CN101878008A - 带有用于具体心门、隆线及侧分支治疗之药阱的分叉支架 - Google Patents

带有用于具体心门、隆线及侧分支治疗之药阱的分叉支架 Download PDF

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CN101878008A
CN101878008A CN200880118602XA CN200880118602A CN101878008A CN 101878008 A CN101878008 A CN 101878008A CN 200880118602X A CN200880118602X A CN 200880118602XA CN 200880118602 A CN200880118602 A CN 200880118602A CN 101878008 A CN101878008 A CN 101878008A
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丹尼尔·格雷格里奇
迈克尔·P·迈耶
大卫·L·弗里森
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Boston Scientific Scimed Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/856—Single tubular stent with a side portal passage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541—Adjacent bands are arranged out of phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir

Abstract

本发明涉及支架，所述支架从不同的支架区域传送多种治疗方式。

Description

带有用于具体心门、隆线及侧分支治疗之药阱的分叉支架
技术领域
一些实施例中，本发明涉及可植入的医疗器械、其制造以及使用方法。一些实施例涉及传送系统，诸如在传送这些器械时使用的所有类型的导管。
背景技术
支架是导入到体腔中的医疗器械，并为本领域人员所熟知。通常，支架通过所谓的“微创技术(minimally invasive techniques)”植入到血管中腔内狭窄处或动脉瘤处，在该微创技术中，径向收缩形态(可选为通过鞘和/或导管限制成径向压缩形态)的支架被支架传送系统或“导入器”传送到所需部位。该导入器可从体外的出入口位置(例如通过患者的皮肤)进入患者体内或者通过“切除(cut down)”技术进入患者体内，该技术中，进入血管通过较小的外科装置而被暴露出来。
支架、移植物、支架—移植物、腔静脉过滤器、可扩张框架以及类似的可植入医疗器械(在下文中统称为支架)是径向可扩张的内支架(endoprosthese)，它们为通常能够穿过腔壁(transluminally)被植入并在经皮导入之后径向扩大的血管内植入物。支架可被植入到各种体腔或脉管中，诸如脉管系统、泌尿系统、胆管、输卵管、冠状血管、二级脉管等。支架可以是自扩张的、通过诸如当安装在充气球囊时的内部径向力扩张、或者是自扩张和充气球囊扩张的组合(混合扩张)。
可以制造出支架的方法包括由管状原料切削或蚀刻出设计图样，由平面片材经切削或蚀刻然后将其卷起，或者由一种或多种交织的金属丝或编织带制成。
在脉管系统中，在脉管的分叉处形成狭窄部是很常见的。分叉处是脉管系统或者身体其他部位中第一(或主)脉管分叉成两条或两条以上支脉管的区域。在这一分叉处发生狭窄损伤或损伤，该损伤可以只是影响这些脉管中的一条(即支脉管中的任一条或者是主脉管)，这些脉管中的两条，或者是全部三条脉管。由此，可根据狭窄部相对于分叉处的位置而对分叉处的狭窄部进行分类，如ICPS斑分布分类(ICPS Plaque Distribution Classification)和杜克斑分布分类(Duke plaque distribution classification)。然而，需要运用支架是在与动脉或静脉分叉处(例如，哺乳动物大动脉进入髂总动脉的分叉处)并排设置的或延伸穿过该分叉的部位时，许多现有技术的支架不能完全满足使用要求。
上述引用的及/或说明的技术无意构成承认任何专利、公开或本文中引用的其他信息是相对于本发明的“现有技术”。另外，这一部分不应被解释成已经做过检索或者不存在37C.F.R.§1.56(a)所定义的相关信息的含义。
在本申请中任何地方提到的所有美国专利以及申请和所有的公开文件，通过引证将它们整体合并在此。
不作为对发明范围的限制，本发明的某些要求保护的实施例的简要概述说明如下。所概述的本发明实施例的详细说明及/或本发明的补充实施例可以在下面的发明的具体实施方式中找到。
发明内容
