CN102205154A - Blood processing filter and blood filtering method adopting same - Google Patents
Blood processing filter and blood filtering method adopting same Download PDFInfo
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- CN102205154A CN102205154A CN2011100791574A CN201110079157A CN102205154A CN 102205154 A CN102205154 A CN 102205154A CN 2011100791574 A CN2011100791574 A CN 2011100791574A CN 201110079157 A CN201110079157 A CN 201110079157A CN 102205154 A CN102205154 A CN 102205154A
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Abstract
The invention provides a blood processing filter and a blood filtering method adopting the same. The blood processing filter includes the flexible container having an inlet and an outlet for blood and the sheet-like blood processing filter material which is arranged to separate the inside of the container into the inlet side and the outlet side, wherein the flexible container includes a container body for accommodating the blood processing filter material and an inlet side port which is fixed to the container body to form the inlet or outlet, the inlet side port has an inlet side main tube section connected to a conduit that transports the blood and a fixed part which communicates the inlet side main tube section into the container body and fixes the inlet side main tube section to the outer surface of the container body, and the axis of main tube section inclines relative to the tangent of the outer surface of the container body.
Description
Technical field
The present invention relates to a kind of blood treatment filter that is used for removing bad composition such as condensation product, leukocyte from blood.Relate to particularly that a kind of conduct removes from the whole blood preparation, erythrocyte preparation, platelet transfusion, blood plasma preparation etc. of blood transfusion usefulness that small condensation product, the leukocytic purpose of the reason that becomes side effect are used, precision and can disposable blood treatment filter, particularly relate to a kind of flexible filter that adopts resin material etc. as the material of container.
Background technology
The whole blood of gathering from the blood donor be separated into blood component preparations such as erythrocyte preparation, platelet transfusion, blood plasma preparation usually and store after transfuse blood.In addition, become the reason of various blood transfusion side effect owing to being included in small condensation product, leukocyte in these Blood Preparationses, therefore, adopt the method for before blood transfusion, transfusing blood again behind these bad compositions of removal or after also preserving behind these bad compositions of removal after the blood sampling, being used further to transfuse blood more.
Remove leukocytic method as being used for from Blood Preparations, the most generally utilize leukocyte to remove filter and come the processing blood preparation.Leukocyte is removed filter and is adopted following two kinds: identical or similar with the situation of the bag of the separation assembly that will be used to by the filter element that non-woven fabrics, porous plastid constitute to take a blood sample, flexible and steam impregnability excellent material are used for leukocyte removal filter container, flexible container; Or the leukocyte that will be filled in by the filter cell that non-woven fabrics, porous plastid constitute in the rigid container of Merlon etc. is removed filter.
Usually, when removing filter process blood with these leukocytes, the bag that will be connected with the blood entrance side of filter via conduit, Blood Preparations to be processed is housed is placed on than the position about the high 20cm to 100cm of filter, utilize action of gravity to make Blood Preparations pass through filter, the Blood Preparations after filtering is contained in via in conduit and the reclaiming bag that the blood outlet side of filter is connected.Leukocyte at flexible container is removed under the situation of filter, and the resistance owing to filter element in filtering process has produced the pressure loss, and the space of filter inlet side becomes malleation.Under the situation of the filter that is made of flexible container, because container is flexible, so container expands because of this malleation is balloon-like, and filter element is pushed to the outlet side container.
On the other hand, with blood in the conduit that outlet is connected owing to gravity falls, want to move to the bag of the blood position that places low 50～100cm usually, after being used to hold filtration than filter, therefore, become negative pressure on the contrary in the space between outlet side container and the filter element under this effect, demonstrate the tendency that flexible container and filter element closely contact.That is, filter element has hindered flowing of blood because of dual power closely contacts with the outlet side container.
In addition, closely contact with the outlet side container, also consider to adopt rigid container comparatively cheap, corresponding Merlon etc. in the time of can sterilizing with autoclave (autoclave) in order to prevent filter element.But, consider for the processing blood preparation and need sterilize installing integral body, filter element is being filled under the situation of above-mentioned rigid container the sterilization time that the impregnability of steam is relatively poor and needs are long.In addition, when implementing long autoclave sterilization, owing to can cause the deterioration etc. of anticoagulant for storage of whole blood, therefore after with filter sterilised, the operation of the complexity that need having connected bags of blood, loop etc. after, implement to sterilize etc.
