CN101626802A - 神经外科器械 - Google Patents

神经外科器械 Download PDF

Info

Publication number
CN101626802A
CN101626802A CN200780035158A CN200780035158A CN101626802A CN 101626802 A CN101626802 A CN 101626802A CN 200780035158 A CN200780035158 A CN 200780035158A CN 200780035158 A CN200780035158 A CN 200780035158A CN 101626802 A CN101626802 A CN 101626802A
Authority
CN
China
Prior art keywords
tube portion
conduit
tube
guide wire
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN200780035158A
Other languages
English (en)
Other versions
CN101626802B (zh
Inventor
史蒂文·斯特里特菲尔德·吉尔
马修·大卫·弗雷德里克·斯特拉顿
雨果·乔治·戴瑞克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Renishaw Ireland Ltd
Original Assignee
Renishaw PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renishaw PLC filed Critical Renishaw PLC
Priority to CN201310092806.3A priority Critical patent/CN103203064B/zh
Publication of CN101626802A publication Critical patent/CN101626802A/zh
Application granted granted Critical
Publication of CN101626802B publication Critical patent/CN101626802B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
    • A61B90/11—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0097—Catheters; Hollow probes characterised by the hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0004—Catheters; Hollow probes having two or more concentrically arranged tubes for forming a concentric catheter system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A61M2025/0046—Coatings for improving slidability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A61M2025/0046—Coatings for improving slidability
    • A61M2025/0047—Coatings for improving slidability the inner layer having a higher lubricity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • A61M2025/0046—Coatings for improving slidability
    • A61M2025/0047—Coatings for improving slidability the inner layer having a higher lubricity
    • A61M2025/0048—Coatings for improving slidability the inner layer having a higher lubricity with an outer layer made from silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0662—Guide tubes
    • A61M2025/0681—Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09083—Basic structures of guide wires having a coil around a core
    • A61M2025/09091—Basic structures of guide wires having a coil around a core where a sheath surrounds the coil at the distal part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0687—Skull, cranium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/005—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/005—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
    • A61M25/0053—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids having a variable stiffness along the longitudinal axis, e.g. by varying the pitch of the coil or braid

Abstract

一种用于插入脑部的导管组件。所述导管组件包括第一管部分，所述第一管部分由第一材料形成。所述第一管部分由第二材料环绕，所述第二材料的柔性比第一材料的柔性大，所述第二材料的E型洛氏硬度小于50。所述第二材料提供对第一管部分的减振。