至少一实施例中，本发明涉及从不同的支架区域排出不同体积的至少一种治疗剂。至少一个实施例中，支架的一个区域所排出治疗剂的浓度，不同于支架的至少另一区域所排出治疗剂的浓度。至少一实施例中，支架的一个区域排出治疗剂的排出速率不同于支架的至少另一区域排出治疗剂的排出速率。
这些和其它体现了本发明的特征的实施例，指出了文后所附权利要求书中的特性，并构成了本文的一部分。然而，为了进一步理解本发明、通过其使用而得到的其优点和目的，可参考构成本文另一部分的附图以及所附的描述性内容，其中阐示和描述了本发明的实施例。
附图说明
下文通过参考附图对本发明作了详细说明。
图1为包括多个部件的支架的立体图；
图2为图1所示多个部件中一个部件的放大图；
图3为包括多个部件和涂覆物保持件的分叉支架的平面图；
图4为带有排出不同体积治疗剂之区域的分叉支架的平面图；
图5为带有排出不同体积治疗剂之区域的另一分叉支架的平面图；
图6为带有排出不同体积治疗剂之区域的另一分叉支架的平面图；
图7为处于扩张状态的分叉支架的侧视图，其中侧分支与支架主体成斜角。
具体实施方式
尽管本发明可以许多不同形式来实施，但在此描述的为特定的较佳实施例。这一描述是本发明原理的范例，而并无意将本发明限制于所阐述的特定实施例。
为了揭示，图中相同的附图标记指向相同的特征，除非另有说明。
图1和3示出了包括多个部件14的支架10，所述部件14形成绕支架10的圆周延伸的周面环11。图1所示的支架10为非分叉支架10的形态的一个例子，图3所示的支架10为分叉支架10的形态的一个例子。图1和3所示的支架10的形态表示用于传送治疗方式的支架10形态的非限制性例子，其包括在本发明的任何可用的支架10形态的范围之内。
本申请所使用的部件14包括柱杆13和接头12。至少一个实施例中，柱杆13的沿其长度方向的宽度和厚度都基本相同。一些实施例中，柱杆13的沿其长度方向的厚度基本相同。另一些实施例中，柱杆13的沿其长度方向的宽度基本相同。至少一个实施例中，接头12的沿其长度方向的宽度和厚度都基本相同。一些实施例中，接头12的沿其长度方向的宽度基本相同。另一些实施例中，接头12的沿其长度方向的厚度基本相同。
部件14的宽度为部件14的一条圆周侧边与另一条圆周侧边之间的距离。部件14的厚度为部件14的内腔表面与外腔表面之间的距离。部件14的直线长度为部件14的近端与远端之间的距离。部件14的非直线长度为部件14的近端到远端的路径长度。
一些部件14具有至少一个直部16和至少一个回转部18，如图2所示。部件14的直部16的宽度可与所述至少一个回转部18的宽度相同，如图1所示，或者直部16可比所述至少一个回转部18宽，如图3所示。各部件14具有四条供治疗剂排出的侧边：外腔侧边(部件14的靠近内腔壁的侧边)、内腔侧边(部件14的靠近内腔的侧边)、以及部件14的与所述外腔侧边和内腔侧边成斜角的其他两条侧边。如本申请所使用的，斜角系指0～180度之间的任何角度，包括90度。各部件14具有长度(L1)、宽度(W1)及深度(图2未示)。
支架10具有不同的区域及/或子区域。作为一个非限制性的例子，图1所示的支架10可分为近侧区2、中间区4、及远侧区6，各所述区具有两个由部件14形成的周面环11。本技术领域的普通技术应认识到，可有多种方法将图1所示的支架10设计为尺寸不同且沿支架10的长度方向设置的不同区域及/或子区域。由此，在本发明的范围之内，支架10可具有一个、两个、三个、四个、五个、六个、七个、八个、九个、十个、十一个、十二个、十三个、十四个、十五个、十六个、十七个、十八个、十九个、二十个或以上的区域。
类似地，分叉支架10也有若干区域。例如，这些区域包括近侧主分支区80a、中间区82、及远侧主分支区80b，如图3所示。近侧主分支区80a和远侧主分支区80b各自包括至少一个周面环11。中间区82包括侧分支84和对侧区86。对侧区86的周面环11b从侧分支84的第一侧边92绕支架10的周面延伸至侧分支84的第二侧边94。侧分支84具有至少一个侧分支部件14和用于界定可扩张分支84之开口的周界部88。侧分支84的部件14为支架10的侧分支84区域的子区域的一个非限制性例子。周界部88可为任何形状，包括但不限于，椭圆形，圆形，或矩形。周界部88可为与支架10的其他部件14所分离的独立部件14，或者周界部88可由支架10的一些部件14所形成。
至少一个实施例中，本发明涉及这样一种支架10，即多种治疗方式从所述支架10的不同区域及/或子区域排出。为了传送多种治疗方式，支架10可具有设计用于传送至少一种治疗剂的任何机构，包括现有技术中用于传送治疗剂的装置、涂覆物保持件22、或它们的任何组合。第11/857736号、名称为“允许药物延长释放及/或聚合物与OD表面增强粘合的支架设计(Stent DesignAllowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to ODSurface)”的专利申请中详细描述了不同种类的涂覆物保持件22，其内容通过引用的方式完整合并在此。应注意，涂覆物保持件22可有不同的形态而使相同体积的治疗剂排出，或者具有相同形态，而所述相同形态具有使得不同体积治疗剂排出的不同尺寸。简明起见，本申请所使用的涂覆物保持件22系指任何设计为对至少一种治疗剂进行传送的机构，所述机构(部分或完全)形成在支架10的部件14的本体内部，或者与支架10的部件14的本体接合的。涂覆物保持件22位于包括支架10的不同区域及/或子区域的部件14的至少一条侧边上。
