CN101933855A - Recyclable vascular stent and recycling method thereof - Google Patents
Recyclable vascular stent and recycling method thereof Download PDFInfo
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- CN101933855A CN101933855A CN2010102656106A CN201010265610A CN101933855A CN 101933855 A CN101933855 A CN 101933855A CN 2010102656106 A CN2010102656106 A CN 2010102656106A CN 201010265610 A CN201010265610 A CN 201010265610A CN 101933855 A CN101933855 A CN 101933855A
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Abstract
The invention discloses a recyclable vascular stent and a recycling method thereof. The vascular stent comprises a tubular netted framework woven by silks, the end part of the stent is provided with a connecting structure, and the connecting structure forms separable connection with a stent conveyor; the stent can be arranged in the stent conveyor, and can be restored to the original shape after being released; and net holes on the part of the connecting structure are more loosen than other grids, and are used for repeatedly positioning and/or recycling the stent in a vascular cavity. The net holes positioned on the connecting structure on the end part of the stent are easier to stretch and deform than other net holes at other positions, the connecting structure is folded and pulled into a sheath catheter of the stent conveyor, and the rest part of the stent is also collected in the sheath catheter of the stent conveyor, so an operator is greatly convenient to adjust the form of the stent and adjust the proper position of the stent in the vascular cavity and even recycle the stent from the vascular cavity, the repeated positioning and smooth recycling of the vascular stent are realized, and the technical requirement of PTA therapy is better met.
Description
Technical field
The present invention relates to treat or the medical instruments field of auxiliary treatment angiopathy aspect, in particular, improving what relate to is a kind of callable intravascular stent and recovery method thereof.
Background technology
Along with the change of therapeutic treatment pattern and the raising of people's living standard, tangible difference has also appearred in the kind of disease and frequency of disease development, and especially the sickness rate of angiopathy presents the trend that rises year by year.
Angiopathy can be divided into arteries disease and vein blood vessel disease according to vessel position, wherein: described arteries disease can be subdivided into expanding arteries disease and inaccessible type arteries disease again, and described vein blood vessel disease can be subdivided into the sick and vein obstruction disease of vein refluence type again; Described angiopathy can be divided into congenital angiopathy and wound type angiopathy according to the morbidity cause, wherein: described congenital angiopathy can be subdivided into tremulous pulse deformity, venous malformation and hemangioma again, and described wound type angiopathy can be subdivided into tremulous pulse wound, vein wound and arteriovenous associating wound again.
Traditional vascular operation mode, the mode by direct incision lesion vessels reaches the purpose of treatment angiopathy; Because patient's majority of angiopathy is old patient, its health is often comparatively weak, be difficult to bear the huge operation wound that traditional vascular operation is brought, so in recent years, the therapeutic modality of angiopathy changes from the endoluminal vascular therapeutic modality of traditional vascular operation mode to Wicresoft, for example, the puncture shaping surgery PTA that last century, the nineties began progressively to carry out in the world (Percutaneous Transluminal Angiography, angioplasty in the percutaneous lumen of vessels), promptly under the guiding of medical imaging device, by little otch, the intravascular intracavity is sent into special metal rack, is used for the treatment of the disease of blood vessel, reaches and the same therapeutic effect of surgical sectioning operation, and can significantly reduce hemorrhage and complication, shorten recovery time.
Can use various support in a large number in different therapeutic processes, these supports can be transported to the diseased region of blood vessel by conduit, for example: abnormal vascular places such as angiostenosis, hemangioma, arteriovenous fistula; Support of the prior art mostly is the tubular bracket of cut, though the network of metal wire knitted is also arranged, yet actual surgery situation is comparatively complicated sometimes, form and the position of most supports after release is difficult to satisfactory, can't satisfy the requirement of treatment itself, often need to be recovered to earlier in conduit or the sheath pipe and carry out second positioning and release.
But, but the support that has at present can not be realized recyclable and function resetting; And have can only realize partially recycled function, but can't satisfy other requirement, for example, the closed loop tubular bracket of cut, just can't be recovered in the conduit again in case discharge fully, and the non-constant of its bending property, can not in the blood vessel of extremity or bending, use; The support that also has draws in together by some sleeve pipes, and an end is fixed with the nut of metal, is connected with push rod, tinsel and sleeve pipe all easily are deposited in nut end when reclaiming, produce very big resistance, need to adopt thicker conduit could realize reclaiming, be not suitable in less blood vessel, using.
Therefore, prior art still haves much room for improvement and develops.
