CN101495062B - Apparatus for light-based hair removal using incoherent light pulses - Google Patents
Apparatus for light-based hair removal using incoherent light pulses Download PDFInfo
- Publication number
- CN101495062B CN101495062B CN2007800055356A CN200780005535A CN101495062B CN 101495062 B CN101495062 B CN 101495062B CN 2007800055356 A CN2007800055356 A CN 2007800055356A CN 200780005535 A CN200780005535 A CN 200780005535A CN 101495062 B CN101495062 B CN 101495062B
- Authority
- CN
- China
- Prior art keywords
- pulse
- light
- pulses
- average
- incoherent light
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
Methods and apparatus for damaging hair follicles using a series of rapidly-delivered low-fluence pulses of incoherent light are disclosed herein. In some embodiments, the pulses of coherent or incoherent light have a wavelength or wavelengths primarily in the range between 750 nm and 1500 nm. In some embodiments, applied electromagnetic radiation comprising the rapidly-delivered low-fluence pulses is effective for concomitantly heating both the sub-dermal layer (i.e. the dermis) of the tissue and the hair follicles. In some embodiments, the thermal damaging of the hair follicles is useful for facilitating hair-removal.
Description
Technical field
The method and apparatus that for example the present invention relates to use the incoherent light from flash lamp to lose hair or feathers.
Background technology
The disclosure relates to uses the incoherent light that comprises a plurality of incoherent light pulses to destroy the hair follicle improved method and apparatus of (for example, being used for depilation).
Selective light pyrolysis effect is a kind of surgical method (" Selective Photothermolysis:Precise Microsurgery by Selective Absorption of Pulsed Radiation " that is proposed in nineteen eighty-three by Anderson and Parrish; Science; Vol.220; Pp.524-527), its be used to destroy on the skin or skin near some ill or ugly tissue, and to around health tissues have minimum injury.Want destructive tissue to be characterised in that to compare the light absorption of some wavelength of electromagnetic radiation obviously more with surrounding tissue.This method comprises that use can be by the pulsed electromagnetic radiation irradiation target and the surrounding tissue of target priority absorption.Owing to compare with surrounding tissue, target is a lot of by force to the absorption of incident radiation, and the heating of surrounding tissue can be ignored usually.
In in the past 10 years, the equipment based on laser and flash of light that a lot of principles according to selective light pyrolysis effect remove unwanted hair is introduced into market, and up to the present, this technology is widely used in clinical.In therapeutic process, with the skin in light beam irradiation treatment zone, contain melanic hair follicle and absorb the electromagnetic radiation of carrying, thereby cause temperature to rise and the destruction of hair follicle.
Unfortunately; According to this therapeutic process, the light that is transported to area for treatment heated concomitantly the patient contain nerve (nerve containing) be rich in melanic epidermis, dimension; Under a lot of clinical settings, be considered to the process of a misery based on the alopecia of light.
Improved hair treatment method and need for equipment are extensively approved; And this method and apparatus has the advantage of height; Said hair treatment method is heated to sufficiently high temperature with device with hair follicle and is convenient to depilation to destroy hair follicle and to make, carries the heat energy of minimum to containing neural epidermis simultaneously.This possibly be useful for the long-range market demand that satisfies comfortable depilation.
The patent document that following discloses are delivered provides the background technology that possibly be correlated with, and its each full content is here through with reference to incorporating into: U. S. application 2005/0215988; US 6,485, and 484; WO 2005/079687; US 6,544, and 259; US 5,632, and 741; US 5,752, and 948; US 6,214, and 034; US 6,273, and 884; US 5,683, and 380; US 6,514, and 243; U. S. application 2005/0143792; US5,735,884; US 5,595, and 568; U. S. application 2002/0019624; U. S. application 2005/0143792.
Summary of the invention
Embodiment of the present invention; Partly; Based on following surprising discovery: promptly carry a series of low fluences (low fluence) incoherent light pulses (for example from flash lamp) fast, just might heat epidermis simultaneously with minimizing from the area for treatment depilation through area for treatment to skin.
A kind of method of in containing the tissue regions of a plurality of hair follicles, destroying hair follicle is disclosed now first; This method comprises: a) this tissue regions is applied the electromagnetic energy that comprises a plurality of incoherent light pulses, wherein: i) each said incoherent light pulses mainly is included at least 750 minimum wavelength value and the wavelength in the scope between 1500 the maxima of waves long value at the most; Ii) the average pulse fluence of said a plurality of pulses is at least the minimum fluence value of 0.5J/cm^2 at least, is at most the maximum fluence value of 10J/cm^2 at the most; Iii) the average repetitive rate of said a plurality of pulses is at least the repetition values of 1.5HZ at least; Iv) the average pulse persistent period of said light pulse is at least 1 millisecond.
According to some embodiments, the minimum wavelength value is at least 780nm.
According to some embodiments, the maxima of waves long value is at most 1200nm.
According to some embodiments, the maxima of waves long value is at most 1000nm.
According to some embodiments, at least 75% incoherent light wavelength is in this scope in this incoherent light pulses.
According to some embodiments, at least 95% incoherent light wavelength is in this scope in this incoherent light pulses.
In exemplary embodiment, this can be through using low pass filter filtering, and for example, broadband light realizes.Therefore in some embodiments, this incoherent light source comprises wave filter.
According to some embodiments, the average pulse persistent period of this pulse is at least 2 milliseconds.
According to some embodiments, the average pulse persistent period of this pulse is at least 4 milliseconds.
According to some embodiments, the average pulse persistent period of this pulse is at most 10 milliseconds.
According to some embodiments, the average pulse persistent period of this pulse is at most 6 milliseconds.
According to some embodiments, this repetition values is 2HZ at least, perhaps 3HZ at least, perhaps 5HZ at least, perhaps 10HZ at least.
According to some embodiments, the long-pending of this average pulse persistent period (promptly being unit with the second) and this repetition values (being unit with second-1 promptly) is at least 0.01, perhaps at least 0.015.
According to some embodiments, the long-pending of this average pulse persistent period (promptly being unit with the second) and this repetition values (being unit with second-1 promptly) is at the most 0.04, perhaps at the most 0.03, perhaps at the most 0.025.
According to some embodiments, apply at least 3 pulses (perhaps at least 5 pulses, perhaps at least 15 pulses, perhaps at least 30 pulses) with this average repetitive rate.
According to some embodiments, every square centimeter average power density of the electromagnetic energy that is applied is at least at least 5 watts/centimetres
2The minimum average B configuration power density values.
According to some embodiments, this minimum average B configuration power density values is at least 10 watts/centimetre
2
According to some embodiments, in that average repetitive rate applies in the time period of 3 pulses at least with this, this average power density is at least the minimum average B configuration power density values.
According to some embodiments, in that average repetitive rate applies in the time period of 5 pulses at least with this, this average power density is at least the minimum average B configuration power density values.
According to some embodiments, in that average repetitive rate applies in the time period of 15 pulses at least with this, this average power density is at least the minimum power density value.
According to some embodiments, in that average repetitive rate applies in the time period of 30 pulses at least with this, this average power density is at least the minimum power density value.
According to some embodiments, this average power density is at least the minimum power density value at least 1 second time period.
According to some embodiments, this average power density is at least the minimum power density value at least 2 seconds time period.
According to some embodiments, this average power density is at least the minimum power density value at least 3 seconds time period.
According to some embodiments, the average power density of the electromagnetic energy that is applied is at most 40 watts/centimetre at the most
2The maximum power density value.
