CN101584582B - Objective measurement method and system of human body current sensory threshold based on electrical brain analysis - Google Patents
Objective measurement method and system of human body current sensory threshold based on electrical brain analysis Download PDFInfo
- Publication number
- CN101584582B CN101584582B CN2009101000489A CN200910100048A CN101584582B CN 101584582 B CN101584582 B CN 101584582B CN 2009101000489 A CN2009101000489 A CN 2009101000489A CN 200910100048 A CN200910100048 A CN 200910100048A CN 101584582 B CN101584582 B CN 101584582B
- Authority
- CN
- China
- Prior art keywords
- experimenter
- eeg signals
- galvanism
- current
- constant current
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
This invention discloses objective measurement method and system of human body current sensory threshold based on electrical brain analysis, including steps as follows: (1) regarding electrical brain signals under condition with electrical stimulation evoked potential and under condition without stimulation as two types of signal templates, training and creating a mode identification algorithm; (2) applying current stimulations of different strengths to tested person, and recording electrical brain signals of the tested person; (3) performing mode identification to the electrical signals of the tested person recorded in the step (2) using the mode identification mode in the step (1), dividing electrical signals of the tested person into electrical brain signals under condition without stimulation and electrical brain signals under condition with electrical stimulation; (5) calculating current stimulation sensory threshold of the tested person using the result in the step (3). Accordingly, this invention is strong in objectivity, high in accuracy rate and excellent in efficiency.
Description
Technical field
The present invention relates to a kind of medical instrument, relate in particular to a kind of body current sensation threshold values objective measurement method and system based on brain electricity analytical.
Background technology
Human body impression to external world is by the sensor sensation, conducts to nerve centre system-brain via nerve fiber then and finishes.The difference sensation of human body skin, for example press, vibration, hot and cold, the pain sensation etc., respectively by the impression of different sensor and by the peripheral nerve fiber conduction of different-diameter, human body is mainly conducted by the refreshing C fiber of the most very thin no myelin the impression of heating signal, the refrigeration signal of experiencing is conducted by the neural A δ of the sheath fiber that has of minimum, and vibration signal is then conducted by the bigger neural A beta of sheath that has.Clinical experiment shows, 5Hz, 250Hz, the simple alternating current electricity irritation of 2000Hz cause neural impulsion respectively by the nerve conduction of three kinds of sizes: the most very thin nonmedullated nerve C fiber, less have the neural A δ of sheath peacekeeping bigger the neural A β dimension of sheath arranged.Because these neural corresponding respectively different sensory patterns, therefore, as stimulation, can estimate the degree that is quick of perception of this several modes of human body respectively in order to the simple sinusoidal alternating current of upper frequency.
BEP is the bioelectric that the central nervous system produces in experiencing the external world or intrinsic stimuli process, and somatosensory evoked potential can be used to judge that whether the body sense stimulates by the perception of brain institute.
Chinese patent application 03109874.6 discloses a kind of body current and has felt objective quantitative system and measuring method thereof, to measure the mode that adopts experimenter and operator's double blinding, by the electric stimulator of microcomputerized control with quantitative galvanism experimenter, the experimenter is according to acousto-optic hint, with own the subjective feeling that stimulates is imported by patient's control unit, microprocessor system in the measuring system is according to experimenter's input signal, filtering algorithm according to a kind of Physiological Psychology, whether decision draws experimenter's electric current sensation threshold values or gives the intensity that stimulates next time and stimulate next time, through repeatedly stimulating, after experimenter's respective process, body current feels that objective quantitative testing system calculates the neuroelectricity sensation threshold values that demonstrates the experimenter.
But body current feels that objective quantitative system and measuring method thereof need the experimenter that subjective judgment is made in stimulation in the prior art, and this just makes to measure and have very strong subjective consciousness that cause accuracy low, testing efficiency is not high.
Summary of the invention
The invention provides a kind of test result is accurate, efficient is high body current sensation threshold values objective measurement method and system based on brain electricity analytical.
