CN101543641B - Calcium phosphate bone cement with hollow communicating structure - Google Patents
Calcium phosphate bone cement with hollow communicating structure Download PDFInfo
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- CN101543641B CN101543641B CN 200810157832 CN200810157832A CN101543641B CN 101543641 B CN101543641 B CN 101543641B CN 200810157832 CN200810157832 CN 200810157832 CN 200810157832 A CN200810157832 A CN 200810157832A CN 101543641 B CN101543641 B CN 101543641B
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- bone cement
- communicating structure
- hollow
- forming method
- powder
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Abstract
The invention relates to porous bone cement with a hollow communicating structure and a forming method thereof. The forming method comprises the following steps: oxydol is taken as a foaming agent under the condition of normal temperature, and alpha-phase tricalcium phosphate is mixed with HA powder, and a slip casting method is used for forming. Steel needles are inserted into a lengthwise position of a mould and rapidly pulled out after the initial set of materials so as to prepare porous alpha-TCP bone cement with a large-aperture hollow pipe structure. The forming method needs no complicated reaction reagent and high-temperature calcination condition, thereby not only having low cost and simple equipment but also having easy control of technological parameters; and in addition, the prepared porous alpha-TCP bone cement has the hollow communicating structure with larger dimension, thereby being beneficial to modifying bones.
Description
Technical field
The present invention relates to a kind of porous bone cement and forming method thereof that contains the hollow communicating structure, belong to bio-medical bone material technology.
Background technology
The present invention relates to the technology of preparing of bone cement hollow pipe.Since 1976 Hai Deqimanma (HidekiMonma) found the α tricalcium phosphate (since α-TCP) had the hydration and hardening characteristic, the various countries scholar carried out research widely to calcium phosphate bone cement.When in acid-base value 6<pH<8 scopes of calcium phosphate bone cement control aquation system, its hydrated product is HA, and HA is the main component of inorganic salt in people's osseous tissue, can participate in the metabolism of bone behind the implant into body, promote the growth of bone, and heat release is few in the calcium phosphate bone cement hydration process, it is little to heat up, can not cause hot-spot, thereby research and the application of calcium phosphate bone cement in the bone defective tissue developed fast.Though but the support that calcium phosphate bone cement is used as bone tissue engineer can form microcellular structure, the connection degree in aperture and hole does not all reach clinical requirement, and strength of materials deficiency.The hollow communicating structure can provide the three dimensions of depending on for existence for cell, is conducive to cell tactophily, the extracellular matrix precipitation, and nutrition and oxygen enter, and the metabolite discharge also helps blood vessel simultaneously and nerve is grown into, and is conducive to the reparation of bone.
Summary of the invention
In view of defective or deficiency that above-mentioned prior art exists, the object of the invention aims to provide a kind of fairly simple no method for calcinating and prepares hollow communicating structure bone cement material.Mainly be to utilize lime nitrate and diammonium phosphate to be raw material, adopt the hydrothermal Synthesis of Hydroxy Apatite powder body; With CaHPO
42H
2O and pure CaCO
3Powder evenly mixes by 2: 1 (mol), is fired to 1250 ℃, behind the insulation 1h in air chilling, obtain the tricalcium phosphate of α phase.Under room temperature (37 ℃) condition, in α-TCP powder, add the 6%HA powder, add 6% foaming agent (hydrogen peroxide) pore-forming then and insert draw point in the mould lengthwise position, use filling forming method, after material final set, extract draw point rapidly out, porous α-TCP bone cement that preparation has larger aperture (Ф is 0.9mm, and adjustable) hollow through tube structure.
The bone cement material internal that makes with the present invention has the hollow communicating structure of large-size, and the aperture is about 0.9mm (and adjustable), is conducive to growing into of osteocyte, and the pore size distribution range of other disperse pore is bigger, is beneficial to sticking of osteocyte.The present invention does not need complicated reaction reagent and high-temperature calcination condition, and not only cost is low, and equipment is simple, and technological parameter also is easy to control, is beneficial to the carrying out of bone reparation.
Description of drawings
Accompanying drawing is the SEM figure in whole pattern and cross section.Fig. 1 is hollow through tube outside drawing, and Fig. 2 is the scanning electron microscope (SEM) photograph of macropore in the material.
Specific embodiments 1
(1). quench prepares α-TCP
With analytically pure CaHPO
42H
2O and analytical pure CaCO
3Fine powder evenly mixes by 2: 1 (mol), be fired to 1250 ℃ then, the insulation 1h after in air chilling, can obtain the tricalcium phosphate (loose white powder solid) of α phase, the powder of firing put in the QM-35P2 type planetary ball mill grind, it is 720r/min that rotating speed is set, and grinds 4h, cross 250 mesh sieves, put it into then in the numbered sample sack for the experiment of back and use.
