CN101583323A - 用于对体腔进行非连续周缘治疗的方法和装置 - Google Patents

用于对体腔进行非连续周缘治疗的方法和装置 Download PDF

Info

Publication number
CN101583323A
CN101583323A CNA2007800496467A CN200780049646A CN101583323A CN 101583323 A CN101583323 A CN 101583323A CN A2007800496467 A CNA2007800496467 A CN A2007800496467A CN 200780049646 A CN200780049646 A CN 200780049646A CN 101583323 A CN101583323 A CN 101583323A
Authority
CN
China
Prior art keywords
energy transfer
transfer element
body cavity
energy
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2007800496467A
Other languages
English (en)
Other versions
CN101583323B (zh
Inventor
丹尼斯·德马雷
汉森·吉福德
尼古拉斯·扎德诺
马克·迪姆
本杰明·J·克拉克
安德鲁·吴
肯尼斯·J·米希里奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Ardian LLC
Original Assignee
Ardian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39402459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101583323(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardian Inc filed Critical Ardian Inc
Priority to CN201210069381.XA priority Critical patent/CN102847230B/zh
Publication of CN101583323A publication Critical patent/CN101583323A/zh
Application granted granted Critical
Publication of CN101583323B publication Critical patent/CN101583323B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00059—Material properties
    • A61B2018/00071—Electrical conductivity
    • A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/0016—Energy applicators arranged in a two- or three dimensional array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267—Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00404—Blood vessels other than those in or around the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505—Urinary tract
    • A61B2018/00511—Kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • A61B2018/00648—Sensing and controlling the application of energy with feedback, i.e. closed loop control using more than one sensed parameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00875—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/124—Generators therefor switching the output to different electrodes, e.g. sequentially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1435—Spiral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1465—Deformable electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N7/022—Localised ultrasound hyperthermia intracavitary

Abstract

本发明提供了用于体腔的不连续周缘治疗的方法和装置。装置可以被安置在患者的体腔内，并且可以在第一纵向和有角度的位置传递能量，以在第一位置产生小于完全周缘的治疗区。所述装置还可以在体腔内的一个或多个另外的纵向和有角度的位置传递能量，以在一个或多个另外的位置产生一个或多个小于完全周缘的治疗区，所述一个或多个另外的位置纵向地并且有角度地从所述第一治疗区偏置。所述第一治疗区和所述一个或多个另外的治疗区的叠置限定了没有连续周缘损害形成的不连续周缘治疗区。本发明提供了用于实现这种不连续周缘治疗的方法和装置的各种实施方案。

Description

用于对体腔进行非连续周缘治疗的方法和装置
相关申请的引用
本申请要求下列共同未决的美国专利申请的每一项的优先权：
(1)在2006年11月14日提交的美国专利申请11/599,890。
(2)在2005年5月13日提交的美国专利申请11/129,765，所述美国专利申请11/129,765(a)要求在2004年10月5日提交的美国临时专利申请60/616,254以及在2004年11月2日提交的60/624,793的权益；并且(b)是在2003年4月8日提交的美国专利申请10/408,665的部分继续申请，所述美国专利申请10/408,665要求在2002年4月8日提交的美国临时申请60/370,190、在2002年10月3日提交的60/415,575以及在2003年1月29日提交的60/442,970的权益。
(3)在2005年7月25日提交的美国专利申请11/189,563，所述美国专利申请11/189,563(a)是在2005年5月13日提交的美国专利申请11/129,765的部分继续申请，所述美国专利申请11/129,765要求在2004年10月5日提交的美国临时专利申请60/616,254以及在2004年11月2日提交的60/624,793的权益；并且(b)是在2004年7月28日提交的美国专利申请10/900,199(现在为美国专利6,978,174)的部分继续申请，所述美国专利申请10/900,199是2003年4月8日提交的美国专利申请10/408,665的部分继续申请，美国专利申请10/408,665要求在2002年4月8日提交的美国临时申请60/370,190、在2002年10月3日提交的60/415,575以及在2003年1月29日提交的60/442,970的权益。
所有的上述申请和专利通过引用而以全文形式结合在此。
通过引用的结合
本说明书中提及的所有出版物和专利申请都通过引用而结合在此，达到就像具体并单独地指出将每一个单独的出版物或专利申请通过引用而结合一样的程度。
技术领域
本发明涉及用于进行体腔内非连续周缘治疗的方法和装置。这种方法和装置的几个实施方案旨在体腔的周缘治疗，所述体腔的周缘治疗在一个或多个离散的治疗区域中施加能量，以形成一个或多个损害，所述一个或多个损害在垂直于体腔的纵轴的横截面的任何完全的周缘周围不接触或连续。
背景
本申请人已经描述了这样的方法和装置，所述方法和装置通过调节有助于肾功能的神经纤维，例如将含有有助于肾功能的神经纤维的组织去神经支配，从而治疗多种肾和心-肾疾病，例如心力衰竭、肾疾病、肾衰竭、高血压、造影剂肾病、心房纤维性颤动和心肌梗死。这预期降低肾交感神经活性，其增加了水和钠从身体的移去，并且使肾素分泌返回到更加正常的水平。正常化的肾素分泌引起供应肾的血管呈现出稳定的扩张/收缩的状态水平，这提供了适当的肾血流量。参见，例如，本申请人的共同未决美国专利申请：(a)在2003年4月8日提交的10/408,665；(b)在2005年5月13日提交的11/129,765；(c)在2005年7月25日提交的11/189,563；(d)在2006年2月27日提交的11/363,867；(e)在2006年8月14日提交的11/504,117；以及美国专利6,978,174。所有的这些申请和专利都通过引用而以全文形式结合在此。
本申请人之前还描述了这样的方法和装置，所述方法和装置用于患者内的神经支配血管或接近血管的任何靶神经纤维的血管内-诱导神经调节或去神经支配，例如用于治疗任何神经障碍或其它的医学病症。接近血管的神经可能使效应器官或组织受神经支配。血管内-诱导神经调节或去神经支配可以用于治疗多种神经障碍或其它的医学病症，所述神经障碍或其它的医学病症包括但不限于：包括心力衰竭和高血压的上述病症，以及疼痛和外围动脉闭塞病(例如，经由疼痛缓解)。该方法和装置可以用于调节传出或传入神经信号，以及传出和传入神经信号的组合。参见，例如，在2006年11月14日提交的题目为用于血管内-诱导神经调节或去神经支配的方法和装置(Methods and Apparatus for Intravascularly-Induced Neuromodulationor Denervation)(代理人备案号57856.8018.US)的本申请人的共同未决美国专利申请11/599,649，所述专利申请通过引用而以全文形式结合在此。
尽管上述方法本身是有用的，但是血管内神经调节和/或去神经支配的一个挑战是从血管的内部充分地影响神经组织。例如，血管内神经调节应当避免增加急性和/或晚期狭窄的危险。因此，将期望提供进一步解决这些挑战的方法和装置。
附图简述
考虑到结合附图的下列详细描述，本发明的几个实施方案将变得显然，在所述附图中，所有附图的类似参考字符是指类似的部分，并且其中：
图1是显示紧邻动脉的神经纤维的一般位置的示意性等距详图。
图2A-2J是部分截面形式的示意性侧视图，其示例了用于体腔的非连续周缘治疗的方法和装置的一个实例。
图3是部分截面形式的示意性侧视图，其示例图2的方法和装置的一个备选实施方案。
图4是部分截面形式的示意性侧视图，其示例用于非连续周缘治疗的其他备选方法和装置。
图5A和5B是部分截面形式的示意性侧视图，其示例用于非连续周缘治疗的更进一步的备选方法和装置。
详细描述
A.概述
本申请人已经发现，可以期望通过对离散区施加能量来进行体腔的周缘治疗以积极地影响医学病症，所述离散区沿大体上垂直于腔壁的径向横截面的完全的周缘是非连续的。例如，在心房纤维性颤动的治疗中，通过形成连续的周缘损害以中断异常电信号，可以实现周缘治疗，所述连续的周缘损害在肺静脉的径向横截面周围完全连续。在心力衰竭的治疗中，通过形成类似的连续的周缘损害以降低肾交感神经活性，可以实现周缘治疗，所述类似的连续的周缘损害在肾动脉的径向横截面周围完全连续。然而，在垂直于体腔或接近体腔的组织的径向横截面的周缘几乎完全360°连续延伸的连续周缘损害可能增加血管内急性和/或晚期狭窄形成的危险。因此，许多下述实施方案旨在形成腔内的离散的、非连续的损害，而不不利地影响血管。
这种非连续治疗可以例如从血管内或管腔内位置实施，其可以包括利用从血管内位置通到血管外位置的元件的治疗，即血管内-至-血管外治疗。然而，应当理解，还可以提供根据本发明的血管外治疗装置和方法。
本治疗可以相对地应用于神经，包括脑中的神经组织，或在血管或其它体腔内或接近血管或其它体腔、至少总体上平行或沿着血管(体腔)的纵向维度行进的其它靶结构。该靶结构另外或备选地可以包括相对于血管(体腔)的旋转取向。非连续周缘治疗的几个公开的实施方案通过沿多个径向平面或横截面的多个部分处理神经物质，可以降低急性和/或晚期狭窄形成的危险，所述多个径向平面或横截面的多个部分沿血管(体腔)的纵向维度被隔开。
在每一个径向平面或横截面的治疗区域限定了沿周缘不完全连续的治疗区，即，限定了没有连续周缘损害的治疗区。然而，沿多个径向平面或横截面的多个治疗区的叠置限定了沿血管(体腔)的纵向节段的非连续的、重叠的周缘治疗区。在一些实施方案中，此重叠的治疗区可以提供非连续的，但是基本上完全的周缘治疗，而没有连续周缘损害的形成。在其它的实施方案中，重叠的治疗区可以提供非连续的、部分的周缘治疗。
与在单个的纵向横截面或径向平面的连续周缘治疗相比，以此方式在血管(体腔)的纵向节段上进行不连续的周缘治疗。因而，周缘地以不连续的方式影响基本上沿血管(体腔)的纵向维度行进的靶结构，而没有沿血管(体腔)的任何横截面或径向平面的连续周缘损害的形成。这可以降低血管(体腔)内急性或晚期狭窄形成的危险。因而，不连续的周缘治疗可以包括在体腔的纵向维度周围的多个位置进行的治疗，其中在任何一个纵向位置的治疗区不包括完全在径向平面周围的连续周缘损害，但是其中在全部或一些纵向位置的治疗区的叠置可以限定重叠的周缘治疗区。
经由在体腔内接近靶神经纤维安置的用于对靶神经纤维施加能量的装置，可以任选地实现不连续的周缘治疗。该治疗可以经由下列方式引起，例如，电和/或磁能应用、热能应用(加热或冷却)、机械能应用、化学能应用、核或辐射能应用、流体能应用等。这样的治疗可以经由，例如，热或非热电场、连续或脉冲电场、激励电场、局部药物递送、高强度聚焦超声、热技术、无热技术、它们的组合等实现。这种治疗可以例如实现不可逆的电穿孔或电融合、坏死和/或凋亡的诱导、基因表达的改变、动作电位阻滞或衰减、细胞因子上调的变化、消融以及靶神经纤维中的其它状况。该装置的全部或一部分任选可以通过体腔壁达到腔外位置，以帮助所述治疗。该体腔可以例如包括血管，并且该装置可以经由熟知的经皮技术安置在血管内。
经由对靶结构(例如靶神经结构)的直接改变，或至少部分地经由对血管或支持靶结构或周围组织如动脉、小动脉、毛细管、静脉或小静脉的其它结构的改变，可以实现治疗。在一些实施方案中，经由将能量直接施加于靶或支持结构，可以实现该治疗。在其它的实施方案中，经由间接产生和/或施加能量，例如通过施加在靶或支持结构中引起阻抗性加热的电场或高强度聚焦超声，可以实现该治疗。还可以利用备选的热技术。
在一些实施方案中，可以提供用于实时监控治疗及其对靶或支持结构和/或非靶组织的效果的方法和装置。同样地，可以提供能量传输装置的实时监控。另外地或备选地，可以监控传输的功率或总能量、靶或非靶组织或装置的阻抗和/或温度。
当利用电场实现期望的周缘治疗时，可以将电场参数根据需要更改并且以任意组合结合。这样的参数可以包括但不限于电压、功率、场强、脉冲宽度、脉冲持续时间、脉冲的形状、脉冲的数量和/或脉冲之间的间隔(例如，工作循环)等。例如，适当的场强可以高达约10,000V/cm，并且可以是连续的或脉冲的。电波形的适当形状包括例如AC波形、正弦波形、余弦波形、正弦和余弦波的组合、DC波形、DC-移位的AC波形、RF波形、方波、梯形波、指数衰减波、或它们的组合。
当利用脉冲电场时，适当的脉冲宽度可以具有任何期望的间隔，例如高达约1秒。该场包括至少一个脉冲，并且在许多应用中，该场包括多个脉冲或被连续施加例如高达几分钟。适当的脉冲间隔包括例如小于约10秒的间隔。这些参数被作为适当的实例提供并且绝不应当被认为是限制性的。
当利用热机构实现期望的治疗时，可以任选提供保护性元件，以在热诱导的不连续周缘治疗期间保护非靶组织如平滑肌细胞免受热损伤。例如，在加热靶神经或支持结构时，可以提供保护性冷却元件如对流冷却元件，以保护非靶组织。同样地，在冷却靶神经或支持结构时，可以利用保护性加热元件如对流加热元件，以保护非靶组织。可以直接或间接地将热能短暂施加或施加一段持续的时期，以实现例如期望的神经调节或去神经支配。任选地，可以将反馈如沿靶或非靶组织或沿所述装置的感应温度用于控制并监控热能的传递。
通过利用血流作为吸收过量热能(热的或冷的)的传导和/或对流散热器，可以在例如神经调节或去神经支配的过程中任选保护非靶组织。例如，当血流不阻塞时，循环血可以提供相对不变的温度介质，以在此程序中将过量的热能从非靶组织移去。另外地或备选地，可以通过下列方法保护非靶组织：将热(或其它的)能聚焦在靶或支持结构上，使得能量的强度不足以在远离靶或支持结构的非靶组织中引起热损伤。
如以下所述的，可以利用另外和备选的方法和装置实现不连续的周缘治疗，而不形成连续的周缘损害。为了更好地理解本发明的装置的结构以及使用这种用于不连续周缘治疗的装置的方法，研究人的一般神经血管解剖结构是有益的。
B.神经血管解剖结构概述
图1示例了相对于典型为动脉的体腔或血管结构，神经结构的一般解剖学布置。神经纤维N通常可以在沿动脉A的径向维度r的位置的较小范围附近，通常在动脉的外膜内，沿纵向维度L纵向延伸。动脉A具有平滑肌细胞SMC，平滑肌细胞SMC包围动脉周缘并且通常围绕动脉的角维度(angular dimension)θ成螺旋形，还在沿径向维度r的位置的较小范围内。因此，动脉的平滑肌细胞具有通常横穿(即，不平行)血管的纵向维度的纵向或较长维度。神经纤维和平滑肌细胞的纵向维度的失配被称为“细胞失配(cellular misalignment)”。
可以使用神经N和平滑肌细胞SMC的细胞失配，在对平滑肌细胞具有减小的影响的情况下选择性地影响神经细胞。更具体地，通过沿着动脉A的沿动脉纵向维度L分开的多个径向或横截面平面进行叠置治疗，而非进行沿动脉的单个径向平面或横截面的连续周缘治疗，可以实现不连续的周缘治疗。以此方式，由于细胞失配，纵向取向的神经纤维可以经历完全的不连续的周缘治疗，而有角度地取向的平滑肌细胞可以仅经历部分周缘治疗。可以任选利用监控元件评估在神经和/或在平滑肌细胞中引起的治疗的程度，以及调节用于实现期望效果的治疗参数。
C.用于体腔的非连续周缘治疗的装置和方法的实施方案
图2-5示例了用于进行非连续周缘治疗的血管内系统和方法的实施例。本申请人已经例如在2005年5月13日提交的共同未决美国专利申请11/129,765和2006年2月27日提交的11/363,867中描述了用于神经调节或去神经支配的血管内和血管内-至-血管外系统，所述两个申请通过引用而结合在此。本申请人还描述了用于神经调节或去神经支配的血管外系统(参见，例如，在2005年7月25日提交的美国专利申请11/189,563，所述申请通过引用而结合在此)，并且应当理解，除血管内(管腔内)或血管内-至-血管外(腔内-至-腔外)系统以外，可以使用血管外(或腔外)系统进行不连续的周缘治疗。本申请人之前已经在例如2006年8月14日提交的共同未决美国专利申请11/504,117中描述了用于神经调节或去神经支配的热系统。
现在参考图2A-2J，装置300的实施方案包括具有任选的定位元件304(例如，气球、可膨胀的金属丝篮、其它机械扩张器等)的导管302和可膨胀的电极元件306，所述可膨胀的电极元件306沿所述导管的轴安置并且示意性地位于所述定位元件之上。电极元件306具有用于将电场传递到靶神经纤维的电连接到场发生器50的一个或多个电极307。在一个备选实施方案中，电极元件306的一个或多个电极307中的一个或多个可以包含用于加热或冷却靶神经纤维以调节该纤维的帕尔贴(Peltier)电极。任选地，一个或多个电极307可以是单独可分配的并且可以以双极形式使用，和/或可以在将外部接地垫(ground pad)附着到患者的外部的情况下以单极形式使用。
场发生器50，以及本文中所述的电极实施方案中的任何一种，可以与本发明的任何实施方案一起使用以传递具有期望的场参数的电场。场发生器50可以在患者外部。应当理解，可以将以下所述的实施方案的电极电连接至所述发生器，尽管每一个实施方案没有明确显示或描述该发生器。此外，可以任选将场发生器安置在患者内部，并且可以任选将电极和/或场发生器临时或永久地植入到患者内部。
定位元件304任选可以安置或另外驱动一个或多个电极307与血管壁接触。定位元件304还可以包括阻抗改变元件，所述阻抗改变元件改变治疗期间血管内的阻抗，以导引电场跨越血管壁。这可以减少实现期望的神经调节或去神经支配所需的能量，并且可以降低对非靶组织的伤害的危险。本申请人之前已经例如在2005年11月4日提交的共同未决美国专利申请序列号11/266,993中描述了阻抗改变元件的使用，所述专利申请通过引用而以全文形式结合在此。当定位元件304包括可膨胀气球，如图2A-J中一样，该气球可以作为用于可膨胀电极元件306的定中心和/或膨胀元件，以及作为阻抗改变电绝缘体，用于引导传递的电场经由一个或多个电极307进入或跨越血管壁以调节靶神经纤维。由元件304提供的电绝缘可以减少用于实现期望的靶纤维调节，直至并且包括含有所述靶纤维的组织的完全去神经支配所必需的电场的施加能量或其它参数的量级。
此外，元件304任选可以用作热元件。例如，它可以充有用于从接触该元件的组织移去热量的起散热器作用的冷流体。相反地，元件304可以充有加热与所述元件接触的组织的温热流体。该元件内的热流体任选可以在定位元件304内循环和/或交换，以有助于更有效的传导和/或对流热传递。如以下在本文中更详细地描述的，热流体还可以用于实现经由热冷却或加热机构的热神经调节。
一个或多个电极307可以是单独的电极(即，独立接触头)、具有普通连接的接触头的节段电极或单个的连续电极。此外，一个或多个电极307可以配置用于提供双极信号，或一个或多个电极307可以一起或单独地与用于单极应用的分开的患者接地垫结合使用。作为备选或除一个或多个电极307沿可膨胀电极元件306的布置以外，如图2中一样，可以将一个或多个电极307附着到定位元件304上，使得它们在定位元件膨胀时接触动脉的壁。在这种变化中，所述一个或多个电极可以例如固定到内侧表面、外侧表面或至少部分地嵌入到定位元件的壁内(参见图5A和5B)。在另一个实施方案中，所述一个或多个电极不接触血管壁，而是可以被安置在血管内的任何期望位置。
一个或多个电极307或装置300的任何其它部分，例如导管302或元件304，另外地或备选地可以包含一个或多个传感器如热电偶310，以监控靶组织、非靶组织、电极、定位元件和/或装置300或患者解剖结构的任何其它部分的温度或其它参数。可以使用测量的一个或多个参数作为反馈来控制治疗计划(regime)。此反馈可以例如用于将一个或多个参数保持在期望阙值之下，所述期望阙值例如为可能对非靶组织引起伤害的阙值。相反地，可以将该反馈用于将一个或多个参数保持在期望阙值以上，所述期望阙值例如为可以诱导靶组织中的期望效果，例如靶神经纤维的神经调节或由靶神经纤维支配的组织的去神经支配。此外，可以将该反馈用于将一个或多个参数保持在将在靶组织中引起期望的效果而不造成非靶组织伤害的范围内。可以任选将多个参数(或在多个位置的同一或多个参数)用作控制反馈以保证期望效果同时减轻不期望的效果。
如在图2A中看到的，可以将导管302以低轮廓传递构造，例如通过引导导管或鞘303，在动脉A内(或在静脉或接近靶神经纤维的任何其它血管内)传递到治疗部位。备选地，可以将导管安置在用于神经调节的多个血管内，例如，在动脉和静脉内。用于电场神经调节的多血管技术之前已经例如在2006年7月12日提交的本申请人的共同未决美国专利申请11/451,728中有描述，所述专利申请通过引用而以全文形式结合在此。
一旦被如所期望地安置在脉管系统内，任选的定位元件304就可以膨胀，以张开电极元件306并且使电极307与血管的内壁接触，如图2B中看到的。然后可以由场发生器50产生电场，所述电场通过导管302传递到电极元件306和电极307，并且经由电极307跨越动脉的壁传递。电场调节沿在动脉壁内或接近动脉的神经纤维的活性，例如至少部分地将受神经纤维支配的组织或器官去神经支配。这可以例如经由对靶神经纤维或支持结构的消融或坏死，或经由非消融损伤或其它变化来实现。电场还可以引起神经纤维中的电穿孔。
如在沿图2B的径向平面I--I取得的图2C的横截面图中看到的，装置300示意性地包括在电极元件306和定位元件304的周缘周围相等地隔开的4个电极307。如在图2D中看到的，当以与外部接地(未示出；本身已知)结合的单极形式使用时，被每一个电极治疗的周缘节段重叠以形成离散的治疗区TZI，所述离散的治疗区TZI围绕垂直于血管壁的径向平面中的动脉的周缘不完全连续。结果，在动脉的周缘周围存在离散的未治疗区UZI。
如在图2E中看到的，例如使定位元件304折叠，可以使电极元件306在动脉的径向维度r周围折叠，使得电极307不接触血管壁。电极元件306可以围绕动脉的角维度θ旋转，以有角度地再安置电极307(最佳地在图2G中示出)。该旋转可以例如通过有角度地旋转导管302实现。在图2E中，电极元件示意性地已经围绕动脉的角维度旋转约45°。在图2A-D中所示的装置300的实施方案中，电极在该装置的周缘周围相等地分开，使得45°角旋转约在图2D中所示的电极的初始位置之间的中途再安置电极。
除电极的角度再安置(angular repositioning)以外，可以将电极沿动脉的纵向维度L再安置，这作为电极307和径向平面I-I之间的纵向偏置也显示于图2E中。这种纵向再安置可以在电极的角度再安置之前、之后或同时发生。如在图2F中看到的，一旦在纵向和角维度两者上再安置，电极元件306就可以在径向维度周围再膨胀，以使电极307接触血管壁。然后可以经由有角度地并且纵向地再安置的电极307传递电场。
在图2G中，沿图2F的径向平面II--II的治疗产生了治疗区TZII和未治疗区UZII。与图2D的治疗区TZI一样，图2G的治疗区TZII在动脉的完全周缘不连续。图2H和2I允许了治疗区TZI和治疗区TZII的比较。在图2H和2I中没有显示装置300，例如，可以已经将该装置从患者移去，从而完成该程序。
如所显示的，分别沿径向平面I--I和II--II的非治疗区UZI和UZII有角度地彼此偏置。如在图2J中看到的，通过将沿动脉A的不同横截面或径向平面定位的治疗区TZI和TZII叠置，就形成复合治疗区TZI-II，所述复合治疗区TZI-II在动脉的纵向节段上提供了非连续的、但是基本上周缘的治疗。此叠置的治疗区有益地没有产生沿垂直于动脉的任何单独的径向平面或横截面的连续周缘损害，与产生连续的周缘损害的之前的周缘治疗相比，这可以降低急性或晚期狭窄形成的危险。
如之前讨论的，通过以不同的角度取向沿多个纵向位置安置电极的非连续周缘治疗，可以优选影响基本上沿动脉的纵向维度延伸的解剖结构。这种解剖结构可以是神经纤维和/或支持神经纤维的结构。此外，这种不连续的周缘治疗可以减轻或减少在围绕动脉的角维度延伸的结构如平滑肌细胞中引起的潜在不期望效果。平滑肌细胞相对于动脉的有角度或周缘取向可以至少部分地解释为何连续的周缘损害可能增加急性或晚期狭窄的危险。
尽管在图2A-J中，电极元件306经由定位元件304膨胀，但是应当理解，根据本发明的可膨胀的电极元件或电极另外地或备选地可以配置用于自膨胀成与血管壁接触。例如，在移去将电极限制在减小的传递构造中的鞘或引导导管303以后，电极可以自膨胀。电极或电极元件可以例如由配置用于自膨胀的形状-记忆元件制成，或接合至配置用于自膨胀的形状-记忆元件。自膨胀实施方案可以任选通过将限制鞘或导管再安置在自膨胀元件上而折叠，以将其从患者收回。
图3示例了具有自膨胀电极元件306’的装置300的备选实施方案。已经从该装置移去的定位元件304。在使用中，装置300在鞘或引导导管303内前进到治疗部位。将鞘移去，并且元件306’自膨胀使电极307与血管壁接触。有利地，血液在治疗区TZI的形成过程中连续流过动脉A。然后可以将元件306’部分或完全地折叠(例如，在鞘303内)，有角度地相对血管旋转，横向地相对血管再安置，并且再膨胀，以与沿不同的径向平面或横截面的血管壁接触。例如，治疗可以在血流的存在下在新的位置并且以新的角度取向进行，以形成重叠治疗区TZII，所述重叠治疗区TZII在与治疗区TZI叠置时，完成不连续的周缘治疗区TZI-II。然后可以将元件306’再折叠，并且可以将装置300从患者移去，以完成该程序。
现在参考图4，可以期望的是，在没有电极或其它能量传递元件的有角度的和/或纵向的再安置的情况下，实现不连续的周缘治疗。为此目的，在另一个实施方案中，装置400包括具有可主动膨胀或自膨胀的金属丝篮404的导管402，所述可主动膨胀或自膨胀的金属丝篮404具有近侧电极406和与所述近侧电极在纵向上分开的远侧电极408。近侧电极406和远侧电极408还在金属丝篮周围径向地分开并且电连接到场发生器50(参见图2A)。近侧电极406可以沿与远侧电极不同的金属丝篮的金属丝安置。因此近侧和远侧电极有角度地并且侧向地彼此偏置。
近侧电极可以独立于远侧电极运行，和/或近侧和远侧电极可以全部以相同的极性运行，例如，作为与外部接地组合的有源电极以单极形式运行。备选地或另外地，近侧电极相互可以以双极形式使用，和/或远侧电极相互可以以双极形式使用。近侧和远侧电极优选不以双极形式一起使用。通过用远侧电极408治疗，可以在动脉周围形成图2H的治疗区TZI。用近侧电极406治疗可以产生图2I的治疗区TZII，所述治疗区TZII相对于所述治疗区TZI有角度地偏置。治疗区TZI和TZII的叠置产生在动脉的纵向节段之上的不连续的周缘治疗区TZI-II。
任选可以同时使用近侧和远侧电极，以同时形成治疗区TZI和TZII。备选地，可以以任何期望的顺序顺次运行电极，以顺次形成治疗区。作为又一个备选方案，经由同时治疗和部分地经由顺次治疗，可以部分地形成治疗区。
图5A和5B描述了在不必再安置电极或其它能量传递元件的情况下的用于不连续周缘治疗的另外的装置和方法。如在图5A和5B中看到的，装置300具有电极元件306”，所述电极元件306”包括连接到或安置在定位元件304周围的花线电路(flex circuit)。经由通过导管302或沿导管302延伸的金属丝，或通过无线方式，所述花线电路被电连接到场发生器50。在图5A中，花线电路包含在定位元件304周围的可折叠圆筒。在图5B中，花线电路包括用于每一个电极307的单独的电连接，这可以有助于花线电路的折叠以进行传递和收回。与图4的装置400的电极一样，图7的电极307在相对于定位元件和血管的多个纵向位置隔开。可以如前所述运行电极，以实现不连续的周缘治疗。由于电极307被示意性地安置在3个不同的纵向位置，因此可以例如经由3个治疗区(在血管内的每一个纵向位置)的叠置形成不连续的周缘治疗。
图2-5示意性地描述了用于没有周缘损害形成的周缘治疗的电学方法和装置。然而，应当理解，备选的能量形式，包括磁、热、化学、核/辐射、流体等，也可以用于实现没有周缘损害的期望的周缘治疗。此外，尽管图2-5示意性地包括装置的完全血管内安置，但是应当理解，任选经由血管内-至-血管外途径可以将该装置的全部或一部分安置在血管外。
在电场(或其它能量)的传递过程中，血管内的血液可以作为用于将过量的热能从非靶组织(例如血管的内壁)移去的传导和/或对流热传递的散热器(热的或冷的)，从而保护非靶组织。当血流在能量传递过程中不被阻塞时，可以增强此效果，如图3和4的实施方案中一样。预期患者血液作为散热器的使用有助于在减少对非靶组织的损伤危险的情况下的较长或较高能量治疗的传递，这可以增强在靶组织如在靶神经纤维的治疗功效。
除使用患者血液作为散热器以外或作为备选方案，可以将热流体(热的或冷的)注射到例如在一个或多个电极或其它能量传递元件上游的血管中，以移去过量的热能并保护非靶组织。热流体可以例如通过装置导管或通过引导导管注射。此外，可以在除血管以外的体腔中使用该方法，所述方法在靶组织的治疗处理过程中，使用注射的热流体将过量热能从非靶组织移去，以保护非靶组织免受热伤害。
尽管以上描述了本发明的优选示意性变化，但是对于本领域的技术人员将显然的是，在不背离本发明的情况下，可以对其进行各种变化和更改。例如，尽管在图2-4的所述实施方案中，不连续的周缘治疗是经由在2个位置的治疗的叠置实现的，但是应当理解，可以将在多于2个位置的治疗叠置以实现周缘治疗，如关于图5A和5B所述的。此外，尽管在所述实施方案中，该方法在血管中进行，但是应当理解，该治疗备选地可以在其它体腔中进行。在后附权利要求中，意欲覆盖落入本发明的精神和范围之内的所有这样的变化和更改。