A kind of body current sensation threshold values objective measurement method of analyzing based on brain electricity (EEG) may further comprise the steps:
(1) set up algorithm for pattern recognition:
Repeatedly give the electricity irritation that one of experimenter surpasses threshold current, synchronous recording experimenter EEG signals, and superposeing obtains the incident that electricity irritation causes and brings out current potential;
Do not having under the galvanism condition record experimenter EEG signals, and superposeing and obtain average EEG signals;
With the template of the average EEG signals under electric stimulus inducing current potential and the non-stimulated condition as two class signals, algorithm for pattern recognition is set up in training;
Training is set up the algorithm for pattern recognition detailed process and is (referring to Fig. 2), and EEG signals at first generates a time series X through the low pass filter of a 3Hz; Calculate X then respectively and Euclidean distance X1 and the X2 that stimulates brain electricity template and non-stimulated brain electricity template arranged, and form the segmental characteristic vector of this EEG signals by X1 and X2; To under the electricity irritation condition and do not have each brain electricity sheet under the galvanism condition all to calculate its characteristic vector, form the training feature vector collection, then according to the different mode recognizer that is adopted (as artificial neural network, support vector machine etc.) training mode recognizer, thus effective algorithm for pattern recognition set up.
Repeatedly give the experimenter one and surpass in the electricity irritation of threshold current, described threshold current is initial general definite by experience or this area general knowledge, about general 0.3～3mA.
(2) repeatedly give experimenter's varying strength galvanism, record experimenter's EEG signals.
Described varying strength electric current, current intensity are 0～10mA, give experimenter's varying strength galvanism number of times not strict restriction here, but are 5～30 times in order to improve the general number of times of certainty of measurement.Number of times is very few to be difficult to obtain suitable certainty of measurement, can cause feeling fatigue of experimenter in the time of too much, can't improve certainty of measurement.
(3) analyze EEG signals, judge whether the experimenter feels galvanism:
The algorithm for pattern recognition that obtains with step (1) carries out pattern recognition to experimenter's EEG signals of step (2) record, experimenter's EEG signals is divided into the EEG signals under the non-stimulated condition and EEG signals under the electricity irritation condition is arranged;
If recognition result is the EEG signals that belongs under the no electricity irritation condition, think that the experimenter does not feel galvanism;
If recognition result is to belong to the EEG signals that has under the electricity irritation condition, think that then subject perception has arrived galvanism.
(4) utilize the result of step (3) to calculate experimenter's galvanism sensation threshold values.
The galvanism sensation threshold values that calculates the experimenter is to adopt the method for limits, method of constant stimulus or its deriving method to calculate.
The described method of limits is about to stimulate the mode of pressing increasing or decreasing series, changes with the small step that equates at interval, seeks from a kind of instantaneous transfer point of another kind of reaction or position of threshold value of being reacted to;
Described method of constant stimulus is promptly set several particular stimulation values, and each stimulation presents repeatedly at random, causes that according to stimulus variable threshold value is tried to achieve in the distribution of the number of times that reacts in certain.
Can calculate experimenter's galvanism and feel threshold values according to the definition of sensation threshold values or with the current intensity minima and the peaked average of current intensity of imperceptible galvanism of the current intensity maximum of the current intensity minima of the galvanism felt or imperceptible galvanism or the galvanism felt concretely.
The current intensity minima of the described galvanism of feeling be obtain in the step (3) the minima in pairing each current intensity is arranged in the EEG signals under the electricity irritation condition.
The current intensity maximum of described imperceptible galvanism is in the EEG signals under the no electricity irritation condition that obtains in the step (3), the maximum in pairing each current intensity.
