CN101495173A - 肠胃器官的随机刺激 - Google Patents

肠胃器官的随机刺激 Download PDF

Info

Publication number
CN101495173A
CN101495173A CNA2006800384664A CN200680038466A CN101495173A CN 101495173 A CN101495173 A CN 101495173A CN A2006800384664 A CNA2006800384664 A CN A2006800384664A CN 200680038466 A CN200680038466 A CN 200680038466A CN 101495173 A CN101495173 A CN 101495173A
Authority
CN
China
Prior art keywords
parameter
signal
pulse
select
digestive organs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800384664A
Other languages
English (en)
Inventor
米尔·A·伊姆兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IntraPace Inc
Original Assignee
IntraPace Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IntraPace Inc filed Critical IntraPace Inc
Publication of CN101495173A publication Critical patent/CN101495173A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

提供一种用于刺激消化器官的设备、系统和方法，其中，所述刺激被随机化。

Description

肠胃器官的随机刺激
相关申请的交叉引用
本申请是正式申请，其要求美国专利申请No.11/219,004(申请日为1996年9月9日)的优先权，在这里通过引用将其全文并入。
技术领域
本发明涉及一种用于刺激胃壁的设备系统和方法。
背景技术
已经提出了多种设备来刺激胃的胃壁和其它肠胃器官。已经提出了各种不同的刺激参数。
然而，人们认为，利用现在已经提出的设备和刺激参数，肠胃或其它消化器官将适应刺激或变得对刺激不敏感，尤其是如果这种刺激以非生理速率被给予较长时间。因此，期望提供一种可以减少对刺激的适应和不敏感的消化器官刺激设备、系统和/或方法。
已经提出了一些使用具有定相关系的多个电极以便在一些情况下沿着蠕动流程来刺激消化道器官的设备。但是，也有人认为胃、肠胃或其它消化器官将随着时间适应这样的定相刺激。因此，期望提供一种可以减少对多个电极的刺激的适应和/或不敏感的消化器官刺激设备、系统和/或方法。
发明内容
本发明提供一种用于随机刺激消化器官的设备、系统和方法。
本发明的一个方面提供一种旨在减少消化器官对电刺激的适应或不敏感的设备系统和方法。根据本发明的一个方面，所述设备被编程为伪随机地选择刺激参数并给予消化器官伪随机刺激。这里所使用的伪随机意指包括在预设标准或限制内的随机选择。所述限制或标准可以包括例如在预选或预定刺激参数窗口内的刺激。也可以采用大量已知或专属方法和设备中的任何一个来计算、产生和/或选择伪随机参数。典型地，所选择的随机或伪随机刺激参数将典型地足够不规则或不定期，以抑制组织适应。
本发明包括如权利要求书中所请求的那些发明。
在下面的详细论述中描述本发明的各种实施例和各个方面。
附图说明
图1是已经应用于消化器官的示例性刺激信号的示意图。
图2是已经应用于消化器官的示例性刺激信号的示意图。
图3是使用多个电极的示例性定相刺激的示意图。
图4是根据本发明的刺激信号的示意图。
图5是根据本发明的刺激信号的示意图。
图6是根据本发明的刺激信号的示意图。
图7是根据本发明的刺激信号的示意图。
图8是根据本发明的刺激信号的示意图。
图9是根据本发明的刺激信号的示意图。
图10是说明根据本发明的刺激设备的操作的流程图。
图11是说明根据本发明的刺激设备的操作的流程图。
图12是根据本发明的刺激设备。
具体实施方式
根据本发明的一个方面，提供一种用于刺激消化器官的设备。所述设备可以刺激任何一个或多个消化器官，例如包括分泌消化物质、消化调节激素等等的部分胃肠道或消化器官。根据一个实施例，提供一种用于刺激胃的设备。
可以提供刺激以引起一个或多个期望的效果或反应。可以提供刺激来控制消化、产生过饱的感觉、控制食物在胃肠道内的移动、调节消化过程或调节饥饿等等。这样的刺激设备的一个示例描述于美国专利No.6,535,764中，在这里通过引用将其并入。
根据本发明的一个方面，提供一种设备，其被编程为随机地(或伪随机地)选择或改变一个或多个刺激参数，并根据选择的参数给予消化器官刺激。根据一个方面，随机地(或伪随机地)选择或改变刺激，以减少消化器官对刺激(尤其是以非生理速率的刺激)的适应或不敏感。
被编程的设备可以随机地(或伪随机地)从可接受参数的窗口或随机化窗口内选择或产生参数。这种参数可以包括但不局限于例如脉冲宽度、脉冲重复率、脉冲串频率、脉冲串重复率、每个脉冲串的脉冲。被编程的设备还可以在窗口内或根据选择标准随机地(或伪随机地)选择或改变脉冲幅值、脉冲形状和脉冲串包络。被编程的设备可以在刺激之前或刺激期间随机地(或伪随机地)选择或改变这些参数或其它参数中的任何一个或多个。
被编程的设备也可以随机地(或伪随机地)逐个脉冲或逐个脉冲串地选择或改变刺激。被编程的设备可以操作为周期性地改变参数，或者可以响应于感测到正在发生适应或不敏感或者刺激正在失效或接收到这样的反馈而改变参数。根据本发明的一个方面，例如，所述设备可以使用收缩监测设备(例如应变仪或其它收缩传感器)来监测随着时间的刺激响应。如果设备检测到次最优刺激响应，则设备接着可以随机或伪随机地选择下一个参数或参数集。
根据本发明的另一方面，所述被编程的设备可以在多个刺激点随机地(或伪随机地)选择或改变刺激。这些点中的每一个可以具有电分离的刺激电极，其中每个点处的刺激参数独立于其它点处的刺激。也可以随机地(或伪随机地)选择或改变刺激序列或序列的定时。因此，在各个点处没有特定的刺激定相。
参考图1，示出了已经用于刺激消化器官的典型刺激信号的示例。所述信号包括一系列脉冲。所述脉冲具有脉冲幅值PA1、脉冲宽度PW1，并以脉冲重复率PRR1重复。所述脉冲重复率是一个脉冲的启动时间到下一个脉冲的启动时间。所述参数通常被预设，或者被选择或选取用于处理。
参考图2，示出了已经用于刺激消化道器官的典型刺激信号的示例。所述信号包括脉冲的重复脉冲串的图案，其以脉冲串重复率BRR2重复。也就是说，所述脉冲串重复率是一个脉冲串的启动时间到下一个脉冲串的启动时间。脉冲串内的脉冲具有脉冲幅值PA和脉冲串频率BF2。所述脉冲串持续时间为BD2，并且每个脉冲串包括一定数量的脉冲PPB2。所述参数通常被预设，或者被选择用于处理。
