CN101803948A - Reverse temperature control combined probe type tumor thermal-therapeutic apparatus - Google Patents
Reverse temperature control combined probe type tumor thermal-therapeutic apparatus Download PDFInfo
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Abstract
The invention provides combined probe type tumor thermal-therapeutic apparatus capable of accurately measuring and controlling temperature. The combined probe type tumor thermal-therapeutic apparatus mainly adopts a reverse temperature control inactivation tumor therapeutic method which controls and determines the heating action in the tumor according to the induced temperature on the tumor margins. The apparatus has a function of performing selective thermal damage to biological tissues, so that by using the apparatus, any length of heating time for clinical treatment of tumors of any irregular shape can be obtained, and the probability that 100 percent of tumor tissues are completely inactivated for one time, but normal tissues around the tumors are not harmed, which is an important medical aim in clinical biomedicine, is realized.
Description
One, technical field:
The present invention relates to electric heating sensing technology and technical field of automatic control.It is clinical that this programme can directly apply to tumor thermotherapy.
Two, background technology:
Tumor thermotherapy is as the tumor treatment method, proposes popularization from formal, experienced very long process.At the beginning of opening, some thermotherapy new techniques, many challenging results have been reported at clinicing aspect, but more also only to belong to the II phase clinical, from the generally accepted III phase clinical also exist certain gap (" tumor thermotherapy technology and clinical practice " Liu's .P107. an ancient woman's ornament. the thermotherapy chief of the office .2009.8 of radiotherapy section of Hunan Province tumour hospital).For example: 1, the microwave heat therapeutic technology, because of succeeding in developing of its pin type one pole microwave antenna, realized microwave energy is concentrated on needle point and needle body does not have microwave leakage, with single or many microwave antenna percutaneous punctures to the prospective tumor target area, utilize the electromagnetic energy heating of microwave can kill deep tumor, its advantage is apparent, but technically there are many insoluble problems, such as, owing to be subjected to the strong jamming of High-Power Microwave field that temperature-sensing system was lost efficacy, in fact microwave heat therapeutic has lost temp sensing function, under the situation of not controlling inner heating region temperature, the doctor can only determine the persistent period of heating by rule of thumb, and this estimation heats to treat pattern, fixedly causes over-heating to cause normal organ hot injury or underheat to cause the residual result who fails to respond to any medical treatment.In addition, this electromagnetic wave energy of microwave has wave beam and directivity characteristics, and microwave applications with current scientific and technological level, still is difficult to control the extent of injury that human body is caused in tumor thermotherapy.2, ultrasound thermal therapy technology, its advantage is radiationless to human body, does not have the roentgenotherapia sensitive question, protection is simple.But ultrasound wave is limited by self character, the organ that can not penetrate the tissue of gassiness or stopped by skeleton, thereby be not suitable for treating the pulmonary carcinoma of chest and esophageal carcinoma, intestinal cancer and the gastric cancer etc. at enteric cavity position, can not treat the hepatocarcinoma that stopped by rib.3, radio-frequency (RF) thermotherapeutic technology, also be radio-frequency ablation procedure, it is to get involved human body by the radio-frequency electrode probe, make charged particle in the probe surrounding tissue frictional heat that vibrates at a high speed, instantaneous temperature can reach 90～110 ℃, causes electrode tumor cell generation coagulation necrosis on every side, and heat production degree and current intensity and persistent period are proportionate, be negative correlation with impedance, and closely related with the water content of tissue, the speed of heating.Radio-frequency ablation technique is as the external thermotherapy new technique of introducing, China's clinical tumor tried out ten surplus year, having under expert's cooperation of enriching clinical experience, extremely indivedual successful cases appearred, advantage is visible, but the technical unavoidable problem that still has says still do not possess survey, temperature control technique from strictness.Because under the interference of the powerful field intensity of electromagnetic wave, measurement to carninomatosis kitchen range and peripheral temperature causes serious hindrance with time control, make the thermometric can't be accurate, temperature control also just can't realize, the higher-order of oscillation electromagnetic wave that this per second is tens thousand of times is unpredictable to the curative effect of tumor tissues with to the injury of peripheral normal organ tissue.From automatic control technology, belong to the open loop circuit state; From the treatment pattern, belong to pre-Value Operations, how to see fortune as for therapeutic outcome.
In addition, also have laser-induced interstitial thermotherapy technology, circulating thermal medium heating technique, magnetic induction thermotherapy technology, infrared heating technology and whole-body hyperthermia method or the like, its pluses and minuses are all respectively arranged.