Summary of the invention
Even the environment that problem of the present invention is to provide a kind of negative pressure that produces malleation that entrance side is arranged and outlet side when filtering also can easily make up to be difficult between flexible container and the blood treatment filtration members closely contact, can not hinder flowing of blood and be easy to guarantee blood treatment filter mobile uniformly and that can carry out the effective blood processing.
In having the blood treatment filter in the past of flexible container, be provided with port as the gateway of blood.Therefore, for example the blood flexible pipe by stretching and being connected with the port of outlet side can prevent that the outlet side container from closely contacting with filter element.But, under the situation of in the past blood treatment filter, for example adopt along the outstanding tangential port (tangential port) of tangential direction of the outer surface of flexible container, in this blood treatment filter, when when the direction that the outlet side container is left from filter element stretches, might cause the bending of conduit such as blood flexible pipe and make the stream obturation, have room for improvement.For the conduit of realizing preventing simultaneously being used for pumping blood and the stream between the port inaccessible with prevent that the outlet side container from contacting with the tight of filter element, the inventor has carried out wholwe-hearted research, the result has finished the present invention.
Promptly, the present invention relates to a kind of blood treatment filter, the flaky blood treatment filtration members that it comprises the flexible container of inlet with blood and outlet and is configured to this internal tank is separated into entrance side and outlet side, wherein, flexible container has the container body that is used for containment blood processing filtration members and is fixed on the container body and the beveled end oral area that forms inlet or export, the beveled end oral area has the person in charge portion that is connected with the conduit that is used for pumping blood and person in charge portion is connected with the inside of container body and person in charge portion is fixed on fixed part on the outer surface of container body, and the axis of person in charge portion is with respect to the tangential tilt of the outer surface of container body.
For example, container body is left mutually with the blood treatment filtration members and conduits such as blood flexible pipe are applied with under the situation of pulling force wanting, in this blood treatment filter, because the axis of person in charge portion that is connecting conduit is with respect to the tangential tilt of the outer surface of container body, therefore, conduit is difficult for bending and is difficult for causing the stream obturation.And, by person in charge portion is applied pulling force, container body is left mutually with the blood treatment filtration members.Thereby, adopt above-mentioned blood treatment filter, even when filtering, produce the malleation of entrance side and the negative pressure of outlet side arranged, also can easily make up and be difficult to the environment that closely contacts between flexible container and the blood treatment filtration members, can not hinder the mobile of blood and be easy to guarantee mobile uniformly, and, can carry out effective blood and handle.
And, also can make the beveled end oral area for forming the blood treatment filter of the entrance side port part that enters the mouth.
And, also can make the beveled end oral area for forming the blood treatment filter of the outlet side port part that exports.
And, also can make the beveled end oral area and be entrance side port part that forms inlet and the blood treatment filter that forms the outlet side port part of outlet.
In addition, the present invention relates to a kind of filter method that adopts the blood of blood treatment filter, this blood treatment filter comprises the flexible container of inlet with blood and outlet and is configured to this internal tank is separated into the flaky blood treatment filtration members of entrance side and outlet side, wherein, flexible container has and is used for containment blood and handles the container body of filtration members and be fixed on the container body and form the beveled end oral area of above-mentioned inlet or above-mentioned outlet, the beveled end oral area has piped person in charge portion and person in charge portion is connected with the inside of container body and person in charge portion is fixed on fixed part on the outer surface of container body, person in charge portion is tilted with respect to the outer surface of container body, and person in charge portion is applied pulling force and guarantees spatially to filter simultaneously between blood treatment filtration members and container body to the direction of leaving from the blood treatment filtration members.
In this filter method, owing to make the outer surface inclination of person in charge portion with respect to container body, therefore, the conduit that is connected with person in charge portion is difficult for bending and is difficult for causing the stream obturation.And, by person in charge portion is applied pulling force and guarantees that between blood treatment filtration members and container body ground, space filters to the direction of leaving from the blood treatment filtration members, can also easily make up and be difficult to the environment that closely contacts between flexible container and the blood treatment filtration members, can not hinder the mobile of blood and be easy to guarantee mobile uniformly, and, can carry out effective blood and handle.
Description of drawings
Fig. 1 is the vertical view of the blood treatment filter of the 1st embodiment of the present invention.
Fig. 2 is the longitudinal section along the II-II line of Fig. 1.
Fig. 3 is that expression uses the blood treatment filter of present embodiment to carry out the key diagram of section of the state of blood filtration.