参考图3，示出了典型的多电极刺激的示例。通过电极1给予刺激信号。电极2处的刺激相对于电极1处的刺激信号以相位角Ψ定相，Ψ表示启动电极1处的信号和启动电极2处的信号之间的时间。电极1和电极2处的信号也可以重叠。
图4示出了根据本发明的随机化刺激信号的示例，其可以由被编程设备随机地(或伪随机地)选择并给予消化器官。图4中所示的信号的脉冲宽度随机地变化，第一脉冲宽度为PWa，第二脉冲宽度为PWb，第三为PWc，以及第四为PWd。这些脉冲宽度被选择并给予。所述脉冲宽度可以在脉冲宽度的预选范围内。例如，在一个变化中，它们可以从每分钟1-20个脉冲变化。
图5示出信号的示例，其由被编程的设备随机地(或伪随机地)选择并由根据本发明的设备或系统给予。所述脉冲以变化和随机速率重复。第一脉冲的脉冲重复率为PRRa，此后第二脉冲被启动。第二脉冲的脉冲重复率为PRRb，此后第三脉冲被启动。第三脉冲的脉冲重复率为PRRc，此后第四脉冲被启动。第四脉冲的脉冲重速率为PRRd，此后第五脉冲被启动。第五脉冲的脉冲重复率为PRRe，此后第六脉冲被启动。所述脉冲宽度或其它参数也可以变化或不变化。
图6示出随机化信号的示例，其可以由根据本发明的被编程设备或系统随机地(或伪随机地)选择并给予。所述刺激信号包括一系列脉冲的脉冲串。脉冲的脉冲串以变化的随机速率重复。第一脉冲串的脉冲串重复率为BRRa，第二脉冲串的脉冲串重复率为BRRb，并且第三脉冲串的脉冲串重复率为BRRc。所述脉冲串频率或其它参数也可以变化。
图7示出随机化信号的示例，其可以由根据本发明的被编程设备或系统随机地(或伪随机地)选择并给予。所述刺激信号包括一系列脉冲的脉冲串。脉冲串的频率是随机变化的。脉冲的第一脉冲串的频率为BFa，脉冲的第二脉冲串的频率为BFb，脉冲的第三脉冲串的频率为BFc。其它参数也可以变化。
图8示出随机化信号的示例，其可以由根据本发明的系统设备随机地(或伪随机地)选择并给予。所述刺激信号包括一系列脉冲的脉冲串。脉冲的频率和脉冲串的重复率二者均随机变化。第一脉冲串的频率为BFd，脉冲串重复率为BRRd。第二脉冲串的频率为BFe，脉冲串重复率为BRRe。第三脉冲串的频率为BFf，脉冲串重复率为BRRf。
图4-8所示的随机化信号是一些可在刺激信号协议中随机化的参数的示例。可在任何一个处理协议中随机化这些参数中的任何一个或多个。所述随机化参数可以包括但不局限于下列参数中的一个或多个：脉冲宽度、脉冲幅值、脉冲重复率、脉冲串频率、脉冲串重复率。而且，每个脉冲(包括脉冲串内的脉冲)的形状可以变化。脉冲串的脉冲的包络形状可以变化。脉冲的脉冲串内的频率、脉冲宽度和幅值也可以变化。而且，一些参数可以变化同时其它参数保持不变。
各个随机化的参数可以由随机数发生器或控制器从参数窗口或参数组内随机地(或伪随机地)选择。所述参数窗口或参数组可被预先编程到刺激设备中并在处理过程中被随机地选择。
图9示出信号的随机化，例如参考图4-8所述的那些，其在多个电极点被随机施加。如图9所示，在第一时间周期t1内，在时刻ta在电极1处施加第一脉冲p1，在时刻tb在电极2处施加第二脉冲p2。在时间周期t2内，在随机的不同时刻在电极1处施加脉冲p3并在电极2处施加脉冲p4。类似地，在时间周期t3和t4内，在不同时刻在电极1和电极2处施加脉冲。
现在参考图12，示出根据本发明的刺激器120的示意图。消化器官刺激器可以包括任何刺激器，其包含电耦合至消化器官并被配置成给予消化器官刺激信号的电极。这样的刺激器的一个示例是配置成刺激胃的包括至少一个耦合至胃的电极和耦合至所述电极的脉冲发生器的设备。这样的电极可被植入胃，例如经过腹腔镜或内窥镜的开放手术。
如图12所示，根据本发明的一个示例的刺激器120包括CPU21，其包括具有查找表123的存储器设备122，其中刺激参数与例如在随机数范围内的随机数相关联。随机数发生器124耦合至CPU121，并且当被提示时，随机地产生对应于特定刺激参数的范围内的数。所述随机数发生器例如可以具有100个可能的随机数对应于给定类型的不同参数(例如1-100用于脉冲重复率以及101-200用于脉冲宽度等等)。所述随机数发生器也可以具有某些随机数，每一个对应于将给予的特定预定信号，所述信号可以改变一个或多个参数，或者可以具有刺激信号的变化形状或类型。
所产生的随机数标识刺激参数或存储在存储器设备122的查找表123中的参数。然后，CPU 121控制刺激输出125(例如至一个或多个电极)处的刺激，以向消化器官给予刺激，其中所述刺激对应于随机地(或伪随机地)产生或选择的刺激参数。可以使用一个以上的查找表和随机数发生器，其中多个刺激参数被随机化。
图10示出根据本发明的设备的示例性方法和操作。首先，在随机数的范围内产生随机数(100)。每个随机数对应于参数窗口或范围内的特定刺激信号或刺激参数(或参数组)。具有对应于所产生的随机数的参数的脉冲或脉冲串被产生并给予消化器官用于刺激(101)。然后，计时器被开启，以标识何时第一信号已被启动(102)，以及对应于刺激参数(或参数组)的特定刺激信号再次产生随机数(103)。并且，对于何时将给予下一个刺激脉冲或脉冲串进行计算(104)。给予时间的计算可以取决于哪个刺激参数正被随机化。如果脉冲重复率或脉冲串重复率是变化参数，则何时将分别给予下一个脉冲或脉冲串的计算将基于脉冲或脉冲串重复率的变化。如果脉冲重复率或脉冲串重复率是不变的，则所述给予时间的计算将是不变的或者基于不变的脉冲或脉冲串重复率。如果所述随机化将周期性地发生，则根据具有第一组刺激图案的协议给予刺激，直到计时器所确定的某个周期已经发生。当所述周期已经发生时，接下来根据刺激协议使用下一个随机化的刺激参数。如果刺激协议涉及在各种条件下打开或关闭刺激，则在打开刺激时开启计时器，并在关闭刺激时关掉计时器。作为选择，计时器可以连续地运转。
比较给予下一个信号的时间和计时器的时间(当前一个脉冲或脉冲串开始时)，以确定是否是给予下一个脉冲或脉冲串的时间。如果不是给予下一个脉冲或脉冲串的时间(106)，则再次进行比较(105)，直到是给予下一个脉冲或脉冲串的时间(106)，随之产生具有对应于所产生的随机数的参数的信号(101)，并且重复步骤102-106。
图11示出根据本发明的设备的方法和操作。首先，在随机数的范围内产生用于电极1的随机数(110)。然后，在随机数的范围内产生用于电极2的随机数(111)。每个随机数对应于特定刺激信号或参数窗口或范围内的刺激参数(或参数组)。然后，当脉冲或脉冲串周期开始时开启计时器(112)。具有对应于每个产生的用于电极1和2的随机数的参数的脉冲或脉冲串被产生并给予消化器官，用于在电极1和2处相应地刺激(113)。这些刺激信号彼此独立。但是，它们可以被定时以便落入预定脉冲重复率内，使得总体上在下一组刺激信号被给予电极1和2之前，每个刺激信号在预设时间周期内被给予。因此，如步骤112中所阐明的，启动计时器来识别第一脉冲周期的开始。然后确定预设时间是否已经过去(114)，此时重复步骤111到114。
虽然已经参考一些实施例描述了本发明，但是可以理解，可以在权利要求的范围内作出变化和修改。这样的修改可以包括替换元件或组件，其以基本上相同的方式执行基本上相同的功能以实现基本上相同的结果，而本发明在权利要求范围内通过修改可以得以实践。