The present invention also provides a kind of body current sensation threshold values objective measurement system based on brain electricity analytical, comprising:
Date processing/control master unit: be used to control the constant current control circuit and send constant current and the EEG signals of memorizer is carried out analyzing and processing, obtain the experimenter and whether feel the judged result of galvanism;
Constant current control circuit: be used to send constant current;
Galvanism electrode: be used to conduct the constant current stimulation experimenter that the constant current control circuit sends;
Electrode for encephalograms: the EEG signals that is used to gather the experimenter;
Eeg amplifier: the EEG signals that is used for electrode for encephalograms is gathered is amplified;
Memorizer: be used to store EEG signals after being amplified by eeg amplifier, algorithm for pattern recognition and whether feel the result of galvanism by the experimenter that signal processing obtains;
Display: be used to show measurement process parameters and measurement result; Procedure parameter comprises galvanism size, galvanism wave mode, galvanism persistent period and stimulus intervals time etc., and measurement result is by signal processing and calculates resulting current perception threshold;
When measuring body current sensation threshold values, the galvanism electrode gives experimenter's varying strength galvanism, electrode for encephalograms is gathered experimenter's EEG signals, date processing/control master unit utilizes the algorithm for pattern recognition that prestores in the memorizer that experimenter's EEG signals is divided into the EEG signals under the non-stimulated condition with experimenter's EEG signals and EEG signals under the electricity irritation condition is arranged, and calculates experimenter's galvanism sensation threshold values again according to the ultimate value of the pairing current intensity of EEG signals under the different condition.
Human body electric current of the present invention sensation threshold values objective measurement method adopts single BEP detection technique to judge whether galvanism has caused BEP, and then judges whether the experimenter has felt and have the following advantages this stimulation:
(1) compares with conventional art, do not need the experimenter to make subjective judgment, more objective whether having felt to stimulate.
(2) owing to taked single BEP detection technique, compare the BEP detection compares with the average filter method, do not need to the experimenter repeatedly the brain electricity under the irriate condition carry out superposed average and handle, can whether feel that this stimulation makes a determination to the experimenter, can prevent subject perception fatigue effectively, improve measurement accuracy, can improve detection efficiency simultaneously.
Description of drawings
Fig. 1 is the body current sensation threshold values objective measurement instrument system structured flowchart based on brain electricity analytical of the present invention;
Fig. 2 judges the algorithm for pattern recognition flow chart signal that whether experimenter feels stimulates for of the present invention based on brain electricity (EEG);
When Fig. 3 measured experimenter's current perception threshold for adopting method of constant stimulus, stimulus intensity and subject perception were to the sketch map that stimulates number of times percentage ratio.
The specific embodiment
As shown in Figure 1, the present invention is based on the body current sensation threshold values objective measurement system of brain electricity analytical, comprising:
Constant current control circuit 3: be used to send constant current;
Galvanism electrode 4: be used to conduct the constant current stimulation experimenter that the constant current control circuit sends;
Electrode for encephalograms 5: the EEG signals that is used to gather the experimenter;
Eeg amplifier 6: the EEG signals that is used for electrode for encephalograms is gathered is amplified;
Memorizer 7: be used to store EEG signals, algorithm for pattern recognition and signal processing results by after the eeg amplifier amplification;
Date processing/control master unit 2: be used to control the constant current control circuit and send constant current and the EEG signals of memorizer is carried out analyzing and processing;
Display 8: be used to show measurement process parameters and measurement result.
When measuring body current sensation threshold values,
Repeatedly give the electricity irritation that 1 one of experimenters surpass threshold current, synchronous recording experimenter EEG signals, and superposeing obtains the incident that electricity irritation causes and brings out current potential;
There is not record experimenter 1 EEG signals under the galvanism condition;
With the training set of the EEG signals under electric stimulus inducing current potential and the non-stimulated condition as two class signals, algorithm for pattern recognition is set up in training;
After setting up algorithm for pattern recognition, adopt the method for limits to measure experimenter's current perception threshold
Experimenter 1 is subjected to the galvanism of 12 times different sizes altogether: 6 primary currents are ascending, and other 6 primary currents are descending.When stimulating current increases, stop to stimulate the threshold value limit in the time of to obtain an electric current increase with the pattern that goes out to experience stimulation from the electric-examination of experimenter's brain; When stimulating current reduces, go out impression with the electric-examination of experimenter's brain and stop to stimulate, the threshold value limit (shown in the experimental result table 1) in the time of can obtaining an electric current and reduce less than the pattern that stimulates.Like this, every time stimulation just can obtain a threshold value limit, and the meansigma methods of all threshold values limits is experimenter's current perception threshold (0.224mA).