According to some embodiments, this maximum power density value is at most 25 watts/centimetre
2
According to some embodiments, this average power density is at most the maximum power density value at least 1 second time period.
According to some embodiments, this average power density is at most the maximum power density value at least 2 seconds time period.
According to some embodiments, this average power density is at most the maximum power density value at least 3 seconds time period.
According to some embodiments, the mean power of the electromagnetic energy that is applied is at least at least 50 watts minimum average B configuration performance number.
According to some embodiments, this minimum average B configuration performance number is at least 75 watts.
According to some embodiments, in that average repetitive rate applies in the time period of 3 pulses at least with this, this mean power is at least the minimum average B configuration performance number.
According to some embodiments, in that average repetitive rate applies in the time period of 5 pulses at least with this, this mean power is at least the minimum average B configuration performance number.
According to some embodiments, in that average repetitive rate applies in the time period of 15 pulses at least with this, this mean power is at least minimal power values.
According to some embodiments, in that average repetitive rate applies in the time period of 30 pulses at least with this, this mean power is at least minimal power values.
According to some embodiments, this mean power is at least minimal power values at least 1 second time period.
According to some embodiments, this mean power is at least minimal power values at least 2 seconds time period.
According to some embodiments, this mean power is at least minimal power values at least 3 seconds time period.
According to some embodiments, the mean power of the electromagnetic energy that is applied is at most 250 watts maximum power value at the most.
According to some embodiments, this maximum power density value is at most 150 watts.
According to some embodiments, this mean power is at most maximum power value at least 1 second time period.
According to some embodiments, this mean power is at most maximum power value at least 2 seconds time period.
This mean power is at most maximum power value at least 3 seconds time period.
According to some embodiments, the average repetitive rate of these a plurality of pulses is at most the repetition values of 25HZ at the most.
According to some embodiments, the average repetitive rate of these a plurality of pulses is at most the repetition values of 15HZ at the most.
According to some embodiments, maximum mean fluence value is at most 8J/cm^2.
According to some embodiments, this maximum mean fluence value is at most 6J/cm^2.
According to some embodiments, the pulse fluence standard deviation of these a plurality of pulses is at most 0.5 standard deviation ratio at the most with the ratio of the average pulse fluence of these a plurality of pulses.
According to some embodiments, this standard deviation ratio is at most 0.2.
According to some embodiments, the electromagnetic radiation that is applied is heated to the hypodermic layer of skin area the minimum temperature of minimum 42 degree effectively.
According to some embodiments, this minimum temperature is at least 45 degree.
According to some embodiments, the electromagnetic radiation that is applied is heated to the hypodermic layer of skin area the maximum temperature of maximum 50 degree effectively.
According to some embodiments, the peak power of the electromagnetic energy that is applied is at most 10,000 watts maximum peak power value at the most.
According to some embodiments, this maximum peak power value is at most 6,000 watts.
According to some embodiments, the peak power density of the electromagnetic energy that is applied is at most 1,500 watt/centimetre at the most
2The maximum peak power density value.
According to some embodiments, this peak-peak density performance number is at most 1,250 watt.
According to some embodiments, the speckle area of this incoherent light at 2cm^2 between the 10cm^2.
According to some embodiments, the speckle area of this incoherent light at 3cm^2 between the 7cm^2.
According to some embodiments, the average pulse fluence of these a plurality of pulses is at most the maximum ratio of 3 (J*s)/cm^2 at the most with the ratio of average repetitive rate.
According to some embodiments, this maximum ratio is at most 2.5 (J*s)/cm^2.
According to some embodiments, this maximum ratio is at most 2 (J*s)/cm^2.
According to some embodiments, this maximum ratio is at most 1.5 (J*s)/cm^2.
According to some embodiments, this maximum ratio is at most 1 (J*s)/cm^2.
According to some embodiments, this average pulse fluence is at most the maximum ratio of 1.5J/ (cm^2*ms) at the most with the ratio of average pulse persistent period.
According to some embodiments, this maximum ratio is at most 1J/ (cm^2*ms).
According to some embodiments, this maximum ratio is at most 0.75J/ (cm^2*ms).
According to some embodiments, this tissue regions has 2cm^2 and the size of 1000cm^2 at least at the most.
According to some embodiments, the step that applies coherent optical pulse comprises uses flash lamp to generate coherent optical pulse.
According to some embodiments, carry electromagnetic radiation from the device that applies that is positioned at this tissue regions surface, make this apply between lower surface and this tissue regions surface of device and have the gap.
According to some embodiments, carry electromagnetic radiation from applying device, the said device that applies comprises: i) transparent feed surface; And ii) shell (spacer housing) at interval, this applies device and is configured so that this transparent feed surface is in this tissue regions surface after will applying device and joining this tissue regions surface to.
According to some embodiments; The step that applies the electromagnetic energy that comprises a plurality of pulses applies the device speed device that applies that the mobile at least minimum of 2cm at least applies the device distance in this tissue regions surface through use with one and carries out; This applies device speed and is at least at least that the minimum of 1cm/sec applies the device rate value, and is at most at the most that the maximum of 20cm/sec applies the device rate value.
According to some embodiments, this minimum applies the device distance and is at least 3cm.
According to some embodiments, this minimum applies device speed and is at least 2cm/sec.
According to some embodiments, this minimum applies device speed and is at least 3.5cm/sec.
According to some embodiments, this maximum applies device speed and is at most 10cm/sec.
According to some embodiments, this maximum applies device speed and is at most 7cm/sec.
According to some embodiments, this method also comprises: at least a portion of b) cooling off this tissue.
According to some embodiments, the step that applies this electromagnetic energy is not carrying out carrying out under the refrigerative situation to this tissue regions.
According to some embodiments, this applies step and comprises: i) set up the energy phase (energy phase), the electromagnetic energy that is applied of a plurality of pulses that apply with average repetitive rate is stood to comprise in the given area that wherein has the 2cm^2 surface area; And ii) at once resting stage is set up in the given area after the phase at energy; It had 2 seconds and was at most at the most the persistent period of 60 minutes persistent period maximum stationary phase at least; Make in resting stage, be applied to tissue regions have at least 750nm and at the most the mean power of the electromagnetic energy that applies of 1500nm wavelength be at most 30 watts; Iii) after resting stage at once to given tissue regions repeating step (a) and (b) at least M time, M is an integer, its value is at least 1.
According to some embodiments, this persistent period resting stage was at least 10 seconds.
According to some embodiments, this persistent period resting stage was at least 30 seconds.
According to some embodiments, this persistent period resting stage was at least 90 seconds.
According to some embodiments, this persistent period resting stage is at most 10 minutes.
According to some embodiments, this persistent period resting stage is at most 5 minutes.
According to some embodiments, M is at least 2.
According to some embodiments, M is at least 3.
According to some embodiments, each the energy phase in a plurality of resting stages, be at most in time period of 20 minutes, the accumulative total of the electromagnetic energy that each energy phase is applied applies energy density and is 20J/cm^2,200J/cm^2 at the most at least.
According to some embodiments, will comprise that the electromagnetic energy of pulse is applied on the light skin.
According to some embodiments, the electromagnetic radiation that will comprise pulse be applied to comprise the low hair of melanin content tissue to destroy the low hair of this melanin content.
According to some embodiments, will comprise that the electromagnetic radiation of pulse is applied on the 1-3 type Fitzpatrick skin to destroy and the relevant hair of 1-3 type Fitzpatrick skin.