Claims (19)

1、一种消化器官刺激器，包括：
刺激信号发生器；
信号选择器，耦合至所述信号发生器并被配置成随机或伪随机地选择至少一个信号参数；以及
刺激输出，被配置成耦合至消化器官，其中，所述刺激发生器被配置成通过所述刺激输出，输出包括至少一个所选信号参数的刺激信号。
2、权利要求1所述的消化器官刺激器，其中，所述信号选择器包括伪随机信号选择器，其被配置成伪随机地选择所述至少一个信号参数。
3、权利要求1所述的消化器官刺激器，其中，所述至少一个所选信号参数是从包括下列参数的组中选择的：脉冲宽度、脉冲重复率、脉冲串频率和脉冲串重复率。
4、权利要求1所述的消化器官刺激器，其中，所述至少一个所选信号参数是从信号参数的预定组中选择的。
5、权利要求1所述的消化器官刺激器，还包括：
多个输出，其中，所述信号选择器被配置成选择将给予其的所述多个输出的每一个的信号参数。
6、权利要求1所述的设备，其中，所述信号选择器被配置成选择多个参数类型的每一个的参数。
7、权利要求1所述的设备，其中，所述刺激输出包括电极。
8、权利要求1所述的设备，其中，所述刺激输出包括被配置成耦合至胃肠道的电极。
9、权利要求1所述的设备，其中，所述刺激输出包括被配置成耦合至胃的电极。
10、权利要求1所述的设备，还包括传感器，被配置成感测对于器官刺激的响应，其中，所述传感器耦合至信号选择器，其中，信号选择器被配置成当传感器没有感测到对于刺激的适当响应时，随机或伪随机地选择新的参数。
11、一种刺激消化器官的方法，包括步骤：
提供电耦合至消化器官的刺激器；
随机或伪随机地选择用于消化器官的刺激的参数；以及
给予消化器官包括所选参数的刺激信号。
12、权利要求11所述的方法，其中，选择参数的步骤包括：伪随机地选择参数。
13、权利要求12所述的方法，其中，选择参数的步骤包括：产生对应于参数的随机数，并基于所述随机数来确定随机参数。
14、权利要求11所述的方法，其中，选择参数的步骤包括：随机地选择参数窗口内的参数。
15、权利要求11所述的方法，其中，选择参数的步骤包括：从第一类型的参数中选择第一参数和从第二类型的参数中选择第二参数；以及
其中，给予刺激信号的步骤包括：给予消化器官包括第一参数和第二参数的刺激信号。
16、权利要求11所述的方法，还包括步骤：
感测消化器官对于刺激信号的响应；
确定消化器官的响应是否处于期望范围内；以及
如果消化器官的响应不处于期望范围内，则随机或伪随机地选择新的参数。
17、权利要求11所述的方法，给予消化器官刺激信号的步骤包括：向胃肠道的一部分给予所述信号。
18、权利要求17所述的方法，其中，给予胃肠道所述信号的步骤包括：向胃给予信号以产生过饱的感觉。
19、权利要求11所述的方法，
其中，提供电耦合至消化器官的刺激器的步骤包括：提供电耦合至消化器官的多个点的刺激器；
其中，选择用于消化器官的刺激的参数的步骤包括：随机或伪随机地选择用于多个点的每一个处的刺激的独立参数；以及
其中，给予消化器官包括参数的刺激信号的步骤包括：给予包括用于多个点的每一个的独立参数的刺激信号，其中，一个点处的每个独立参数是与给予所述多个点的其它点的其它独立参数无关地选择的。
CNA2006800384664A 2005-09-01 2006-08-31 肠胃器官的随机刺激 Pending CN101495173A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/219,004 US7616996B2 (en) 2005-09-01 2005-09-01 Randomized stimulation of a gastrointestinal organ
US11/219,004 2005-09-01