Claims (25)

1.一种用于患者体腔的不连续周缘治疗的方法，所述方法包括：
至少接近所述体腔的壁安置能量传递元件；
将能量从所述能量传递元件传递至在相对于所述体腔的第一纵向位置的所述体腔的不足整个周缘，以形成第一治疗区；和
将能量从所述能量传递元件传递至在相对于所述体腔的第二纵向位置的所述体腔的不足整个周缘，以至少形成第二治疗区，其中所述第一纵向位置和所述第二纵向位置沿所述腔的纵向维度彼此分开。
2.根据权利要求1所述的方法，其中在所述第二纵向位置传递能量另外包括相对于所述患者的所述体腔再安置所述能量传递元件。
3.根据权利要求1所述的方法，其中接近所述患者的所述体腔安置所述能量传递元件另外包括接近所述患者的血管安置所述能量传递元件。
4.根据权利要求1所述的方法，其中接近所述患者的所述体腔安置所述能量传递元件另外包括在所述患者的所述体腔内安置所述能量传递元件。
5.根据权利要求4所述的方法，其中在所述患者的所述体腔内安置所述能量传递元件另外包括在所述患者的血管内安置所述能量传递元件。
6.根据权利要求5所述的方法，所述方法另外包括在所述能量传递过程中阻塞所述血管内的血流。
7.根据权利要求4所述的方法，其中在所述患者的所述体腔内安置所述能量传递元件另外包括将所述体腔的壁与所述能量传递元件接触。
8.根据权利要求4所述的方法，其中在所述患者的所述体腔内安置所述能量传递元件另外包括在所述能量传递之前，使所述能量传递元件跨越所述体腔的所述壁。
9.根据权利要求1所述的方法，其中接近所述体腔安置所述能量传递元件另外包括安置包括能量传递子元件的能量传递元件，所述能量传递子元件相对于彼此纵向地且有角度地分开。
10.根据权利要求9所述的方法，其中在所述第一和至少第二纵向位置传递能量另外包括用纵向地且有角度地分开的能量传递子元件传递能量。
11.根据权利要求10所述的方法，其中用所述能量传递子元件传递能量另外包括在所述第一和至少第二纵向位置同时传递能量。
12.根据权利要求11所述的方法，其中用所述能量传递子元件传递能量另外包括以任意期望的顺序在所述第一和至少第二纵向位置顺次传递能量。
13.根据权利要求1所述的方法，其中接近所述患者的所述体腔安置所述能量传递元件另外包括接近所述患者的多个体腔安置所述能量传递元件。
14.根据权利要求5所述的方法，其中在所述患者的所述血管内安置所述能量传递元件另外包括在所述患者的肾脉管系统内安置所述能量传递元件。
15.根据权利要求1所述的方法，其中接近所述体腔安置所述能量传递元件另外包括接近所述体腔安置至少一个电极，并且
其中用所述能量传递元件传递能量另外包括从所述至少一个电极传递电场。
16.根据权利要求15所述的方法，所述方法另外包括将外部接地附着到患者的外部，
其中所述电场的传递另外包括在所述至少一个电极和所述外部接地之间以单极方式传递所述电场。
17.用于患者体腔的不连续周缘治疗的装置，所述装置包括：
配置为接近所述体腔安置的器件；
连接到所述装置的第一能量传递元件；和
连接到所述装置的第二能量传递元件，
其中所述第一能量传递元件和所述第二能量传递元件在所述器件的长度周围纵向地且有角度地彼此偏置分开，
其中所述第一能量传递元件和所述第二能量传递元件中的每一个配置为将能量传递至所述患者的所述体腔的不足整个周缘。
18.根据权利要求17所述的装置，其中所述器件包括配置为安置在所述体腔内的导管，并且
其中所述第一能量传递元件和所述第二能量传递元件被连接到可膨胀元件，所述可膨胀元件配置为使所述第一能量传递元件和所述第二能量传递元件与所述体腔的壁接触。
19.根据权利要求18所述的装置，其中所述可膨胀元件配置为在能量传递过程中阻塞所述体腔内的流体流动。
20.根据权利要求17所述的装置，其中所述器件包括配置为安置在所述体腔内的导管，并且
其中所述第一能量传递元件和所述至少第二能量传递元件配置为跨越所述体腔的壁。
21.根据权利要求17所述的装置，所述装置另外包括至少一个传感器，所述至少一个传感器配置为监控所述装置或所述患者内的组织的参数。
22.根据权利要求21所述的装置，所述装置另外包括反馈控制系统，所述反馈控制系统配置为响应于监控到的参数而改变治疗。
23.一种治疗用方法，所述方法包括：
在相对于患者体腔的第一纵向且有角度的位置安置能量传递元件；
将能量从所述能量传递元件传递至在所述第一纵向且有角度的位置的所述体腔的不足整个周缘，以形成第一治疗区；
将所述能量传递元件再安置到相对于所述体腔的第二纵向且有角度的位置，所述第二纵向且有角度的位置与所述第一纵向且有角度的位置不同；和
将能量从所述能量传递元件传递至在所述第二纵向且有角度的位置的所述体腔的不足整个周缘，以形成第二治疗区。
24.根据权利要求23所述的方法，其中经由所述第一治疗区和所述第二治疗区的叠置形成的复合治疗区包括不连续的、完全周缘的治疗区。
25.一种治疗患者的方法，所述方法包括：
将能量传递到在体腔的内壁的第一治疗区并且传递到在所述腔的所述壁的第二治疗区，其中所述第一治疗区在径向平面具有离散的、非连续的第一损害，而所述第二治疗区在与所述第一径向平面分开的第二径向平面具有离散的、非连续的第二损害，并且
影响在所述体腔内壁外的神经组织。
CN2007800496467A 2006-11-14 2007-11-14 用于对体腔进行非连续周缘治疗的装置 Active CN101583323B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201210069381.XA CN102847230B (zh) 2006-11-14 2007-11-14 用于对体腔进行非连续周缘治疗的方法和装置

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/599,890 2006-11-14
US11/599,890 US8347891B2 (en) 2002-04-08 2006-11-14 Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
PCT/US2007/084708 WO2008061152A2 (en) 2006-11-14 2007-11-14 Methods and apparatus for performing a non-continuous circumferential treatment to a body lumen

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210069381.XA Division CN102847230B (zh) 2006-11-14 2007-11-14 用于对体腔进行非连续周缘治疗的方法和装置

Publications (2)

Publication Number Publication Date
CN101583323A true CN101583323A (zh) 2009-11-18
CN101583323B CN101583323B (zh) 2012-07-11

Family

ID=39402459

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201210069381.XA Active CN102847230B (zh) 2006-11-14 2007-11-14 用于对体腔进行非连续周缘治疗的方法和装置
CN2007800496467A Active CN101583323B (zh) 2006-11-14 2007-11-14 用于对体腔进行非连续周缘治疗的装置

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201210069381.XA Active CN102847230B (zh) 2006-11-14 2007-11-14 用于对体腔进行非连续周缘治疗的方法和装置

Country Status (7)

Country Link
US (9) US8347891B2 (zh)
EP (4) EP2623062B1 (zh)
JP (2) JP5469460B2 (zh)
CN (2) CN102847230B (zh)
DE (5) DE202007019646U1 (zh)
ES (3) ES2534611T3 (zh)
WO (1) WO2008061152A2 (zh)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102715949A (zh) * 2010-10-26 2012-10-10 美敦力阿迪安卢森堡有限责任公司 神经调节冷冻治疗设备和相关系统和方法
US8364237B2 (en) 2005-03-28 2013-01-29 Vessix Vascular, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8401667B2 (en) 2008-11-17 2013-03-19 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
CN103908334A (zh) * 2012-12-31 2014-07-09 上海微创电生理医疗科技有限公司 多电极消融导管
CN103957981A (zh) * 2011-08-24 2014-07-30 理查德·R·休瑟 利用能量治疗高血压的设备和方法
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US9125666B2 (en) 2003-09-12 2015-09-08 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US9125667B2 (en) 2004-09-10 2015-09-08 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
CN105473090A (zh) * 2013-03-15 2016-04-06 波士顿科学国际有限公司 重建身体通道的组织或邻近身体通道的组织的方法及装置
CN105473091A (zh) * 2013-06-21 2016-04-06 波士顿科学国际有限公司 具有可一起移动的电极支撑件的肾脏去神经球囊导管
CN105555348A (zh) * 2013-09-09 2016-05-04 美敦力阿迪安卢森堡有限公司 具有能量递送热电偶组件的神经调节导管装置和系统以及相关方法
CN105578982A (zh) * 2013-09-30 2016-05-11 美敦力阿迪安卢森堡有限公司 具有螺旋轨道的血管内神经调节装置及相关方法
CN106852703A (zh) * 2015-12-08 2017-06-16 上海安通医疗科技有限公司 一种肾动脉射频消融导管
US9974607B2 (en) 2006-10-18 2018-05-22 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
CN108095821A (zh) * 2011-11-08 2018-06-01 波士顿科学西美德公司 孔部肾神经消融
KR101912960B1 (ko) 2010-10-25 2018-10-29 메드트로닉 아르디언 룩셈부르크 에스에이알엘 다중전극 어레이를 구비한 신장 신경조절용 카테터 장치 및 관련된 시스템 및 방법
US10357302B2 (en) 2011-07-12 2019-07-23 Verve Medical, Inc. Renal nerve denervation via the renal pelvis
US10420606B2 (en) 2002-04-08 2019-09-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen

Families Citing this family (503)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US6634363B1 (en) 1997-04-07 2003-10-21 Broncus Technologies, Inc. Methods of treating lungs having reversible obstructive pulmonary disease
US7992572B2 (en) 1998-06-10 2011-08-09 Asthmatx, Inc. Methods of evaluating individuals having reversible obstructive pulmonary disease
US7027869B2 (en) 1998-01-07 2006-04-11 Asthmatx, Inc. Method for treating an asthma attack
US7921855B2 (en) 1998-01-07 2011-04-12 Asthmatx, Inc. Method for treating an asthma attack
US8016823B2 (en) 2003-01-18 2011-09-13 Tsunami Medtech, Llc Medical instrument and method of use
US7198635B2 (en) 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US8181656B2 (en) 1998-06-10 2012-05-22 Asthmatx, Inc. Methods for treating airways
CA2387127A1 (en) 1999-10-25 2001-05-17 Therus Corporation Use of focused ultrasound for vascular sealing
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US8251070B2 (en) 2000-03-27 2012-08-28 Asthmatx, Inc. Methods for treating airways
US7104987B2 (en) 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US9433457B2 (en) 2000-12-09 2016-09-06 Tsunami Medtech, Llc Medical instruments and techniques for thermally-mediated therapies
US8974446B2 (en) * 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US8444636B2 (en) 2001-12-07 2013-05-21 Tsunami Medtech, Llc Medical instrument and method of use
US7620451B2 (en) * 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20110207758A1 (en) 2003-04-08 2011-08-25 Medtronic Vascular, Inc. Methods for Therapeutic Renal Denervation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US7756583B2 (en) * 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US7258690B2 (en) 2003-03-28 2007-08-21 Relievant Medsystems, Inc. Windowed thermal ablation probe
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US6907884B2 (en) 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
US8579892B2 (en) 2003-10-07 2013-11-12 Tsunami Medtech, Llc Medical system and method of use
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US20070016272A1 (en) * 2004-09-27 2007-01-18 Thompson Russell B Systems and methods for treating a hollow anatomical structure
US7937143B2 (en) * 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
WO2007014063A2 (en) 2005-07-21 2007-02-01 Vnus Medical Technologies, Inc. Systems and methods for treating a hollow anatomical structure
JP5826450B2 (ja) 2005-07-22 2015-12-02 ザ ファウンドリー， エルエルシー 治療薬の送達のためのシステムおよび方法
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
AU2007212587B2 (en) * 2006-02-03 2012-07-12 Synecor, Llc Intravascular device for neuromodulation
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
EP2092957B2 (en) * 2006-06-28 2019-11-20 Medtronic Ardian Luxembourg S.à.r.l. Systems for thermally-induced renal neuromodulation
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US8216217B2 (en) 2007-08-23 2012-07-10 Aegea Medical, Inc. Uterine therapy device and method
US20090018723A1 (en) * 2007-07-12 2009-01-15 Dan Chevion Driver/Vehicle Interface Combining Dynamic Function Modification of Vehicle Controls with Haptic Feedback
CA2694498C (en) 2007-07-20 2014-12-02 Boston Scientific Neuromodulation Corporation Use of stimulation pulse shape to control neural recruitment order and clinical effect
US11376435B2 (en) 2007-07-20 2022-07-05 Boston Scientific Neuromodulation Corporation System and method for shaped phased current delivery
US9717501B2 (en) * 2007-11-21 2017-08-01 St. Jude Medical, Atrial Fibrillation Division, Inc. Methods and systems for occluding vessels during cardiac ablation including optional electroanatomical guidance
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
US9924992B2 (en) 2008-02-20 2018-03-27 Tsunami Medtech, Llc Medical system and method of use
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
US9943401B2 (en) 2008-04-04 2018-04-17 Eugene de Juan, Jr. Therapeutic device for pain management and vision
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10702326B2 (en) * 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
US8721632B2 (en) 2008-09-09 2014-05-13 Tsunami Medtech, Llc Methods for delivering energy into a target tissue of a body
US8713026B2 (en) * 2008-06-13 2014-04-29 Sandisk Technologies Inc. Method for playing digital media files with a digital media player using a plurality of playlists
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8768469B2 (en) 2008-08-08 2014-07-01 Enteromedics Inc. Systems for regulation of blood pressure and heart rate
AU2009296474B2 (en) 2008-09-26 2015-07-02 Relievant Medsystems, Inc. Systems and methods for navigating an instrument through bone
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
US20140358140A1 (en) * 2008-10-21 2014-12-04 Microcube, Llc Microwave treatment devices and methods
US11291503B2 (en) 2008-10-21 2022-04-05 Microcube, Llc Microwave treatment devices and methods
US11219484B2 (en) 2008-10-21 2022-01-11 Microcube, Llc Methods and devices for delivering microwave energy
US9980774B2 (en) 2008-10-21 2018-05-29 Microcube, Llc Methods and devices for delivering microwave energy
CN102256560B (zh) 2008-11-10 2014-07-09 微立方有限责任公司 将能量应用于身体组织的方法和装置
CN104068933B (zh) * 2008-11-11 2017-03-15 施菲姆德控股有限责任公司 小外形的电极组件
US9795442B2 (en) 2008-11-11 2017-10-24 Shifamed Holdings, Llc Ablation catheters
US11376061B2 (en) * 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US20100160906A1 (en) * 2008-12-23 2010-06-24 Asthmatx, Inc. Expandable energy delivery devices having flexible conductive elements and associated systems and methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US20100168739A1 (en) * 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
WO2010080886A1 (en) 2009-01-09 2010-07-15 Recor Medical, Inc. Methods and apparatus for treatment of mitral valve in insufficiency
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US20120035603A1 (en) * 2009-01-20 2012-02-09 Advanced Cardica Therapeutics Inc. Method and apparatus for minimizing thermal trauma to an organ during tissue ablation of a different organ
US11284931B2 (en) 2009-02-03 2022-03-29 Tsunami Medtech, Llc Medical systems and methods for ablating and absorbing tissue
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9277961B2 (en) 2009-06-12 2016-03-08 Advanced Cardiac Therapeutics, Inc. Systems and methods of radiometrically determining a hot-spot temperature of tissue being treated
US9226791B2 (en) 2012-03-12 2016-01-05 Advanced Cardiac Therapeutics, Inc. Systems for temperature-controlled ablation using radiometric feedback
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) * 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US8591025B1 (en) 2012-09-11 2013-11-26 Nexisvision, Inc. Eye covering and refractive correction methods for LASIK and other applications
WO2011050365A1 (en) 2009-10-23 2011-04-28 Forsight Labs, Llc Conformable therapeutic shield for vision and pain
ES2649890T3 (es) * 2009-10-23 2018-01-16 Nexisvision, Inc. Enervación corneal para el tratamiento de dolor ocular
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
CN102596320B (zh) * 2009-10-30 2016-09-07 瑞蔻医药有限公司 通过经皮超声波去肾神经治疗高血压的方法和装置
US20110112400A1 (en) * 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
US8900223B2 (en) 2009-11-06 2014-12-02 Tsunami Medtech, Llc Tissue ablation systems and methods of use
US20110112527A1 (en) * 2009-11-06 2011-05-12 Angiodynamics, Inc. Flexible medical ablation device and method of use
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
AU2010319333B2 (en) 2009-11-13 2014-02-20 St. Jude Medical, Inc. Assembly of staggered ablation elements
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9161801B2 (en) 2009-12-30 2015-10-20 Tsunami Medtech, Llc Medical system and method of use
US20110263921A1 (en) * 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
EP2525715A4 (en) * 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY
US8764744B2 (en) * 2010-01-25 2014-07-01 Covidien Lp System for monitoring ablation size
CA2787062C (en) 2010-01-26 2017-07-11 Michael A. Evans Methods, devices, and agents for denervation
US20110208173A1 (en) * 2010-02-24 2011-08-25 Medtronic Vascular, Inc. Methods for Treating sleep apnea via renal Denervation
US8556891B2 (en) 2010-03-03 2013-10-15 Medtronic Ablation Frontiers Llc Variable-output radiofrequency ablation power supply
US9192790B2 (en) 2010-04-14 2015-11-24 Boston Scientific Scimed, Inc. Focused ultrasonic renal denervation
CA2796865A1 (en) * 2010-04-26 2011-11-10 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US9655677B2 (en) 2010-05-12 2017-05-23 Shifamed Holdings, Llc Ablation catheters including a balloon and electrodes
JP5792802B2 (ja) 2010-05-12 2015-10-14 シファメド・ホールディングス・エルエルシー 低い外形の電極組立体
US8473067B2 (en) 2010-06-11 2013-06-25 Boston Scientific Scimed, Inc. Renal denervation and stimulation employing wireless vascular energy transfer arrangement
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9408661B2 (en) 2010-07-30 2016-08-09 Patrick A. Haverkost RF electrodes on multiple flexible wires for renal nerve ablation
US20120029512A1 (en) * 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US9155589B2 (en) 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9358365B2 (en) 2010-07-30 2016-06-07 Boston Scientific Scimed, Inc. Precision electrode movement control for renal nerve ablation
EP2600784B1 (en) 2010-08-05 2021-12-29 Medtronic Ireland Manufacturing Unlimited Company Cryoablation apparatuses, systems, and methods for renal neuromodulation
US9943353B2 (en) 2013-03-15 2018-04-17 Tsunami Medtech, Llc Medical system and method of use
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
US9028417B2 (en) 2010-10-18 2015-05-12 CardioSonic Ltd. Ultrasound emission element
US8585601B2 (en) 2010-10-18 2013-11-19 CardioSonic Ltd. Ultrasound transducer
WO2012052926A2 (en) 2010-10-18 2012-04-26 CardioSonic Ltd. Tissue treatment
US9566456B2 (en) * 2010-10-18 2017-02-14 CardioSonic Ltd. Ultrasound transceiver and cooling thereof
CN202478392U (zh) * 2010-10-20 2012-10-10 美敦力阿迪安卢森堡有限责任公司 导管设备关联系统
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
CN103281995B (zh) 2010-10-25 2016-04-06 内希斯视觉股份有限公司 识别针对视力的眼睛覆盖物的方法和设备
EP4059459A1 (en) 2010-10-25 2022-09-21 Medtronic Ireland Manufacturing Unlimited Company Microwave catheter apparatuses for renal neuromodulation
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
EP3449856B1 (en) 2010-10-25 2023-06-28 Medtronic Ardian Luxembourg S.à.r.l. Device for evaluation and feedback of neuromodulation treatment
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US9220558B2 (en) 2010-10-27 2015-12-29 Boston Scientific Scimed, Inc. RF renal denervation catheter with multiple independent electrodes
WO2012064864A1 (en) 2010-11-09 2012-05-18 Aegea Medical Inc. Positioning method and apparatus for delivering vapor to the uterus
US9028485B2 (en) 2010-11-15 2015-05-12 Boston Scientific Scimed, Inc. Self-expanding cooling electrode for renal nerve ablation
US9089350B2 (en) 2010-11-16 2015-07-28 Boston Scientific Scimed, Inc. Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
US9668811B2 (en) 2010-11-16 2017-06-06 Boston Scientific Scimed, Inc. Minimally invasive access for renal nerve ablation
US9326751B2 (en) 2010-11-17 2016-05-03 Boston Scientific Scimed, Inc. Catheter guidance of external energy for renal denervation
AU2011328921B2 (en) 2010-11-17 2015-07-09 Medtronic Af Luxembourg S.A.R.L. Therapeutic renal neuromodulation for treating dyspnea and associated systems and methods
US9060761B2 (en) 2010-11-18 2015-06-23 Boston Scientific Scime, Inc. Catheter-focused magnetic field induced renal nerve ablation
US9192435B2 (en) * 2010-11-22 2015-11-24 Boston Scientific Scimed, Inc. Renal denervation catheter with cooled RF electrode
US9023034B2 (en) 2010-11-22 2015-05-05 Boston Scientific Scimed, Inc. Renal ablation electrode with force-activatable conduction apparatus
US20120157993A1 (en) 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
US20120232409A1 (en) * 2010-12-15 2012-09-13 Stahmann Jeffrey E System and method for renal artery occlusion during renal denervation therapy
CN203354638U (zh) * 2010-12-21 2013-12-25 泰尔茂株式会社 气囊导管及通电系统
US9220561B2 (en) 2011-01-19 2015-12-29 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
US20140163540A1 (en) 2011-02-18 2014-06-12 Recor Medical, Inc. Apparatus for effecting renal denervation using ultrasound
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US20120259269A1 (en) 2011-04-08 2012-10-11 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US8663190B2 (en) 2011-04-22 2014-03-04 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
CN103930061B (zh) 2011-04-25 2016-09-14 美敦力阿迪安卢森堡有限责任公司 用于限制导管壁低温消融的有关低温球囊限制部署的装置及方法
WO2012149205A1 (en) 2011-04-27 2012-11-01 Dolan Mark J Nerve impingement systems including an intravascular prosthesis and an extravascular prosthesis and associated systems and methods
WO2014210186A2 (en) 2013-06-26 2014-12-31 Nexisvision, Inc. Contact lenses for refractive correction
JP2014514613A (ja) 2011-04-28 2014-06-19 ネクシスビジョン， インコーポレイテッド 涙流、快適性、および／または適用性が改善された、眼被覆物および屈折矯正法および装置
US8909316B2 (en) 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
EP2706938A4 (en) * 2011-06-15 2014-11-26 Tidal Wave Technology Inc CATHETER DEVICE FOR ABLATION BY HIGH FREQUENCY
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
WO2013016203A1 (en) 2011-07-22 2013-01-31 Boston Scientific Scimed, Inc. Nerve modulation system with a nerve modulation element positionable in a helical guide
JP6318088B2 (ja) 2011-07-26 2018-04-25 アンフォラ メディカル， インコーポレイテッド 骨盤神経組織を変調するための装置および方法
US9056185B2 (en) 2011-08-24 2015-06-16 Ablative Solutions, Inc. Expandable catheter system for fluid injection into and deep to the wall of a blood vessel
US9278196B2 (en) 2011-08-24 2016-03-08 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
AU2012298709B2 (en) 2011-08-25 2015-04-16 Covidien Lp Systems, devices, and methods for treatment of luminal tissue
JP6188159B2 (ja) * 2011-08-26 2017-08-30 サイマップ ホールディング リミテッド 動脈壁を支配する機能的神経を位置決し、識別するためのシステムおよび方法ならびにそのカテーテル
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9427579B2 (en) 2011-09-29 2016-08-30 Pacesetter, Inc. System and method for performing renal denervation verification
WO2013052501A1 (en) 2011-10-05 2013-04-11 Innovative Pulmonary Solutions, Inc. Apparatus for injuring nerve tissue
US9662060B2 (en) 2011-10-07 2017-05-30 Aegea Medical Inc. Integrity testing method and apparatus for delivering vapor to the uterus
EP2765942B1 (en) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
US9420955B2 (en) 2011-10-11 2016-08-23 Boston Scientific Scimed, Inc. Intravascular temperature monitoring system and method
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
US20130096550A1 (en) * 2011-10-18 2013-04-18 Boston Scientific Scimed, Inc. Ablative catheter with electrode cooling and related methods of use
US9629675B2 (en) * 2011-10-19 2017-04-25 Confluent Medical Technologies, Inc. Tissue treatment device and related methods
US9327123B2 (en) 2011-11-07 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Endovascular nerve monitoring devices and associated systems and methods
US20130116683A1 (en) * 2011-11-09 2013-05-09 Tsunami Medtech, Llc Medical system and method of use
EP2779929A1 (en) 2011-11-15 2014-09-24 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US9192766B2 (en) 2011-12-02 2015-11-24 Medtronic Ardian Luxembourg S.A.R.L. Renal neuromodulation methods and devices for treatment of polycystic kidney disease
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
JP2015503954A (ja) * 2011-12-15 2015-02-05 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォードジュニア ユニバーシティＴｈｅ Ｂｏａｒｄ ｏｆ Ｔｒｕｓｔｅｅｓ ｏｆ ｔｈｅ Ｌｅｌａｎｄ Ｓｔａｎｆｏｒｄ Ｊｕｎｉｏｒ Ｕｎｉｖｅｒｓｉｔｙ 肺高血圧症を治療するための装置および方法
EP2790768A4 (en) * 2011-12-15 2015-07-15 Univ Leland Stanford Junior DEVICE AND METHOD FOR THE TREATMENT OF PULMONARY HYPERTONIA
US9265969B2 (en) 2011-12-21 2016-02-23 Cardiac Pacemakers, Inc. Methods for modulating cell function
WO2013096913A2 (en) * 2011-12-23 2013-06-27 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
WO2013101772A1 (en) 2011-12-30 2013-07-04 Relievant Medsystems, Inc. Systems and methods for treating back pain
EP2809399B1 (en) 2012-01-30 2023-04-19 Auris Health, Inc. Tissue necrosis apparatus
CN104254367A (zh) 2012-03-07 2014-12-31 美敦力阿迪安卢森堡有限公司 肾神经的选择性调制
US11013549B2 (en) 2012-03-08 2021-05-25 Medtronic Ardian Luxembourg S.A.R.L. Gastrointestinal neuromodulation and associated systems and methods
US9750568B2 (en) 2012-03-08 2017-09-05 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
AU2013230893B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the management of pain
WO2013134733A2 (en) 2012-03-08 2013-09-12 Medtronic Ardian Luxembourg Sarl Biomarker sampling in the context of neuromodulation devices and associated systems and methods
AU2013230886B2 (en) 2012-03-08 2015-10-01 Medtronic Af Luxembourg S.A.R.L. Renal neuromodulation methods and systems for treatment of hyperaldosteronism
AU2013230906A1 (en) 2012-03-08 2014-09-18 Medtronic Af Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of sexual dysfunction
US8934988B2 (en) 2012-03-16 2015-01-13 St. Jude Medical Ab Ablation stent with meander structure
US10357304B2 (en) 2012-04-18 2019-07-23 CardioSonic Ltd. Tissue treatment
US9113929B2 (en) 2012-04-19 2015-08-25 St. Jude Medical, Cardiology Division, Inc. Non-electric field renal denervation electrode
WO2013184239A1 (en) 2012-04-20 2013-12-12 Nexisvision, Inc. Contact lenses for refractive correction
US9465233B2 (en) 2012-04-20 2016-10-11 Nexisvision, Inc. Bimodular contact lenses
US20150088113A1 (en) 2012-04-27 2015-03-26 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices for renal neuromodulation and associated systems and methods
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
WO2013162722A1 (en) 2012-04-27 2013-10-31 Medtronic Ardian Luxembourg Sarl Methods and devices for localized disease treatment by ablation
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
US9943354B2 (en) 2012-04-27 2018-04-17 Medtronic Ardian Luxembourg S.A.R.L. Methods and devices for localized inhibition of inflammation by ablation
US20140207136A1 (en) * 2012-05-04 2014-07-24 St. Jude Medical, Inc. Multiple staggered electrodes connected via flexible joints
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
JP2013236662A (ja) * 2012-05-11 2013-11-28 Olympus Corp 神経刺激電極および神経刺激システム
BR112014028131A2 (pt) 2012-05-11 2017-06-27 Medtronic Ardian Luxembourg aparelho de cateter, sistema de neuromodulação renal, e, método para realizar neuromodulação renal
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US11357447B2 (en) 2012-05-31 2022-06-14 Sonivie Ltd. Method and/or apparatus for measuring renal denervation effectiveness
EP2854682B1 (en) 2012-06-04 2021-06-23 Boston Scientific Scimed, Inc. Systems for treating tissue of a passageway within a body
US8951296B2 (en) 2012-06-29 2015-02-10 Medtronic Ardian Luxembourg S.A.R.L. Devices and methods for photodynamically modulating neural function in a human
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9381063B2 (en) 2012-07-13 2016-07-05 Magnetecs Inc. Method and apparatus for magnetically guided catheter for renal denervation employing MOSFET sensor array
US20140025069A1 (en) * 2012-07-17 2014-01-23 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
EP2877113B1 (en) 2012-07-24 2018-07-25 Boston Scientific Scimed, Inc. Electrodes for tissue treatment
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) * 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
EP3603501A1 (en) 2012-08-09 2020-02-05 University of Iowa Research Foundation Catheter systems for surrounding a tissue structure
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
US20140067029A1 (en) * 2012-08-28 2014-03-06 Boston Scientific Scimed, Inc. Renal nerve modulation and ablation catheter electrode design
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
US8612022B1 (en) 2012-09-13 2013-12-17 Invatec S.P.A. Neuromodulation catheters and associated systems and methods
JP2014054430A (ja) * 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
CN104768487A (zh) * 2012-09-13 2015-07-08 波士顿科学西美德公司 肾脏神经调节球囊及其制造和使用方法
EP2895095A2 (en) 2012-09-17 2015-07-22 Boston Scientific Scimed, Inc. Self-positioning electrode system and method for renal nerve modulation
WO2014047355A1 (en) 2012-09-19 2014-03-27 Denervx LLC Cooled microwave denervation
US10549127B2 (en) 2012-09-21 2020-02-04 Boston Scientific Scimed, Inc. Self-cooling ultrasound ablation catheter
US10398464B2 (en) 2012-09-21 2019-09-03 Boston Scientific Scimed, Inc. System for nerve modulation and innocuous thermal gradient nerve block
JP6074051B2 (ja) 2012-10-10 2017-02-01 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 血管内神経変調システム及び医療用デバイス
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
WO2014066432A2 (en) 2012-10-22 2014-05-01 Medtronic Ardian Luxembourg Sarl Catheters with enhanced flexibility and associated devices, systems, and methods
US10945787B2 (en) 2012-10-29 2021-03-16 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US10881458B2 (en) 2012-10-29 2021-01-05 Ablative Solutions, Inc. Peri-vascular tissue ablation catheters
US9526827B2 (en) 2012-10-29 2016-12-27 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US10226278B2 (en) 2012-10-29 2019-03-12 Ablative Solutions, Inc. Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US9554849B2 (en) 2012-10-29 2017-01-31 Ablative Solutions, Inc. Transvascular method of treating hypertension
US10736656B2 (en) 2012-10-29 2020-08-11 Ablative Solutions Method for painless renal denervation using a peri-vascular tissue ablation catheter with support structures
US9272132B2 (en) 2012-11-02 2016-03-01 Boston Scientific Scimed, Inc. Medical device for treating airways and related methods of use
US9770593B2 (en) 2012-11-05 2017-09-26 Pythagoras Medical Ltd. Patient selection using a transluminally-applied electric current
EP2914186B1 (en) 2012-11-05 2019-03-13 Relievant Medsystems, Inc. Systems for creating curved paths through bone and modulating nerves within the bone
CN104902836B (zh) 2012-11-05 2017-08-08 毕达哥拉斯医疗有限公司 受控组织消融
WO2014071372A1 (en) 2012-11-05 2014-05-08 Boston Scientific Scimed, Inc. Devices for delivering energy to body lumens
CN102908191A (zh) 2012-11-13 2013-02-06 陈绍良 多极同步肺动脉射频消融导管
US11241267B2 (en) 2012-11-13 2022-02-08 Pulnovo Medical (Wuxi) Co., Ltd Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9827036B2 (en) 2012-11-13 2017-11-28 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US9888956B2 (en) 2013-01-22 2018-02-13 Angiodynamics, Inc. Integrated pump and generator device and method of use
WO2014122788A1 (ja) * 2013-02-08 2014-08-14 テルモ株式会社 医療器具
US20140228875A1 (en) 2013-02-08 2014-08-14 Nidus Medical, Llc Surgical device with integrated visualization and cauterization
US20140243807A1 (en) * 2013-02-22 2014-08-28 James Margolis Devices and methods for denervation of the nerves surrounding the pulmonary veins for treatment of atrial fibrillation
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
US9179997B2 (en) 2013-03-06 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Thermochromic polyvinyl alcohol based hydrogel artery
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
US10328238B2 (en) 2013-03-12 2019-06-25 St. Jude Medical, Cardiology Division, Inc. Catheter system
EP2777739B1 (en) 2013-03-12 2018-09-05 St. Jude Medical, Cardiology Division, Inc. Catheter system
EP2777741A3 (en) 2013-03-12 2015-01-21 St. Jude Medical, Cardiology Division, Inc. Catheter system
US9510902B2 (en) 2013-03-13 2016-12-06 St. Jude Medical, Cardiology Division, Inc. Ablation catheters and systems including rotational monitoring means
CN105188587A (zh) * 2013-03-13 2015-12-23 波士顿科学医学有限公司 具有线性离子化传导性气球的可转向消融设备
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US9861431B2 (en) * 2013-03-13 2018-01-09 Kyphon SÀRL Radiofrequency inflatable device
WO2014159273A1 (en) 2013-03-14 2014-10-02 Recor Medical, Inc. Methods of plating or coating ultrasound transducers
EP3799931A1 (en) 2013-03-14 2021-04-07 ReCor Medical, Inc. Ultrasound-based neuromodulation system
US8876813B2 (en) 2013-03-14 2014-11-04 St. Jude Medical, Inc. Methods, systems, and apparatus for neural signal detection
US9131982B2 (en) 2013-03-14 2015-09-15 St. Jude Medical, Cardiology Division, Inc. Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
US9561070B2 (en) 2013-03-15 2017-02-07 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
AU2014233354B2 (en) 2013-03-15 2017-01-12 Medtronic Af Luxembourg S.A.R.L. Controlled neuromodulation systems and methods of use
US9066726B2 (en) 2013-03-15 2015-06-30 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode apposition judgment using pressure elements
US20140275993A1 (en) * 2013-03-15 2014-09-18 Medtronic Ardian Luxembourg S.a.r.I. Devices, Systems, and Methods for Specialization of Neuromodulation Treatment
US9345540B2 (en) * 2013-03-15 2016-05-24 Medtronic Ablation Frontiers Llc Contact specific RF therapy balloon
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
US9173701B2 (en) 2013-03-15 2015-11-03 Warsaw Orthopedic, Inc. RF enabled inflatable bone tamp
US10265122B2 (en) 2013-03-15 2019-04-23 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US9186212B2 (en) 2013-03-15 2015-11-17 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods utilizing two or more sites along denervation catheter
US9775663B2 (en) 2013-03-15 2017-10-03 St. Jude Medical, Cardiology Division, Inc. Ablation system, methods, and controllers
US9974477B2 (en) 2013-03-15 2018-05-22 St. Jude Medical, Cardiology Division, Inc. Quantification of renal denervation via alterations in renal blood flow pre/post ablation
US10098694B2 (en) 2013-04-08 2018-10-16 Apama Medical, Inc. Tissue ablation and monitoring thereof
CN110141177B (zh) 2013-04-08 2021-11-23 阿帕玛医疗公司 消融导管
US10349824B2 (en) 2013-04-08 2019-07-16 Apama Medical, Inc. Tissue mapping and visualization systems
WO2014176205A1 (en) 2013-04-25 2014-10-30 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system
US10548663B2 (en) 2013-05-18 2020-02-04 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods
US10390879B2 (en) 2013-05-20 2019-08-27 Mayo Foundation For Medical Education And Research Devices and methods for ablation of tissue
WO2014188430A2 (en) 2013-05-23 2014-11-27 CardioSonic Ltd. Devices and methods for renal denervation and assessment thereof
JP2016523125A (ja) 2013-05-30 2016-08-08 グラハム エイチ． クリーシー 局所神経性刺激
US11229789B2 (en) 2013-05-30 2022-01-25 Neurostim Oab, Inc. Neuro activator with controller
EP3010435A1 (en) * 2013-06-21 2016-04-27 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
JP2016524949A (ja) * 2013-06-21 2016-08-22 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 回転可能シャフトを有する腎神経アブレーション用医療装置
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US9872728B2 (en) 2013-06-28 2018-01-23 St. Jude Medical, Cardiology Division, Inc. Apparatuses and methods for affixing electrodes to an intravascular balloon
WO2015002787A1 (en) * 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150011991A1 (en) 2013-07-03 2015-01-08 St. Jude Medical, Cardiology Division, Inc. Electrode Assembly For Catheter System
EP3019106A1 (en) * 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
US10660698B2 (en) 2013-07-11 2020-05-26 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation
EP3049007B1 (en) 2013-07-19 2019-06-12 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
US10695124B2 (en) 2013-07-22 2020-06-30 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US20150031946A1 (en) 2013-07-24 2015-01-29 Nidus Medical, Llc Direct vision cryosurgical probe and methods of use
WO2015085162A1 (en) 2013-12-05 2015-06-11 Rfemb Holdings, Llc Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb)
US10154869B2 (en) 2013-08-02 2018-12-18 Gary M. Onik System and method for creating radio-frequency energy electrical membrane breakdown for tissue ablation
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
EP3030182B1 (en) 2013-08-09 2018-01-10 Boston Scientific Scimed, Inc. Expandable catheter
JP6159888B2 (ja) 2013-08-22 2017-07-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経変調バルーンへの接着性を向上させたフレキシブル回路
US20150066118A1 (en) * 2013-08-28 2015-03-05 Medtronic Ardian Luxembourg S.A.R.L. Intravascular Neuromodulation Device Having a Spiral Track and Associated Methods
US9339332B2 (en) 2013-08-30 2016-05-17 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods
US9326816B2 (en) 2013-08-30 2016-05-03 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
US9138578B2 (en) 2013-09-10 2015-09-22 Medtronic Ardian Luxembourg S.A.R.L. Endovascular catheters with tuned control members and associated systems and methods
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
US9687288B2 (en) 2013-09-30 2017-06-27 Arrinex, Inc. Apparatus and methods for treating rhinitis
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
WO2015057521A1 (en) 2013-10-14 2015-04-23 Boston Scientific Scimed, Inc. High resolution cardiac mapping electrode array catheter
EP3057520A1 (en) * 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Medical device balloon
US9770606B2 (en) 2013-10-15 2017-09-26 Boston Scientific Scimed, Inc. Ultrasound ablation catheter with cooling infusion and centering basket
JP6259099B2 (ja) 2013-10-18 2018-01-10 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 可撓性を備える導電性ワイヤを備えるバルーン・カテーテル、並びに関連する使用および製造方法
US20150112234A1 (en) * 2013-10-18 2015-04-23 Medtronic Ardian Luxembourg S.a.r.I Devices, systems, and methods for the selective positioning of an intravascular ultrasound neuromodulation device
USD747491S1 (en) 2013-10-23 2016-01-12 St. Jude Medical, Cardiology Division, Inc. Ablation generator
USD774043S1 (en) 2013-10-23 2016-12-13 St. Jude Medical, Cardiology Division, Inc. Display screen with graphical user interface for ablation generator
US10433902B2 (en) 2013-10-23 2019-10-08 Medtronic Ardian Luxembourg S.A.R.L. Current control methods and systems
US10856936B2 (en) 2013-10-23 2020-12-08 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including thermoplastic-based struts
USD914883S1 (en) 2013-10-23 2021-03-30 St. Jude Medical, Cardiology Division, Inc. Ablation generator
EP3060151A1 (en) 2013-10-24 2016-08-31 St. Jude Medical, Cardiology Division, Inc. Flexible catheter shaft and method of manufacture
US9913961B2 (en) 2013-10-24 2018-03-13 St. Jude Medical, Cardiology Division, Inc. Flexible catheter shaft and method of manufacture
US10034705B2 (en) 2013-10-24 2018-07-31 St. Jude Medical, Cardiology Division, Inc. High strength electrode assembly for catheter system including novel electrode
US10390881B2 (en) 2013-10-25 2019-08-27 Denervx LLC Cooled microwave denervation catheter with insertion feature
CN105658163B (zh) 2013-10-25 2020-08-18 波士顿科学国际有限公司 去神经柔性电路中的嵌入式热电偶
US9949652B2 (en) 2013-10-25 2018-04-24 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US10517666B2 (en) 2013-10-25 2019-12-31 Ablative Solutions, Inc. Apparatus for effective ablation and nerve sensing associated with denervation
US9931046B2 (en) 2013-10-25 2018-04-03 Ablative Solutions, Inc. Intravascular catheter with peri-vascular nerve activity sensors
US10420604B2 (en) 2013-10-28 2019-09-24 St. Jude Medical, Cardiology Division, Inc. Electrode assembly for catheter system including interlinked struts
US9861433B2 (en) * 2013-11-05 2018-01-09 St. Jude Medical, Cardiology Division, Inc. Helical-shaped ablation catheter and methods of use
US9341864B2 (en) 2013-11-15 2016-05-17 Nexisvision, Inc. Contact lenses having a reinforcing scaffold
WO2015103574A1 (en) 2014-01-06 2015-07-09 Iowa Approach Inc. Apparatus and methods for renal denervation ablation
WO2015103617A1 (en) 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
US20150209107A1 (en) 2014-01-24 2015-07-30 Denervx LLC Cooled microwave denervation catheter configuration
EP4059563B1 (en) 2014-01-27 2023-09-27 Medtronic Ireland Manufacturing Unlimited Company Neuromodulation catheters having jacketed neuromodulation elements and related devices
WO2015116559A1 (en) 2014-01-29 2015-08-06 Nexisvision, Inc. Multifocal bimodulus contact lenses
EP3102136B1 (en) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US10555746B2 (en) 2014-02-04 2020-02-11 Hologic, Inc. Devices and methods for treating conditions caused by affarent nerve signals
US11000679B2 (en) 2014-02-04 2021-05-11 Boston Scientific Scimed, Inc. Balloon protection and rewrapping devices and related methods of use
US10492842B2 (en) 2014-03-07 2019-12-03 Medtronic Ardian Luxembourg S.A.R.L. Monitoring and controlling internally administered cryotherapy
US10463424B2 (en) 2014-03-11 2019-11-05 Medtronic Ardian Luxembourg S.A.R.L. Catheters with independent radial-expansion members and associated devices, systems, and methods
US9579149B2 (en) 2014-03-13 2017-02-28 Medtronic Ardian Luxembourg S.A.R.L. Low profile catheter assemblies and associated systems and methods
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10398501B2 (en) 2014-04-24 2019-09-03 St. Jude Medical, Cardiology Division, Inc. Ablation systems including pulse rate detector and feedback mechanism and methods of use
JP2017513600A (ja) 2014-04-24 2017-06-01 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 編組シャフトを有する神経調節カテーテル及び関連システム及び方法
US10610292B2 (en) 2014-04-25 2020-04-07 Medtronic Ardian Luxembourg S.A.R.L. Devices, systems, and methods for monitoring and/or controlling deployment of a neuromodulation element within a body lumen and related technology
US10918840B2 (en) * 2014-05-06 2021-02-16 Hydra Vascular Llc Drug device electroporation system
EP4238521A3 (en) 2014-05-07 2023-11-29 Farapulse, Inc. Methods and apparatus for selective tissue ablation
US10478249B2 (en) 2014-05-07 2019-11-19 Pythagoras Medical Ltd. Controlled tissue ablation techniques
US10709490B2 (en) 2014-05-07 2020-07-14 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies comprising a direct heating element for renal neuromodulation and associated systems and methods
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
AU2015258956B2 (en) * 2014-05-16 2018-11-15 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for modulating renal nerve tissue
EP3145425A4 (en) 2014-05-22 2018-02-14 Aegea Medical, Inc. Systems and methods for performing endometrial ablation
US10179019B2 (en) 2014-05-22 2019-01-15 Aegea Medical Inc. Integrity testing method and apparatus for delivering vapor to the uterus
WO2015179837A1 (en) 2014-05-23 2015-11-26 Amphora Medical, Inc. Methods and devices for treating pelvic conditions
WO2015192027A1 (en) 2014-06-12 2015-12-17 Iowa Approach Inc. Method and apparatus for rapid and selective transurethral tissue ablation
WO2015192018A1 (en) 2014-06-12 2015-12-17 Iowa Approach Inc. Method and apparatus for rapid and selective tissue ablation with cooling
US9763743B2 (en) 2014-07-25 2017-09-19 Arrinex, Inc. Apparatus and method for treating rhinitis
US11154712B2 (en) 2014-08-28 2021-10-26 Medtronic Ardian Luxembourg S.A.R.L. Methods for assessing efficacy of renal neuromodulation and associated systems and devices
KR102033760B1 (ko) * 2014-09-23 2019-10-17 주식회사 한독칼로스메디칼 카테터 및 그 제조 방법
KR102033759B1 (ko) * 2014-09-23 2019-10-17 주식회사 한독칼로스메디칼 카테터 및 그 제조 방법
EP3791817A1 (en) 2014-10-01 2021-03-17 Medtronic Ardian Luxembourg S.à.r.l. Systems for evaluating neuromodulation therapy via hemodynamic responses
EP3206613B1 (en) 2014-10-14 2019-07-03 Farapulse, Inc. Apparatus for rapid and safe pulmonary vein cardiac ablation
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
WO2016075536A2 (en) 2014-11-14 2016-05-19 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems and methods
SG11201703943VA (en) 2014-11-19 2017-06-29 Advanced Cardiac Therapeutics Inc Ablation devices, systems and methods of using a high-resolution electrode assembly
EP3220844B1 (en) 2014-11-19 2020-11-11 EPiX Therapeutics, Inc. Systems for high-resolution mapping of tissue
JP6673598B2 (ja) 2014-11-19 2020-03-25 エピックス セラピューティクス，インコーポレイテッド ペーシングを伴う組織の高分解能マッピング
JP6815998B2 (ja) 2014-12-03 2021-01-20 パブメド インク． 繊維構造の経皮分裂のためのシステム及び方法
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10667736B2 (en) 2014-12-17 2020-06-02 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing sympathetic nervous system tone for neuromodulation therapy
JP6723249B2 (ja) 2015-01-30 2020-07-15 アールエフイーエムビー ホールディングス リミテッド ライアビリティ カンパニー 軟部組織を切除するためのシステムおよび方法
US10376308B2 (en) 2015-02-05 2019-08-13 Axon Therapies, Inc. Devices and methods for treatment of heart failure by splanchnic nerve ablation
US11077301B2 (en) 2015-02-21 2021-08-03 NeurostimOAB, Inc. Topical nerve stimulator and sensor for bladder control
US9636164B2 (en) 2015-03-25 2017-05-02 Advanced Cardiac Therapeutics, Inc. Contact sensing systems and methods
US10383685B2 (en) 2015-05-07 2019-08-20 Pythagoras Medical Ltd. Techniques for use with nerve tissue
CA2984207A1 (en) 2015-05-12 2016-11-17 National University Of Ireland Galway Devices for therapeutic nasal neuromodulation and associated methods and systems
CN114209420A (zh) 2015-10-07 2022-03-22 梅约医学教育与研究基金会 用于肥胖症或糖尿病治疗的电穿孔
WO2017087549A1 (en) 2015-11-16 2017-05-26 Apama Medical, Inc. Energy delivery devices
US10660702B2 (en) 2016-01-05 2020-05-26 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10130423B1 (en) 2017-07-06 2018-11-20 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10172673B2 (en) 2016-01-05 2019-01-08 Farapulse, Inc. Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
US20170189097A1 (en) 2016-01-05 2017-07-06 Iowa Approach Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
US10624554B2 (en) * 2016-01-14 2020-04-21 Biosense Webster (Israel) Ltd. Non-overlapping loop-type or spline-type catheter to determine activation source direction and activation source type
US11006887B2 (en) 2016-01-14 2021-05-18 Biosense Webster (Israel) Ltd. Region of interest focal source detection using comparisons of R-S wave magnitudes and LATs of RS complexes
CN109069624A (zh) 2016-01-15 2018-12-21 瑞美控股有限责任公司 癌症的免疫治疗
KR20170089069A (ko) * 2016-01-25 2017-08-03 에스케이하이닉스 주식회사 메모리 시스템 및 그의 동작방법
JP7125349B2 (ja) 2016-02-11 2022-08-24 アリネックス， インコーポレイテッド 画像誘導後鼻神経アブレーションの方法およびデバイス
EP3416551B1 (en) 2016-02-19 2022-10-12 Aegea Medical Inc. Apparatus for determining the integrity of a bodily cavity
CA3017269A1 (en) 2016-03-15 2017-09-21 Epix Therapeutics, Inc. Improved devices, systems and methods for irrigated ablation
US10736692B2 (en) 2016-04-28 2020-08-11 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation and associated systems and methods for the treatment of cancer
US11678932B2 (en) 2016-05-18 2023-06-20 Symap Medical (Suzhou) Limited Electrode catheter with incremental advancement
CN107440788A (zh) * 2016-06-01 2017-12-08 四川锦江电子科技有限公司 一种具有极间放电功能的消融导管及消融装置
US10524859B2 (en) * 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CN109600988B (zh) 2016-06-15 2021-08-31 阿里内克斯股份有限公司 用于治疗鼻腔外侧表面的装置和方法
WO2017218734A1 (en) 2016-06-16 2017-12-21 Iowa Approach, Inc. Systems, apparatuses, and methods for guide wire delivery
WO2017223264A1 (en) 2016-06-23 2017-12-28 St. Jude Medical, Cardiology Division, Inc. Catheter system and electrode assembly for intraprocedural evaluation of renal denervation
CN114711957A (zh) 2016-07-29 2022-07-08 阿克松疗法公司 通过脏神经消融术治疗心脏衰竭的装置、系统和方法
US11259859B2 (en) 2016-09-07 2022-03-01 Deepqure Inc. Systems and methods for renal denervation
US11253312B2 (en) 2016-10-17 2022-02-22 Arrinex, Inc. Integrated nasal nerve detector ablation-apparatus, nasal nerve locator, and methods of use
US10231784B2 (en) 2016-10-28 2019-03-19 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics
WO2018089795A1 (en) 2016-11-10 2018-05-17 Qoravita LLC System and method for applying a low frequency magnetic field to biological tissues
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US10646713B2 (en) 2017-02-22 2020-05-12 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for treating patients via renal neuromodulation to reduce a risk of developing cognitive impairment
US20200094080A1 (en) 2017-03-20 2020-03-26 Sonivie Ltd. Method for treating heart failure by improving ejection fraction of a patient
CN110809448B (zh) 2017-04-27 2022-11-25 Epix疗法公司 确定导管尖端与组织之间接触的性质
US9987081B1 (en) 2017-04-27 2018-06-05 Iowa Approach, Inc. Systems, devices, and methods for signal generation
US11278356B2 (en) 2017-04-28 2022-03-22 Arrinex, Inc. Systems and methods for locating blood vessels in the treatment of rhinitis
US10617867B2 (en) 2017-04-28 2020-04-14 Farapulse, Inc. Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue
US11707312B2 (en) * 2017-06-19 2023-07-25 St. Jude Medical, Cardiology Division, Inc. Apparatuses and methods for cooling tissue or fluid
US11116564B2 (en) 2017-07-05 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating anxiety disorders in patients via renal neuromodulation
AU2018204842B2 (en) 2017-07-05 2023-07-27 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating depression in patients via renal neuromodulation
US11160982B2 (en) 2017-07-05 2021-11-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating post-traumatic stress disorder in patients via renal neuromodulation
TWI638639B (zh) * 2017-08-11 2018-10-21 奇翼醫電股份有限公司 生理信號量測系統及生理信號量測方法
EP3681391A1 (en) 2017-09-12 2020-07-22 Farapulse, Inc. Systems, apparatuses, and methods for ventricular focal ablation
JP2021510608A (ja) 2017-11-07 2021-04-30 ニューロスティム オーエービー インコーポレイテッド 適応回路を有する非侵襲性神経アクティベーター
CN111511302A (zh) 2017-11-17 2020-08-07 美敦力Af卢森堡有限责任公司 用于具有增强的神经靶向的神经调节的系统、设备以及相关联的方法
US20190159835A1 (en) * 2017-11-29 2019-05-30 Atricure, Inc. Cryopad
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US10561461B2 (en) 2017-12-17 2020-02-18 Axon Therapies, Inc. Methods and devices for endovascular ablation of a splanchnic nerve
CN111683613A (zh) * 2017-12-26 2020-09-18 盖乐世公司 用于各种应用的能量输送的优化
US10959669B2 (en) 2018-01-24 2021-03-30 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing the efficacy of neuromodulation therapy
US11253189B2 (en) 2018-01-24 2022-02-22 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and methods for evaluating neuromodulation therapy via detection of magnetic fields
US11478298B2 (en) 2018-01-24 2022-10-25 Medtronic Ardian Luxembourg S.A.R.L. Controlled irrigation for neuromodulation systems and associated methods
US10786306B2 (en) 2018-01-24 2020-09-29 Medtronic Ardian Luxembourg S.A.R.L. Denervation therapy
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
US20190223946A1 (en) 2018-01-24 2019-07-25 Medtronic Ardian Luxembourg S.A.R.L. Systems, devices, and associated methods for neuromodulation in heterogeneous tissue environments
CN111886043B (zh) 2018-01-26 2024-03-29 阿克松疗法公司 用于内脏神经血管内消融的方法和装置
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
CN110270225B (zh) 2018-03-13 2023-04-07 Bl 科技公司 用于高浓度酸或碱生产的多级双极电渗析系统
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
JP2021522903A (ja) 2018-05-07 2021-09-02 ファラパルス，インコーポレイテッド 組織へアブレーションエネルギーを送達するためのシステム、装置、および方法
CN116327352A (zh) 2018-05-07 2023-06-27 波士顿科学医学有限公司 心外膜消融导管
WO2019217317A1 (en) 2018-05-07 2019-11-14 Farapulse, Inc. Systems, apparatuses, and methods for filtering high voltage noise induced by pulsed electric field ablation
US11413084B2 (en) 2018-07-03 2022-08-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating eating disorders in patients via renal neuromodulation
US10849685B2 (en) 2018-07-18 2020-12-01 Ablative Solutions, Inc. Peri-vascular tissue access catheter with locking handle
US11553960B2 (en) 2018-07-31 2023-01-17 Medtronic Ardian Luxembourg S.A.R.L. Methods for treating patients with catheter-based renal neuromodulation
DE102018120761A1 (de) * 2018-08-24 2020-02-27 Biotronik Se & Co. Kg Elektrodenleitung mit integriertem Deformationssensor
US11633120B2 (en) 2018-09-04 2023-04-25 Medtronic Ardian Luxembourg S.A.R.L. Systems and methods for assessing efficacy of renal neuromodulation therapy
JP2022501112A (ja) 2018-09-20 2022-01-06 ファラパルス，インコーポレイテッド 心内膜組織へのパルス電界アブレーションエネルギーの送達のためのシステム、装置、および方法
EP4241836A3 (en) 2019-06-20 2023-11-29 Axon Therapies, Inc. Devices for endovascular ablation of a splanchnic nerve
JP2022538419A (ja) 2019-06-26 2022-09-02 ニューロスティム テクノロジーズ エルエルシー 適応回路を備えた非侵襲性神経活性化装置
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
CA3150339A1 (en) 2019-09-12 2021-03-18 Brian W. Donovan TISSUE MODULATION SYSTEMS AND METHODS
US10625080B1 (en) 2019-09-17 2020-04-21 Farapulse, Inc. Systems, apparatuses, and methods for detecting ectopic electrocardiogram signals during pulsed electric field ablation
US11497541B2 (en) 2019-11-20 2022-11-15 Boston Scientific Scimed, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US11065047B2 (en) 2019-11-20 2021-07-20 Farapulse, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US10842572B1 (en) 2019-11-25 2020-11-24 Farapulse, Inc. Methods, systems, and apparatuses for tracking ablation devices and generating lesion lines
EP4017580A4 (en) 2019-12-16 2023-09-06 Neurostim Technologies LLC NON-INVASIVE NERVE ACTIVATOR WITH AMPLIFIED CHARGE DISTRIBUTION
EP4209191A1 (en) 2020-01-17 2023-07-12 Axon Therapies, Inc. Catheter and computer for calculation of accumulated volume of liquid delivered into a patient
US11007001B1 (en) * 2020-04-07 2021-05-18 Sonivie Ltd. Devices and methods for reducing parasympathetic nerve activity in patients with a respiratory syndrome
US20210378734A1 (en) 2020-06-04 2021-12-09 Biosense Webster (Israel) Ltd. Smooth-edge and equidistantly spaced electrodes on an expandable frame of a catheter for irreversible-electroporation (ire)
EP4108197A1 (en) 2021-06-24 2022-12-28 Gradient Denervation Technologies Systems for treating tissue