由于压差可改变治疗剂的反应度，因此压差是对支架10进行配置而从不同区域传送治疗方式的一个原因。由此，适当地改变支架10的不同区域中治疗剂的相对类型、浓度、体积或排出速率是有益处的。例如，对于分叉支架10，主分支区80与侧分支区84具有不同的类型、浓度、体积或排出速率是有益处的，下文将详述这一点。使用可传送多种治疗方式的支架10的另一个原因是为了将治疗定位至支架10与体腔需要治疗之位置接触的区域。例如，支架10可设计为仅支架10的与狭窄处接触的区域会传送/排出治疗剂以治疗所述狭窄处。
至少一实施例中，支架10的至少一个区域传送与支架10的至少另一区域不同的治疗方式。由此，单个支架10传送至少两种治疗方式。至少一实施例中，支架10的各区域传送不同的治疗方式。不同的治疗方式包括但不限于不同的治疗剂、不同的治疗剂浓度、不同的治疗剂局部浓度、不同的治疗剂体积、不同的治疗剂排出速率/不同的治疗剂释放持续时间、不同的治疗剂释放动力学，及它们的任何组合。可单独使用不同的治疗方式，或者与支架10的一或多个不同区域组合使用。
影响排出速率/释放持续时间的不同途径包括但不限于，在一些涂覆物保持件22中包括非活性材料、改变一些涂覆物保持件22中的治疗剂的配方、在沉淀在一些涂覆物保持件22中的治疗剂的上方形成阻碍层，或它们的任何组合。一些实施例中，所述涂覆物保持件22中的非活性材料增加治疗剂的表面面积/体积比，藉此影响治疗剂的释放持续时间。改变治疗剂的配发包括但不限于，改变治疗剂的比例、改变治疗剂的种类、改变治疗剂的装载。至少一个实施例中，治疗剂上方的阻碍层减缓治疗剂的释放，藉此延长治疗剂的释放持续时间。第11/857736号、名称为“允许药物延长释放及/或聚合物与OD表面增强粘合的支架设计(Stent Design Allowing Extended Release of Drug and/or EnhancedAdhesion of Polymer to OD Surface)”的共同受让申请案描述了阻碍层的使用。
不同的释放动力学包括短时程释放速率、长时程释放速率、治疗剂的局部浓度和效果持续时间。可通过药物/载体比、表面面积、治疗剂的总体积、及血管中治疗剂的宏观分布来调节释放率。
现参考图3所示的可用于分叉处的支架10来详细描述不同的治疗方式。然而，如前所述，可形成支架10的任何形态来传送至少两种治疗方式。此外，图3～7所示的实施例示出了应用于支架10的一条侧边(例如，外腔侧边)的本发明。如前所述，使用支架10的两条侧边来传送多种治疗方式也在本发明的范围之内。简明起见，图3～7中的支架10都具有相同种类的涂覆物保持件22，而如前所述，支架10的不同区域及/或子区域具有不同的涂覆物保持件22也在本发明的范围之内。
至少一个实施例中，支架10从支架10的不同区域传送不同体积的治疗剂。由于支架10的不同区域的涂覆物保持件22中/其上所沉积之治疗剂的体积不同、支架10的各区域中的涂覆物保持件22的种类不同、涂覆物保持件22的尺寸不同、支架10的各区域中的涂覆物保持件22的数量不同，或它们的任何组合，因此可通过支架10的不同区域来传送不同体积的治疗剂。
至少一实施例中，支架10的不同区域的涂覆物保持件22中/其上沉积有不同体积的治疗剂。一实施例中，支架10上的所有涂覆物保持件22的尺寸/体积相同，并且支架10的各区域的涂覆物保持件22的数量相同，并且支架10的不同区域上施加有不同体积的治疗剂。这一实施例中，所有涂覆物保持件22的尺寸设为使得有最大体积的治疗剂沉积在支架10上，并且涂覆物保持件22之中/其上具有最大体积的治疗剂而一些涂覆物保持件22之中/其上具有较小体积的治疗剂以使其为“未完全填充”治疗剂。这一实施例中，由于仅需要一种类型和尺寸的涂覆物保持件22，因此支架10的制造得以简化。应注意，这一支架10的实施例也可从支架10的不同区域排出相同体积的治疗剂，例如，当向整个支架10施加相同体积的治疗剂时。
至少一个实施例中，支架10的不同区域使用尺寸不同的涂覆物保持件22。如前所述，涂覆物保持件22的体积/尺寸取决于涂覆物保持件22的长度、宽度、及深度，并且长度、宽度、及深度中的至少一个的变化会影响可沉积在涂覆物保持件22之上/其中的治疗剂的体积，并且随之影响从涂覆物保持件22排出的治疗剂的体积、及/或局部浓度。至少一实施例中，涂覆物保持件22为孔，并且所述孔的直径影响治疗剂的局部浓度。由此，举例来说，若涂覆物保持件22为孔的形式，增大涂覆物保持件22的直径则增大治疗剂的局部浓度，减小涂覆物保持件22的直径则减小治疗剂的局部浓度。一实施例中，所述局部浓度受微米级变化的影响。