Table 1
As another kind of embodiment, set up algorithm for pattern recognition after, adopt method of constant stimulus to measure experimenter's current perception threshold.
At first setting the stimulus intensity grade is 0.15,0.17,0.18,0.19,0.23,0.26,0.28,0.30 and 0.35mA; Each stimulus intensity grade is given with the experimenter stimulates (stimulation order random distribution) for 20 times, writes down post-stimulatory brain simultaneously; By brain electricity analytical, judge the pattern (experimental result such as Fig. 3) whether the brain electricity presents the experimenter and experience stimulation.Repeatedly stimulation for a certain strength grade, through corresponding brain electricity analytical, can obtain number of times percentage ratio (for example 20 of 0.26mA intensity stimulations among Fig. 3 that subject perception stimulates to this intensity, the brain electricity analytical result shows that subject perception has arrived wherein 6 times, so this subject perception is 30% to the percentage ratio of 0.26mA galvanism), operation definition according to the experimental psychology threshold of feelings, threshold value is that stimulus intensity that 50% number of times is felt, therefore we arrive the relation that stimulates number of times percentage ratio according to stimulus intensity shown in Figure 3 and subject perception, and the stimulus intensity meansigma methods 0.29mA that the number of times of calculating 50% is felt is as the measured value of experimenter's current perception threshold.
Claims (1)
1. the body current based on brain electricity analytical is felt threshold values objective measurement system, comprising:
Constant current control circuit (3): be used to send constant current;
Galvanism electrode (4): be used to conduct the constant current stimulation experimenter that the constant current control circuit sends;
Electrode for encephalograms (5): the EEG signals that is used to gather the experimenter;
Eeg amplifier (6): the EEG signals that is used for electrode for encephalograms is gathered is amplified;
Memorizer (7): be used to store EEG signals, algorithm for pattern recognition and signal processing results by after the eeg amplifier amplification;
Date processing/control master unit (2): be used to control the constant current control circuit and send constant current and the EEG signals of memorizer is carried out analyzing and processing;
Display (8): be used to show measurement process parameters and measurement result;
When measuring body current sensation threshold values, galvanism electrode (4) gives experimenter's varying strength galvanism, electrode for encephalograms (5) is gathered experimenter's EEG signals, date processing/control master unit (2) utilizes the algorithm for pattern recognition that prestores in the memorizer (7) that experimenter's EEG signals is divided into the EEG signals under the non-stimulated condition and EEG signals under the electricity irritation condition is arranged, and calculates experimenter's galvanism sensation threshold values again according to the ultimate value of the pairing current intensity of EEG signals under the different condition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101000489A CN101584582B (en) | 2009-06-25 | 2009-06-25 | Objective measurement method and system of human body current sensory threshold based on electrical brain analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101000489A CN101584582B (en) | 2009-06-25 | 2009-06-25 | Objective measurement method and system of human body current sensory threshold based on electrical brain analysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101584582A CN101584582A (en) | 2009-11-25 |
| CN101584582B true CN101584582B (en) | 2011-06-15 |
Family
ID=41369166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101000489A Expired - Fee Related CN101584582B (en) | 2009-06-25 | 2009-06-25 | Objective measurement method and system of human body current sensory threshold based on electrical brain analysis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101584582B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI622381B (en) * | 2013-03-28 | 2018-05-01 | Brain wave analysis method | |
| CN103246348B (en) * | 2013-04-03 | 2015-04-01 | 上海交通大学 | Quantitative analysis system and method for electric touches |
| US20200268304A1 (en) * | 2017-07-07 | 2020-08-27 | Shimadzu Corporation | Cognitive function determination method |