According to some embodiments, will comprise that the electromagnetic radiation of pulse is applied on the 4-6 type Fitzpatrick skin to destroy and the relevant hair of 4-6 type Fitzpatrick skin.
According to some embodiments, this electromagnetic radiation is applied to tissue to destroy the melanin content low hair relevant with this tissue.
Notice, disclosed herein is a lot of therapeutic schemes.It should be understood that any equipment or the device that are configured to carry out any this disclosed therapeutic scheme are included within the scope of the present invention.
Therefore; In an example; A kind of device that is used in containing the tissue regions of a plurality of hair follicles, destroying hair follicle is disclosed now first; This device comprises: a) incoherent light source, be used to generate the incoherent light that comprises a plurality of incoherent light pulses, and each said incoherent light pulses mainly is included in the minimum wavelength value of 750nm at least and the wavelength in the scope between the maxima of waves long value of 1500nm at the most; And b) controller; Be used for controlling at least in part the pulse characteristics of said light pulse; Said light source and said controller are arranged such that: i) the average pulse fluence of said a plurality of pulses is at least the minimum fluence value of 0.5J/cm^2 at least; And be at most at the most the maximum fluence value of 10J/cm^2 (perhaps, for example, 8J/cm^2 or 6J/cm^2); Ii) the average repetitive rate of said a plurality of pulses is at least at least the repetition values of 1.5HZ (perhaps, for example, 3HZ or 5HZ or 7HZ); Iii) the average pulse persistent period of said light pulse is at least 1 millisecond.
These and further embodiment will be from subsequently detailed description and instance obviously.
Description of drawings
Figure 1A-1C provides the block diagram that destroys the exemplary device of hair follicle according to certain embodiments of the present invention with electromagnetic radiation;
Fig. 2 provides the block diagram of exemplary control unit;
Fig. 3 provides the block diagram of exemplary pulse light source;
Fig. 4 A provides the block diagram of exemplary area for treatment;
Fig. 4 B provides the block diagram of the exemplary technique that is used for treating each seed region of area for treatment;
Fig. 5 provides the motion pattern of the example procedure that is used for treated tissue (for example skin) given position or zone.
Although invention has been described for the instance here through several kinds of embodiments and sketch map, those skilled in the art will appreciate that to the invention is not restricted to described embodiment and accompanying drawing.Should be understood that this accompanying drawing and detailed description are not intended to the present invention is restricted to disclosed ad hoc fashion, on the contrary, the present invention will comprise that all fall into the interior modification of spirit and scope of the invention, are equal to and change.Run through the employed speech of the application " possibility " or " can " as permission property meaning (that is, expression " possible "), rather than mandatory meaning (that is, representing " necessary ").
The specific embodiment
Now will present invention is described according to concrete instance embodiment.It being understood that and the invention is not restricted to disclosed instance embodiment.It is to be further understood that as in the accompanying claims any specific one desired, be not each characteristic of being used for the disclosure apparatus and method of heat damage hair follicle all be realize essential to the invention.The various elements of description equipment and characteristic can realize to make the present invention fully.It is to be further understood that and run through the disclosure, showing or describing under the situation of process or method, can or side by side carry out the step of this method, depend on the step that another is carried out earlier only if from context, can obviously find out a step with any order.
Introduce and theoretical discussion
Embodiment of the present invention; Partly; Based on following surprising discovery: promptly, just might in the hair follicle that effectively destroys in the area for treatment, heat epidermis through carry a series of low fluence incoherent light pulses incoherent light pulses of flash lamp (for example from) fast to the area for treatment of skin with minimizing.Notice that the foreshortened follicle destroy technology can be used for losing hair or feathers from skin treatment area safely.
Especially; And do not hope by theory; Notice; Although each independently incoherent light pulses can be relatively ' low fluence ' light pulse, this a plurality of low fluence pulse of carrying fast all possibly provide enough mean power to be convenient to lose hair or feathers necessary degree so that the hypodermic layer of heat conduction or corium are heated to sufficiently high temperature (for example, at least 42 degree or at least 45 degree) so that hair follicle is corrupted in time enough.Through the pulse (promptly with lower repetitive rate conveying) that low fluence pulse of quick conveying rather than higher fluence are provided, just might be with less painful and/or less required cooling and/or so that the scheme of safety and/or the epidermis of less following heating to contain nerve destroy hair follicle.
Do not hope once more by theory; Because corium is the good conductor of heat; When with ' high-repetition-rate ' apace during transport pulse; The temperature that requires (i) hair follicle does not drop under the temperature (being the dermal temperature that is heated) of the corium that is heated being long enough to destroy in the time period of hair follicle, and (ii) the heat damage of hair follicle is used to be convenient to depilation.
Notice that it possibly be useful using the interior light of some wave-length coverage to heat and destroy hair follicle (promptly with a kind of mode useful to hair).Therefore; In some embodiments; The light radiation of the low fluence pulse of carrying fast comprises wavelength light in " optical window " of (or between 780nm and 1000nm) between 750nm and 1500nm, and it is penetrated into epidermis below and hypodermis layer (the being corium) conveying capacity below epidermis.
Do not hope to be noticed that the light in this ' optical window ' possibly be not so good as the heating of epidermis by theory, for example, the light between 650nm and 700nm in scope or other scopes.Therefore, might utilize chromophore in the surrounding tissue as ' reservoir ' with effective heating with destroy hair follicle, rather than rely on selective light pyrolysis effect specially and heat and be rich in melanic hair follicle.
In some embodiments, when applying a plurality of incoherent light pulses (for example), one or more in the following characteristic can be provided through the broadband light of filtering:
I) ' low ' mean fluence of a plurality of incoherent light pulses of carrying fast (promptly to each pulse average), it is each pulse 10J/cm^2 at the most, perhaps each pulse 8J/cm^2 at the most, perhaps each pulse 6J/cm^2 at the most;
Ii) ' high-repetition-rate '-for example, 1.5HZ at least, perhaps 2HZ at least, perhaps 2.5HZ at least, perhaps 5HZ at least, perhaps 7.5HZ at least.In different instances, lower fluence can combine with higher repetitive rate;
Iii) ' high-average power ' (promptly relevant with low fluence) kept this high-average power (for example, be heated at least 42 or 45 degree and continue at least 0.5 second, or at least 1 second, or at least 2 seconds, or at least 2.5 seconds) necessary preset time at the heat damage hair follicle in the section.In exemplary embodiment, should ' height ' mean power can be at least 35 watts, or at least 50 watts, or at least 75 watts.Concrete mean power can depend on the physiologic factor such as the hair and/or the colour of skin;
Iv) ' weak point ' pulse width or pulse duration one for example are less than 10 milliseconds but be longer than 0.5 millisecond or be longer than 1 millisecond.In some embodiments, the pulse width of each pulse or persistent period are between 2 to 7 milliseconds.
Notice that instruction of the present invention can be used for any zone depilation from health, includes but not limited to back, face, head, eyebrow, eyelashes, chest, abdominal part, genital area, lower limb and axillary fossa.
And; Notice that given area or subregion or the area that light (for example one or more light pulse) was applied or be delivered to tissue (for example skin) relates to light (for example one or more light pulse) is applied or be delivered to any one or a plurality of position in this tissue regions or the subregion.