Fig. 4 is that expression uses the blood treatment filter of comparative example to carry out the key diagram of section of the state of blood filtration.
Fig. 5 is the cutaway view that amplifies the entrance side port part of the blood treatment filter of representing the 2nd embodiment of the present invention.
Fig. 6 is the cutaway view that amplifies the outlet side port part of the blood treatment filter of representing the 2nd embodiment of the present invention.
The specific embodiment
Below, with reference to the description of drawings embodiments of the present invention.In addition, said blood comprises the Blood Preparations such as whole blood preparation, erythrocyte preparation, platelet transfusion, blood plasma preparation of the usefulness of transfusing blood in embodiment.In addition, the profile of blood treatment filter can adopt various forms such as rectangle, discoid, oval plate-like, ellipticity, but in order to reduce the spillage of material when making, is preferably rectangle, thereby, be that example describes in the following embodiments with the rectangle.
The blood treatment filter 1A of the 1st embodiment at first, is described with reference to Fig. 1 and Fig. 2.Blood treatment filter 1A has: flexible container 7, and it has the inlet 5 and the outlet 6 of blood; Flaky blood treatment filtration members 9, it is configured to the inside of flexible container 7 is divided into inlet 5 sides and outlet 6 sides.In the following description, be assumed to be under the 2nd planar situation at interior virtual plane at the center that will be the 1st plane along the hypothesis of plane mechanism of blood treatment filtration members 9, will comprise inlet 5 center and outlet 6, will be made as vertical Da along the direction of the 1st plane and the 2nd planar intersection, will and be made as horizontal Db with vertical Da quadrature and describe along the 1st planar direction.
In addition, the periphery of entrance side container 11 and outlet side container 12 bonds together mutually in the outside of inner seal portion 7a each other.The zonal bonding region that entrance side container 11 and outlet side container 12 directly bond together is outer seal 7b.Utilize entrance side container 11 and outlet side container 12 to be formed for the container body 10 that containment blood is handled filtration members 9.
On entrance side container 11, form the entrance side port part (beveled end oral area) 13 that is connected with the conduit 14A such as blood flexible pipe that are used for pumping blood.Entrance side port part 13 is configured to be partial to the end 10a side of vertical Da of container body 10.
Entrance side port part 13 has to be connected with conduit 14A and to receive the entrance side person in charge 13a of portion of blood and be used for that entrance side is responsible for the 13a of portion and is fixed on entrance side fixed part 13b on the entrance side container 11.Entrance side fixed part 13b is formed in the base part on the entrance side container 11, and the entrance side person in charge 13a of portion is set to crooked and outstanding with respect to entrance side fixed part 13b.
Front end at the entrance side person in charge 13a of portion is formed with inlet 5, is formed with for conduit 14A to embed and fixed connect apertures 20A on inlet 5.Be formed with and the inlet 5 inlet stream 13c that are connected in the inside of the entrance side person in charge 13a of portion.Inlet stream 13c is connected with the inside (filtration zone) of container body 10 via the intercommunicating pore 13d that is formed on the entrance side fixed part 13b.In addition, the entrance side port part 13 of present embodiment is formed on the entrance side container 11, utilizes welding etc. with they incorporate modes again but also can be formed into oral-lateral port part 13 and entrance side container 11 respectively by different members.
The axis La of the entrance side person in charge 13a of portion tilts with tiltangle a with respect to the tangent line Ta of the outer surface 11a of entrance side container 11.In addition, tiltangle a is 0 °＜θ a＜90 °, more preferably 30 °＜θ a＜90 °.In addition, tiltangle a is meant that vertically disposing under the situation of blood treatment filter 1A with the upside in modes last, outlet 6 side infra with 5 sides that enter the mouth be the angle that benchmark becomes narrow angle.
On outlet side container 12, form the outlet side port part (beveled end oral area) 15 that is useful on the outlet 6 that forms blood.The center that outlet side port part 15 is configured to container body 10 is that benchmark and entrance side port part 13 are point symmetry.
Outlet side port part 15 has to be connected with conduit 14B and to discharge the outlet side person in charge 15a of portion of blood and be used for that outlet side is responsible for the 15a of portion and is fixed on outlet side fixed part 15b on the outlet side container 12.Outlet side fixed part 15b is formed in the base part on the outlet side container 12, and the outlet side person in charge 15a of portion is set to crooked and outstanding with respect to outlet side fixed part 15b.