Family Cites Families (1181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2130758A (en) 1935-06-01 1938-09-20 E J Rose Mfg Company Of Califo Electrode for diathermy treatment and the like
US2276995A (en) 1938-01-22 1942-03-17 A J Ginsberg Electrotherapy
US2276996A (en) 1940-11-30 1942-03-17 A J Ginsberg Non-radio-interfering therapeutic apparatus
US2701559A (en) 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US3181535A (en) 1957-10-04 1965-05-04 Diapulse Mfg Corp Of America Athermapeutic apparatus
US3043310A (en) 1959-04-24 1962-07-10 Diapulse Mfg Corp Of America Treatment head for athermapeutic apparatus
US3127895A (en) 1962-07-02 1964-04-07 Dynapower System Corp Therapeutic pulse generation and control circuit
US3270746A (en) 1963-08-26 1966-09-06 Dynapower Systems Corp High-performance electrotherapeutic treatment head
US3329149A (en) 1964-10-28 1967-07-04 Dynapower Systems Corp Of Cali Supporting arm for electrotherapeutic treatment head
US3563246A (en) 1967-04-24 1971-02-16 Intelectron Corp Method and apparatus for improving neural performance in human subjects by electrotherapy
US3522811A (en) 1969-02-13 1970-08-04 Medtronic Inc Implantable nerve stimulator and method of use
SE346468B (zh) 1969-02-24 1972-07-10 Lkb Medical Ab
US3670737A (en) 1970-07-02 1972-06-20 Diapulse Corp Of America Ultra-short wave athermapeutic apparatus
US3760812A (en) 1971-03-19 1973-09-25 Univ Minnesota Implantable spiral wound stimulation electrodes
US3774620A (en) 1971-06-14 1973-11-27 Nemectron Gmbh Electromedicinal apparatus for interference current therapy
US3895639A (en) 1971-09-07 1975-07-22 Rodler Ing Hans Apparatus for producing an interference signal at a selected location
US3800802A (en) 1972-01-07 1974-04-02 Int Medical Electronics Ltd Short-wave therapy apparatus
US3794022A (en) 1972-06-30 1974-02-26 E Nawracaj Dual oscillator, variable pulse duration electrotherapeutic device
US3803463A (en) 1972-07-10 1974-04-09 J Cover Weapon for immobilization and capture
US3897789A (en) 1973-09-13 1975-08-05 Stanley J Blanchard Acupuncture apparatus
US3894532A (en) 1974-01-17 1975-07-15 Acupulse Inc Instruments for transcutaneous and subcutaneous investigation and treatment
US3911930A (en) 1974-03-01 1975-10-14 Stimulation Tech Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation
US4011861A (en) 1974-04-03 1977-03-15 Case Western Reserve University Implantable electric terminal for organic tissue
US4055190A (en) 1974-12-19 1977-10-25 Michio Tany Electrical therapeutic apparatus
US3952751A (en) 1975-01-08 1976-04-27 W. Denis Kendall High-performance electrotherapeutic apparatus
US4026300A (en) 1975-03-14 1977-05-31 Liberty Mutual Method and apparatus for interfacing to nerves
US3987790A (en) 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4266532A (en) 1976-11-17 1981-05-12 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4315503A (en) 1976-11-17 1982-02-16 Electro-Biology, Inc. Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
US4105017A (en) 1976-11-17 1978-08-08 Electro-Biology, Inc. Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment
US4071033A (en) 1976-12-20 1978-01-31 Nawracaj Edward P Electrotherapeutic device with modulated dual signals
US4141365A (en) 1977-02-24 1979-02-27 The Johns Hopkins University Epidural lead electrode and insertion needle
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4305115A (en) 1979-03-14 1981-12-08 Harry H. Leveen Electrostatic shield
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US4405305A (en) 1980-10-27 1983-09-20 University Of Utah Research Foundation Subcutaneous peritoneal injection catheter
US4379462A (en) 1980-10-29 1983-04-12 Neuromed, Inc. Multi-electrode catheter assembly for spinal cord stimulation
CS226514B1 (en) 1981-01-28 1984-04-16 Petr Ing Csc Slovak Apparatus for stimulating live tissues
US4454883A (en) 1982-02-16 1984-06-19 Therafield Holdings Limited Electrotherapeutic apparatus
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
US4467808A (en) 1982-09-17 1984-08-28 Biolectron, Inc. Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
FR2541902B1 (fr) 1983-03-04 1986-02-07 Cofrem International Sa Appareil therapeutique athermique
US4784132A (en) 1983-03-25 1988-11-15 Fox Kenneth R Method of and apparatus for laser treatment of body lumens
US4531943A (en) 1983-08-08 1985-07-30 Angiomedics Corporation Catheter with soft deformable tip
WO1985001213A1 (en) 1983-09-14 1985-03-28 Jacob Zabara Neurocybernetic prosthesis
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4816016A (en) 1984-03-16 1989-03-28 Pudenz-Schulte Medical Research Corp. Subcutaneous infusion reservoir and pump system
US4587975A (en) 1984-07-02 1986-05-13 Cardiac Pacemakers, Inc. Dimension sensitive angioplasty catheter
US4674482A (en) 1984-09-12 1987-06-23 Irt, Inc. Pulse electro-magnetic field therapy device with auto bias circuit
US4608985A (en) 1984-10-11 1986-09-02 Case Western Reserve University Antidromic pulse generating wave form for collision blocking
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US20020045811A1 (en) 1985-03-22 2002-04-18 Carter Kittrell Laser ablation process and apparatus
US5693043A (en) 1985-03-22 1997-12-02 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5034010A (en) 1985-03-22 1991-07-23 Massachusetts Institute Of Technology Optical shield for a laser catheter
US4862886A (en) 1985-05-08 1989-09-05 Summit Technology Inc. Laser angioplasty
US4641649A (en) 1985-10-30 1987-02-10 Rca Corporation Method and apparatus for high frequency catheter ablation
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US4709698A (en) * 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US5014699A (en) 1986-05-23 1991-05-14 Trustees Of The University Of Pennsylvania Electromagnetic method and apparatus for healing living tissue
US4998532A (en) 1986-05-23 1991-03-12 Lti Biomedical, Inc. Portable electro-therapy system
US4715852A (en) 1986-07-21 1987-12-29 Eaton Corporation Implanted medication infusion device
US4774967A (en) 1986-09-09 1988-10-04 American Biointerface Corporation Method and apparatus for mammalian nerve regeneration
US4940064A (en) 1986-11-14 1990-07-10 Desai Jawahar M Catheter for mapping and ablation and method therefor
US4790310A (en) 1987-02-04 1988-12-13 Robert Ginsburg Laser catheter having wide angle sweep
US4770653A (en) 1987-06-25 1988-09-13 Medilase, Inc. Laser angioplasty
US4791931A (en) 1987-08-13 1988-12-20 Pacesetter Infusion, Ltd. Demand pacemaker using an artificial baroreceptor reflex
US4938766A (en) 1987-08-28 1990-07-03 Jarvik Robert K Prosthetic compliance devices
US4852573A (en) 1987-12-04 1989-08-01 Kennedy Philip R Implantable neural electrode
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
EP0398960B1 (en) 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
US4890623A (en) 1988-03-14 1990-01-02 C. R. Bard, Inc. Biopotential sensing device and method for making
US5372138A (en) 1988-03-21 1994-12-13 Boston Scientific Corporation Acousting imaging catheters and the like
CA1319174C (en) 1988-04-21 1993-06-15 Lawrence E. Bertolucci Electrical nerve stimulation device for nausea control
US5178620A (en) 1988-06-10 1993-01-12 Advanced Angioplasty Products, Inc. Thermal dilatation catheter and method
DE68922497T2 (de) 1988-08-24 1995-09-14 Marvin J Slepian Endoluminale dichtung mit bisdegradierbaren polymeren.
US6066130A (en) 1988-10-24 2000-05-23 The General Hospital Corporation Delivering laser energy
US4955377A (en) 1988-10-28 1990-09-11 Lennox Charles D Device and method for heating tissue in a patient's body
US5094242A (en) 1988-11-07 1992-03-10 Regents Of The University Of California Implantable nerve stimulation device
US5150717A (en) 1988-11-10 1992-09-29 Arye Rosen Microwave aided balloon angioplasty with guide filament
US5057318A (en) 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5059423A (en) 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5749914A (en) 1989-01-06 1998-05-12 Advanced Coronary Intervention Catheter for obstructed stent
AU4945490A (en) 1989-01-06 1990-08-01 Angioplasty Systems Inc. Electrosurgical catheter for resolving atherosclerotic plaque
US5458631A (en) 1989-01-06 1995-10-17 Xavier; Ravi Implantable catheter with electrical pulse nerve stimulators and drug delivery system
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
US5453091A (en) 1989-03-17 1995-09-26 Merit Medical Systems, Inc. RF transmission module for wirelessly transmitting balloon catheter data in a syringe inflation system
US5078717A (en) 1989-04-13 1992-01-07 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5125928A (en) 1989-04-13 1992-06-30 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5006119A (en) 1989-05-25 1991-04-09 Engineering & Research Associates, Inc. Hollow core coaxial catheter
US20030220521A1 (en) 1989-07-27 2003-11-27 G.D. Searle & Co. Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension
US5071424A (en) 1989-08-18 1991-12-10 Evi Corporation Catheter atherotome
US5211651A (en) 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5282484A (en) 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
US5156610A (en) 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
ES2079483T3 (es) 1989-08-18 1996-01-16 Evi Corp Aterotomo cateter.
US5662701A (en) 1989-08-18 1997-09-02 Endovascular Instruments, Inc. Anti-stenotic method and product for occluded and partially occluded arteries
CA2067110C (en) 1989-09-08 2001-07-31 John E. Abele Physiologic low stress angioplasty
US5112614A (en) 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5109859A (en) 1989-10-04 1992-05-05 Beth Israel Hospital Association Ultrasound guided laser angioplasty
RU1785710C (en) 1989-10-06 1993-01-07 Vremennyj Nauchnyj Kollektiv O Microwave resonant therapeutic device
US4979511A (en) 1989-11-03 1990-12-25 Cyberonics, Inc. Strain relief tether for implantable electrode
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5344395A (en) 1989-11-13 1994-09-06 Scimed Life Systems, Inc. Apparatus for intravascular cavitation or delivery of low frequency mechanical energy
US5074871A (en) 1989-12-07 1991-12-24 Evi Corporation Catheter atherotome
US5178625A (en) 1989-12-07 1993-01-12 Evi Corporation Catheter atherotome
US5851206A (en) 1990-03-13 1998-12-22 The Regents Of The University Of California Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment
US5098429A (en) 1990-04-17 1992-03-24 Mmtc, Inc. Angioplastic technique employing an inductively-heated ferrite material
US5193048A (en) 1990-04-27 1993-03-09 Kaufman Dennis R Stun gun with low battery indicator and shutoff timer
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5092841A (en) 1990-05-17 1992-03-03 Wayne State University Method for treating an arterial wall injured during angioplasty
US5184617A (en) 1990-06-05 1993-02-09 Staodyn, Inc. Output pulse compensation for therapeutic-type electronic devices
US5095905A (en) 1990-06-07 1992-03-17 Medtronic, Inc. Implantable neural electrode
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
US5498238A (en) 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5499971A (en) 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
EP0533816B1 (en) 1990-06-15 1995-06-14 Cortrak Medical, Inc. Drug delivery apparatus
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5058584A (en) 1990-08-30 1991-10-22 Medtronic, Inc. Method and apparatus for epidural burst stimulation for angina pectoris
US5053033A (en) 1990-10-10 1991-10-01 Boston Advanced Technologies, Inc. Inhibition of restenosis by ultraviolet radiation
US5111815A (en) 1990-10-15 1992-05-12 Cardiac Pacemakers, Inc. Method and apparatus for cardioverter/pacer utilizing neurosensing
US5304171A (en) 1990-10-18 1994-04-19 Gregory Kenton W Catheter devices and methods for delivering
EP0491979A1 (de) 1990-12-22 1992-07-01 Peter Dr. Ing. Osypka Herzschrittmacher-Katheter mit zwei Polen
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5102402A (en) 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5170802A (en) 1991-01-07 1992-12-15 Medtronic, Inc. Implantable electrode for location within a blood vessel
US5997497A (en) 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5304115A (en) 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
US5263480A (en) 1991-02-01 1993-11-23 Cyberonics, Inc. Treatment of eating disorders by nerve stimulation
US5345936A (en) * 1991-02-15 1994-09-13 Cardiac Pathways Corporation Apparatus with basket assembly for endocardial mapping
US5465717A (en) * 1991-02-15 1995-11-14 Cardiac Pathways Corporation Apparatus and Method for ventricular mapping and ablation
US5156151A (en) 1991-02-15 1992-10-20 Cardiac Pathways Corporation Endocardial mapping and ablation system and catheter probe
US5425364A (en) * 1991-02-15 1995-06-20 Cardiac Pathways Corporation Flexible strip assembly without feedthrough holes and device utilizing the same
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5234407A (en) 1991-03-06 1993-08-10 Baxter International Inc. Method and device for exchanging cardiovascular guide catheter while a previously inserted angioplasty guide wire remains in place
US5199428A (en) 1991-03-22 1993-04-06 Medtronic, Inc. Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload
US5454788A (en) 1991-04-24 1995-10-03 Baxter International Inc. Exchangeable integrated-wire balloon catheter
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
US5215086A (en) 1991-05-03 1993-06-01 Cyberonics, Inc. Therapeutic treatment of migraine symptoms by stimulation
US5251634A (en) 1991-05-03 1993-10-12 Cyberonics, Inc. Helical nerve electrode
US5299569A (en) 1991-05-03 1994-04-05 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US6309379B1 (en) 1991-05-23 2001-10-30 Lloyd K. Willard Sheath for selective delivery of multiple intravascular devices and methods of use thereof
US5458568A (en) 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
WO1992020291A1 (en) 1991-05-24 1992-11-26 Applied Medical Resources, Inc. Articulating tissue cutter assembly
US5137727A (en) 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5213098A (en) 1991-07-26 1993-05-25 Medtronic, Inc. Post-extrasystolic potentiation stimulation with physiologic sensor feedback
US5222494A (en) 1991-07-31 1993-06-29 Cyberonics, Inc. Implantable tissue stimulator output stabilization system
US5231988A (en) 1991-08-09 1993-08-03 Cyberonics, Inc. Treatment of endocrine disorders by nerve stimulation
WO1993006780A1 (en) 1991-10-03 1993-04-15 The General Hospital Corporation Apparatus and method for vasodilation
JPH0596012A (ja) 1991-10-07 1993-04-20 Olympus Optical Co Ltd 温熱治療装置
US5215089A (en) 1991-10-21 1993-06-01 Cyberonics, Inc. Electrode assembly for nerve stimulation
DE69233091T2 (de) * 1991-11-08 2004-05-06 Boston Scientific Ltd., St. Michael Ablationselektrode mit isoliertem temperaturmesselement
US5304206A (en) 1991-11-18 1994-04-19 Cyberonics, Inc. Activation techniques for implantable medical device
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5203326A (en) 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
US5498261A (en) 1991-12-20 1996-03-12 Advanced Cardiovascular Systems, Inc. Thermal angioplasty system
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US6179824B1 (en) 1993-05-10 2001-01-30 Arthrocare Corporation System and methods for electrosurgical restenosis of body lumens
US5419767A (en) 1992-01-07 1995-05-30 Thapliyal And Eggers Partners Methods and apparatus for advancing catheters through severely occluded body lumens
EP0558297B1 (en) 1992-02-25 1997-04-16 Japan Crescent Inc. Heated balloon catheter
WO1993018415A1 (en) 1992-03-09 1993-09-16 University Of Washington Image neurography and diffusion anisotropy imaging
US5306250A (en) 1992-04-02 1994-04-26 Indiana University Foundation Method and apparatus for intravascular drug delivery
US5300068A (en) * 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
CA2134071C (en) 1992-04-23 1999-04-27 Sew Wah Tay Apparatus and method for sealing vascular punctures
USRE40863E1 (en) 1992-04-23 2009-07-21 Boston Scientific Scimed, Inc. Apparatus and method for sealing vascular punctures
US6063085A (en) 1992-04-23 2000-05-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5810810A (en) 1992-04-23 1998-09-22 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5562720A (en) 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5277201A (en) 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5443470A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Method and apparatus for endometrial ablation
US5370680A (en) 1992-05-27 1994-12-06 Magnetic Resonance Therapeutics, Inc. Athermapeutic apparatus employing electro-magnetic fields
WO1994000188A1 (en) 1992-06-24 1994-01-06 Cyberonics, Inc. Treatment of neuropsychiatric disorders by nerve stimulation
US5782239A (en) 1992-06-30 1998-07-21 Cordis Webster, Inc. Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire
US5772590A (en) * 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US5304120A (en) 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5507724A (en) 1992-07-01 1996-04-16 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
US5484400A (en) * 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US5542916A (en) 1992-08-12 1996-08-06 Vidamed, Inc. Dual-channel RF power delivery system
DE4229693A1 (de) 1992-09-05 1994-03-10 Achim Dr Hansjuergens Elektrotherapeutisches Gerät
JP3007687B2 (ja) 1992-09-10 2000-02-07 チルドレンズ メディカル センター コーポレイション 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5478303A (en) 1992-09-18 1995-12-26 Foley-Nolan; Darragh Electromagnetic apparatus for use in therapy
US5338662A (en) 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5553611A (en) 1994-01-06 1996-09-10 Endocardial Solutions, Inc. Endocardial measurement method
US5333614A (en) 1992-09-28 1994-08-02 Feiring Andrew J Measurement of absolute vascular flow
US6086581A (en) 1992-09-29 2000-07-11 Ep Technologies, Inc. Large surface cardiac ablation catheter that assumes a low profile during introduction into the heart
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
CA2107741C (en) 1992-10-07 2000-06-27 Peter T. Keith Ablation devices and methods of use
US5687737A (en) 1992-10-09 1997-11-18 Washington University Computerized three-dimensional cardiac mapping with interactive visual displays
US5634901A (en) 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
US5334193A (en) 1992-11-13 1994-08-02 American Cardiac Ablation Co., Inc. Fluid cooled ablation catheter
DE4338758C2 (de) 1992-11-13 2001-08-09 Scimed Life Systems Inc Katheteranordnung
US6923805B1 (en) 1992-11-13 2005-08-02 Scimed Life Systems, Inc. Electrophysiology energy treatment devices and methods of use
US6068653A (en) 1992-11-13 2000-05-30 Scimed Life Systems, Inc. Electrophysiology catheter device
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
CA2109980A1 (en) 1992-12-01 1994-06-02 Mir A. Imran Steerable catheter with adjustable bend location and/or radius and method
US5256141A (en) 1992-12-22 1993-10-26 Nelson Gencheff Biological material deployment method and apparatus
US5317155A (en) 1992-12-29 1994-05-31 The Electrogesic Corporation Corona discharge apparatus
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
ATE178218T1 (de) 1993-02-05 1999-04-15 Joe W And Dorothy Dorsett Brow Ultraschallballonkatheter für angioplastik
US5792187A (en) 1993-02-22 1998-08-11 Angeion Corporation Neuro-stimulation to control pain during cardioversion defibrillation
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US6161543A (en) 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
AU3774193A (en) 1993-02-23 1994-09-14 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
US5397338A (en) 1993-03-29 1995-03-14 Maven Labs, Inc. Electrotherapy device
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
DK0702723T3 (da) 1993-04-21 2003-01-13 Pasteur Institut Biokompatibelt implantat til ekspression og udskillelse af terapeutisk forbindelse in vivo
FR2704151B1 (fr) 1993-04-21 1995-07-13 Klotz Antoine Olivier Dispositif électronique destiné à la stimulation adrénergique du système sympathique relatif à la média veineuse.
US6517811B2 (en) 1993-05-06 2003-02-11 Research Corporation Technologies, Inc. Compounds for cancer imaging and therapy
US5693082A (en) 1993-05-14 1997-12-02 Fidus Medical Technology Corporation Tunable microwave ablation catheter system and method
US5584863A (en) 1993-06-24 1996-12-17 Electropharmacology, Inc. Pulsed radio frequency electrotherapeutic system
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
DE69432148T2 (de) 1993-07-01 2003-10-16 Boston Scient Ltd Katheter zur bilddarstellung, zur anzeige elektrischer signale und zur ablation
US5507791A (en) 1993-08-31 1996-04-16 Sit'ko; Sergei P. Microwave resonance therapy
US5427118A (en) 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
ES2260758T3 (es) * 1993-10-14 2006-11-01 Boston Scientific Limited Elementos de electrodo para formar patrones de lesion.
US5582609A (en) * 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
US5840076A (en) 1996-04-12 1998-11-24 Ep Technologies, Inc. Tissue heating and ablation systems and methods using electrode structures with distally oriented porous regions
US6146379A (en) * 1993-10-15 2000-11-14 Ep Technologies, Inc. Systems and methods for creating curvilinear lesions in body tissue
US5400784A (en) 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
WO1995010320A1 (en) * 1993-10-15 1995-04-20 Ep Technologies, Inc. Device for lengthening cardiac conduction pathways
US5991650A (en) 1993-10-15 1999-11-23 Ep Technologies, Inc. Surface coatings for catheters, direct contacting diagnostic and therapeutic devices
WO1995010319A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Electrodes for creating lesions in body tissue
US6001093A (en) * 1993-10-15 1999-12-14 Ep Technologies, Inc. Systems and methods for creating long, thin lesions in body tissue
US5797903A (en) 1996-04-12 1998-08-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces
US5545193A (en) * 1993-10-15 1996-08-13 Ep Technologies, Inc. Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5575810A (en) * 1993-10-15 1996-11-19 Ep Technologies, Inc. Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like
US5397308A (en) 1993-10-22 1995-03-14 Scimed Life Systems, Inc. Balloon inflation measurement apparatus
US5470352A (en) * 1993-10-29 1995-11-28 Northeastern University Balloon angioplasty device
US5571147A (en) 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5433739A (en) 1993-11-02 1995-07-18 Sluijter; Menno E. Method and apparatus for heating an intervertebral disc for relief of back pain
US5599345A (en) * 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
JPH07157424A (ja) 1993-12-03 1995-06-20 Lintec Corp 局所麻酔用ゲル製剤
US5730127A (en) 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
US5458626A (en) 1993-12-27 1995-10-17 Krause; Horst E. Method of electrical nerve stimulation for acceleration of tissue healing
US5697975A (en) 1994-02-09 1997-12-16 The University Of Iowa Research Foundation Human cerebral cortex neural prosthetic for tinnitus
US6858024B1 (en) 1994-02-14 2005-02-22 Scimed Life Systems, Inc. Guide catheter having selected flexural modulus segments
US5588962A (en) 1994-03-29 1996-12-31 Boston Scientific Corporation Drug treatment of diseased sites deep within the body
GB9407135D0 (en) 1994-04-11 1994-06-01 Aberdeen University And Plasma Treatment of osteoporosis
US5505201A (en) 1994-04-20 1996-04-09 Case Western Reserve University Implantable helical spiral cuff electrode
US5451207A (en) 1994-04-25 1995-09-19 The Regents Of The University Of California Method of coronary plaque removal with bypass and perfusion
WO1995033514A1 (en) 1994-06-09 1995-12-14 Magnetic Resonance Therapeutics, Inc. Electro-therapeutic method
US5505700A (en) 1994-06-14 1996-04-09 Cordis Corporation Electro-osmotic infusion catheter
US6315776B1 (en) 1994-06-24 2001-11-13 Vidacare, Inc. Thin layer ablation apparatus
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5505730A (en) 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6056744A (en) 1994-06-24 2000-05-02 Conway Stuart Medical, Inc. Sphincter treatment apparatus
JP3578460B2 (ja) 1994-06-27 2004-10-20 ボストン サイエンティフィック リミテッド 体内の温度を感知するためのシステム及び方法
US5857998A (en) 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5454782A (en) 1994-08-11 1995-10-03 Perkins; Rodney C. Translumenal circumferential energy delivery device
EP0776235A4 (en) 1994-08-17 1999-08-25 Magnetic Resonance Therapeutic ELECTROTHERAPEUTIC SYSTEM
US8025661B2 (en) 1994-09-09 2011-09-27 Cardiofocus, Inc. Coaxial catheter instruments for ablation with radiant energy
US6572609B1 (en) 1999-07-14 2003-06-03 Cardiofocus, Inc. Phototherapeutic waveguide apparatus
US5647847A (en) 1994-09-16 1997-07-15 Scimed Life Systems, Inc. Balloon catheter with improved pressure source
US5531778A (en) 1994-09-20 1996-07-02 Cyberonics, Inc. Circumneural electrode assembly
US5540734A (en) 1994-09-28 1996-07-30 Zabara; Jacob Cranial nerve stimulation treatments using neurocybernetic prosthesis
WO1996011723A1 (en) 1994-10-17 1996-04-25 Australasian Medical Technology Limited Devices and methods for implementation of pulsed electromagnetic field therapy
US5722401A (en) 1994-10-19 1998-03-03 Cardiac Pathways Corporation Endocardial mapping and/or ablation catheter probe
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
US5660848A (en) 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
DE69529572T2 (de) 1994-11-10 2003-06-18 Univ Kentucky Res Foundation L Implantierbare wiederauffüllbare vorrichtung mit gesteuerter freisetzung zur verabreichung von arzneistoffen unmittelbar an einen inneren teil des körpers
US5571150A (en) 1994-12-19 1996-11-05 Cyberonics, Inc. Treatment of patients in coma by nerve stimulation
US5569198A (en) 1995-01-23 1996-10-29 Cortrak Medical Inc. Microporous catheter
US5665062A (en) 1995-01-23 1997-09-09 Houser; Russell A. Atherectomy catheter and RF cutting method
US5695504A (en) 1995-02-24 1997-12-09 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US5904697A (en) 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6110187A (en) 1995-02-24 2000-08-29 Heartport, Inc. Device and method for minimizing heart displacements during a beating heart surgical procedure
US5954664A (en) 1995-04-06 1999-09-21 Seegobin; Ronald D. Noninvasive system and method for identifying coronary disfunction utilizing electrocardiography derived data
WO1996034571A1 (en) 1995-05-04 1996-11-07 Cosman Eric R Cool-tip electrode thermosurgery system
US5540730A (en) 1995-06-06 1996-07-30 Cyberonics, Inc. Treatment of motility disorders by nerve stimulation
US6190379B1 (en) 1995-06-06 2001-02-20 Sun Star Technology, Inc. Hot tip catheter
US5741248A (en) * 1995-06-07 1998-04-21 Temple University-Of The Commonwealth System Of Higher Education Fluorochemical liquid augmented cryosurgery
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
JPH10503964A (ja) 1995-06-07 1998-04-14 ゴア ハイブリッド テクノロジーズ，インコーポレイティド 治療用デバイスのための移植可能な閉じ込め装置並びにその中にそのデバイスを装填及び再装填する方法
CA2195119C (en) 1995-06-09 2001-09-11 Mark Chasin Formulations and methods for providing prolonged local anesthesia
US6322558B1 (en) * 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
EP0835075A4 (en) 1995-06-30 1999-06-23 Boston Scient Corp CATHETER FOR ULTRASONIC IMAGING, WITH A CUTTING ELEMENT
US5865801A (en) 1995-07-18 1999-02-02 Houser; Russell A. Multiple compartmented balloon catheter with external pressure sensing
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
US5672174A (en) * 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5800484A (en) 1995-08-15 1998-09-01 Rita Medical Systems, Inc. Multiple antenna ablation apparatus with expanded electrodes
US5711326A (en) 1995-08-25 1998-01-27 Whirlpool Corporation Dishwasher accumulator soil removal grating for a filter system
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US6763261B2 (en) 1995-09-20 2004-07-13 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6615071B1 (en) 1995-09-20 2003-09-02 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
AU709432B2 (en) 1995-09-20 1999-08-26 California Institute Of Technology Detecting thermal discrepancies in vessel walls
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
US5830222A (en) 1995-10-13 1998-11-03 Transvascular, Inc. Device, system and method for intersititial transvascular intervention
IL151563A0 (en) 1995-10-13 2003-04-10 Transvascular Inc A longitudinal compression apparatus for compressing tissue
US5755750A (en) 1995-11-13 1998-05-26 University Of Florida Method and apparatus for selectively inhibiting activity in nerve fibers
US6073048A (en) 1995-11-17 2000-06-06 Medtronic, Inc. Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
CN2291164Y (zh) 1996-12-23 1998-09-16 祝强 降压仪
US5853411A (en) 1996-01-19 1998-12-29 Ep Technologies, Inc. Enhanced electrical connections for electrode structures
US5830213A (en) 1996-04-12 1998-11-03 Ep Technologies, Inc. Systems for heating and ablating tissue using multifunctional electrode structures
US5891136A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Expandable-collapsible mesh electrode structures
WO1997045156A2 (en) 1996-01-19 1997-12-04 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures
WO1997025918A1 (en) 1996-01-19 1997-07-24 Ep Technologies, Inc. Electrode structures formed from flexible, porous, or woven materials
US6475213B1 (en) 1996-01-19 2002-11-05 Ep Technologies, Inc. Method of ablating body tissue
US5925038A (en) 1996-01-19 1999-07-20 Ep Technologies, Inc. Expandable-collapsible electrode structures for capacitive coupling to tissue
WO1997025917A1 (en) 1996-01-19 1997-07-24 Ep Technologies, Inc. Multi-function electrode structures for electrically analyzing and heating body tissue
US5868736A (en) 1996-04-12 1999-02-09 Ep Technologies, Inc. Systems and methods to control tissue heating or ablation with porous electrode structures
US5846239A (en) 1996-04-12 1998-12-08 Ep Technologies, Inc. Tissue heating and ablation systems and methods using segmented porous electrode structures
US5836874A (en) 1996-04-08 1998-11-17 Ep Technologies, Inc. Multi-function electrode structures for electrically analyzing and heating body tissue
US5879348A (en) 1996-04-12 1999-03-09 Ep Technologies, Inc. Electrode structures formed from flexible, porous, or woven materials
US5871483A (en) 1996-01-19 1999-02-16 Ep Technologies, Inc. Folding electrode structures
US5891135A (en) 1996-01-19 1999-04-06 Ep Technologies, Inc. Stem elements for securing tubing and electrical wires to expandable-collapsible electrode structures
US5961513A (en) 1996-01-19 1999-10-05 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures
US5846238A (en) 1996-01-19 1998-12-08 Ep Technologies, Inc. Expandable-collapsible electrode structures with distal end steering or manipulation
US6071278A (en) 1996-02-28 2000-06-06 Ep Technologies, Inc. Tissue heating and ablation systems and methods using porous electrode structures with specified electrical resistivities
ATE247429T1 (de) 1996-02-02 2003-09-15 Transvascular Inc System für interstitielle transvaskuläre chirurgische eingriffe
RU2189221C2 (ru) 1996-02-02 2002-09-20 Элзэ Копэрейшн Устройство для введения активного вещества (варианты), способ его изготовления и способ лечения пациента, страдающего раком предстательной железы
US5913876A (en) 1996-02-20 1999-06-22 Cardiothoracic Systems, Inc. Method and apparatus for using vagus nerve stimulation in surgery
US6051017A (en) 1996-02-20 2000-04-18 Advanced Bionics Corporation Implantable microstimulator and systems employing the same
US6436056B1 (en) 1996-02-28 2002-08-20 Boston Scientific Corporation Polymeric implements for torque transmission
US6152899A (en) 1996-03-05 2000-11-28 Vnus Medical Technologies, Inc. Expandable catheter having improved electrode design, and method for applying energy
EP0921765B1 (en) 1996-03-05 2007-05-02 Vnus Medical Technologies, Inc. Vascular catheter-based system for heating tissue
US6139527A (en) 1996-03-05 2000-10-31 Vnus Medical Technologies, Inc. Method and apparatus for treating hemorrhoids
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
US6033397A (en) 1996-03-05 2000-03-07 Vnus Medical Technologies, Inc. Method and apparatus for treating esophageal varices
US5843016A (en) 1996-03-18 1998-12-01 Physion S.R.L. Electromotive drug administration for treatment of acute urinary outflow obstruction
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5690681A (en) 1996-03-29 1997-11-25 Purdue Research Foundation Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US7604633B2 (en) 1996-04-12 2009-10-20 Cytyc Corporation Moisture transport system for contact electrocoagulation
US6813520B2 (en) 1996-04-12 2004-11-02 Novacept Method for ablating and/or coagulating tissue using moisture transport
US5769880A (en) * 1996-04-12 1998-06-23 Novacept Moisture transport system for contact electrocoagulation
US6673040B1 (en) 1996-04-16 2004-01-06 Cardeon Corporation System and methods for catheter procedures with circulatory support in high risk patients
US6898454B2 (en) 1996-04-25 2005-05-24 The Johns Hopkins University Systems and methods for evaluating the urethra and the periurethral tissues
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6449507B1 (en) 1996-04-30 2002-09-10 Medtronic, Inc. Method and system for nerve stimulation prior to and during a medical procedure
US6735471B2 (en) 1996-04-30 2004-05-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US7022105B1 (en) 1996-05-06 2006-04-04 Novasys Medical Inc. Treatment of tissue in sphincters, sinuses and orifices
US5690691A (en) 1996-05-08 1997-11-25 The Center For Innovative Technology Gastro-intestinal pacemaker having phased multi-point stimulation
US5938690A (en) 1996-06-07 1999-08-17 Advanced Neuromodulation Systems, Inc. Pain management system and method
US5861021A (en) 1996-06-17 1999-01-19 Urologix Inc Microwave thermal therapy of cardiac tissue
US20020040204A1 (en) 1996-06-24 2002-04-04 Dev Nagendu B. Electroporation-enhanced inhibition of vascular neointimal hyperplasia
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5983141A (en) 1996-06-27 1999-11-09 Radionics, Inc. Method and apparatus for altering neural tissue function
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US6245026B1 (en) 1996-07-29 2001-06-12 Farallon Medsystems, Inc. Thermography catheter
US5924997A (en) 1996-07-29 1999-07-20 Campbell; Thomas Henderson Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body
US6058328A (en) 1996-08-06 2000-05-02 Pacesetter, Inc. Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US5792105A (en) 1996-09-11 1998-08-11 Boston Scientific Corporation Multichannel balloon catheter for delivering fluid
SE9603314D0 (sv) * 1996-09-12 1996-09-12 Siemens Elema Ab Förfarande och anordning för att bestämma läget hos en kateter inuti kroppen hos en patient
US7603166B2 (en) 1996-09-20 2009-10-13 Board Of Regents University Of Texas System Method and apparatus for detection of vulnerable atherosclerotic plaque
US5906636A (en) 1996-09-20 1999-05-25 Texas Heart Institute Heat treatment of inflamed tissue
US5954740A (en) 1996-09-23 1999-09-21 Boston Scientific Corporation Catheter balloon having raised radial segments
US5800464A (en) 1996-10-03 1998-09-01 Medtronic, Inc. System for providing hyperpolarization of cardiac to enhance cardiac function
US5814079A (en) 1996-10-04 1998-09-29 Medtronic, Inc. Cardiac arrhythmia management by application of adnodal stimulation for hyperpolarization of myocardial cells
US5704908A (en) 1996-10-10 1998-01-06 Genetronics, Inc. Electroporation and iontophoresis catheter with porous balloon
US6464697B1 (en) * 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
US6840936B2 (en) * 1996-10-22 2005-01-11 Epicor Medical, Inc. Methods and devices for ablation
US6237605B1 (en) 1996-10-22 2001-05-29 Epicor, Inc. Methods of epicardial ablation
US7052493B2 (en) * 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
US5904651A (en) 1996-10-28 1999-05-18 Ep Technologies, Inc. Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US5848969A (en) 1996-10-28 1998-12-15 Ep Technologies, Inc. Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5827268A (en) 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
US5893885A (en) * 1996-11-01 1999-04-13 Cordis Webster, Inc. Multi-electrode ablation catheter
US6081749A (en) 1997-08-13 2000-06-27 Surx, Inc. Noninvasive devices, methods, and systems for shrinking of tissues
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US5875782A (en) 1996-11-14 1999-03-02 Cardiothoracic Systems, Inc. Methods and devices for minimally invasive coronary artery revascularization on a beating heart without cardiopulmonary bypass
JP2001505100A (ja) 1996-11-21 2001-04-17 ボストン サイエンティフィック コーポレイション 光を利用した粘膜剥離
US5954719A (en) * 1996-12-11 1999-09-21 Irvine Biomedical, Inc. System for operating a RF ablation generator
US6071279A (en) * 1996-12-19 2000-06-06 Ep Technologies, Inc. Branched structures for supporting multiple electrode elements
US5871449A (en) 1996-12-27 1999-02-16 Brown; David Lloyd Device and method for locating inflamed plaque in an artery
US5775338A (en) 1997-01-10 1998-07-07 Scimed Life Systems, Inc. Heated perfusion balloon for reduction of restenosis
EP0948373B1 (en) 1997-01-13 2004-09-01 Neurodan A/S An implantable nerve stimulator electrode
US6026326A (en) 1997-01-13 2000-02-15 Medtronic, Inc. Apparatus and method for treating chronic constipation
US6338726B1 (en) 1997-02-06 2002-01-15 Vidacare, Inc. Treating urinary and other body strictures
EP1007139A4 (en) 1997-02-12 2000-06-14 Prolifix Medical Inc ENDOVASCULAR PROSTHESIS EXTRACTION APPARATUS
EP1006908A2 (en) * 1997-02-12 2000-06-14 Oratec Interventions, Inc. Concave probe for arthroscopic surgery
US5989284A (en) 1997-02-18 1999-11-23 Hearten Medical, Inc. Method and device for soft tissue modification
US6208894B1 (en) 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
AU6667698A (en) 1997-02-26 1998-09-18 Alfred E. Mann Foundation For Scientific Research Battery-powered patient implantable device
US6120516A (en) 1997-02-28 2000-09-19 Lumend, Inc. Method for treating vascular occlusion
US7220257B1 (en) 2000-07-25 2007-05-22 Scimed Life Systems, Inc. Cryotreatment device and method
US5868735A (en) 1997-03-06 1999-02-09 Scimed Life Systems, Inc. Cryoplasty device and method
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
AU6942198A (en) 1997-03-27 1998-10-22 Advanced Bionics, Inc. System of implantable devices for monitoring and/or affecting body para meters
US5954661A (en) * 1997-03-31 1999-09-21 Thomas Jefferson University Tissue characterization and treatment using pacing
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5972026A (en) 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US6634363B1 (en) 1997-04-07 2003-10-21 Broncus Technologies, Inc. Methods of treating lungs having reversible obstructive pulmonary disease
US7027869B2 (en) * 1998-01-07 2006-04-11 Asthmatx, Inc. Method for treating an asthma attack
US6488673B1 (en) 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US7425212B1 (en) 1998-06-10 2008-09-16 Asthmatx, Inc. Devices for modification of airways by transfer of energy