Light radiation and pulse character
Various embodiment of the present invention provides the combination in any of following marked feature.It is understandable that, be not that in following these characteristics each all must be included in each embodiment.
are wavelength characteristic a).The inventor discloses a kind of therapy and equipment, and it carries the light radiation of the light radiation that comprises " penetrating darker " to patient's skin, and it passes and is rich in melanic epidermis and is absorbed by subcutaneous tissue (being corium).In some embodiments, this penetrates darker light radiation and comprises the light of wavelength between minimum wavelength value (for example, 750nm, for example 780nm or 800nm) and maxima of waves long value (for example, 950nm, or 980nm, or 1000nm, or 1200nm, or 1500nm).Do not hope by theory; Disclosing can be with in " optical window ", selecting wavelength to be used to provide unlikely heating to contain the therapeutic scheme (or therapeutic equipment) of neural epidermis; Therefore got rid of the needs of (but not necessarily eliminating) loaded down with trivial details cooling (apply concomitantly, or use " pre-cooling scheme " to apply) and/or therefore a kind of safer therapeutic scheme is provided.
In exemplary embodiment, this light through a plurality of frequencies are provided (for example, from IPL equipment and by the light of band-pass filter); Make the wavelength of the light radiation that most of (or more) applied by minimum wavelength value (750nm for example; For example 780nm or 800nm) and maxima of waves long value (for example 950nm, or 980nm, or 1000nm; Or 1200nm, or 1500nm) provides in the setted wavelength scope of definition.
In some embodiments, the incoherent light that is applied and/or each pulse ' mainly ' wherein comprise that wavelength by the incoherent light of the wavelength in the scope of minimum wavelength value and maximum wavelength value defined-promptly at least 70% or each pulse wherein is in this scope.
In some embodiments, the wavelength of at least 75% incoherent light or each pulse wherein is in this scope.
In some embodiments, the wavelength of at least 90% incoherent light or each pulse wherein is in this scope.
In some embodiments, the wavelength of at least 95% incoherent light or each pulse wherein is in this scope.
b) fluence characteristic.The inventor discloses, and might lose hair or feathers through patient skin being applied low fluence incoherent light pulses.
In exemplary embodiment, the fluence that should ' hang down the fluence pulse ' is less than 10J/cm^2 for each pulse, or is less than 8J/cm^2, or is less than 6J/cm^2.
It is understandable that, when applying a plurality of series of pulses, be not that each each pulse all need have identical accurate fluence, and the fluence between pulse can have some variations.
In some embodiments, yet each pulse of the given a plurality of pulses in the scope of disclosed being used for ' average pulse fluence '-for example, the fluence of each pulse is less than 10J/cm^2, or 8J/cm^2, etc.
Notice that the concrete fluence that is provided (and such as other characteristics such as pulse width, repetitive rate and power) possibly depend on a lot of physiologic factors, includes but not limited to the colour of skin and hair color.For example, for the hair (the lower hair of " melanism " degree) of lighter color, possibly need to select bigger fluence.Similarly, for the darker skin of color, possibly need to select less fluence.
Notice that these low fluence pulses are shockingly effective for depilation.
c) repetitive rate characteristic.The inventor discloses depilation scheme and equipment first, and wherein light is applied on the skin with certain " height " repetitive rate.
As used herein, the umber of pulse that the speed of each pulse that ' high-repetition-rate ' refers to carry on the section in preset time (be the umber of pulse of per second, or HZ)-institute carries or provides is divided by the length of ' given ' time period.In different embodiment, this, section can be preset time, for example, and at least 0.5 second, at least 1 second, at least 1.5 seconds, at least 2 seconds, at least 3 seconds, at least 5 seconds or at least 10 seconds.
In exemplary embodiment, should be at least 1.5 pulse/sec by ' fast ' repetitive rate, and/or at least 2.5 pulse/sec, and/or at least 3 pulse/sec, and/or at least 7.5 pulse/sec, and/or at least 5 pulse/sec.
In some embodiments, maximum repetition rate is 20 or 15 or 12.5 or 10 pulse/sec.In some embodiments, when repetitive rate increased, selected fluence was lower.
d) pulse duration/the pulse width characteristic.In exemplary embodiment, the pulse width of each incoherent light pulses or persistent period do on an average, for example, is less than 10 milliseconds but be longer than 0.5 millisecond or be longer than 1 millisecond.In some embodiments, the pulse width of each pulse or persistent period, on an average, between 2 to 7 milliseconds.
Notice once more, the concrete fluence that is provided, and concrete pulse duration or pulse width possibly depend on a lot of physiologic factors, includes but not limited to the colour of skin and hair color.For example, for the hair (the lower hair of " melanism " degree) of lighter color, possibly need select to have big fluence than long pulse.Similarly, for the darker skin of color, possibly need select to have less fluence than short pulse.
e) relation between fluence and the repetitive rate.In exemplary embodiment, apply " series that applies is fast hanged down the fluence pulse " of light.Therefore, in exemplary embodiment, the average pulse fluence of these a plurality of light pulses is at most 3 (J*s)/cm^2 at the most with the ratio of the repetitive rate of these a plurality of light pulses, perhaps 2 (J*s)/cm^2 at the most, the perhaps maximum ratio of 1.5 (J*s)/cm^2 at the most.
f) mean power characteristic.In some embodiments, minimum average B configuration power (i.e. incoherent the and/or coherent light with the minimum average B configuration power delivery) is provided, this is to be heated on the minimum corium heating-up temperature in order to ensure hypodermic layer (being corium) (or its part).
For example, in the preset time section, (that is, corium is heated in enough time of 42 or 45 degrees centigrade) the minimum average B configuration power that 35 watts or 50 watts or 75 watts are provided at least.
In another example, 8 watts/centimetre are provided in the section in preset time
2, or 12 watts/centimetre
2, or 15 watts/centimetre
2The minimum average B configuration power density.
Do not hope by theory; Notice, through in a certain preset time of section (for example, at least 0.5 second; Or at least 1 second; Or at least 2 seconds etc.-or carried therebetween a certain minimum number pulse the time period-for example, at least 3,5,10,15 or 30 pulses) operate with the mean power of ' height ' relatively, might provide enough power to heat hypodermic layer or corium.
In some embodiments, maximum average power (and/or maximum average power of the light in some wavelength) is provided, for example, this is for the therapy that a kind of safety is provided and/or wherein has the therapy of the needs of less cooling corium.Therefore, in exemplary embodiment, this mean power is less than 400 watts, or less than 300 watts, or less than 200 watts, or less than 150 watts.
Exemplary therapeutic equipment
Figure 1A-1C provides the block diagram according to the demonstration equipment of exemplary embodiment of the present invention.These figure (and all charts) are intended to property as an example rather than restrictive.
This equipment comprises pulse incoherent light source 110 (for example flash lamp), controller 215 (in the specific embodiment of this figure, as the part of control unit 116 and provide) and applies device 114.
Make and apply device 114 and be suitable for carrying light to patient's area for treatment.In some embodiments, apply device 114 and comprise shell with the hole that is used to carry light pulse.In some embodiments, can provide control to apply the device size to confirm or to control.
Notice, be used for carrying light radiation being known in the art with the device 114 that applies that loses hair or feathers to skin, and any known device 114 and any known device that is used for losing hair or feathers that the device characteristic can be used in this description that applies of applying.
In some embodiments, apply device and can comprise the control of certain embedding and/or related with the control of certain embedding, for example, button is used for controlling the radiation of being carried-for example, ' ON/OFF ' control.