Medical circle generally acknowledges that tumor cell is heated to 40～43 ℃ will begin death; And normal tissue cell is heated to and just begins death (Roemer, 1999) more than 45～47 ℃.Want to solve with temperature and kill erose whole tumor tissues and don't injure this of its peripheral normal structure difficult problem in century, the heating mode that must realize ideal just: 1, will accomplish that 100% irregular tumor tissues is heated to it and kills and wounds threshold temperature promptly more than 40～43 ℃, and keep to wipe out the needed sufficiently long time of lesion tissue; Simultaneously the temperature beyond the borderline tumor will be controlled in below 45 ℃, avoid normal structure around the tumor or organ overheated and injured (" tumor thermotherapy physics " .P4. Liu Jing. the .2008.5 of physics and chemistry institute of the Chinese Academy of Sciences).2, to accomplish to the temperature of the target tissue region that is heated carry out in real time, monitoring and the control of moment, can allow the treatment implementer " see " at any time to intravital Temperature Distribution of patient and change, improve power of a test to the treatment accuracy (" tumor thermotherapy technology and clinical practice " Liu's .P107. an ancient woman's ornament. the thermotherapy chief of the office .2009.8 of radiotherapy section of Hunan Province tumour hospital).
The thermometry of present various thermotherapy methods substantially also is in the experimentation stage, and what have does not still possess temp sensing function, from clinical practice very big distance is arranged all, the reason that causes this situation mainly be subjected to mode of heating limit (Liu Jing. the .2008 of the Chinese Academy of Sciences).In tumor thermotherapy is clinical, the temperature of destination organization is monitored in real time, be link (the woods generation .1997 in the third of the twelve Earthly Branches of the most critical of regulation and control operation process and after-action review; Li Ding nine .2003).When destination organization is heated, in the tissue temperature field especially the accurate mensuration of lesions position temperature be the successful key of operation (Liu Jing. the .2008 of the Chinese Academy of Sciences).At present, the common difficulty that existing thermotherapy method is faced is how the heat orientation to be transported to the target area tumor tissues, has both effectively killed tumor tissues and don't has injured normal structure.This key problem, do not obtain as yet so far fine solution (Liu Jing. the .2008 of the Chinese Academy of Sciences).
Obviously, when tumor was heated, if there is not measuring and controlling temp technology accurately, will have following problem to can not get solving: 1, heating intensity and the dosage to tumor tissues can't predict and determine.The clinical treatment pattern that heating can occur estimating causes two kinds of results of over-heating and underheat; 2, dare not continue long enough heat time heating time to tumor tissues, the persistent period can't be determined.If tumor tissues can not get sufficiently longly continuing the time of heating to treat, just can't realize the disposable purpose of killing tumor; 3,, can't determine the heating shape at any difform tumor.If there is not the observing and controlling temperature technique, just any difform tumor tissues 100% ground can not be forgiven in the thermal field loop line heating region more than 43 ℃, will occur easily heating and imperfectly cause residual and fail to respond to any medical treatment, or super scope, super-strength heating and the result that leads to complications; 4, Zu Zhi carbonization, gasification zone can't be determined.Do not have the observing and controlling temperature technique, just can't determine to heat carbonization, the gasification zone that whether can cause inside tumor high temperature to occur to cause, carbon, gasification bring multiple complications such as absorbing heat, constant pain can for patient's postoperative, increase patient misery or the like.
The notion of the amount of not having is unscientific.Equally,, just there is not tumor thermotherapy to the accurate measurement and time control of temperature.Up to now, all thermotherapies have to rely on doctor's individual's cognition and experience to be controlled to a great extent, and doctor's clinical experience also just often becomes a key factor of decision therapeutic effect quality.Yet, experience deviate from the result of practical situation of common occurrence in medical treatment (" tumor thermotherapy technology and clinical practice " Liu's .P107. an ancient woman's ornament. the thermotherapy chief of the office .2009.8 of radiotherapy section of Hunan Province tumour hospital).Obviously,, allow treatment implementer real-time " seeing " to intravital Temperature Distribution of patient and variation if can meet the desirable heating mode of tumor thermotherapy, most important to the power of a test that improves the treatment accuracy.