Description

神经外科器械
技术领域
本发明涉及神经外科中使用的装置，具体而言，本发明设计用于将治疗药物输送到中枢神经系统的导管。
背景技术
血脑屏障对于向神经系统输送治疗试剂来说是一种明显的阻碍。术语治疗试剂包括具有治疗效果的物质，诸如药物化合物、遗传物质、生物制剂(即，利用活体器官诸如干细胞合成的制剂)。绕开该障碍的技术发展可以革命性地治疗帕金森综合症、亨廷顿综合症和阿耳茨海默氏病以及多形性成胶质细胞瘤。已经研制出了有希望抑制甚至反转这些疾病的基础病理学过程的新型试剂。但是，这些治疗试剂的局限性在于，借助传统方法(例如，口服或静脉内)输送时它们并不能穿过血脑屏障，因此无法到达脑部中有需求的结构。
对流增强输送(CED)允许直接向中枢神经系统输送治疗试剂，而不需要让治疗试剂穿过血脑屏障。CED利用纤细的颅内导管和较低的输注速率直接向脑细胞外间隙注入药物。与直接脑实质内注射、包被细胞和可生物降解聚合物形成对照，CED不依赖于扩散。使用精心设计的、具有精确受控的输注速率的套管会产生压力梯度，治疗试剂沿着压力梯度直接进入细胞外间隙。因此，即便对于相对较大的分子，也可以在较大体积的脑和脊髓上实现受控的均匀分布。
国际专利申请WO03/077764公开了在人类或非人类脑部植入导管用于脑实质内药物输送。因此，可以通过该导管向希望的脑部目标间歇性地或持续性地泵送药物。对于长期药物输送，包含储存器的泵可以皮下植入，并且该储存器可以根据需要通过可触知的端口经皮再填充。
1999年10月出版的Am J Physical Regal Integr Comp Physical vol 277Issue 4，R1218-R1229中的论文“在直接输注脑部期间的焦点输送：流速、导管直径和组织机械性能的作用”描述了通过直接填隙输注控制药物输送。
该论文披露了流体以低流速通过植入的导管，能够认为所有的输注溶液输送到目标阻止。但是，以高流速，溶液可以回流导管轴，泄漏到表面，减少了对组织的输送。
以这种高流速，注入物在围绕导管的组织上形成压力，并且使得组织移离导管的表面，由此形成沿着导管的一部分长度的环形间隙。如果该环形间隙足够长，其可变成延伸的输注源，并且扭曲输注物分布的球对称。在极端情况下，该环形间隙可以延伸到脑表面，丧失的输注物直接进入脑脊髓液。
CED的主要局限在于，药物通过细胞外间隙的分布是不可预知的。CED影响治疗试剂的药物分配的主要因素在于导管设计、输注流速、导管放置部位、治疗试剂的负荷以及非特定的治疗试剂粘合。尽管已经进行了多种临床试验来使用该技术对具有神经变性疾病的患者给予治疗试剂或者生物活性试剂，但是可获得的证据揭示，使用的导管与成功的CED不相容。
药物分布的不可预知的关键因素之一在于输注的试剂沿着导管的插入轨迹回流。Neurosurg Focus 20(3)：E12，2006-06-1-28中的论文“用于脑部疾病的治疗药物的对流增强输送及其优化”中披露了这种回流发生的两个原因之一。首先，如果导管以机械方式破坏组织足以允许围绕其外壁形成间隙，则会发生回流。在这种情况下，输注的试剂简单地沿着间隙回流，由此减小了输注物到达其所需的目标部位的百分比。这种回流会导致头皮坏死或者导致抗体发展。
即使当导管插入期间没有间隙形成或者当在外壁上密封时，也会发生第二种类型的回流。在这种固有的回流过程中，与输注过程有关的压力推靠在组织上并且使得组织从导管微小地分离，直到组织中的剪切力平衡压力长并且倒退的轴向流动停止。
本申请人旨在通过使用如WO03/077785中公开的小直径导管减小回流量。熔融石英有趣其低的病毒粘合特性是用于该导管的优选材料。这些特性是重要的，因为治疗试剂可能是病毒基的，例如会粘合到基材例如导管上的单纯疱疹，导致无效的输送。但是，已经显示，只有小百分比的病毒性输注会粘合到熔融石英上，因此熔融石英是用于输送的优选材料。
当流体在压力下流过导管时，导管经历振动。由刚性材料例如熔融石英制成的导管具有高的固有频率。当流体冲击导管时，其经历高频率小振幅的振动。导管的这种振动使得导管和其环绕的组织之间的间隙增加，由此增加了回流。
发明内容
根据本发明的第一方面，提供一种用于插入脑部的导管组件，所述导管组件包括第一管部分，所述第一管部分由第一材料形成，所述第一管部分由第二材料环绕，所述第二材料的柔性比第一材料的柔性大，所述第二材料的E型洛氏硬度小于50。
在一种优选实施方式中，所述第二材料包括与所述第一管部分同心的第二管部分。可替代的是，所述第二材料是所述第一管部分的部件。
所述组件可包括另一管部分，所述另一管部分与所述第一管部分同心，其中，在所述第二材料和所述另一管部分之间形成有环形间隙。
所述另一管部分可由柔性大于所述第一材料的材料形成。
所述第一管部分可以比所述另一管部分延伸的更长。
根据本发明的第二方面，提供一种用于插入脑部的导管组件，所述组件包括同心的内管部分和外管部分，在所述内管部分和外管部分之间存在环形间隙。
优选的是，所述同心的内管部分和外管部分都是刚性的。所述外管部分的弹性模量可以大于30GPa。
所述内管部分可包括熔融石英。所述外管部分可包括熔融石英。所述外管部分可包括不锈钢。
附图说明
以下将借助实例参照附图解释本发明的实施方式，其中：
图1示出了导引管的侧视图；
图2示出了内管的侧视图；
图3示出了导管的侧视图；
图4A示出了组装好的导引管、内管和导管的侧视图；
图4B示出了组装好的、插入脑部的导引管、内管和导管；和
图5示出了插入到脑部的导管、内管、和导引管的端部的剖视图。
具体实施方式
图1-3分别示出了根据本发明的导引管、内管和导管。
导引管10在图1中示出，包括一定长度的管12，一端具有接头(hub)14。在该实例中，导引管由聚氨酯塑料例如聚碳酸酯基聚氨酯(carbothane)55DB20制成。但是，导引管可以使用任何生物相容且在室温下刚性足够维持其中心孔的材料制成。在该实例中，管12的外径为0.6mm，内径为0.5mm。
导引管通过外科医生在颅骨上开设的孔(例如，钻孔)插入脑部。一旦该长度的管插入脑部，则接头可以连接到病人的颅骨，例如利用丙烯酸系胶粘剂粘接到颅骨的孔中。可以使用导线将导引管导入就位，正如WO03/077784所公开的。在插入之前，将导引管切割成到不了目标部位。导引管远端通常距离目标几个毫米。