Be shown as and contact skin (promptly contacting with epidermis 52) although in Figure 1A, apply device 114, this can not be interpreted as a kind of restriction, and the embodiment that under the situation of contacting skin not, light is imposed on skin is equally within scope of the present invention.
In Figure 1B, apply device 114 at " top " of skin surface (promptly not contacting skin), make and between bottom that applies device 114 and skin surface, leave the gap that length is d1.
In Fig. 1 C, apply device 114 and comprise transparent energy delivery element 45, incoherent light (and other optional electromagnetic energy) is applied to skin surface 49 through this element.Energy delivery element 45 is configured to make in applying device 114 and between lower surface of transparent energy delivery element 45 (or energy delivery surface 43) and skin surface, leaves ' at interval ' or ' gap ' that length is d2.
Shown in Figure 1A-1C; Control unit 116 (for example comprises controller 215; Perhaps (i) autoelectrinic control for example comprises microprocessor and/or code, and it provides through the combination in any of using software and hardware; And/or (ii) manually control), the various parameters of the electromagnetic radiation of its control impuls light source 110 emissions.
Therefore, notice that in the instantiation of Figure 1A-1C and Fig. 2, controller 215 independent (and independently unit in) provides with applying device 114 in light source 110.This can not be interpreted as a kind of restriction.In some embodiments, can ' controller ' 215 be configured to the major part of light source 110 or as the major part such as the incoherent light equipment (promptly comprising light source 110) of flash unit (promptly being configured to generate the light source of required pulse train inherently).And, do not had the independence ' demand of control unit 116 '.
In the instance of Figure 1A-1C, light-pulse generator 110 is embedded in and applies within the device 114.Selectively or additionally, in some instances, light-pulse generator 110 is positioned at the outside that applies device 114, and light is from ' outside ' light source, for example via certain waveguide or conduit, is transported to and applies within the device 114.
In exemplary embodiment, cool off so that cooling to be provided applying device 114, apply the contact cooling (for example, such as the refrigerative contact cooling of sapphire contact) that device provides such as use.In the embodiment relevant, good thermo-contact can be provided preferably with the contact cooling.
It is understandable that,, can use the combination in any of cooling technology, comprise pre-cooling, parallel cooling, atomizing cooling, gel cooling and air cooling etc. although there is not cooling requirement.
In exemplary embodiment, before treat with light pulse and/or during and/or apply cooling afterwards.In exemplary embodiment, the amount of cooling (for example, contact cooling and/or atomizing cooling or any other cooling) is definite by control unit 116 (for example, controller 215), for example, and according to one or more parameters of pulsed light.
In exemplary embodiment, light penetrates corium 54 with the corium heating, for example, arrives at least 42 degrees centigrade or at least 45 degrees centigrade.In exemplary embodiment, hair follicle 50 is heated to the temperature higher than dermal temperature, for example, be heated to thermal denaturation temperature, although this is optional and might destroy hair follicle not needing hair follicle is heated under the situation of denaturation temperature.
Do not hope to be noticed that in exemplary embodiment, because the warm temperature of corium, hair follicle can not be cooled to below the dermal temperature in the section between at a time by theory.When this thing happens, can, for example, lose hair or feathers through waiting for methods such as alopecia and/or use tweezers.
In some embodiments; The area of the dermal zone that is heated (or hypodermic layer) is at least 20% of any speckle area disclosed herein (spot area); Or at least 50%, or at least 80%, and be heated the shortest time period-for example; At least 0.5 second, at least 1 second, at least 2 seconds, perhaps be effective to reach any other times section of the heating to hair follicle (with heat damage) that needs to hair follicle.
Fig. 2 provides the block diagram of exemplary control unit 116.As early notice, various parameters can perhaps manually be confirmed by the operator, and/or can use electronic circuit to calculate.Yet, provide some ' pre-programmed option ' will be more convenient.
The control unit 116 of the instance of Fig. 2 comprises controller 215.Controller 215 is used for controlling at least in part more than one pulse characteristics; The persistent period (being pulse width), power parameter that include but not limited to pulse fluence, each pulse are (for example; Mean power and/or peak power), the persistent period of pulse train, the number of pulses in the pulse train, and pulsation rate.
Therefore; In the instance of Fig. 2; Controller 215 comprises one or more in following: repetitive rate selector 210, fluence selector 212, each pulse duration (or pulse width) selector 217, power selector 214 (are used to confirm; For example, peak power and/or mean power and/or the two derived parameter), and the number of pulses selector 213 in pulse train duration selector and/or the pulse train.
Therefore; In different embodiment; Controller 215 can be used for or programme with a certain pulse train of the pulse that the minimum number at least that comprises given repetitive rate is provided (for example, at least 3 pulses, at least 5 pulses, at least 10 pulses, at least 15 pulses or at least 30 pulses).
In some embodiments; With control unit 116 ' pre-configured ' is that the selected therapeutic scheme that is used to lose hair or feathers described herein (for example, having described described any therapeutic scheme of repetitive rate and/or light pulse fluence and/or pulse width and/or pulse duration and/or power parameter) is provided.In an example, the user can use certain user interface (not shown) of having utilized display 216 from a plurality of schemes, to select a given therapeutic scheme (for example, this disclosed scheme).
In some embodiments, more than one ' program ' relevant with given pulse train is provided, and the mechanism of selecting specific procedure is provided.In a particular instance, the user interface according to skin and/or hair color selection specific procedure is provided.
For example, ' light skin ' program can provide the pulse of higher fluence, and ' dark skin ' program can provide the pulse of low fluence, still, for example, has higher repetitive rate.
In exemplary embodiment, control unit comprises the user display that for example is used for option program.
Notice that in some embodiments, the user can specify first parameter or one group of parameter (for example, fluence), and another parameter (for example, repetitive rate) can confirmed or calculate to controller 215 from specified one or more parameters.
Notice that as shown in the figure, light source 110 ' embedding ' is applying in the device (for example, handpiece (handpiece)).Some embodiment provides this marked feature, but this can not be interpreted as a kind of restriction.
In exemplary embodiment, can provide an above user to import control (for example, keyboard, foot switch etc.) (not shown).
Fig. 3 provides the block diagram of exemplary light source 110 (being light-pulse generator and/or CW light).In the instance of Fig. 3, it comprises pulse generator 310 (for example, by device control cell control), light source 312 (for example, such as the incoherent light source of flash lamp), and optical module 314.
Can thereby optical module 314 be configured to revise the propagation of incoherent light electromagnetic radiation-for example be directed to the precalculated position in the predetermined direction direct light and/or with light.Optical module can comprise any suitable optics that is used to carry out this function known in those skilled in the art, includes but not limited to waveguide, lens (promptly including but not limited to refraction and diffraction lens), and reflecting mirror.Alternatively, relate in the embodiment based on the depilation of incoherent light at some, optical module 314 can comprise band filter, for example, is used for carry out the low pass filter of filtering from the incoherent light of flash lamp.
Flash lamp or other incoherent light sources can be programmed so that the light of different wavelength range to be provided.
Notice, to the not restriction of shape of light pulse.In exemplary embodiment, pulse be shaped as square, although this of course not a kind of restriction, and the pulse of Any shape (for example, sinusoidal (sinosiodal), zigzag etc.) is all within scope of the present invention.
In relating to the exemplary embodiment of incoherent light, speckle area or speckle size exist, for example, and between 3cm^2 and the 10cm^2-for example, between 3cm^2 and 7cm^2.