为了保证不同体积的治疗剂从支架10的不同区域排出，沉积在支架10的某个区域上的治疗剂的体积至少应等于该区域上所有涂覆物保持件22的总体积，以使各涂覆物保持件22含有最大量的治疗剂。应注意，如在第11/857736号、名称为“允许药物延长释放及/或聚合物与OD表面增强粘合的支架设计(Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion ofPolymer to OD Surface)”的专利申请中所详细描述地，治疗剂的体积决定治疗剂从支架10排出的时间长度，即，释放时间。由此，其上/其中沉淀有大体积治疗剂的涂覆物保持件22排出治疗剂的时间长于其上/其中沉淀有较小体积治疗剂的涂覆物保持件22。
至少一实施例中，支架10的至少一个区域的涂覆物保持件22数量不同于支架10的其他区域。影响支架10的区域中的涂覆物保持件22数量的多个因素包括但不限于，支架10的区域中的涂覆物保持件22的密度、形成支架10的所述区域的部件14的数量、支架10的区域的各部件14上的涂覆物保持件22的数量，及它们的任何组合。
至少一实施例中，支架10的至少一个区域具有不同的涂覆物保持件22密度。涂覆物保持件22的密度由每单位面积的涂覆物保持件22数量决定。至少一实施例中，涂覆物保持件22的密度影响治疗剂的局部浓度。由此，当涂覆物保持件22之间的间隔增大时，即涂覆物保持件22的密度小时，治疗剂的局部浓度下降，并且当涂覆物保持件22之间的间隔减小时，即涂覆物保持件22的密度大时，治疗剂的局部浓度增大。一实施例中，治疗剂局部浓度受毫米级变化的影响。图4中，例如，对侧区86的部件的涂覆物保持件22密度大于近侧主分支区80a的涂覆物保持件22密度。这一实施例中，若支架10的两个区域的部件14的数量相同，但部件14的涂覆物保持件22密度不同，则支架10的这两个区域具有不同数量的涂覆物保持件22。
至少一实施例中，支架10的不同区域的涂覆物保持件22密度不同，且涂覆物保持件22的尺寸不同。例如，满足如下条件会发生这样的情形，即，若具有高密度涂覆物保持件22的部件14的深度(厚度)没有大到足以调整涂覆物保持件22的尺寸，这样所述部件的尺寸与低密度涂覆物保持件22的部件14的尺寸相同，而不会影响部件14的完整性。
至少一实施例中，支架10的不同区域的涂覆物保持件22密度不同，而涂覆物保持件22的尺寸相同。例如，满足如下条件会发生这样的情形，即，若所述部件14的深度足够大，以使位于所述部件14中的高密度涂覆物保持件22的深度大于位于所述部件14内的低密度涂覆物保持件22的深度。这一实施例中，高密度涂覆物保持件22的较大的深度使得高密度涂覆物保持件22排出治疗剂的时间长于低密度涂覆物保持件22排出治疗剂的时间，即使是在由低密度涂覆物保持件22和高密度涂覆物保持件22这两者来排出相同总量的治疗剂的情况下，也是如此。
至少一实施例中，图中未示，不同数量的部件14构成支架10的至少一个区域，而各部件14具有相同数量的涂覆物保持件22。应注意，只要支架10的各部件14具有相同数量的涂覆物保持件22，支架10的所述各区域中的涂覆物保持件22密度可相同或不同。一实施例中，支架10的不同区域具有不同数量的周面环11，而各周面环11包括相同数量的部件14。由此，若近侧主分支区80a具有四个各自包括十个部件14的周面环11，远侧主分支区80b具有三个各自包括十个部件14的周面环11，则近侧主分支区80a包括的涂覆物保持件22的数量大于远侧主分支区80b包括的数量。
一实施例中，支架10的不同区域具有相同数量的周面环11，但支架10的一个区域具有至少一个带有不同数量部件14的周面环11。由此，在近侧主分支区80a和远侧主分支区80b具有三个周面环11，但近侧主分支区80a的一个周面环11所具有的部件14的数量多于构成其他周面环11的部件14的数量的情况下，近侧主分支区80a具有较多数量的部件14。
一实施例中，支架10的至少一个区域具有不同数量的涂覆物保持件22，这是因为其具有不同于支架10的另一区域的不同数量的部件14和不同密度的涂覆物保持件22。例如，支架10的带有较多数量部件14和较高密度涂覆物保持件22的区域比支架10的带有较少数量部件14和较低密度涂覆物保持件22的区域具有更多的涂覆物保持件22。应注意，较之第二区域具有较高密度涂覆物保持件22及较少部件14的第一区域可设计为具有与所述第二区域一样数量的涂覆物保持件22。
至少一实施例中，支架10的不同区域在该区域的各部件14上具有不同数量的涂覆物保持件22。一实施例中，支架10的不同区域中的涂覆物保持件22密度相同，但支架10的各个区域中的涂覆物保持件22的总数量可为不同。一实施例中，支架10的不同区域具有不同长度的部件14。一实施例中，支架10的一个区域的不同部件14具有不同长度，其中部件14具有不同数量的涂覆物保持件22，但具有相同密度的涂覆物保持件22，如下文将参考图7所描述。