Publications (1)

Publication Number Publication Date
CN101495173A true CN101495173A (zh) 2009-07-29

Family

ID=37805333

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800384664A Pending CN101495173A (zh) 2005-09-01 2006-08-31 肠胃器官的随机刺激

Country Status (6)

Country Link
US (2) US7616996B2 (zh)
EP (1) EP1928544A4 (zh)
CN (1) CN101495173A (zh)
AU (1) AU2006284771B2 (zh)
CA (1) CA2621212A1 (zh)
WO (1) WO2007027875A2 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921263A (zh) * 2015-06-28 2018-04-17 亚龙·伊兰 胃肠道刺激装置及其用途
CN109350825A (zh) * 2018-10-25 2019-02-19 浙江工业大学 一种基于期望误差原理的电刺激警醒方法
CN109675171A (zh) * 2019-03-04 2019-04-26 中国科学院深圳先进技术研究院 动物刺激方法、装置、设备和存储介质

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7643887B2 (en) * 2001-05-01 2010-01-05 Intrapace, Inc. Abdominally implanted stimulator and method
US6535764B2 (en) * 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US7747322B2 (en) 2001-05-01 2010-06-29 Intrapace, Inc. Digestive organ retention device
US7689284B2 (en) * 2001-05-01 2010-03-30 Intrapace, Inc. Pseudounipolar lead for stimulating a digestive organ
US7979127B2 (en) 2001-05-01 2011-07-12 Intrapace, Inc. Digestive organ retention device
US7616996B2 (en) 2005-09-01 2009-11-10 Intrapace, Inc. Randomized stimulation of a gastrointestinal organ
AU2010308498B2 (en) 2009-10-21 2016-02-11 Apollo Endosurgery, Inc. Bariatric device and method for weight loss
CA2793367C (en) 2010-03-15 2018-01-02 Allergan, Inc. Bariatric device and method for weight loss
US9463107B2 (en) 2010-10-18 2016-10-11 Apollo Endosurgery, Inc. Variable size intragastric implant devices
WO2012054519A2 (en) 2010-10-18 2012-04-26 Allergan, Inc. Reactive intragastric implant devices
US9233016B2 (en) 2010-10-18 2016-01-12 Apollo Endosurgery, Inc. Elevating stomach stimulation device
US8870966B2 (en) 2010-10-18 2014-10-28 Apollo Endosurgery, Inc. Intragastric balloon for treating obesity
ES2566498T3 (es) 2010-10-18 2016-04-13 Apollo Endosurgery, Inc. Implantes intragástricos con anclajes duodenales
US9095405B2 (en) 2010-10-19 2015-08-04 Apollo Endosurgery, Inc. Space-filling intragastric implants with fluid flow
US9198790B2 (en) 2010-10-19 2015-12-01 Apollo Endosurgery, Inc. Upper stomach gastric implants
US8864840B2 (en) 2010-10-19 2014-10-21 Apollo Endosurgery, Inc. Intragastric implants with collapsible frames
ES2593753T3 (es) 2010-10-19 2016-12-13 Apollo Endosurgery, Inc. Manga duodenal con anclaje sin perforación
US9398969B2 (en) 2010-10-19 2016-07-26 Apollo Endosurgery, Inc. Upper stomach gastric implants
US8920447B2 (en) 2010-10-19 2014-12-30 Apollo Endosurgery, Inc. Articulated gastric implant clip
US9498365B2 (en) 2010-10-19 2016-11-22 Apollo Endosurgery, Inc. Intragastric implants with multiple fluid chambers
US10376399B2 (en) 2013-09-29 2019-08-13 Institut Hospitalo-Universitaire De Chirurgie Mini-Invasive Guidee Par L'image Implantable device to treat obesity
US10376145B2 (en) 2015-02-24 2019-08-13 Elira, Inc. Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch
US10335302B2 (en) 2015-02-24 2019-07-02 Elira, Inc. Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions
US9956393B2 (en) 2015-02-24 2018-05-01 Elira, Inc. Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch
US10864367B2 (en) 2015-02-24 2020-12-15 Elira, Inc. Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions
WO2016138176A1 (en) 2015-02-24 2016-09-01 Elira Therapeutics Llc Systems and methods for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch
US10765863B2 (en) 2015-02-24 2020-09-08 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
EP3416719A4 (en) 2016-02-19 2019-12-11 Nalu Medical, Inc. APPARATUS HAVING IMPROVED STIMULATION WAVEFORMS
CN105832440B (zh) * 2016-05-11 2017-10-13 深圳市和拓网络科技有限公司 一种伪随机振幅可调口腔声波震动清洁装置
WO2018017463A1 (en) 2016-07-18 2018-01-25 Nalu Medical, Inc. Methods and systems for treating pelvic disorders and pain conditions
EP3585475B1 (en) 2017-02-24 2024-04-03 Nalu Medical, Inc. Apparatus with sequentially implanted stimulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030135248A1 (en) * 2002-01-11 2003-07-17 Medtronic, Inc. Variation of neural-stimulation parameters
US20050131485A1 (en) * 2003-02-03 2005-06-16 Enteromedics, Inc. High frequency vagal blockage therapy