In some embodiments, interpulse time-preserving.Selectively, can change this parameter, so that the repetitive rate of variation to be provided.
A marked feature that is provided by control unit in some embodiments is, light pulse can have different predetermined light radiation and/or pulse parameter, for example, and predetermined wavelength, fluence, repetitive rate and pulse shape etc.
Notice, in some embodiments, can follow light pulse to apply the electromagnetic radiation (for example, radio-frequency radiation) except that light radiation.Yet this is not a kind of restriction, and wherein the overall strength of this non-light energy be at most total electromagnetic radiation intensity 10% embodiment within scope of the present invention.Typically, do not apply radio-frequency radiation, and only apply light (coherent light and/or incoherent light), although this can not be interpreted as a kind of restriction.
Notice that as above-mentioned various parameters can randomly in time change, for example, repetitive rate, pulse shape and pulse width etc.
Notice, in various embodiments, apply the electromagnetic radiation that comprises light pulse with at the surrounding tissue/skin of not burning, and/or lose hair or feathers under the situation of staying damage for surrounding tissue/skin (temporary and/or permanent hair removal).
Additional discussion to therapeutic scheme
In some embodiments, the treatment to the patient comprises the steps: that wherein there is the patient zone zone of hair follicle (or need therefrom destroy) of hair follicle in (i) identification; (ii) apply the electromagnetic radiation that comprises a plurality of incoherent light pulses; (iii) allow hair follicle to be destroyed by the electromagnetic radiation that is applied.
Handpiece or apply device speed
Do not hope to be noticed, use pulse transfer rate or frequency to allow through applying light pulse at the handpiece that skin surface moves with speed relative to ' height ' relative to ' height ' by any theory.This be because, when the pulse transfer rate is higher, carried more each pulse in the section in preset time, therefore, even handpiece speed relatively ' height ', given hair follicle still can receive the pulse of minimum number.
In exemplary embodiment, on an average, each hair follicle in the given area for treatment (for example, 1cm^2 or 5cm^2 or 10cm^2 or the given area for treatment of 50cm^2 at least at least at least at least) receives 10 to 15 pulses.Be recognized that, according to concrete application, have some clinical settings, wherein, for example, given hair follicle stands at least 5,20 perhaps pulses of any other quantity of pulses at the most.
In some embodiments; A plurality of light pulses apply through in the time period of carrying these a plurality of light pulses with given minimum average B configuration repetitive rate (for example; In the time period of having carried at least 10 pulses; Perhaps in the time period of having carried at least 20 pulses; Perhaps in the time period of having carried at least 50 pulses, perhaps in the time period of having carried at least 75 pulses, perhaps in the time period of having carried at least 100 pulses) with 3cm/sec (or 4cm/sec at least at least on an average; Or approximate 5cm/sec) speed (promptly on skin surface) on the treatment surface moves or the applying device or handpiece (for example, provide concomitantly include but not limited to the refrigerative device that applies of contact) and carry out of ' slip '.
As used herein; ' speed ' that applies device or handpiece (for example refers to when applying device or handpiece and on area for treatment or skin surface, move; The part plan that is parallel to area for treatment), this applies fixing point (for example, the barycenter on device or the handpiece; Or in another example, at the lip-deep fixing point of energy therapy) with respect to the speed of area for treatment or skin.
Generally acknowledge be; In different application; Light pulse apply or carry during the minimum or the Mean Speed of required handpiece can change according to this application-promptly, according to invasion and attack level parameters such as (aggressiveness) such as repetitive rate, speckle area, required treatment.
Therefore, in an example,, might during carry, have the handpiece of higher rate or apply device conveying light pulse in pulse if repetitive rate is higher.In another example, bigger speckle area also will allow higher handpiece or apply device speed.
In some embodiments, the average handpiece speed during (being the conveying of incoherent light pulses) carried in pulse is 3cm/sec at least, or 4cm/sec at least, or about 5cm/sec.In some embodiments; Carrying in the time period of a plurality of incoherent light pulses, confirming average handpiece or apply device speed v to make ratio (v^2)/[(freq) ^2* (spot)] (wherein v is for being the handpiece of unit with cm/sec or applying device speed, spot for be the speckle area of unit) be at least 0.1 with cm^2; Or at least 0.3; Or at least 0.5, or at least 0.7, or at least 1.
Do not hope to be noticed that in some embodiments, the doctor that the treatment patient carries out alopecia can select to adopt the speed of ' comparatively fast ' or ' higher ' so that alopeciaing therapeutic faster to be provided by theory.
The order treatment of the subregion of area for treatment
Fig. 4 A provides the explanation of exemplary area for treatment 500.Notice that each in the subregion all is Mathematics structural.Although can not be interpreted as a kind of restriction, in the instance of Fig. 4 A, each subregion has rectangular shape (and overall area for treatment 500 has rectangular shape).According to the instance of Fig. 4 A-4B, the doctor who the patient is provided depilation treatment applies light pulse to the zones of different or the subregion of area for treatment 500, for example, is used to cross over the handpiece that area for treatment is carried light pulse through moving.
Therefore, can apply treatment in order.In a specific instance, in the therapeutic process of area for treatment 500, treat 511 first subregions ' A ' 502 with a plurality of light pulses; Treat 513 first subregions ' B ' 504 with a plurality of light pulses then; Treat 515 first subregions ' C ' 506 with a plurality of light pulses then; Treat 517 first subregions ' D ' 508 with a plurality of light pulses then; Treat 519 first subregions ' E ' 510 with a plurality of light pulses then.
It is inferior arbitrarily to repeat this process.Shown in Fig. 5 A, mark i representes the i time treatment of carrying out to stator region.
In the instance of Fig. 4 A-4B, when treating to stator region, other subregions can not be attempted (promptly because of handpiece or apply device in another position).Therefore, at interval t
1 1In at first treat subregion ' A '.Then, comprising interval t
2 1, t
3 1, t
4 1, t
5 1And t
6 1' static ' interval in, apply other subregions of device treatment (being that subregion ' B ' is to ' F ').Therefore, in ' static ' interval, subregion ' A ' 502 does not receive light pulse.Subsequently, at interval t
1 2In, subregion ' A ' 502 stands more than 511 light pulse once more.
Therefore, the described process of Fig. 5 B is the particular instance (being that each subregion intermittently stands a plurality of light pulses) that a light pulse ' intermittence ' applies, and it is described hereinafter.
Given position intermittence on the patient skin is applied light pulse so that depilation
In some embodiments, not continuously or immediately all pulses to be flowed to given position or given hair follicle on the skin.
Therefore; As described with reference to figure 4A-4B; Might be with given first subregion of a plurality of pulse therapies; Treat thereafter second subregion (for example, for example through will apply device from the skin of institute's area for treatment slide with arrive second subregion with handpiece or apply device and move to second subregion from first subregion), this first subregion will receive additional light pulse thereafter.
Selectively or additionally, in the instance that the intermittence of another light pulse applies, can carry the pulse of some to a certain zone; Thereafter, in a period of time, not (not for example to the area for treatment transport pulse; This operation temporarily stop pulse is carried, and for example, uses foot switch); Once more carry the pulse of some thereafter.
And, it is understandable that in some embodiments, the speed that applies device can be the function of the size of institute's area for treatment.