So, meet desirable heating mode, the tumor thermotherapy medical apparatus and instruments must satisfy following basic demand: 1, heat release should as far as possible only (being tumor locus) produces sufficiently high temperature in the target area, and all the other healthy positions then are in the safe temperature scope.2, any irregular tumor tissues wants 100% ground to forgive in the thermal field loop line heating region more than 43 ℃, with guarantee the tumor global tissue by integrity kill.The time of 3, can continued treatment required any length, purpose is to make the disposable deactivation of tumor as far as possible.When 4, tumor locus being heated, temperature is no more than the carbonized threshold values as far as possible, avoids the tumor tissues carbonization and causes patient's postoperative to continue the appearance of complication such as hyperpyrexia, pain.5, to the temperature of target tissue region survey, control should be easy to implement, the doctor farthest accurately held and control heats to treat process.
Three, summary of the invention:
1, the technical problem that will solve:
In order to overcome the radiation that present various tumor thermotherapy produces because of mode of heating improperly, cause the present situation that thermotherapy apparatus thermometric is inaccurate, estimate the heating bad therapeutic outcome that causes, the invention provides a kind of observing and controlling tumor micro-wound electric heating probe-type medical apparatus and instruments accurately, this brand-new thermotherapy method, can provide accurate, real-time, controlled, the constant temperature that needs to tumor, tumor cell to any difform tumor and 100% carries out disposable deactivation, does not damage the normal tissue cell that closes on simultaneously again.
2, the technical solution adopted for the present invention to solve the technical problems:
This therapeutic instrument has several thermals source, each thermal source respectively has a cover thermometric and a temperature-controlling system, cry its probe heating stylus here, probe heating stylus can be designed to thick, thin, long and short different model (as Fig. 1-1, Fig. 1-2) because of different with shape and the clinical real needs of the size of tumor.Temperature sensor, heating element heater in the probe heating stylus are connected by lead, form an one needle body with needle-like shell, handle, are connected with measure and control device through lead, constitute TT﹠C system.By measure and control device, probe heating stylus possesses heating, temperature survey, three kinds of functions of temperature adjusting simultaneously.Probe heating stylus observing and controlling precision reaches 0.1 ℃.Heating-up temperature has higher limit to set.Higher limit will be lower than the carbonization threshold values of tissue, and heating-up temperature is too high to be made carbonized, gasification and produce various post-operative complication to avoid.
Temperature detection pin (as Fig. 2) is formed an one needle body by temperature sensor, lead, needle-like shell, handle, is connected with temperature display system through lead.Temperature survey is finished by the needle point point of temperature detection pin, and the temperature display precision reaches 0.1 ℃, and the needle body external diameter is less than or equal to 2mm.Body surface under the prerequisite of non-incision, according to clinical may with demand, can get involved in inside tumor and carry out three-dimensional with outside zone that needs monitoring arbitrarily and position and deploy to ensure effective monitoring and control of illegal activities.When tumor is popped one's head in the heating stylus heating, but temperature detection pin synchro measure is to inside tumor and outside variations in temperature of having deployed to ensure effective monitoring and control of illegal activities a little, and be shown on the instrument " allow the treatment implementer ' see ' intravital Temperature Distribution of patient and change at any time, improve power of a test " to the treatment accuracy.
As Fig. 3, be the thermal field principle of heating stylus of popping one's head in separately.The situation of drawn probe heating stylus is the heating state behind the intervention when injected organism tissue among Fig. 3.After probe heating stylus gets involved human body, because the heat effect of probe heating stylus forms thermal field around probe heating stylus, and enlarge gradually, the temperature of pin is the highest, and past more temperature is low more all around, reaches low inside and high outside " sloping formula " hygral equilibrium by certain hour.Here, heating pin mark temperature determines to be heated radius length; On the contrary, if be subjected to the thermal radius end to be subjected to hot(test)-spot temperature definite, so, the radius length of being heated determines to heat the pin mark temperature again.
As Fig. 4, be the thermal field principle of the array of a plurality of probe heating styluses compositions.The heating stylus of some probes gets involved human body according to tumor and peripheral situation, weave into three-dimensional heating electrodes, each cross point in the array is a probe heating stylus pin mark position, the work of each probe heating stylus is relatively independent, probe heating stylus can be according to tumor shape editor heating electrodes shape, this array covers whole tumor, and heat is sent into tumor.