| CN112336353B (en) * | 2020-11-04 | 2023-07-28 | 西安科技大学 | Multistage attention grading method based on Shulter square and LSTM |
| CN114209355B (en) * | 2022-02-24 | 2022-06-10 | 深圳高性能医疗器械国家研究院有限公司 | Deep neural ultrasonic automatic positioning and mapping method, device, equipment and medium |
| CN116369949B (en) * | 2023-06-06 | 2023-09-15 | 南昌航空大学 | Electroencephalogram signal grading emotion recognition method, electroencephalogram signal grading emotion recognition system, electronic equipment and medium |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4305402A (en) * | 1979-06-29 | 1981-12-15 | Katims Jefferson J | Method for transcutaneous electrical stimulation |
| US5797854A (en) * | 1995-08-01 | 1998-08-25 | Hedgecock; James L. | Method and apparatus for testing and measuring current perception threshold and motor nerve junction performance |
| CN1537510A (en) * | 2003-04-16 | 2004-10-20 | 英属美帝普拉斯开发有限公司 | Objectively quantitative system for sensation of human body to electric current and its measuring method |
-
2009
- 2009-06-25 CN CN2009101000489A patent/CN101584582B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4305402A (en) * | 1979-06-29 | 1981-12-15 | Katims Jefferson J | Method for transcutaneous electrical stimulation |
| US5797854A (en) * | 1995-08-01 | 1998-08-25 | Hedgecock; James L. | Method and apparatus for testing and measuring current perception threshold and motor nerve junction performance |
| CN1537510A (en) * | 2003-04-16 | 2004-10-20 | 英属美帝普拉斯开发有限公司 | Objectively quantitative system for sensation of human body to electric current and its measuring method |
Non-Patent Citations (1)
| Title |
|---|
| 乐艳飞.人体电流感觉阈值客观测试方法的研究.《浙江大学硕士学位论文》.2006,第27-32页，图4-1至4-6. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101584582A (en) | 2009-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210282689A1 (en) | Intraoperative neurophysiological monitoring system | |
| CN101584582B (en) | Objective measurement method and system of human body current sensory threshold based on electrical brain analysis | |
| CN104768449B (en) | Device for examining a phase distribution used to determine a pathological interaction between different areas of the brain | |
| CN102319067B (en) | Nerve feedback training instrument used for brain memory function improvement on basis of electroencephalogram | |
| Wolf et al. | Intra-subject reliability of parameters contributing to maps generated by transcranial magnetic stimulation in able-bodied adults | |
| CN105899255B (en) | E.E.G measures and brains stimulating system | |
| CN104978035B (en) | Brain machine interface system and its implementation based on body-sensing electric stimulus inducing P300 | |
| WO2001032078A1 (en) | The control method and system and the sense organs test method and system based on electrical steady state induced response | |
| US11744514B2 (en) | Device and method for calibrating a non-invasive mechanically tactile and/or thermal neurostimulation | |
| CN103258120A (en) | Apoplexy recovery degree index calculation method based on brain electrical signals | |
| CN110192874B (en) | Lie detection method based on multi-lead electroencephalogram signal margin factors | |
| KR20130050817A (en) | Depression diagnosis method using hrv based on neuro-fuzzy network | |
| CN108335728A (en) | A kind of name of calling out for disturbance of consciousness patient promotees system of waking up | |
| CN102113879A (en) | Brainwave real-time evaluation system and evaluation method thereof | |
| CN110522999A (en) | Electric stimulation with Fatigue Assessment function | |
| KR102162054B1 (en) | Pain Analysis Device | |
| KR20140102879A (en) | Electro-acupuncture system | |
| KR101319440B1 (en) | Method for Analysis on Comparison of Eyesight, Auditory Sense, and Audio-visual Sense | |
| CN110192875B (en) | Lie detection method based on multi-lead electroencephalogram signal form factor | |
| Nawrocka et al. | 780. Biomedical signal identification and analysis | |
| Araújo et al. | Evaluation of motor neuron excitability by CMAP scanning with electric modulated current | |
| CN1923311A (en) | Human body acupuncture analgesia biological information conforming and feedback system | |
| CN113520310A (en) | Electroencephalogram ERP-based touch information processing method | |
| van Dijk | On the number of motor units. | |
| US20170245777A1 (en) | System and method for determining nociceptive withdrawal reflex threshold and quantifying a reflex receptive field |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110615 Termination date: 20180625 |