Fig. 5 provides the motion pattern of example procedure; Wherein the light pulse that applied-promptly in very first time section, apply light pulse (step 401) is stood in the given position of tissue or zone intermittently, thereafter, and in second time period (step 403); The given position of this tissue or zone do not receive light pulse; Thereafter, in the 3rd time period (being repeating step 401), the light pulse that applied is stood in the given position of this tissue or zone once more.Can repeating step 401 and 403 arbitrarily time so that from given position or zone depilation.
Therefore, in step 401, apply a series of light pulses and make it carry (the pulse P that promptly comprises minimum number) with given repetitive rate.In an example, these pulses have and are less than each pulse 8J/cm^2 and the mean fluence of each pulse 0.5J/cm^2 at least.
As used herein, carry or apply an above incoherent light pulses to an area or zone to comprise to an above position transport pulse in this area or the zone.
Notice; In some embodiments; The quantity of the pulse P that carry (promptly to an above position in this area or the zone) in step 401 pair this area or zone depends on the size in this zone, and wherein, the zone can receive than multiple-pulse greatly; For example, because big zone has big ' capacity ' with the more multiposition place received pulse in this big zone.
Therefore, in an example, if organize the area size to be Ncm^2, (surface area that promptly has N cm^2), the number of pulses of carrying in step 401 is at least the smallest positive integral bigger than 1.5N.
According to present embodiment, the value of N can the scope between 1 to 20, between 1.5 to 15, between 2 to 15 in, and in other subranges.
In a particular instance, size can receive 2 pulses for the area (being an example of step 401) in once given ' process ' of handpiece of organizing of 1cm^2.Similarly, in this example, size in this particular instance, can receive 8 pulses for the area of organizing of 4cm^2 in once given ' process ' of handpiece.
With reference now to step 403; Notice; After being in application to few P light pulse, this zone or area (it can be the subregion of big area for treatment, also can not be) can stand resting stage; Wherein or not carry light pulse (promptly to any position in this zone or the area), perhaps only this zone or area are applied or carry the light of the mean power with reduction.
In the time period of step 403, can allow the cooling before repeating step 401 of this given area or area.This can be used to the treatment that provides safe.
In an example, wherein in the time period of step 403, apply device and apply energy elsewhere, in any case, in resting stage, need not apply energy.This describes in Fig. 4 A-4B.Therefore, to subregion ' A ' 502, at interval t
1 1The execution first of interior execution in step 401.Comprising interval t
2 1, t
3 1, t
4 1, t
5 1, t
5 1And t
1 6Interval in the execution first of execution in step 403.At interval t
1 2Carry out the second time of interior execution in step 401.
To subregion ' B ' 504, at interval t
2 1The execution first of interior execution in step 401.Comprising interval t
3 1, t
4 1, t
5 1, t
1 6And t
1 2Interval in the execution first of execution in step 403.At interval t
2 2Carry out the second time of interior execution in step 401.
Notice that in various embodiments, can be ' not applying the energy phase ' or ' applying the low-yield relatively phase ' this resting stage.
In an example, in ' resting stage ' of step 403, carried (for example; Carry the handpiece of a plurality of light pulses or apply that device carries in step 401 through being used for) mean power (or the total amount of light of light; Or in the total amount of 750nm light in the spectral region of 1500nm) be no more than a certain ' low-power ' numerical value-for example, be no more than described 30 watts, perhaps be no more than 20 watts; Perhaps be no more than 10 watts, perhaps be no more than 5 watts.
In different embodiment, the persistent period of ' static ' phase can be for example, the invasion and attack level required according to treatment; And/or the size in overall ' treatment ' zone; And/or patient's body parameter (for example, hair or skin color), an and/or above various factors and changing.
The technological doctor who applies treatment confirms the length of ' static ' phase according to a lot of embodiment.Therefore, in different instances, the persistent period of ' resting stage ' of step 403 continues to depend on the minimum time of an above factor.Therefore; For example, given hair follicle can stand ' resting stage ' in a time quantum, and this time quantum was at least several seconds; And be at most time period of the order of magnitude of depilation treatment persistent period---promptly be at most some minutes (for example, be at most 20 minutes or 30 minutes or 60 minutes).
In an example, for example with Fig. 5 A in example class seemingly, can influence the length of resting stage with respect to the stator region size of giving of overall area for treatment size.Therefore, if give the size of stator region little with respect to the size of overall area for treatment, this possibly increase the time span of ' resting stage ' of step 403.If give stator region bigger with respect to overall area for treatment size, this possibly reduce the time span of ' resting stage ' of step 403.
Notice that the sum of the pulse of being carried can depend on the size of area for treatment 500.In an example, can be changed to the pulse that is delivered to few some (or to its programming to carry pulse of any amount) with this equipment is prewired, for example, at least 15, at least 30, at least 50, at least 100, and at least 500.And, in different instances, providing user or the doctor of depilation treatment can control and carrying (temporarily or fully) with stop pulse.
Following instance only is considered to be illustrative and nonrestrictive in essence.Obviously, it will be apparent to those skilled in the art that the present invention under the situation of not leaving the scope of the invention, can make modification, displacement and variation.
Instance
The inventor has implemented various experiments and has carried out mankind's depilation with checking according to disclosed herein the instruction more than one through applying light radiation.In instance 1, some in the experiment of being implemented have been described.In instance 2, additional exemplary scenario and equipment configuration parameter relate to described incoherent light.
Instance 1: use incoherent intense pulsed light depilation
The inventor has implemented exemplary flash lamp Depilatory device, and according to some this equipment of instruction configuration of the present invention.The inventor has implemented some experiment to illustrate the depilation of using the said equipment to carry out.
In demonstration equipment, use low pass filter that wavelength is shorter than 780nm and the light of being longer than 1300nm carries out filtering.
The table 2 that below shows has been listed the various light field configuration parameters that during a particular experiment, use.At this experimental session, skin has been applied a series of square-wave pulses, wherein right for all pulses, pulse between time equate.
Parameter value
Fluence 5J/cm^2
Pulse duration 6ms
Speckle area 6.4cm^2
Pulse frequency (repetitive rate) 3 pulse/sec
Peak power 5 * 1/0.006 * 6.4=5,330W
Mean power 5 * 6.4 * 3=96W
Instance 2: use incoherent intense pulsed light depilation
Instance 2 has been described the optional equipment that relates to incoherent light (for example, IPL or flash of light) or has been treated non-limiting parameter.
Parameter value
Fluence 2J/cm^2
Pulse duration 2ms
Speckle area 6.4cm^2
Pulse frequency (repetitive rate) 10 pulse/sec
Peak power 2 * 1/0.002 * 6.4=6,400W
Mean power 2 * 6.4 * 10=128W
In description of the present invention and claims; Verb " comprises " each in " comprising " and " having "; And its variation, be used to represent the tabulation fully of composition, component, element or the part of the subject that the object of this verb need not this verb.
All references of quoting here, its full content is incorporated into through reference.It is prior art that the quoting of reference do not constitute this reference of approval.
Article used herein " one " relates to one or more (being at least one) of the grammatical object of this article.Through instance, " element " element of expression or an above element.
Term used herein " comprises " that the expression phrase " includes but not limited to ", and can use with its exchange.
Term used herein " or " the expression term " and/or ", and can use with its exchange, only if other aspects obviously pointed out in context.
Term used herein " such as " the expression phrase " such as but be not limited to ", and can use with its exchange.
The present invention describes through the detailed description of using its embodiment, through instance this embodiment is provided, and it is not intended to limit scope of the present invention.Described embodiment comprises different character, and not every characteristic all need be in all of the embodiments of the present invention.Embodiments more of the present invention have only utilized possibly making up of some these characteristics or this characteristic.Those skilled in the art can change described embodiment of the present invention, and can the embodiment of the present invention of the various combination that comprises the characteristic of noticing in the described embodiment be changed.