Front end at the outlet side person in charge 15a of portion is formed with outlet 6, is formed with for conduit 14B to embed and fixed connect apertures 20B in outlet 6.Be formed with and the outlet 6 outlet stream 15c that are connected in the inside of the outlet side person in charge 15a of portion.The base end side of the outlet side person in charge 15a of portion and outlet side fixed part 15b are connected, and outlet stream 15c is connected with the inside (filtration zone) of container body 10 via the intercommunicating pore 15d that is formed on the outlet side fixed part 15b.In addition, the outlet side port part 15 of present embodiment is formed on the outlet side container 12, utilizes welding etc. with they incorporate modes again but also can form oral-lateral port part 15 and outlet side container 12 respectively by different members.Optimizing oral-lateral port part 15 is molding product.And injection moulding more preferably.
The axis Lb of the outlet side person in charge 15a of portion tilts with tiltangle b with respect to the tangent line Tb of the outer surface 12a of outlet side container 12.In addition, tiltangle b is 0 °＜θ b＜90 °, more preferably 30 °＜θ b＜90 °.In addition, tiltangle b is meant that vertically disposing under the situation of blood treatment filter 1A with the downside in modes last, outlet 6 side infra with 5 sides that enter the mouth be the angle that benchmark becomes narrow angle.
As mentioned above, utilize entrance side container 11 and outlet side container 12 to be formed for the container body 10 that containment blood is handled filtration members 9.Container body 10 uses flexible resin(a) to make, and the plastic flat member of for example preferred use forms, and more preferably uses thermoplastic resin to form.The reason of using flat member be because: need make outer seal 7b along circumferentially be homogeneous thickness, and need make inner seal portion 7a along circumferential be homogeneous thickness.That is, be homogeneous thickness so long as outer seal 7b is homogeneous thickness and inner seal portion 7a, also can use membrane-like member to form container body 10, make container body 10 by the injection molding forming product.
The material of selling as sheet or film is used for the entrance side container 11 of present embodiment or the flexible resin(a) of outlet side container 12, so long as just can use on market.For example, as suitable material, can list the polyolefin as soft PVC, polyurethane, vinyl-vinyl acetate copolymer, polyethylene and polypropylene, the thermoplastic elastomer (TPE)s such as hydride, styrene-isoprene-styrene copolymer-or its hydride of s-B-S copolymer, and the mixture of softening agent such as thermoplastic elastomer (TPE) and polyolefin, ethylene-propylene acetoacetic ester etc.Owing to consider and the contacting of blood, therefore preferably as the material of medical treatment product such as bags of blood use, flexible vinyl chloride, polyurethane, Polyolefin and be with these thermoplastic elastomer (TPE)s as main component, flexible vinyl chloride more preferably.
In addition, entrance side container 11 can be all be made of the resin of hard, can a part be flexible resin(a) also.As long as the area more than 10% of the area of entrance side container 11 is a flexible container, the water vapo(u)r transmission during the autoclave sterilization will improve, and just can shorten sterilization time.
The blood treatment filtration members 9 of present embodiment, fibrous porous property medium, spongy texture thing etc. have the known filter mediums such as porous plastid of the continuous pore of three-dimensional mesh-shape can to use non-woven fabrics, weave cotton cloth etc., and the material of screen cloth (mesh), filter screen weldability differences such as (screen) is not suitable for.As the material that is suitable as blood treatment filtration members 9, polypropylene, polyethylene, s-B-S copolymer, polyurethane, polyester etc. have for example been enumerated.In blood treatment filtration members 9 is under the situation of non-woven fabrics, from the viewpoint of productivity ratio, preferred especially.
In addition, flaky blood treatment filtration members 9 can be a filter element, and can be formed by a plurality of filter elements.Under situation about forming by a plurality of filter elements, preferably by be configured in upstream (5 sides enter the mouth) be used to the downstream of removing the 1st filter element of small condensation product and being configured in the 1st filter element be used to remove leukocytic the 2nd filter element and constitute.For example, can be that the filtration members that constitutes of the non-woven fabrics of several～tens μ m is as the 1st filter element that is used to remove condensation product by fibre diameter in inlet 5 sides configuration, then configuration is that the filtration members that constitutes of the non-woven fabrics of 0.3～3.0 μ m is as being used to remove leukocytic the 2nd filter element, the stacked after-filter (postfilter) with particular space in the downstream again by fibre diameter.