This thermal therapeutic apparatus belongs to the direct heating category, increases the density of probe heating stylus, can increase array temperature.Under the situation that array temperature remains unchanged, increase the density of probe heating stylus, can reduce required heating radius, reduce heating pin mark temperature.Fig. 4 forms 44 ℃ of thermal field loop line inside, can not surpass the temperature of probe heating stylus.Suppose that probe heating stylus is set in 45 ℃ of power supplies, according to the thermal field principle of independent probe heating stylus, the density of reasonable disposition probe heating stylus forms heat-field array.In the array inside that probe heating stylus is formed, temperature will raise in time, and the process certain hour reaches greater than 43 ℃ and is less than or equal to 45 ℃ of " sloping formula " hygral equilibriums.
Direct heating do not exist radio frequency, microwave, ultrasound wave 2 and the mutual interference of 2 above thermal source phases, the phenomenon that hot-spot causes burn appears.
As Fig. 5, be the spherical tumor thermotherapy principle of hypothesis rule.Coordinate is established the thermal field loop line that a long measure is represented 1 ℃ of interval among the figure." 1 " is the hot spot of the probe heating stylus intervention tumour centre of sphere, and " 5 " are the thermometric alarm points (which detects pin needs temperature alarming, can arbitrarily set on control instrument according to clinical demand) in the temperature detection pin intervention tumour edge normal structure.It is between 43 ℃-45 ℃ that the alarm temperature of " 5 " point is set, as Fig. 5, setting " 5 " some alarm temperature is 43.5 ℃, when to " 1 " some heat temperature raising, by the biological heat conduction principle in a period of time, heat conducts to " 5 " point, report to the police when making " 5 " point be warming up to 43.5 ℃, when " 5 " point is reported to the police, " 1 " point should stop intensification work (can pass through the automatic or manual pattern) at once, according to pop one's head in the separately thermal field principle of heating stylus of Fig. 3, through the short time adjustment, make " 5 " point stop at 43.5 ℃, what form between " 1 " and " 5 " is the centre of sphere with " 1 ", reach low inside and high outside " sloping formula " hygral equilibrium for the spherical thermal field loop line of radius between " 1 " to " 5 ".Because being subjected to the temperature of the distal point that is heated " 5 " between the thermal radius " 1 " to " 5 " determines; it is 43.5 ℃; so according to Fig. 3 thermal field principle; be subjected to the length between the thermal radius " 1 " to " 5 " to determine the final constant temperature value of " 1 " some heating to stop at about 48 ℃; like this; tumor just is controlled in greater than 43.5 ℃ and is less than or equal in low inside and high outside " sloping formula " spherical hygral equilibrium scope of 48 ℃; and the tissue beyond the tumor is controlled in less than in 44 ℃ the temperature range; this " sloping formula " hygral equilibrium is continued the long enough time (for example being no less than 60 minutes); accomplish as far as possible the disposable deactivation of 100% tumor tissues; reach thus when killing tumor tissues, protect its peripheral normal structure to avoid hot injury's ideal goal.
As Fig. 6, be the thermotherapy principle of any irregularly shaped tumor.Coordinate is established the thermal field loop line that a long measure is represented 1 ℃ of interval among the figure.Press Fig. 4 principle, shape editor's heating electrodes shape according to tumor, in Fig. 6, if set, " 4 ", " 7 " three probes heating stylus position, according to the length that is subjected to thermal radius, select heating stylus (syringe needle) thick, thin, long and short different model for use, may be the thickest, the longest as the model of " 1 ", the model of " 4 " may be the thinnest, the shortest etc.
The location basic principle of temperature detection pin alarm point is: in each self-applying thermal field of a plurality of probe heating styluses, respectively apart from this heating pin mark outer proximal most position of tumor of borderline tumor end points farthest.In Fig. 6, " 2 " are distance " 1 " borderline tumor end points farthest in " 1 " effect thermal field, locate end points " 5 " and " 8 " etc. with same principle; " 3 " are to want localized temperature alarming point, and it is positioned at the proximal most position of borderline tumor external distance " 2 ", locate temperature alarming point " 6 " and " 9 " etc. with same principle.Wherein end points " 2 ", " 5 " and " 8 " etc. are on the edge line of tumor, and alarm point " 3 ", " 6 " and " 9 " etc. are respectively in the good tissue outside the nearest borderline tumor of end points " 2 ", " 5 " and " 8 ".