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3411507A (en) 1964-04-01 1968-11-19 Medtronic Inc Method of gastrointestinal stimulation with electrical pulses
US3662758A (en) 1969-06-30 1972-05-16 Mentor Corp Stimulator apparatus for muscular organs with external transmitter and implantable receiver
US3646940A (en) 1969-07-15 1972-03-07 Univ Minnesota Implantable electronic stimulator electrode and method
US3677251A (en) 1970-03-10 1972-07-18 Gen Electric Body organ stimulator with interference rejector
US3835865A (en) 1970-07-10 1974-09-17 Gen Electric Body organ stimulator
USRE30366E (en) 1970-09-21 1980-08-12 Rasor Associates, Inc. Organ stimulator
US3735766A (en) 1971-04-19 1973-05-29 Gen Electric Optional unipolar-bipolar body organ stimulator
US3796221A (en) 1971-07-07 1974-03-12 N Hagfors Apparatus for delivering electrical stimulation energy to body-implanted apparatus with signal-receiving means
US3815611A (en) 1971-11-26 1974-06-11 Medtronic Inc Muscle stimulation and/or contraction detection device
US4135518A (en) 1976-05-21 1979-01-23 Medtronic, Inc. Body implantable lead and electrode
US4102344A (en) 1976-11-15 1978-07-25 Mentor Corporation Stimulator apparatus for internal body organ
US4153059A (en) * 1977-10-25 1979-05-08 Minnesota Mining And Manufacturing Company Urinary incontinence stimulator system
JPS54119792A (en) * 1978-03-03 1979-09-17 Iriyou Kougaku Kenkiyuushiyo K Electric stimulation device for removing pain
US4431000A (en) * 1978-11-29 1984-02-14 Gatron Corporation Transcutaneous nerve stimulator with pseusorandom pulse generator
US4628928A (en) 1982-08-09 1986-12-16 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
AU2883784A (en) 1983-06-15 1984-12-20 Medtronic, Inc. Organ capture detection for electrical stimulators
US4571556A (en) * 1983-07-28 1986-02-18 Mi Medical & Scientific Instruments, Inc. Randomized-clock circuit
US4690145A (en) * 1985-06-17 1987-09-01 Minnesota Mining And Manufacturing Company Output limited electrical stimulator for biological tissue
US4699143A (en) * 1985-06-17 1987-10-13 Minnesota Mining And Manufacturing Company Electrical simulator for biological tissue having remote control
US4688574A (en) * 1985-06-17 1987-08-25 Minnesota Mining And Manufacturing Company Electrical stimulator for biological tissue having mode control
US4823808A (en) 1987-07-06 1989-04-25 Clegg Charles T Method for control of obesity, overweight and eating disorders
US4921481A (en) 1988-03-23 1990-05-01 Abbott Laboratories Enteral feeding system utilizing gastrointestinal myoelectrography
US4925446A (en) 1988-07-06 1990-05-15 Transpharm Group Inc. Removable inflatable intragastrointestinal device for delivering beneficial agents
US5411527A (en) 1989-05-03 1995-05-02 Intermedics, Inc. Difibrillation electrodes and implantation
US5111816A (en) 1989-05-23 1992-05-12 Ventritex System configuration for combined defibrillator/pacemaker
US5681260A (en) 1989-09-22 1997-10-28 Olympus Optical Co., Ltd. Guiding apparatus for guiding an insertable body within an inspected object
ATE160290T1 (de) * 1990-05-26 1997-12-15 Med El Medical Electronics Ele Einrichtung zur neuromuskulären elektroreizung
US5197491A (en) 1990-09-28 1993-03-30 Brunswick Biomedical Technologies, Inc. Esophageal-stomach displacement electrode
US5217449A (en) 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5188104A (en) 1991-02-01 1993-02-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5112310A (en) * 1991-02-06 1992-05-12 Grobe James L Apparatus and methods for percutaneous endoscopic gastrostomy
US5259399A (en) 1992-03-02 1993-11-09 Alan Brown Device and method of causing weight loss using removable variable volume intragastric bladder
IT1260485B (it) 1992-05-29 1996-04-09 Procedimento e dispositivo per il trattamento dell'obesita' di un paziente
US5292344A (en) 1992-07-10 1994-03-08 Douglas Donald D Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port
US5248302A (en) 1992-08-05 1993-09-28 Biosearch Medical Products Inc. Percutaneous obturatable internal anchoring device
US5415181A (en) 1993-12-01 1995-05-16 The Johns Hopkins University AM/FM multi-channel implantable/ingestible biomedical monitoring telemetry system
EP0672427A1 (en) 1994-03-17 1995-09-20 Siemens-Elema AB System for infusion of medicine into the body of a patient
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
ES2233239T3 (es) 1995-06-23 2005-06-16 Gyrus Medical Limited Instrumento electroquirurgico.
US5800445A (en) 1995-10-20 1998-09-01 United States Surgical Corporation Tissue tagging device
US5716392A (en) 1996-01-05 1998-02-10 Medtronic, Inc. Minimally invasive medical electrical lead
WO1997027829A1 (en) 1996-01-31 1997-08-07 The Trustees Of The University Of Pennsylvania Remote control drug delivery device
WO1997036646A1 (fr) 1996-04-01 1997-10-09 Valery Ivanovich Kobozev Stimulateur electrique des voies gastro-intestinales
US5690691A (en) * 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
US5792048A (en) 1996-09-03 1998-08-11 Schaefer; Guenter Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners
AU4107297A (en) 1996-09-05 1998-03-26 Governors Of The University Of Alberta, The Gastro-intestinal electrical pacemaker
US5935107A (en) 1996-10-07 1999-08-10 Applied Medical Resources Corporation Apparatus and method for surgically accessing a body cavity
US6026326A (en) 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
US5836994A (en) 1997-04-30 1998-11-17 Medtronic, Inc. Method and apparatus for electrical stimulation of the gastrointestinal tract
US5861014A (en) 1997-04-30 1999-01-19 Medtronic, Inc. Method and apparatus for sensing a stimulating gastrointestinal tract on-demand