AU744343B2 (en) 1997-04-11 2002-02-21 Transvascular, Inc. Methods and apparatus for transmyocardial direct coronary revascularization
US5948007A (en) 1997-04-30 1999-09-07 Medtronic, Inc. Dual channel implantation neurostimulation techniques
US6723063B1 (en) 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US6326020B1 (en) 1997-05-16 2001-12-04 Children's Medical Center Corporation Local anesthetic formulations
US5989208A (en) 1997-05-16 1999-11-23 Nita; Henry Therapeutic ultrasound system
CN1230120C (zh) 1997-05-23 2005-12-07 普罗里森姆股份有限公司 由mri引导的治疗装置
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
WO1998056324A1 (en) 1997-06-13 1998-12-17 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
US6855143B2 (en) 1997-06-13 2005-02-15 Arthrocare Corporation Electrosurgical systems and methods for recanalization of occluded body lumens
US6161048A (en) 1997-06-26 2000-12-12 Radionics, Inc. Method and system for neural tissue modification
WO1999000060A1 (en) * 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
BR9815499A (pt) 1997-07-02 2001-01-02 Euro Celtique Sa Anestesia prolongada nas juntas e nos espacos corporais.
US6117101A (en) * 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6997925B2 (en) 1997-07-08 2006-02-14 Atrionx, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
JP4000243B2 (ja) 1997-07-08 2007-10-31 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 周辺部切除装置組立体および方法
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6500174B1 (en) * 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6652515B1 (en) 1997-07-08 2003-11-25 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
ATE353689T1 (de) 1997-07-16 2007-03-15 Metacure Nv Einrichtung zur steuerung eines glatten muskels
US9023031B2 (en) 1997-08-13 2015-05-05 Verathon Inc. Noninvasive devices, methods, and systems for modifying tissues
JP2001514921A (ja) 1997-08-13 2001-09-18 サークス， インコーポレイテッド 組織収縮のための非侵襲性デバイス、方法、およびシステム
US6200312B1 (en) 1997-09-11 2001-03-13 Vnus Medical Technologies, Inc. Expandable vein ligator catheter having multiple electrode leads
US6401719B1 (en) 1997-09-11 2002-06-11 Vnus Medical Technologies, Inc. Method of ligating hollow anatomical structures
US6179832B1 (en) 1997-09-11 2001-01-30 Vnus Medical Technologies, Inc. Expandable catheter having two sets of electrodes
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6238389B1 (en) 1997-09-30 2001-05-29 Boston Scientific Corporation Deflectable interstitial ablation device
JP4239409B2 (ja) 1997-10-08 2009-03-18 株式会社カネカ バルーンカテーテル及びその製造方法
US5971979A (en) 1997-12-02 1999-10-26 Odyssey Technologies, Inc. Method for cryogenic inhibition of hyperplasia
US6917834B2 (en) 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
AU2022999A (en) 1997-12-31 1999-07-19 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6146380A (en) 1998-01-09 2000-11-14 Radionics, Inc. Bent tip electrical surgical probe
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
CA2295134A1 (en) 1998-01-15 1999-07-22 Amethyst Technologies, Inc. Improved pulsed electromagnetic energy treatment apparatus and method
US6251130B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Device for applications of selective organ cooling
US6415187B1 (en) 1998-02-10 2002-07-02 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and insertion needle for use therewith
US6522932B1 (en) 1998-02-10 2003-02-18 Advanced Bionics Corporation Implantable, expandable, multicontact electrodes and tools for use therewith
US6205361B1 (en) 1998-02-10 2001-03-20 Advanced Bionics Corporation Implantable expandable multicontact electrodes
US6517534B1 (en) 1998-02-11 2003-02-11 Cosman Company, Inc. Peri-urethral ablation
US6447505B2 (en) 1998-02-11 2002-09-10 Cosman Company, Inc. Balloon catheter method for intra-urethral radio-frequency urethral enlargement
US6651670B2 (en) 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US6273886B1 (en) * 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6355031B1 (en) * 1998-02-19 2002-03-12 Curon Medical, Inc. Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter
CA2319517A1 (en) * 1998-02-19 1999-08-26 Curon Medical, Inc. Electrosurgical sphincter treatment apparatus
US6358245B1 (en) * 1998-02-19 2002-03-19 Curon Medical, Inc. Graphical user interface for association with an electrode structure deployed in contact with a tissue region
US6402744B2 (en) * 1998-02-19 2002-06-11 Curon Medical, Inc. Systems and methods for forming composite lesions to treat dysfunction in sphincters and adjoining tissue regions
US6423058B1 (en) * 1998-02-19 2002-07-23 Curon Medical, Inc. Assemblies to visualize and treat sphincters and adjoining tissue regions
US7165551B2 (en) 1998-02-19 2007-01-23 Curon Medical, Inc. Apparatus to detect and treat aberrant myoelectric activity
US6645201B1 (en) * 1998-02-19 2003-11-11 Curon Medical, Inc. Systems and methods for treating dysfunctions in the intestines and rectum
US6258087B1 (en) * 1998-02-19 2001-07-10 Curon Medical, Inc. Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6325798B1 (en) * 1998-02-19 2001-12-04 Curon Medical, Inc. Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions
US7329254B2 (en) * 1998-02-19 2008-02-12 Curon Medical, Inc. Systems and methods for treating dysfunctions in the intestines and rectum that adapt to the anatomic form and structure of different individuals
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
CA2321671C (en) 1998-03-02 2009-07-14 Atrionix, Inc. Tissue ablation system and method for forming long linear lesion
US6096021A (en) 1998-03-30 2000-08-01 The University Of Virginia Patent Foundation Flow arrest, double balloon technique for occluding aneurysms or blood vessels
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
AU3212199A (en) 1998-03-31 1999-10-18 Scimed Life Systems, Inc. Temperature controlled solute delivery system
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US7001378B2 (en) 1998-03-31 2006-02-21 Innercool Therapies, Inc. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6086527A (en) 1998-04-02 2000-07-11 Scimed Life Systems, Inc. System for treating congestive heart failure
US6314325B1 (en) * 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6666874B2 (en) 1998-04-10 2003-12-23 Endicor Medical, Inc. Rotational atherectomy system with serrated cutting tip
JP2003511098A (ja) 1998-04-14 2003-03-25 ジーエムピー・ドラツグ・デリバリー・インコーポレーテツド 動脈及び他の身体組織への局所的薬物移送のためのイオン導入、エレクトロポレーション及び組み合わせカテーテル
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6364856B1 (en) 1998-04-14 2002-04-02 Boston Scientific Corporation Medical device with sponge coating for controlled drug release
US5916154A (en) 1998-04-22 1999-06-29 Nellcor Puritan Bennett Method of enhancing performance in pulse oximetry via electrical stimulation
US20020065542A1 (en) 1998-04-22 2002-05-30 Ronald G. Lax Method and apparatus for treating an aneurysm
US6269269B1 (en) 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US5928272A (en) 1998-05-02 1999-07-27 Cyberonics, Inc. Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity
US6192889B1 (en) 1998-05-05 2001-02-27 Woodside Biomedical, Inc. Method of suppression and prevention of the gag reflex
US6059778A (en) 1998-05-05 2000-05-09 Cardiac Pacemakers, Inc. RF ablation apparatus and method using unipolar and bipolar techniques
AU3973599A (en) 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
US6231572B1 (en) 1998-05-29 2001-05-15 Applied Medical Resources Corporation Electrosurgical catheter apparatus and method
US7198635B2 (en) 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6322559B1 (en) * 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
CA2337652C (en) 1998-07-13 2013-03-26 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6394096B1 (en) 1998-07-15 2002-05-28 Corazon Technologies, Inc. Method and apparatus for treatment of cardiovascular tissue mineralization
US7599736B2 (en) 2001-07-23 2009-10-06 Dilorenzo Biomedical, Llc Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6304787B1 (en) 1998-08-26 2001-10-16 Advanced Bionics Corporation Cochlear electrode array having current-focusing and tissue-treating features
US20050080374A1 (en) 1998-09-01 2005-04-14 Brady Esch Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion
US6123702A (en) 1998-09-10 2000-09-26 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US7722539B2 (en) 1998-09-18 2010-05-25 University Of Washington Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue
US6319251B1 (en) 1998-09-24 2001-11-20 Hosheng Tu Medical device and methods for treating intravascular restenosis
US8257724B2 (en) 1998-09-24 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US6036689A (en) 1998-09-24 2000-03-14 Tu; Lily Chen Ablation device for treating atherosclerotic tissues
US20060240070A1 (en) 1998-09-24 2006-10-26 Cromack Keith R Delivery of highly lipophilic agents via medical devices
US6123718A (en) 1998-11-02 2000-09-26 Polymerex Medical Corp. Balloon catheter
US6701176B1 (en) 1998-11-04 2004-03-02 Johns Hopkins University School Of Medicine Magnetic-resonance-guided imaging, electrophysiology, and ablation
US6673290B1 (en) 1998-11-12 2004-01-06 Scimed Life Systems, Inc. Electrode structure for heating and ablating tissue and method for making and assembling the same
US7313444B2 (en) * 1998-11-20 2007-12-25 Pacesetter, Inc. Self-anchoring coronary sinus lead
US6607502B1 (en) 1998-11-25 2003-08-19 Atrionix, Inc. Apparatus and method incorporating an ultrasound transducer onto a delivery member
US6575933B1 (en) 1998-11-30 2003-06-10 Cryocath Technologies Inc. Mechanical support for an expandable membrane
EP1140278B1 (en) 1998-12-14 2004-05-19 Tre Esse Progettazione Biomedica S.r.l Catheter system for performing intramyocardiac therapeutic treatment
US20070066972A1 (en) 2001-11-29 2007-03-22 Medwaves, Inc. Ablation catheter apparatus with one or more electrodes
US6077227A (en) 1998-12-28 2000-06-20 Medtronic, Inc. Method for manufacture and implant of an implantable blood vessel cuff
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
US6102908A (en) 1999-01-04 2000-08-15 Tu; Lily Chen Rotatable apparatus having ablation capabilities
US7122019B1 (en) 2000-11-28 2006-10-17 Flowmedica Inc. Intra-aortic renal drug delivery catheter
US7329236B2 (en) 1999-01-11 2008-02-12 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US7481803B2 (en) 2000-11-28 2009-01-27 Flowmedica, Inc. Intra-aortic renal drug delivery catheter
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US6695830B2 (en) 1999-01-15 2004-02-24 Scimed Life Systems, Inc. Method for delivering medication into an arterial wall for prevention of restenosis
US6592526B1 (en) 1999-01-25 2003-07-15 Jay Alan Lenker Resolution ultrasound devices for imaging and treatment of body lumens
JP2002536040A (ja) 1999-02-02 2002-10-29 トランサージカル，インコーポレイテッド 体内高強度収束超音波アプリケータ
WO2000047118A1 (en) 1999-02-10 2000-08-17 Swaminathan Jayaraman Balloon catheter for cryotherapy and method of using same
US6427089B1 (en) 1999-02-19 2002-07-30 Edward W. Knowlton Stomach treatment apparatus and method
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6508774B1 (en) 1999-03-09 2003-01-21 Transurgical, Inc. Hifu applications with feedback control
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
ATE298536T1 (de) * 1999-03-09 2005-07-15 Thermage Inc Vorichtung zur behandlung von gewebe
US6492762B1 (en) * 1999-03-22 2002-12-10 Transurgical, Inc. Ultrasonic transducer, transducer array, and fabrication method
US6678558B1 (en) 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6409723B1 (en) 1999-04-02 2002-06-25 Stuart D. Edwards Treating body tissue by applying energy and substances
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US6366808B1 (en) 2000-03-13 2002-04-02 Edward A. Schroeppel Implantable device and method for the electrical treatment of cancer
US6738663B2 (en) 1999-04-09 2004-05-18 Oncostim, A Minnesota Corporation Implantable device and method for the electrical treatment of cancer
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6317615B1 (en) 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6939346B2 (en) * 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
US6923784B2 (en) 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6341236B1 (en) 1999-04-30 2002-01-22 Ivan Osorio Vagal nerve stimulation techniques for treatment of epileptic seizures
AU4696100A (en) * 1999-05-04 2000-11-17 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6178352B1 (en) 1999-05-07 2001-01-23 Woodside Biomedical, Inc. Method of blood pressure moderation
US6648854B1 (en) 1999-05-14 2003-11-18 Scimed Life Systems, Inc. Single lumen balloon-tipped micro catheter with reinforced shaft
WO2000069376A1 (en) 1999-05-18 2000-11-23 Silhouette Medical Inc. Surgical weight control device
US6692490B1 (en) * 1999-05-18 2004-02-17 Novasys Medical, Inc. Treatment of urinary incontinence and other disorders by application of energy and drugs
DE29909082U1 (de) 1999-05-25 1999-07-22 Starck Stimulations-, Sensing- und/oder Defibrillationselektrode sowie Ballon-Katheter zum Einbringen der Elektrode
US6442424B1 (en) 1999-05-26 2002-08-27 Impulse Dynamics N.V. Local cardiac motion control using applied electrical signals
US6304777B1 (en) 1999-05-26 2001-10-16 Impulse Dynamics N.V. Induction of cardioplegia applied electrical signals
US6375668B1 (en) 1999-06-02 2002-04-23 Hanson S. Gifford Devices and methods for treating vascular malformations
US7171263B2 (en) * 1999-06-04 2007-01-30 Impulse Dynamics Nv Drug delivery device
US6398792B1 (en) 1999-06-21 2002-06-04 O'connor Lawrence Angioplasty catheter with transducer using balloon for focusing of ultrasonic energy and method for use
JP2003503119A (ja) * 1999-06-25 2003-01-28 エモリ ユニバーシティ 迷走神経刺激用機器及び方法
US7426409B2 (en) 1999-06-25 2008-09-16 Board Of Regents, The University Of Texas System Method and apparatus for detecting vulnerable atherosclerotic plaque
US6272383B1 (en) 1999-06-28 2001-08-07 Woodside Biomedical, Inc. Electro-acupuncture method using an electrical stimulator
US6238392B1 (en) 1999-06-29 2001-05-29 Ethicon Endo-Surgery, Inc. Bipolar electrosurgical instrument including a plurality of balloon electrodes
US20020082515A1 (en) 1999-07-01 2002-06-27 Campbell Thomas H. Thermography catheter
US6179859B1 (en) 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6927049B2 (en) 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
US7053063B2 (en) 1999-07-21 2006-05-30 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes in tissue
US6300108B1 (en) 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US7175644B2 (en) 2001-02-14 2007-02-13 Broncus Technologies, Inc. Devices and methods for maintaining collateral channels in tissue
US6692494B1 (en) 1999-08-05 2004-02-17 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US7288096B2 (en) 2003-01-17 2007-10-30 Origin Medsystems, Inc. Apparatus for placement of cardiac defibrillator and pacer
US6450942B1 (en) 1999-08-20 2002-09-17 Cardiorest International Ltd. Method for reducing heart loads in mammals
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
AU7362400A (en) 1999-09-10 2001-04-10 Transurgical, Inc. Occlusion of tubular anatomical structures by energy application
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
WO2001022897A1 (en) 1999-09-28 2001-04-05 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
US6485489B2 (en) 1999-10-02 2002-11-26 Quantum Cor, Inc. Catheter system for repairing a mitral valve annulus
US6473644B1 (en) 1999-10-13 2002-10-29 Cyberonics, Inc. Method to enhance cardiac capillary growth in heart failure patients
US6287304B1 (en) 1999-10-15 2001-09-11 Neothermia Corporation Interstitial cauterization of tissue volumes with electrosurgically deployed electrodes
US6669655B1 (en) 1999-10-20 2003-12-30 Transurgical, Inc. Sonic element and catheter incorporating same
CA2389363A1 (en) 1999-10-29 2001-05-10 Universitat Zurich Method of volumetric blood flow measurement
CA2388861C (en) * 1999-11-16 2013-09-03 Robert A. Ganz System and method of treating abnormal tissue in the human esophagus
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6711444B2 (en) 1999-11-22 2004-03-23 Scimed Life Systems, Inc. Methods of deploying helical diagnostic and therapeutic element supporting structures within the body
EP1106206B1 (de) 1999-11-30 2007-06-27 BIOTRONIK GmbH & Co. KG Gerät zur Regelung der Herzfrequenz und der Herzpumpkraft
EP1106202A3 (de) 1999-11-30 2004-03-31 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Elektrode zu intravaskuläran Stimulation, Kardioversion und/oder Defibrillation
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US6415183B1 (en) 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US7494485B2 (en) 1999-12-10 2009-02-24 Sprite Solutions Fluidic interventional device and method of distal protection
US6800075B2 (en) 1999-12-10 2004-10-05 Sprite Solutions Method to inject and extract fluid at a treatment site to remove debris
US20030150464A1 (en) 1999-12-17 2003-08-14 Casscells S. Ward Inducing apoptosis of atrial myocytes to treat atrial fibrillation
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6623453B1 (en) 2000-01-19 2003-09-23 Vanny Corporation Chemo-thermo applicator for cancer treatment
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6356786B1 (en) 2000-01-20 2002-03-12 Electrocore Techniques, Llc Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain
US20060085046A1 (en) 2000-01-20 2006-04-20 Ali Rezai Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system
US6356787B1 (en) 2000-02-24 2002-03-12 Electro Core Techniques, Llc Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain
US6438423B1 (en) 2000-01-20 2002-08-20 Electrocore Technique, Llc Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain
US7184827B1 (en) * 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
WO2001055212A2 (en) 2000-01-27 2001-08-02 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
US6514226B1 (en) 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
US6663622B1 (en) 2000-02-11 2003-12-16 Iotek, Inc. Surgical devices and methods for use in tissue ablation procedures
US7565206B2 (en) 2000-02-17 2009-07-21 Standen Ltd. Treating a tumor or the like with electric fields at different orientations
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US6536949B1 (en) 2000-03-07 2003-03-25 Richard R. Heuser Catheter for thermal evaluation of arteriosclerotic plaque
US6770070B1 (en) 2000-03-17 2004-08-03 Rita Medical Systems, Inc. Lung treatment apparatus and method
US6458098B1 (en) 2000-03-17 2002-10-01 Nozomu Kanesaka Vascular therapy device
CA2399570C (en) 2000-03-24 2009-02-10 Transurgical, Inc. Apparatus and method for intrabody thermal treatment
US20010031981A1 (en) 2000-03-31 2001-10-18 Evans Michael A. Method and device for locating guidewire and treating chronic total occlusions
US6287608B1 (en) 2000-04-11 2001-09-11 Intellicardia, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator
US20020107514A1 (en) 2000-04-27 2002-08-08 Hooven Michael D. Transmural ablation device with parallel jaws
US20010044596A1 (en) 2000-05-10 2001-11-22 Ali Jaafar Apparatus and method for treatment of vascular restenosis by electroporation
WO2001087172A1 (en) 2000-05-12 2001-11-22 Cardima, Inc. Multi-channel rf energy delivery with coagulum reduction
US7006858B2 (en) 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
US7181261B2 (en) 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
DE60134739D1 (de) 2000-05-16 2008-08-21 Atrionix Inc Katheter mit lenkbarer spitze und spurausrichtungsmechanismus eines führungsdrahts
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
ATE290827T1 (de) 2000-06-13 2005-04-15 Atrionix Inc Chirurgische ablationssonde zum formen einer ringförmigen läsion
US7837720B2 (en) 2000-06-20 2010-11-23 Boston Scientific Corporation Apparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US6958075B2 (en) 2001-09-18 2005-10-25 Celsion Corporation Device and method for treatment of tissue adjacent a bodily conduit by thermocompression
US6477426B1 (en) 2000-06-20 2002-11-05 Celsion Corporation System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumors
US6511478B1 (en) 2000-06-30 2003-01-28 Scimed Life Systems, Inc. Medical probe with reduced number of temperature sensor wires
WO2002003872A2 (en) 2000-07-11 2002-01-17 Johns Hopkins University Application of photochemotherapy for the treatment of cardiac arrhythmias
CN1241658C (zh) * 2000-07-13 2006-02-15 普罗里森姆股份有限公司 一种在存活对象的体内施加能量的装置
AU7346801A (en) * 2000-07-13 2002-01-30 Transurgical Inc Energy application with inflatable annular lens
US6669691B1 (en) * 2000-07-18 2003-12-30 Scimed Life Systems, Inc. Epicardial myocardial revascularization and denervation methods and apparatus
DE60017205T2 (de) 2000-07-26 2006-01-12 Advanced Bionics Corp., Sylmar Wiederaufladbare vorrichtung zur stimulation des rückenmarks
US6699241B2 (en) 2000-08-11 2004-03-02 Northeastern University Wide-aperture catheter-based microwave cardiac ablation antenna
US6497711B1 (en) 2000-08-16 2002-12-24 Scimed Life Systems, Inc. Therectomy device having a light weight drive shaft and an imaging device
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6892099B2 (en) 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6955174B2 (en) 2000-08-18 2005-10-18 Uryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US6602246B1 (en) 2000-08-18 2003-08-05 Cryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
EP1311188A1 (en) 2000-08-24 2003-05-21 Volcano Therapeutics, Inc. Thermography catheter with flexible circuit temperature sensors
US6862479B1 (en) 2000-08-30 2005-03-01 Advanced Bionics Corporation Spinal cord stimulation as a therapy for sexual dysfunction
AU2434501A (en) 2000-09-07 2002-03-22 Sherwood Serv Ag Apparatus for and treatment of the intervertebral disc
US6511496B1 (en) 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US6405079B1 (en) 2000-09-22 2002-06-11 Mehdi M. Ansarinia Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US7623926B2 (en) 2000-09-27 2009-11-24 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6985774B2 (en) 2000-09-27 2006-01-10 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7616997B2 (en) 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US7158832B2 (en) 2000-09-27 2007-01-02 Cvrx, Inc. Electrode designs and methods of use for cardiovascular reflex control devices
US7499742B2 (en) 2001-09-26 2009-03-03 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US6470219B1 (en) 2000-10-02 2002-10-22 Novasys Medical, Inc. Apparatus and method for treating female urinary incontinence
US7306591B2 (en) * 2000-10-02 2007-12-11 Novasys Medical, Inc. Apparatus and methods for treating female urinary incontinence
US6640120B1 (en) * 2000-10-05 2003-10-28 Scimed Life Systems, Inc. Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US7104987B2 (en) * 2000-10-17 2006-09-12 Asthmatx, Inc. Control system and process for application of energy to airway walls and other mediums
US8417334B2 (en) 2000-10-26 2013-04-09 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions
US20030004549A1 (en) 2000-10-26 2003-01-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US6673066B2 (en) 2000-11-10 2004-01-06 Cardiostream, Inc. Apparatus and method to diagnose and treat vulnerable plaque
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US6942692B2 (en) 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
EP1335677B1 (en) 2000-11-16 2007-11-14 BARRX Medical, Inc. System of treating abnormal tissue in the human esophagus
US6728563B2 (en) * 2000-11-29 2004-04-27 St. Jude Medical, Daig Division, Inc. Electrophysiology/ablation catheter having “halo” configuration
US7081114B2 (en) 2000-11-29 2006-07-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Electrophysiology/ablation catheter having lariat configuration of variable radius
US6681136B2 (en) 2000-12-04 2004-01-20 Science Medicus, Inc. Device and method to modulate blood pressure by electrical waveforms
US6676657B2 (en) 2000-12-07 2004-01-13 The United States Of America As Represented By The Department Of Health And Human Services Endoluminal radiofrequency cauterization system
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US20020087151A1 (en) * 2000-12-29 2002-07-04 Afx, Inc. Tissue ablation apparatus with a sliding ablation instrument and method
US6666845B2 (en) 2001-01-04 2003-12-23 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
WO2002053207A2 (en) 2001-01-04 2002-07-11 Advanced Neuromodulation Systems, Inc. Implantable infusion pump
US6544223B1 (en) 2001-01-05 2003-04-08 Advanced Cardiovascular Systems, Inc. Balloon catheter for delivering therapeutic agents
WO2002054941A2 (en) * 2001-01-11 2002-07-18 Rita Medical Systems Inc Bone-treatment instrument and method
AU2002239929A1 (en) 2001-01-16 2002-07-30 Novacept Apparatus and method for treating venous reflux
WO2002056799A2 (en) 2001-01-19 2002-07-25 Boston Scientific Limited Introducer for deployment of branched prosthesis
US6600954B2 (en) 2001-01-25 2003-07-29 Biocontrol Medical Bcm Ltd. Method and apparatus for selective control of nerve fibers
US6740040B1 (en) * 2001-01-30 2004-05-25 Advanced Cardiovascular Systems, Inc. Ultrasound energy driven intraventricular catheter to treat ischemia
US6672312B2 (en) * 2001-01-31 2004-01-06 Transurgical, Inc. Pulmonary vein ablation with myocardial tissue locating
US20020107536A1 (en) 2001-02-07 2002-08-08 Hussein Hany M. Device and method for preventing kidney failure
US6681773B2 (en) 2001-02-28 2004-01-27 Chase Medical, Inc. Kit and method for use during ventricular restoration
US6564096B2 (en) 2001-02-28 2003-05-13 Robert A. Mest Method and system for treatment of tachycardia and fibrillation
AU2002250250A1 (en) 2001-03-01 2002-09-19 Three Arch Partners Intravascular device for treatment of hypertension
US6620151B2 (en) 2001-03-01 2003-09-16 Advanced Neuromodulation Systems, Inc. Non-constant pressure infusion pump
WO2002069821A1 (en) 2001-03-06 2002-09-12 Thermemed Corp. Vaporous delivery of thermal energy to tissue sites
US6786904B2 (en) 2002-01-10 2004-09-07 Triton Biosystems, Inc. Method and device to treat vulnerable plaque
WO2002085920A2 (en) 2001-03-08 2002-10-31 Oralbekov, Bakytzhan Alkane and alkane group dehydrogenation with organometallic catalysts
EP1379197A4 (en) 2001-03-23 2009-06-03 Durect Corp DISPOSAL OF MEDICINAL PRODUCTS OF DELAYED RELEASE DEVICES IMPLANTED IN MYOKARD TISSUE OR PER ICARDROOM
US20020147480A1 (en) 2001-04-04 2002-10-10 Mamayek Donald S. Treatment of lipid pool
US6764501B2 (en) 2001-04-10 2004-07-20 Robert A. Ganz Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US6666858B2 (en) 2001-04-12 2003-12-23 Scimed Life Systems, Inc. Cryo balloon for atrial ablation
CA2450376A1 (en) 2001-04-20 2002-10-31 The Board Of Regents Of The University Of Oklahoma Cardiac neuromodulation and methods of using same
WO2002085192A2 (en) 2001-04-23 2002-10-31 Transurgical, Inc. Improvements in ablation therapy
US6684105B2 (en) 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US6645223B2 (en) 2001-04-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Deployment and recovery control systems for embolic protection devices
US6972016B2 (en) * 2001-05-01 2005-12-06 Cardima, Inc. Helically shaped electrophysiology catheter
US20030130713A1 (en) 2001-05-21 2003-07-10 Stewart Mark T. Trans-septal catheter with retention mechanism
US6771996B2 (en) 2001-05-24 2004-08-03 Cardiac Pacemakers, Inc. Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
CA2447643A1 (en) 2001-05-29 2002-12-05 Medtronic, Inc. Closed-loop neuromodulation for prevention and treatment of cardiac conditions
US7127284B2 (en) 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US20030018327A1 (en) 2001-07-20 2003-01-23 Csaba Truckai Systems and techniques for lung volume reduction
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US20050010263A1 (en) 2001-07-27 2005-01-13 Patrick Schauerte Neurostimulation unit for immobilizing the heart during cardiosurgical operations
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US6786900B2 (en) 2001-08-13 2004-09-07 Cryovascular Systems, Inc. Cryotherapy methods for treating vessel dissections and side branch occlusion
US6600956B2 (en) 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US6622041B2 (en) 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US20030050635A1 (en) 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
WO2003020915A2 (en) 2001-08-31 2003-03-13 Cyto Pulse Sciences, Inc. Non-linear amplitude dielectrophoresis waveform for cell fusion
US7252679B2 (en) 2001-09-13 2007-08-07 Cordis Corporation Stent with angulated struts
US6761716B2 (en) * 2001-09-18 2004-07-13 Cardiac Pacemakers, Inc. System and method for assessing electrode-tissue contact and lesion quality during RF ablation by measurement of conduction time
US20060155261A1 (en) * 2001-09-19 2006-07-13 Curon Medical, Inc. Systems and methods for treating tissue regions of the body
JP3607231B2 (ja) 2001-09-28 2005-01-05 有限会社日本エレクテル 高周波加温バルーンカテーテル
WO2003028802A2 (en) 2001-10-01 2003-04-10 Am Discovery, Incorporated Devices for treating atrial fibrilation
JP2003111848A (ja) 2001-10-05 2003-04-15 Nihon Medix 加熱式バルーンカテーテル装置およびその加熱方法
US8974446B2 (en) 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US6671533B2 (en) * 2001-10-11 2003-12-30 Irvine Biomedical Inc. System and method for mapping and ablating body tissue of the interior region of the heart
US6926716B2 (en) 2001-11-09 2005-08-09 Surgrx Inc. Electrosurgical instrument
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
US6920883B2 (en) * 2001-11-08 2005-07-26 Arthrocare Corporation Methods and apparatus for skin treatment
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
WO2007136946A2 (en) 2001-12-03 2007-11-29 Xtent, Inc. Delivery catheter having active engagement mechanism for prosthesis
US20050149069A1 (en) 2001-12-04 2005-07-07 Bertolero Arthur A. Left atrial appendage devices and methods
US6746465B2 (en) * 2001-12-14 2004-06-08 The Regents Of The University Of California Catheter based balloon for therapy modification and positioning of tissue
US6748255B2 (en) 2001-12-14 2004-06-08 Biosense Webster, Inc. Basket catheter with multiple location sensors
US6972024B1 (en) 2001-12-21 2005-12-06 Advanced Cardiovascular Systems, Inc. Method of treating vulnerable plaque
US20030125790A1 (en) * 2001-12-27 2003-07-03 Vitaly Fastovsky Deployment device, system and method for medical implantation
US7326237B2 (en) 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
US20060189941A1 (en) 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
US7155284B1 (en) 2002-01-24 2006-12-26 Advanced Bionics Corporation Treatment of hypertension
US6814733B2 (en) 2002-01-31 2004-11-09 Biosense, Inc. Radio frequency pulmonary vein isolation
WO2003066155A2 (en) 2002-02-01 2003-08-14 The Cleveland Clinic Foundation Methods of affecting hypothalamic-related conditions
JP2005516697A (ja) 2002-02-01 2005-06-09 ザ クリーブランド クリニック ファウンデイション 独立的に移動可能な伝達構造を備えた神経刺激伝達デバイス
WO2003063692A2 (en) 2002-02-01 2003-08-07 The Cleveland Clinic Foundation Delivery device for stimulating the sympathetic nerve chain
US6949121B1 (en) 2002-02-07 2005-09-27 Sentient Engineering & Technology, Llc Apparatus and methods for conduits and materials
CN1646066A (zh) 2002-02-15 2005-07-27 效思因公司 利用热压缩和药物治疗邻近身体导管的组织的方法和装置
US7236821B2 (en) 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US6824516B2 (en) 2002-03-11 2004-11-30 Medsci Technologies, Inc. System for examining, mapping, diagnosing, and treating diseases of the prostate
WO2003076008A1 (en) 2002-03-14 2003-09-18 Brainsgate Ltd. Technique for blood pressure regulation
ITBS20020039U1 (it) 2002-03-20 2003-09-22 Fogazzi Di Venturelli Andrea & Catetere con elettrodo flessibile raffreddato
US6736835B2 (en) 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
AU2003220474A1 (en) 2002-03-21 2003-10-08 Radiant Medical, Inc. Measuring blood flow rate or cardiac output
AU2003220574A1 (en) 2002-03-27 2003-10-13 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US6979420B2 (en) 2002-03-28 2005-12-27 Scimed Life Systems, Inc. Method of molding balloon catheters employing microwave energy
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20070135875A1 (en) * 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8131371B2 (en) * 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8774913B2 (en) * 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US8150520B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US8145317B2 (en) * 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US8150519B2 (en) * 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7162303B2 (en) * 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US6685733B1 (en) 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
AU2003223583A1 (en) 2002-04-11 2003-10-27 Transvascular, Inc. Devices and methods for transluminal or transthoracic interstitial electrode placement
WO2003089046A1 (en) 2002-04-16 2003-10-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US20030199747A1 (en) 2002-04-19 2003-10-23 Michlitsch Kenneth J. Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030199767A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US6989009B2 (en) 2002-04-19 2006-01-24 Scimed Life Systems, Inc. Cryo balloon
US20030236443A1 (en) 2002-04-19 2003-12-25 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
JP4207451B2 (ja) * 2002-04-19 2009-01-14 パナソニック株式会社 円筒型リチウムイオン二次電池およびその製造方法
DE10217559B4 (de) 2002-04-19 2004-02-19 Universitätsklinikum Freiburg Vorrichtung zur minimalinvasiven, intravasalen Aortenklappenextraktion
US20030199768A1 (en) 2002-04-19 2003-10-23 Cespedes Eduardo Ignacio Methods and apparatus for the identification and stabilization of vulnerable plaque
US20030204161A1 (en) 2002-04-25 2003-10-30 Bozidar Ferek-Petric Implantable electroporation therapy device and method for using same
AUPS226402A0 (en) * 2002-05-13 2002-06-13 Advanced Metal Coatings Pty Limited An ablation catheter
US7294143B2 (en) * 2002-05-16 2007-11-13 Medtronic, Inc. Device and method for ablation of cardiac tissue
US7367974B2 (en) * 2004-09-20 2008-05-06 Wisconsin Alumni Research Foundation Electrode array for tissue ablation
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
US7153315B2 (en) 2002-06-11 2006-12-26 Boston Scientific Scimed, Inc. Catheter balloon with ultrasonic microscalpel blades
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
US6773447B2 (en) 2002-07-02 2004-08-10 Sentient Engineering & Technology, Llc Balloon catheter and treatment apparatus
GB2390545B (en) 2002-07-09 2005-04-20 Barts & London Nhs Trust Hollow organ probe
US6866662B2 (en) 2002-07-23 2005-03-15 Biosense Webster, Inc. Ablation catheter having stabilizing array
US8920826B2 (en) 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
TWI235073B (en) 2002-08-20 2005-07-01 Toray Industries Catheter for treating cardiac arrhythmias
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US6929639B2 (en) 2002-08-30 2005-08-16 Scimed Life Systems, Inc. Cryo ablation coil
US20040193228A1 (en) 2003-03-31 2004-09-30 Gerber Martin T. Method, system and device for treating various disorders of the pelvic floor by electrical stimulation of the left and right pudendal nerves
JP2004124257A (ja) * 2002-09-11 2004-04-22 Sumitomo Metal Mining Co Ltd 金属銅微粒子及びその製造方法
US6780183B2 (en) * 2002-09-16 2004-08-24 Biosense Webster, Inc. Ablation catheter having shape-changing balloon
US7150741B2 (en) 2002-09-20 2006-12-19 Advanced Neuromodulation Systems, Inc. Programmable dose control module
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc METHOD AND APPARATUS FOR ADMINISTERING INTRA-AORTIC SUBSTANCE TO A BRANCHED VESSEL
WO2004034767A2 (en) 2002-09-20 2004-04-29 Flowmedica, Inc. Catheter system for renal therapy
WO2004107965A2 (en) 2002-09-20 2004-12-16 Flowmedica, Inc. Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
AU2003276903A1 (en) 2002-09-20 2004-05-04 Flowmedica, Inc. Method and apparatus for selective material delivery via an intra-renal catheter
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
WO2004026371A2 (en) 2002-09-20 2004-04-01 Flowmedica, Inc. Method and apparatus for selective drug infusion via an intraaortic flow diverter delivery catheter
US7599737B2 (en) 2002-10-04 2009-10-06 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
ATE458534T1 (de) 2002-10-04 2010-03-15 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
US7306593B2 (en) * 2002-10-21 2007-12-11 Biosense, Inc. Prediction and assessment of ablation of cardiac tissue
US20040082947A1 (en) * 2002-10-25 2004-04-29 The Regents Of The University Of Michigan Ablation catheters
DE10257146A1 (de) 2002-12-06 2004-06-24 Admedes Schuessler Gmbh Metallelektrode
DE10252325B4 (de) 2002-11-11 2012-10-25 Admedes Schuessler Gmbh Sonde zur Hochfrequenz-Thermoablation sowie Verfahren zu deren Herstellung
US7404824B1 (en) 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US20040106952A1 (en) 2002-12-03 2004-06-03 Lafontaine Daniel M. Treating arrhythmias by altering properties of tissue
US20040162590A1 (en) 2002-12-19 2004-08-19 Whitehurst Todd K. Fully implantable miniature neurostimulator for intercostal nerve stimulation as a therapy for angina pectoris
WO2004062470A2 (en) 2003-01-03 2004-07-29 Advanced Neuromodulation Systems, Inc. System and method for stimulation of a person’s brain stem
US6847848B2 (en) 2003-01-07 2005-01-25 Mmtc, Inc Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
WO2004062525A2 (en) 2003-01-16 2004-07-29 Galil Medical Ltd. Device, system, and method for detecting and localizing obstruction within a blood vessel
JP4067976B2 (ja) 2003-01-24 2008-03-26 有限会社日本エレクテル 高周波加温バルーンカテーテル
KR20050098277A (ko) 2003-01-29 2005-10-11 이-필 파마 리미티드 위장관 내 약물의 능동 송달
US7167750B2 (en) 2003-02-03 2007-01-23 Enteromedics, Inc. Obesity treatment with electrically induced vagal down regulation
US7223266B2 (en) 2003-02-04 2007-05-29 Cardiodex Ltd. Methods and apparatus for hemostasis following arterial catheterization
WO2004073505A2 (en) * 2003-02-20 2004-09-02 Prorhythm, Inc. Cardiac ablation devices
US9603545B2 (en) 2003-02-21 2017-03-28 3Dt Holdings, Llc Devices, systems, and methods for removing targeted lesions from vessels
US8465452B2 (en) 2003-02-21 2013-06-18 3Dt Holdings, Llc Devices, systems, and methods for removing stenotic lesions from vessels
US7818053B2 (en) 2003-02-21 2010-10-19 Dtherapeutics, Llc Devices, systems and methods for plaque type determination
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
US20040163655A1 (en) 2003-02-24 2004-08-26 Plc Systems Inc. Method and catheter system applicable to acute renal failure
US7004911B1 (en) 2003-02-24 2006-02-28 Hosheng Tu Optical thermal mapping for detecting vulnerable plaque
US20040167506A1 (en) 2003-02-25 2004-08-26 Scimed Life Systems, Inc. Medical devices employing ferromagnetic heating
WO2004078066A2 (en) * 2003-03-03 2004-09-16 Sinus Rhythm Technologies, Inc. Primary examiner
US20040176699A1 (en) 2003-03-03 2004-09-09 Volcano Therapeutics, Inc. Thermography catheter with improved wall contact
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7597704B2 (en) 2003-04-28 2009-10-06 Atritech, Inc. Left atrial appendage occlusion device with active expansion
US20040243022A1 (en) 2003-04-29 2004-12-02 Medtronic Vascular, Inc. Method and system of detecting vulnerable plaque by sensing motion of thin fibrous cap