导引管的接头优选呈拱形，并具有切开的狭缝16，该狭缝将所述管的中心孔与接头的侧部连接。
内管18在图2中示出，包括两段连接的管，远管20，其在本实例中外径为0.42mm，内径为0.2mm；和近管22，其直径较大。止动元件24连接近管和远管。远端管和近端管部分通常由聚氨酯塑料例如carbothane 85AB20制成，当然也可以使用其他材料制成。止动元件24在本实例中也用聚氨酯塑料例如carbothane 72DB20制成。当然也可以使用其他合适的材料。
止动元件24具有基本上为柱状的中心主体26和一对径向对置的翼部28、30，所述翼部各自包含埋头螺孔32、34，从而止动元件可以拧到病人颅骨外表面。带有远端管部分和近端管部分以及止动元件的内管在WO03/077785中描述地更为详细。
止动元件具有两种功能。首先，在将内管插入导引管时，止动元件抵靠导引管的接头，从而形成止动件并限定远管从导引管的管部延伸的长度。其次，止动元件的翼部用于将内管固定到病人的颅骨。
将内管固定到病人颅骨的功能可以用替代方式实现。例如，可以在近管上设置成对翼部，例如通过在该管上进行包覆成型(overmould)而设置。所述翼部可以设置有孔，以容纳螺钉，这些螺钉在拧入颅骨的时候将所述翼部和近管固定就位。这种布置允许一个翼部叠加在另一个翼部上面，以便将单个螺钉穿过所述翼部的两个孔而插入。这种布置的优势在于，导致对近管中的导管产生某种夹持。
导管36在图3中示出，包括纤细的管部分38，导管36通常用熔融的石英制成。可以使用惰性且病毒粘附性低的替代材料制造。熔融石英的外径通常为0.2mm，内径为0.1mm。导管在一端设置有棘突40，用作止动件。该棘突可以直接模制在导管上，并且可以用聚氨酯塑料例如carbothane制成。
棘突40具有阶梯柱状轮廓，并带有中心孔。直径最大的区域41具有平直侧部，形成止挡件，当导管插入内管时，近管的端部抵靠该止挡件。在直径最大的区域的另一侧是柱状部分43，带有直径减小的收敛部分45。使用中，将管推入柱状部分，直到其抵靠直径最大的区域41。当管经过收敛部分45时，其变形从而形成密封件。当导管36插入内管18时，推压近管22的端部穿过其中一个柱状部分43。将导管连接到泵的连接管(未示出)可以通过相同的方式连接到棘突的另一个柱状部分。
为了进行神经外科手术，医生首先需要了解病人的神经解剖学结构，从而辨别希望的目标位置。通常将立体定向基准框架固定到病人头部来实现，可以在诊断图像上观察到该框架的元件，并且可以由此进行测量。立体定向框架然后作为平台，可以利用设置在所测量的坐标的立体导向件将仪器从该平台导入希望的目标。一旦将仪器导入希望的目标，则开始治疗。在WO03/077784中有更为详细的描述。
利用固紧的立体导向件，将导引管插入脑部并固定就位，如上所述。图4A和图4B示出了组装好的导引管10、内管18和导管36。图4A是位于颅骨外侧的该组件，而图4B是导管插入脑部42后的该组件。图4B示出了通过骨胶粘剂46在颅骨44的孔中固定就位的导引管10的接头14。将远管20插入导引管10，直到止动元件24抵靠导引管的接头14，从而将内管插入导引管。止动元件24因此作为止动件，控制插入脑部的内管长度。导管36插入内管并推动导管，直到其棘突抵靠内管的近管22的端部。
一旦导引管、内管和导管全部插入，则包含从导引管的接头延伸出颅骨的导管的近管弯曲90度，以使止动元件靠着颅骨放平，如图4B所示。然后利用穿过埋头螺孔的螺钉48将其固定就位。导引管的接头14上切开的狭缝16允许进行90度弯曲。可以在内管上设置额外的固定装置(例如包覆成型在内管上的翼部)进行额外的夹持，螺钉通过该另外的固定装置连接到颅骨。
导引管、内管和导管的长度布置成让内管延伸到脑部的长度大于导引管(例如，10mm)且导管延伸到脑部的长度大于内管(例如，10mm)。
在导引管、内管和导管全部就位的情况下，可以经由连接管将导管连接到泵(未示出)，该连接管连接到导管的棘突。
这种布置的优点在于，其最小化了导管的振动，下面将参照图5对其进行描述，该图示出了插入到脑部的导管、内管和导引管的端部的放大图。
当导引管插入到脑部时，其会充满脑脊髓液(CSF)。导引管中的脑脊髓液的量沿着其长度变化。当内管和导管插入到导引管中时，在导引管的管12和内管的远端管20之间形成环形间隙50，该环形间隙含有脑脊髓液。在该实例中，环形间隙50大致为0.01mm。当治疗试剂泵送到导管的端部并进入脑组织时，可能会沿着导管和内管的外表面发生一些回流，该回流中的一些治疗试剂会通过毛细作用进入内管和外管之间的环形间隙。内管和导引管之间的流体具有减振作用，减小了导管和内管的振动。因此，同心的管和管之间的环形间隙的布置，形成了减振效果。
在该实施方式中，导管由相对刚性的材料形成，例如熔融石英，内管由更柔性的材料(即carbothane 85AB20)形成。在内管中比在导管中使用更柔性的材料也提供了减振作用，由此减小或者消除了内管和外管的振动。
在一种替代实施方式中，熔融石英导管可以用更柔性的物质例如聚氨酯包覆成型，以产生相同的效果。
Thermedics CarbothaneTM PC-3572D-B20聚碳酸酯基聚氨酯BiomedicalElaster的D型肖氏硬度为71。E型洛氏硬度小于50的材料提供足够的减振。
另一种合适的材料是PEEK optima(由INVIBIO生产)，其M型洛氏硬度为99(在其粒状形态)。
导引管由比导管更柔性的材料形成(即carbothane 85AB20)，这也形成了减振效果。
内管对于本发明不是必须的，导管可以直接插入到导引管中。导引管的柔性材料和导引管与导管直接的环形间隙两者都提供了对导管的减振。
内管可以由刚性材料制成，例如，其具有大于30GPa的弹性模量。例如熔融石英，其弹性模量为35-40GPa，或者适于外科器械或者植入手术的不锈钢，其弹性模量为190-200GPa。通过刚性内管，导管和内管之间的环形间隙中的流体提供了减振。可替代的是，导管可以直接插入导引管中，而不需要内管，在这种情况下，导引管可以有具有上面描述的性质的刚性材料制成。