Summary of the invention
The objective of the invention is to, a kind of callable intravascular stent and recovery method thereof are provided, form and position after can adjusting it and discharging are realized the resetting of intravascular stent and are reclaimed function smoothly, to satisfy the requirement of PTA treatment.
Technical scheme of the present invention is as follows:
A kind of callable intravascular stent comprises a pipe type netted skeleton that is woven into silk, and the one end is provided with a syndeton, is used for forming disengageable the connection with a bracket conveyer; Described support can be packed in the described carrier, and described support can restore to the original state after discharging from described bracket conveyer; Wherein: the average-size that is positioned at syndeton place mesh on the described skeleton, average-size greater than other position mesh on the described skeleton, described support can be drawn in and from an end retraction of described bracket conveyer by described syndeton, be used in the lumen of vessels resetting and/or reclaim described support.
Described callable intravascular stent, wherein: described syndeton comprises plural at least protuberance; Described protuberance is evenly distributed on the periphery of described support one end; Each protuberance all comprises a mesh, is used to connect described bracket conveyer.
Described callable intravascular stent, wherein: described each protuberance all is made of individual thread.
Described callable intravascular stent, wherein: described protuberance is provided with the latch closure that adaptive described bracket conveyer connects.
Described callable intravascular stent, wherein: cross sections different on the described support is adhered on the summit of described protuberance separately, constitutes multistage braided support.
Described callable intravascular stent, wherein: the second rank protuberance of described multistage braided support is provided with latch closure, and the first rank silk of described multistage braided support passes described latch closure.
Described callable intravascular stent, wherein: at the other end of described support, adjacent two rhizoids twine mutually and are pigtail shape knot.
Described callable intravascular stent, wherein: the choked flow film is set on the surface of described support.
A kind of recovery method of intravascular stent, wherein:
Adopt callable intravascular stent as claimed in claim 1;
Adopt a bracket conveyer, described bracket conveyer comprises a recovery structure, and described recovery structure comprises a sheath pipe, a push rod and adapter, and described push rod and adapter all pass described sheath pipe;
The adapter of described recovery structure is connected with the syndeton of described support, makes an end of support and described recovery structure be in connection status;
Move described recovery structure, draw described syndeton in and it is drawn in the described sheath pipe;
Move described push rod, described support is released the sheath pipe, keep described connection status;
Above-mentioned two action cooperations are carried out, with resetting in lumen of vessels and the described support of recovery.
The recovery method of described intravascular stent, wherein: described adapter is a recovery silk; In described connection status, an end of described recovery silk passes described sheath pipe earlier, passes the mesh in the described syndeton again, returns then in the described sheath pipe and pulls out.
The recovery method of described intravascular stent, wherein: described adapter comprises the recovery silk that a plurality of hooks at one end are set; In described connection status, described hook is hooked on the mesh in the described syndeton one to one.
The recovery method of described intravascular stent, wherein: described adapter comprises the recovery silk that hook at one end is set, and also has a closure circle that passes the mesh in the described syndeton; In described connection status, the hook of described recovery silk is hooked on the described closed circle.
The recovery method of described intravascular stent, wherein: described push rod is the tubular of hollow perforation, described recovery silk passes push rod.
The recovery method of described intravascular stent, wherein: described adapter comprises an anchoring filament and the recovery silk of a draw ring at one end is set; In described connection status, described recovery silk ribbon has an end of draw ring to pass mesh in the described syndeton, and described anchoring filament passes described draw ring.
The recovery method of described intravascular stent, wherein: described adapter comprises that an anchoring filament and is converted into bifilar recovery silk; In described connection status, the bifilar end that is converted into of described recovery silk passes mesh in the described syndeton, entangles an end of anchoring filament again.
The recovery method of described intravascular stent, wherein: described push rod is the tubular of hollow perforation, described recovery silk and anchoring filament all pass push rod.
The recovery method of described intravascular stent, wherein: described adapter is arranged on the push rod, and described adapter is a bayonet unit; In described connection status, the bayonet unit of described push rod passes the mesh of described syndeton.
A kind of callable intravascular stent provided by the present invention and recovery method thereof, since an end of support adopted weave loose relatively syndeton, and form disengageable the connection with bracket conveyer, by drawing described syndeton in and drawing in the sheath pipe of described bracket conveyer, the remainder of support also can be taken in the described bracket conveyer sheath pipe, greatly facilitate the operator and adjust the form of described support, and adjust the correct position of described support in lumen of vessels, or even described support reclaimed from lumen of vessels, realize the resetting of intravascular stent and reclaimed function smoothly, thereby satisfied the specification requirement of PTA treatment preferably.
