CN102160829A - Novel bio-absorbable bracket for slide fastener - Google Patents
Novel bio-absorbable bracket for slide fastener Download PDFInfo
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- CN102160829A CN102160829A CN201010111299XA CN201010111299A CN102160829A CN 102160829 A CN102160829 A CN 102160829A CN 201010111299X A CN201010111299X A CN 201010111299XA CN 201010111299 A CN201010111299 A CN 201010111299A CN 102160829 A CN102160829 A CN 102160829A
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Abstract
The invention provides a novel bio-absorbable bracket for a slide fastener. The bracket is in a sheet shape before being implanted and comprises a bracket body, a bracket head and a bracket fastener, wherein the bracket body is in a mesh structure, and the bracket head plays a role of a slide fastener. According to different positions of the slide fastener, the bracket is divided into a fastener inserting type bracket, an edge slide fastener type bracket and a middle slide fastener type bracket. In the fastener inserting type bracket, several small fasteners are arranged in a bracket head frame, and a bracket body is in a mesh shape; in the edge slide fastener type bracket, the inside of a bracket head frame is not provided with fasteners, and a plurality of small fasteners facing the same direction are arranged at two sides of a bracket body in a mesh shape; and in the middle slide fastener type bracket, a small fastener is arranged in the middle in a bracket head, and a bracket body corresponding to the fastener is provided with a plurality of small fasteners facing the same direction. With the expansion of a balloon, the bracket slides and expands, and after the balloon is removed, the bracket is immediately fastened to support blood vessels.
Description
Technical field
The present invention relates generally to medical instruments field, more specifically say, the present invention relates to a kind of novel slide fastener biology and can absorb support, be mainly used in blood vessel dilating, also can be used for the narrow positions of organs such as trachea, esophagus, urethra, biliary tract.
Background technology
Congenital heart disease is a modal cardiovascular disease in children's's period, sickness rate is life birth baby's 0.678%, with congenital pulmonary artery and pulmonary venous stenosis, vena systemica and aorta and the ramose narrow 7%-15% that accounts for all congenital heart diseases thereof, and acquired surgical postoperative right ventricle-pulmonary artery artificial nest (RV-PA pipeline) is narrow, the patient's such as narrow of pulmonary artery and pulmonary vein postoperative restenosis, vena systemica and aorta and ramose restenosis and Fontan passage quantity is along with the increase of congenital heart disease operation ability will continue to rise in the infant congenital heart disease.But such pathological changes is extremely thorny at the commonly used treatment means of infantile period such as percutaneous balloon dilatation or open chest surgery treatment in clinical.The technical difficulty that the right ventricular outflow that the infant congenital heart disease often merges and the surgical intervention of PBS are rebuild more tiny pulmonary artery is bigger, be prone to postoperative residue and block and cause recent operation again, and the restenosis rate in 5 years can be up to 50-60%.Though percutaneous puncture balloon expandable urethroptasty can have certain effect, restenosis rate still can be up to 40%, and for because buckling of vessel or because the narrow and restenosis effect due to the external force pressure is often undesirable.Current research shows that Stent is the ideal selection of such lesions treatment.
Intravascular stent commonly used at present etc. is metal knitted forming.The supporting role of playing in early days after support is implanted blood vessel wall prevents retraction, and along with the endothelialization of support and the reconstruct of later stage blood vessel wall, in fact support only need play interim supporting role.But fixed size that metal rack is implanted the back can not change with angiogenic growth, the later stage easily causes with blood vessel size do not match cause artificial narrow.Also there is following defective in metal rack: (1) easily needs long-term Antiplatelet therapy to thrombosis; (2) be stranded in all the life in the human body, influence follow-up possible surgical operation therapy; (3) pseudo-shadow appears when nuclear magnetic resonance, NMR and CT examination.So biology can absorb support prospect will be arranged most.
Can absorb the used material of support for biology, research at present is mainly Poly-L-lactic acid, also has poly-to oxygen Ketohexamethylene and polycaprolactone.These materials are degraded gradually in vivo, participates in excreting behind the internal metabolism; Can implant by drugs approved by FDA.Can absorb at biology has the Igaki-Tamai support in the design of support: adopt to be the Zig-Zag shaped design; The REVA support: entire bracket has a kind of slide ﹠amp; The lock structural design; Four impeller structure supports: it is based on four impeller structures that fiber is made, and coil continues around going out the entire bracket health, expands fully when coming when support, just is the structure that a spiral winding adds three longitudinal fibers.These support common features are for to be a complete column type before expansion, but equal existing problems, promptly the rack elasticity retraction easily takes place in the support force deficiency of all supports.
Summary of the invention
The objective of the invention is bottleneck, and biology can absorb the hypodynamic problem of stent support at present infant angiostenosis pathological changes interventional therapy method; Provide a kind of new bio can absorb support, not only have the stent support of raising power and have diverse novel slide fastener design outline simultaneously.
The invention provides a kind of novel slide fastener biology and can absorb support, be one laminar before support is implanted, comprise mesh-structured rack body, be arranged in rack body one end and play the support head of slide fastener effect and rack body is fixed into piped support and buckle at the support curly course.According to the difference of support button present position, be divided into eye-splice type, edge slide fastener type and three kinds of shapes of middle slide fastener type.
As shown in Figure 1, the biology that has shown one embodiment of the present invention can absorb the slide fastener support.This support comprises: the rack body of flat, the support head that is positioned at body one end and support button.The rack body several rows of mesh that distributing on partly, each mesh size can be identical or different.In an embodiment of the invention, each mesh size is equally distributed, and for example, the mesh size is 0.5-3mm.Mesh can be an Any shape, comprises circle, ellipse, square, rectangle, triangle, polygon etc.In an embodiment of the invention, mesh is circular.The support button bit as shown in Figure 1, comprises 2-4 outstanding button near the support head, the button of these projections constitutes slide fastener device of the present invention with housing.The button that also can have more a plurality of projections, this depends primarily on the size of required support and required application.The length of the button of projection is 0.5-1mm, and is angled with respect to the support plane, is generally the 20-40 degree.But it will be understood by those skilled in the art that it also can is any other angle.The size of housing and rack body size adapt, thereby guarantee that in the support curly course inner projection button can strictly slide along the sheet length direction, avoids misplacing.The button of described projection can be inserted into arbitrarily in the process of sliding in the middle of any row's mesh, and makes thin slice can fixedly become tubulose.
As shown in Figure 2, the biology that has shown another embodiment of the present invention can absorb the slide fastener support.This support comprises the rack body of flat, the support head that is positioned at body one end and support button.Support comprises longitudinal axis Z that is parallel to the extension of support head and the transversal line X that extends perpendicular to the support head, as shown in the figure.The rack body several rows of mesh that distributing on partly, each mesh size can be identical or different.In an embodiment of the invention, each mesh size is equally distributed, and for example, the mesh size is 0.5-3mm.Mesh can be an Any shape, comprises circle, ellipse, square, rectangle, triangle, polygon etc.In an embodiment of the invention, mesh is circular.The support head comprises a housing, and its size adapts with rack body.In the accompanying drawing illustrated embodiment, the support button shows as the tooth of rack body both sides, can pass described housing at rack body described in the support curly course, and the toothing on both sides can slide along the two edges of described housing.In the process of sliding, described tooth fastens described housing, and makes thin slice can fixedly become tubulose.In one embodiment, the size of tooth is 0.1mm.All teeth are support head extension dorsad all, and are angled with respect to the support transversal line, for example the 30-60 degree.In an embodiment of the invention, tooth becomes 30 degree angles with respect to the support transversal line.
As shown in Figure 3, the biology that has shown the another embodiment of the present invention can absorb the slide fastener support.This support comprises the rack body of flat, the support head that is positioned at body one end and support button.As shown in the figure, support comprises longitudinal axis Z that is parallel to the extension of support head and the transversal line X that extends perpendicular to the support head.The rack body several rows of mesh that distributing on partly, each mesh size can be identical or different.In an embodiment of the invention, each mesh size is equally distributed, and for example, the mesh size is 0.5-3mm.Mesh can be an Any shape, comprises circle, ellipse, square, rectangle, triangle, polygon etc.In an embodiment of the invention, mesh is circular.The support head comprises a housing and the intermediary buckle structure of housing, and the button two ends all are connected with housing.In one embodiment, the length 0.5-1mm of buckle structure.Comprise in the rack body and the corresponding tooth of buckle structure that these teeth extend back on the support head.In one embodiment, the size of tooth is 0.1mm.Described tooth is angled with respect to the support transversal line, for example becomes 30-60 degree angle.In an embodiment of the invention, tooth becomes 30 degree angles with respect to the support transversal line.In the support curly course, slide in the both sides of the buckle structure of described toothing in the support head housing, and in the process of sliding, described tooth fastens the buckle structure in the described housing, and makes thin slice can fixedly become tubulose.
In Fig. 2 and embodiment shown in Figure 3, because all teeth all in the same direction, promptly can not bounce back after support fastens again.In the process of sending in body, support is tightly rolled and is attached on the delivery apparatus sacculus, arrives after the appointed part, balloon expandable makes support slip enlarged-diameter, the resorption sacculus fastens immediately owing to be subjected to the pressure arm of blood vessel wall, and blood vessel wall is played a supportive role.
Biology can absorb the new polymer that the support material therefor comprises that polylactic acid (PLA), PPDO (PDO), poly-own lactone (PCL), polyglycolic acid (PGA), poly butyric high molecular polymers such as (PHB) and different polymer copolymerization, blend, modification etc. are generated etc.Degradation material at implant into body, finish the mechanical support effect after, can be degraded into the micromolecule safe and harmless to human body, excrete.The making of support comprises die pressing, machine impact system, laser engraving method or the like.
Different with the biological absorbable stent of present research is unique slide fastener project organization.Other biological can absorb support and is cylindric before expansion, is a lamellar structure and slide fastener type biology can absorb blood vessel; Almost do not have elastical retraction after the support expansion, obviously improve support radial support power.
Different with the conventional metals intravascular stent is that biological absorbable stent of the present invention has completely new concept.At first metal rack is cylindric before expansion, is a lamellar structure and slide fastener type biology can absorb blood vessel; Elastical retraction is in various degree all arranged after the metal rack expansion, and this support radial support power is strong, does not almost have elastical retraction.Present clinical metal rack will not be for separating material, defective: (1) easily needs long-term Antiplatelet therapy to thrombosis; (2) be stranded in all the life in the human body, influence follow-up possible surgical operation therapy; (3) pseudo-shadow appears when nuclear magnetic resonance, NMR and CT examination.Because it is absorbable material that biology can absorb support, all there are not the problems referred to above, stenotic lesions such as the coronary artery that can be applied to be grown up, renal artery, ventral aorta, thoracic aorta, carotid artery not only can solve simultaneously the interventional therapy of this special defects disease of infant angiostenosis.Also can be used for being grown up and the treatment of the narrow positions of organs such as child's trachea, esophagus, urethra, biliary tract.
Description of drawings
Fig. 1 is the sketch map of the slide fastener support of one embodiment of the present invention.
Fig. 2 is the sketch map of the slide fastener support of one embodiment of the present invention.
Fig. 3 is the sketch map of the slide fastener support of one embodiment of the present invention.
Fig. 4 is the radiography figure before slide fastener support of the present invention is implanted.
Fig. 5 is the radiography figure after slide fastener support of the present invention is implanted.
The instantiation mode
Embodiment 1: observe the in-vitro simulated release conditions of polycaprolactone (PCL) eye-splice type support.
One, materials and methods:
Material: each 10 of polycaprolactone (PCL) snap-type support 20*8mm, diameter 6cm band tubing, stent delivery system and compression pump.
Method:
1, earlier the sacculus of delivery system is inhaled into negative pressure with compression pump, recession epitheca pipe, the slide fastener support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.
2, along seal wire stent delivery system is inserted into the artificial blood vessel target site, 12atm*30 expands and discharge support second.
3, the resorption sacculus becomes negative pressure, the recession sacculus.
Two, observation index:
1, lumen of vessels diameter: after sacculus is removed, measurement bracket place lumen of vessels interior diameter.
2, acute elastic relaxation shrinkage:
Support acute elastic relaxation shrinkage=(diameter-sacculus was removed the after-poppet diameter when support was fully expanded)/diameter when support is fully expanded.
3, successfully fasten rate:
Evaluation criterion: success: remove sacculus after-poppet button and block immediately; Failure: remove the sacculus after-poppet and do not fasten, sliding in tube chamber.
Three, result:
PCL eye-splice type support all can discharge (10-14atm) under conventional release pressure, support all can successfully fasten, and does not have support to curl in tube chamber; Support is kept predefined lumen diameter substantially, has extremely low acute elastic relaxation shrinkage (0.4%).Prove this support Design operation feasible.
The result of table 1:PCL eye-splice type support
| n | Release pressure (atm) | Support place lumen diameter (mm) | Acute elastic relaxation shrinkage (%) | Fasten rate (%) | |
| Snap-type | 10 | 12±2 | 7.8±0.2 | 0.4±0.1 | 100 |
Embodiment 2: observe the in-vitro simulated release conditions of polycaprolactone (PCL) edge slide fastener type support
One, materials and methods:
Material: each 10 of polycaprolactone (PCL) edge slide fastener type support 20*8mm, diameter 6cm band tubing, stent delivery system and compression pump.
Method:
1, earlier the sacculus of delivery system is inhaled into negative pressure with compression pump, recession epitheca pipe, support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.
2, along seal wire stent delivery system is inserted into the artificial blood vessel target site, 12atm*30 expands and discharge support second.
3, the resorption sacculus becomes negative pressure, the recession sacculus.
Two, observation index:
1, lumen of vessels diameter: after sacculus is removed, measurement bracket place lumen of vessels interior diameter.
2, acute elastic relaxation shrinkage:
Support acute elastic relaxation shrinkage=(diameter-sacculus was removed the after-poppet diameter when support was fully expanded)/diameter when support is fully expanded.
3, successfully fasten rate:
Evaluation criterion: success: remove sacculus after-poppet button and block immediately; Failure: remove the sacculus after-poppet and do not fasten, sliding in tube chamber.
Three, result:
PCL edge slide fastener type support all can discharge (11-15atm) under conventional release pressure, support all can successfully fasten, and does not have support to curl in tube chamber; Support is kept predefined lumen diameter substantially, has extremely low acute elastic relaxation shrinkage (0.35%).Prove this support Design operation feasible.
The result of table 2:PCL edge slide fastener type support
| n | Release pressure (atm) | Support place lumen diameter (mm) | Acute elastic relaxation shrinkage (%) | Fasten rate (%) |
| Edge slide fastener type | 10 | 13±2 | 7.82±0.2 | 0.35±0.1 | 100 |
Embodiment 3: observe the in-vitro simulated release conditions of the middle slide fastener type support of polycaprolactone (PCL)
One, materials and methods:
Material: each 10 of slide fastener type support 20*8mm, diameter 6cm band tubing, stent delivery system and compression pump in the middle of the polycaprolactone (PCL).
Method:
1, earlier the sacculus of delivery system is inhaled into negative pressure with compression pump, recession epitheca pipe, the slide fastener support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.
2, along seal wire stent delivery system is inserted into the artificial blood vessel target site, 12atm*30 expands and discharge support second.
3, the resorption sacculus becomes negative pressure, the recession sacculus.
Two, observation index:
1, lumen of vessels diameter: after sacculus is removed, measurement bracket place lumen of vessels interior diameter.
2, acute elastic relaxation shrinkage:
Support acute elastic relaxation shrinkage=(diameter-sacculus was removed the after-poppet diameter when support was fully expanded)/diameter when support is fully expanded.
3, successfully fasten rate:
Evaluation criterion: success: remove sacculus after-poppet button and block immediately; Failure: remove the sacculus after-poppet and do not fasten, sliding in tube chamber.
Three, result:
Slide fastener type support all can discharge (11-15atm) in the middle of the PCL under conventional release pressure, and support all can successfully fasten, and does not have support to curl in tube chamber; Support is kept predefined lumen diameter substantially, has extremely low acute elastic relaxation shrinkage (0.34%).Prove this support Design operation feasible.
The result of slide fastener type support in the middle of the table 3:PCL
| n | Release pressure (atm) | Support place lumen diameter (mm) | Acute elastic relaxation shrinkage (%) | Fasten rate (%) | |
| Middle slide fastener type | 10 | 13±2 | 7.86±0.2 | 0.34±0.1 | 100 |
Embodiment 4: observe the in-vitro simulated release conditions of PPDO (PDO) eye-splice type support
One, materials and methods:
Material: each 10 of PPDO (PDO) eye-splice type support 20*8mm, diameter 6cm band tubing, stent delivery system and compression pump.
Method:
1, earlier the sacculus of delivery system is inhaled into negative pressure with compression pump, recession epitheca pipe, the slide fastener support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.
2, along seal wire stent delivery system is inserted into the artificial blood vessel target site, 12atm*30 expands and discharge support second.
3, the resorption sacculus becomes negative pressure, the recession sacculus.
Two, observation index:
1, lumen of vessels diameter: after sacculus is removed, measurement bracket place lumen of vessels interior diameter.
2, acute elastic relaxation shrinkage:
Support acute elastic relaxation shrinkage=(diameter-sacculus was removed the after-poppet diameter when support was fully expanded)/diameter when support is fully expanded.
3, successfully fasten rate:
Evaluation criterion: success: remove sacculus after-poppet button and block immediately; Failure: remove the sacculus after-poppet and do not fasten, sliding in tube chamber.
Three, result:
PDO eye-splice type support all can discharge (10-14atm) under conventional release pressure, support all can successfully fasten, and does not have support to curl in tube chamber; Support is kept predefined lumen diameter substantially, has extremely low acute elastic relaxation shrinkage (0.5%).Prove this support Design operation feasible.
The result of table 4:PDO eye-splice type support
| n | Release pressure (atm) | Support place lumen diameter (mm) | Acute elastic relaxation shrinkage (%) | Fasten rate (%) | |
| Snap-type | 10 | 12±2 | 7.79±0.2 | 0.5±0.1 | 100 |
Embodiment 5: observe the in-vitro simulated release conditions of PPDO (PDO) edge slide fastener type support
One, materials and methods:
Material: each 10 of PPDO (PDO) edge slide fastener type support 20*8mm, diameter 6cm band tubing, stent delivery system and compression pump.
Method:
1, earlier the sacculus of delivery system is inhaled into negative pressure with compression pump, recession epitheca pipe, the slide fastener support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.
2, along seal wire stent delivery system is inserted into the artificial blood vessel target site, 12atm*30 expands and discharge support second.
3, the resorption sacculus becomes negative pressure, the recession sacculus.
Two, observation index:
1, lumen of vessels diameter: after sacculus is removed, measurement bracket place lumen of vessels interior diameter.
2, acute elastic relaxation shrinkage:
Support acute elastic relaxation shrinkage=(diameter-sacculus was removed the after-poppet diameter when support was fully expanded)/diameter when support is fully expanded.
3, successfully fasten rate:
Evaluation criterion: success: remove sacculus after-poppet button and block immediately; Failure: remove the sacculus after-poppet and do not fasten, sliding in tube chamber.
Three, result:
PDO edge slide fastener type support all can discharge (10-14atm) under conventional release pressure, support all can successfully fasten, and does not have support to curl in tube chamber; Support is kept predefined lumen diameter substantially, has extremely low acute elastic relaxation shrinkage (0.3%).Prove this support Design operation feasible.
The result of table 5:PDO edge slide fastener type support
| n | Release pressure (atm) | Support place lumen diameter (mm) | Acute elastic relaxation shrinkage (%) | Fasten rate (%) | |
| Edge slide fastener type | 10 | 12±2 | 7.82±0.2 | 0.3±0.1 | 100 |
Embodiment 6: observe the in-vitro simulated release conditions of the middle slide fastener type support of PPDO (PDO)
One, materials and methods:
Material: each 10 of slide fastener type type support 20*8mm, diameter 6cm band tubing, stent delivery system and compression pump in the middle of the PPDO (PDO).
Method:
1, earlier the sacculus of delivery system is inhaled into negative pressure with compression pump, recession epitheca pipe, the slide fastener support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.
2, along seal wire stent delivery system is inserted into the artificial blood vessel target site, 12atm*30 expands and discharge support second.
3, the resorption sacculus becomes negative pressure, the recession sacculus.
Two, observation index:
1, lumen of vessels diameter: after sacculus is removed, measurement bracket place lumen of vessels interior diameter.
2, acute elastic relaxation shrinkage: support acute elastic relaxation shrinkage=(diameter-sacculus was removed the after-poppet diameter when support was fully expanded)/diameter when support is fully expanded.
3, successfully fasten rate:
Evaluation criterion: success: remove sacculus after-poppet button and block immediately; Failure: remove the sacculus after-poppet and do not fasten, sliding in tube chamber.
Three, result:
Slide fastener type support all can discharge (10-16atm) in the middle of the PDO under conventional release pressure, and support all can successfully fasten, and does not have support to curl in tube chamber; Support is kept predefined lumen diameter substantially, has extremely low acute elastic relaxation shrinkage (0.43%).Prove this support Design operation feasible.
The result of slide fastener type support in the middle of the table 6:PDO
| n | Release pressure (atm) | Support place lumen diameter (mm) | Acute elastic relaxation shrinkage (%) | Fasten rate (%) | |
| Middle slide fastener type | 10 | 13±3 | 7.83±0.2 | 0.43±0.1 | 100 |
Embodiment 7
With PPDO (PDO) edge slide fastener type support, the pig iliac artery is carried out support implant, to observe its curative effect situation.
One, materials and methods
Material: 15 of 25Kg pigs, puncture needle, seal wire, 9F sheath pipe, Omnipaque, chlorine peace ketone, heparin, stent delivery system, compression pump and GE-2005 angiographic apparatus.
Sample content: 15 of pigs, PDO slide fastener support 20*6mm20.
The concrete steps method:
1, chlorine peace ketone 10mg/Kg anaesthetizes pig, tracheal intubation, and cardiac monitoring, the general aseptic towel of routine disinfection, the puncture left carotid artery is inserted 9F sheath pipe.
2, carry out left and right sides iliac artery angiography, select implantable intravascular, require stent diameter bigger by 25% than blood vessel diameter.
3, with compression pump the sacculus of delivery system is inhaled into negative pressure, recession epitheca pipe, the slide fastener support curled respectively to be wound on the delivery system sacculus, push forward again the epitheca pipe to bullet to encase support.Along seal wire stent delivery system is inserted into target site, 12-15atm*30 expands and discharge support second.Heparin 100U/Kg in the art.
4, the resorption sacculus becomes negative pressure, and the recession sacculus carries out angiography once more.
Two, observation index:
1, acute elastic relaxation shrinkage: (stent diameter when sacculus is fully expanded-postoperative radiography stent diameter)/stent diameter when sacculus is fully expanded.
2, delivery system success delivery rate: success: support sent to target site place, support do not have come off, support is accurately located, support is fully expanded.
3, complication rate: comprise vascular tear, massive hemorrhage, support displacement, death.
4, implant the back blood vessel diameter.Measure with computer behind the radiography.
Three, result:
1, support is implanted situation: see Table 7
Table 7:PDO slide fastener support embedded material feature
| Variable | n(％) |
| Experiment pig | 15 |
| Body weight (Kg) | 25.17±1.82 |
| Female | 8(53.4) |
| Male | 7(46.7) |
| Left side iliac artery | 12(60) |
| Right iliac artery | 8(40) |
| Reference vessel diameter (mm) | 4.68±0.17 |
| Release pressure (atm) | 14.1±2.20 |
2, support curative effect: see Table 8
Table 8: novel slide fastener support curative effect
| Variable | n(％) |
| The acute elastic relaxation shrinkage | 0.37±0.12 |
| Complication rate | 1(5) |
| The delivery system success rate | 20(100) |
| Blood vessel diameter (mm) | 5.92±0.06 |
The PDO support does not almost have elastical retraction as can be seen from the table, shows stronger support force; Novel delivery system is the successful delivering stent of energy all; One routine angiorrhexis is arranged, and contrast agent leaks outside, but overall complication is low, and this support and delivery system design are feasible.
3, radiography figure before and after support is implanted:
Fig. 4 be before support is implanted to the radiography figure of pig iliac artery to determine the support implant site.Fig. 5 is the radiography figure after support is implanted.As shown in the figure, blood vessel wall is expanded by support, the support unobstructed blood vessel.
The patent that this paper addresses, patent application, publication and file are not to recognize that any above-mentioned file belongs to prior art, do not admit the interior perhaps date of these publications or file yet.
Can not break away from basic side of the present invention to above making improvements.Though described essential details of the present invention with reference to one or more specific embodiment, but those of ordinary skills should know and can make change to concrete disclosed these embodiments of the application, and these improvement and raising still belong to scope of the present invention and design.The invention that this paper illustrative is described can be implemented lacking under the concrete disclosed one or more elements of this paper.Therefore, for example, in each example of the present invention, term " comprises ", " basically by ... constitute " and " by ... constitute " in any can be in addition in two terms any alternative.Therefore, used term and statement be non-limiting term as describing, and with the equivalent form of value of described feature or their each several part, will be appreciated that in the scope of the invention not to have various improvement shown in not getting rid of.
Claims (9)
1. implantable laminar integrated slide fastener biological support, described support comprises:
Flat rack body, described rack body has mesh-structured;
Be positioned at the support head of described rack body one end, described support head and rack body are integrally formed, and its size adapts with described rack body, and described support head plays the slide fastener effect in the curly course of described support; With
The support button, described support button is also integrally formed with described rack body, is used at the curly course of described support support being fixed into piped support button.
2. slide fastener biological support as claimed in claim 1, it is characterized in that, described support head is outer box form, its size adapts with described body, described support button is near the projection form the described support head, allow described rack body to pass wherein at housing described in the described support curly course, and then described projection also can be inserted in the mesh along described rack body slip, and make thin slice fixedly become tubulose.
3. slide fastener biological support as claimed in claim 2 is characterized in that, the support button of projection form is angled with respect to the rack body plane near the described support head.
4. slide fastener biological support as claimed in claim 2 is characterized in that, described mesh uniform distribution.
5. slide fastener biological support as claimed in claim 1, it is characterized in that, described support head is outer box form, its size adapts with described rack body, and described support button is the tooth that is positioned at the rack body both sides, allows described rack body to pass wherein at housing described in the described support curly course, the tooth of described body both sides slides along the two edges of described housing, in the process of sliding, described tooth fastens described housing, and makes thin slice fixedly become tubulose.
6. slide fastener biological support as claimed in claim 5 is characterized in that, described tooth is towards extending back on described support head, and angled with respect to the transversal line of described rack body.
7. slide fastener biological support as claimed in claim 1, it is characterized in that, described support head comprises the button that links to each other with housing in housing and the described housing, described support button shows as the tooth of rack body both sides, described tooth is corresponding with the button in described housing and the housing, slide along the buckle structure in described support head housing and the housing at toothing described in the described support curly course, in the process of sliding, described tooth fastens the buckle structure in the described housing, and makes thin slice can fixedly become tubulose.
8. slide fastener biological support as claimed in claim 7 is characterized in that, described tooth is towards extending back on described support head and angled with respect to the transversal line of described rack body.
9. as each described slide fastener biological support among the claim 1-8, it is characterized in that described timbering material comprises: the new polymer that polylactic acid (PLA), PPDO (PDO), poly-own lactone (PCL), polyglycolic acid (PGA), poly butyric high molecular polymers such as (PHB) and different polymer copolymerization, blend, modification etc. are generated etc.
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| CN109512559A (en) * | 2017-12-11 | 2019-03-26 | 河南理工大学 | A kind of supersonic induced micro-embossing preparation method of Biodegradable tubular bracket |
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| CN109512559A (en) * | 2017-12-11 | 2019-03-26 | 河南理工大学 | A kind of supersonic induced micro-embossing preparation method of Biodegradable tubular bracket |
| CN109512559B (en) * | 2017-12-11 | 2021-05-28 | 河南理工大学 | Ultrasonic-induced micro-pressure printing preparation method for biodegradable tubular stent |
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Application publication date: 20110824 |