Claims (27)

1.一种用于插入脑部的导管组件，所述导管组件包括第一管部分，所述第一管部分由第一材料形成，所述第一管部分由第二材料环绕，所述第二材料的柔性比第一材料的柔性大，所述第二材料的E型洛氏硬度小于50。
2.根据权利要求1所述的导管组件，其特征在于，所述第二材料包括与所述第一管部分同心的第二管部分。
3.根据权利要求1所述的导管组件，其特征在于，所述第二材料是所述第一管部分的部件。
4.根据权利要求3所述的导管组件，其特征在于，所述第二材料模制到所述第一管部分上。
5.根据权利要求1或者2所述的导管组件，其特征在于，所述组件包括另一管部分，所述另一管部分与所述第一管部分同心。
6.根据权利要求5所述的导管组件，其特征在于，所述另一管部分由柔性大于所述第一材料的材料形成。
7.根据权利要求5或者6所述的导管组件，其特征在于，在所述第二材料和所述另一管部分之间形成有环形间隙。
8.根据权利要求2所述的导管组件，其特征在于，在所述第一管部分和第二管部分之间形成有环形间隙。
9.根据前述权利要求中任一项权利要求所述的导管组件，其特征在于，所述第一材料是熔融石英。
10.根据前述权利要求中任一项权利要求所述的导管组件，其特征在于，所述第二材料是聚碳酸酯基聚氨酯。
11.根据权利要求2所述的导管组件，其特征在于，所述第一材料是熔融石英，所述第二材料是聚碳酸酯基聚氨酯，所述第一管部分具有聚酰亚胺涂层。
12.一种用于插入脑部的导管套件，所述导管套件包括第一管部分和第二管部分，所述第一管部分由第一材料形成，所述第二管部分由第二材料形成，所述第二材料的柔性比所述第一材料的柔性大，所述第二材料的E型洛氏硬度小于50，所述第一管部分和第二管部分的尺寸设计成使得所述第一管部分能够插入到所述第二管部分中。
13.根据权利要求12所述的导管套件，其特征在于，所述第一材料是熔融石英。
14.根据权利要求12所述的导管套件，其特征在于，所述第二材料是聚碳酸酯基聚氨酯。
15.根据权利要求13所述的导管套件，其特征在于，所述第一管部分具有聚酰亚胺涂层。
16.根据权利要求12到15中任一项权利要求所述的导管套件，其特征在于，所述第一管部分和第二管部分的尺寸被设计成使得当所述第一管部分插入到所述第二管部分中时在所述第一管部分和第二管部分之间形成有环形间隙。
17.一种用于插入脑部的导管组件，所述组件包括同心的内管部分和外管部分，在所述内管部分和外管部分之间存在环形间隙。
18.根据权利要求17所述的导管组件，其特征在于，所述同心的内管部分和外管部分都是刚性的。
19.根据权利要求17到18中任一项权利要求所述的导管组件，其特征在于，所述外管部分的弹性模量大于30GPa。
20.根据权利要求17到19中任一项权利要求所述的导管组件，其特征在于，所述内管部分包括熔融石英。
21.根据权利要求17到20中任一项权利要求所述的导管组件，其特征在于，所述外管部分包括熔融石英。
22.根据权利要求17到20中任一项权利要求所述的导管组件，其特征在于，所述外管部分包括不锈钢。
23.根据权利要求17到22中任一项权利要求所述的导管组件，其特征在于，所述内管部分包括导管，所述外管部分包括导引管。
24.一种用于插入脑部的导管套件，所述套件包括导管和导引管，所述导管的尺寸允许插入到所述导引管中，在所述导管和导引管之间形成有环形间隙，其中，所述导引管的弹性模量大于30GPa
25.根据权利要求24所述的导管套件，其特征在于，所述导引管包括熔融石英。
26.根据权利要求24所述的导管套件，其特征在于，所述导引管包括不锈钢。
27.根据权利要求24到27中任一项权利要求所述的导管套件，其特征在于，所述导管包括熔融石英。
CN2007800351580A 2006-08-18 2007-08-20 神经外科器械 Expired - Fee Related CN101626802B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201310092806.3A CN103203064B (zh) 2006-08-18 2007-08-20 神经外科器械

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0616411.5A GB0616411D0 (en) 2006-08-18 2006-08-18 Neurosurgical instruments
GB0616411.5 2006-08-18
PCT/GB2007/003178 WO2008020241A2 (en) 2006-08-18 2007-08-20 Neurosurgical instruments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201310092806.3A Division CN103203064B (zh) 2006-08-18 2007-08-20 神经外科器械

Publications (2)

Publication Number Publication Date
CN101626802A true CN101626802A (zh) 2010-01-13
CN101626802B CN101626802B (zh) 2013-07-03

Family

ID=37081179

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201310092806.3A Active CN103203064B (zh) 2006-08-18 2007-08-20 神经外科器械
CN200780034915A Pending CN101626801A (zh) 2006-08-18 2007-08-20 神经学装置
CN2007800351580A Expired - Fee Related CN101626802B (zh) 2006-08-18 2007-08-20 神经外科器械

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN201310092806.3A Active CN103203064B (zh) 2006-08-18 2007-08-20 神经外科器械
CN200780034915A Pending CN101626801A (zh) 2006-08-18 2007-08-20 神经学装置

Country Status (8)