Claims (7)
1. device that in containing the skin area of a plurality of hair follicles, destroys hair follicle, said device comprises:
A) incoherent light source is used to generate the incoherent light that comprises a plurality of incoherent light pulses, and each said incoherent light pulses mainly is included in the minimum wavelength value of at least 750 nanometers and the wavelength in the scope between the maxima of waves long value of 1500 nanometers at the most; And
B) controller is used for controlling at least in part the pulse characteristics of said a plurality of incoherent light pulses, and said light source and said controller are configured so that:
I) the average pulse fluence of said a plurality of incoherent light pulses is the minimum fluence value of at least 0.5 Jiao/square centimeter, and is the maximum fluence value of 10 Jiao/square centimeters at the most;
Ii) the average repetitive rate of said a plurality of incoherent light pulses is at least 1.5 hertz a repetition values, is 20 hertz repetition values at the most;
Iii) the average pulse persistent period of said a plurality of incoherent light pulses is at least 1 millisecond,
Wherein, Said light source and said controller are configured so that the electromagnetic radiation that applies is heated to the said hypodermic layer of said skin area the minimum temperature of minimum 42 degree effectively; The maximum temperature of 50 degree at the most, and said electromagnetic radiation is applied to any one position in the said skin area.
2. device as claimed in claim 1 also comprises:
C) be used for said a plurality of incoherent light pulses are delivered to the device that applies of said skin area.
3. according to claim 1 or claim 2 device wherein, is configured so that with said light source and said controller said minimum temperature is at least 45 degree.
4. device as claimed in claim 1 wherein, is configured to said light source and said controller to be provided as the mean power of at least 75 watts minimum average B configuration performance number.
5. device as claimed in claim 1 wherein, is configured so that with said light source and said controller said repetition values is at least 2 hertz.
6. device as claimed in claim 1 wherein, is configured so that with said light source and said controller said repetition values is at least 5 hertz.
7. device as claimed in claim 1 wherein, is configured so that with said light source and said controller said maximum mean fluence value is at most 6 Jiao/square centimeters.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77840306P | 2006-03-03 | 2006-03-03 | |
| US60/778,403 | 2006-03-03 | ||
| US85342106P | 2006-10-23 | 2006-10-23 | |
| US60/853,421 | 2006-10-23 | ||
| PCT/IL2007/000275 WO2007099546A2 (en) | 2006-03-03 | 2007-03-04 | Method and apparatus for light-based hair removal using incoherent light pulses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101495062A CN101495062A (en) | 2009-07-29 |
| CN101495062B true CN101495062B (en) | 2012-10-24 |
Family
ID=40925311
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780010851.2A Active CN101553279B (en) | 2006-03-03 | 2007-03-04 | Method and apparatus for light-based hair removal |
| CN2007800055356A Expired - Fee Related CN101495062B (en) | 2006-03-03 | 2007-03-04 | Apparatus for light-based hair removal using incoherent light pulses |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780010851.2A Active CN101553279B (en) | 2006-03-03 | 2007-03-04 | Method and apparatus for light-based hair removal |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN101553279B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3026197A1 (en) * | 2016-06-24 | 2017-12-28 | Lumenis Ltd | Selective skin treatments utilizing laser-equivalent intense pulsed light devices |
| CN106178286B (en) * | 2016-08-25 | 2019-02-05 | 山东杰美医疗科技有限公司 | The high-power semiconductor laser depilation system of intelligent recognition multi-wavelength, more treatment heads |
| CN109603013B (en) * | 2018-11-23 | 2019-09-20 | 北京镭特医疗科技有限公司 | A kind of multifunctional combination beauty instrument and its working method |
| CN112690898A (en) * | 2021-01-22 | 2021-04-23 | 江苏利孚医疗技术有限公司 | Unhairing module, unhairing instrument and method using unhairing instrument |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2045931U (en) * | 1987-09-29 | 1989-10-18 | 中国科学院武汉物理研究所 | Electronic hair-removing device |
| US6050990A (en) * | 1996-12-05 | 2000-04-18 | Thermolase Corporation | Methods and devices for inhibiting hair growth and related skin treatments |
| US6168590B1 (en) * | 1997-08-12 | 2001-01-02 | Y-Beam Technologies, Inc. | Method for permanent hair removal |
| CN1283130A (en) * | 1997-12-31 | 2001-02-07 | 莱蒂恩思公司 | Apparatus and method for removing hair |
| US6235015B1 (en) * | 1997-05-14 | 2001-05-22 | Applied Optronics Corporation | Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm |
| US6514254B1 (en) * | 2000-09-25 | 2003-02-04 | John W. Falls | Clamp device for orthopedic external fixator |
-
2007
- 2007-03-04 CN CN200780010851.2A patent/CN101553279B/en active Active
- 2007-03-04 CN CN2007800055356A patent/CN101495062B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2045931U (en) * | 1987-09-29 | 1989-10-18 | 中国科学院武汉物理研究所 | Electronic hair-removing device |
| US6050990A (en) * | 1996-12-05 | 2000-04-18 | Thermolase Corporation | Methods and devices for inhibiting hair growth and related skin treatments |
| US6235015B1 (en) * | 1997-05-14 | 2001-05-22 | Applied Optronics Corporation | Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm |
| US6168590B1 (en) * | 1997-08-12 | 2001-01-02 | Y-Beam Technologies, Inc. | Method for permanent hair removal |
| CN1283130A (en) * | 1997-12-31 | 2001-02-07 | 莱蒂恩思公司 | Apparatus and method for removing hair |
| US6514254B1 (en) * | 2000-09-25 | 2003-02-04 | John W. Falls | Clamp device for orthopedic external fixator |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101553279B (en) | 2015-07-08 |
| CN101495062A (en) | 2009-07-29 |
| CN101553279A (en) | 2009-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2640132C (en) | Method and apparatus for light-based hair removal using incoherent light pulses | |
| US20090012585A1 (en) | Method and apparatus for light-based hair removal using incoherent light pulses | |
| US7097639B1 (en) | Dual filter multiple pulse photo-dermatological device with pre/post optical heating, quasi-logarithmic spacing, and laser rod spectrum infusion | |
| KR101272372B1 (en) | Device for treating skin | |
| AU2003238302B2 (en) | Method and apparatus for photothermal treatment of tissue at depth | |
| US7465307B2 (en) | Tissue treatment system | |
| MXPA01008995A (en) | Skin wrinkle reduction using pulsed light. | |
| KR20100065297A (en) | Method and device for collagen growth stimulation | |
| KR20050026404A (en) | Method and apparatus for photothermal treatment of tissue at depth | |
| EP2277589B1 (en) | System for controlling non-coherent pulsed light | |
| WO2006089227A2 (en) | Dermatological treatment device | |
| JP2003521305A (en) | Method and apparatus for performing medical treatment using long-term electromagnetic radiation | |
| WO2003003903A2 (en) | Laser device for medical/cosmetic procedures | |
| JP2007061641A (en) | Method and apparatus for depilation using pulsed electromagnetic radiation | |
| JPH09215695A (en) | Epilation method and apparatus using pulse electromagnetic radiation | |
| CN101495062B (en) | Apparatus for light-based hair removal using incoherent light pulses |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121024 Termination date: 20200304 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |