CN101489607B - A medical delivery system with flexible blocking element - Google Patents

A medical delivery system with flexible blocking element Download PDF

Info

Publication number
CN101489607B
CN101489607B CN2007800266605A CN200780026660A CN101489607B CN 101489607 B CN101489607 B CN 101489607B CN 2007800266605 A CN2007800266605 A CN 2007800266605A CN 200780026660 A CN200780026660 A CN 200780026660A CN 101489607 B CN101489607 B CN 101489607B
Authority
CN
China
Prior art keywords
container
parts
clamp device
rotatable element
quantitative assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800266605A
Other languages
Chinese (zh)
Other versions
CN101489607A (en
Inventor
V·A·克里斯琴森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority claimed from PCT/EP2007/057283 external-priority patent/WO2008009646A1/en
Publication of CN101489607A publication Critical patent/CN101489607A/en
Application granted granted Critical
Publication of CN101489607B publication Critical patent/CN101489607B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3135—Syringe barrels characterised by constructional features of the proximal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes

Abstract

A medical delivery system (100) having a container (102) and a dosing assembly (104), and wherein one of the container and the dosing assembly comprises a rotatable element (106) adapted to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system. A dosing assembly suitable for use in said medical delivery system.

Description

Medical delivery system with flexible blocking element
Technical field
The present invention relates to a kind of medical delivery system that comprises container and quantitative assembly.Particularly, the present invention relates to medical delivery system, wherein in container and the quantitative assembly comprise be suitable for container and quantitative assembly in another rotatable element that engages.In addition, the present invention relates to a kind of container and quantitative assembly, this container is suitable for according in the medical delivery system of the present invention with each of quantitative assembly.
Background technology
Usually, for the good doser of being accepted fully by the particular patients ' crowd probably is provided, released more multifarious drug-supplying system to patients'benefit.Along with the increase of the quantity of the induction system that can commercial buy, scattered many different types of drugs and kept tube or container.The major part of the container of these types is different in many aspects.
Each medicine container can be full of the particular agent type of from a variety of different medicaments, selecting, and different types of similar medicament (for example fast or protamine zine insulin) and every kind of particular agent of variable concentrations can be contained in the container.
In addition, thus can introduce different vessel volumes so that customize each container customization induction system to specific user's demand.The variation of vessel volume can realize through the length or the diameter that change container.These changes mean the corresponding change of quantitative assembly of drug-supplying system usually, thus with the driving element of the given stroke that is provided for spraying from container medicament or best quantitative accuracy is provided.Difference between the different in addition medicine containers possibly caused such as the required sliding friction that is contained in the piston in the container by the design requirement of each particular delivery system.
In order between a greater variety of containers capable of using, to distinguish, developed the electronic reading of many main dependence special container and the container coding system of identification, carry the medicament of particular type so that allow through special conveyer device.In the prior art, following mechanical coding system is known:
US 5611783 relates to a kind of pen-injected that comprises distal portion and close end, and this distal portion can comprise ampoule, and this close end contains dosage setting and driving mechanism.Near-end and distal portion have interlocking bayonet socket coupling arrangement.Excrescence can be set guarantee the pattern that specific distal portion only can be used in combination with specific proximal portion with formation.
WO 03/017915A1 discloses a kind of tube with far-end, and this far-end is provided with mechanical coding.This mechanical coding has the form of circular excrescence, and wherein circular outer diameter is specifically designed to the insulin that is contained in the certain concentration in the tube.
US 5693027 discloses and a kind ofly has been used to make standard cartridge to be suitable for the vinyl cover of selected syringe.This vinyl cover can be provided with and be used for keying in the device that engages with the related device of syringe, with when tube is installed in the syringe, keeps vinyl cover non-rotatable.In the syringe of some types, tube engages with this key entry between the syringe also be used to guarantee only to use particular type tin.
US 6648859B2 discloses a kind of cartridge assembly, is used for using with the handwriting assembly that can utilize again of administration pen.Use for fear of intersecting, handwriting assembly and cartridge case are locked, promptly they can come threads engage through respective threads and groove, bayonet socket screw thread and groove, collocation or a pair of lug plate that cooperates with anti-Luer-Lock mode.Select the coupling member preventing the use that intersects with other assembly, but for example the pitch angulation of screw thread does not match with other assembly so that only match each other.
Another prior art system is open in DE 20110690.
The purpose of the preferred embodiments of the present invention is for system known per a kind of alternative to be provided.And the purpose of the preferred embodiments of the present invention provides has a large amount of possible geometric drug-supplying systems of coding.
In addition; The purpose of the preferred embodiments of the present invention provides a kind of coding system; Wherein when the container that will be scheduled to medical delivery system and quantitative assembly be coupled to each other/when separating; User experiences the fastening motion of essentially identical operation, and is irrelevant with the specific selection in the group of the assembly of the container of compatibility/quantitatively.In addition, the purpose of the preferred embodiments of the present invention provides a kind of like this system, and this system has a large amount of different coding containers/quantitative assembly and obtains simultaneously the probability of mechanical breakdown is reduced to minimum durable system.
In addition, the purpose of the preferred embodiments of the present invention provides a kind of retention mechanism directly perceived that is used for container is fastened to quantitative assembly.
Summary of the invention
In first aspect, the present invention relates to a kind of medical delivery system, comprising:
Container, it is suitable in the chamber that the piston container and slidably setting limits, holding medicament, and this piston can move along distal direction towards outlet so that reduce the volume of chamber and pass through to export the ejection medicament;
Quantitative assembly, it is adapted to fasten to container, so that allow the piston of the driver of quantitative assembly along the distal direction mobile containers;
Wherein quantitatively assembly defines first clamp device; During container and quantitative assembly fastening; This first clamp device engages with second clamp device of container; Container is through being fastened to quantitative assembly at least one the predetermined motion that limits in first and second clamp devices thus, and this predetermined motion is less than a revolution;
Wherein in container and the quantitative assembly defines first parts; These first parts comprise the rotatable element that limits one or more excrescences and/or breach; During container and quantitative assembly fastening; Said one or more excrescence and/or breach be suitable for being contained in the one or more corresponding breach and/or excrescence of second parts/and one or more corresponding breach and/or excrescence through second parts receive; These second parts are limited in container and the quantitative assembly another, and
Wherein during container and quantitative assembly fastening, this rotatable element is suitable for rotating around the longitudinal axis of first parts and with respect to first parts.
Through changing the position of rotation according to the rotatable element in the different medical induction system of the present invention, can guarantee the container of first medical delivery system encoded makes it can not be secured to the quantitative assembly of second medical delivery system.Similarly, can guarantee the container of second medical delivery system encoded and make it can not be secured to the quantitative assembly of first medical delivery system.Therefore, because only predetermined container can be attached to specific quantitative assembly, so the safety that medical system according to the present invention has improved user.Therefore, this quantitative assembly can appointment uses with the medicament of predetermined kind and/or concentration, and the container that holds the medicament of other concentration or type can not be attached to this quantitative assembly.
Advantage according to system of the present invention is: the position of rotation through changing rotatable element can be encoded to equipment.Because be used to make container, quantitatively the same tool of assembly and rotatable element can produce the different vessels of many different codings and quantitative assembly, so this is favourable from the viewpoint made.
In context of the present invention, term " medical delivery system " should be understood that any system that can use the flowed medicine that contains medicament.The example of medical delivery system is infusion pump application, doser, form of a stroke or a combination of strokes doser, motor doser and such as the automatic injection device of start writing certainly (TM).
The present invention can be applicable to various can be with the administration device of medicament from the container transport of the quantitative assembly that is suitable for being connected to conveying equipment to user.This conveying equipment can comprise the conveying equipment of any percutaneous that is used for medicine, subcutaneous, intravenous, intramuscular or pulmonary administration.
So the place is used, term " medicament " mean comprise any can be with controlled manner through the flowed medicine that contains medicament, such as liquid, solution, gel or fine suspension such as the conveyer device of hollow needle.Typical medicament comprises preparation or the activating agent of pharmaceuticals such as peptide, protein (for example, insulin, insulin analog and C-peptide) and hormone, acquisition biology, the material of preparation, nutrient formulation and other solid (dispensing) or liquid form based on hormone and gene.
The chamber of container can be limited in one or more sidewalls of container and the piston that slidably is provided with.In most of embodiment, at least a portion of container is annular and limits the cylindrical cavity that receives piston.The far-end of container can comprise and be used for the sealing member that penetrated by sleeve pipe, so that allow to be contained in medicament in the chamber through this sleeve pipe ejection.The far-end of container can be suitable for being attached to the telescopic holder of maintenance.As an example, the far-end of container can comprise screw thread, and this screw thread is suitable for cooperating with the respective threaded of holder, so that can holder be screwed on the container.
Outlet of container can be suitable for cooperating with sleeve pipe or pin or needle hub or infusion set or any other circulation conduit or limiting through it, and this circulation conduit is suitable for providing and leads to the fluid passage that is contained in the medicament in the container.
Quantitatively the driver of assembly can comprise the piston rod that is suitable for along the distal direction mobile piston.This piston rod can comprise firmer and be suitable for the element with at least a portion and preferred most of adjacency of the nearly opposed face of piston than piston; Directly engage with piston with piston rod thus and compare, the power that applies to this stiffener through piston rod is applied to the more large tracts of land of the proximal end face of piston.
Quantitatively assembly limits first clamp device, and during container and quantitative assembly fastening, this first clamp device engages with second clamp device of container.In one embodiment, quantitatively the nearly opposed face of first clamp device of assembly engages with the opposed face far away of second clamp device of container.
Through comprising predetermined motion axially parallel and that rotatablely move at least, such as screw, container can be fastened to quantitative assembly.Through parallel axially with rotatablely moving of rotatablely moving and cause less than a revolution, such as less than 120 degree, such as less than 90 degree, such as less than 60 degree.When the opposed face far away of the nearly opposed face of first clamp device and second clamp device forms when engaging, container impels container and quantitative assembly to be pulled to each other with respect to the rotation of quantitative assembly.
In first embodiment, quantitatively first clamp device of assembly defines the groove that is suitable for receiving the protuberance that second clamp device container limits.During container and quantitative assembly fastening, quantitatively the roughly near opposed face of first clamp device of assembly and container roughly far opposed face engage.At least one the shape that should predetermined move through in the composition surface limits.In another embodiment, second clamp device defines a plurality of protuberances, and such as two, three or four, and first clamp device limits and to be suitable for a plurality of corresponding recesses of engaging with protuberance.
In a second embodiment, groove is limited in container, and protuberance is limited quantitative assembly.In the 3rd embodiment, container limits the combination of groove and protuberance, and said groove and protuberance are suitable for engaging with the corresponding protuberance and the groove that are limited quantitative assembly.
In context of the present invention, term " groove " and " protuberance " only are used in combination with first and second clamp devices, and " breach " and " excrescence " only is used in combination with second parts of the engaging of rotatable element/receiving mechanism and stretched-out coding mechanism.Yet " groove " and " breach " will be counted as synonym, and " excrescence " and " protuberance " will be counted as synonym.
In one embodiment, rotatable element limits one or more excrescences (such as two, three, four or five), and each of said excrescence is suitable for engaging with the corresponding/breach that matches/mate of second parts.In a second embodiment, rotatable element limits one or more breach (such as two, three, four or five), and each of said breach is suitable for engaging with the corresponding/excrescence that matches/mate of second parts.In the 3rd embodiment, rotatable element comprises one or more excrescences and one or more breach.In the embodiment of back, the excrescence of rotatable element is suitable for engaging with one or more breach of second parts, and breach is suitable for engaging with one or more excrescences of second parts.
In one embodiment, breach is than excrescence wideer (circumferentially), thereby the permission protuberance moves in breach inside rotatably, when excrescence is contained in the breach, will allow second parts to rotate with respect to rotatable element thus.The longitudinal axis of winding apparatus, the possible relative rotation between second parts and the rotatable element can less than 60 the degree, such as less than 45 the degree, such as less than 30 the degree, such as less than 5 the degree, such as less than 1 the degree.In another embodiment, during container and quantitative assembly fastening, the possible relative rotation between the rotatable element and first parts is the counterrotating 40-100% between second parts and first parts, such as 60-100%, such as 80-100%.
The sidewall of excrescence can be a v shape, and promptly the width of sidewall in axial direction reduces.Similarly, breach can be a v shape.
Excrescence and breach can have essentially identical circumferential width.Alternately, the comparable breach of excrescence is wide slightly, and in excrescence and the breach at least one can be processed by elastomeric material.
In one embodiment, during container and quantitative assembly fastening, the locking rotatable element is with respect to the rotation of second parts, and for example the possible relative rotation between rotatable element and second parts is spent less than 1.
In addition, when container comprised one or more axially extended breach, second clamp device can be axially disposed between at least one the proximal end face of distal most surface (being the bottom surface of breach) and container in one or more breach.
In one embodiment, first and second clamp devices and excrescence and breach are arranged so that first and second clamp devices must engage so that excrescence is contained in the breach at least in part.In other words, when container was fastened to quantitative assembly, if (first or second clamp device) protuberance is not contained in (first or second clamp device) groove at least in part, then excrescence can not be contained in the breach.Therefore, be advanced in the breach and make rotatable element be contained in the groove and can not decode to armarium until protuberance with respect to first parts rotations through at least a portion that makes excrescence, container can be fastened to quantitative assembly thus.
Rotatable element be suitable for around the longitudinal axis of first parts (central shaft) rotation and in certain embodiments the lockable rotatable element with respect to the axially-movable of first parts.
In one embodiment, rotatable element is the rotation and the radial motion of associating with respect to the rotation of first element.In a specific embodiment, when container was fastened to quantitative assembly, rotatable element was along the rectilinear motion of the tangent line that limits circle, and the center of this circle overlaps with the longitudinal axis (central shaft) of equipment.
In one embodiment; Rotatable element is suitable between first position of rotation and second position of rotation, changing with respect to first parts; Thereby before container and quantitative assembly fastening; Rotatable element is positioned in the primary importance, and when container was fastened to quantitative assembly, rotatable element was positioned in the second position.In one embodiment, rotatable element is for example setovered towards primary importance through spring.
In one embodiment, quantitatively assembly limits first parts, therefore comprises rotatable element.In the embodiment of back, rotatable element can be arranged on the outer surface of quantitative assembly.Alternately, rotatable element can be arranged on the inner surface of quantitative assembly.
In alternate embodiments, container limits first parts and comprises rotatable element.And this rotatable element can be arranged on the interior or outer surface of container.
Excrescence and/or breach can extend along the axially basic and/or radial direction of equipment.Rotatable element can be a ring-type element.Rotatable element can be processed by line or sheet metal sheet.This line and sheet metal can be for example crooked through punching apparatus, so that limit excrescence or breach.In alternate embodiments, rotatable element is processed such as polypropylene, Merlon, polyformaldehyde by molded metal and/or plastic material.Alternately, rotatable element can be processed through the 3d printing process.
In one embodiment, ring-type element comprises at least one excrescence and is suitable for radial contraction when each of this at least one excrescence is advanced in the corresponding breach of second parts.When ring-type element shrank, diameter reduced.Therefore, in one embodiment, ring-type element can be before each of this at least one excrescence be advanced in the corresponding breach of second parts and the surface of first parts, and ring-type element can and/or axially keep with respect to the rotation of first parts thus.When one or more protuberances had been advanced in the breach of coupling, ring-type element had shunk and has not therefore kept with respect to first member, because ring-type element is no longer in abutting connection with ring-type element.
For contractive effect is provided, one or more at least one excrescence of ring-type element can be v shapes, and the wideest part of the comparable coupling breach of the wideest part of v shape portion is wideer.Therefore, when v shape excrescence was pushed in the breach, the side of v shape excrescence was suppressed toward each other, and ring-type element shrinks thus.Through providing when container is not fastened to quantitative assembly and the ring-type element of first members abut, can guarantee that ring-type element will not change position of rotation.If when container is not fastened to quantitative assembly, ring-type element can change the position, then can not predetermined container be fastened to quantitative assembly.
Alternately, perhaps as replenishing, ring-type element can comprise at least one excrescence and can be suitable for radial expansion when each of at least one excrescence is advanced in the corresponding breach of second parts.When ring-type element was expanded, the diameter of ring-type element increased.This expansion effect can realize that hereinafter will combine accompanying drawing that it is explained in more detail through the excrescence that stop collar is provided.
In addition; Through the button that on rotatable element, provides at least one radially to extend; Can keep rotatable element with respect to first parts; When the radial contraction of rotatable element or expansion, this button engages or is disengaged with depression in being limited to first parts, thus the rotatable element and the first parts disengagement/locking and permission or prevent that rotatable element from rotating around the central shaft of first parts and with respect to first parts.This depression can be limited on the button that radially extends of two vicinities, and depression is limited between said two buttons.
Alternately, rotatable element can comprise v shape excrescence and annular excrescence, and the reach of rotatable element in the coupling breach causes v shape excrescence to shrink and cause annular excrescence expansion thus, impels thus to be arranged on two button rotation between the excrescence.This can be used for the joint that rotary knob breaks away from depression.