Country Link
US (4) US20100217236A1 (zh)
EP (3) EP2601997B1 (zh)
JP (3) JP5216770B2 (zh)
CN (3) CN103203064B (zh)
ES (1) ES2497967T3 (zh)
GB (1) GB0616411D0 (zh)
PL (1) PL2601997T3 (zh)
WO (2) WO2008020237A2 (zh)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2572661B1 (en) 2004-10-05 2019-11-20 Genzyme Corporation Stepped cannula
WO2007024841A2 (en) 2005-08-23 2007-03-01 The Regents Of The University Of California Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
GB0616411D0 (en) 2006-08-18 2006-09-27 Renishaw Plc Neurosurgical instruments
GB0623395D0 (en) 2006-11-23 2007-01-03 Renishaw Plc Port
US9105673B2 (en) 2007-05-09 2015-08-11 Brooks Automation, Inc. Side opening unified pod
US8834446B2 (en) 2008-06-12 2014-09-16 DePuy Synthes Products, LLC Pulsatile flux drug delivery
US9693799B2 (en) 2009-09-17 2017-07-04 Pilofocus, Inc. System and method for aligning hair follicle
US9314082B2 (en) 2009-09-17 2016-04-19 Pilofocus, Inc. System and method for extraction of hair follicle
BR112012006157A2 (pt) 2009-09-17 2016-06-28 Carlos K Wesley cirurgia de restauração de cabelo.
GB201002370D0 (en) * 2010-02-12 2010-03-31 Renishaw Ireland Ltd Percutaneous drug delivery apparatus
PL2558154T3 (pl) 2010-04-16 2020-11-30 Clearpoint Neuro, Inc. Systemy chirurgiczne MRI zawierające kaniule chirurgiczne kompatybilne z MRI do transferu substancji do i/lub od pacjenta
EP2739341B1 (en) 2011-08-01 2021-02-17 Alcyone Lifesciences, Inc. Microfluidic drug delivery devices
GB201117061D0 (en) 2011-10-04 2011-11-16 Renishaw Ireland Ltd Neurosurgical apparatus
CN104114110A (zh) 2011-10-17 2014-10-22 皮洛福克斯有限公司 头发修复
GB201203426D0 (en) * 2012-02-28 2012-04-11 Renishaw Plc Neurosurgical apparatus
WO2014016591A1 (en) * 2012-07-24 2014-01-30 Renishaw Plc Neurosurgical apparatus and methods
JP2015523172A (ja) 2012-07-27 2015-08-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 微量注入カテーテル
US8992458B2 (en) 2012-12-18 2015-03-31 Alcyone Lifesciences, Inc. Systems and methods for reducing or preventing backflow in a delivery system
DE102013101538C5 (de) * 2013-02-15 2019-03-28 Pajunk GmbH Medizintechnologie Set für die periphere Nervenblockade
JP2016522069A (ja) 2013-06-17 2016-07-28 アルキオーネ・ライフサイエンシズ・インコーポレイテッドＡｌｃｙｏｎｅ Ｌｉｆｅｓｃｉｅｎｃｅｓ， Ｉｎｃ． カテーテル先端部を保護する方法および装置ならびにマイクロカテーテル用の定位固定物
JP6498670B2 (ja) 2013-07-31 2019-04-10 アルキオーネ・ライフサイエンシズ・インコーポレイテッドＡｌｃｙｏｎｅ Ｌｉｆｅｓｃｉｅｎｃｅｓ， Ｉｎｃ． 薬剤送達、治療、およびモニタリングのためのシステムおよび方法
US9891296B2 (en) 2013-09-13 2018-02-13 MRI Interventions, Inc. Intrabody fluid transfer devices, systems and methods
KR101405610B1 (ko) * 2013-10-08 2014-06-13 국립암센터 두개골 이식형 약물 주입 포트
GB201404978D0 (en) 2014-03-20 2014-05-07 Renishaw Plc Neurosurgical apparatus
US10758264B2 (en) * 2014-11-13 2020-09-01 The Regents Of The University Of California Adjustable stepped cannula
US10806396B2 (en) 2015-01-26 2020-10-20 Alcyone Lifesciences, Inc. Drug delivery methods with tracer
DE102015117923A1 (de) * 2015-07-29 2017-02-02 Jens Ebnet Punktionssystem
CN108472019A (zh) 2016-01-04 2018-08-31 亚克安娜生命科学有限公司 用于治疗中风的方法和装置
WO2017142698A1 (en) 2016-02-17 2017-08-24 MRI Interventions, Inc. Intrabody surgical fluid transfer assemblies with adjustable exposed cannula to needle tip length, related systems and methods
CA3035522A1 (en) 2016-08-30 2018-03-08 The Regents Of The University Of California Methods for biomedical targeting and delivery and devices and systems for practicing the same
US11690645B2 (en) 2017-05-03 2023-07-04 Medtronic Vascular, Inc. Tissue-removing catheter
CN114948106A (zh) 2017-05-03 2022-08-30 美敦力瓦斯科尔勒公司 具有导丝隔离衬套的组织移除导管
WO2019010578A1 (en) * 2017-07-13 2019-01-17 The University Of Western Ontario COAXIAL NEEDLE SYSTEM
WO2019018342A1 (en) 2017-07-17 2019-01-24 Voyager Therapeutics, Inc. NETWORK EQUIPMENT TRACK GUIDE SYSTEM
EP3781074A1 (en) 2018-05-09 2021-02-24 ClearPoint Neuro, Inc. Mri compatible intrabody fluid transfer systems and related devices and methods
US11253237B2 (en) 2018-05-09 2022-02-22 Clearpoint Neuro, Inc. MRI compatible intrabody fluid transfer systems and related devices and methods
CN108815588B (zh) * 2018-07-16 2020-12-25 中国科学技术大学 一种自聚焦透镜用于脑区成像的包被方法
US11357534B2 (en) 2018-11-16 2022-06-14 Medtronic Vascular, Inc. Catheter
US11819236B2 (en) 2019-05-17 2023-11-21 Medtronic Vascular, Inc. Tissue-removing catheter
US11684750B2 (en) 2019-10-08 2023-06-27 Clearpoint Neuro, Inc. Extension tube assembly and related medical fluid transfer systems and methods
US20230310799A1 (en) * 2022-03-29 2023-10-05 Clearpoint Neuro, Inc. Surgical systems including flexible mri-compatible surgical catheters for transferring a substance to and/or from a brain of a patient