US7517342B2 (en) 2003-04-29 2009-04-14 Boston Scientific Scimed, Inc. Polymer coated device for electrically medicated drug delivery
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
JP2004337400A (ja) 2003-05-16 2004-12-02 Terumo Corp 薬剤投与キット
WO2004105807A2 (en) 2003-05-27 2004-12-09 Venture Manufacturing, Llc Balloon centered radially expanding ablation device
AU2004251673B2 (en) 2003-06-04 2010-01-28 Synecor Llc Intravascular electrophysiological system and methods
JP2006526464A (ja) 2003-06-05 2006-11-24 フローメディカ，インコーポレイテッド 分枝した身体管腔において両側介入または診断を行うためのシステムおよび方法
US7738952B2 (en) 2003-06-09 2010-06-15 Palo Alto Investors Treatment of conditions through modulation of the autonomic nervous system
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
WO2004110258A2 (en) 2003-06-10 2004-12-23 Cardiofocus, Inc. Guided cardiac ablation catheters
US20080208169A1 (en) 2003-06-11 2008-08-28 Boyle Edward M Jr Body-Space Treatment Catheter
US20060167437A1 (en) 2003-06-17 2006-07-27 Flowmedica, Inc. Method and apparatus for intra aortic substance delivery to a branch vessel
US7066895B2 (en) 2003-06-30 2006-06-27 Ethicon, Inc. Ultrasonic radial focused transducer for pulmonary vein ablation
US20060269531A1 (en) 2003-07-18 2006-11-30 Eastern Virginia Medical School Apparatus for generating electrical pulses and methods of using the same
EP1659970A4 (en) 2003-08-05 2008-05-21 Flowmedica Inc SYSTEM AND METHOD FOR PREVENTING RADIO CONTRAST-INDUCED NEPHROPATHY
US7742809B2 (en) 2003-08-25 2010-06-22 Medtronic, Inc. Electroporation catheter with sensing capabilities
AU2004285412A1 (en) * 2003-09-12 2005-05-12 Minnow Medical, Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US7569052B2 (en) 2003-09-12 2009-08-04 Boston Scientific Scimed, Inc. Ablation catheter with tissue protecting assembly
US7736362B2 (en) 2003-09-15 2010-06-15 Boston Scientific Scimed, Inc. Catheter balloons
US7502650B2 (en) 2003-09-22 2009-03-10 Cvrx, Inc. Baroreceptor activation for epilepsy control
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US20050153885A1 (en) 2003-10-08 2005-07-14 Yun Anthony J. Treatment of conditions through modulation of the autonomic nervous system
US7186209B2 (en) 2003-10-09 2007-03-06 Jacobson Jerry I Cardioelectromagnetic treatment
US7416549B2 (en) * 2003-10-10 2008-08-26 Boston Scientific Scimed, Inc. Multi-zone bipolar ablation probe assembly
WO2005037070A2 (en) 2003-10-11 2005-04-28 The Regents Of The University Of California Method and system for nerve repair, nanoknife, mems platform and uses thereof
US7480532B2 (en) 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
CA2536168A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
EP1682196A2 (en) 2003-11-10 2006-07-26 Angiotech International Ag Medical implants and anti-scarring agents
US7367970B2 (en) 2003-11-11 2008-05-06 Biosense Webster Inc. Externally applied RF for pulmonary vein isolation
CA2547021A1 (en) 2003-11-25 2005-06-09 F.D. Cardio Ltd. Stent positioning using inflation tube
JP4391221B2 (ja) 2003-12-22 2009-12-24 有限会社日本エレクテル 高周波加温バルーンカテーテル
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US20080015659A1 (en) 2003-12-24 2008-01-17 Yi Zhang Neurostimulation systems and methods for cardiac conditions
US8396560B2 (en) 2004-11-18 2013-03-12 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
JP5138229B2 (ja) 2003-12-24 2013-02-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 不可逆的電気穿孔による組織アブレーション
WO2005065559A1 (ja) 2004-01-06 2005-07-21 Toray Industries, Inc. バルーンカテーテル
US7150745B2 (en) 2004-01-09 2006-12-19 Barrx Medical, Inc. Devices and methods for treatment of luminal tissue
US7371231B2 (en) 2004-02-02 2008-05-13 Boston Scientific Scimed, Inc. System and method for performing ablation using a balloon
US20050182479A1 (en) 2004-02-13 2005-08-18 Craig Bonsignore Connector members for stents
US7499747B2 (en) 2004-03-02 2009-03-03 Cvrx, Inc. External baroreflex activation
US7198632B2 (en) 2004-03-02 2007-04-03 Boston Scientific Scimed, Inc. Occlusion balloon catheter with longitudinally expandable balloon
WO2005091910A2 (en) 2004-03-04 2005-10-06 Flowmedica, Inc. Sheath for use in peripheral interventions
US20050209548A1 (en) 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
US20050228415A1 (en) 2004-03-23 2005-10-13 Michael Gertner Methods and devices for percutaneous, non-laparoscopic treatment of obesity
US20070233170A1 (en) 2004-03-23 2007-10-04 Michael Gertner Extragastric Balloon
US7841978B2 (en) 2004-03-23 2010-11-30 Michael Gertner Methods and devices for to treatment of obesity
US8001976B2 (en) 2004-03-23 2011-08-23 Michael Gertner Management systems for the surgically treated obese patient
US8343031B2 (en) 2004-03-23 2013-01-01 Michael Gertner Obesity treatment systems
US20080071306A1 (en) 2004-03-23 2008-03-20 Michael Gertner Extragastric Balloon With Attachment Tabs
US20080147002A1 (en) 2004-03-23 2008-06-19 Michael Eric Gertner Obesity treatment systems
US20060195139A1 (en) 2004-03-23 2006-08-31 Michael Gertner Extragastric devices and methods for gastroplasty
WO2006049725A2 (en) 2004-03-23 2006-05-11 Minimus Surgical Systems Surgical systems and devices to enhance gastric restriction therapies
US7946976B2 (en) 2004-03-23 2011-05-24 Michael Gertner Methods and devices for the surgical creation of satiety and biofeedback pathways
US20060142790A1 (en) 2004-03-23 2006-06-29 Michael Gertner Methods and devices to facilitate connections between body lumens
US20080300618A1 (en) 2004-03-23 2008-12-04 Michael Eric Gertner Obesity treatment systems
US7255675B2 (en) 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US7854733B2 (en) 2004-03-24 2010-12-21 Biosense Webster, Inc. Phased-array for tissue treatment
US7323006B2 (en) 2004-03-30 2008-01-29 Xtent, Inc. Rapid exchange interventional devices and methods
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US7654997B2 (en) * 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US7566319B2 (en) 2004-04-21 2009-07-28 Boston Scientific Scimed, Inc. Traction balloon
CA2563817C (en) 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
EP1750799A2 (en) 2004-05-04 2007-02-14 The Cleveland Clinic Foundation Methods of treating medical conditions by neuromodulation of the sympathetic nervous system
US20050251116A1 (en) 2004-05-05 2005-11-10 Minnow Medical, Llc Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter
US8412348B2 (en) 2004-05-06 2013-04-02 Boston Scientific Neuromodulation Corporation Intravascular self-anchoring integrated tubular electrode body
EP1750506A4 (en) 2004-05-14 2010-03-17 Flowmedica Inc BILATERAL LOCAL RENAL DELIVERY FOR THE TREATMENT OF CONGESTIVE HEART FAILURE AND BNP THERAPY
US20050261672A1 (en) 2004-05-18 2005-11-24 Mark Deem Systems and methods for selective denervation of heart dysrhythmias
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
EP1750607A2 (en) 2004-06-02 2007-02-14 Medtronic, Inc. Loop ablation apparatus and method
WO2005123183A2 (en) 2004-06-11 2005-12-29 University Of South Florida Electroporation device and method for delivery to ocular tissue
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7197354B2 (en) 2004-06-21 2007-03-27 Mediguide Ltd. System for determining the position and orientation of a catheter
US20060067972A1 (en) 2004-06-23 2006-03-30 Flowmedica, Inc. Devices for renal-based heart failure treatment
WO2006012050A2 (en) 2004-06-30 2006-02-02 Cvrx, Inc. Connection structures for extra-vascular electrode lead body
US20060004417A1 (en) 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
US7481808B2 (en) 2004-06-30 2009-01-27 Ethicon, Inc. Flexible electrode device and surgical apparatus equipped with same
FR2873385B1 (fr) 2004-07-23 2006-10-27 Centre Nat Rech Scient Cnrse Surveillance et controle d'une electroporation
US7373204B2 (en) 2004-08-19 2008-05-13 Lifestim, Inc. Implantable device and method for treatment of hypertension
EP1796568A1 (en) 2004-09-09 2007-06-20 Vnus Medical Technologies, Inc. Methods and apparatus for treatment of hollow anatomical structures
EP1804907A2 (en) 2004-09-10 2007-07-11 The Cleveland Clinic Foundation Methods and systems of achieving hemodynamic control through neuromodulation
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US7742795B2 (en) 2005-03-28 2010-06-22 Minnow Medical, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US9713730B2 (en) 2004-09-10 2017-07-25 Boston Scientific Scimed, Inc. Apparatus and method for treatment of in-stent restenosis
US8545488B2 (en) 2004-09-17 2013-10-01 The Spectranetics Corporation Cardiovascular imaging system
US20060069323A1 (en) 2004-09-24 2006-03-30 Flowmedica, Inc. Systems and methods for bi-lateral guidewire cannulation of branched body lumens
US7635383B2 (en) 2004-09-28 2009-12-22 Boston Scientific Scimed, Inc. Rotating stent delivery system for side branch access and protection and method of using same
US20060069385A1 (en) 2004-09-28 2006-03-30 Scimed Life Systems, Inc. Methods and apparatus for tissue cryotherapy
US20060074453A1 (en) 2004-10-04 2006-04-06 Cvrx, Inc. Baroreflex activation and cardiac resychronization for heart failure treatment
WO2006044738A2 (en) 2004-10-18 2006-04-27 Maroon Biotech Corporation Methods and compositions for treatment of free radical injury
US7524318B2 (en) * 2004-10-28 2009-04-28 Boston Scientific Scimed, Inc. Ablation probe with flared electrodes
US7753907B2 (en) 2004-10-29 2010-07-13 Boston Scientific Scimed, Inc. Medical device systems and methods
US7937143B2 (en) 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US20070083239A1 (en) * 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US7200445B1 (en) 2005-10-21 2007-04-03 Asthmatx, Inc. Energy delivery devices and methods
WO2006052940A2 (en) 2004-11-05 2006-05-18 Asthmatx, Inc. Medical device with procedure improvement features
US20060100618A1 (en) * 2004-11-08 2006-05-11 Cardima, Inc. System and method for performing ablation and other medical procedures using an electrode array with flex circuit
US8332047B2 (en) 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US20060116720A1 (en) 2004-12-01 2006-06-01 Penny Knoblich Method and apparatus for improving renal function
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
EP1835964B1 (en) 2004-12-21 2016-03-09 EBR Systems, Inc. Leadless cardiac system for pacing and arrhythmia treatment
US20080009927A1 (en) 2005-01-11 2008-01-10 Vilims Bradley D Combination Electrical Stimulating and Infusion Medical Device and Method
US9833618B2 (en) 2005-02-04 2017-12-05 Palo Alto Investors Methods and compositions for treating a disease condition in a subject
US20060182873A1 (en) 2005-02-17 2006-08-17 Klisch Leo M Medical devices
US7548780B2 (en) 2005-02-22 2009-06-16 Cardiac Pacemakers, Inc. Cell therapy and neural stimulation for cardiac repair
US8801701B2 (en) 2005-03-09 2014-08-12 Sunnybrook Health Sciences Centre Method and apparatus for obtaining quantitative temperature measurements in prostate and other tissue undergoing thermal therapy treatment
US7674256B2 (en) 2005-03-17 2010-03-09 Boston Scientific Scimed, Inc. Treating internal body tissue
EP2327429B1 (en) 2005-03-23 2014-09-17 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US20060224153A1 (en) 2005-04-05 2006-10-05 Fischell Robert E Catheter system for the treatment of atrial fibrillation
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US20060247760A1 (en) 2005-04-29 2006-11-02 Medtronic Vascular, Inc. Methods and apparatus for treatment of aneurysms adjacent branch arteries
CA2611963A1 (en) 2005-05-10 2007-06-14 Michael Gertner Obesity treatment systems
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US7419486B2 (en) * 2005-06-15 2008-09-02 St. Jude Medical, Atrial Fibrillation Division, Inc. Treatment and diagnostic catheters with hydrogel electrodes
US7850685B2 (en) * 2005-06-20 2010-12-14 Medtronic Ablation Frontiers Llc Ablation catheter
ES2670822T3 (es) 2005-06-29 2018-06-01 Zoll Circulation, Inc. Dispositivos y sistemas para el enfriamiento endovascular rápido
AU2006266149B2 (en) 2005-06-30 2012-04-12 Rox Medical, Inc. Devices, systems, and methods for creation of a peripherally located fistula
EP1909679B1 (en) 2005-07-11 2013-11-20 Medtronic Ablation Frontiers LLC Low power tissue ablation system
WO2007014063A2 (en) 2005-07-21 2007-02-01 Vnus Medical Technologies, Inc. Systems and methods for treating a hollow anatomical structure
US20070021803A1 (en) 2005-07-22 2007-01-25 The Foundry Inc. Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
CA2616760C (en) 2005-07-26 2014-10-07 Rox Medical, Inc. Devices, systems, and methods for peripheral arteriovenous fistula creation
US7591996B2 (en) 2005-08-17 2009-09-22 University Of Washington Ultrasound target vessel occlusion using microbubbles
US7582111B2 (en) 2005-08-22 2009-09-01 Incept, Llc Steep-taper flared stents and apparatus and methods for delivering them
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
JP2009507617A (ja) 2005-09-14 2009-02-26 ネオガイド システムズ， インコーポレイテッド 経腔的及び他の操作を行うための方法及び装置
US20070093804A1 (en) 2005-10-17 2007-04-26 Coaptus Medical Corporation Control systems for patient devices, including devices for securing cardiovascular tissue, and associated methods
DE102005050344A1 (de) 2005-10-20 2007-05-03 Siemens Ag Kryokatheter zur Einführung in ein Körpergefäß sowie medizinische Untersuchungs- und Behandlungsvorrichtung
US8226637B2 (en) 2005-11-01 2012-07-24 Japan Electel, Inc. Balloon catheter system
US7747324B2 (en) 2005-11-10 2010-06-29 Electrocore Llc Electrical stimulation treatment of bronchial constriction
US7959627B2 (en) * 2005-11-23 2011-06-14 Barrx Medical, Inc. Precision ablating device
US20070156200A1 (en) 2005-12-29 2007-07-05 Lilian Kornet System and method for regulating blood pressure and electrolyte balance
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
EP1988941A2 (en) 2006-01-31 2008-11-12 Nanocopoeia, Inc. Nanoparticle coating of surfaces
US20070179496A1 (en) 2006-01-31 2007-08-02 Medtronic, Inc. Flexible catheter for ablation therapy
US8571650B2 (en) 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US20070208256A1 (en) 2006-03-03 2007-09-06 Medtronic Vascular, Inc. Multiple Branch Tubular Prosthesis and Methods
US8585753B2 (en) 2006-03-04 2013-11-19 John James Scanlon Fibrillated biodegradable prosthesis
US20070219576A1 (en) 2006-03-16 2007-09-20 Medtronic Vascular, Inc. Reversibly and Radially Expandable Electroactive Polymer Element for Temporary Occlusion of a Vessel
WO2007109171A2 (en) 2006-03-17 2007-09-27 Microcube, Llc Devices and methods for creating continuous lesions
US20070225781A1 (en) 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
EP2010085A1 (en) 2006-03-31 2009-01-07 Breval S.R.L. Device and method for the thermal ablation of tumors by means of high-frequency electromagnetic energy under overpressure conditions
US20080004673A1 (en) 2006-04-03 2008-01-03 Cvrx, Inc. Implantable extravascular electrostimulation system having a resilient cuff
CA2649119A1 (en) 2006-04-13 2007-12-13 Mirabilis Medica, Inc. Methods and apparatus for the treatment of menometrorrhagia, endometrial pathology, and cervical neoplasia using high intensity focused ultrasound energy
US8401650B2 (en) 2008-04-10 2013-03-19 Electrocore Llc Methods and apparatus for electrical treatment using balloon and electrode
US8019435B2 (en) 2006-05-02 2011-09-13 Boston Scientific Scimed, Inc. Control of arterial smooth muscle tone
EP2032045A2 (en) 2006-05-24 2009-03-11 Emcision Limited Vessel sealing device and methods
US20070282376A1 (en) 2006-06-06 2007-12-06 Shuros Allan C Method and apparatus for neural stimulation via the lymphatic system
US7647101B2 (en) 2006-06-09 2010-01-12 Cardiac Pacemakers, Inc. Physical conditioning system, device and method
US20070287994A1 (en) 2006-06-12 2007-12-13 Pankaj Amrit Patel Endoscopically Introducible Expandable Bipolar Probe
WO2007146215A2 (en) 2006-06-12 2007-12-21 Pankaj Patel Endoscopically introducible expandable cautery device
US20080097251A1 (en) 2006-06-15 2008-04-24 Eilaz Babaev Method and apparatus for treating vascular obstructions
EP2092957B2 (en) 2006-06-28 2019-11-20 Medtronic Ardian Luxembourg S.à.r.l. Systems for thermally-induced renal neuromodulation
US8409172B2 (en) 2006-08-03 2013-04-02 Hansen Medical, Inc. Systems and methods for performing minimally invasive procedures
US20080039904A1 (en) 2006-08-08 2008-02-14 Cherik Bulkes Intravascular implant system
WO2008031077A2 (en) 2006-09-08 2008-03-13 Hansen Medical, Inc. Robotic surgical system with forward-oriented field of view guide instrument navigation
US8617149B2 (en) 2006-10-02 2013-12-31 Boston Scientific Scimed, Inc. Common bond, double-balloon catheter
US8641660B2 (en) 2006-10-04 2014-02-04 P Tech, Llc Methods and devices for controlling biologic microenvironments
US20080091255A1 (en) 2006-10-11 2008-04-17 Cardiac Pacemakers Implantable neurostimulator for modulating cardiovascular function
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
JP5479901B2 (ja) 2006-10-18 2014-04-23 べシックス・バスキュラー・インコーポレイテッド 身体組織に対する所望の温度作用の誘発
CA2666661C (en) 2006-10-18 2015-01-20 Minnow Medical, Inc. Tuned rf energy and electrical tissue characterization for selective treatment of target tissues
EP2455034B1 (en) 2006-10-18 2017-07-19 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US7615072B2 (en) 2006-11-14 2009-11-10 Medtronic Vascular, Inc. Endoluminal prosthesis
US20080255550A1 (en) 2006-11-30 2008-10-16 Minos Medical Systems and methods for less invasive neutralization by ablation of tissue including the appendix and gall bladder
US20080140002A1 (en) 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
KR20090121292A (ko) 2007-02-22 2009-11-25 라모트 앳 텔-아비브 유니버시티 리미티드 취약한 플레이크 또는 동맥류와 같은 약해진 혈관벽의 치료
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
US9259233B2 (en) 2007-04-06 2016-02-16 Hologic, Inc. Method and device for distending a gynecological cavity
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US11395694B2 (en) * 2009-05-07 2022-07-26 St. Jude Medical, Llc Irrigated ablation catheter with multiple segmented ablation electrodes
US20090270850A1 (en) 2007-06-20 2009-10-29 Tea Time Partners, L.P., Organized In Texas Devices and methods for the ablation of tissue in the lateral direction
US8630704B2 (en) 2007-06-25 2014-01-14 Cardiac Pacemakers, Inc. Neural stimulation with respiratory rhythm management
US8251992B2 (en) 2007-07-06 2012-08-28 Tyco Healthcare Group Lp Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
US20090018486A1 (en) 2007-07-13 2009-01-15 Menachem Goren Diagnosis and treatment of vericocele and prostate disorders
WO2009036468A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc Transurethral systems and methods for ablation treatment of prostate tissue
US9283034B2 (en) 2007-09-26 2016-03-15 Retrovascular, Inc. Recanalization system using radiofrequency energy
US8235986B2 (en) 2007-10-05 2012-08-07 Coaptus Medical Corporation Systems and methods for transeptal cardiac procedures, including tissue penetrating members and associated methods
WO2009055286A1 (en) 2007-10-24 2009-04-30 Edwards Lifesciences Corporation Percutaneous nitinol stent extraction device
WO2009065078A1 (en) 2007-11-14 2009-05-22 Pathway Medical Technologies, Inc. Delivery and administration of compositions using interventional catheters
US20090143640A1 (en) 2007-11-26 2009-06-04 Voyage Medical, Inc. Combination imaging and treatment assemblies
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8021413B2 (en) 2007-12-27 2011-09-20 Cook Medical Technologies Llc Low profile medical device
US9204927B2 (en) * 2009-05-13 2015-12-08 St. Jude Medical, Atrial Fibrillation Division, Inc. System and method for presenting information representative of lesion formation in tissue during an ablation procedure
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US8469919B2 (en) 2008-02-19 2013-06-25 Boston Scientific Scimed, Inc. Apparatus and methods for uniformly distributing coolant within a cryo-ablation device
WO2009113064A2 (en) 2008-03-11 2009-09-17 Hayim Lindenbaum A diagnostic medical device for endoscopic use
US20090247933A1 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
EP2529686B1 (en) 2008-05-09 2015-10-14 Holaira, Inc. System for treating a bronchial tree
US8480663B2 (en) 2008-05-15 2013-07-09 Boston Scientific Scimed, Inc. Apparatus and methods for cryogenically ablating tissue and adjusting cryogenic ablation regions
US8128617B2 (en) 2008-05-27 2012-03-06 Boston Scientific Scimed, Inc. Electrical mapping and cryo ablating with a balloon catheter
US8187261B2 (en) 2008-05-29 2012-05-29 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
JP2010021134A (ja) 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd リチウム複合金属酸化物の製造方法
JP5636363B2 (ja) 2008-06-13 2014-12-03 ディージェイティー、 エルエルシー 衝撃波バルーンカテーテル装置
US20090318749A1 (en) 2008-06-19 2009-12-24 Craig Stolen Method and apparatus for pacing and intermittent ischemia
US10736689B2 (en) 2008-08-20 2020-08-11 Prostacare Pty Ltd Low-corrosion electrode for treating tissue
US20100069837A1 (en) 2008-09-16 2010-03-18 Boston Scientific Scimed, Inc. Balloon Assembly and Method for Therapeutic Agent Delivery
JP5622729B2 (ja) 2008-09-22 2014-11-12 べシックス・バスキュラー・インコーポレイテッド 身体組織に対して温度効果を誘発するシステム
DE102008048616B4 (de) 2008-09-23 2010-08-05 Olympus Winter & Ibe Gmbh Urologischer Ballonkatheter
EP2349440B1 (en) 2008-10-07 2019-08-21 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US11376061B2 (en) 2008-11-11 2022-07-05 Covidien Lp Energy delivery device and methods of use
US10987494B2 (en) 2008-11-11 2021-04-27 Covidien Lp Pleated or folded catheter-mounted balloon
WO2013154775A1 (en) 2012-04-10 2013-10-17 Covidien Lp Energy delivery device and methods of manufacturing
CN104068933B (zh) 2008-11-11 2017-03-15 施菲姆德控股有限责任公司 小外形的电极组件
US20150105659A1 (en) 2008-11-11 2015-04-16 Covidien Lp Energy delivery device and methods of use
US9468364B2 (en) 2008-11-14 2016-10-18 Intuitive Surgical Operations, Inc. Intravascular catheter with hood and image processing systems
CN102271603A (zh) 2008-11-17 2011-12-07 明诺医学股份有限公司 得知或未得知组织形态的选择性能量积累
WO2010082993A2 (en) 2008-12-11 2010-07-22 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
WO2010070766A1 (ja) 2008-12-19 2010-06-24 有限会社日本エレクテル バルーンカテーテルシステム
US20100160906A1 (en) 2008-12-23 2010-06-24 Asthmatx, Inc. Expandable energy delivery devices having flexible conductive elements and associated systems and methods
US9352174B2 (en) 2008-12-30 2016-05-31 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation system with blood leakage minimization and tissue protective capabilities
US20100168739A1 (en) 2008-12-31 2010-07-01 Ardian, Inc. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8808345B2 (en) 2008-12-31 2014-08-19 Medtronic Ardian Luxembourg S.A.R.L. Handle assemblies for intravascular treatment devices and associated systems and methods
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
EP2208506A1 (en) 2009-01-16 2010-07-21 Oncotherm Kft. Intraluminar oncothermia catheter
US20100191232A1 (en) 2009-01-27 2010-07-29 Boveda Marco Medical Llc Catheters and methods for performing electrophysiological interventions
US20100217250A1 (en) 2009-02-24 2010-08-26 Sierra Surgical Technologies Methods and systems for controlled thermal tissue
EP2404171A4 (en) 2009-03-03 2016-01-27 Mc10 Inc SYSTEMS, METHODS AND DEVICES HAVING INTEGRATED INTEGRATED CIRCUIT ELEMENTS FOR DETECTING AND ADMINISTERING THERAPY
US20100249702A1 (en) 2009-03-24 2010-09-30 Abbott Cardiovascular Systems Inc. Porous catheter balloon and method of making same
US8287532B2 (en) 2009-04-13 2012-10-16 Biosense Webster, Inc. Epicardial mapping and ablation catheter
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
JP5444840B2 (ja) 2009-05-21 2014-03-19 東レ株式会社 バルーン付きアブレーションカテーテル及びバルーン付きアブレーションカテーテルシステム
WO2011005901A2 (en) 2009-07-09 2011-01-13 Silhouette Medical Inc. Apparatus for treating medical conditions of hollow anatomical structures
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
EP2496165B1 (en) 2009-11-04 2017-01-11 Emcision Limited Lumenal remodelling device
US20110112400A1 (en) 2009-11-06 2011-05-12 Ardian, Inc. High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation
CA2780608C (en) 2009-11-11 2019-02-26 Innovative Pulmonary Solutions, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
AU2010319333B2 (en) * 2009-11-13 2014-02-20 St. Jude Medical, Inc. Assembly of staggered ablation elements
US20110137155A1 (en) 2009-12-09 2011-06-09 Boston Scientific Scimed, Inc. Delivery device for localized delivery of a therapeutic agent
US20110263921A1 (en) 2009-12-31 2011-10-27 Anthony Vrba Patterned Denervation Therapy for Innervated Renal Vasculature
US20110270238A1 (en) 2009-12-31 2011-11-03 Raed Rizq Compliant Cryoballoon Apparatus for Denervating Ostia of the Renal Arteries
EP2525715A4 (en) 2010-01-19 2014-06-04 Medtronic Ardian Luxembourg S R L METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY
WO2011119857A2 (en) 2010-03-24 2011-09-29 Shifamed, Llc Intravascular tissue disruption
WO2011130534A2 (en) 2010-04-14 2011-10-20 Boston Scientific Scimed, Inc. Renal artery denervation apparatus employing helical shaping arrangement
US8870863B2 (en) 2010-04-26 2014-10-28 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
JP5792802B2 (ja) 2010-05-12 2015-10-14 シファメド・ホールディングス・エルエルシー 低い外形の電極組立体
US9358020B2 (en) 2010-06-25 2016-06-07 Boston Scientific Scimed Inc. Catheter device for delivery energy to a vein
US20120029505A1 (en) 2010-07-30 2012-02-02 Jenson Mark L Self-Leveling Electrode Sets for Renal Nerve Ablation
US9084609B2 (en) 2010-07-30 2015-07-21 Boston Scientific Scime, Inc. Spiral balloon catheter for renal nerve ablation
US9155589B2 (en) * 2010-07-30 2015-10-13 Boston Scientific Scimed, Inc. Sequential activation RF electrode set for renal nerve ablation
US9463062B2 (en) 2010-07-30 2016-10-11 Boston Scientific Scimed, Inc. Cooled conductive balloon RF catheter for renal nerve ablation
US20120029496A1 (en) 2010-07-30 2012-02-02 Scott Smith Renal nerve ablation using mild freezing and microwave energy
US20120029512A1 (en) 2010-07-30 2012-02-02 Willard Martin R Balloon with surface electrodes and integral cooling for renal nerve ablation
US20120089134A1 (en) 2010-10-11 2012-04-12 Christopher Horvath Contactless Photodisruptive Laser assisted Cataract Surgery
US20120109021A1 (en) 2010-10-27 2012-05-03 Roger Hastings Renal denervation catheter employing acoustic wave generator arrangement
EP2645955B1 (en) 2010-12-01 2016-10-26 Boston Scientific Scimed, Inc. Expandable angular vascular electrode for renal nerve ablation
US20120157992A1 (en) * 2010-12-15 2012-06-21 Scott Smith Off-wall electrode device for renal nerve ablation
US20120157993A1 (en) * 2010-12-15 2012-06-21 Jenson Mark L Bipolar Off-Wall Electrode Device for Renal Nerve Ablation
CN203354638U (zh) 2010-12-21 2013-12-25 泰尔茂株式会社 气囊导管及通电系统
US20120184952A1 (en) * 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
US20120191079A1 (en) 2011-01-20 2012-07-26 Hansen Medical, Inc. System and method for endoluminal and translumenal therapy
WO2012122157A1 (en) 2011-03-07 2012-09-13 Tidal Wave Technology, Inc. Radiofrequency ablation catheter device
US20140012251A1 (en) 2011-03-07 2014-01-09 Tidal Wave Technology, Inc. Ablation devices and methods
EP2677953A4 (en) 2011-03-31 2014-10-08 Tidal Wave Technology Inc RADIO FREQUENCY ABLATION CATHETER DEVICE
WO2012130337A1 (en) 2011-04-01 2012-10-04 Flux Medical N.V. System, device and method for ablation of a vessel's wall from the inside
US20120259269A1 (en) 2011-04-08 2012-10-11 Tyco Healthcare Group Lp Iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery
US9237925B2 (en) 2011-04-22 2016-01-19 Ablative Solutions, Inc. Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
EP2701795B1 (en) 2011-04-28 2020-12-09 Interventional Autonomics Corporation Neuromodulation systems for treating acute heart failure syndromes
US8909316B2 (en) * 2011-05-18 2014-12-09 St. Jude Medical, Cardiology Division, Inc. Apparatus and method of assessing transvascular denervation
US20120296232A1 (en) * 2011-05-18 2012-11-22 St. Jude Medical, Inc. Method and apparatus of assessing transvascular denervation
EP2709517B1 (en) 2011-05-18 2017-01-11 St. Jude Medical, Inc. Apparatus for assessing transvascular denervation
EP2706938A4 (en) 2011-06-15 2014-11-26 Tidal Wave Technology Inc CATHETER DEVICE FOR ABLATION BY HIGH FREQUENCY
WO2013009977A1 (en) 2011-07-12 2013-01-17 David Lambert Device for reducing renal sympathetic nerve activity
CN103987334A (zh) 2011-07-12 2014-08-13 沃夫医药公司 经由肾盂的肾神经去神经支配
AU2012283908B2 (en) 2011-07-20 2017-02-16 Boston Scientific Scimed, Inc. Percutaneous devices and methods to visualize, target and ablate nerves
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US20130053732A1 (en) 2011-08-24 2013-02-28 Richard R. Heuser Devices and methods for treating hypertension with energy
JP6188159B2 (ja) 2011-08-26 2017-08-30 サイマップ ホールディング リミテッド 動脈壁を支配する機能的神経を位置決し、識別するためのシステムおよび方法ならびにそのカテーテル
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
CN103987336A (zh) 2011-09-14 2014-08-13 波士顿科学西美德公司 具有多种消融模式的消融装置
US9603659B2 (en) 2011-09-14 2017-03-28 Boston Scientific Scimed Inc. Ablation device with ionically conductive balloon
CN106823131B (zh) 2011-09-30 2019-12-20 柯惠有限合伙公司 能量传递装置以及使用方法
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
JP6522942B2 (ja) 2011-10-04 2019-05-29 べシックス・バスキュラー・インコーポレイテッド ステント内再狭窄を治療するためのシステム及び方法
US20130090578A1 (en) 2011-10-10 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US9079000B2 (en) 2011-10-18 2015-07-14 Boston Scientific Scimed, Inc. Integrated crossing balloon catheter
EP2775948B1 (en) 2011-11-08 2018-04-04 Boston Scientific Scimed, Inc. Ostial renal nerve ablation
EP2779929A1 (en) 2011-11-15 2014-09-24 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation monitoring
US20140350553A1 (en) 2011-11-21 2014-11-27 Denerve Inc. Renal artery ablation catheter and system
CN202386778U (zh) 2011-11-29 2012-08-22 北京天助畅运医疗技术股份有限公司 射频消融装置
SG11201402610QA (en) 2011-12-09 2014-10-30 Metavention Inc Therapeutic neuromodulation of the hepatic system
WO2013096913A2 (en) 2011-12-23 2013-06-27 Vessix Vascular, Inc. Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US20130172877A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Balloon expandable multi-electrode rf ablation catheter
WO2013101452A1 (en) 2011-12-28 2013-07-04 Boston Scientific Scimed, Inc. Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
EP3915629A1 (en) 2012-01-26 2021-12-01 Autonomix Medical, Inc. Controlled sympathectomy and micro-ablation systems and methods
US20130231659A1 (en) 2012-03-01 2013-09-05 Boston Scientific Scimed, Inc. Off-wall and contact electrode devices and methods for nerve modulation
US20130231658A1 (en) 2012-03-01 2013-09-05 Boston Scientific Scimed, Inc. Expandable ablation device and methods for nerve modulation
US20130253628A1 (en) 2012-03-22 2013-09-26 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
EP3135237B1 (en) 2012-04-13 2019-07-24 Covidien LP Energy delivery device
US10660703B2 (en) 2012-05-08 2020-05-26 Boston Scientific Scimed, Inc. Renal nerve modulation devices
US9642673B2 (en) 2012-06-27 2017-05-09 Shockwave Medical, Inc. Shock wave balloon catheter with multiple shock wave sources
WO2014012053A1 (en) 2012-07-13 2014-01-16 Boston Scientific Scimed, Inc. Off -wall electrode devices for nerve modulation
US20140018888A1 (en) 2012-07-16 2014-01-16 Boston Scientific Scimed, Inc. Flow controlled radiofrequency medical balloon
CA2878588A1 (en) 2012-07-30 2014-02-06 Northwestern University Radiofrequency probe for circumferential ablation of a hollow cavity
US9237984B2 (en) 2012-08-10 2016-01-19 Shockwave Medical, Inc. Shockwave nerve therapy system and method
US9987086B2 (en) 2012-08-22 2018-06-05 Boston Scientific Scimed, Inc. Multiple electrode RF ablation catheter and method
US10321946B2 (en) 2012-08-24 2019-06-18 Boston Scientific Scimed, Inc. Renal nerve modulation devices with weeping RF ablation balloons
US20140067029A1 (en) 2012-08-28 2014-03-06 Boston Scientific Scimed, Inc. Renal nerve modulation and ablation catheter electrode design
WO2014056460A1 (zh) 2012-08-29 2014-04-17 第三军医大学第一附属医院 肾脏去交感神经多功能消融导管系统
JP2014054430A (ja) 2012-09-13 2014-03-27 Nippon Koden Corp カテーテル
CN104768487A (zh) 2012-09-13 2015-07-08 波士顿科学西美德公司 肾脏神经调节球囊及其制造和使用方法
JP6074051B2 (ja) 2012-10-10 2017-02-01 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 血管内神経変調システム及び医療用デバイス
WO2014071223A1 (en) 2012-11-02 2014-05-08 Vessix Vascular, Inc. Flex circuit/balloon assemblies utilizing textured surfaces for enhanced bonding
US10286182B2 (en) 2012-11-12 2019-05-14 Boston Scientific Scimed, Inc. Renal catheter shaft design
US10272269B2 (en) 2012-11-13 2019-04-30 Silk Road Medical, Inc. Devices and methods for endoluminal delivery of either fluid or energy for denervation
US20140316496A1 (en) 2012-11-21 2014-10-23 NeuroTronik IP Holding (Jersey) Limited Intravascular Electrode Arrays for Neuromodulation
CN202960760U (zh) 2012-12-13 2013-06-05 乐普（北京）医疗器械股份有限公司 去肾交感神经术用多点射频消融电极
US10238875B2 (en) 2012-12-19 2019-03-26 Adi Mashiach Systems and methods for hypertension control
WO2014100226A1 (en) 2012-12-21 2014-06-26 Huennekens Scott Tissue ablation catheter and methods of ablating tissue
US20140188103A1 (en) 2012-12-31 2014-07-03 Volcano Corporation Methods and Apparatus for Neuromodulation Utilizing Optical-Acoustic Sensors
WO2014110579A1 (en) 2013-01-14 2014-07-17 Boston Scientific Scimed, Inc. Renal nerve ablation catheter
US10195467B2 (en) 2013-02-21 2019-02-05 Boston Scientific Scimed, Inc. Ablation catheter system with wireless radio frequency temperature sensor
US20140249524A1 (en) 2013-03-01 2014-09-04 Boston Scientific Scimed, Inc. System and method for performing renal nerve modulation
US20140303617A1 (en) 2013-03-05 2014-10-09 Neuro Ablation, Inc. Intravascular nerve ablation devices & methods
AU2014225622A1 (en) 2013-03-08 2015-09-17 Symple Surgical Inc. Balloon catheter apparatus with microwave emitter
US9956033B2 (en) 2013-03-11 2018-05-01 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
WO2014143571A1 (en) 2013-03-11 2014-09-18 Boston Scientific Scimed, Inc. Medical devices for modulating nerves
CN105188587A (zh) 2013-03-13 2015-12-23 波士顿科学医学有限公司 具有线性离子化传导性气球的可转向消融设备
US9861431B2 (en) 2013-03-13 2018-01-09 Kyphon SÀRL Radiofrequency inflatable device
US9028488B2 (en) 2013-03-14 2015-05-12 Kyphon Sarl Radio frequency catheter to target ligamentum flavum
US20140276756A1 (en) 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Wall-sparing renal nerve ablation catheter with spaced electrode structures
JP6220044B2 (ja) 2013-03-15 2017-10-25 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経アブレーションのための医療用デバイス
US9333113B2 (en) 2013-03-15 2016-05-10 Abbott Cardiovascular Systems Inc. System and method for denervation
EP2851027A1 (en) 2013-03-15 2015-03-25 Tidal Wave Technology, Inc. Ablation catheter devices and methods
CN105228546B (zh) 2013-03-15 2017-11-14 波士顿科学国际有限公司 利用阻抗补偿的用于治疗高血压的医疗器械和方法
US9173701B2 (en) 2013-03-15 2015-11-03 Warsaw Orthopedic, Inc. RF enabled inflatable bone tamp
US9179973B2 (en) 2013-03-15 2015-11-10 St. Jude Medical, Cardiology Division, Inc. Feedback systems and methods for renal denervation utilizing balloon catheter
WO2014179768A1 (en) 2013-05-02 2014-11-06 Harrington Douglas C Devices and methods for detection and treatment of the aorticorenal ganglion
US10390879B2 (en) 2013-05-20 2019-08-27 Mayo Foundation For Medical Education And Research Devices and methods for ablation of tissue
EP3003191A4 (en) 2013-06-05 2017-02-08 Metavention, Inc. Modulation of targeted nerve fibers
EP3010435A1 (en) 2013-06-21 2016-04-27 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US9943365B2 (en) 2013-06-21 2018-04-17 Boston Scientific Scimed, Inc. Renal denervation balloon catheter with ride along electrode support
US9707036B2 (en) 2013-06-25 2017-07-18 Boston Scientific Scimed, Inc. Devices and methods for nerve modulation using localized indifferent electrodes
US20150005799A1 (en) 2013-06-27 2015-01-01 Boston Scientific Scimed, Inc. Renal nerve modulation balloon having improved robustness
US9872728B2 (en) 2013-06-28 2018-01-23 St. Jude Medical, Cardiology Division, Inc. Apparatuses and methods for affixing electrodes to an intravascular balloon
WO2015002787A1 (en) 2013-07-01 2015-01-08 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
EP3019103A1 (en) 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Multiple electrode conductive balloon
EP3019106A1 (en) 2013-07-11 2016-05-18 Boston Scientific Scimed, Inc. Medical device with stretchable electrode assemblies
EP3049007B1 (en) 2013-07-19 2019-06-12 Boston Scientific Scimed, Inc. Spiral bipolar electrode renal denervation balloon
WO2015013205A1 (en) 2013-07-22 2015-01-29 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation
US10695124B2 (en) 2013-07-22 2020-06-30 Boston Scientific Scimed, Inc. Renal nerve ablation catheter having twist balloon
JP6159888B2 (ja) 2013-08-22 2017-07-05 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 腎神経変調バルーンへの接着性を向上させたフレキシブル回路
JP6263622B2 (ja) 2013-08-22 2018-01-17 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． パターン化された凹壁外形を有する医療用バルーン
US9895194B2 (en) 2013-09-04 2018-02-20 Boston Scientific Scimed, Inc. Radio frequency (RF) balloon catheter having flushing and cooling capability
CN105530885B (zh) 2013-09-13 2020-09-22 波士顿科学国际有限公司 具有气相沉积覆盖层的消融球囊
EP2848225A1 (en) 2013-09-13 2015-03-18 Covidien LP A pleated or folded catheter-mounted balloon
US11246654B2 (en) 2013-10-14 2022-02-15 Boston Scientific Scimed, Inc. Flexible renal nerve ablation devices and related methods of use and manufacture
EP3057520A1 (en) 2013-10-15 2016-08-24 Boston Scientific Scimed, Inc. Medical device balloon
JP6259099B2 (ja) 2013-10-18 2018-01-10 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 可撓性を備える導電性ワイヤを備えるバルーン・カテーテル、並びに関連する使用および製造方法
CN105658163B (zh) 2013-10-25 2020-08-18 波士顿科学国际有限公司 去神经柔性电路中的嵌入式热电偶
CN103549993B (zh) 2013-11-21 2016-01-13 廖申扬 射频消融肾动脉交感神经的导丝导管系统
US20150148794A1 (en) 2013-11-25 2015-05-28 Boston Scientific Scimed, Inc. Low profile medical devices for sympathetic nerve ablation
EP3091923A1 (en) 2014-01-06 2016-11-16 Boston Scientific Scimed, Inc. Sympathetic nerve ablation devices with an expansion-limiting member
WO2015103617A1 (en) 2014-01-06 2015-07-09 Boston Scientific Scimed, Inc. Tear resistant flex circuit assembly
JP2017501843A (ja) 2014-01-10 2017-01-19 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． フレキシブル回路アセンブリを有する医療装置
US9848949B2 (en) 2014-01-21 2017-12-26 Oscor Inc. Renal denervation system
EP3102136B1 (en) 2014-02-04 2018-06-27 Boston Scientific Scimed, Inc. Alternative placement of thermal sensors on bipolar electrode
US10543039B2 (en) 2014-03-18 2020-01-28 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use and manufacture
CN106413611A (zh) 2014-04-17 2017-02-15 波士顿科学国际有限公司 用于治疗性热处理的医疗装置
EP3148467A1 (en) 2014-05-28 2017-04-05 Boston Scientific Scimed, Inc. Nerve modulation devices with cooling capabilities
CN106456247B (zh) 2014-06-20 2019-08-09 波士顿科学国际有限公司 具有印刷组件用于交感神经消融的医疗器械
JP2016086998A (ja) 2014-10-31 2016-05-23 テルモ株式会社 アブレーションカテーテル
US9795780B2 (en) 2014-12-18 2017-10-24 Abbott Cardiovascular Systems Inc. System for denervation