For a kind of system is provided, wherein the position of rotation of rotatable element limits the coding of first parts, and first parts can be suitable for rotatable element is remained in a plurality of precalculated positions.Therefore during making first parts, said first parts can be encoded through selecting rotatable the expectation position of rotation with respect to first parts.This provides following advantage: utilize two identical elements (rotatable element and first parts) can realize a plurality of different coding.
In one embodiment, container comprises a holder and the tube that limits said chamber.Second clamp device can be limited perhaps this holder can be attached to a holder.And breach/excrescence can be limited the tube holder.Tube can be two independent components with the tube holder, and tube can frictionally remain in the holder.In one embodiment, tube is processed by glass, and the tube holder is processed by non-glass materials, is used for the cover glass tube.Tube remains in the holder on-dismountablely, thereby if tube is pulled down from the tube holder, then can have attached again this tube under the situation of instrument with hands.This provides following advantage: when tube becomes sky, can not re-use a holder, the tube that therefore has a wrong medicament can not insert in the holder and use quantitative assembly to distribute.The tube holder can limit integral member with tube, promptly forms an element that does not have seam.This integral member can form the mechanograph of processing by such as Topas (R) or polyacrylic synthetic resin.This mechanograph can be included in the fastening and encoder element that forms during molded.Yet, can use any material that longer-term storage waits to be contained in the specific medication in the container that is suitable for.
As stated, at least a portion of said predetermined motion can be walk abreast axially with rotatablely move.And, in following at least one:
First and second clamp devices, and
The excrescence of each of the rotatable element and second parts and/or breach,
Can be suitable for preventing predetermined motion axially and/or a part that rotatablely moves, thus preventing connecting of container and quantitative assembly, only if:
Each of first and second clamp devices limits predetermined coding geometric figure, and/or
The excrescence of each of the rotatable element and second parts and/or each of breach limit predetermined coding geometric figure, and/or
Rotatable element with respect to first positioning parts in predetermined position of rotation.
In addition, following coding geometric figure:
One or more in first and/or second clamp device, and/or
One or more in excrescence of at least one of the rotatable element and second parts and/or the breach,
Can limit at least one in following: the radial extension of the circumferential scope of first and second clamp devices, the axial range of first and second clamp devices, first and second clamp devices and the circumferential position of first and second clamp devices.
Therefore, will be appreciated that medical delivery system according to the present invention provides a plurality of coding geometric figures, said geometric each can be used for specifying different character.As an example, first and second clamp devices can be used for specifying first predetermined characteristic of medicament, and such as the kind of medicament, and the position of rotation of rotatable element can be used for specifying second predetermined characteristic of medicament, such as the concentration of medicament.Can be through other example of coding geometric figure characteristic specified: male/female medication; Child/adult's medicine; Preventive drug/curative imitate/is imitated medicine slowly soon.
Alternately, the position of rotation of first and second clamp devices and rotatable element can be redundant, thereby if in them breaks down, another will guarantee only predetermined container and quantitatively assembly can be secured to one another.
Therefore, the coding geometric figure owing to two redundancies provides additional level of security.
One embodiment comprises:
Any first container with above-mentioned characteristic and/or element, this first container are adapted to fasten to any the first quantitative assembly with above-mentioned characteristic and/or element; And
Any second container with above-mentioned characteristic and/or element, this second container are adapted to fasten to any the second quantitative assembly with above-mentioned characteristic and/or element; And
At least one item in wherein following:
First clamp device of quantitative assembly,
Second clamp device of container, and
The excrescence of the rotatable element and second parts and/or each of breach
Be suitable for preventing that the first quantitative assembly and second container are secured to one another, and prevent that the second quantitative assembly and first container are secured to one another.
It is in addition, required that be used for first container is connected and separates with the first quantitative assembly and is used for that second container is connected to the predetermined motion of the second quantitative assembly can be basic identical.
In second aspect, the present invention relates to a kind of being adapted at according to the container that uses (being applicable to medical delivery system) in the medical delivery system of first aspect present invention according to first aspect present invention.
Will be appreciated that the invention according to second aspect can comprise any characteristic and/or element according to the invention of first aspect.Especially, the container of second aspect can comprise any characteristic and/or the element according to the container of first aspect present invention.
In the third aspect, the present invention relates to a kind of being adapted at according to the quantitative assembly that uses (being applicable to medical delivery system) in the medical delivery system of first aspect present invention according to first aspect present invention.
Will be appreciated that the invention according to the third aspect can comprise any characteristic and/or element according to the invention of first aspect.Especially, the quantitative assembly of the third aspect can comprise any characteristic and/or the element according to the quantitative assembly of first aspect present invention.
Description of drawings
To be explained in more detail the present invention with reference to accompanying drawing now, wherein:
Fig. 1,3 and 4 discloses the different embodiment according to medical delivery system of the present invention,
Fig. 2 discloses the excrescence of rotatable ring
Fig. 5 and Fig. 6 disclose the longitudinal cross-section that is contained in the rotatable ring in first parts,
Fig. 7-12 discloses isometric view and the cross section of the different embodiment of rotatable ring,
Figure 13-16 discloses the difference configuration of rotatable element, first and second parts,
Figure 17-20 discloses the radial cross-section of the part of the rotatable element and first element, and
Figure 21-29 discloses the different embodiment of rotatable element.
The specific embodiment