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595239A (en) * 1969-04-04 1971-07-27 Roy A Petersen Catheter with electrical cutting means
US3995628A (en) 1975-04-25 1976-12-07 Travenol Laboratories, Inc. Catheter insertion device
US4160451A (en) 1977-11-25 1979-07-10 Abbott Laboratories Unidirectional catheter placement unit
US4230123A (en) * 1978-10-31 1980-10-28 Hawkins Jr Irvin F Needle sheath complex and process for decompression and biopsy
US4446866A (en) * 1982-03-10 1984-05-08 Warner-Lambert Company Microsurgical needle holder
JPS5973A (ja) * 1982-06-25 1984-01-05 立花　俊郎 超音波搬送管
FR2530958A1 (fr) 1982-07-29 1984-02-03 Lacour Gayet Francois Catheter cylindrique a un ou plusieurs canaux
GB2132898B (en) 1983-01-04 1986-09-24 James Bernard Bristol Cannula-trocar assembly
JPS6073547U (ja) * 1983-10-28 1985-05-23 松本　悟 脳室カテ−テル
US4659329A (en) * 1984-07-27 1987-04-21 The Kendall Company Liquid drainage system
US4850974A (en) * 1984-10-11 1989-07-25 Baxter International Inc. Dispenser and method for an elongated flexible member
JPS61187871A (ja) * 1985-02-14 1986-08-21 テルモ株式会社 カテ−テル
US4613324A (en) * 1985-06-17 1986-09-23 Ghajar Jamshid B G Method and apparatus for guiding catheter into ventricular system of human brain
JPH0676639B2 (ja) * 1986-03-28 1994-09-28 三菱マテリアル株式会社 円形への曲げが可能な超高靭性炭化タングステン基超硬合金線材
US4739768B2 (en) 1986-06-02 1995-10-24 Target Therapeutics Inc Catheter for guide-wire tracking
EP0266091A3 (en) 1986-10-20 1988-07-13 City Of Hope National Medical Center Anchoring mechanism for an adjustable length percutaneous drainage catheter
US5312356A (en) * 1989-05-22 1994-05-17 Target Therapeutics Catheter with low-friction distal segment
JPH0323010A (ja) * 1989-06-21 1991-01-31 Nippon Steel Corp 伸線ダイスおよびその製造方法
JP2540211B2 (ja) * 1989-07-10 1996-10-02 テルモ株式会社 ガイドワイヤ―
US5207648A (en) * 1990-12-14 1993-05-04 The Kendall Company Multilumen catheter
EP0492361B1 (en) * 1990-12-21 1996-07-31 Advanced Cardiovascular Systems, Inc. Fixed-wire dilatation catheter with rotatable balloon assembly
US5695510A (en) * 1992-02-20 1997-12-09 Hood; Larry L. Ultrasonic knife
US5380290A (en) 1992-04-16 1995-01-10 Pfizer Hospital Products Group, Inc. Body access device
US5257999A (en) * 1992-06-04 1993-11-02 Slanetz Jr Charles A Self-oriented laparoscopic needle holder for curved needles
US5993470A (en) * 1992-09-15 1999-11-30 Yoon; Inbae Universal handle for medical instruments
US5284472A (en) * 1992-10-30 1994-02-08 Allergan, Inc. Vitreous cutter
US5437644A (en) * 1993-05-26 1995-08-01 Visioneering, Inc. Method and apparatus for replacing a cannula
US5409455A (en) * 1993-07-09 1995-04-25 Scimed Life Systems, Inc. Vascular navigation and visualization assist device
NL9301642A (nl) 1993-09-22 1995-04-18 Cordis Europ Microcatheter.
US5507760A (en) * 1993-11-09 1996-04-16 Devices For Vascular Intervention, Inc. Cutter device
EP0671221B1 (en) * 1994-03-11 2000-04-26 Intravascular Research Limited Ultrasonic transducer array and method of manufacturing the same
CA2205666A1 (en) * 1994-11-23 1996-05-30 Micro Interventional Systems, Inc. High torque balloon catheter
DE19502183C1 (de) * 1995-01-25 1996-08-14 Wolfgang Dr Fleckenstein Halterungsvorrichtung für Gehirnmeßsonden
US5964740A (en) 1996-07-09 1999-10-12 Asahi Kogaku Kogyo Kabushiki Kaisha Treatment accessory for an endoscope
SE505822C2 (sv) * 1996-05-23 1997-10-13 Elekta Ab Anordning för att injicera en substans i en kropp, speciellt human eller animalisk
US5925039A (en) * 1996-06-12 1999-07-20 Iti Medical Technologies, Inc. Electrosurgical instrument with conductive ceramic or cermet and method of making same
US6106473A (en) * 1996-11-06 2000-08-22 Sts Biopolymers, Inc. Echogenic coatings
US5797858A (en) * 1997-03-14 1998-08-25 Hewlett-Packard Company Spooling pullback for catheter imaging and therapy cores
US6080134A (en) * 1997-05-13 2000-06-27 Camino Neurocare, Inc. Expandable parenchymal bolt with lever activation
US6030369A (en) * 1997-07-03 2000-02-29 Target Therapeutics Inc. Micro catheter shaft
EP1015045A2 (en) * 1997-08-22 2000-07-05 Direct Therapeutics, Inc. An apparatus for preventing loss of a composition during a medical procedure
GB2330078A (en) 1997-10-08 1999-04-14 David Brian Ashton Hutchinson Bolt for facilitating catheter insertion
US6086008A (en) * 1997-12-22 2000-07-11 Deka Products Limited Partnership Apparatus and method for permitting introduction and withdrawal of a catheter
US6296633B1 (en) 1998-01-09 2001-10-02 Schneider (Usa) Inc. Medical device tubing assembly and method of making the same
US6044304A (en) 1998-04-29 2000-03-28 Medtronic, Inc. Burr ring with integral lead/catheter fixation device
US6387060B1 (en) * 1998-06-17 2002-05-14 Advanced Cardiovascular Systems, Inc. Composite radiopaque intracorporeal product
US6203537B1 (en) * 1999-02-04 2001-03-20 Sorin Adrian Laser-driven acoustic ablation catheter
US6425805B1 (en) * 1999-05-21 2002-07-30 Kennametal Pc Inc. Superhard material article of manufacture
GB9925860D0 (en) 1999-11-01 1999-12-29 Hutchinson David B A Monitoring device
GB9928248D0 (en) 1999-12-01 2000-01-26 Gill Steven S An implantable guide tube for neurosurgery
US20010031981A1 (en) * 2000-03-31 2001-10-18 Evans Michael A. Method and device for locating guidewire and treating chronic total occlusions
EP1274377A2 (en) * 2000-04-07 2003-01-15 The General Hospital Corporation doing business as Massachusetts General Hospital Methods and apparatus for thermally affecting tissue
JP2002095755A (ja) * 2000-07-06 2002-04-02 Japan Lifeline Co Ltd 医療用ガイドワイヤ