图3～7示出了许多上述设计实施例。如下文所描述之非限制性例子所描述的，可有多者形态和设计来作为本发明实施例的例子。图3中的支架10具有侧分支84，其中多个部件14各具有三个涂覆物保持件22，且正方形的周界部88具有七十六(76)个涂覆物保持件22。对侧区86具有总共四十八(48)个涂覆物保持件22。应注意，侧分支84中的部件14的长度小于对侧区86中的部件14的长度，但这两个区域中的涂覆物保持件22的密度相同。近侧主分支区80a和远侧主分支区80b分别具有总共一百四十四(144)个涂覆物保持件22。应注意，尽管近侧主分支区80a、对侧区86、及远侧主分支区80b的部件14分别具有四个涂覆物保持件22，若所有涂覆物保持件22的尺寸相同，对侧区86排出的治疗剂的总体积小于近侧主分支区80a或者远侧主分支区80b。还应注意，若涂覆物保持件22的尺寸相同并且其中/其上沉积有相同量的治疗剂，近侧主分支区80a、远侧主分支区80b、对侧区86、及侧分支84的部件14各自排出治疗剂所用的时间量相同。
图4中，侧分支84的各部件14具有六个涂覆物保持件22，对侧区86的各部件14具有八个涂覆物保持件22，近侧主分支区80a及远侧主分支区80b的各部件14具有四个涂覆物保持件22。这一实施例中的周界部88具有一百二十(120)个涂覆物保持件22。这一实施例中，近侧主分支区80a的部件14和对侧区82的部件14的长度相同，但远侧部80的涂覆物保持件22密度是对侧区82的涂覆物保持件22密度的一半。近侧主分支区80a及远侧主分支区80b分别具有总共一百四十四(144)个涂覆物保持件22，而对侧区86具有总共一百九十二(192)个涂覆物保持件22。由此，本实施例中，若所有的涂覆物保持件22的尺寸相同，则对侧区86所排出的治疗剂的总体积大于近侧主分支区80a或远侧主分支区80b。若对侧区86的涂覆物保持件22小于近侧主分支区80a和远侧主分支区80b的涂覆物保持件22，则近侧主分支区80a和远侧主分支区80b排出治疗剂的时间长于对侧区86。
图5中，侧分支84的各部件14具有三个涂覆物保持件22，对侧区86的各部件14具有四个涂覆物保持件22，近侧主分支区80a和远侧主分支区80b的各部件14具有八个涂覆物保持件22，周界部88具有六十(60)个涂覆物保持件22。这一实施例中，近侧主分支区80a和远侧主分支区80b的涂覆物保持件22密度大于对侧区86和侧分支84，并且对侧区86的涂覆物保持件22密度大于侧分支84。由此，支架10包括三个具有不同涂覆物保持件22密度的区域。近侧主分支区80a和远侧主分支区80b分别具有总共两百八十八(288)个涂覆物保持件22，而对侧区86具有总共九十六(96)个涂覆物保持件22。由此，这一实施例中，若所有的涂覆物保持件22的尺寸相同，则近侧主分支区80a和远侧主分支区80b各自排出的治疗剂体积大于对侧区86所排出的治疗剂体积，这与图4所示的支架10相反。若对侧区86的涂覆物保持件22大于近侧主分支区80a和远侧主分支区80b的涂覆物保持件22，则近侧主分支区80a和远侧主分支区80b排出治疗剂的时间短于对侧区86。
图6所示的形态与图5基本相同，其不同之处在于侧分支84的各部件14具有六个涂覆物保持件22，而不是图5所示的三个。由于部件14的长度基本相同，形成图6之侧分支84的部件14的涂覆物保持件22密度大于图5中侧分支84的部件14。此外，图5中侧分支84的部件14的涂覆物保持件22大于图6中侧分支84的部件14的涂覆物保持件22。因此，图5的侧分支84排出治疗剂的时间长于图6的侧分支84。
图7中，尽管部件14a和14b各自的涂覆物保持件22密度相同，但由于部件14a和14b的长度不同，侧分支84的部件14a和14b分别具有不同数量的涂覆物保持件22(部件14a上有七个涂覆物保持件22，部件14b上有三个涂覆物保持件22)。这一实施例中，部件14a排出的治疗剂的总体积大于部件14b，但如果涂覆物保持件22的尺寸相同，部件14a和14b排出治疗剂的时间长度相同。
这一实施例中，处于扩张状态的侧分支84与支架10的主分支80成斜角。应注意，侧分支84与近侧主分支区80a所成的远侧角(β)小于侧分支84与远侧主分支区80b所成的近侧角(α)。所述角度的锐度与侧分支84的最靠近该锐角的一或多个部件14b上的应力有相关性。由于这一应力，侧分支84的所述多个一或多个部件14b上的相同尺寸涂覆物保持件22的最大可能数量小于侧分支84的最靠近不那么锐利的角(α)的一或多个部件14a上的相同尺寸涂覆物保持件22的最大可能数量。这一应力还会影响部件14上的涂覆物保持件22的长度、宽度、及深度，以及部件14上的涂覆物保持件22之间的距离。由于周界部88与侧分支84的所述一或多个部件14接合，其亦承受能够影响位于周界部88上的涂覆物保持件22的数量和尺寸的应力。
还应注意，本实施例中，侧分支84的涂覆物保持件部件14具有不同的长度，近侧部件14a的长度大于远侧部件14b。这一设计允许侧分支84的部件14在侧分支84与支架10的主分支80成斜角时延伸统一的距离而进入边支血管。侧分支84的具有相同长度的部件14也在本发明的范围之内。