" 3 " among Fig. 6, " 6 ", " 9 " are respectively the thermometric alarm points of corresponding " 1 ", " 4 ", " 7 ", and alarm temperature all is located at 43.5 ℃.According to Fig. 3, Fig. 4, Fig. 5 principle, through certain hour, " 1 ", " 4 ", " 7 " three heating-up temperatures should rest on 51 ℃ respectively, 45.5 ℃, about 47 ℃, form between " 1 " and " 3 " greater than 43.5 ℃ and be less than or equal to 51 ℃, between " 4 " and " 6 " greater than 43.5 ℃ and be less than or equal to 45.5 ℃, between " 7 " and " 9 " greater than 43.5 ℃ and be less than or equal to three groups of " sloping formula " spherical temperature of thermal field balances of 47 ℃, and in tumor periphery " 3 ", " 6 ", " 9 " 3 connecting lines (Fig. 6 the 11st) that form 43 ℃ of thermal field loop lines in addition are fully enclosed in tumor integral body in 43 ℃ of thermal field loop lines.With 43 ℃ of thermal field loop lines is the boundary, and past more inside tumor temperature is high more, and tumor is controlled in fully to be killed in the temperature; And past more outside temperature is low more, and normal structure is in safe temperature; Dash area is the normal structure of tumor periphery, and temperature is to be between 43 ℃-45 ℃ substantially, and it is that tumor tissues is subjected to hot injury's (more than 40-43 ℃) and normal structure is not subjected to the turnover critical region of hot injury's (45 ℃ below-47 ℃).
Here, under the prerequisite beyond the position of 43.5 ℃ of temperature alarming points " 3 ", " 6 ", " 9 " and 43 ℃ of thermal field loop lines are positioned in the borderline tumor line in the good tissue of minimum distance, the density of probe heating stylus is big more, the shape of heating electrodes is just more near tumor shape, the dash area volume is just more little, its temperature is just more near 43 ℃, simultaneously, be subjected to thermal radius also just more little between every group of pin, the heating-up temperature of probe heating stylus is just low more, cause the probability of carbonized, gasification just more little, the generation probability of post-operative complication is just more little.Therefore, in actual clinical, according to the concrete shape of tumor, science is arranged the thermal treatment zone and test point, and the shape of rationally editing heating electrodes is very important.
3, beneficial effect of the present invention:
1. the method is closed under the normal structure prerequisite not injuring, and can continue long arbitrarily heat time heating time to tumor is whole, with the disposable deactivation of tumor.
2. the method can realize that 100% tumor tissues to the arbitrary shape tumor carries out intactly, do not have with omitting and heats to treat.
3. the method can realize precisely three-dimensional in real time monitoring in tumor therapeutic procedure, helps regulating and control operation process and after-action review.
4. the method can make tumor no carbonization point in being subjected to thermal process produce, thereby avoids the postoperative multiple complications to produce, and helps tumor patient and regains one's strength rapidly.
5. the method can avoid some limbs of patient and organ cut because of suffering from tumor, and recovers its normal function rapidly and keep attractive in appearance.As osteosarcoma, breast carcinoma etc.
6. the method absorption of human body by heat-inactivated neoplastic process in, patient self produces antineoplastic antibody-" solidify and drive Seedling ", helps killing at the free tumor cell in the whole body, and suppresses the transfer of tumor; Metastasis is inactivated with main focus and spontaneous regression plays irreplaceable positive role.
Four, description of drawings:
Fig. 1-1: be thin short probe heating stylus structure chart: 1, needle body; 2, temperature sensor; 3, heater; 4, hands handle; 5, lead.
Fig. 1-2: be thick long probe heating stylus structure chart: 1, needle body; 2, temperature sensor; 3, heater; 4, hands handle; 5, lead.
Fig. 2: be temperature detection needle construction figure: 1, needle body; 2, temperature sensor; 3, hands handle; 4, lead;
Fig. 3: be the thermal field schematic diagram of heating stylus of popping one's head in separately: 1, probe heating stylus and 45 ℃ of thermal field loop lines; 2,44 ℃ of thermal field loop lines; 3,43 ℃ of thermal field loop lines.
Fig. 4: be the array thermal field schematic diagram that a plurality of probe heating styluses are formed: 1, probe heating stylus and 45 ℃ of thermal field loop lines; 2,44 ℃ of thermal field loop lines; 3,43 ℃ of thermal field loop lines.
Fig. 5: the spherical tumor thermotherapy schematic diagram of analog rule: 1, probe heating stylus and 48 ℃ of thermal field loop lines; 2,46 ℃ of thermal field loop lines; 3,44 ℃ of thermal field loop lines and spheroid borderline tumor line; 4,43 ℃ of thermal field loop lines; 5, temperature detection pin and 43.5 ℃ of temperature alarming points.