US20020129989A1 (en) 2000-07-12 2002-09-19 Mark Parsons Stethoscope sound isolation headset
US20040073154A1 (en) * 2000-07-25 2004-04-15 Borgesen Svend Erik Ventricle drain
US6582400B1 (en) 2000-10-24 2003-06-24 Scimed Life Systems, Inc. Variable tip catheter
US20020188310A1 (en) * 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
ES2274984T3 (es) * 2001-07-05 2007-06-01 Precision Vascular Systems, Inc. Dispositivo medico de punta blanda que puede someterse a torsion y metodo para conformarlo.
US6863678B2 (en) * 2001-09-19 2005-03-08 Advanced Cardiovascular Systems, Inc. Catheter with a multilayered shaft section having a polyimide layer
US20040073158A1 (en) 2001-12-12 2004-04-15 Medtronic, Inc. Guide catheter
US7065394B2 (en) * 2001-12-12 2006-06-20 Medtronic, Inc Guide catheter
GB0205772D0 (en) 2002-03-12 2002-04-24 Gill Steven S Catheter
GB0205773D0 (en) 2002-03-12 2002-04-24 Gill Steven S Clamp
US20050256508A1 (en) * 2002-05-07 2005-11-17 Cardiac Pacemakers, Inc. Guide catheter system having relative markings
US7951089B2 (en) 2002-05-31 2011-05-31 Vidacare Corporation Apparatus and methods to harvest bone and bone marrow
WO2004016290A2 (en) * 2002-08-19 2004-02-26 Pappas Surgical Instruments Llc Pathogen resistant carbide surgical tools
DE10251413B3 (de) * 2002-11-01 2004-03-25 Sandvik Ab Verwendung eines korrosionsbeständigen, martensitisch aushärtenden Stahls
WO2004042327A2 (en) * 2002-11-04 2004-05-21 Transform Pharmaceuticals, Inc. Method and apparatus for manipulating and measuring solids
JP4275931B2 (ja) * 2002-11-26 2009-06-10 エヌ・ティ・ティ・アドバンステクノロジ株式会社 超微細径ワイヤーの加工方法
US20040215143A1 (en) 2003-01-13 2004-10-28 Martin Brady Hollow stylet for infusion catheter systems, devices and methods
US20050261673A1 (en) * 2003-01-15 2005-11-24 Medtronic, Inc. Methods and apparatus for accessing and stabilizing an area of the heart
US20040152045A1 (en) * 2003-02-03 2004-08-05 Benjamin Kachalon PCD dental drill bit
EP1462141B1 (en) * 2003-03-26 2006-09-20 Terumo Kabushiki Kaisha Catheter with puncture sensor
US7241283B2 (en) * 2003-04-25 2007-07-10 Ad-Tech Medical Instrument Corp. Method for intracranial catheter treatment of brain tissue
US7815975B2 (en) * 2003-06-25 2010-10-19 Volcano Corporation Catheter having polymer stiffener rings and method of making the same
US7311697B2 (en) * 2003-07-02 2007-12-25 Cook Critical Care Incorporated Central venous catheter
US6926711B2 (en) * 2003-07-30 2005-08-09 Cryocor, Inc. Articulating catheter for cryoablation with reduced diameter section
US20050061329A1 (en) * 2003-09-18 2005-03-24 Conceptus, Inc. Catheter for intrafallopian contraceptive delivery
AU2004283727A1 (en) * 2003-10-23 2005-05-06 Trans1 Inc. Tools and tool kits for performing minimally invasive procedures on the spine
US7972350B2 (en) * 2004-01-29 2011-07-05 Boston Scientific Scimed, Inc. Catheter tip
US7488322B2 (en) * 2004-02-11 2009-02-10 Medtronic, Inc. High speed surgical cutting instrument
US7172604B2 (en) * 2004-03-09 2007-02-06 Cole John P Follicular extraction punch and method
JP2005323658A (ja) 2004-05-12 2005-11-24 Kaneka Corp 医療用カテーテルチューブならびにその製造方法
WO2006015091A2 (en) * 2004-07-28 2006-02-09 University Of Virginia Patent Foundation Coaxial catheter systems for transference of medium
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
EP2572661B1 (en) * 2004-10-05 2019-11-20 Genzyme Corporation Stepped cannula
US9216015B2 (en) * 2004-10-28 2015-12-22 Vycor Medical, Inc. Apparatus and methods for performing brain surgery
US20080109026A1 (en) * 2004-10-28 2008-05-08 Strategic Technology Assessment Group Apparatus and Methods for Performing Brain Surgery
US20060217664A1 (en) * 2004-11-15 2006-09-28 Hattler Brack G Telescoping vascular dilator
US20060129126A1 (en) 2004-11-19 2006-06-15 Kaplitt Michael G Infusion device and method for infusing material into the brain of a patient
US7614938B1 (en) * 2005-02-22 2009-11-10 Pappas Iii John C Reconditioned medical devices
EP1874216B1 (en) * 2005-04-14 2011-12-28 Medtronic Image-Guided Neurologics, Inc. Composite mr-compatible stylet
CN1672649A (zh) 2005-04-16 2005-09-28 何明利 一种脑脊液穿刺引流器
WO2007024841A2 (en) 2005-08-23 2007-03-01 The Regents Of The University Of California Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
US8062298B2 (en) * 2005-10-15 2011-11-22 Baxano, Inc. Flexible tissue removal devices and methods
US20080086034A1 (en) * 2006-08-29 2008-04-10 Baxano, Inc. Tissue Access Guidewire System and Method
GB0604929D0 (en) * 2006-03-13 2006-04-19 Renishaw Plc Method and apparatus for fluid delivery
GB0604952D0 (en) * 2006-03-13 2006-04-19 Renishaw Plc A fluid connector for fluid delivery apparatus
US7998128B2 (en) 2006-05-15 2011-08-16 Therataxis, LLC. Active delivery and flow redirection: novel devices and method of delivery of materials to patients
GB0616411D0 (en) 2006-08-18 2006-09-27 Renishaw Plc Neurosurgical instruments
US7766875B2 (en) 2007-09-28 2010-08-03 Codman & Shurtleff, Inc. Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent
GB0802634D0 (en) 2008-02-13 2008-03-19 Renishaw Plc Catheter
CN101896220A (zh) 2007-10-08 2010-11-24 瑞尼斯豪(爱尔兰)有限公司 导管
US8480626B2 (en) 2007-11-30 2013-07-09 Medtronic, Inc. Infusion catheter assembly with reduced backflow
US20130158578A1 (en) 2010-09-03 2013-06-20 University Of Washington Neurosurgical devices and associated systems and methods
US8992458B2 (en) 2012-12-18 2015-03-31 Alcyone Lifesciences, Inc. Systems and methods for reducing or preventing backflow in a delivery system