Description of drawings
Fig. 1 is the single order intravascular stent axonometric chart in the embodiment of the invention 1;
Fig. 2 is the single order intravascular stent axonometric chart that has closing in the embodiment of the invention 2;
Fig. 3 is the multistage intravascular stent axonometric chart in the embodiment of the invention 3;
Fig. 4 is the multistage intravascular stent axonometric chart of band button in the embodiment of the invention 4;
Fig. 5 is the multistage intravascular stent axonometric chart of band pigtail shape knot in the embodiment of the invention 5;
Fig. 6 adopts sub-thread to reclaim the process sketch map that silk reclaims intravascular stent in the embodiment of the invention 6;
Fig. 7 adopts the recovery silk of band draw ring and the process sketch map that anchoring filament reclaims intravascular stent in the embodiment of the invention 7;
Fig. 8 adopts the bifilar process sketch map that silk reclaims intravascular stent that reclaims in the embodiment of the invention 8;
Fig. 9 adopts the process sketch map that reclaims intravascular stent with the recovery silk of a plurality of hooks in the embodiment of the invention 9;
Figure 10 is the process sketch map that adopts the bridle catcher recovery intravascular stent of band bayonet unit in the embodiment of the invention 10;
Figure 11 adopts closed circle and is with the recovery silk of linking up with to reclaim the process sketch map of intravascular stent in the embodiment of the invention 11.
The specific embodiment
Below with reference to accompanying drawing, the specific embodiment of the present invention and embodiment are described in detail.
A kind of callable intravascular stent of the present invention, one of its specific embodiment as shown in Figure 3, comprises a pipe type netted skeleton, described support can adopt single or many one metal wire braidings to form, and also can adopt to have the stronger nonmetal wire braiding composition of rebound performance.Support can be compressed, and removes after the external force resilient again.Be provided with one at the initial braiding end of described support and have the syndeton of loose relatively mesh, be used for disengageable connection of formation between described support and a bracket conveyer.This syndeton place is provided with a plurality of mesh, described mesh is more loose than other mesh on the described support, that is to say, be positioned at the average-size of syndeton place mesh on the described skeleton, average-size greater than other position mesh on the described skeleton, and, power effect outside the former than the easier distortion that is stretched of the latter.Described support can be drawn in and from an end retraction of described bracket conveyer by described syndeton.The shape of described syndeton can the conversion setting with the action of the recovery structure on the described bracket conveyer, be that syndeton can be drawn in and be drawn in the sheath pipe of described bracket conveyer, also can be pushed out the sheath pipe and expand reinstatement, so that resetting and/or reclaim described support in lumen of vessels.
Correspondingly, the recovery method of a kind of intravascular stent of the present invention, one of its specific embodiment comprises the pipe type netted skeleton that recovery is formed with metal wire knitted, the one end is provided with a syndeton, is used for forming disengageable the connection with a bracket conveyer.Described support can be packed in the described carrier, and described support can restore to the original state after discharging from described bracket conveyer.Wherein: the average-size that is positioned at syndeton place mesh on the described skeleton, average-size greater than other position mesh on the described skeleton, described support can be drawn in and from an end retraction of described bracket conveyer by described syndeton, be used in the lumen of vessels resetting and/or reclaim described support.As shown in Figure 6, adopt a described recyclable intravascular stent and a bracket conveyer; Described bracket conveyer comprises a recovery structure, and described recovery structure comprises a sheath pipe, a push rod and adapter, and described push rod and adapter all pass described sheath pipe.Recovery structure with described bracket conveyer is connected with the syndeton of described support earlier, entangles the mesh of described syndeton by the adapter of described recovery structure, makes an end of support and described recovery structure be in connection status.Then by the recovery structure on the described bracket conveyers of action such as drawing, pull, carry, drag of appropriate strength, draw described syndeton in and it is drawn in the sheath pipe of described bracket conveyer, described syndeton and then the remainder of described support brought in the sheath pipe, move described push rod, described support is released the sheath pipe, keep described connection status.The described recovery structure that will move cooperates and carries out with the described push rod of action, with resetting in lumen of vessels and the described support of recovery.