下列编号的陈述对至少一个实施例的特征进行了描述：
1.一种支架，所述支架具有包括多个部件的本体，所述多个部件限定所述支架的本体，所述本体包括：
第一区域，所述第一区域包括第一多个第一涂覆物保持件，各所述第一多个第一涂覆物保持件具有第一体积和第一体积的治疗剂，所述第一多个第一涂覆物保持件排出第一总体积的第一治疗剂；及
第二区域，所述第二区域包括第二多个第二涂覆物保持件，所述第二多个第二涂覆物保持件具有第二体积和第二体积的第二治疗剂，所述第二多个第二涂覆物保持件排出第二总体积的第二治疗剂；
其中各所述第一多个第一涂覆物保持件的所述第一体积等于各所述第二多个第二涂覆物保持件的所述第二体积，所述第一治疗剂的第一体积大于所述第二治疗剂的第二体积，并且所述第一治疗剂的第一总体积大于所述第二治疗剂的第总二体积。
2.如1所述的支架，所述第一治疗剂不同于所述第二治疗剂。
3.如1所述的支架，各所述多个部件具有宽度和长度，所述宽度沿所述部件的长度基本保持不变。
4.如1所述的支架，各所述多个部件具有厚度和长度，所述厚度沿所述部件的长度基本保持不变。
下列编号的陈述对至少一个实施例的特征进行了描述：
1.一种支架，所述支架具有包括多个部件的本体，所述多个部件限定所述支架的本体，所述本体包括：
第一区域，所述第一区域具有多个第一涂覆物保持件，所述多个第一涂覆物保持件具有第一形态，第一治疗剂以第一排出速率从所述多个第一涂覆物保持件排出；及
第二区域，所述第二区域具有多个第二涂覆物保持件，所述多个第二涂覆物保持件具有第二形态，第二治疗剂以第二排出速率从所述多个第二涂覆物保持件排出；
其中所述第一排出速率大于所述第二排出速率，并且所述第一涂覆物保持件的第一形态不同于所述第二涂覆物保持件的第二形态。
2.如1所述的支架，所述第一治疗剂具有第一浓度，所述第二治疗剂具有第二浓度，所述第一浓度等于所述第二浓度。
3.如1所述的支架，所述第一治疗剂具有第一浓度，所述第二治疗剂具有第二浓度，所述第一浓度大于所述第二浓度。
4.如1所述的支架，所述第一区域排出第一总体积的治疗剂，所述第二治疗剂排出第二总体积的治疗剂，所述第一总体积等于所述第二总体积。
5.如1所述的支架，所述第一区域排出第一总体积的治疗剂，所述第二治疗剂排出第二总体积的治疗剂，所述第一总体积大于所述第二总体积。
6.如5所述的支架，所述第一涂覆物保持件的第一形态具有第一体积，所述第二涂覆物保持件的第二形态具有第二体积，所述第一体积等于所述第二体积，所述第一区域的部件具有第一密度的第一涂覆物保持件，所述第二区域的部件具有第二密度的第二涂覆物保持件，所述第一密度大于所述第二密度。
7.如1所述的支架，所述多个第一涂覆物保持件的至少一部分形成在包括所述支架第一区域的多个所述部件的所述本体之内。
8.如7所述的支架，所述多个第二涂覆物保持件的至少一部分形成在包括所述支架第二区域的所述多个部件的所述本体之内。
9.如1所述的支架，其中所述第一区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合。
10.如9所述的支架，其中所述第二区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合，所述第二区域不同于所述第一区域。
11.如1所述的支架，所述第一形态由第一长度、第二宽度、第一深度确定，所述第二形态由第二长度、第二宽度、第二深度确定，其中所述第一长度、第二宽度、第一深度中的至少一个不同于所述第二长度、第二宽度、第二深度中的至少一个，以使第一尺寸含有所述第一体积的第一治疗剂并且第二尺寸含有所述第二体积的第二治疗剂。
下列编号的陈述对至少一个实施例的特征进行了描述：
1.一种支架，所述支架具有包括多个部件的本体，所述多个部件限定所述支架的本体，所述本体包括：
第一区域，所述第一区域包括多个第一涂覆物保持件，所述第一区域具有第一密度的第一涂覆物保持件，所述第一区域从所述第一涂覆物保持件排出第一总体积的所述第一治疗剂；
第二区域，所述第二区域包括多个第二涂覆物保持件，所述第二区域具有第二密度的第二涂覆物保持件，所述第二区域从所述第二涂覆物保持件排出第二总体积的所述第二治疗剂；
其中所述第一涂覆物保持件的第一密度大于所述第二涂覆物保持件的第二密度，并且所述第一治疗剂的第一总体积大于所述第二治疗剂的第二总体积。
2.如1所述的支架，各所述多个第一涂覆物保持件具有第一形态，各所述第二涂覆物保持件具有第二形态，所述第一形态不同于所述第二形态。
3.如1所述的支架，各所述多个第一涂覆物保持件具有第一体积，各所述第二涂覆物保持件具有第二体积，所述第一涂覆物保持件的第一体积大于所述第二涂覆物保持件的第二体积。
4.如1所述的支架，各所述多个第一涂覆物保持件具有第一体积，各所述第二涂覆物保持件具有第二体积，所述第一体积等于所述第二体积，各所述多个第一涂覆物保持件具有第一体积的第一治疗剂，各所述多个第二涂覆物保持件具有第二体积的第二治疗剂，所述第一治疗剂的第一体积大于所述第二治疗剂的第二体积。