Fig. 1,3 and 4 discloses the exploded view of the medical delivery system 100 that comprises container 102, quantitative assembly 104 (for the sake of simplicity, only its part is disclosed) and rotatable element 106.Quantitatively assembly 104 comprises first clamp device 108, and this first fastening dress limits groove, is used to receive the protuberance that is limited second clamp device 110.Through protuberance is advanced in the groove, container 102 can be fastened to quantitative assembly, and the opposed face far away 112 of protuberance (second clamp device 110) engages with the nearly opposed face 114 of groove (first clamp device 108) thus.Through the relative rotation between quantitative assembly 104 and the container 102, two elements are owing to opposed face 112 far away is pulled to each other with near engaging between the opposed face 114.30 degree because the angular range of groove, two elements only can rotate relative to one another are promptly less than a revolution.
In Fig. 1,3 and 4, first parts 116 are limited quantitative assembly 104, and quantitatively assembly comprises rotatable element 106 again.When two elements are assembled into a time-out (shown in Fig. 5 and 6), rotatable element can axially keep with respect to first parts 116 with respect to 116 rotations of first parts simultaneously.Rotatable element 106 defines two excrescences 118, and said excrescence is suitable for being contained in the breach 120 that is defined in the container 102, and this container defines second parts 122.When excrescence 118 is contained in the breach 120, lock the relative rotary motion of second parts 122 and rotatable element 106.
During container and quantitative assembly fastening, following state appears.Container moves axially towards quantitative assembly.Rotate relative to one another with latter two element, begin to engage until first and second clamp devices (protuberance and groove), so excrescence begins to be contained in the breach.Through further relative motion, quantitatively assembly moves towards container, and excrescence 118 further is advanced in the breach 120 thus.Along with breach rotation (because rotation of container), cause rotatable element 106 to be rotated with respect to quantitative assembly.
In order to be easy in breach 120, to receive excrescence 118, the sidewall of excrescence 118 limits inclined surface (as shown in Figure 2), and the little angular error of relative position still makes excrescence 118 can be contained in the breach 120 between excrescence 118 and the breach 120 thus.
Will be appreciated that whether the definite predetermined container 102 of relatively rotation place between the first/the second clamp device and the breach/excrescence can be attached to predetermined quantitative assembly 104.In Fig. 1, excrescence will be contained in the breach through the further axially-movable between quantitative assembly and the container.Yet in Fig. 3, because their different rotary position, breach can not be contained in the excrescence.
When quantitative assembly and rotating component are assembled into a time-out; Rotatable element keeps for quantitative assembly rotation through button 126 transitory phases; This button engages with the corresponding button (not shown) in the quantitative assembly, and rotatable element can remain in the position of scheduled volume thus.Alternately, because the recess 127 (as shown in Figure 4) that engages with the corresponding button of quantitative assembly, rotatable element can temporarily and with respect to quantitative assembly keep.
According to the alternate embodiments (not shown); Rotatable element can be setovered towards fixing position of rotation with respect to first clamp device through spring member; No matter thereby whether rotatable element is affected, rotatable element will realize with appropriate the aligning all between first clamp device automatically.
Except that above-mentioned button 126 or recess 127, this bias unit can be set.
The nearly surface portion of second clamp device 110 can be provided with apart from the proximal end X1 of container 102.In some embodiments of the invention, this distance X 1 is reduced to minimum, the nearly surface portion of perhaps final second clamp device limits the near-end of container.
The axial range that forms the male element of second clamp device 110 is limited parametric t 1.
In certain embodiments, breach 120 will be longer than X1+t1 from the axial length of the near-end of container 102.Usually, notch length will add 50%, add 100%, add 200%, add 300% such as X1+t1 such as X1+t1 such as X1+t1 such as X1+t1 greater than parameter X 1+t1.
Fig. 5 and Fig. 6 disclose a kind of through the rotatable element of button 126 with respect to the axial maintenance of quantitative assembly, and said button engages with the track 128 of quantitative assembly.
For thin and firm rotatable element is provided, rotatable element can be processed by the punch metal sheet, but this punch metal sheet one or many is crooked so that the shape of expectation is provided.Fig. 7-12 discloses the difformity of rotatable element.In Fig. 9 and Figure 10, the sheet metal of excrescence is bent so that increase the radial extension of excrescence.
Figure 13 discloses the radial cross-section through quantitative assembly 104, container 102 and rotatable element 106.Rotatable element 106 is arranged on the outer surface of quantitative assembly 104, and excrescence 118 extends internally from the inner surface radial direction of rotatable element.During towards quantitative assembly axial advancement, excrescence 118 is contained in the breach 120 of container at container.
Figure 14-16 discloses the embodiment of rotatable element, and wherein rotatable element is rotated when container and quantitative assembly are fastening and moved radially, and when container was fastened to quantitative assembly, rotatable element was carried out linear movement thus.
In Figure 17 and Figure 18, quantitatively assembly 104 limits the depression 130 of circumferentially extending, and button 126 is contained in this depression.Therefore, spinner member 106 therein button 126 be arranged on first position of rotation (disclosed among Figure 18) and button wherein in depression 130 first end 132 and be arranged between the second position of rotation (not shown) in 130 relative second end 134 of caving in and change.In alternate embodiments, depression 130 is limited in the rotatable element, and button is limited quantitative assembly.
Figure 19 and Figure 20 disclose the rotatable element 106 that comprises button 126.And quantitatively assembly 104 comprises a plurality of depressions 136 that limited on button (in the accompanying drawings, only disclosing a depression).Depression 136 is along the interval, medial wall of quantitative assembly, and rotatable element can remain on (quantity is corresponding with the quantity of depression 136) in a plurality of different position of rotation thus.
Figure 21-29 discloses the embodiment that limits the rotatable element of v shape excrescence 138 and/or annular excrescence 140.When v shape excrescence 138 was advanced in the breach 120 of container 102, the distance between the wideest part of v shape portion reduced.Therefore, when excrescence was advanced in the breach, the ring-type element that limits two v shape excrescences 138 shrank.This is the situation among Figure 22,23,24,26 and 29.Similarly, during disclosed two annular excrescences, the reach of annular excrescence 140 in breach 120 causes ring-type element to be expanded in being provided with like Figure 25 and 28.If ring-type element comprises a v shape excrescence and an annular excrescence, the then reach of excrescence in breach button 126 rotations that cause radially extending are as disclosed among Figure 27.Ring-type element can integral body be processed, disclosed connecting together among the end of its center line or sheet metal such as Figure 21,24 and 28.Alternately, the flexible feasible end of line or sheet metal is adjacent to each other or is provided with adjacent to each other, as disclosed among Figure 22,23,25,26 and 29.Ring-type element can be respectively processed by one section or two sections lines or sheet metal as disclosed in Figure 22 and 26.