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10420606B2 (en) 2002-04-08 2019-09-24 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US9125666B2 (en) 2003-09-12 2015-09-08 Vessix Vascular, Inc. Selectable eccentric remodeling and/or ablation of atherosclerotic material
US9125667B2 (en) 2004-09-10 2015-09-08 Vessix Vascular, Inc. System for inducing desirable temperature effects on body tissue
US8920414B2 (en) 2004-09-10 2014-12-30 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8939970B2 (en) 2004-09-10 2015-01-27 Vessix Vascular, Inc. Tuned RF energy and electrical tissue characterization for selective treatment of target tissues
US8364237B2 (en) 2005-03-28 2013-01-29 Vessix Vascular, Inc. Tuned RF energy for selective treatment of atheroma and other target tissues and/or structures
US9486355B2 (en) 2005-05-03 2016-11-08 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US9974607B2 (en) 2006-10-18 2018-05-22 Vessix Vascular, Inc. Inducing desirable temperature effects on body tissue
US10413356B2 (en) 2006-10-18 2019-09-17 Boston Scientific Scimed, Inc. System for inducing desirable temperature effects on body tissue
US10213252B2 (en) 2006-10-18 2019-02-26 Vessix, Inc. Inducing desirable temperature effects on body tissue
US8496653B2 (en) 2007-04-23 2013-07-30 Boston Scientific Scimed, Inc. Thrombus removal
US9327100B2 (en) 2008-11-14 2016-05-03 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8396548B2 (en) 2008-11-14 2013-03-12 Vessix Vascular, Inc. Selective drug delivery in a lumen
US8401667B2 (en) 2008-11-17 2013-03-19 Vessix Vascular, Inc. Selective accumulation of energy with or without knowledge of tissue topography
US8551096B2 (en) 2009-05-13 2013-10-08 Boston Scientific Scimed, Inc. Directional delivery of energy and bioactives
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
KR101912960B1 (ko) 2010-10-25 2018-10-29 메드트로닉 아르디언 룩셈부르크 에스에이알엘 다중전극 어레이를 구비한 신장 신경조절용 카테터 장치 및 관련된 시스템 및 방법
CN102715949A (zh) * 2010-10-26 2012-10-10 美敦力阿迪安卢森堡有限责任公司 神经调节冷冻治疗设备和相关系统和方法
US10357302B2 (en) 2011-07-12 2019-07-23 Verve Medical, Inc. Renal nerve denervation via the renal pelvis
US10786295B2 (en) 2011-07-12 2020-09-29 Verve Medical, Inc. Renal nerve denervation via the renal pelvis
CN103957981A (zh) * 2011-08-24 2014-07-30 理查德·R·休瑟 利用能量治疗高血压的设备和方法
CN108095821A (zh) * 2011-11-08 2018-06-01 波士顿科学西美德公司 孔部肾神经消融
CN108095821B (zh) * 2011-11-08 2021-05-25 波士顿科学西美德公司 孔部肾神经消融
CN103908334A (zh) * 2012-12-31 2014-07-09 上海微创电生理医疗科技有限公司 多电极消融导管
CN105473090B (zh) * 2013-03-15 2019-05-03 波士顿科学国际有限公司 重建身体通道的组织或邻近身体通道的组织的方法及装置
CN105473090A (zh) * 2013-03-15 2016-04-06 波士顿科学国际有限公司 重建身体通道的组织或邻近身体通道的组织的方法及装置
CN105473091A (zh) * 2013-06-21 2016-04-06 波士顿科学国际有限公司 具有可一起移动的电极支撑件的肾脏去神经球囊导管
CN105473091B (zh) * 2013-06-21 2020-01-21 波士顿科学国际有限公司 具有可一起移动的电极支撑件的肾脏去神经球囊导管
CN105555348A (zh) * 2013-09-09 2016-05-04 美敦力阿迪安卢森堡有限公司 具有能量递送热电偶组件的神经调节导管装置和系统以及相关方法
CN105555348B (zh) * 2013-09-09 2019-03-01 美敦力Af卢森堡有限责任公司 具有能量递送热电偶组件的神经调节导管装置和系统以及相关方法
US11213678B2 (en) 2013-09-09 2022-01-04 Medtronic Ardian Luxembourg S.A.R.L. Method of manufacturing a medical device for neuromodulation
CN105578982A (zh) * 2013-09-30 2016-05-11 美敦力阿迪安卢森堡有限公司 具有螺旋轨道的血管内神经调节装置及相关方法
CN106852703A (zh) * 2015-12-08 2017-06-16 上海安通医疗科技有限公司 一种肾动脉射频消融导管