Fig. 6: simulate any irregularly shaped tumor thermotherapy schematic diagram: 1, probe heating stylus and 51 ℃ of thermal field loop lines; 2, distance " 1 " tumor tissues end points farthest in heating stylus " 1 " the effect thermal field; 3, borderline tumor is with external distance end points " 2 " nearest temperature detection pin mark and 43.5 ℃ of temperature alarming points; 4, probe heating stylus and 45.5 ℃ of thermal field loop lines; 5, distance " 4 " tumor tissues end points farthest in heating stylus " 4 " the effect thermal field; 6, borderline tumor is with external distance end points " 5 " nearest temperature detection pin mark and 43.5 ℃ of temperature alarming points; 7, probe heating stylus and 47 ℃ of thermal field loop lines; 8, distance " 7 " tumor tissues end points farthest in heating stylus " 7 " the effect thermal field; 9, borderline tumor is with external distance end points " 8 " nearest temperature detection pin mark and 43.5 ℃ of temperature alarming points; 10, any erose tumor tissues simulation drawing; 11,43 ℃ of thermal field loop lines; 12, dash area is more than or equal to 43 ℃ and less than the normal structure of 45 ℃ tumor periphery.
Five, the specific embodiment:
The probe heating stylus of each road all works alone, independently-powered.Power supply is a voltage stabilization and current stabilization dc source independently.Supply voltage may be selected in 36V with interior safety range.
In order to reduce diameter of wire, reduce electric current as far as possible, the power supply current limliting is limit at 200mA, and when temperature was heated to 45 ℃, balanced balanced current can not surpass 100mA.Power is no more than 7.2W.
When probe heating stylus power supply, heater begins to heat up, and is initially at 36.5 ℃ of human body temperature, and voltage is lower than 36V, saturation current 200mA.When temperature is raised to 45 ℃, the corresponding resistance of the temperature sensor in the probe heating stylus, resistance value is at this moment represented 45 ℃, and system enters the current stabilization state, and electric current will be lower than 200mA, and temperature will keep 45 ℃.
If voltage 30V, electric current 0.2A, power satisfies 6W, and critesistor equals 150 Ω, satisfies critesistor resistance and temperature relation 150 Ω/45 ℃ simultaneously, and at this moment, critesistor resistance and temperature coefficient are 150 Ω/45 ℃.
Claims (7)
1. this therapeutic instrument survey, temperature control be the heating stylus of electric heating probe accurately, in the needle-like shell, temperature sensor, heater, lead are linked in sequence, there is handle the outer rear end of shell, it is characterized in that: when giving probe heating stylus power supply heating, probe heating stylus has the characteristic that does not produce any electronic interferences, utilize the coefficient of relationship of critesistor resistance and probe temperature, accurately measure the real time temperature of heated probe, and, make the temperature of probe can adjust its intensification at any time, lower the temperature or rest on a certain temperature value by the clinical treatment demand by automaton.The heating stylus of this probe has the unique function that heating, thermometric, temperature control three functions combine in a pin.The observing and controlling precision reaches 0.1 ℃.
2. the thermometric work of this therapeutic instrument temperature detection pin can be carried out synchronously with the work of heating of probe heating stylus, do not produce any electronic interferences electromagenetic wave radiation during because of probe heating stylus heating, therefore simultaneously, in heating the temperature detection needle set have can be incessantly, accurately, real-time thermometric function.Temperature measurement accuracy reaches 0.1 ℃.
3. this therapeutic instrument can be at any erose tumor editor and the akin heating electrodes of its shape, and tumor is covered function exhaustively fully.
4. this therapeutic instrument can continue the required arbitrarily long function of the disposable deactivation tumor of clinical thermotherapy after the tumor global tissue reaches the heating-up temperature balance.
5. this therapeutic instrument can be to biological tissue's function of hot injury selectively, thereby realizes only the tumor tissues hot injury not being had tumor periphery normal structure hot injury's a tumor thermotherapy medical science target.
6. this therapeutic instrument has the characteristic of different carbonization threshold values at the different tissues growing tumors, and heating stylus can be provided with the function of different heating ceiling temperature values to probe, avoids carbonized in the art, and postoperative is avoided various complication.
7. this utilization borderline tumor of this therapeutic instrument temperature sensor that is heated is controlled and is determined inside tumor to add the method and the function of the reverse temperature control treatment tumor of thermal behavior and heating-up temperature.
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| CN114886553A (en) * | 2022-05-23 | 2022-08-12 | 南京诺源医疗器械有限公司 | Temperature control method and device, electronic equipment and storage medium |
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