Also Published As

Publication number Publication date
JP2013150812A (ja) 2013-08-08
US9452241B2 (en) 2016-09-27
CN103203064A (zh) 2013-07-17
JP2010501233A (ja) 2010-01-21
GB0616411D0 (en) 2006-09-27
CN101626801A (zh) 2010-01-13
US10857327B2 (en) 2020-12-08
WO2008020241A2 (en) 2008-02-21
CN101626802B (zh) 2013-07-03
EP2066364A2 (en) 2009-06-10
US20160346505A1 (en) 2016-12-01
EP2066364B1 (en) 2013-04-17
EP2601997A1 (en) 2013-06-12
JP2010501232A (ja) 2010-01-21
PL2601997T3 (pl) 2014-11-28
EP2601997B1 (en) 2014-08-13
US20120123391A1 (en) 2012-05-17
CN103203064B (zh) 2017-06-09
WO2008020237A3 (en) 2009-08-13
US20100217236A1 (en) 2010-08-26
JP5642823B2 (ja) 2014-12-17
WO2008020241A3 (en) 2009-08-13
WO2008020237A2 (en) 2008-02-21
JP5216770B2 (ja) 2013-06-19
US20090198218A1 (en) 2009-08-06
ES2497967T3 (es) 2014-09-23
EP2056896A2 (en) 2009-05-13

Similar Documents

Publication Publication Date Title
CN101626802B (zh) 神经外科器械
JP5701612B2 (ja) カテーテル
RU2442617C2 (ru) Конвекционный доставляющий катетер со съемным элементом жесткости и способ его применения
JP6498670B2 (ja) 薬剤送達、治療、およびモニタリングのためのシステムおよび方法
AU2003223187B2 (en) Vesicular shunt for the drainage of excess fluid
EP2252343B1 (en) Implantable access for removal and/or return of fluids
JP6339317B2 (ja) 液体管理カテーテル及びその使用方法
US7896852B2 (en) Anti-infective central venous catheter with diffusion barrier layer
CA2389028A1 (en) Catheter with stylet lumen
CN116209487A (zh) 用于将流体递送到内耳的装置、系统和方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: RENISHAW (IRELAND) CO., LTD.

Free format text: FORMER OWNER: RENISHAW PLC

Effective date: 20100601

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: GLOUCESTERSHIRE, THE UNITED KINGDOM TO: SWORDS, IRELAND

TA01 Transfer of patent application right

Effective date of registration: 20100601

Address after: Irish Swords

Applicant after: RENISHAW (IRELAND) Ltd.

Address before: Gloucestershire

Applicant before: Renishaw PLC

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130703

Termination date: 20210820