Also Published As

Publication number Publication date
US20100137860A1 (en) 2010-06-03
US20160000498A1 (en) 2016-01-07
EP2623061A2 (en) 2013-08-07
EP2623060A2 (en) 2013-08-07
EP2091455A4 (en) 2010-08-25
US8740896B2 (en) 2014-06-03
US10420606B2 (en) 2019-09-24
EP2623060A3 (en) 2013-11-20
EP2623062B1 (en) 2022-04-20
CN101583323B (zh) 2012-07-11
US8444640B2 (en) 2013-05-21
WO2008061152A3 (en) 2009-04-30
EP2623061A3 (en) 2013-11-20
CN102847230A (zh) 2013-01-02
EP2091455B1 (en) 2015-01-07
US20130012867A1 (en) 2013-01-10
CN102847230B (zh) 2015-07-01
US20160331448A1 (en) 2016-11-17
US20130296767A1 (en) 2013-11-07
ES2534611T3 (es) 2015-04-24
US20130304054A1 (en) 2013-11-14
ES2914103T3 (es) 2022-06-07
US8454594B2 (en) 2013-06-04
DE202007019648U1 (de) 2014-12-22
DE202007019669U1 (de) 2015-04-01
EP2623061B1 (en) 2016-05-04
DE202007019647U1 (de) 2014-12-23
JP2014100580A (ja) 2014-06-05
US20070129720A1 (en) 2007-06-07
JP5469460B2 (ja) 2014-04-16
ES2585215T3 (es) 2016-10-04
DE202007019645U1 (de) 2014-12-22
DE202007019646U1 (de) 2014-12-23
WO2008061152A2 (en) 2008-05-22
JP2010509032A (ja) 2010-03-25
EP2091455A2 (en) 2009-08-26
EP2623062A2 (en) 2013-08-07
US9757193B2 (en) 2017-09-12
US20130304064A1 (en) 2013-11-14
US9023037B2 (en) 2015-05-05
US8347891B2 (en) 2013-01-08
US8721637B2 (en) 2014-05-13
US9827041B2 (en) 2017-11-28
EP2623062A3 (en) 2013-11-20
US20180104005A1 (en) 2018-04-19

Similar Documents

Publication Publication Date Title
CN101583323B (zh) 用于对体腔进行非连续周缘治疗的装置
US8774913B2 (en) Methods and apparatus for intravasculary-induced neuromodulation
US7617005B2 (en) Methods and apparatus for thermally-induced renal neuromodulation
US20120143181A1 (en) Apparatuses for monopolar renal neuromodulation
WO2008070413A2 (en) Methods for treating heart arrhythmia
US20190374244A1 (en) System for nerve modulation and innocuous thermal gradient nerve block

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: MEDTRONIC AF LUXEMBOURG S.A R.L

Free format text: FORMER OWNER: ARDIAN INC.

Effective date: 20120405

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20120405

Address after: Luxemburg Luxemburg

Patentee after: Medtronic Ardian Luxembourg S.A.R.L

Address before: American California

Patentee before: Ardian Inc.

C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MEDTRONIC AF LUXEMBOURG S. A. R. L.

Free format text: FORMER NAME: MEDTRONIC ARDIAN AF LUXEMBOURG INC.

CP01 Change in the name or title of a patent holder

Address after: Luxemburg Luxemburg

Patentee after: Ardian Inc.

Address before: Luxemburg Luxemburg

Patentee before: Medtronic Ardian Luxembourg S.A.R.L