5.如1所述的支架，所述第一治疗剂以第一排出速率从所述第一涂覆物保持件排出，所述第二治疗剂以第二排出速率从所述第二涂覆物保持件排出。
6.如1所述的支架，所述多个第一涂覆物保持件的至少一部分形成在包括所述支架第一区域的多个所述部件的所述本体之内。
7.如6所述的支架，所述多个第二涂覆物保持件的至少一部分形成在包括所述支架第二区域的多个所述部件的所述本体之内。
8.如1所述的支架，其中所述第一区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合。
9.如8所述的支架，其中所述第二区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合，所述第二区域不同于第一区域。
10.如1所述的支架，还包括第三区域，所述第三区域包括多个第三涂覆物保持件，所述第三区域具有第三密度的第三涂覆物保持件，所述第三区域从所述第三涂覆物保持件排出第三总体积的第三治疗剂，其中所述第三涂覆物保持件的密度不同于所述第一和第二密度，并且所述治疗剂的第三总体积不同于所述治疗剂的第一和第二总体积。
11.如10所述的支架，其中所述第三区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合。
本发明的支架10可由任何合适的生物相容材料制成，包括一或多种聚合物，一或多种金属，或者聚合物和金属的组合。合适材料的例子包括亦生物相容的生物可降解材料或生物可吸收材料。生物可降解系指材料经历作为正常生物过程的一部分分裂或分解成无害化合物。合适的生物可降解材料包括聚乳酸、聚乙醇酸(PGA)、胶原或其他结缔蛋白或天然材料、聚己内酯、透明质酸、粘合蛋白、这些材料的共聚物、及其合成物和组合物以及其他生物可降解材料的组合物。其他可使用的聚合物包括聚酯和聚碳酸酯共聚物类。合适金属的例子包括但不限于不锈钢、钛、钽、铂、钨、金、以及任何上述金属的合金。合适的合金的例子包括铂铱合金、包括埃尔吉洛伊(Elgiloy)和菲诺克斯(Phynox)的钴铬合金、MP35N合金和例如镍钛诺(Nitinol)的镍钛合金。
本发明的支架可由超塑性的镍钛诺或者弹簧钢之类的形状记忆材料制成，或由塑性可变形的材料制成。在使用形状记忆材料的情况下，所述支架可设为记忆形状，然后变形为直径减小形状。当将所述支架加热至转换温度并且不对其作任何限制时，所述支架可自行回复至其记忆形状。
本发明的支架的制造方法包括由管状原料切削或蚀刻出设计图样，由平面片材经切削或蚀刻然后将其卷起，或者由一种或多种交织的金属丝或织带制成。也可使用业界已知或将来开发出来的其他任何合适的技术来制造本文所揭露的本发明的支架。
在一些实施例中，支架、传送系统或组件的其它部分可包括一个或多个可以被成像模式，诸如X光、MRI、超声等检测到的区域、带、涂层、部件等。在一些实施例中，至少一部分支架和/或相邻组件是至少部分射线透不过的。
治疗剂可为药物或者其他药制品，诸如非基因制剂、基因制剂、多胞材料等。合适的非基因治疗剂的例子包括但不限于：肝素、肝素衍生物、脉管细胞生长促进剂、生长因子抑制剂、紫杉醇之类的抗血栓剂。在使用包括基因治疗剂的制剂情况下，所述基因制剂包括但不限于：DNA、RNA及其各自的衍生物及/或组分；刺猬蛋白等。在治疗剂包括分子材料的情况下，所述分子材料可包括但不限于：人类原体及/或非人类原体的细胞，以及它们各自的组分及/或其衍生物。在治疗剂包括聚合物剂的情况下，所述聚合物剂可为聚苯乙烯-聚异丁烯-聚苯乙烯三嵌段共聚物(SIBS)，聚氧化乙烯、硅橡胶及/或其他合适的基质。
上述说明的意图是用于阐述而非穷举的。该描述对于本领域普通技术人员会有许多变化和替代的启示。个别附图中显示的以及以上所描述的各个元件在需要时可以组合或为了组合而作改动。所有这些替代和变化意欲包含在权利要求的保护范围中，其中术语“包括”意味着“包含但不限于”。
此外，从属权利要求中出现的具体特征可以用本发明范围内的其它方式互相合并，从而应当承认本发明，还明确地涉及其它具有从属权利要求特征的任意可能组合的实施例。例如，为了权利要求的公布，下列任何从属权利要求应当可以采用多项从属形式的另一种写法，即其从属于所有的、具有该从属权利要求所引用的全部前提条件的在先权利要求，如果该多项从属的格式在法律范围内是可接受的格式的话(例如，每个直接从属于权利要求1的权利要求，应当换成从属于所有在先的权利要求的写法)。如果法律限制多项从属权利要求的格式，下列从属权利要求应当分别采用另一种写法，即从属于在先的、具有前提条件的权利要求的各单一的从属权利要求格式，而不是以下从属权利要求中所列出的具体权利要求。
本发明的描述到此为止。本技术领域的技术人员可认识到与在此描述的具体实施例的其他等价物，也意欲将其包含在所附权利要求的范围之内。

Claims (22)

1.一种支架，所述支架具有包括多个部件的本体，所述多个部件限定所述支架的本体，所述本体包括：