In the preferred embodiment of callable intravascular stent of the present invention and recovery method thereof, described support can adopt one or more tinsel and the mould rod that big or small length is suitable, weaves the structure that forms grid duct shape again through Overheating Treatment earlier.Described mould rod surface is provided with a plurality of nearer fixtures apart, and tinsel is hung on these fixtures, holds the two ends of every one metal wire, and described support takes up one's knitting on the mould rod.Described tinsel begins to be staggered into grid after turning back on the fixture, will loosen relatively at the mesh of the initial braiding end of described support.The grid that these edges are outstanding forms the syndeton of band mesh, is used for being connected with bracket conveyer, is implemented in the lumen of vessels resetting and/or reclaims described support.Described support can because of when braiding hang the mode of silk and position differently possess the slightly multiple syndeton of difference, as single order braided support or multistage braided support, to adapt to connected modes different in the practical situation and/or way of recycling.Used silk wiry footpath scope can be between 0.01mm～0.8mm, and its number can be that odd number also can be even numbers; The acute angle angular range of grid can be between 5 ° to 90 ° on the described support; The length range of described support can be 5～500mm, and diameter range can be 1～50mm.The weaving manner of described support can be the longitude and latitude weaving, and a rhizoid is pressed another rhizoid, also can be that a rhizoid is pressed two rhizoids in addition, or two rhizoids is pressed two rhizoids in addition.
Preferably adopt the super-elastic shape memory alloy material, for example nitinol alloy wire etc. to guarantee the superior elasticity of described support, has good radial support performance and axial bending performance after release.Nitinol alloy wire with suitable silk footpath is woven into the required pipe type netted structure that comprises syndeton earlier, reaches the required length of support, and after heat treatment support has and the corresponding stable diameter of mould rod again, takes off support from the mould rod then.Described support has good radial support and axial bending, uses with the vascular lesion position that is adapted at crooked position.In addition, the processing of can closing up of the tail end of described support to avoid occurring the phenomenon of filoselle in the process of folding and unfolding repeatedly, also can avoid tinsel to stab blood vessel, and the mode of closing in has back volume, welds, plaits the hair/spring and binding binding etc.In addition, also can carry out overlay film and handle described support, for example, the choked flow film sewed up or sintering on wire netting, guarantee that blood flows through from the inner chamber of described support, the effect that completely cuts off with the blood vessel that plays blood and pathological changes.The material of choked flow film can be PTFE (Poly tetra fluoro ethylene, politef), PET (Polyethylene terephthalate, polyester), PE (Polyethylene, polyethylene), nylon, polyurethane, latex or silica gel or the like.
Because the syndeton that described support has a braiding to form can be connected reliably with described bracket conveyer, realizes the function that pushes and/or reclaim.The function that pushes reclaims comparatively simple relatively, a push rod is set in the sheath pipe of described bracket conveyer can realizes the function that pushes.In the different specific embodiment, described push rod can have different structure, can be solid hopkinson bar, also can be the pipe that hollow connects.And the relatively variation of realization of reclaiming function, it is different with the adapter connected mode of the recovery structure of described bracket conveyer that its main variation is, specifically can roughly be divided into and flexibly connect and be rigidly connected, described flexible connection mode comprises that snare connects and is connected with hook etc., and described being rigidly connected comprises the buckle connection and be threaded etc.But no matter be any connected mode, described support is in the process that reclaims, and all the syndeton of support is drawn in earlier before this, is drawn in the described sheath pipe again, and then, the remainder of support is also drawn in the sheath pipe.Below, will specifying in the mode of embodiment, the technical characterictic between the embodiment allows combined crosswise to constitute new technical scheme.
Embodiment 1:
As shown in Figure 1, can bore the hole of some at the sustained height that braiding mould rod makes progress from the bottom, and insert the bar of hanging silk usefulness in the hole, tinsel 101 is turned back to hang over becomes bifilar silk on the bar.To overwork the tinsel in a week again and weave, and can adopt a rhizoid to press the mode of a rhizoid during braiding, be woven into certain length after, support is fixed on this braiding mould rod, thereby and heat-treats the braided support of producing single order.
Embodiment 2:
As shown in Figure 2, at the termination of support braiding end 110, can adopt back the processing of closing up of the mode of volume, thereby can avoid described support injured blood vessel.