Claims (19)

1. medical delivery system comprises:
Container (102) is suitable in the chamber that the piston said container and slidably setting limits, holding medicament, and said piston can move so that reduce the volume of said chamber and spray said medicament through said outlet along distal direction towards outlet;
Quantitatively assembly (104) is adapted to fasten to said container (102), so that allow the driver of said quantitative assembly to move the said piston of said container (102) along said distal direction;
Wherein said quantitative assembly (104) defines first clamp device (108); During said container (102) and said quantitative assembly (104) fastening; Said first clamp device engages with second clamp device (110) of said container (102); Said thus container (102) is through being fastened to said quantitative assembly (104) at least one the predetermined motion that limits in said first clamp device (108) and said second clamp device (110); At least a portion of wherein said predetermined motion be walk abreast axially with rotatablely move, said predetermined motion is less than a revolution;
One in wherein said container (102) and the said quantitative assembly (104) defines first parts (116); Said first parts comprise the one or more excrescences (118 of qualification; 138; 140) rotatable element (106); During said container (102) and said quantitative assembly (104) fastening, said one or more excrescences are suitable for receiving/being contained in the one or more corresponding breach (120) another second parts (122) that limit in said container (102) and the said quantitative assembly (104), and
Wherein during said container (102) and said quantitative assembly (104) fastening, said rotatable element (106) is suitable for it is characterized in that around the longitudinal axis of said first parts (116) and with respect to said first parts rotation,
Wherein said rotatable element (106) is suitable for being fastened to quantitative assembly (104) before at container (102), remains in the predetermined angular position with respect to said first parts (116);
Said first clamp device (108) and said second clamp device (110), said one or more excrescences (118; 138; 140) and said one or more corresponding breach (120) be arranged such that first clamp device and second clamp device must engage so that excrescence is contained in said one or more corresponding breach at least in part, make excrescence can not be contained in the corresponding breach (120) and engage at least in part until first and second clamp devices.
2. medical delivery system according to claim 1 wherein during said container (102) and said quantitative assembly (104) fastening, locks the rotation of said rotatable element (106) with respect to said second parts (122).
3. medical delivery system according to claim 1 wherein locks the translational motion of said rotatable element (106) with respect to said first parts (116).
4. medical delivery system according to claim 1, wherein said one or more excrescences (118,138,140) extend along the roughly axial and/or radial direction of said rotatable element (106).
5. according to the described medical delivery system of aforementioned claim 1, wherein said rotatable element (106) is a ring-type element.
6. medical delivery system according to claim 5, wherein said ring-type element comprise at least one said excrescence (138) and are suitable for radial contraction when each of said at least one excrescence (138) of said ring-type element is advanced in the corresponding breach (120) of said second parts (122).
7. medical delivery system according to claim 6, said at least one excrescence (138) of wherein said ring-type element is a v shape.
8. medical delivery system according to claim 5, wherein said ring-type element comprise at least one said excrescence (140) and are suitable for being advanced to said second parts (radial expansion in 122 the corresponding breach (120) time in each of said at least one excrescence (140) of said ring-type element.
9. medical delivery system according to claim 8, said at least one excrescence (140) stop collar of wherein said ring-type element.
10. medical delivery system according to claim 6; Wherein said rotatable element (106) comprises at least one button that radially extends (126); When the radial contraction of said rotatable element (106); Said button (126) is disengaged with the depression (136) that is limited in said first parts (116), and said thus rotatable element (106) is thrown off with said first parts (116) and allowed said rotatable element (106) to rotate around the central shaft of said first parts (116) and with respect to said first parts (116).
11. medical delivery system according to claim 8; Wherein said rotatable element (106) comprises at least one button that radially extends (126); When the radial expansion of said rotatable element (106); Said button (126) is disengaged with the depression (136) that is limited in said first parts (116), and said thus rotatable element (106) is thrown off with said first parts (116) and allowed said rotatable element (106) to rotate around the central shaft of said first parts (116) and with respect to said first parts (116).
12. medical delivery system according to claim 1, wherein said rotatable element (106) are suitable for remaining in a plurality of position of rotation with respect to said first parts (116).
13. medical delivery system according to claim 1, wherein said container (102) comprise tube holder that limits said second clamp device (110) and the tube that limits said chamber, and wherein said tube is attached to said tube holder on-dismountablely.
14. medical delivery system according to claim 1, in wherein following at least one:
Said first clamp device (108) and said second clamp device (110), and
The corresponding breach (120) of said excrescence of said rotatable element (106) (118,138,140) and/or said second parts (122),
Be be suitable for preventing said predetermined motion said axially and/or a part that rotatablely moves, thus preventing connecting of said container and said quantitative assembly, only if:
Each of said first clamp device (108) and said second clamp device (110) limit predetermined coding geometric figure and
Each of the corresponding breach (120) of said excrescence of said rotatable element (106) (118,138,140) and/or said second parts (122) limits predetermined coding geometric figure, and/or
Said rotatable element (106) is positioned in the predetermined angular position with respect to said first parts (116).
15. medical delivery system according to claim 14; The coding geometric figure of wherein said first clamp device (108) and said second clamp device (110); And the said excrescence (118 of said rotatable element (106); 138,140) and/or each of the corresponding breach (120) of said second parts (122) limit at least one in following: the circumferential position of the radial extension of the axial range of the circumferential scope of said first clamp device (108) and said second clamp device (110), said first clamp device (108) and said second clamp device (110), said first clamp device (108) and said second clamp device (110) and said first clamp device (108) and said second clamp device (110).
16. a medical delivery system comprises:
A) first container (102) and b) second container (102); Each cell therefor is suitable in the chamber that the piston corresponding container and slidably setting limits, holding medicament, and said piston can move so that reduce the volume of said chamber and spray said medicament through said outlet along distal direction towards outlet;
C) the first quantitative assembly (104), it is adapted to fasten to said first container (102), so that allow the driver of the said first quantitative assembly (104) to move the said piston of said first container (102) along said distal direction;
The wherein said first quantitative assembly (104) defines first clamp device (108); During said first container (102) and the said first quantitative assembly (104) fastening; Said first clamp device engages with second clamp device (110) of said first container, and said thus first container (102) is fastened to the said first quantitative assembly (104) through being limited less than a rotating predetermined motion in said first clamp device (108) and said second clamp device (110) at least one;
Wherein said first container (104) defines first parts (116); Said first parts comprise the one or more excrescences (118 of qualification; 138; 140) first rotatable element (106), during said first container (102) and the said first quantitative assembly (104) fastening, said one or more excrescences (118; 138; 140) be suitable for receiving/being contained in the one or more corresponding breach (120) of second parts (122) that limited the said first quantitative assembly (104), wherein during said first container (102) and the said first quantitative assembly (104) fastening, said first rotatable element (106) is suitable for rotating around the longitudinal axis of said first parts (116) and with respect to said first parts;
D) the second quantitative assembly (104) is adapted to fasten to said second container (102), so that allow the driver of the said second quantitative assembly (104) to move the said piston of said second container (102) along said distal direction;
The wherein said second quantitative assembly (104) defines the 3rd clamp device (108); During said second container (102) and the said second quantitative assembly (104) fastening; Said the 3rd clamp device engages with the 4th clamp device (110) of said second container (102), and said thus second container (102) is fastened to the said second quantitative assembly (104) through being limited less than a rotating predetermined motion in said the 3rd clamp device (108) and said the 4th clamp device (110) at least one;
Wherein said second container defines the 3rd parts (116); Said the 3rd parts comprise the one or more excrescences (118 of qualification; 138; 140) second rotatable element (106), during said second container (102) and the said second quantitative assembly (104) fastening, said one or more excrescences (118; 138; 140) be suitable for receiving/being contained in the one or more corresponding breach (120) of the 4th parts (122) that limited the said second quantitative assembly (104), wherein during said second container (102) and the said second quantitative assembly (104) fastening, said second rotatable element (106) is suitable for rotating around the longitudinal axis of said first parts (116) and with respect to said first parts; At least one item in wherein following:
Said the 3rd clamp device (108) of said first clamp device (108) of the said first quantitative assembly (104) and the said second quantitative assembly (104),
Said second clamp device (110) of said first container (102) and said the 4th clamp device (110) of said second container (102), and
Each of the said excrescence of said first rotatable element (106) and second rotatable element (106) is or/and each of the said breach of said second parts (122) and said the 4th parts (122);
Be suitable for preventing that the said first quantitative assembly (104) and said second container (102) are secured to one another, and prevent that the said second quantitative assembly (104) and said first container (102) are secured to one another.
17. medical delivery system according to claim 16, the wherein required said predetermined motion that is used for said first container (102) is connected and separates and be used for said second container (102) is connected to the said first quantitative assembly (104) the said second quantitative assembly (104) is basic identical.
18. one kind is adapted at the container (102) that uses according in each the medical delivery system among the claim 1-17.
19. one kind is adapted at the quantitative assembly (104) that uses according in each the medical delivery system among the claim 1-17.
CN2007800266605A 2006-07-15 2007-07-15 A medical delivery system with flexible blocking element Expired - Fee Related CN101489607B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP06014769 2006-07-15
EP06014769.1 2006-07-15
EP06118846 2006-08-14
EP06118846.2 2006-08-14
PCT/EP2007/057283 WO2008009646A1 (en) 2006-07-15 2007-07-15 A medical delivery system with a rotatable coding element