US6216039B1 (en) 1997-05-02 2001-04-10 Medtronic Inc. Method and apparatus for treating irregular gastric rhythms
IT1292016B1 (it) 1997-05-28 1999-01-25 Valerio Cigaina Dispositivo di impianto particolarmente per elettrostimolazione e/o elettroregistrazione di visceri endoaddominali
US6381495B1 (en) 1997-05-28 2002-04-30 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US6477423B1 (en) 1997-05-28 2002-11-05 Transneuronix, Inc. Medical device for use in laparoscopic surgery
US6321124B1 (en) 1997-05-28 2001-11-20 Transneuronix, Inc. Implant device for electrostimulation and/or monitoring of endo-abdominal cavity tissue
EP1779890B8 (en) * 1997-07-16 2009-07-08 Metacure Limited Smooth muscle controller
US6479523B1 (en) 1997-08-26 2002-11-12 Emory University Pharmacologic drug combination in vagal-induced asystole
US6030364A (en) * 1997-10-03 2000-02-29 Boston Scientific Corporation Apparatus and method for percutaneous placement of gastro-intestinal tubes
US5993473A (en) 1997-11-19 1999-11-30 Chan; Yung C. Expandable body device for the gastric cavity and method
DE69830295T2 (de) * 1997-11-27 2005-10-13 Matsushita Electric Industrial Co., Ltd., Kadoma Steuerungsverfahren
US6104955A (en) 1997-12-15 2000-08-15 Medtronic, Inc. Method and apparatus for electrical stimulation of the gastrointestinal tract
US6091992A (en) 1997-12-15 2000-07-18 Medtronic, Inc. Method and apparatus for electrical stimulation of the gastrointestinal tract
AU2492699A (en) * 1998-02-02 1999-08-16 Trustees Of Columbia University In The City Of New York, The Electrical system for weight loss and laparoscopic implantation thereof
US5902331A (en) * 1998-03-10 1999-05-11 Medtronic, Inc. Arrangement for implanting an endocardial cardiac lead
US20050038454A1 (en) * 1998-05-29 2005-02-17 By-Pass, Inc. Anastomotic delivery system
US6112123A (en) 1998-07-28 2000-08-29 Endonetics, Inc. Device and method for ablation of tissue
US6366814B1 (en) 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US20050137644A1 (en) * 1998-10-26 2005-06-23 Boveja Birinder R. Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders
US6611715B1 (en) 1998-10-26 2003-08-26 Birinder R. Boveja Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator
US6205359B1 (en) 1998-10-26 2001-03-20 Birinder Bob Boveja Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator
US7076307B2 (en) * 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
US6097984A (en) 1998-11-25 2000-08-01 Medtronic, Inc. System and method of stimulation for treating gastro-esophageal reflux disease
US6427089B1 (en) 1999-02-19 2002-07-30 Edward W. Knowlton Stomach treatment apparatus and method
US6098629A (en) 1999-04-07 2000-08-08 Endonetics, Inc. Submucosal esophageal bulking device
US6285897B1 (en) 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
CA2366760A1 (en) 1999-04-07 2000-10-12 John T. Kilcoyne Implantable monitoring probe
US6606523B1 (en) 1999-04-14 2003-08-12 Transneuronix Inc. Gastric stimulator apparatus and method for installing
US6684104B2 (en) 1999-04-14 2004-01-27 Transneuronix, Inc. Gastric stimulator apparatus and method for installing
US6542776B1 (en) 1999-04-14 2003-04-01 Transneuronix Inc. Gastric stimulator apparatus and method for installing
US6895278B1 (en) * 1999-04-14 2005-05-17 Transneuronix, Inc. Gastric stimulator apparatus and method for use
IT1313608B1 (it) 1999-08-06 2002-09-09 Valerio Cigaina Apparecchiatura per la stimolazione di uno stato di continenzacompleta del neosfintere nella confezione di neostomie continenti e
US6510332B1 (en) 1999-08-30 2003-01-21 Transneuronix, Inc. Electrode leads for use in laparoscopic surgery
IL133592A0 (en) 1999-12-19 2001-04-30 Impulse Dynamics Ltd Fluid phase electrode lead
US6600953B2 (en) 2000-12-11 2003-07-29 Impulse Dynamics N.V. Acute and chronic electrical signal therapy for obesity
MXPA00001922A (es) 2000-02-24 2002-03-08 De Hayos Garza Andres Cateter de balon intragastrico percutaneo para tratamiento de la obesidad.
US6826428B1 (en) 2000-04-11 2004-11-30 The Board Of Regents Of The University Of Texas System Gastrointestinal electrical stimulation
US6540789B1 (en) 2000-06-15 2003-04-01 Scimed Life Systems, Inc. Method for treating morbid obesity
US6895279B2 (en) 2000-09-15 2005-05-17 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to treat disorders of gastrointestinal peristalsis
US20020072780A1 (en) 2000-09-26 2002-06-13 Transneuronix, Inc. Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity
US7033373B2 (en) * 2000-11-03 2006-04-25 Satiety, Inc. Method and device for use in minimally invasive placement of space-occupying intragastric devices
US6591137B1 (en) 2000-11-09 2003-07-08 Neuropace, Inc. Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders
US6615084B1 (en) 2000-11-15 2003-09-02 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
US6609025B2 (en) 2001-01-02 2003-08-19 Cyberonics, Inc. Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation
EP1357971B1 (en) 2001-01-05 2015-05-20 Metacure Limited Regulation of eating habits
US6952613B2 (en) 2001-01-31 2005-10-04 Medtronic, Inc. Implantable gastrointestinal lead with active fixation
US6876885B2 (en) 2001-01-31 2005-04-05 Medtronic, Inc. Implantable bifurcated gastrointestinal lead with active fixation
US6754536B2 (en) 2001-01-31 2004-06-22 Medtronic, Inc Implantable medical device affixed internally within the gastrointestinal tract
US6775573B2 (en) 2001-03-01 2004-08-10 Science Medicus Inc. Electrical method to control autonomic nerve stimulation of gastrointestinal tract
US7330753B2 (en) 2001-04-18 2008-02-12 Metacure N.V. Analysis of eating habits
US20050143784A1 (en) * 2001-05-01 2005-06-30 Imran Mir A. Gastrointestinal anchor with optimal surface area