Embodiment 3:
As shown in Figure 3, can bore the hole of some at the differing heights that braiding mould rod makes progress from the bottom, there is plural at least hole at the sustained height place, and the axis projection of described central point of hole is along weaving mould rod periphery or edge line uniform distribution or being symmetrical arranged.Insert the bar of hanging silk usefulness in the hole, tinsel is turned back to hang over becomes bifilar silk on the different bar of height.Tinsel 201 shown in the figure is one of tinsel that is hung on the highest extension screw mandrel in position on the mould rod.The tinsel that overworks a week is woven, can adopt a rhizoid to press the mode of a rhizoid during braiding, be woven into certain-length after, support is fixed on the braiding mould rod, heat-treat.What make like this is multistage braided support, and the syndeton that is positioned at its initial braiding end 210 comprises the plural first rank protuberance 201a at least; The described first rank protuberance 201a can be evenly distributed on the periphery of the initial braiding end 210 of support.The second rank protuberance is also near the initial braiding end 210 of support, and is still, more farther than the first rank initial braiding end margin of protuberance distance.Each protuberance all comprises a mesh, is used to connect described bracket conveyer.The summit of described protuberance can be adhered to cross sections different on the described support separately; Each protuberance all is made of individual thread.Such syndeton, the contained tinsel of its outer rim is less than the tinsel that the support remainder comprises, easier being compressed in the sheath pipe, the braided support recyclability that adopts multistage weaving manner to make thus is better, and the resistance during recovery is littler.
Embodiment 4:
As shown in Figure 4, tinsel pitch of the laps on the bar of extension silk usefulness higher on braiding mould rod when hanging silk, every rhizoid can be divided into two.All the other tinsels are hung on the bar of extension silk usefulness of the different braiding mould rod of height and be bent into bifilar silk.Tinsel 201 shown in the figure is one of tinsel that is hung on the highest extension screw mandrel in position on the mould rod, hangs pitch of the laps on the screw mandrel, forms the latch closure 201b of the first rank protuberance.Weave after overworking the tinsel in a week, can adopt a rhizoid to press the mode of a rhizoid during braiding, be woven into certain-length after, support is fixed on the braiding mould rod, heat-treat.In the syndeton of its initial braiding end 210, the latch closure 201b of the first rank protuberance is used for being connected with described bracket conveyer, and what make like this is the multistage braided support that initial braiding end 210 has latch closure.In addition, use the same method, also can on the second rank protuberance of the initial braiding end of described multistage braided support, latch closure be set.The connection of the adaptive described bracket conveyer of described latch closure can reduce the deflection of tinsel at bending part, promotes anti-fatigue performance.
Embodiment 5:
As shown in Figure 5, promptly stop braiding end 320 at the support tail end, the mode of available welding welds together adjacent two one metal wires, makes support tinsel in compression and release can not scatter and stabs blood vessel.Two adjacent rhizoids can also be intertwined becomes pigtail shape knot 321, makes its more difficult scattering.Can sheathed heat-shrinkable T bush outside described pigtail shape knot 321, avoid the effect of filoselle with further reinforcement.
When hanging silk, from weaving the tinsel that higher extension screw mandrel sends on the mould rod, can meet in pairs on the lower extension screw mandrel, form a latch closure with another one metal wire pitch of the laps on lower extension screw mandrel, and the aforementioned a pair of silk braid that crosses is advanced in the latch closure.On one the second rank protuberance as shown in the figure a latch closure 202c is arranged, the first rank silk 201 passes from latch closure.Then all tinsels have been woven together, support has been fixed on the braiding mould rod, heat-treated.What make like this also is the multistage braided support that latch closure is arranged, and the first rank grid of its syndeton is more sparse, in the easier income sheath pipe.And the tinsel on first rank passes second rank latch closure wiry, and described latch closure makes the tinsel on first rank be not easy to scatter, and has increased the support force and the stability of support.
Embodiment 6:
As shown in Figure 6, the way of recycling of described support 400 comprises that employing one sub-thread reclaims silk 420 operations of carrying out, described sub-thread is reclaimed silk 420 in hollow push rod 410, passes, pass the mesh on the syndeton of described support 400 after, return in the described push rod 410 and pull out.The recovery structure of carrier comprises sheath pipe (not shown), push rod 410 and reclaims silk 420, and push rod 410 can be the hollow tubule of spring Coil-up.For example, a rope can be passed a plurality of mesh on the syndeton of described support, then the formation rope sling be closed up at the two ends of rope.Again this rope sling is passed the other end of the push rod of bracket conveyer to bracket conveyer.On push rod, rope ends all is exposed at outside sheath pipe and the push rod with the sheath pipe box.Firmly hold rope, the syndeton of support is drawn in, draw in again in the sheath pipe of bracket conveyer, all be included into the sheath pipe until entire bracket.During propelling movement, use push rod outwards to push support, support is released the sheath pipe be released in the blood vessel, temporarily rope sling can be stayed on the support.During recovery, haul rope sling, firmly draw and draw in support in the sheath pipe from the other end of bracket conveyer.As the need resetting, only need mobile sheath pipe, again stent pushing is gone out the sheath pipe.Up to confirming that support is placed on the appropriate location, its form is also suitable, and rope sling is extracted out from the syndeton of support the most at last, and rope sling is together withdrawn with the sheath pipe.Described push rod 410 also can be a solid hopkinson bar, at this moment reclaims silk 420 and is pasting push rod 410 and directly passing the sheath pipe, and other operating process is constant.