(2). hydro-thermal method is synthesized HA
28.10g lime nitrate and 9.24g diammonium phosphate are mixed in the distilled water that the 140mL pH value is 7.5 (regulating with ammonia); Simultaneously the lime nitrate of equivalent and diammonium phosphate are mixed in the 140mL pH value and are in 10.5 the distilled water, stir the 10min postprecipitation respectively.Be that the gained precipitate is scattered in the clear liquid that pH value is gained under 10.5 conditions under 7.5 conditions with pH value, mixed suspension is poured in the 100mL autoclave hydrothermal treatment consists 10h under 180 ℃ of conditions into again again.Be cooled to room temperature, precipitation, with distilled water with after the washing of precipitate 3 times under 80 ℃ of conditions dry 10h, the HA powder that obtains is put in the QM-35P2 type planetary ball mill and is ground, it is 720r/min that rotating speed is set, grind 4h, cross 250 mesh sieves, put it in the numbered sample sack experiment use for the back then.
(3). the HA powder that takes by weighing α-TCP powder adding 6% of 20.462 grams is put into ball grinder as crystal seed, and ball milling is four hours on the star ball mill.Cross in the bag of packing into behind 200 mesh sieves and seal, post label.
Get 12.121 gram powder, the hydrogen peroxide of adding 6% adds distilled water as foaming agent with pipet, adds about 0.40ml distilled water in every gram powder, transfers the viscosity of powder as toothpaste.(Ф is that the 0.9mm draw point vertically inserts mould to pour mould behind the mix homogeneously into, and making draw point extract easily) after shock is flat, drives bubble away, and sample is put into container, placing temperature is in 37 ℃ the water-bath, and with preservative film sealing, surveying its presetting period is 21min, and final setting time is 45min, when 50min, draw point is extracted, sample is incubated 24h in water-bath, the demoulding then makes and contains the porous bone cement that diameter is 0.9mm hollow communicating structure.
Specific embodiments 2
Be the mould of hollow pipe except the draw point that is 5mm in (3) step with Ф in the step of embodiment 2 and the scheme 1, other step is identical, and the hollow pipe diameter of the porous bone cement that contains the hollow communicating structure of acquisition is 5mm.
Claims (2)
1. porous bone cement forming method that contains the hollow communicating structure, it is characterized in that type alpha tricalcium phosphate is mixed by mass ratio with hydroxylapatite powder at 16: 1, namely obtain the powder of preparation bone cement, with powder and hydrogen peroxide by the solid-liquid mass ratio be mix at 16: 1 after, mix with an amount of water again, in mould, make the bone cement material of communicating structure.
2. the porous bone cement forming method that contains the hollow communicating structure according to claim 1 makes the bone cement material of communicating structure, it is characterized in that the bone cement material internal has the hollow communicating structure, it is the used draw point diameter of mould that hollow connects the aperture, and the pore size distribution range of other disperse pore is bigger.
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CN 200810157832 CN101543641B (en) | 2008-10-15 | 2008-10-15 | Calcium phosphate bone cement with hollow communicating structure |
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CN 200810157832 CN101543641B (en) | 2008-10-15 | 2008-10-15 | Calcium phosphate bone cement with hollow communicating structure |
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CN101543641B true CN101543641B (en) | 2013-07-10 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612053A (en) * | 1983-10-06 | 1986-09-16 | American Dental Association Health Foundation | Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements |
CN1313132A (en) * | 2000-03-14 | 2001-09-19 | 瑞安大药厂股份有限公司 | Two-phase alpha-tricalcium phosphate/oxyhydrogen-base apatite bone cement and its preparing process |
CN1488680A (en) * | 2003-07-28 | 2004-04-14 | 浙江大学 | Calcium phosphate composite powder and preparing method thereof |
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2008
- 2008-10-15 CN CN 200810157832 patent/CN101543641B/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612053A (en) * | 1983-10-06 | 1986-09-16 | American Dental Association Health Foundation | Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements |
CN1313132A (en) * | 2000-03-14 | 2001-09-19 | 瑞安大药厂股份有限公司 | Two-phase alpha-tricalcium phosphate/oxyhydrogen-base apatite bone cement and its preparing process |
CN1488680A (en) * | 2003-07-28 | 2004-04-14 | 浙江大学 | Calcium phosphate composite powder and preparing method thereof |
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