Publications (2)

Publication Number Publication Date
CN101489607A CN101489607A (en) 2009-07-22
CN101489607B true CN101489607B (en) 2012-09-05

Family

ID=36922212

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2007800328673A Expired - Fee Related CN101511411B (en) 2006-07-15 2007-07-15 A medical delivery system with flexible blocking element
CN2007800266605A Expired - Fee Related CN101489607B (en) 2006-07-15 2007-07-15 A medical delivery system with flexible blocking element

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2007800328673A Expired - Fee Related CN101511411B (en) 2006-07-15 2007-07-15 A medical delivery system with flexible blocking element

Country Status (1)

Country Link
CN (2) CN101511411B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168203B2 (en) 2010-05-21 2015-10-27 Carmel Pharma Ab Connectors for fluid containers

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102028619B (en) * 2009-09-29 2015-08-26 吴振文 Can the container of accommodating different injection medicament
CA2795484A1 (en) * 2010-04-09 2011-10-13 Sanofi-Aventis Deutschland Gmbh Coded drug reservoir connection element with bendable locking elements
CN102946929B (en) * 2010-04-23 2016-02-24 赛诺菲-安万特德国有限公司 There is cartridge module and the delivery device of shared retention mechanism
CA2799953C (en) * 2010-05-21 2015-07-07 Carmel Pharma Ab Connector, fluid container
US10188801B2 (en) 2010-08-13 2019-01-29 Sanofi-Aventis Deutschland Gmbh Mechanism for preventing selection of a dose
KR101019085B1 (en) * 2010-10-19 2011-03-07 (주)패스텍 Filter container for extracting cells
US20130289488A1 (en) * 2010-12-27 2013-10-31 Sanofi-Aventis Deutschland Gmbh Dedicated Cartridge and Holder
AR086256A1 (en) * 2011-05-06 2013-11-27 Sanofi Aventis Deutschland DRIVE SET FOR A DRUG ADMINISTRATION DEVICE AND CORRESPONDING DRUG ADMINISTRATION DEVICE
TWI539981B (en) * 2011-05-06 2016-07-01 賽諾菲阿凡提斯德意志有限公司 Assembly for a drug delivery device and drug delivery device
WO2014111338A1 (en) 2013-01-15 2014-07-24 Sanofi-Aventis Deutschland Gmbh Pen type drug injection device with low friction dose encoder mechanism on thread

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5611783A (en) * 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
EP0774270A1 (en) * 1995-11-16 1997-05-21 Diesse di Soster Carmen & C. S.n.C. Blood or hemo-derivatives transfusion device
US5957896A (en) * 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
US6648859B2 (en) * 1997-09-29 2003-11-18 Becton Dickinson And Company Disposable, pre-filled drug cartridge

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0600138B1 (en) * 1992-11-30 1997-04-16 Wilhelm A. Keller Cartridge with at least one storage container and with mixer
EP0730913B1 (en) * 1995-03-07 2001-10-31 Wilhelm A. Keller Bayonet fastening device for the attachment of an accessory to a multiple component cartridge or dispensing device
DE19900792C1 (en) * 1999-01-12 2000-06-15 Disetronic Licensing Ag Injection unit forming part of e.g. pen-type self-injection syringe has continuous dosing stop in spiral form with constant pitch ensuring close fine control and accuracy in use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5611783A (en) * 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
EP0774270A1 (en) * 1995-11-16 1997-05-21 Diesse di Soster Carmen & C. S.n.C. Blood or hemo-derivatives transfusion device
US5957896A (en) * 1997-08-11 1999-09-28 Becton, Dickinson And Company Medication delivery pen
US6648859B2 (en) * 1997-09-29 2003-11-18 Becton Dickinson And Company Disposable, pre-filled drug cartridge

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168203B2 (en) 2010-05-21 2015-10-27 Carmel Pharma Ab Connectors for fluid containers

Also Published As

Publication number Publication date
CN101511411B (en) 2012-02-15
CN101511411A (en) 2009-08-19
CN101489607A (en) 2009-07-22

Similar Documents

Publication Publication Date Title
CN101489607B (en) A medical delivery system with flexible blocking element
US9050397B2 (en) Medical delivery system with a rotatable coding element
CN101600468B (en) A syringe device
CN101541364B (en) Medical delivery system comprising locking ring with l-shaped grooves
EP2037987B1 (en) A medical delivery system comprising a coding mechanism
EP2091598B1 (en) A medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US8613731B2 (en) Medical delivery system with asymmetrical coding means
US20100042054A1 (en) Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container
CN101489608B (en) Medical delivery system with asymmetrical coding means

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120905

Termination date: 20200715

CF01 Termination of patent right due to non-payment of annual fee