US7747322B2 (en) * 2001-05-01 2010-06-29 Intrapace, Inc. Digestive organ retention device
US7616996B2 (en) 2005-09-01 2009-11-10 Intrapace, Inc. Randomized stimulation of a gastrointestinal organ
US7689284B2 (en) * 2001-05-01 2010-03-30 Intrapace, Inc. Pseudounipolar lead for stimulating a digestive organ
US7643887B2 (en) * 2001-05-01 2010-01-05 Intrapace, Inc. Abdominally implanted stimulator and method
US6535764B2 (en) 2001-05-01 2003-03-18 Intrapace, Inc. Gastric treatment and diagnosis device and method
US7702394B2 (en) * 2001-05-01 2010-04-20 Intrapace, Inc. Responsive gastric stimulator
US7054692B1 (en) 2001-06-22 2006-05-30 Advanced Bionics Corporation Fixation device for implantable microdevices
US20060116736A1 (en) * 2001-07-23 2006-06-01 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of obesity
US6999819B2 (en) 2001-08-31 2006-02-14 Medtronic, Inc. Implantable medical electrical stimulation lead fixation method and apparatus
US20030120328A1 (en) 2001-12-21 2003-06-26 Transneuronix, Inc. Medical implant device for electrostimulation using discrete micro-electrodes
US20030144708A1 (en) 2002-01-29 2003-07-31 Starkebaum Warren L. Methods and apparatus for retarding stomach emptying for treatment of eating disorders
JP4351458B2 (ja) * 2002-03-18 2009-10-28 オリンパス株式会社 内視鏡挿入システム
US7689276B2 (en) * 2002-09-13 2010-03-30 Leptos Biomedical, Inc. Dynamic nerve stimulation for treatment of disorders
DE10214002A1 (de) * 2002-03-27 2003-10-09 Roehm Gmbh Pharmazeutische Formulierung für den Wirkstoff Budesonid
US7463934B2 (en) 2002-04-12 2008-12-09 Medtronic, Inc. Implantable medical device with captivation fixation
US20040015201A1 (en) 2002-04-22 2004-01-22 Transneuronix, Inc. Process for electrostimulation treatment of obesity
US7020526B1 (en) 2002-05-16 2006-03-28 Ruan Jin Zhao Electronic gastro-intestinal stimulation device
US7338444B2 (en) * 2002-06-28 2008-03-04 Oridion Breathid Ltd Management of gastro-intestinal disorders
US20040088022A1 (en) 2002-07-26 2004-05-06 Transneuronix, Inc. Process for electrostimulation treatment of morbid obesity
AU2003284951A1 (en) 2002-10-25 2004-05-13 Raphael Schumert Gastrointestinal pacemaker
US7033146B2 (en) * 2003-01-08 2006-04-25 Assoma Inc. Sealed magnetic drive sealless pump
US7167750B2 (en) 2003-02-03 2007-01-23 Enteromedics, Inc. Obesity treatment with electrically induced vagal down regulation
US20040172084A1 (en) 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US20060074450A1 (en) * 2003-05-11 2006-04-06 Boveja Birinder R System for providing electrical pulses to nerve and/or muscle using an implanted stimulator
US7742818B2 (en) 2003-05-19 2010-06-22 Medtronic, Inc. Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
US7620454B2 (en) 2003-05-19 2009-11-17 Medtronic, Inc. Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof
US9498366B2 (en) * 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US7263405B2 (en) * 2003-08-27 2007-08-28 Neuro And Cardiac Technologies Llc System and method for providing electrical pulses to the vagus nerve(s) to provide therapy for obesity, eating disorders, neurological and neuropsychiatric disorders with a stimulator, comprising bi-directional communication and network capabilities
US7054690B2 (en) * 2003-10-22 2006-05-30 Intrapace, Inc. Gastrointestinal stimulation device
US20050096514A1 (en) * 2003-11-01 2005-05-05 Medtronic, Inc. Gastric activity notification
WO2005051486A1 (en) * 2003-11-28 2005-06-09 University Technologies International Inc. Method and apparatus for gastrointestinal motility control
US20050149142A1 (en) * 2004-01-07 2005-07-07 Starkebaum Warren L. Gastric stimulation responsive to sensing feedback
US7177693B2 (en) * 2004-01-07 2007-02-13 Medtronic, Inc. Gastric stimulation for altered perception to treat obesity
US20050159801A1 (en) * 2004-01-16 2005-07-21 Medtronic, Inc. Novel implantable lead including sensor
US7286884B2 (en) * 2004-01-16 2007-10-23 Medtronic, Inc. Implantable lead including sensor
WO2005089646A1 (en) * 2004-03-16 2005-09-29 Medtronic, Inc. Sensitivity analysis for selecting therapy parameter sets
WO2006049725A2 (en) * 2004-03-23 2006-05-11 Minimus Surgical Systems Surgical systems and devices to enhance gastric restriction therapies
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US20050222638A1 (en) 2004-03-30 2005-10-06 Steve Foley Sensor based gastrointestinal electrical stimulation for the treatment of obesity or motility disorders
US20050222637A1 (en) 2004-03-30 2005-10-06 Transneuronix, Inc. Tachygastrial electrical stimulation
US7127295B2 (en) 2004-05-05 2006-10-24 Evans John R Device and method for placement of electrodes in the GI tract
US7664551B2 (en) * 2004-07-07 2010-02-16 Medtronic Transneuronix, Inc. Treatment of the autonomic nervous system
US20060020298A1 (en) * 2004-07-20 2006-01-26 Camilleri Michael L Systems and methods for curbing appetite
US8452407B2 (en) * 2004-08-16 2013-05-28 Boston Scientific Neuromodulation Corporation Methods for treating gastrointestinal disorders
EP1796568A1 (en) * 2004-09-09 2007-06-20 Vnus Medical Technologies, Inc. Methods and apparatus for treatment of hollow anatomical structures
US7593777B2 (en) * 2004-10-26 2009-09-22 Medtronic, Inc. Fixation of a medical implant to the exterior of a body organ
US8489189B2 (en) * 2004-10-29 2013-07-16 Medtronic, Inc. Expandable fixation mechanism
WO2007032854A1 (en) 2005-08-19 2007-03-22 Schering Corporation FUSED TRICYCLIC mGluR1 ANTAGONISTS AS THERAPEUTIC AGENTS
US7509175B2 (en) * 2006-08-03 2009-03-24 Intrapace, Inc. Method and devices for stimulation of an organ with the use of a transectionally placed guide wire