第一区域，所述第一区域包括第一多个第一涂覆物保持件，各所述第一多个第一涂覆物保持件具有第一体积，各所述第一多个第一涂覆物保持件具有第一体积的第一治疗剂，所述第一治疗剂的第一体积等于所述第一涂覆物保持件的第一体积，所述第一多个第一涂覆物保持件排出第一总体积的第一治疗剂；及
第二区域，所述第二区域包括第二多个第二涂覆物保持件，所述第二多个第二涂覆物保持件具有第二体积，各所述第二多个第二涂覆物保持件具有第二体积的第二治疗剂，所述第二治疗剂的第二体积等于所述第二涂覆物保持件的第二体积，所述第二多个第二涂覆物保持件排出第二总体积的第二治疗剂；
其中所述治疗剂的第一总体积大于所述治疗剂的第二总体积，并且各所述第一多个第一涂覆物保持件的所述第一体积大于各所述第二多个第二涂覆物保持件的所述第二体积。
2.如权利要求1所述的支架，各所述多个部件具有宽度和长度，所述宽度沿所述部件的长度基本保持不变。
3.如权利要求1所述的支架，各所述多个部件具有厚度和长度，所述厚度沿所述部件的长度基本保持不变。
4.如权利要求1所述的支架，所述第一多个第一涂覆物保持件大于所述第二多个第二涂覆物保持件。
5.如权利要求1所述的支架，所述第一多个第一涂覆物保持件的至少一部分形成在包括所述支架第一区域之多个所述部件的所述本体之内。
6.如权利要求5所述的支架，所述第二多个第二涂覆物保持件的至少一部分形成在包括所述支架第二区域之多个所述部件的所述本体之内。
7.如权利要求1所述的支架，所述第一治疗剂不同于所述第二治疗剂。
8.如权利要求1所述的支架，其中所述第一区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合。
9.如权利要求6所述的支架，其中所述第二区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合，所述第二区域不同于所述第二区域。
10.如权利要求1所述的支架，所述第一体积由第一长度、第二宽度、第一深度确定，所述第二体积由第二长度、第二宽度、第二深度确定，其中所述第一长度、第二宽度、第一深度中的至少一个不同于所述第二长度、第二宽度、第二深度中的至少一个。
11.一种支架，所述支架具有包括多个部件的本体，所述多个部件限定所述支架的本体，所述本体包括：
第一区域，所述第一区域具有第一多个第一涂覆物保持件，所述第一涂覆物保持件排出具有第一浓度的第一治疗剂，所述第一多个第一涂覆物保持件具有第一尺寸；及
第二区域，所述第二区域具有第二多个第二涂覆物保持件，所述第二涂覆物保持件排出具有第二浓度的第二治疗剂，所述第二多个第二涂覆物保持件具有第二尺寸；
其中所述第一浓度大于所述第二浓度，并且所述第一尺寸大于所述第二尺寸。
12.如权利要求11所述的支架，各所述多个部件具有宽度和长度，所述宽度沿所述部件的长度基本保持不变。
13.如权利要求11所述的支架，各所述多个部件具有厚度和长度，所述厚度沿所述部件的长度基本保持不变。
14.如权利要求11所述的支架，所述第一多个的数量大于所述第二多个的数量。
15.如权利要求11所述的支架，所述第一区域的部件具有第一密度的第一多个涂覆物保持件，所述第二区域的部件具有第二密度的第二多个涂覆物保持件，所述第一密度大于所述第二密度。
16.如权利要求11所述的支架，所述第一治疗剂具有第一体积，所述第二治疗剂具有第二体积，所述第一体积等于所述第二体积。
17.如权利要求11所述的支架，所述第一治疗剂具有第一体积，所述第二治疗剂具有第二体积，所述第一体积大于所述第二体积。
18.如权利要求11所述的支架，所述多个第一涂覆物保持件的至少一部分形成在包括所述支架第一区域的多个所述部件的所述本体之内。
19.如权利要求11所述的支架，所述多个第二涂覆物保持件的至少一部分形成在包括所述支架第二区域的多个所述部件的所述本体之内。
20.如权利要求11所述的支架，其中所述第一区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合。
21.如权利要求20所述的支架，其中所述第二区域至少位于下列位置中的一个：内腔侧边、外腔侧边、近侧区、远侧区、中间区、分叉支架的主体、对侧区、分叉支架的侧分支、形成所述侧分支的部件、周界部件，以及它们的任何组合，所述第二区域不同于所述第一区域。
22.如权利要求11所述的支架，所述第一尺寸由第一长度、第一宽度、第一深度确定，所述第二尺寸由第二长度、第二宽度、第二深度确定，其中所述第一长度、第一宽度、第一深度中的至少一个不同于所述第二长度、第二宽度、第二深度中的至少一个，以使所述第一尺寸包含所述第一体积的第一治疗剂且所述第二尺寸包含所述第二体积的治疗剂。
CN200880118602XA 2007-11-28 2008-11-12 带有用于具体心门、隆线及侧分支治疗之药阱的分叉支架 Pending CN101878008A (zh)

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