 Magnetic Resonance Therapeutic ELECTROTHERAPEUTIC SYSTEM
US8025661B2 (en) 1994-09-09 2011-09-27 Cardiofocus, Inc. Coaxial catheter instruments for ablation with radiant energy
DE4433111A1 (de) 1994-09-16 1996-03-21 Fraunhofer Ges Forschung Cuff-Elektrode
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5540734A (en) 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
US5876336A (en) 1994-10-11 1999-03-02 Ep Technologies, Inc. Systems and methods for guiding movable electrode elements within multiple-electrode structure
WO1996011723A1 (en) 1994-10-17 1996-04-25 Australasian Medical Technology Limited Devices and methods for implementation of pulsed electromagnetic field therapy
US5722401A (en) 1994-10-19 1998-03-03 Cardiac Pathways Corporation Endocardial mapping and/or ablation catheter probe
US5810742A (en) 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5817144A (en) 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US5660848A (en) 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
DE69529572T2 (de) 1994-11-10 2003-06-18 Univ Kentucky Res Foundation L Implantierbare wiederauffüllbare vorrichtung mit gesteuerter freisetzung zur verabreichung von arzneistoffen unmittelbar an einen inneren teil des körpers
US5588960A (en) 1994-12-01 1996-12-31 Vidamed, Inc. Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5569198A (en) 1995-01-23 1996-10-29 Cortrak Medical Inc. Microporous catheter
FR2729845B1 (fr) 1995-02-01 1997-07-25 Centre Nat Rech Scient Catheter d'imagerie echographique endocavitaire
US5797849A (en) 1995-03-28 1998-08-25 Sonometrics Corporation Method for carrying out a medical procedure using a three-dimensional tracking and imaging system
US5916178A (en) 1995-03-30 1999-06-29 Medtronic, Inc. Steerable high support guidewire with thin wall nitinol tube
WO1996034646A1 (en) 1995-05-01 1996-11-07 Medtronic Cardiorhythm Dual curve ablation catheter and method
WO1996034571A1 (en) 1995-05-04 1996-11-07 Cosman Eric R Cool-tip electrode thermosurgery system
US6251104B1 (en) 1995-05-10 2001-06-26 Eclipse Surgical Technologies, Inc. Guiding catheter system for ablating heart tissue
US5984907A (en) 1995-06-05 1999-11-16 Ep Technologies, Inc. Transition sleeve assembly for catheters
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6149620A (en) * 1995-11-22 2000-11-21 Arthrocare Corporation System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid
JPH10503964A (ja) 1995-06-07 1998-04-14 ゴア ハイブリッド テクノロジーズ，インコーポレイティド 治療用デバイスのための移植可能な閉じ込め装置並びにその中にそのデバイスを装填及び再装填する方法
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
CA2195119C (en) 1995-06-09 2001-09-11 Mark Chasin Formulations and methods for providing prolonged local anesthesia
US6322558B1 (en) 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
US8241217B2 (en) 1995-06-29 2012-08-14 Teratech Corporation Portable ultrasound imaging data
EP0835075A4 (en) 1995-06-30 1999-06-23 Boston Scient Corp CATHETER FOR ULTRASONIC IMAGING, WITH A CUTTING ELEMENT
US5865801A (en) 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5711326A (en) 1995-08-25 1998-01-27 Whirlpool Corporation Dishwasher accumulator soil removal grating for a filter system
US5860922A (en) 1995-09-07 1999-01-19 Technion Research And Development Foundation Ltd. Determining blood flow by measurement of temperature
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US6615071B1 (en) 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
AU709432B2 (en) 1995-09-20 1999-08-26 California Institute Of Technology Detecting thermal discrepancies in vessel walls
US6763261B2 (en) 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
US6726677B1 (en) 1995-10-13 2004-04-27 Transvascular, Inc. Stabilized tissue penetrating catheters
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
IL151563A0 (en) 1995-10-13 2003-04-10 Transvascular Inc A longitudinal compression apparatus for compressing tissue
US6283960B1 (en) 1995-10-24 2001-09-04 Oratec Interventions, Inc. Apparatus for delivery of energy to a surgical site
US5755750A (en) 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
US6073048A (en) 1995-11-17 2000-06-06 Medtronic, Inc. Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure
US5823955A (en) 1995-11-20 1998-10-20 Medtronic Cardiorhythm Atrioventricular valve tissue ablation catheter and method
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
CN2291164Y (zh) 1996-12-23 1998-09-16 祝强 降压仪
US5830213A (en) 1996-04-12 1998-11-03 Ep Technologies, Inc. Systems for heating and ablating tissue using multifunctional electrode structures
RU2189221C2 (ru) 1996-02-02 2002-09-20 Элзэ Копэрейшн Устройство для введения активного вещества (варианты), способ его изготовления и способ лечения пациента, страдающего раком предстательной железы
ATE247429T1 (de) 1996-02-02 2003-09-15 Transvascular Inc System für interstitielle transvaskuläre chirurgische eingriffe
US5807249A (en) 1996-02-16 1998-09-15 Medtronic, Inc. Reduced stiffness, bidirectionally deflecting catheter assembly
US5913876A (en) 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US5843016A (en) 1996-03-18 1998-12-01 Physion S.R.L. Electromotive drug administration for treatment of acute urinary outflow obstruction
JP3529537B2 (ja) 1996-03-25 2004-05-24 テルモ株式会社 電極カテーテル
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US6022309A (en) 1996-04-24 2000-02-08 The Regents Of The University Of California Opto-acoustic thrombolysis
US6898454B2 (en) 1996-04-25 2005-05-24 The Johns Hopkins University Systems and methods for evaluating the urethra and the periurethral tissues
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6449507B1 (en) * 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US6735471B2 (en) * 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
US5713923A (en) 1996-05-13 1998-02-03 Medtronic, Inc. Techniques for treating epilepsy by brain stimulation and drug infusion
US5938690A (en) 1996-06-07 1999-08-17 Advanced Neuromodulation Systems, Inc. Pain management system and method
US5824026A (en) 1996-06-12 1998-10-20 The Spectranetics Corporation Catheter for delivery of electric energy and a process for manufacturing same
US5861021A (en) 1996-06-17 1999-01-19 Urologix Inc Microwave thermal therapy of cardiac tissue
US20020040204A1 (en) * 1996-06-24 2002-04-04 Dev Nagendu B. Electroporation-enhanced inhibition of vascular neointimal hyperplasia
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5983141A (en) 1996-06-27 1999-11-09 Radionics, Inc. Method and apparatus for altering neural tissue function
US5924997A (en) 1996-07-29 1999-07-20 Campbell; Thomas Henderson Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US6058328A (en) 1996-08-06 2000-05-02 Pacesetter, Inc. Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof
US7603166B2 (en) 1996-09-20 2009-10-13 Board Of Regents University Of Texas System Method and apparatus for detection of vulnerable atherosclerotic plaque
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US6451044B1 (en) 1996-09-20 2002-09-17 Board Of Regents, The University Of Texas System Method and apparatus for heating inflammed tissue
US5954740A (en) 1996-09-23 1999-09-21 Boston Scientific Corporation Catheter balloon having raised radial segments
US5957941A (en) 1996-09-27 1999-09-28 Boston Scientific Corporation Catheter system and drive assembly thereof
US5800464A (en) 1996-10-03 1998-09-01 Medtronic, Inc. System for providing hyperpolarization of cardiac to enhance cardiac function
US5814079A (en) 1996-10-04 1998-09-29 Medtronic, Inc. Cardiac arrhythmia management by application of adnodal stimulation for hyperpolarization of myocardial cells
US5704908A (en) 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US5848969A (en) 1996-10-28 1998-12-15 Ep Technologies, Inc. Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5893885A (en) 1996-11-01 1999-04-13 Cordis Webster, Inc. Multi-electrode ablation catheter
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US6081749A (en) 1997-08-13 2000-06-27 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US5954719A (en) 1996-12-11 1999-09-21 Irvine Biomedical, Inc. System for operating a RF ablation generator
CA2225521C (en) 1996-12-27 2004-04-06 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery apparatus
US5871449A (en) 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
ES2208963T3 (es) 1997-01-03 2004-06-16 Biosense, Inc. Endoprotesis vascular sensible a la presion.
US6026326A (en) 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
EP0948373B1 (en) 1997-01-13 2004-09-01 Neurodan A/S An implantable nerve stimulator electrode
EP1006908A2 (en) 1997-02-12 2000-06-14 Oratec Interventions, Inc. Concave probe for arthroscopic surgery
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
AU6667698A (en) 1997-02-26 1998-09-18 Alfred E. Mann Foundation For Scientific Research Battery-powered patient implantable device
US5899898A (en) 1997-02-27 1999-05-04 Cryocath Technologies Inc. Cryosurgical linear ablation
US6416510B1 (en) 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6032675A (en) 1997-03-17 2000-03-07 Rubinsky; Boris Freezing method for controlled removal of fatty tissue by liposuction
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
AU6942198A (en) 1997-03-27 1998-10-22 Advanced Bionics, Inc. System of implantable devices for monitoring and/or affecting body para meters
JP3041967U (ja) 1997-03-28 1997-10-03 明男 中村 炎検知システム
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US6634363B1 (en) 1997-04-07 2003-10-21 Broncus Technologies, Inc. Methods of treating lungs having reversible obstructive pulmonary disease
US7027869B2 (en) 1998-01-07 2006-04-11 Asthmatx, Inc. Method for treating an asthma attack
US5827203A (en) 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
US6117128A (en) 1997-04-30 2000-09-12 Kenton W. Gregory Energy delivery catheter and method for the use thereof
US5948007A (en) 1997-04-30 1999-09-07 Medtronic, Inc. Dual channel implantation neurostimulation techniques
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US5971983A (en) 1997-05-09 1999-10-26 The Regents Of The University Of California Tissue ablation device and method of use
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US5989208A (en) 1997-05-16 1999-11-23 Nita; Henry Therapeutic ultrasound system
US6326020B1 (en) 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
US5827278A (en) 1997-05-20 1998-10-27 Cordis Webster, Inc. Deflectable tip electrode catheter with nylon stiffener and compression coil
CN1230120C (zh) 1997-05-23 2005-12-07 普罗里森姆股份有限公司 由mri引导的治疗装置
US20030109778A1 (en) 1997-06-20 2003-06-12 Cardiac Assist Devices, Inc. Electrophysiology/ablation catheter and remote actuator therefor
JP2002516586A (ja) 1997-06-23 2002-06-04 ティーエイチエス インターナショナル，インコーポレイテッド 音響止血を提供する方法及びその装置
US6161048A (en) 1997-06-26 2000-12-12 Radionics, Inc. Method and system for neural tissue modification
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
US6251109B1 (en) 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
BR9815499A (pt) 1997-07-02 2001-01-02 Euro Celtique Sa Anestesia prolongada nas juntas e nos espacos corporais.
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
JP4000243B2 (ja) 1997-07-08 2007-10-31 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 周辺部切除装置組立体および方法
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6997925B2 (en) 1997-07-08 2006-02-14 Atrionx, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
ATE353689T1 (de) 1997-07-16 2007-03-15 Metacure Nv Einrichtung zur steuerung eines glatten muskels
US6080151A (en) 1997-07-21 2000-06-27 Daig Corporation Ablation catheter
US9023031B2 (en) 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
JP2001514921A (ja) 1997-08-13 2001-09-18 サークス， インコーポレイテッド 組織収縮のための非侵襲性デバイス、方法、およびシステム
AU8764998A (en) 1997-09-04 1999-03-22 Alcon Laboratories, Inc. Flexible tube with circular grooves of varying width and depth
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US6200312B1 (en) 1997-09-11 2001-03-13 Vnus Medical Technologies, Inc. Expandable vein ligator catheter having multiple electrode leads
US6401719B1 (en) 1997-09-11 2002-06-11 Vnus Medical Technologies, Inc. Method of ligating hollow anatomical structures
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6007514A (en) 1997-09-30 1999-12-28 Nita; Henry Ultrasound system with pathfinding guidewire
US6231516B1 (en) 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
US6048338A (en) 1997-10-15 2000-04-11 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US6917834B2 (en) 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
US6093197A (en) 1997-12-08 2000-07-25 Axon Engineering, Inc. Spiral nerve cuff electrode implantation tool
AU2022999A (en) 1997-12-31 1999-07-19 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US7921855B2 (en) 1998-01-07 2011-04-12 Asthmatx, Inc. Method for treating an asthma attack
US6146380A (en) 1998-01-09 2000-11-14 Radionics, Inc. Bent tip electrical surgical probe
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
CA2295134A1 (en) 1998-01-15 1999-07-22 Amethyst Technologies, Inc. Improved pulsed electromagnetic energy treatment apparatus and method
US6251130B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Device for applications of selective organ cooling
JP4373605B2 (ja) 1998-01-26 2009-11-25 ボストン サイエンティフィック リミテッド 遠方誘導結合器および埋め込み伝送路を備えたカテーテルアセンブリ
US6415187B1 (en) 1998-02-10 2002-07-02 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and insertion needle for use therewith
US6522932B1 (en) 1998-02-10 2003-02-18 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and tools for use therewith
US6205361B1 (en) 1998-02-10 2001-03-20 Advanced Bionics Corporation Implantable expandable multicontact electrodes
EP0937481A1 (en) 1998-02-19 1999-08-25 Precision Vascular Systems, Inc. Catheter or guidewire with varying flexibility
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6258087B1 (en) 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6843793B2 (en) 1998-02-24 2005-01-18 Endovia Medical, Inc. Surgical instrument
US7169141B2 (en) 1998-02-24 2007-01-30 Hansen Medical, Inc. Surgical instrument
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
CA2321671C (en) 1998-03-02 2009-07-14 Atrionix, Inc. Tissue ablation system and method for forming long linear lesion
US6308090B1 (en) 1998-03-09 2001-10-23 Irvine Biomedical, Inc. Devices and methods for coronary sinus mapping
US7674259B2 (en) 2000-12-09 2010-03-09 Tsunami Medtech Medical instruments and techniques for thermally-mediated therapies
US6142991A (en) 1998-03-31 2000-11-07 Galil Medical, Ltd. High resolution cryosurgical method and apparatus
US6200266B1 (en) 1998-03-31 2001-03-13 Case Western Reserve University Method and apparatus for ultrasound imaging using acoustic impedance reconstruction
AU3212199A (en) 1998-03-31 1999-10-18 Scimed Life Systems, Inc. Temperature controlled solute delivery system
US6086527A (en) 1998-04-02 2000-07-11 Scimed Life Systems, Inc. System for treating congestive heart failure
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6106518A (en) 1998-04-09 2000-08-22 Cryocath Technologies, Inc. Variable geometry tip for a cryosurgical ablation device
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6364856B1 (en) 1998-04-14 2002-04-02 Boston Scientific Corporation Medical device with sponge coating for controlled drug release
JP2003511098A (ja) 1998-04-14 2003-03-25 ジーエムピー・ドラツグ・デリバリー・インコーポレーテツド 動脈及び他の身体組織への局所的薬物移送のためのイオン導入、エレクトロポレーション及び組み合わせカテーテル
US6064902A (en) 1998-04-16 2000-05-16 C.R. Bard, Inc. Pulmonary vein ablation catheter
US5916154A (en) 1998-04-22 1999-06-29 Nellcor Puritan Bennett Method of enhancing performance in pulse oximetry via electrical stimulation
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
US6269269B1 (en) 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US5928272A (en) 1998-05-02 1999-07-27 Cyberonics, Inc. Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity
US6192889B1 (en) 1998-05-05 2001-02-27 Woodside Biomedical, Inc. Method of suppression and prevention of the gag reflex
US6042580A (en) 1998-05-05 2000-03-28 Cardiac Pacemakers, Inc. Electrode having composition-matched, common-lead thermocouple wire for providing multiple temperature-sensitive junctions
US6049737A (en) 1998-05-05 2000-04-11 Cardiac Pacemakers, Inc. Catheter having common lead for electrode and sensor
US6312425B1 (en) 1998-05-05 2001-11-06 Cardiac Pacemakers, Inc. RF ablation catheter tip electrode with multiple thermal sensors
US6066096A (en) 1998-05-08 2000-05-23 Duke University Imaging probes and catheters for volumetric intraluminal ultrasound imaging and related systems
AU3973599A (en) 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
US6022901A (en) 1998-05-13 2000-02-08 Pharmascience Inc. Administration of resveratrol to prevent or treat restenosis following coronary intervention
US6231572B1 (en) 1998-05-29 2001-05-15 Applied Medical Resources Corporation Electrosurgical catheter apparatus and method
US6623474B1 (en) 1998-06-04 2003-09-23 Biosense Webster, Inc. Injection catheter with needle stop
US7198635B2 (en) 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US6368316B1 (en) 1998-06-11 2002-04-09 Target Therapeutics, Inc. Catheter with composite stiffener
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6287306B1 (en) 1998-06-22 2001-09-11 Daig Corporation Even temperature linear lesion ablation catheter
US6066132A (en) 1998-06-30 2000-05-23 Ethicon, Inc. Articulating endometrial ablation device
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
CA2337652C (en) 1998-07-13 2013-03-26 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6394096B1 (en) 1998-07-15 2002-05-28 Corazon Technologies, Inc. Method and apparatus for treatment of cardiovascular tissue mineralization
US7599736B2 (en) 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6304787B1 (en) 1998-08-26 2001-10-16 Advanced Bionics Corporation Cochlear electrode array having current-focusing and tissue-treating features
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6385472B1 (en) 1999-09-10 2002-05-07 Stereotaxis, Inc. Magnetically navigable telescoping catheter and method of navigating telescoping catheter
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US7722539B2 (en) 1998-09-18 2010-05-25 University Of Washington Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US20060240070A1 (en) 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
EP1115328A4 (en) 1998-09-24 2004-11-10 Super Dimension Ltd SYSTEM AND METHOD FOR LOCATING A CATHETER DURING AN ENDOCORPOREAL MEDICAL EXAMINATION
US6283935B1 (en) 1998-09-30 2001-09-04 Hearten Medical Ultrasonic device for providing reversible tissue damage to heart muscle
US6544215B1 (en) 1998-10-02 2003-04-08 Scimed Life Systems, Inc. Steerable device for introducing diagnostic and therapeutic apparatus into the body
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6149596A (en) 1998-11-05 2000-11-21 Bancroft; Michael R. Ultrasonic catheter apparatus and method
US7313444B2 (en) 1998-11-20 2007-12-25 Pacesetter, Inc. Self-anchoring coronary sinus lead
US6319250B1 (en) 1998-11-23 2001-11-20 C.R. Bard, Inc Tricuspid annular grasp catheter
US6638278B2 (en) 1998-11-23 2003-10-28 C. R. Bard, Inc. Intracardiac grasp catheter
US6575933B1 (en) 1998-11-30 2003-06-10 Cryocath Technologies Inc. Mechanical support for an expandable membrane
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
EP1140278B1 (en) 1998-12-14 2004-05-19 Tre Esse Progettazione Biomedica S.r.l Catheter system for performing intramyocardiac therapeutic treatment
US6077227A (en) 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6206831B1 (en) 1999-01-06 2001-03-27 Scimed Life Systems, Inc. Ultrasound-guided ablation catheter and methods of use
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US7780628B1 (en) * 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US6695830B2 (en) 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
US6592526B1 (en) 1999-01-25 2003-07-15 Jay Alan Lenker Resolution ultrasound devices for imaging and treatment of body lumens
JP2002536040A (ja) 1999-02-02 2002-10-29 トランサージカル，インコーポレイテッド 体内高強度収束超音波アプリケータ
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US6210339B1 (en) 1999-03-03 2001-04-03 Endosonics Corporation Flexible elongate member having one or more electrical contacts
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
US6508774B1 (en) 1999-03-09 2003-01-21 Transurgical, Inc. Hifu applications with feedback control
ATE298536T1 (de) 1999-03-09 2005-07-15 Thermage Inc Vorichtung zur behandlung von gewebe
US6492762B1 (en) 1999-03-22 2002-12-10 Transurgical, Inc. Ultrasonic transducer, transducer array, and fabrication method
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6484052B1 (en) 1999-03-30 2002-11-19 The Regents Of The University Of California Optically generated ultrasound for enhanced drug delivery
US6911026B1 (en) 1999-07-12 2005-06-28 Stereotaxis, Inc. Magnetically guided atherectomy
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6738663B2 (en) 1999-04-09 2004-05-18 Oncostim, A Minnesota Corporation Implantable device and method for the electrical treatment of cancer
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6939346B2 (en) 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6595959B1 (en) 1999-04-23 2003-07-22 Alexander A. Stratienko Cardiovascular sheath/catheter
US6302870B1 (en) 1999-04-29 2001-10-16 Precision Vascular Systems, Inc. Apparatus for injecting fluids into the walls of blood vessels, body cavities, and the like
US6341236B1 (en) * 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
US6923784B2 (en) * 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US7226446B1 (en) 1999-05-04 2007-06-05 Dinesh Mody Surgical microwave ablation assembly
AU4696100A (en) 1999-05-04 2000-11-17 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6178352B1 (en) 1999-05-07 2001-01-23 Woodside Biomedical, Inc. Method of blood pressure moderation
US6758830B1 (en) 1999-05-11 2004-07-06 Atrionix, Inc. Catheter positioning system
US7343195B2 (en) 1999-05-18 2008-03-11 Mediguide Ltd. Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation
US6692490B1 (en) 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
DE29909082U1 (de) 1999-05-25 1999-07-22 Starck Stimulations-, Sensing- und/oder Defibrillationselektrode sowie Ballon-Katheter zum Einbringen der Elektrode
US6442424B1 (en) 1999-05-26 2002-08-27 Impulse Dynamics N.V. Local cardiac motion control using applied electrical signals
US6304777B1 (en) 1999-05-26 2001-10-16 Impulse Dynamics N.V. Induction of cardioplegia applied electrical signals
US6368346B1 (en) 1999-06-03 2002-04-09 American Medical Systems, Inc. Bioresorbable stent
US7171263B2 (en) 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US6890329B2 (en) 1999-06-15 2005-05-10 Cryocath Technologies Inc. Defined deflection structure
US6398792B1 (en) 1999-06-21 2002-06-04 O'connor Lawrence Angioplasty catheter with transducer using balloon for focusing of ultrasonic energy and method for use
US6546272B1 (en) 1999-06-24 2003-04-08 Mackinnon Nicholas B. Apparatus for in vivo imaging of the respiratory tract and other internal organs
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
JP2003503119A (ja) 1999-06-25 2003-01-28 エモリ ユニバーシティ 迷走神経刺激用機器及び方法
US6272383B1 (en) 1999-06-28 2001-08-07 Woodside Biomedical, Inc. Electro-acupuncture method using an electrical stimulator
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6927049B2 (en) 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
US7053063B2 (en) 1999-07-21 2006-05-30 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes in tissue
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US6692494B1 (en) 1999-08-05 2004-02-17 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
US6767544B2 (en) 2002-04-01 2004-07-27 Allergan, Inc. Methods for treating cardiovascular diseases with botulinum toxin
US6611720B2 (en) 1999-08-12 2003-08-26 Irvine Biomedical Inc. High torque catheter possessing multi-directional deflectability and methods thereof
US7171275B2 (en) 1999-08-12 2007-01-30 Irvine Biomedical Inc. High torque balloon catheter possessing multi-directional deflectability and methods thereof
US6246914B1 (en) 1999-08-12 2001-06-12 Irvine Biomedical, Inc. High torque catheter and methods thereof
US6450942B1 (en) 1999-08-20 2002-09-17 Cardiorest International Ltd. Method for reducing heart loads in mammals
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
AU7362400A (en) 1999-09-10 2001-04-10 Transurgical, Inc. Occlusion of tubular anatomical structures by energy application
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
WO2001022897A1 (en) 1999-09-28 2001-04-05 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
US6485489B2 (en) 1999-10-02 2002-11-26 Quantum Cor, Inc. Catheter system for repairing a mitral valve annulus
US6473644B1 (en) 1999-10-13 2002-10-29 Cyberonics, Inc. Method to enhance cardiac capillary growth in heart failure patients
US6287304B1 (en) 1999-10-15 2001-09-11 Neothermia Corporation Interstitial cauterization of tissue volumes with electrosurgically deployed electrodes
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
US20050240170A1 (en) 1999-10-25 2005-10-27 Therus Corporation Insertable ultrasound probes, systems, and methods for thermal therapy
CA2387127A1 (en) 1999-10-25 2001-05-17 Therus Corporation Use of focused ultrasound for vascular sealing
CA2389363A1 (en) 1999-10-29 2001-05-10 Universitat Zurich Method of volumetric blood flow measurement
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6711444B2 (en) 1999-11-22 2004-03-23 Scimed Life Systems, Inc. Methods of deploying helical diagnostic and therapeutic element supporting structures within the body
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
EP1106206B1 (de) * 1999-11-30 2007-06-27 BIOTRONIK GmbH & Co. KG Gerät zur Regelung der Herzfrequenz und der Herzpumpkraft
EP1106202A3 (de) 1999-11-30 2004-03-31 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Elektrode zu intravaskuläran Stimulation, Kardioversion und/oder Defibrillation
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US6415183B1 (en) 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US20030150464A1 (en) 1999-12-17 2003-08-14 Casscells S. Ward Inducing apoptosis of atrial myocytes to treat atrial fibrillation
JP2003522566A (ja) 1999-12-21 2003-07-29 シャーウッド サーヴィシス アクチェンゲゼルシャフト 椎間板の熱治療のための装置
AU2598201A (en) 1999-12-23 2001-07-03 Therus Corporation Ultrasound transducers for imaging and therapy
US6494891B1 (en) 1999-12-30 2002-12-17 Advanced Cardiovascular Systems, Inc. Ultrasonic angioplasty transmission member
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6623453B1 (en) 2000-01-19 2003-09-23 Vanny Corporation Chemo-thermo applicator for cancer treatment
US6692450B1 (en) 2000-01-19 2004-02-17 Medtronic Xomed, Inc. Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US6356787B1 (en) 2000-02-24 2002-03-12 Electro Core Techniques, Llc Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US20060085046A1 (en) 2000-01-20 2006-04-20 Ali Rezai Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system
US6438423B1 (en) 2000-01-20 2002-08-20 Electrocore Technique, Llc Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain
US6356786B1 (en) 2000-01-20 2002-03-12 Electrocore Techniques, Llc Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain
US6361531B1 (en) 2000-01-21 2002-03-26 Medtronic Xomed, Inc. Focused ultrasound ablation devices having malleable handle shafts and methods of using the same
WO2001055212A2 (en) 2000-01-27 2001-08-02 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
US6569109B2 (en) 2000-02-04 2003-05-27 Olympus Optical Co., Ltd. Ultrasonic operation apparatus for performing follow-up control of resonance frequency drive of ultrasonic oscillator by digital PLL system using DDS (direct digital synthesizer)
US6457365B1 (en) 2000-02-09 2002-10-01 Endosonics Corporation Method and apparatus for ultrasonic imaging
US6514226B1 (en) 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
US6663622B1 (en) 2000-02-11 2003-12-16 Iotek, Inc. Surgical devices and methods for use in tissue ablation procedures
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7565206B2 (en) 2000-02-17 2009-07-21 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US7499745B2 (en) 2000-02-28 2009-03-03 Barbara Ann Karmanos Cancer Institute Multidimensional bioelectrical tissue analyzer
US6394956B1 (en) 2000-02-29 2002-05-28 Scimed Life Systems, Inc. RF ablation and ultrasound catheter for crossing chronic total occlusions
US6536949B1 (en) 2000-03-07 2003-03-25 Richard R. Heuser Catheter for thermal evaluation of arteriosclerotic plaque
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6787974B2 (en) 2000-03-22 2004-09-07 Prorhythm, Inc. Ultrasound transducer unit and planar ultrasound lens
US6554774B1 (en) 2000-03-23 2003-04-29 Tensys Medical, Inc. Method and apparatus for assessing hemodynamic properties within the circulatory system of a living subject
CA2399570C (en) 2000-03-24 2009-02-10 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US6287608B1 (en) 2000-04-11 2001-09-11 Intellicardia, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator
WO2001082812A1 (en) 2000-04-27 2001-11-08 Medtronic, Inc. Vibration sensitive ablation apparatus and method
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6837886B2 (en) 2000-05-03 2005-01-04 C.R. Bard, Inc. Apparatus and methods for mapping and ablation in electrophysiology procedures
US20010044596A1 (en) * 2000-05-10 2001-11-22 Ali Jaafar Apparatus and method for treatment of vascular restenosis by electroporation
WO2001087172A1 (en) 2000-05-12 2001-11-22 Cardima, Inc. Multi-channel rf energy delivery with coagulum reduction
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
ATE290827T1 (de) 2000-06-13 2005-04-15 Atrionix Inc Chirurgische ablationssonde zum formen einer ringförmigen läsion
US6477426B1 (en) 2000-06-20 2002-11-05 Celsion Corporation System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors
US7837720B2 (en) 2000-06-20 2010-11-23 Boston Scientific Corporation Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US6405067B1 (en) 2000-07-07 2002-06-11 Biosense Webster, Inc. Catheter with tip electrode having a recessed ring electrode mounted thereon
CN1241658C (zh) 2000-07-13 2006-02-15 普罗里森姆股份有限公司 一种在存活对象的体内施加能量的装置
AU7346801A (en) 2000-07-13 2002-01-30 Transurgical Inc Energy application with inflatable annular lens
DE60017205T2 (de) 2000-07-26 2006-01-12 Advanced Bionics Corp., Sylmar Wiederaufladbare vorrichtung zur stimulation des rückenmarks
US7678106B2 (en) 2000-08-09 2010-03-16 Halt Medical, Inc. Gynecological ablation procedure and system
US7789876B2 (en) 2000-08-14 2010-09-07 Tyco Healthcare Group, Lp Method and apparatus for positioning a catheter relative to an anatomical junction
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
EP1311188A1 (en) 2000-08-24 2003-05-21 Volcano Therapeutics, Inc. Thermography catheter with flexible circuit temperature sensors
US6862479B1 (en) 2000-08-30 2005-03-01 Advanced Bionics Corporation Spinal cord stimulation as a therapy for sexual dysfunction
AU2434501A (en) 2000-09-07 2002-03-22 Sherwood Serv Ag Apparatus for and treatment of the intervertebral disc
US6405079B1 (en) 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US7499742B2 (en) 2001-09-26 2009-03-03 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7623926B2 (en) 2000-09-27 2009-11-24 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7616997B2 (en) 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US7306591B2 (en) 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US6640120B1 (en) 2000-10-05 2003-10-28 Scimed Life Systems, Inc. Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US6926669B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US8417334B2 (en) * 2000-10-26 2013-04-09 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions
US20030004549A1 (en) * 2000-10-26 2003-01-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
EP1201198A1 (en) 2000-10-27 2002-05-02 MicroNet Medical, Inc. Catheter with thin film electrodes and method for making same
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
DE50106342D1 (de) 2000-11-24 2005-06-30 Innovacell Biotechnologie Gmbh Ultraschallsonde mit positioniereinrichtung für untersuchungs- und operationsvorrichtungen
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6728563B2 (en) 2000-11-29 2004-04-27 St. Jude Medical, Daig Division, Inc. Electrophysiology/ablation catheter having “halo” configuration
US6681136B2 (en) 2000-12-04 2004-01-20 Science Medicus, Inc. Device and method to modulate blood pressure by electrical waveforms
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US6666845B2 (en) 2001-01-04 2003-12-23 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
WO2002053207A2 (en) 2001-01-04 2002-07-11 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
US6544223B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Balloon catheter for delivering therapeutic agents
WO2002054941A2 (en) 2001-01-11 2002-07-18 Rita Medical Systems Inc Bone-treatment instrument and method
US6600954B2 (en) 2001-01-25 2003-07-29 Biocontrol Medical Bcm Ltd. Method and apparatus for selective control of nerve fibers
DE10103503A1 (de) 2001-01-26 2002-08-14 Fraunhofer Ges Forschung Endoluminales expandierbares Implantat mit integrierter Sensorik
US6672312B2 (en) 2001-01-31 2004-01-06 Transurgical, Inc. Pulmonary vein ablation with myocardial tissue locating
US6564096B2 (en) * 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
US6620151B2 (en) 2001-03-01 2003-09-16 Advanced Neuromodulation Systems, Inc. Non-constant pressure infusion pump
AU2002250250A1 (en) 2001-03-01 2002-09-19 Three Arch Partners Intravascular device for treatment of hypertension
WO2002069821A1 (en) * 2001-03-06 2002-09-12 Thermemed Corp. Vaporous delivery of thermal energy to tissue sites
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
EP1379197A4 (en) * 2001-03-23 2009-06-03 Durect Corp DISPOSAL OF MEDICINAL PRODUCTS OF DELAYED RELEASE DEVICES IMPLANTED IN MYOKARD TISSUE OR PER ICARDROOM
CA2450376A1 (en) 2001-04-20 2002-10-31 The Board Of Regents Of The University Of Oklahoma Cardiac neuromodulation and methods of using same
AU2002307473A1 (en) 2001-04-20 2002-11-05 C. R. Bard, Inc. Telescoping tip electrode catheter
WO2002085192A2 (en) 2001-04-23 2002-10-31 Transurgical, Inc. Improvements in ablation therapy
US6663627B2 (en) 2001-04-26 2003-12-16 Medtronic, Inc. Ablation system and method of use
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US6972016B2 (en) 2001-05-01 2005-12-06 Cardima, Inc. Helically shaped electrophysiology catheter
US6716207B2 (en) 2001-05-22 2004-04-06 Scimed Life Systems, Inc. Torqueable and deflectable medical device shaft
CA2447643A1 (en) * 2001-05-29 2002-12-05 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
US7674245B2 (en) 2001-06-07 2010-03-09 Cardiac Pacemakers, Inc. Method and apparatus for an adjustable shape guide catheter
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US6763722B2 (en) 2001-07-13 2004-07-20 Transurgical, Inc. Ultrasonic transducers
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US20050010263A1 (en) 2001-07-27 2005-01-13 Patrick Schauerte Neurostimulation unit for immobilizing the heart during cardiosurgical operations
US20040043030A1 (en) 2001-07-31 2004-03-04 Immunomedics, Inc. Polymeric delivery systems
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US6622041B2 (en) * 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US20030050635A1 (en) 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
US7778703B2 (en) * 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
WO2003020915A2 (en) 2001-08-31 2003-03-13 Cyto Pulse Sciences, Inc. Non-linear amplitude dielectrophoresis waveform for cell fusion
US6962588B2 (en) 2001-08-31 2005-11-08 Boston Scientific Scimed, Inc. Percutaneous pringle occlusion method and device
US6547803B2 (en) 2001-09-20 2003-04-15 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
US7547294B2 (en) 2001-09-20 2009-06-16 The Regents Of The University Of California Microfabricated surgical device for interventional procedures
AU2002327779B2 (en) 2001-09-28 2008-06-26 Angiodynamics, Inc. Impedance controlled tissue ablation apparatus and method
WO2003028802A2 (en) 2001-10-01 2003-04-10 Am Discovery, Incorporated Devices for treating atrial fibrilation
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US20070038056A1 (en) 2001-10-11 2007-02-15 Carlo Pappone System and methods for locating and ablating arrhythomogenic tissues
US20030082225A1 (en) 2001-10-19 2003-05-01 Mason Paul Arthur Sterile, breathable patch for treating wound pain
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
US6807444B2 (en) 2001-11-05 2004-10-19 Hosheng Tu Apparatus and methods for monitoring tissue impedance
US6745079B2 (en) 2001-11-07 2004-06-01 Medtronic, Inc. Electrical tissue stimulation apparatus and method
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
ATE375127T1 (de) 2001-11-29 2007-10-15 Medwaves Inc Hochfrequenz-kathetersystem mit verbesserten ablenkungs- und steuermechanismen
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
US6849075B2 (en) 2001-12-04 2005-02-01 Estech, Inc. Cardiac ablation devices and methods
US6748255B2 (en) 2001-12-14 2004-06-08 Biosense Webster, Inc. Basket catheter with multiple location sensors
US20030125790A1 (en) 2001-12-27 2003-07-03 Vitaly Fastovsky Deployment device, system and method for medical implantation
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
AU2003209287A1 (en) 2002-01-15 2003-07-30 The Regents Of The University Of California System and method providing directional ultrasound therapy to skeletal joints
US20060189941A1 (en) 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
US20030171734A1 (en) 2002-01-22 2003-09-11 Endobionics, Inc. Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
US7744584B2 (en) 2002-01-22 2010-06-29 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
US7819826B2 (en) 2002-01-23 2010-10-26 The Regents Of The University Of California Implantable thermal treatment method and apparatus
US7155284B1 (en) 2002-01-24 2006-12-26 Advanced Bionics Corporation Treatment of hypertension
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
JP2005516697A (ja) 2002-02-01 2005-06-09 ザ クリーブランド クリニック ファウンデイション 独立的に移動可能な伝達構造を備えた神経刺激伝達デバイス
WO2003063692A2 (en) 2002-02-01 2003-08-07 The Cleveland Clinic Foundation Delivery device for stimulating the sympathetic nerve chain
WO2003066155A2 (en) 2002-02-01 2003-08-14 The Cleveland Clinic Foundation Methods of affecting hypothalamic-related conditions
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US20070078620A1 (en) 2002-02-13 2007-04-05 Mercator Medsystems Inc. Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
US7236821B2 (en) 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US6733499B2 (en) 2002-02-28 2004-05-11 Biosense Webster, Inc. Catheter having circular ablation assembly
US6824516B2 (en) 2002-03-11 2004-11-30 Medsci Technologies, Inc. System for examining, mapping, diagnosing, and treating diseases of the prostate
WO2003076008A1 (en) 2002-03-14 2003-09-18 Brainsgate Ltd. Technique for blood pressure regulation
US6882885B2 (en) 2002-03-19 2005-04-19 Solarant Medical, Inc. Heating method for tissue contraction
US6736835B2 (en) 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
AU2003220574A1 (en) 2002-03-27 2003-10-13 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8347891B2 (en) * 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20070129761A1 (en) * 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
AU2003223583A1 (en) 2002-04-11 2003-10-27 Transvascular, Inc. Devices and methods for transluminal or transthoracic interstitial electrode placement
WO2003089046A1 (en) 2002-04-16 2003-10-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199767A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030236443A1 (en) 2002-04-19 2003-12-25 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199768A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20040147828A1 (en) 2002-04-22 2004-07-29 Gibson Charles A. Telescoping tip electrode catheter
US7141041B2 (en) 2003-03-19 2006-11-28 Mercator Medsystems, Inc. Catheters having laterally deployable needles
DE10218426A1 (de) 2002-04-24 2003-11-06 Biotronik Mess & Therapieg Ablationsvorrichtung für Herzgewebe, insbesondere zur Erzeugung linearer Läsionen zwischen zwei Gefäßmündungen im Herzen
US20030204161A1 (en) 2002-04-25 2003-10-30 Bozidar Ferek-Petric Implantable electroporation therapy device and method for using same
US6746401B2 (en) 2002-05-06 2004-06-08 Scimed Life Systems, Inc. Tissue ablation visualization
AU2003245344A1 (en) 2002-05-28 2003-12-12 Endobionics, Inc. Methods and apparatus for aspiration and priming of inflatable structures in catheters
US7153315B2 (en) 2002-06-11 2006-12-26 Boston Scientific Scimed, Inc. Catheter balloon with ultrasonic microscalpel blades
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
JP2004016333A (ja) 2002-06-13 2004-01-22 Unique Medical Co Ltd 硬膜外麻酔用カテーテルおよび該硬膜外麻酔用カテーテルを用いる電気刺激装置
JP3813112B2 (ja) 2002-06-26 2006-08-23 テルモ株式会社 カテーテルおよび医療用チューブ
US7465298B2 (en) 2002-06-28 2008-12-16 Mercator Medsystems, Inc. Methods and systems for delivering liquid substances to tissues surrounding body lumens
US20130197555A1 (en) 2002-07-01 2013-08-01 Recor Medical, Inc. Intraluminal devices and methods for denervation
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
WO2004004572A1 (en) 2002-07-08 2004-01-15 Prorhythm, Inc. Cardiac ablation using microbubbles
US6866662B2 (en) 2002-07-23 2005-03-15 Biosense Webster, Inc. Ablation catheter having stabilizing array
US7914467B2 (en) 2002-07-25 2011-03-29 Boston Scientific Scimed, Inc. Tubular member having tapered transition for use in a medical device
US8920826B2 (en) 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US6702748B1 (en) 2002-09-20 2004-03-09 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US20040024392A1 (en) 2002-08-05 2004-02-05 Lewis James D. Apparatus and method for cryosurgery
US6893414B2 (en) 2002-08-12 2005-05-17 Breg, Inc. Integrated infusion and aspiration system and method
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
WO2004018031A2 (en) 2002-08-22 2004-03-04 William A. Cook Australia Pty. Ltd. Guide wire
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US7328069B2 (en) 2002-09-06 2008-02-05 Medtronic, Inc. Method, system and device for treating disorders of the pelvic floor by electrical stimulation of and the delivery of drugs to the left and right pudendal nerves
US20040193228A1 (en) 2003-03-31 2004-09-30 Gerber Martin T. Method, system and device for treating various disorders of the pelvic floor by electrical stimulation of the left and right pudendal nerves
US6780183B2 (en) 2002-09-16 2004-08-24 Biosense Webster, Inc. Ablation catheter having shape-changing balloon
US6808524B2 (en) 2002-09-16 2004-10-26 Prorhythm, Inc. Balloon alignment and collapsing system
US7189229B2 (en) 2002-09-16 2007-03-13 Prorhythm, Inc. Balloon alignment and collapsing system
WO2004107965A2 (en) 2002-09-20 2004-12-16 Flowmedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
AU2003276903A1 (en) 2002-09-20 2004-05-04 Flowmedica, Inc. Method and apparatus for selective material delivery via an intra-renal catheter
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
US7150741B2 (en) 2002-09-20 2006-12-19 Advanced Neuromodulation Systems, Inc. Programmable dose control module
WO2005037105A1 (en) 2002-09-20 2005-04-28 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
WO2004026371A2 (en) 2002-09-20 2004-04-01 Flowmedica, Inc. Method and apparatus for selective drug infusion via an intraaortic flow diverter delivery catheter
WO2004034767A2 (en) 2002-09-20 2004-04-29 Flowmedica, Inc. Catheter system for renal therapy
EP1542739B1 (en) 2002-09-26 2008-12-10 Angiotech International Ag Perivascular wraps
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
US7599737B2 (en) 2002-10-04 2009-10-06 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
ATE458534T1 (de) 2002-10-04 2010-03-15 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
DE10252325B4 (de) 2002-11-11 2012-10-25 Admedes Schuessler Gmbh Sonde zur Hochfrequenz-Thermoablation sowie Verfahren zu deren Herstellung
DE10257146A1 (de) 2002-12-06 2004-06-24 Admedes Schuessler Gmbh Metallelektrode
US7599730B2 (en) 2002-11-19 2009-10-06 Medtronic Navigation, Inc. Navigation system for cardiac therapies
ITBS20020107A1 (it) 2002-11-25 2004-05-26 Invatec Srl Tubo metallico con almeno una parte di lunghezza a flessibilita' variabile.
US20040106952A1 (en) 2002-12-03 2004-06-03 Lafontaine Daniel M. Treating arrhythmias by altering properties of tissue
US7195628B2 (en) 2002-12-11 2007-03-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Atrial fibrillation therapy with pulmonary vein support
US20040162590A1 (en) 2002-12-19 2004-08-19 Whitehurst Todd K. Fully implantable miniature neurostimulator for intercostal nerve stimulation as a therapy for angina pectoris
WO2004062470A2 (en) 2003-01-03 2004-07-29 Advanced Neuromodulation Systems, Inc. System and method for stimulation of a person’s brain stem
WO2004060448A2 (en) 2003-01-03 2004-07-22 Ekos Corporation Ultrasonic catheter with axial energy field
WO2004062525A2 (en) 2003-01-16 2004-07-29 Galil Medical Ltd. Device, system, and method for detecting and localizing obstruction within a blood vessel
KR20050098277A (ko) 2003-01-29 2005-10-11 이-필 파마 리미티드 위장관 내 약물의 능동 송달
US8066700B2 (en) 2003-01-31 2011-11-29 Smith & Nephew, Inc. Cartilage treatment probe
US7167750B2 (en) 2003-02-03 2007-01-23 Enteromedics, Inc. Obesity treatment with electrically induced vagal down regulation
US20040193211A1 (en) 2003-02-14 2004-09-30 Voegele James W. Fingertip surgical instruments
US7201749B2 (en) 2003-02-19 2007-04-10 Biosense, Inc. Externally-applied high intensity focused ultrasound (HIFU) for pulmonary vein isolation
WO2004073505A2 (en) 2003-02-20 2004-09-02 Prorhythm, Inc. Cardiac ablation devices
AU2004216229B2 (en) 2003-02-21 2010-12-09 Electro-Cat, Llc System and method for measuring cross-sectional areas and pressure gradients in luminal organs
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
US20040163655A1 (en) 2003-02-24 2004-08-26 Plc Systems Inc. Method and catheter system applicable to acute renal failure
US7004911B1 (en) 2003-02-24 2006-02-28 Hosheng Tu Optical thermal mapping for detecting vulnerable plaque
US20040176699A1 (en) 2003-03-03 2004-09-09 Volcano Therapeutics, Inc. Thermography catheter with improved wall contact
WO2004078066A2 (en) 2003-03-03 2004-09-16 Sinus Rhythm Technologies, Inc. Primary examiner
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7686802B2 (en) 2003-03-28 2010-03-30 C.R. Bard, Inc. Junction of catheter tip and electrode
US7938828B2 (en) 2003-03-28 2011-05-10 Boston Scientific Scimed, Inc. Cooled ablation catheter
US20040213770A1 (en) 2003-04-22 2004-10-28 Endobionics, Inc. Methods and systems for treating ischemic cardiac and other tissues
US7517342B2 (en) 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
CA2524163C (en) 2003-05-02 2012-01-03 Boston Scientific Limited Multi-functional medical catheter
EP1620164B1 (en) 2003-05-06 2007-04-11 Enpath Medical, Inc. Rotatable lead introducer
JP2004337400A (ja) 2003-05-16 2004-12-02 Terumo Corp 薬剤投与キット
DE10323566B4 (de) 2003-05-26 2006-03-23 Fehling Ag Instrument zur unipolaren Ablation von Herzgewebe
AU2004251673B2 (en) 2003-06-04 2010-01-28 Synecor Llc Intravascular electrophysiological system and methods
JP2006526464A (ja) 2003-06-05 2006-11-24 フローメディカ，インコーポレイテッド 分枝した身体管腔において両側介入または診断を行うためのシステムおよび方法
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
WO2004110258A2 (en) 2003-06-10 2004-12-23 Cardiofocus, Inc. Guided cardiac ablation catheters
US20080208169A1 (en) 2003-06-11 2008-08-28 Boyle Edward M Jr Body-Space Treatment Catheter
US20060167437A1 (en) 2003-06-17 2006-07-27 Flowmedica, Inc. Method and apparatus for intra aortic substance delivery to a branch vessel
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
US7066895B2 (en) 2003-06-30 2006-06-27 Ethicon, Inc. Ultrasonic radial focused transducer for pulmonary vein ablation
US7678123B2 (en) 2003-07-14 2010-03-16 Nmt Medical, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
US8034294B1 (en) 2003-07-15 2011-10-11 Ideal Life, Inc. Medical monitoring/consumables tracking device
US20060269531A1 (en) 2003-07-18 2006-11-30 Eastern Virginia Medical School Apparatus for generating electrical pulses and methods of using the same
US7670335B2 (en) 2003-07-21 2010-03-02 Biosense Webster, Inc. Ablation device with spiral array ultrasound transducer
EP1659970A4 (en) 2003-08-05 2008-05-21 Flowmedica Inc SYSTEM AND METHOD FOR PREVENTING RADIO CONTRAST-INDUCED NEPHROPATHY
US7294125B2 (en) 2003-08-22 2007-11-13 Scimed Life Systems, Inc. Methods of delivering energy to body portions to produce a therapeutic response
US7742809B2 (en) 2003-08-25 2010-06-22 Medtronic, Inc. Electroporation catheter with sensing capabilities
US7313430B2 (en) 2003-08-28 2007-12-25 Medtronic Navigation, Inc. Method and apparatus for performing stereotactic surgery
US7766868B2 (en) 2003-09-05 2010-08-03 Medtronic, Inc. Deflectable medical therapy delivery device having common lumen profile
US7156843B2 (en) 2003-09-08 2007-01-02 Medtronic, Inc. Irrigated focal ablation tip
AU2004285412A1 (en) 2003-09-12 2005-05-12 Minnow Medical, Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
CN1287800C (zh) * 2003-09-20 2006-12-06 昆明紫健生物技术有限公司 调节神经系统、治疗癫痫病的药物
US7502650B2 (en) 2003-09-22 2009-03-10 Cvrx, Inc. Baroreceptor activation for epilepsy control
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US7998112B2 (en) 2003-09-30 2011-08-16 Abbott Cardiovascular Systems Inc. Deflectable catheter assembly and method of making same
US7591813B2 (en) 2003-10-01 2009-09-22 Micrus Endovascular Corporation Long nose manipulatable catheter
US20050153885A1 (en) 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
US7186209B2 (en) 2003-10-09 2007-03-06 Jacobson Jerry I Cardioelectromagnetic treatment
US7416549B2 (en) 2003-10-10 2008-08-26 Boston Scientific Scimed, Inc. Multi-zone bipolar ablation probe assembly
WO2005037070A2 (en) 2003-10-11 2005-04-28 The Regents Of The University Of California Method and system for nerve repair, nanoknife, mems platform and uses thereof
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
CA2536168A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US20080015659A1 (en) 2003-12-24 2008-01-17 Yi Zhang Neurostimulation systems and methods for cardiac conditions
US8396560B2 (en) 2004-11-18 2013-03-12 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
JP5138229B2 (ja) 2003-12-24 2013-02-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 不可逆的電気穿孔による組織アブレーション
US7486991B2 (en) 2003-12-24 2009-02-03 Cardiac Pacemakers, Inc. Baroreflex modulation to gradually decrease blood pressure
US7273469B1 (en) 2003-12-31 2007-09-25 Advanced Cardiovascular Systems, Inc. Modified needle catheter for directional orientation delivery
JP4970049B2 (ja) 2003-12-31 2012-07-04 バイオセンス・ウエブスター・インコーポレーテツド ２つの可膨張性部材を備えた周囲切除装置アセンブリ
US7637903B2 (en) 2004-02-09 2009-12-29 Cryocor, Inc. Catheter articulation segment with alternating cuts
US20050182479A1 (en) 2004-02-13 2005-08-18 Craig Bonsignore Connector members for stents
US7245955B2 (en) 2004-02-23 2007-07-17 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having deflection assembly
US20050203410A1 (en) 2004-02-27 2005-09-15 Ep Medsystems, Inc. Methods and systems for ultrasound imaging of the heart from the pericardium
US7499747B2 (en) 2004-03-02 2009-03-03 Cvrx, Inc. External baroreflex activation
US7662114B2 (en) 2004-03-02 2010-02-16 Focus Surgery, Inc. Ultrasound phased arrays
WO2005091910A2 (en) 2004-03-04 2005-10-06 Flowmedica, Inc. Sheath for use in peripheral interventions
US7976539B2 (en) 2004-03-05 2011-07-12 Hansen Medical, Inc. System and method for denaturing and fixing collagenous tissue
US8052636B2 (en) 2004-03-05 2011-11-08 Hansen Medical, Inc. Robotic catheter system and methods
US7247141B2 (en) 2004-03-08 2007-07-24 Ethicon Endo-Surgery, Inc. Intra-cavitary ultrasound medical system and method
US20050209548A1 (en) 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
US7854733B2 (en) 2004-03-24 2010-12-21 Biosense Webster, Inc. Phased-array for tissue treatment
US20050214268A1 (en) 2004-03-25 2005-09-29 Cavanagh William A Iii Methods for treating tumors and cancerous tissues
US8007495B2 (en) 2004-03-31 2011-08-30 Biosense Webster, Inc. Catheter for circumferential ablation at or near a pulmonary vein
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US20060018949A1 (en) 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
CA2502018A1 (en) 2004-04-16 2005-10-16 Conor Medsystems, Inc. Bioresorbable stent delivery system
CA2563817C (en) 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
EP1750799A2 (en) 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US20050251116A1 (en) 2004-05-05 2005-11-10 Minnow Medical, Llc Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter
US8412348B2 (en) 2004-05-06 2013-04-02 Boston Scientific Neuromodulation Corporation Intravascular self-anchoring integrated tubular electrode body
EP1750506A4 (en) 2004-05-14 2010-03-17 Flowmedica Inc BILATERAL LOCAL RENAL DELIVERY FOR THE TREATMENT OF CONGESTIVE HEART FAILURE AND BNP THERAPY
US7758564B2 (en) 2004-05-14 2010-07-20 Ethicon Endo-Surgery, Inc. Medical instrument having a catheter and a medical guidewire
US20050261672A1 (en) 2004-05-18 2005-11-24 Mark Deem Systems and methods for selective denervation of heart dysrhythmias
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
US7632265B2 (en) 2004-05-28 2009-12-15 St. Jude Medical, Atrial Fibrillation Division, Inc. Radio frequency ablation servo catheter and method
WO2005123183A2 (en) 2004-06-11 2005-12-29 University Of South Florida Electroporation device and method for delivery to ocular tissue
US20060004346A1 (en) 2004-06-17 2006-01-05 Begg John D Bend relief
US7640046B2 (en) 2004-06-18 2009-12-29 Cardiac Pacemakers, Inc. Methods and apparatuses for localizing myocardial infarction during catheterization
US7197354B2 (en) 2004-06-21 2007-03-27 Mediguide Ltd. System for determining the position and orientation of a catheter
US20060067972A1 (en) 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
US20060004417A1 (en) 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
WO2006012050A2 (en) 2004-06-30 2006-02-02 Cvrx, Inc. Connection structures for extra-vascular electrode lead body
US7850675B2 (en) 2004-07-20 2010-12-14 Boston Scientific Scimed, Inc. Reinforced venous access catheter
FR2873385B1 (fr) 2004-07-23 2006-10-27 Centre Nat Rech Scient Cnrse Surveillance et controle d'une electroporation
JP2008508024A (ja) * 2004-07-28 2008-03-21 アーディアン インコーポレイテッド 腎神経ブロッキング方法及び装置
US7373204B2 (en) 2004-08-19 2008-05-13 Lifestim, Inc. Implantable device and method for treatment of hypertension
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
EP1796568A1 (en) 2004-09-09 2007-06-20 Vnus Medical Technologies, Inc. Methods and apparatus for treatment of hollow anatomical structures
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US7742795B2 (en) 2005-03-28 2010-06-22 Minnow Medical, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
EP1804907A2 (en) 2004-09-10 2007-07-11 The Cleveland Clinic Foundation Methods and systems of achieving hemodynamic control through neuromodulation
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US7753906B2 (en) 2004-09-14 2010-07-13 Richard Esposito Catheter having anchoring and stabilizing devices
US20060069323A1 (en) 2004-09-24 2006-03-30 Flowmedica, Inc. Systems and methods for bi-lateral guidewire cannulation of branched body lumens
US20060069385A1 (en) 2004-09-28 2006-03-30 Scimed Life Systems, Inc. Methods and apparatus for tissue cryotherapy
US20060074453A1 (en) 2004-10-04 2006-04-06 Cvrx, Inc. Baroreflex activation and cardiac resychronization for heart failure treatment
WO2006044738A2 (en) 2004-10-18 2006-04-27 Maroon Biotech Corporation Methods and compositions for treatment of free radical injury
US7524318B2 (en) 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes
US7753907B2 (en) 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20070083239A1 (en) 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US8409191B2 (en) 2004-11-04 2013-04-02 Boston Scientific Scimed, Inc. Preshaped ablation catheter for ablating pulmonary vein ostia within the heart
US7949407B2 (en) 2004-11-05 2011-05-24 Asthmatx, Inc. Energy delivery devices and methods
WO2006052940A2 (en) 2004-11-05 2006-05-18 Asthmatx, Inc. Medical device with procedure improvement features
US20060100618A1 (en) 2004-11-08 2006-05-11 Cardima, Inc. System and method for performing ablation and other medical procedures using an electrode array with flex circuit
US20060129128A1 (en) 2004-11-15 2006-06-15 Sampson Russel M Method and system for drug delivery
US8034050B2 (en) 2004-11-15 2011-10-11 Biosense Webster, Inc. Catheter with microfabricated temperature sensing
JP5020824B2 (ja) 2004-11-16 2012-09-05 ロバート・エル・バリー 肺治療の装置及び方法
US8332047B2 (en) 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
CA2587780A1 (en) 2004-11-18 2006-05-26 Transpharma Medical Ltd. Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents
US20060116720A1 (en) 2004-12-01 2006-06-01 Penny Knoblich Method and apparatus for improving renal function
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
EP1835964B1 (en) 2004-12-21 2016-03-09 EBR Systems, Inc. Leadless cardiac system for pacing and arrhythmia treatment
US20060155269A1 (en) 2005-01-12 2006-07-13 Prorhythm, Inc. Epicardial ablation using focused ultrasound
US9833618B2 (en) 2005-02-04 2017-12-05 Palo Alto Investors Methods and compositions for treating a disease condition in a subject
US8007440B2 (en) 2005-02-08 2011-08-30 Volcano Corporation Apparatus and methods for low-cost intravascular ultrasound imaging and for crossing severe vascular occlusions
US20060182873A1 (en) 2005-02-17 2006-08-17 Klisch Leo M Medical devices
US7548780B2 (en) 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
US8801701B2 (en) 2005-03-09 2014-08-12 Sunnybrook Health Sciences Centre Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment
EP2327429B1 (en) 2005-03-23 2014-09-17 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US7727187B2 (en) 2005-04-04 2010-06-01 Cook Incorporated Scored catheter device
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US20060241523A1 (en) 2005-04-12 2006-10-26 Prorhythm, Inc. Ultrasound generating method, apparatus and probe
JP5188389B2 (ja) 2005-05-05 2013-04-24 ボストン サイエンティフィック リミテッド 肺静脈口を画像として再構築する予成形した位置確認カテーテル及びシステム
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
DE102005023303A1 (de) 2005-05-13 2006-11-16 Celon Ag Medical Instruments Biegeweiche Applikationsvorrichtung zur Hochfrequenztherapie von biologischem Gewebe
CN101180040B (zh) 2005-05-20 2012-10-10 奥默罗斯公司 环加氧酶抑制剂和钙通道拮抗剂组合物以及供泌尿科操作使用的方法
US20060270976A1 (en) 2005-05-31 2006-11-30 Prorhythm, Inc. Steerable catheter
US20060270975A1 (en) 2005-05-31 2006-11-30 Prorhythm, Inc. Steerable catheter
US7573182B2 (en) 2005-06-01 2009-08-11 Prorhythm, Inc. Ultrasonic transducer
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US7850685B2 (en) 2005-06-20 2010-12-14 Medtronic Ablation Frontiers Llc Ablation catheter
WO2007002304A2 (en) 2005-06-22 2007-01-04 Vnus Medical Technologies, Inc. Methods and apparatus for introducing tumescent fluid to body tissue
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
AU2006266149B2 (en) 2005-06-30 2012-04-12 Rox Medical, Inc. Devices, systems, and methods for creation of a peripherally located fistula
EP1909679B1 (en) 2005-07-11 2013-11-20 Medtronic Ablation Frontiers LLC Low power tissue ablation system
DE102005032755B4 (de) 2005-07-13 2014-09-04 Siemens Aktiengesellschaft System zur Durchführung und Überwachung minimal-invasiver Eingriffe
US20070066897A1 (en) 2005-07-13 2007-03-22 Sekins K M Systems and methods for performing acoustic hemostasis of deep bleeding trauma in limbs
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US8862243B2 (en) 2005-07-25 2014-10-14 Rainbow Medical Ltd. Electrical stimulation of blood vessels
CA2616760C (en) 2005-07-26 2014-10-07 Rox Medical, Inc. Devices, systems, and methods for peripheral arteriovenous fistula creation
US7591996B2 (en) 2005-08-17 2009-09-22 University Of Washington Ultrasound target vessel occlusion using microbubbles
CN2855350Y (zh) 2005-09-01 2007-01-10 迈德医疗科技（上海）有限公司 用于射频消融治疗探针电极装置
SG165337A1 (en) 2005-09-09 2010-10-28 Ottawa Hospital Res Inst Interpenetrating networks, and related methods and compositions
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US20070208134A1 (en) 2005-10-03 2007-09-06 Hunter William L Anti-scarring drug combinations and use thereof
US20070299043A1 (en) 2005-10-03 2007-12-27 Hunter William L Anti-scarring drug combinations and use thereof
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
US8257338B2 (en) 2006-10-27 2012-09-04 Artenga, Inc. Medical microbubble generation
EP1782852A1 (de) 2005-11-04 2007-05-09 F.Hoffmann-La Roche Ag Anordnung zum automatisierten Zuführen eines flüssigen Medikamentes in den Körper eines Patienten
KR100778142B1 (ko) 2005-11-09 2007-11-29 황창모 신체조직의 선택적 제거를 위한 방사주파수 전극체
US7747324B2 (en) 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US7686768B2 (en) 2005-11-23 2010-03-30 Vital Sensors Holding Company, Inc. Implantable pressure monitor
US8190238B2 (en) 2005-12-09 2012-05-29 Hansen Medical, Inc. Robotic catheter system and methods
US20080045890A1 (en) 2005-12-16 2008-02-21 Mercator Medsystems, Inc. Methods and systems for ablating tissue
US8050774B2 (en) 2005-12-22 2011-11-01 Boston Scientific Scimed, Inc. Electrode apparatus, systems and methods
US20070156200A1 (en) 2005-12-29 2007-07-05 Lilian Kornet System and method for regulating blood pressure and electrolyte balance
AU2007210060A1 (en) 2006-01-27 2007-08-09 Medtronic, Inc. Ablation device with lockout feature
EP1988941A2 (en) 2006-01-31 2008-11-12 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US7662151B2 (en) 2006-02-15 2010-02-16 Boston Scientific Scimed, Inc. Contact sensitive probes
US7918850B2 (en) 2006-02-17 2011-04-05 Biosense Wabster, Inc. Lesion assessment by pacing
US8571650B2 (en) 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US7894905B2 (en) 2006-03-13 2011-02-22 Neuropace, Inc. Implantable system enabling responsive therapy for pain
US20070219576A1 (en) 2006-03-16 2007-09-20 Medtronic Vascular, Inc. Reversibly and Radially Expandable Electroactive Polymer Element for Temporary Occlusion of a Vessel
US7579550B2 (en) 2006-03-31 2009-08-25 Boston Scientific Scimed, Inc. Flexible device shaft with angled spiral wrap
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
CA2649119A1 (en) 2006-04-13 2007-12-13 Mirabilis Medica, Inc. Methods and apparatus for the treatment of menometrorrhagia, endometrial pathology, and cervical neoplasia using high intensity focused ultrasound energy
US8401650B2 (en) 2008-04-10 2013-03-19 Electrocore Llc Methods and apparatus for electrical treatment using balloon and electrode
US20070255270A1 (en) 2006-04-27 2007-11-01 Medtronic Vascular, Inc. Intraluminal guidance system using bioelectric impedance
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
EP2540246B8 (en) 2006-05-12 2020-10-07 Vytronus, Inc. Device for ablating body tissue
US20100198065A1 (en) 2009-01-30 2010-08-05 VyntronUS, Inc. System and method for ultrasonically sensing and ablating tissue
US7725157B2 (en) 2006-05-16 2010-05-25 General Electric Company System and method for interventional procedures using MRI
US20070269385A1 (en) 2006-05-18 2007-11-22 Mercator Medsystems, Inc Devices, methods, and systems for delivering therapeutic agents for the treatment of sinusitis, rhinitis, and other disorders
US10499937B2 (en) 2006-05-19 2019-12-10 Recor Medical, Inc. Ablation device with optimized input power profile and method of using the same
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20080004596A1 (en) 2006-05-25 2008-01-03 Palo Alto Institute Delivery of agents by microneedle catheter
US7615067B2 (en) 2006-06-05 2009-11-10 Cambridge Endoscopic Devices, Inc. Surgical instrument
US20070282376A1 (en) 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US7647101B2 (en) 2006-06-09 2010-01-12 Cardiac Pacemakers, Inc. Physical conditioning system, device and method
US20070287994A1 (en) 2006-06-12 2007-12-13 Pankaj Amrit Patel Endoscopically Introducible Expandable Bipolar Probe
US20080097251A1 (en) 2006-06-15 2008-04-24 Eilaz Babaev Method and apparatus for treating vascular obstructions
EP2092957B2 (en) 2006-06-28 2019-11-20 Medtronic Ardian Luxembourg S.à.r.l. Systems for thermally-induced renal neuromodulation
EP2049184B1 (en) 2006-07-26 2013-02-13 Johan Willem Pieter Marsman Facilitation of antegrade insertion of a guidewire into the superficial femoral artery
US7708704B2 (en) 2006-07-31 2010-05-04 Codman & Shurtleff, Pc Interventional medical device component having an interrupted spiral section and method of making the same
US20080039904A1 (en) 2006-08-08 2008-02-14 Cherik Bulkes Intravascular implant system
US20090221955A1 (en) 2006-08-08 2009-09-03 Bacoustics, Llc Ablative ultrasonic-cryogenic methods
US20080039727A1 (en) 2006-08-08 2008-02-14 Eilaz Babaev Ablative Cardiac Catheter System
US7674253B2 (en) 2006-08-18 2010-03-09 Kensey Nash Corporation Catheter for conducting a procedure within a lumen, duct or organ of a living being
US20080051704A1 (en) 2006-08-28 2008-02-28 Patel Rajnikant V Catheter and system for using same
WO2008031033A2 (en) 2006-09-07 2008-03-13 Spence Paul A Ultrasonic implant, systems and methods related to diverting material in blood flow away from the head
US8119183B2 (en) 2006-09-11 2012-02-21 Enbio Limited Method of doping surfaces
WO2008034030A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Magnetized bioerodible endoprosthesis
US7691080B2 (en) 2006-09-21 2010-04-06 Mercator Medsystems, Inc. Dual modulus balloon for interventional procedures
US7869874B2 (en) 2006-09-25 2011-01-11 G&L Consulting, Llc Methods and apparatus to stimulate heart atria
US8641660B2 (en) 2006-10-04 2014-02-04 P Tech, Llc Methods and devices for controlling biologic microenvironments
US20080091255A1 (en) 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
EP2455034B1 (en) 2006-10-18 2017-07-19 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
JP5479901B2 (ja) 2006-10-18 2014-04-23 べシックス・バスキュラー・インコーポレイテッド 身体組織に対する所望の温度作用の誘発
CA2666661C (en) 2006-10-18 2015-01-20 Minnow Medical, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
US7744618B2 (en) 2006-12-07 2010-06-29 Cardiac Pacemakers, Inc. Device and method for modulating renal function
US20080249419A1 (en) 2006-12-12 2008-10-09 Sekins K Michael Time-of-flight triangulation based methods of device spatial registration for multiple-transducer therapeutic ultrasound systems
US8052610B2 (en) 2006-12-28 2011-11-08 Medtronic, Inc. Event registration for automatic threshold setting
US7955326B2 (en) 2006-12-29 2011-06-07 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure-sensitive conductive composite electrode and method for ablation
US8226648B2 (en) 2007-12-31 2012-07-24 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure-sensitive flexible polymer bipolar electrode
KR20090121292A (ko) 2007-02-22 2009-11-25 라모트 앳 텔-아비브 유니버시티 리미티드 취약한 플레이크 또는 동맥류와 같은 약해진 혈관벽의 치료
US20080208162A1 (en) 2007-02-26 2008-08-28 Joshi Ashok V Device and Method For Thermophoretic Fluid Delivery
US20080221448A1 (en) 2007-03-07 2008-09-11 Khuri-Yakub Butrus T Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions
US10166066B2 (en) 2007-03-13 2019-01-01 University Of Virginia Patent Foundation Epicardial ablation catheter and method of use
EP2131925A2 (en) 2007-03-30 2009-12-16 Koninklijke Philips Electronics N.V. Mri-guided hifu marking to guide radiotherapy and other procedures
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
US8187267B2 (en) 2007-05-23 2012-05-29 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter with flexible tip and methods of making the same
US9259233B2 (en) 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US10183183B2 (en) 2007-04-13 2019-01-22 Acoustic Medsystems, Inc. Acoustic applicators for controlled thermal modification of tissue
DE102007018277A1 (de) 2007-04-18 2008-10-30 Medical Service Gmbh Katheter-Set
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
EP2139416B1 (en) 2007-05-09 2015-08-19 Irvine Biomedical, Inc. Basket catheter having multiple electrodes
US8588885B2 (en) 2007-05-09 2013-11-19 St. Jude Medical, Atrial Fibrillation Division, Inc. Bendable catheter arms having varied flexibility
AU2008291763A1 (en) 2007-05-23 2009-03-05 Oscillon Ltd. Apparatus and method for guided chronic total occlusion penetration
US11395694B2 (en) 2009-05-07 2022-07-26 St. Jude Medical, Llc Irrigated ablation catheter with multiple segmented ablation electrodes
WO2008151001A2 (en) 2007-05-30 2008-12-11 The Cleveland Clinic Foundation Method for treating a renal disease or disorder
US20080312673A1 (en) 2007-06-05 2008-12-18 Viswanathan Raju R Method and apparatus for CTO crossing
US8263104B2 (en) 2007-06-08 2012-09-11 Northwestern University Polymer nanofilm coatings
US8630704B2 (en) 2007-06-25 2014-01-14 Cardiac Pacemakers, Inc. Neural stimulation with respiratory rhythm management
US8864675B2 (en) 2007-06-28 2014-10-21 W. L. Gore & Associates, Inc. Catheter
US8702609B2 (en) 2007-07-27 2014-04-22 Meridian Cardiovascular Systems, Inc. Image-guided intravascular therapy catheters
US8353900B2 (en) 2007-08-08 2013-01-15 Boston Scientific Scimed, Inc. Miniature circular mapping catheter
US8147416B2 (en) 2007-08-31 2012-04-03 Pacesetter, Inc. Implantable systemic blood pressure measurement systems and methods
US9283034B2 (en) 2007-09-26 2016-03-15 Retrovascular, Inc. Recanalization system using radiofrequency energy
EP2211701A1 (en) 2007-10-26 2010-08-04 St. Jude Medical Systems AB Sensor guide wire with micro-cable winding
US20090118620A1 (en) 2007-11-06 2009-05-07 General Electric Company System and method for tracking an ultrasound catheter
WO2009065078A1 (en) 2007-11-14 2009-05-22 Pathway Medical Technologies, Inc. Delivery and administration of compositions using interventional catheters
WO2009065058A1 (en) 2007-11-16 2009-05-22 Boston Scientific Scimed, Inc. Apparatus for drug release in tissue ablation procedures
US20090131798A1 (en) 2007-11-19 2009-05-21 Minar Christopher D Method and apparatus for intravascular imaging and occlusion crossing
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
WO2009086007A1 (en) 2007-12-21 2009-07-09 St. Jude Medical, Atrial Fibrillation Division, Inc. Longitudinally incompressible, laterally flexible interior shaft for catheter
US7985215B2 (en) 2007-12-28 2011-07-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Deflectable catheter with distal deflectable segment
US9204927B2 (en) 2009-05-13 2015-12-08 St. Jude Medical, Atrial Fibrillation Division, Inc. System and method for presenting information representative of lesion formation in tissue during an ablation procedure
US8676322B2 (en) 2008-01-30 2014-03-18 Boston Scientific Neuromodulation Corporation Methods and systems of treating pancreatitis pain
WO2009099550A1 (en) 2008-02-07 2009-08-13 Cardiac Pacemakers, Inc. Wireless tissue electrostimulation
WO2009108997A1 (en) 2008-03-03 2009-09-11 Mk International Pty Ltd Catheter with friction reducing surface shaping
US20090228003A1 (en) 2008-03-04 2009-09-10 Prorhythm, Inc. Tissue ablation device using radiofrequency and high intensity focused ultrasound
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
EP2106821B1 (en) 2008-03-31 2019-04-17 Dentsply IH AB Catheter assembly comprising a tubular member having pleated regions, and methods of activating and manufacturing the same
JP4362536B2 (ja) 2008-04-11 2009-11-11 日本ライフライン株式会社 カテーテル
DE102008019827A1 (de) 2008-04-19 2009-10-29 Biotronik Crm Patent Ag Steuerbare Elektrode zur tiefen Hirnstimulation
US20090264755A1 (en) 2008-04-22 2009-10-22 National Taiwan University High-Intensity Ultrasonic Vessel Ablator Using Blood Flow Signal for Precise Positioning
US7956613B2 (en) 2008-05-02 2011-06-07 The General Hospital Corporation Method for imaging acoustically induced rotary saturation with a magnetic resonance imaging system
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
US20090306651A1 (en) 2008-06-09 2009-12-10 Clint Schneider Catheter assembly with front-loaded tip
JP2010021134A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd リチウム複合金属酸化物の製造方法
JP5636363B2 (ja) 2008-06-13 2014-12-03 ディージェイティー、 エルエルシー 衝撃波バルーンカテーテル装置
US20090312693A1 (en) 2008-06-13 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US20100152582A1 (en) 2008-06-13 2010-06-17 Vytronus, Inc. Handheld system and method for delivering energy to tissue
US9155588B2 (en) 2008-06-13 2015-10-13 Vytronus, Inc. System and method for positioning an elongate member with respect to an anatomical structure
US20090312673A1 (en) 2008-06-14 2009-12-17 Vytronus, Inc. System and method for delivering energy to tissue
US20100004632A1 (en) 2008-07-03 2010-01-07 Kirk Kochin Wu Magnetic guided ablation catheter
US20100049099A1 (en) 2008-07-18 2010-02-25 Vytronus, Inc. Method and system for positioning an energy source
US10363057B2 (en) 2008-07-18 2019-07-30 Vytronus, Inc. System and method for delivering energy to tissue
US20100022989A1 (en) 2008-07-25 2010-01-28 Parasmo Ronald S Steerable catheter and method of making the same
AU2009282740A1 (en) 2008-08-21 2010-02-25 Med-El Elektromedizinische Geraete Gmbh Multipath stimulation hearing systems
US8172831B2 (en) 2008-09-02 2012-05-08 Abbott Cardiovascular Systems Inc. Catheter configured for incremental rotation
US20100069837A1 (en) 2008-09-16 2010-03-18 Boston Scientific Scimed, Inc. Balloon Assembly and Method for Therapeutic Agent Delivery
US20100069882A1 (en) 2008-09-18 2010-03-18 Boston Scientific Scimed, Inc. Medical device with preferential bending
JP5622729B2 (ja) 2008-09-22 2014-11-12 べシックス・バスキュラー・インコーポレイテッド 身体組織に対して温度効果を誘発するシステム
EP2349440B1 (en) 2008-10-07 2019-08-21 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US20100099952A1 (en) 2008-10-22 2010-04-22 Boston Scientific Scimed, Inc. Steerable Shaft Having Micromachined Tube
US8414508B2 (en) 2008-10-30 2013-04-09 Vytronus, Inc. System and method for delivery of energy to tissue while compensating for collateral tissue
US9033885B2 (en) 2008-10-30 2015-05-19 Vytronus, Inc. System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion
US9192789B2 (en) 2008-10-30 2015-11-24 Vytronus, Inc. System and method for anatomical mapping of tissue and planning ablation paths therein
CN104068933B (zh) 2008-11-11 2017-03-15 施菲姆德控股有限责任公司 小外形的电极组件
WO2013154775A1 (en) 2012-04-10 2013-10-17 Covidien Lp Energy delivery device and methods of manufacturing
US8475379B2 (en) 2008-11-17 2013-07-02 Vytronus, Inc. Systems and methods for ablating body tissue
CN102271603A (zh) 2008-11-17 2011-12-07 明诺医学股份有限公司 得知或未得知组织形态的选择性能量积累
ES2447291T3 (es) 2008-11-17 2014-03-11 Vytronus, Inc. Sistema para la ablación de tejido corporal
US8317810B2 (en) 2008-12-29 2012-11-27 St. Jude Medical, Atrial Fibrillation Division, Inc. Tissue puncture assemblies and methods for puncturing tissue
US9352174B2 (en) 2008-12-30 2016-05-31 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation system with blood leakage minimization and tissue protective capabilities
US8712550B2 (en) 2008-12-30 2014-04-29 Biosense Webster, Inc. Catheter with multiple electrode assemblies for use at or near tubular regions of the heart
US8123721B2 (en) 2008-12-31 2012-02-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Catheter having independently-deflectable segments and method of its manufacture
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
WO2010080886A1 (en) 2009-01-09 2010-07-15 Recor Medical, Inc. Methods and apparatus for treatment of mitral valve in insufficiency
JP2012515024A (ja) 2009-01-15 2012-07-05 キャスリックス リミテッド 操向可能なスタイレット
US20100191232A1 (en) 2009-01-27 2010-07-29 Boveda Marco Medical Llc Catheters and methods for performing electrophysiological interventions
US8725228B2 (en) 2009-02-20 2014-05-13 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
WO2010096347A1 (en) 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Asymmetric dual directional steerable catheter sheath
US20100249702A1 (en) 2009-03-24 2010-09-30 Abbott Cardiovascular Systems Inc. Porous catheter balloon and method of making same
US20100249604A1 (en) 2009-03-31 2010-09-30 Boston Scientific Corporation Systems and methods for making and using a motor distally-positioned within a catheter of an intravascular ultrasound imaging system
NZ619320A (en) 2009-04-22 2015-08-28 Mercator Medsystems Inc Use of guanethidine for treating hypertension by local vascular delivery
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US8282633B2 (en) 2009-06-15 2012-10-09 Olympus Medical Systems Corp. High-frequency surgical apparatus and high-frequency surgical method for closure of patent foramen ovale
CN104548316B (zh) 2009-06-24 2018-01-26 施菲姆德控股有限责任公司 可转向医疗输送装置及使用方法
US20100331760A1 (en) 2009-06-30 2010-12-30 Boston Scientific Scimed, Inc. Biodegradable implant for treating or preventing reperfusion injury
US8435228B2 (en) 2009-08-12 2013-05-07 Medrad, Inc. Interventional catheter assemblies incorporating guide wire brake and management systems
US9439721B2 (en) 2009-08-25 2016-09-13 Medtronic Ablation Frontiers Llc Bi-modal linear and loop ablation catheter, and method
US20110071400A1 (en) 2009-09-23 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using intravascular ultrasound imaging systems with sealed imaging cores
US20110071401A1 (en) 2009-09-24 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using a stepper motor for an intravascular ultrasound imaging system
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
AU2010307029B2 (en) 2009-10-12 2014-07-31 Otsuka Medical Devices Co., Ltd. Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US20110257563A1 (en) 2009-10-26 2011-10-20 Vytronus, Inc. Methods and systems for ablating tissue
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
WO2011059792A1 (en) 2009-10-29 2011-05-19 Sound Interventions, Inc. Method and apparatus for treatment of cardiac valve insufficiency
CN102596320B (zh) 2009-10-30 2016-09-07 瑞蔻医药有限公司 通过经皮超声波去肾神经治疗高血压的方法和装置
WO2011053772A1 (en) 2009-10-30 2011-05-05 Sound Interventions, Inc. Method and apparatus for non-invasive treatment of hypertension through ultrasound renal denervation
EP2496165B1 (en) 2009-11-04 2017-01-11 Emcision Limited Lumenal remodelling device
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
AU2010319333B2 (en) 2009-11-13 2014-02-20 St. Jude Medical, Inc. Assembly of staggered ablation elements
US20110137155A1 (en) 2009-12-09 2011-06-09 Boston Scientific Scimed, Inc. Delivery device for localized delivery of a therapeutic agent
EP2332607A1 (en) 2009-12-14 2011-06-15 The Royal College of Surgeons in Ireland A urethral catheter
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
US20110270238A1 (en) 2009-12-31 2011-11-03 Raed Rizq Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries
EP2525715A4 (en) 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY
US20160008387A9 (en) 2010-01-26 2016-01-14 Northwind Medical, Inc. Agents and devices for affecting nerve function
WO2013063331A1 (en) 2011-10-26 2013-05-02 Stein Emily A Agents, methods, and devices for affecting nerve function
CA2787062C (en) 2010-01-26 2017-07-11 Michael A. Evans Methods, devices, and agents for denervation
WO2013169741A1 (en) 2012-05-08 2013-11-14 Stein Emily A Agents and devices for affecting nerve function
US8382672B2 (en) 2010-03-12 2013-02-26 Claire Andrews Macro/micro duty cycle devices, systems, and methods employing low-frequency ultrasound or other cyclical pressure energies
WO2011119857A2 (en) 2010-03-24 2011-09-29 Shifamed, Llc Intravascular tissue disruption
EP2552530A1 (en) 2010-03-31 2013-02-06 Boston Scientific Scimed, Inc. Guidewire with a flexural rigidity profile
US20110257562A1 (en) 2010-04-01 2011-10-20 Alan Schaer Method and apparatus employing ultrasound energy to remodulate vascular nerves
US20110301587A1 (en) 2010-04-06 2011-12-08 Innovative Pulmonary Solutions, Inc. System and method for pulmonary treatment
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
WO2011130534A2 (en) 2010-04-14 2011-10-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
EP2560703A2 (en) 2010-04-20 2013-02-27 MiniPumps, LLC Electrolytically driven drug pump devices
CA2796865A1 (en) 2010-04-26 2011-11-10 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
JP5792802B2 (ja) 2010-05-12 2015-10-14 シファメド・ホールディングス・エルエルシー 低い外形の電極組立体
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US20120029496A1 (en) 2010-07-30 2012-02-02 Scott Smith Renal nerve ablation using mild freezing and microwave energy
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
WO2012033860A1 (en) 2010-09-07 2012-03-15 Boston Scientific Scimed, Inc. Self-powered ablation catheter for renal denervation
US20120065506A1 (en) 2010-09-10 2012-03-15 Scott Smith Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation
US20120089134A1 (en) 2010-10-11 2012-04-12 Christopher Horvath Contactless Photodisruptive Laser assisted Cataract Surgery
US20130218054A1 (en) 2010-10-18 2013-08-22 CardioSonic Ltd. Separation device for ultrasound element
US8585601B2 (en) 2010-10-18 2013-11-19 CardioSonic Ltd. Ultrasound transducer
US9566456B2 (en) 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
WO2012052926A2 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Tissue treatment
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
US20120109021A1 (en) 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US20120123261A1 (en) 2010-11-16 2012-05-17 Jenson Mark L Renal Nerve Ablation Using Mild Freezing and Vibration
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
JP6046631B2 (ja) 2010-11-19 2016-12-21 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経の検出切除装置
US9192435B2 (en) 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US20120157992A1 (en) 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
EP2645955B1 (en) 2010-12-01 2016-10-26 Boston Scientific Scimed, Inc. Expandable angular vascular electrode for renal nerve ablation
US10016233B2 (en) 2010-12-06 2018-07-10 Biosense Webster (Israel) Ltd. Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120232409A1 (en) 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
CN203354638U (zh) 2010-12-21 2013-12-25 泰尔茂株式会社 气囊导管及通电系统
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
US20120191079A1 (en) 2011-01-20 2012-07-26 Hansen Medical, Inc. System and method for endoluminal and translumenal therapy
US20140163540A1 (en) 2011-02-18 2014-06-12 Recor Medical, Inc. Apparatus for effecting renal denervation using ultrasound
US8791132B2 (en) 2011-02-18 2014-07-29 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
CN103764225B (zh) 2011-03-04 2017-06-09 彩虹医疗公司 通过施加能量对组织进行治疗和监测的仪器
WO2012122157A1 (en) 2011-03-07 2012-09-13 Tidal Wave Technology, Inc. Radiofrequency ablation catheter device
CN202069688U (zh) 2011-03-11 2011-12-14 北京天助畅运医疗技术股份有限公司 治疗顽固性高血压的射频消融电极
EP2521593B1 (en) 2011-03-15 2015-12-09 Kona Medical, Inc. Energetic modulation of nerves
EP2677953A4 (en) 2011-03-31 2014-10-08 Tidal Wave Technology Inc RADIO FREQUENCY ABLATION CATHETER DEVICE
WO2012130337A1 (en) 2011-04-01 2012-10-04 Flux Medical N.V. System, device and method for ablation of a vessel's wall from the inside
JP5763263B2 (ja) 2011-04-08 2015-08-12 コビディエン エルピー 天然または人工管腔のための可撓性マイクロ波カテーテル
US20120259269A1 (en) 2011-04-08 2012-10-11 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US8545409B2 (en) 2011-04-14 2013-10-01 St. Jude Medical, Inc. Arrangement and interface for RF ablation system with acoustic feedback
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
EP2701795B1 (en) 2011-04-28 2020-12-09 Interventional Autonomics Corporation Neuromodulation systems for treating acute heart failure syndromes
CN109288789A (zh) 2011-04-28 2019-02-01 阿布拉科斯生物科学有限公司 纳米颗粒组合物的血管内递送及其应用
CN102274074A (zh) 2011-05-03 2011-12-14 上海微创电生理医疗科技有限公司 多极开放式射频消融导管
US8909316B2 (en) 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
US20120296232A1 (en) 2011-05-18 2012-11-22 St. Jude Medical, Inc. Method and apparatus of assessing transvascular denervation
EP2709517B1 (en) 2011-05-18 2017-01-11 St. Jude Medical, Inc. Apparatus for assessing transvascular denervation
WO2012170482A1 (en) 2011-06-06 2012-12-13 St. Jude Medical, Inc. Renal denervation system and method
EP2706938A4 (en) 2011-06-15 2014-11-26 Tidal Wave Technology Inc CATHETER DEVICE FOR ABLATION BY HIGH FREQUENCY
US9028470B2 (en) 2011-06-17 2015-05-12 University Of Utah Research Foundation Image-guided renal nerve ablation
JP5166576B2 (ja) 2011-07-07 2013-03-21 シャープ株式会社 ＧａＮ系半導体素子の製造方法
CA2878396A1 (en) 2011-07-11 2013-02-28 Interventional Autonomics Corporation System and method for neuromodulation
WO2013009977A1 (en) 2011-07-12 2013-01-17 David Lambert Device for reducing renal sympathetic nerve activity
CN103987334A (zh) 2011-07-12 2014-08-13 沃夫医药公司 经由肾盂的肾神经去神经支配
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
WO2013014583A1 (en) 2011-07-22 2013-01-31 Koninklijke Philips Electronics N.V. Ablation apparatus
WO2013019762A2 (en) 2011-07-31 2013-02-07 SCANLON, John, James Filamentous bioresorbable stent
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US20130274674A1 (en) 2011-08-24 2013-10-17 Ablative Solutions, Inc. Intravascular ablation catheter with precision depth of penetration calibration
US20130053732A1 (en) 2011-08-24 2013-02-28 Richard R. Heuser Devices and methods for treating hypertension with energy
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US20130274673A1 (en) 2011-08-24 2013-10-17 Ablative Solutions, Inc. Intravascular ablation catheter with enhanced fluoroscopic visibility
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
US20140200489A1 (en) 2011-09-01 2014-07-17 Perseus-Biomed Inc Method and system for tissue modulation
US9603659B2 (en) 2011-09-14 2017-03-28 Boston Scientific Scimed Inc. Ablation device with ionically conductive balloon
CN103987336A (zh) 2011-09-14 2014-08-13 波士顿科学西美德公司 具有多种消融模式的消融装置
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
CN106823131B (zh) 2011-09-30 2019-12-20 柯惠有限合伙公司 能量传递装置以及使用方法
JP6522942B2 (ja) 2011-10-04 2019-05-29 べシックス・バスキュラー・インコーポレイテッド ステント内再狭窄を治療するためのシステム及び方法
US20130090578A1 (en) 2011-10-10 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
EP2765942B1 (en) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US20130090647A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Ablation catheter with insulated tip
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US20130096550A1 (en) 2011-10-18 2013-04-18 Boston Scientific Scimed, Inc. Ablative catheter with electrode cooling and related methods of use
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
AU2012325893B2 (en) 2011-10-19 2015-04-16 Sympara Medical Inc. Methods and devices for treating hypertension
BR112014009634A2 (pt) 2011-10-19 2017-05-09 Mercator Medsystems Inc preparação e agente terapêutico
CN102551874B (zh) 2011-10-20 2015-07-22 上海微创电生理医疗科技有限公司 肾动脉射频消融导管
US20130110106A1 (en) 2011-10-28 2013-05-02 Boston Scientific Scimed, Inc. Expandable structure for off-wall ablation electrode
EP2775948B1 (en) 2011-11-08 2018-04-04 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
WO2013074661A2 (en) 2011-11-14 2013-05-23 Boston Scientific Scimed, Inc. Integrated ultrasound ablation and imaging device and related methods
EP2779929A1 (en) 2011-11-15 2014-09-24 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
WO2013074218A1 (en) 2011-11-15 2013-05-23 Boston Scientific Scimed, Inc. Shaft with ultrasound transducers for nerve modulation
US20140350553A1 (en) 2011-11-21 2014-11-27 Denerve Inc. Renal artery ablation catheter and system
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
CN202386778U (zh) 2011-11-29 2012-08-22 北京天助畅运医疗技术股份有限公司 射频消融装置
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
US20130158509A1 (en) 2011-12-19 2013-06-20 Paul M. Consigny System, apparatus, and method for denervating an artery
US9131980B2 (en) 2011-12-19 2015-09-15 Medtronic Advanced Energy Llc Electrosurgical devices
CN202426647U (zh) 2011-12-22 2012-09-12 王涛 可变直径网篮多极点射频消融电极
WO2013096913A2 (en) 2011-12-23 2013-06-27 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US20130172877A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Balloon expandable multi-electrode rf ablation catheter
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US20130172880A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for renal nerve modulation
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US8825130B2 (en) 2011-12-30 2014-09-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrode support structure assemblies
US20130184703A1 (en) 2012-01-17 2013-07-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for making and using the same
WO2013111136A2 (en) 2012-01-25 2013-08-01 CardioSonic Ltd. Selective reduction of nerve activity
EP3915629A1 (en) 2012-01-26 2021-12-01 Autonomix Medical, Inc. Controlled sympathectomy and micro-ablation systems and methods
EP2809399B1 (en) 2012-01-30 2023-04-19 Auris Health, Inc. Tissue necrosis apparatus
US9089341B2 (en) 2012-02-28 2015-07-28 Surefire Medical, Inc. Renal nerve neuromodulation device
US20130231659A1 (en) 2012-03-01 2013-09-05 Boston Scientific Scimed, Inc. Off-wall and contact electrode devices and methods for nerve modulation
US20130231658A1 (en) 2012-03-01 2013-09-05 Boston Scientific Scimed, Inc. Expandable ablation device and methods for nerve modulation
AU2013202803C1 (en) 2012-03-07 2016-06-23 Reshape Lifesciences, Inc. Devices for regulation of blood pressure and heart rate
CN104284636A (zh) 2012-03-19 2015-01-14 波士顿科学西美德公司 用于神经调制的可膨胀的电极装置和方法
US20130253628A1 (en) 2012-03-22 2013-09-26 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
WO2013150777A1 (ja) 2012-04-05 2013-10-10 テルモ株式会社 血管挿入型治療デバイス
US9439598B2 (en) 2012-04-12 2016-09-13 NeuroMedic, Inc. Mapping and ablation of nerves within arteries and tissues
US10357304B2 (en) 2012-04-18 2019-07-23 CardioSonic Ltd. Tissue treatment
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
US20130289650A1 (en) 2012-04-25 2013-10-31 Pacesetter, Inc. Neuromodulation for Hypertension Control
US20130289369A1 (en) 2012-04-27 2013-10-31 Volcano Corporation Methods and Apparatus for Renal Neuromodulation
US20130289686A1 (en) 2012-04-29 2013-10-31 Synecor Llc Intravascular electrode arrays for neuromodulation
US20130296836A1 (en) 2012-05-02 2013-11-07 Enigma Medical, Inc. System and method of pre-aortic ganglion ablation
WO2013165935A1 (en) 2012-05-03 2013-11-07 Sound Interventions, Inc. Apparatus and method for uniform renal denervation
US20140207136A1 (en) 2012-05-04 2014-07-24 St. Jude Medical, Inc. Multiple staggered electrodes connected via flexible joints
US20150094787A1 (en) 2012-05-08 2015-04-02 Mayo Foundation For Medical Education And Research Methods and materials for treating syncope
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
WO2013177430A1 (en) 2012-05-23 2013-11-28 Sunnybrook Health Sciences Centre Multi-frequency ultrasound device and method of operation
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
US8562573B1 (en) 2012-06-05 2013-10-22 Fischell Innovations, Llc Guiding catheter for accessing the renal arteries
WO2013188689A1 (en) 2012-06-13 2013-12-19 Harrington Douglas C Devices and methods for renal denervation
US9642673B2 (en) 2012-06-27 2017-05-09 Shockwave Medical, Inc. Shock wave balloon catheter with multiple shock wave sources
WO2014012053A1 (en) 2012-07-13 2014-01-16 Boston Scientific Scimed, Inc. Off -wall electrode devices for nerve modulation
US20140018888A1 (en) 2012-07-16 2014-01-16 Boston Scientific Scimed, Inc. Flow controlled radiofrequency medical balloon
US20140025069A1 (en) 2012-07-17 2014-01-23 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
CN102743225B (zh) 2012-07-18 2014-04-02 深圳市惠泰医疗器械有限公司 肾动脉射频消融可控电极导管
CA2878588A1 (en) 2012-07-30 2014-02-06 Northwestern University Radiofrequency probe for circumferential ablation of a hollow cavity
US20140067003A1 (en) 2012-07-31 2014-03-06 Abhi Vase System and method for autonomic blood pressure regulation
US9237984B2 (en) 2012-08-10 2016-01-19 Shockwave Medical, Inc. Shockwave nerve therapy system and method
US9033917B2 (en) 2012-08-15 2015-05-19 Abbott Cardiovascular Systems Inc. Needle catheter for delivery of agents directly into vessel wall
US9987086B2 (en) 2012-08-22 2018-06-05 Boston Scientific Scimed, Inc. Multiple electrode RF ablation catheter and method
US20150315188A1 (en) 2012-08-22 2015-11-05 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
US20140067029A1 (en) 2012-08-28 2014-03-06 Boston Scientific Scimed, Inc. Renal nerve modulation and ablation catheter electrode design
CN102908189B (zh) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN202761434U (zh) 2012-08-29 2013-03-06 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN102908188B (zh) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经射频消融导管系统
WO2014056460A1 (zh) 2012-08-29 2014-04-17 第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
CN102885649B (zh) 2012-08-29 2015-01-21 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经射频线控消融导管系统
CN102885648B (zh) 2012-08-29 2015-03-18 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经消融导管系统
CN202843784U (zh) 2012-08-29 2013-04-03 中国人民解放军第三军医大学第一附属医院 肾脏去交感神经消融导管系统
CN104768487A (zh) 2012-09-13 2015-07-08 波士顿科学西美德公司 肾脏神经调节球囊及其制造和使用方法
JP2014054430A (ja) 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
JP6074051B2 (ja) 2012-10-10 2017-02-01 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 血管内神経変調システム及び医療用デバイス
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US8740849B1 (en) 2012-10-29 2014-06-03 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US9554849B2 (en) 2012-10-29 2017-01-31 Ablative Solutions, Inc. Transvascular method of treating hypertension
CN105263431A (zh) 2012-11-02 2016-01-20 纽敦力公司 用于多种疾病治疗的化学消融制剂和方法
US10537375B2 (en) 2015-04-24 2020-01-21 Neurotronic, Inc. Chemical ablation and method of treatment for various diseases
WO2014071223A1 (en) 2012-11-02 2014-05-08 Vessix Vascular, Inc. Flex circuit/balloon assemblies utilizing textured surfaces for enhanced bonding
CN104902836B (zh) 2012-11-05 2017-08-08 毕达哥拉斯医疗有限公司 受控组织消融
WO2014070999A2 (en) 2012-11-05 2014-05-08 Landy Toth Systems, methods, and devices for monitoring and treatment of tissues within and/or through a lumen wall
US20140128734A1 (en) 2012-11-05 2014-05-08 Ekos Corporation Catheter systems and methods
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
US10286182B2 (en) 2012-11-12 2019-05-14 Boston Scientific Scimed, Inc. Renal catheter shaft design
US10272269B2 (en) 2012-11-13 2019-04-30 Silk Road Medical, Inc. Devices and methods for endoluminal delivery of either fluid or energy for denervation
US20140316496A1 (en) 2012-11-21 2014-10-23 NeuroTronik IP Holding (Jersey) Limited Intravascular Electrode Arrays for Neuromodulation
US10238875B2 (en) 2012-12-19 2019-03-26 Adi Mashiach Systems and methods for hypertension control
WO2014100226A1 (en) 2012-12-21 2014-06-26 Huennekens Scott Tissue ablation catheter and methods of ablating tissue
US20140188103A1 (en) 2012-12-31 2014-07-03 Volcano Corporation Methods and Apparatus for Neuromodulation Utilizing Optical-Acoustic Sensors
WO2014110579A1 (en) 2013-01-14 2014-07-17 Boston Scientific Scimed, Inc. Renal nerve ablation catheter
AU2014210802A1 (en) 2013-01-31 2015-07-23 Renal Dynamics Ltd. Ablation catheter with insulation
US20140228829A1 (en) 2013-02-13 2014-08-14 St. Jude Medical, Cardiology Division, Inc. Laser-based devices and methods for renal denervation
US10195467B2 (en) 2013-02-21 2019-02-05 Boston Scientific Scimed, Inc. Ablation catheter system with wireless radio frequency temperature sensor
US20140249524A1 (en) 2013-03-01 2014-09-04 Boston Scientific Scimed, Inc. System and method for performing renal nerve modulation
US20140246465A1 (en) 2013-03-03 2014-09-04 Joan Darnell Peterson Fish n stow
US20140303617A1 (en) 2013-03-05 2014-10-09 Neuro Ablation, Inc. Intravascular nerve ablation devices & methods
AU2014225622A1 (en) 2013-03-08 2015-09-17 Symple Surgical Inc. Balloon catheter apparatus with microwave emitter
EP2964086A4 (en) 2013-03-09 2017-02-15 Kona Medical, Inc. Transducers, systems, and manufacturing techniques for focused ultrasound therapies
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
EP2968931B1 (en) 2013-03-12 2022-03-16 Boston Scientific Scimed, Inc. Medical systems and methods for modulating nerves
US9861431B2 (en) 2013-03-13 2018-01-09 Kyphon SÀRL Radiofrequency inflatable device
US9510902B2 (en) 2013-03-13 2016-12-06 St. Jude Medical, Cardiology Division, Inc. Ablation catheters and systems including rotational monitoring means
CN105188587A (zh) 2013-03-13 2015-12-23 波士顿科学医学有限公司 具有线性离子化传导性气球的可转向消融设备
US20140276050A1 (en) 2013-03-13 2014-09-18 Boston Scientific Scimed, Inc. Ultrasound renal nerve ablation and imaging catheter with dual-function transducers
EP3799931A1 (en) 2013-03-14 2021-04-07 ReCor Medical, Inc. Ultrasound-based neuromodulation system
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US20140271717A1 (en) 2013-03-14 2014-09-18 Kyphon Sarl Devices containing a chemical denervation agent and methods for treating chronic back pain using chemical denervation
US9108030B2 (en) 2013-03-14 2015-08-18 Covidien Lp Fluid delivery catheter with pressure-actuating needle deployment and retraction
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
US9028488B2 (en) 2013-03-14 2015-05-12 Kyphon Sarl Radio frequency catheter to target ligamentum flavum
US9561070B2 (en) 2013-03-15 2017-02-07 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
US11179193B2 (en) 2013-03-15 2021-11-23 St. Jude Medical, Atrial Fibrillation Division, Inc. Device for intravascular therapy and/or diagnosis
US20140276714A1 (en) 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Active infusion sheath for ultrasound ablation catheter
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
US9974477B2 (en) 2013-03-15 2018-05-22 St. Jude Medical, Cardiology Division, Inc. Quantification of renal denervation via alterations in renal blood flow pre/post ablation
US9775663B2 (en) 2013-03-15 2017-10-03 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
US9333113B2 (en) 2013-03-15 2016-05-10 Abbott Cardiovascular Systems Inc. System and method for denervation
US9186212B2 (en) 2013-03-15 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods utilizing two or more sites along denervation catheter
US20140276756A1 (en) 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Wall-sparing renal nerve ablation catheter with spaced electrode structures
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
US9173701B2 (en) 2013-03-15 2015-11-03 Warsaw Orthopedic, Inc. RF enabled inflatable bone tamp
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
WO2014176205A1 (en) 2013-04-25 2014-10-30 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system
WO2014179768A1 (en) 2013-05-02 2014-11-06 Harrington Douglas C Devices and methods for detection and treatment of the aorticorenal ganglion
US10390879B2 (en) 2013-05-20 2019-08-27 Mayo Foundation For Medical Education And Research Devices and methods for ablation of tissue
US20140350551A1 (en) 2013-05-21 2014-11-27 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system
WO2014188430A2 (en) 2013-05-23 2014-11-27 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
US9814618B2 (en) 2013-06-06 2017-11-14 Boston Scientific Scimed, Inc. Devices for delivering energy and related methods of use
US9737306B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Implantable luminal devices
US9943365B2 (en) 2013-06-21 2018-04-17 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
US20150005799A1 (en) 2013-06-27 2015-01-01 Boston Scientific Scimed, Inc. Renal nerve modulation balloon having improved robustness
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
US20150105772A1 (en) 2013-10-14 2015-04-16 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
EP3057520A1 (en) 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Medical device balloon
JP6259099B2 (ja) 2013-10-18 2018-01-10 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 可撓性を備える導電性ワイヤを備えるバルーン・カテーテル、並びに関連する使用および製造方法
US10856936B2 (en) 2013-10-23 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including thermoplastic-based struts
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
EP3060148A4 (en) 2013-10-25 2017-06-21 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US20150305974A1 (en) 2014-04-24 2015-10-29 Sympara Medical, Inc. Methods and devices for treating hypertension

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US10179235B2 (en) 2002-04-08 2019-01-15 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
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US10850091B2 (en) 2002-04-08 2020-12-01 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for bilateral renal neuromodulation
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US9456869B2 (en) 2016-10-04
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US9320561B2 (en) 2016-04-26
US8150519B2 (en) 2012-04-03
US20120197198A1 (en) 2012-08-02
US20140288531A1 (en) 2014-09-25
US9265558B2 (en) 2016-02-23
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US20190175903A1 (en) 2019-06-13
US9486270B2 (en) 2016-11-08
US20150080885A1 (en) 2015-03-19
US20180078758A1 (en) 2018-03-22
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US20060265014A1 (en) 2006-11-23

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