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030135248A1 (en) * 2002-01-11 2003-07-17 Medtronic, Inc. Variation of neural-stimulation parameters
US20050131485A1 (en) * 2003-02-03 2005-06-16 Enteromedics, Inc. High frequency vagal blockage therapy

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921263A (zh) * 2015-06-28 2018-04-17 亚龙·伊兰 胃肠道刺激装置及其用途
US11116658B2 (en) 2015-06-28 2021-09-14 Oberon Sciences Ilan Ltd. Devices for gastrointestinal stimulation and uses thereof
CN109350825A (zh) * 2018-10-25 2019-02-19 浙江工业大学 一种基于期望误差原理的电刺激警醒方法
CN109675171A (zh) * 2019-03-04 2019-04-26 中国科学院深圳先进技术研究院 动物刺激方法、装置、设备和存储介质

Also Published As

Publication number Publication date
US7616996B2 (en) 2009-11-10
US20070049986A1 (en) 2007-03-01
WO2007027875A2 (en) 2007-03-08
CA2621212A1 (en) 2007-03-08
EP1928544A4 (en) 2011-06-01
AU2006284771A1 (en) 2007-03-08
US8032223B2 (en) 2011-10-04
WO2007027875A3 (en) 2009-04-23
AU2006284771B2 (en) 2011-03-31
EP1928544A2 (en) 2008-06-11
US20100023087A1 (en) 2010-01-28

Similar Documents

Publication Publication Date Title
CN101495173A (zh) 肠胃器官的随机刺激
US6622038B2 (en) Treatment of movement disorders by near-diaphragmatic nerve stimulation
WO2003090844A3 (en) Wave shaping for an implantable medical device
US8538547B2 (en) Apparatus for the stimulation of neural networks
US7310557B2 (en) Identification of electrodes for nerve stimulation in the treatment of eating disorders
US7899540B2 (en) Noninvasively adjustable gastric band
US7835796B2 (en) Weight loss method and device
JP2013530747A5 (zh)
CA2433376A1 (en) Treatment of obesity by sub-diaphragmatic nerve stimulation
JP2008512180A5 (zh)
ATE416819T1 (de) Programierbare wellenförmige pulse für ein implantierbares medizinisches gerät
IL145911A0 (en) Gastric stimulator apparatus and method for use
WO2007081764A3 (en) Electrical stimulation device and method for the treatment of dysphagia
EP3568196B1 (en) Patterned stimulation for deep brain stimulation
CA2401098A1 (en) Treatment of obesity by bilateral vagus nerve stimulation
US9566438B2 (en) Active implantable medical device for neural therapy with stochastic stimulation of the vagus nerve
JP4627958B2 (ja) パルス電気刺激装置
EP1537893A3 (en) Programmable gastric stimulator apparatus
WO2021151050A1 (en) Biomimetic stimulator system for neural implant
Jurkov et al. Implantable functional gastrointestinal neurostimulation

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20090729