CN101801405A - 包含于酸性水溶液中的gdf-5的蛋白质配方 - Google Patents
包含于酸性水溶液中的gdf-5的蛋白质配方 Download PDFInfo
- Publication number
- CN101801405A CN101801405A CN200880101944A CN200880101944A CN101801405A CN 101801405 A CN101801405 A CN 101801405A CN 200880101944 A CN200880101944 A CN 200880101944A CN 200880101944 A CN200880101944 A CN 200880101944A CN 101801405 A CN101801405 A CN 101801405A
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- China
- Prior art keywords
- gdf
- solution
- hcl
- acid
- protein
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Abstract
Description
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95441307P | 2007-08-07 | 2007-08-07 | |
US60/954,413 | 2007-08-07 | ||
PCT/US2008/070137 WO2009020744A1 (en) | 2007-08-07 | 2008-07-16 | Protein formulations comprising gdf-5 in aqueous acidic solution |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101801405A true CN101801405A (zh) | 2010-08-11 |
Family
ID=39765213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200880101944A Pending CN101801405A (zh) | 2007-08-07 | 2008-07-16 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8058237B2 (zh) |
EP (1) | EP2187932B1 (zh) |
JP (1) | JP5323832B2 (zh) |
CN (1) | CN101801405A (zh) |
CA (1) | CA2695697A1 (zh) |
WO (1) | WO2009020744A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
JP5323832B2 (ja) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 酸性水溶液中にgdf−5を含むタンパク質製剤 |
CA2720845A1 (en) * | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
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EP2019117A1 (en) | 2007-07-27 | 2009-01-28 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Optimized purification process of recombinant growth factor protein |
FR2919188B1 (fr) | 2007-07-27 | 2010-02-26 | Proteins & Peptides Man | Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps |
GB2451451A (en) | 2007-07-30 | 2009-02-04 | Inion Ltd | Osteogenic compounds |
JP5323832B2 (ja) | 2007-08-07 | 2013-10-23 | アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー | 酸性水溶液中にgdf−5を含むタンパク質製剤 |
CA2707483A1 (en) | 2007-11-30 | 2009-06-11 | Wolfgang Fraunhofer | Protein formulations and methods of making same |
CA2720845A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
US8183233B2 (en) | 2008-05-15 | 2012-05-22 | Baxter International Inc. | Stable pharmaceutical formulations |
WO2010017296A1 (en) | 2008-08-05 | 2010-02-11 | Wyeth | Lyophilization above collapse |
-
2008
- 2008-07-16 JP JP2010520058A patent/JP5323832B2/ja not_active Expired - Fee Related
- 2008-07-16 CA CA2695697A patent/CA2695697A1/en not_active Abandoned
- 2008-07-16 EP EP08781884.5A patent/EP2187932B1/en not_active Not-in-force
- 2008-07-16 WO PCT/US2008/070137 patent/WO2009020744A1/en active Application Filing
- 2008-07-16 US US12/174,168 patent/US8058237B2/en not_active Expired - Fee Related
- 2008-07-16 CN CN200880101944A patent/CN101801405A/zh active Pending
Also Published As
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WO2009020744A1 (en) | 2009-02-12 |
JP2010535780A (ja) | 2010-11-25 |
JP5323832B2 (ja) | 2013-10-23 |
EP2187932A1 (en) | 2010-05-26 |
US8058237B2 (en) | 2011-11-15 |
EP2187932B1 (en) | 2015-01-28 |
US20090043078A1 (en) | 2009-02-12 |
CA2695697A1 (en) | 2009-02-12 |
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