CN102058900B - Waterproof liquid bandage for wound surface protection and preparation method thereof - Google Patents
Waterproof liquid bandage for wound surface protection and preparation method thereof Download PDFInfo
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- CN102058900B CN102058900B CN 201010584845 CN201010584845A CN102058900B CN 102058900 B CN102058900 B CN 102058900B CN 201010584845 CN201010584845 CN 201010584845 CN 201010584845 A CN201010584845 A CN 201010584845A CN 102058900 B CN102058900 B CN 102058900B
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Abstract
The invention relates to a waterproof liquid bandage for wound surface protection and a preparation method thereof. The waterproof liquid bandage comprises the following components in the terms of 100g of liquid bandage: 60g-90g of absolute ethyl alcohol, 1g-10g of ethyl acetate, 5g-15g of nitrated cellulose, 0.5g-2g of tributyl acetocitrate, 1g-5g of isopropyl palmitate and 0.1g-2g of vitamin E acetate. The waterproof liquid bandage for wound surface protection is a novel liquid bandage with dual functions of physical containment and wound healing enhancement, is safe and environment-friendly, is high in film-forming speed, simple and convenient to use and good in comfort and is mainly used for prevention of superficial skin wound surfaces such as scratching and incised wound and the like.
Description
Technical field
The present invention relates to a kind of wound surface protection with liquid binder and preparation method thereof, relate in particular to a kind of wound surface protection liquid binder and preparation method thereof with water proofing property.
Background technology
In daily life and work, the wound of skin surface usually can take place because of various accidents in people, and handling the most frequently used dressing for this epidermis wound is common adhesive bandage.Common adhesive bandage generally is made up of gauze, rubber adhesive and active drug composition three parts that are attached on the rubber adhesive.Gauze plays the support effect, and the function that absorbs the wound transudate is arranged; Rubber adhesive adheres to skin surface and plays fixation; That the active drug composition rises is antibiotic, the function of antiinflammatory, hemostasis.Common adhesive bandage also can influence attractive in appearance aspect waterproof, resistance bacterium, breathability and the range of application certain limitation being arranged during use.For meeting the market requirement, a lot of producers have both at home and abroad all released a kind of novel Wound protection product--liquid binder in recent years.
The liquid binder is a kind of novel wound surface protective material, mainly constituted by filmogen and solvent, the interpolation that also has have curative functional mass or a spray etc.It has overcome traditional wound surface protective material, as binder, adhesive bandage etc. are poor to irregular wound face or some human body wound site protective capacities of being inconvenient to use, water-proof breathable properties is bad, helpless to the bacterial infection of wound, use inaesthetic shortcoming, in clinical practice, obtained wound surface protection effect preferably.
In the existing prior art that is used for scratch, incised wound, slight burn and scald, surgical wound etc. about the liquid binder, be that form with spray or glue spraying agent exists mostly, though that the product of this kind dosage form has is easy to use, film forming speed fast, the effect of waterproof and minimizing cicatrization, have also that nozzle stops up easily, the aerosol push agent is harmful or contaminated environment, the spray film thickness is difficult for grasping and shortcomings such as action effect persistency difference.
Also having some liquid binder products is that form with liniment or liniment exists, though added purified water as solvent in the product of this kind dosage form, has the safety of use, characteristics easily, has certain shortcoming aspect water preventing ability, the film forming speed.
Summary of the invention
The present invention is directed to existing liquid binder above shortcomings, a kind of wound surface protection liquid binder and preparation method thereof with water proofing property is provided.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of wound surface protection with water proofing property comprises dehydrated alcohol, ethyl acetate, nitrocellulose, tributyl 2-acetylcitrate, isopropyl palmitate and vitamin e acetate with the liquid binder, in the liquid binder of 100 grams, comprise the dehydrated alcohol of 60 grams～90 grams, the ethyl acetate of 1 gram～10 grams, the nitrocellulose of 5 grams～15 grams, the tributyl 2-acetylcitrate of 0.5 gram～2 grams, the isopropyl palmitate of 1 gram～5 grams and the vitamin e acetate of 0.1 gram～2 grams.
Further, the pH value of described liquid binder is 6.0～8.0.
The present invention also provides a kind of technical scheme that solves the problems of the technologies described above as follows: the preparation method that a kind of wound surface with water proofing property protects with the liquid binder may further comprise the steps:
1) dehydrated alcohol and ethyl acetate are mixed the uniform mixed liquor of formation, wherein, to prepare the liquid binders of 100 grams, the amount of dehydrated alcohol is 60 grams～90 grams, and the amount of ethyl acetate is that 1 gram～10 restrains;
2) in mixed liquor, add tributyl 2-acetylcitrate, isopropyl palmitate and vitamin e acetate and stir successively, form transparent and homogeneous solution, wherein, to prepare the liquid binder of 100 grams, the amount of tributyl 2-acetylcitrate is 0.5 gram～2 grams, the amount of isopropyl palmitate is 1 gram～5 grams, and the amount of vitamin e acetate is 0.1 gram～2 grams;
3) add nitrocellulose and stir and make its dissolving in transparent and homogeneous solution, wherein, to prepare the liquid binders of 100 grams, nitrocellulosic amount is 5 grams～15 grams;
4) will be dissolved with nitrocellulosic solution and filter, the insoluble impurity and the fiber filter that contain in the nitrocellulose solution are removed, and carry out fill again and get final product.
The invention has the beneficial effects as follows: the wound surface protection that the present invention has water proofing property is the new liquid binder that has physical protection, promotes the wound healing dual-use function with the liquid binder, comprise macromolecule filming material, organic solvent, cosolvent and functional materials, wherein, the macromolecule filming material plays the protection buffer action to wound, organic solvent and cosolvent play dissolution and have quick volatility, and functional materials plays a part to promote wound healing and reduce cicatrization.Liquid binder product safety of the present invention environmental protection, film forming speed is fast and easy to use, comfortableness is good, is mainly used in abrading, the protection of skin superficial wound surface such as incised wound.
The specific embodiment
Below principle of the present invention and feature are described, institute only gives an actual example and to be used for explaining the present invention, is not for restriction scope of the present invention.
Embodiment 1: accurately take by weighing dehydrated alcohol 768 grams and put in the beaker, add 60 gram ethyl acetate, add 12 gram tributyl 2-acetylcitrates, 30 gram isopropyl palmitates, 10 gram vitamin e acetates after stirring successively, stir, make into the stable homogeneous clear solution.In this solution, add 120 gram nitrocelluloses, continue stirring until dissolving fully.Filter, fill is finished product.
Embodiment 2: the amount of dehydrated alcohol in the specific embodiment 1 is adjusted into 778 grams, and the amount of ethyl acetate is adjusted into 50 grams, and all the other are with specific embodiment 1.
Embodiment 3: the amount of dehydrated alcohol in the specific embodiment 1 is adjusted into 762 grams, and the amount of tributyl 2-acetylcitrate is adjusted into 15 grams, and nitrocellulosic amount is adjusted into 150 grams, and all the other are with specific embodiment 1.
Liquid binder of the present invention cleans wound site in use earlier, treat the wound site drying after, the liquid binder is directly spread upon wound site, the liquid binder will be in one minute the natural drying film forming, wound surface is played protective action.
The biological property indexs such as microbial limit, cytotoxicity, sensitization, intradermoreaction of liquid binder of the present invention by the control product is to guarantee the clinical use safety of product; By content of beary metal and the pH value 6.0～8.0 of control product, to guarantee product patient's wound and skin are not produced stimulation or toxicity; By moisture-vapor transmission, water preventing ability, the resistance bacterium property after the control product film forming, to guarantee that product is to the protection effect of patient's wound surface.The vitamin e acetate that uses in the product of the present invention have delay cell senescence, prevent blood coagulation, the effect of acceleration of tissue repair, minimizing cicatrization, it has the effect of good promotion healing to skin superficial wound surface such as scratch, incised wounds.The effect that product of the present invention has after film forming is ventilative, blocked water, hindered bacterium plays natural cover for defense effect to wound infection.
By check, more than the experimental result of three embodiment as follows:
| ? | Viscosity of sludge | Film formation time | Guard time | Moisture-vapor transmission |
| Embodiment 1 | 630mPa·s | 50s | ≥48h | ≥300g·m -2·24h -1 |
| Embodiment 2 | 600mPa·s | 45s | ≥48h | ≥300g·m -2·24h -1 |
| Embodiment 3 | 850mPa·s | 60s | ≥48h | ≥300g·m -2·24h -1 |
Liquid binder of the present invention has following beneficial effect: 1, film formation time is short, and guard time is long; 2, the characteristic that has waterproof and breathable does not influence orthobiosis; 3, can promote wound healing effectively, reduce the formation of cicatrix; 4, effectively stop antibacterial to the intrusion of wound face, protect from infection; 5, have comfortableness, simple and practical, have no side effect; 6, area coverage is changeable, and irregular wound surface is also had good protective; 7, transparent material is convenient to observe the wound healing situation; 8, specious generous.
Macromolecule filming material in the liquid binder of the present invention is chosen to be nitrocellulose, does not still have in the similar competing product of Xiao Shouing at home and duplicates, and other adds the nontoxic plasticizer tributyl 2-acetylcitrate and improves filming performance, makes it soft more comfortable; Organic solvent is chosen to be dehydrated alcohol and ethyl acetate, and it is as the most frequently used organic solvent, and other the organic solvent of comparing is lower to human body and environmental hazard, also more environmental protection; Functional material is chosen to be vitamin e acetate, and it can better enhance metabolism as the nutritional labeling of needed by human, avoids cellular oxidation aging, reduces the formation of cicatrix.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. wound surface protection liquid binder with water proofing property, it is characterized in that, described liquid binder comprises dehydrated alcohol, ethyl acetate, nitrocellulose, tributyl 2-acetylcitrate, isopropyl palmitate and vitamin e acetate, in the liquid binder of 100 grams, comprise the dehydrated alcohol of 60 grams～90 grams, the ethyl acetate of 1 gram～10 grams, the nitrocellulose of 5 grams～15 grams, the tributyl 2-acetylcitrate of 0.5 gram～2 grams, the isopropyl palmitate of 1 gram～5 grams and the vitamin e acetate of 0.1 gram～2 grams.
2. the liquid binder is used in the wound surface protection with water proofing property according to claim 1, it is characterized in that the pH value of described liquid binder is 6.0～8.0.
3. the wound surface with water proofing property protects the preparation method of using the liquid binder, it is characterized in that described preparation method may further comprise the steps:
1) dehydrated alcohol and ethyl acetate are mixed the uniform mixed liquor of formation, wherein, to prepare the liquid binders of 100 grams, the amount of dehydrated alcohol is 60 grams～90 grams, and the amount of ethyl acetate is that 1 gram～10 restrains;
2) in mixed liquor, add tributyl 2-acetylcitrate, isopropyl palmitate and vitamin e acetate and stir successively, form transparent and homogeneous solution, wherein, to prepare the liquid binder of 100 grams, the amount of tributyl 2-acetylcitrate is 0.5 gram～2 grams, the amount of isopropyl palmitate is 1 gram～5 grams, and the amount of vitamin e acetate is 0.1 gram～2 grams;
3) add nitrocellulose and stir and make its dissolving in transparent and homogeneous solution, wherein, to prepare the liquid binders of 100 grams, nitrocellulosic amount is 5 grams～15 grams;
4) will be dissolved with nitrocellulosic solution and filter, the insoluble impurity and the fiber filter that contain in the nitrocellulose solution are removed, and carry out fill again and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010584845 CN102058900B (en) | 2010-12-13 | 2010-12-13 | Waterproof liquid bandage for wound surface protection and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010584845 CN102058900B (en) | 2010-12-13 | 2010-12-13 | Waterproof liquid bandage for wound surface protection and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102058900A CN102058900A (en) | 2011-05-18 |
| CN102058900B true CN102058900B (en) | 2013-09-04 |
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| CN 201010584845 Active CN102058900B (en) | 2010-12-13 | 2010-12-13 | Waterproof liquid bandage for wound surface protection and preparation method thereof |
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| CN104814982B (en) * | 2015-04-21 | 2019-07-19 | 华侨大学 | A kind of Chinese medicinal liquor bandage and preparation method |
| CN104825273A (en) * | 2015-05-30 | 2015-08-12 | 李孟平 | Method for preparing breathable self-adhesion elastic bandage |
| CN105288722A (en) * | 2015-11-13 | 2016-02-03 | 任宏 | Waterproof ventilating liquid adhesive bandage and preparation method thereof |
| CN105434404B (en) * | 2015-12-18 | 2018-07-17 | 江苏海智生物医药有限公司 | A kind of plastics for protecting wound surface |
| CN105688254A (en) * | 2016-03-08 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Breathable medical bandage and preparation method thereof |
| JP6775976B2 (en) * | 2016-03-18 | 2020-10-28 | 小林製薬株式会社 | Topical preparation for reducing skin friction |
| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
| CN107693840A (en) * | 2016-08-09 | 2018-02-16 | 北京纳通医学科技研究院有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN106367869B (en) * | 2016-08-26 | 2018-07-31 | 安徽省康富医疗用品有限公司 | A kind of preparation method of the non-latex high-elasticity bandage of water proofing property |
| CN108939145A (en) * | 2018-08-13 | 2018-12-07 | 西安中天生物医药有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN108785739A (en) * | 2018-08-13 | 2018-11-13 | 中国人民解放军南京军区福州总医院 | A kind of full-service fluid adhesive bandage and preparation method thereof |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
| CN110201220A (en) * | 2019-05-29 | 2019-09-06 | 利安隆博华（天津）医药化学有限公司 | A kind of liquid adhesive bandage and preparation method thereof improving osmotic absorption rate |
| CN110101900A (en) * | 2019-06-20 | 2019-08-09 | 江西高大生物医疗科技有限公司 | A kind of film forming agent of the insulation blocking surface of a wound |
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|---|---|---|---|---|
| US3966483A (en) * | 1975-03-24 | 1976-06-29 | Carpenter Chemical Company | Method of formulating solution containing dispersed nitrocellulose |
| US5763412A (en) * | 1997-04-08 | 1998-06-09 | Becton Dickinson And Company | Film-forming composition containing chlorhexidine gluconate |
| CN1399565A (en) * | 1999-11-23 | 2003-02-26 | 永动力控股公司 | Propellant free spray-on skin patch composition for improving wound healing and for drug administration |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030118655A1 (en) * | 2001-12-21 | 2003-06-26 | Nikhil Kundel | Film forming liquid composition |
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2010
- 2010-12-13 CN CN 201010584845 patent/CN102058900B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966483A (en) * | 1975-03-24 | 1976-06-29 | Carpenter Chemical Company | Method of formulating solution containing dispersed nitrocellulose |
| US5763412A (en) * | 1997-04-08 | 1998-06-09 | Becton Dickinson And Company | Film-forming composition containing chlorhexidine gluconate |
| CN1399565A (en) * | 1999-11-23 | 2003-02-26 | 永动力控股公司 | Propellant free spray-on skin patch composition for improving wound healing and for drug administration |
| US7198800B1 (en) * | 1999-11-23 | 2007-04-03 | Thomas Sai Ying Ko | Compositions and methods |
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| CN102058900A (en) | 2011-05-18 |
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Owner name: SHANDONG YINUO BIOLOGICAL SCIENCE + TECHNOLOGY CO. Free format text: FORMER OWNER: DOU BENLI Effective date: 20140701 |
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Free format text: CORRECT: ADDRESS; FROM: 264670 YANTAI, SHANDONG PROVINCE TO: 265600 BINZHOU, SHANDONG PROVINCE |
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Effective date of registration: 20140701 Address after: 265600, Shandong Binzhou County, Boxing Metro two northbound head Patentee after: Shandong Yinuo Biological Technology Co., Ltd. Address before: 264670, No. four, No. 25, Yantai hi tech Industrial Park, Shandong, Yantai, China Patentee before: Du Benli |