Embodiment 7:
As shown in Figure 7, the way of recycling of described support 400 comprises the operation that the recovery silk 520 that adopts an end that one draw ring 520a is set carries out, described recovery silk 520 ends that have draw ring 520a are passed in hollow push rod 410, after passing the mesh 401 on the syndeton of described support 400 again, pass described draw ring 520a with an anchoring filament 521.For example, can set up and have certain inflexible recovery silk, circle of one end coiled, promptly described draw ring.The end that circle is arranged that reclaims silk is passed all mesh on the syndeton of support, one of reuse has certain inflexible anchoring filament and passes the circle that reclaims silk, and is placed in the support, reclaims silk and keeps a tensioned state.This two rhizoid is passed the other end of the push rod of bracket conveyer to bracket conveyer, form recovery structure, the syndeton of described support is drawn in draw in the sheath pipe (not shown) again.During propelling movement, use push rod outwards to push support, support is released the sheath pipe be released in the blood vessel, temporarily do not free anchoring filament.During recovery, tighten and reclaim silk and anchoring filament, haul the whole recovery structure, firmly draw and draw in support in the sheath pipe.Discharge support once more, carry out resetting, all suitable up to the position and the form of support, again anchoring filament is extracted out from the circle that reclaims silk, anchoring filament is returned from the sheath pipe with the recovery silk remove at last.Described push rod 410 also can be a solid hopkinson bar, at this moment reclaims silk 520 and is pasting push rod 410 and directly passing the sheath pipe, and other operating process is constant.
Embodiment 8:
As shown in Figure 8, the way of recycling of described support 400 comprises 620 operations of carrying out of employing one bifilar recovery silk, described bifilar recovery silk 620 is passed in hollow push rod 410, after passing the mesh 401 on the syndeton of described support 400, pass described bifilar recovery silk 620 with an anchoring filament 621.For example, a rhizoid turned back forms bifilar recoverys silk, and turning back of will reclaiming again thread held all mesh on the syndeton of passing support.Have certain inflexible anchoring filament with one and pass the recovery silk, and be placed in the support.This two rhizoid is passed the other end of the push rod 410 of bracket conveyer to bracket conveyer, form recovery structure, the syndeton of described support is drawn in draw in the sheath pipe (not shown) again; During propelling movement, use push rod outwards to push support, support is released the sheath pipe be released in the blood vessel; During recovery, silk and anchoring filament are reclaimed in tension, firmly draw and draw in support in the sheath pipe.After treating that support location suitably, discharge support more fully, return and remove anchoring filament, will reclaim silk at last and time remove and to free.Described push rod 410 also can be a solid hopkinson bar, at this moment reclaims silk 620 and is pasting push rod 410 and directly passing the sheath pipe, and other operating process is constant.
Embodiment 9:
As shown in Figure 9, the way of recycling of described support 400 comprises the operation of adopting a plurality of recovery silks 720 that hook 720a at one end is set to carry out, band hook 720a one end that reclaims silk 720 is passed in hollow push rod 410, be hooked on one to one on the mesh 401 in the syndeton of described support 400.For example, there is the recovery silk of a plurality of hooks to hook the mesh of support with front end.During propelling movement, use push rod outwards to push support, support is released the sheath pipe be released in the blood vessel, the syndeton of support does not temporarily break away from described hook.During recovery, support is drawn and drawn in to pulling whole recovery structure firmly in sheath pipe (not shown).When discharging support, push away some push rods forward, shake described hook a little, utilize the resilience force of support, the syndeton of described hook and support is freed.Described push rod 410 also can be a solid hopkinson bar, at this moment reclaims silk 720 and is pasting push rod 410 and directly passing the sheath pipe, and other operating process is constant.
Embodiment 10:
As shown in Figure 10, the way of recycling of described support 400 comprises the operation that the push rod 410 of employing one band bayonet unit 410a carries out, and a plurality of mesh 401 in described support 400 syndetons are nested on the bayonet unit 410a of described push rod 410.For example, as shown in Figure 10,, pin 410a is passed the mesh 401 of described support 400 syndetons, the syndeton of support 400 is fixed on this push rod 410 with a push rod 410 that has pin 410a on its surface.Then, push rod 410 is passed sheath pipe 820, the syndeton of described support 400 is drawn in draw in the sheath pipe 820, the top of pin 410a contacts with sheath pipe 820 inwalls on the push rod 410, because of stopping of sheath pipe 820 inwalls, the syndeton of support 400 can not get loose from pin 410a.During propelling movement, use push rod 410 outwards to push support 400, support 400 is released sheath pipe 820 be released in the blood vessel, do not allow pin 410a break away from sheath pipe 820, the syndeton of support 400 does not temporarily break away from push rod 410.During recovery, use push rod 410 pulling whole recovery structures, firmly draw and draw in support 400 in sheath pipe 820.When discharging support 400, push rod 410 is released sheath pipe 820 outer certain distances forward, allow pin 410a stretch out outside the sheath pipe 820, shake push rod 410 a little, utilize the resilience of support 400, the syndeton and the push rod 410 of support 400 are freed.
Embodiment 11:
As shown in Figure 11, the way of recycling of described support 400 comprises the operation of adopting a closure circle 920 that passes described support 400 all mesh 400 of syndeton outer most edge to carry out, the recovery silk 921 that one end is provided with a hook 921a passes in hollow push rod 410, is hooked on the described closed circle 920.For example, as shown in Figure 11, in the mesh 401 of support 400 syndetons, penetrate a flexible rings 920; Have the tinsel 921 of linking up with 921a with one and hook flexible rings 920 on the support 400, tinsel 921 is passed described hollow push rod 410, again with the sheath pipe box on push rod 410, catch tinsel 921 and push rod 410 that support 400 is drawn at last and draw in the sheath pipe (not shown).During propelling movement, use push rod outside 410, to push support 400, support 400 is released the sheath pipe be released in the blood vessel, temporarily do not free hook 921a.During recovery, use hook 921a to hold flexible rings 920, utilize flexible rings 920 firmly to draw and draw in support 400 in the sheath pipe.When discharging support 400, will link up with 921a and flexible rings 920 is freed.Described push rod 410 also can be a solid hopkinson bar, at this moment reclaims silk 921 and is pasting push rod 410 and directly passing the sheath pipe, and other operating process is constant.
Embodiment 12:
Earlier internal layer PTFE film is wrapped in outside the overlay film internal layer mould, again with the support fixed cover of braiding in PTFE film outside, after outer PTFE film is wrapped in the support outside, thereby support is embedded in the centre of inside and outside two-layer PTFE film.After putting the outer mould of overlay film, at high temperature carry out sintering, sintering temperature is the 400-420 degree, can produce the braided support of overlay film like this, and the support of overlay film can have isolated blood flow, makes blood only flow through in the intermediary tube chamber of support.
This shows, be compressible to the interior support of sheath pipe of described carrier, be positioned in the lumen of vessels by carrier, the support of releasing from described sheath pipe can restore to the original state and can be recycled in the sheath pipe.This support has columnar braiding skeleton, skeleton has initial braiding end and stops the braiding end, at described initial braiding end a syndeton that mesh is sparse relatively is set, between the recovery structure of this syndeton and described bracket conveyer, forms disengageable annexation.And the syndeton of described initial braiding end is provided with a plurality of protuberances that extend vertically, and is as a whole with the skeleton braiding, and each protuberance all is made of individual thread and a mesh is arranged, and supplies the adapter of described recovery structure to pass.Described protuberance can become axial symmetrical distribution, thereby can make described support keep balance, is difficult for run-off the straight during recovery.And the length that each protuberance extends vertically can be different, thereby avoid all protuberances to be drawn in the described sheath pipe simultaneously or be compressed on the same position in the described sheath pipe, the resistance when reducing to pull back.In the process that discharges described support, as long as described syndeton is not freed fully, the described syndeton of just can pulling back is retracted in the described sheath pipe, continues to pull back again and then can realize reorientating, reclaim and/or discharging once more of described support with in the described sheath pipe of whole described support retraction.
Should be understood that, for those of ordinary skills, can be improved according to the above description or conversion, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.
Claims (17)
1. a callable intravascular stent comprises a pipe type netted skeleton that is woven into silk, and the one end is provided with a syndeton, is used for forming disengageable the connection with a bracket conveyer; Described support can be packed in the described carrier, and described support can restore to the original state after discharging from described bracket conveyer; It is characterized in that: the average-size that is positioned at syndeton place mesh on the described skeleton, average-size greater than other position mesh on the described skeleton, described support can be drawn in and from an end retraction of described bracket conveyer by described syndeton, be used in the lumen of vessels resetting and/or reclaim described support.
2. callable intravascular stent according to claim 1 is characterized in that: described syndeton comprises plural at least protuberance; Described protuberance is evenly distributed on the periphery of described support one end; Each protuberance all comprises a mesh, is used to connect described bracket conveyer.
3. callable intravascular stent according to claim 2 is characterized in that: described each protuberance all is made of individual thread.
4. callable intravascular stent according to claim 3 is characterized in that: described protuberance is provided with the latch closure that adaptive described bracket conveyer connects.
5. callable intravascular stent according to claim 2 is characterized in that: cross sections different on the described support is adhered on the summit of described protuberance separately, constitutes multistage braided support.
6. callable intravascular stent according to claim 5 is characterized in that: the second rank protuberance of described multistage braided support is provided with latch closure, and the first rank silk of described multistage braided support passes described latch closure.
7. callable intravascular stent according to claim 1 is characterized in that: at the other end of described support, adjacent two rhizoids twine mutually and are pigtail shape knot.
8. callable intravascular stent according to claim 1 is characterized in that: on the surface of described support the choked flow film is set.
9. the recovery method of an intravascular stent is characterized in that:
Adopt callable intravascular stent as claimed in claim 1;
Adopt a bracket conveyer, described bracket conveyer comprises a recovery structure, and described recovery structure comprises a sheath pipe, a push rod and adapter, and described push rod and adapter all pass described sheath pipe;
The adapter of described recovery structure is connected with the syndeton of described support, makes an end of support and described recovery structure be in connection status;
Move described recovery structure, draw described syndeton in and it is drawn in the described sheath pipe;
Move described push rod, described support is released the sheath pipe, keep described connection status;
Above-mentioned two action cooperations are carried out, with resetting in lumen of vessels and the described support of recovery.
10. the recovery method of intravascular stent according to claim 9 is characterized in that: described adapter is one to reclaim silk; In described connection status, an end of described recovery silk passes described sheath pipe earlier, passes the mesh in the described syndeton again, returns then in the described sheath pipe and pulls out.
11. the recovery method of intravascular stent according to claim 9 is characterized in that: described adapter comprises the recovery silk that a plurality of hooks at one end are set; In described connection status, described hook is hooked on the mesh in the described syndeton one to one.
12. the recovery method of intravascular stent according to claim 9 is characterized in that: described adapter comprises the recovery silk that hook at one end is set, and also has a closure circle that passes the mesh in the described syndeton; In described connection status, the hook of described recovery silk is hooked on the described closed circle.
13. the recovery method according to arbitrary described intravascular stent in the claim 10 to 12 is characterized in that: described push rod is the tubular of hollow perforation, and described recovery silk passes push rod.
14. the recovery method of intravascular stent according to claim 9 is characterized in that: described adapter comprises an anchoring filament and the recovery silk of a draw ring at one end is set; In described connection status, described recovery silk ribbon has an end of draw ring to pass mesh in the described syndeton, and described anchoring filament passes described draw ring.
15. the recovery method of intravascular stent according to claim 9 is characterized in that: described adapter comprises that an anchoring filament and is converted into bifilar recovery silk; In described connection status, the bifilar end that is converted into of described recovery silk passes mesh in the described syndeton, entangles an end of anchoring filament again.
16. the recovery method according to claim 14 or 15 described intravascular stents is characterized in that: described push rod is the tubular of hollow perforation, and described recovery silk and anchoring filament all pass push rod.
17. the recovery method of intravascular stent according to claim 9 is characterized in that: described adapter is arranged on the push rod, and described adapter is a bayonet unit; In described connection status, the bayonet unit of described push rod passes the mesh of described syndeton.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5383892A (en) * | 1991-11-08 | 1995-01-24 | Meadox France | Stent for transluminal implantation |
| CN1331956A (en) * | 2001-07-06 | 2002-01-23 | 周星 | Reusable temporary thrombus filter |
| EP1470830A1 (en) * | 2003-04-25 | 2004-10-27 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
| CN101299977A (en) * | 2005-10-20 | 2008-11-05 | 德国Pfm医用产品有限公司 | Stent for temporary fitting in a body cavity |
-
2010
- 2010-08-26 CN CN2010102656106A patent/CN101933855B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5383892A (en) * | 1991-11-08 | 1995-01-24 | Meadox France | Stent for transluminal implantation |
| CN1331956A (en) * | 2001-07-06 | 2002-01-23 | 周星 | Reusable temporary thrombus filter |
| EP1470830A1 (en) * | 2003-04-25 | 2004-10-27 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
| CN101299977A (en) * | 2005-10-20 | 2008-11-05 | 德国Pfm医用产品有限公司 | Stent for temporary fitting in a body cavity |
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