1st, the 2nd filter element can further be made of various filter element respectively, and also only one of them filter element is made of various filter element. is for example; Can be (be that at least one of the nonwoven of 30～40 μ ms and nonwoven that fibre diameter be 10～20 μ ms consist of by fibre diameter) the 1st filter element that the nonwoven of 30～40 μ m and/or nonwoven that fibre diameter is 10～20 μ m consist of by fibre diameter in upstream side (entrance 5 sides) configuration, be (be that at least one of the nonwoven of 1.5～2.5 μ ms and nonwoven that fibre diameter be 0.5～1.8 μ m consist of by fibre diameter) the 2nd filter element that the nonwoven of 1.5～2.5 μ m and/or nonwoven that fibre diameter is 0.5～1.8 μ m consist of in the configuration of the downstream of the 1st filter element by fibre diameter. In addition, the non-woven fabrics that can alternate configurations crude fibre diameter and the non-woven fabrics of fine fibre diameter, but the non-woven fabrics of preferred crude fibre diameter is configured in upstream side (5 sides enter the mouth).
In addition, in order to form inner seal portion 7a, can use high frequency welding that blood treatment filtration members 9 and entrance side container 11 and outlet side container 12 are bonded together, welding entrance side container 11 and outlet side container 12 and blood treatment filtration members 9 in the lump also can welding entrance side containers 11 and blood treatment filtration members 9 and then welding blood treatment filtration members 9 and outlet side container 12.Promptly, order according to entrance side container 11, blood treatment filtration members 9, outlet side container 12 is configured, even input blood can be to system's external leakage yet, and, as long as become the structure of exporting after having passed through blood treatment filtration members 9, from the outlet 6 that is arranged on the outlet side container 12 99% or more from the blood (Blood Preparations) that is arranged on inlet 5 input on the entrance side container 11, container body 10 is not limited to welding with the adhering method of blood treatment filtration members 9, also can be additive method.
Then, with reference to Fig. 3 and Fig. 4 the filter method of use blood treatment filter 1A and the advantage of blood treatment filter 1A are described.Fig. 3 is that expression uses blood treatment filter 1A to carry out the key diagram of section of the state of blood filtration, and Fig. 4 is that expression uses the blood treatment filter of comparative example to carry out the key diagram of section of the state of blood filtration.
When using blood treatment filter 1A to carry out the filtration treatment of blood, the 1st bag that blood to be processed (Blood Preparations) will be housed is placed on than the position about the high 20cm to 100cm of blood treatment filter 1A, connects the 1st bag of inlet 5 sides with blood treatment filter 1A by conduit 14A.Under this state, blood treatment filter 1A becomes the state on the conduit 14A that is suspended on inlet 5 sides.And, because connecting the axis La of the entrance side person in charge 13a of portion of conduit 14A tilts with respect to the tangent line Ta of the outer surface 11a of entrance side container 11, therefore, be in the state that the entrance side person in charge 13a of portion is applied tensile force f a to the direction of leaving from blood treatment filtration members 9.
On the other hand, will be used to hold the 2nd bag of position that is placed on than the low 50～100cm of blood treatment filter 1A of the blood after the filtration, connect the 2nd bag of outlet 6 sides with blood treatment filter 1A by conduit 14B.Under this state, blood treatment filter 1A is in outlet 6 sides and is hanging the 2nd bag state by conduit 14B.And, because connecting the axis Lb of the outlet side person in charge 15a of portion of conduit 14B tilts with respect to the tangent line Tb of the outer surface 12a of outlet side container 12, therefore, along with the increase of the blood of in the 2nd bag, accumulating, become the state that the outlet side person in charge 15a of portion is applied tensile force f b to the direction of leaving from blood treatment filtration members 9.
After finishing, above-mentioned setting opens valve etc. and open stream, so filtration of beginning blood, because the effect of gravity, blood is from the 1st bag of inflow blood treatment filter 1A, and the blood after being filtered in blood treatment filter 1A flows into the 2nd bag from blood treatment filter 1A again.
At this, in inlet 5 sides of blood treatment filter 1A, owing to the resistance of blood treatment filtration members 9 sides has produced the pressure loss, the space S a of inlet 5 sides of flexible container 7 becomes malleation.Inlet 5 sides of flexible container 7 expand because of this malleation is balloon-like, and blood treatment filtration members 9 is pushed to outlet 6 sides.In addition, in outlet 6 sides of blood treatment filter 1A, owing to utilizing gravity to become negative pressure from exporting 6 sucking-off blood, thereby effect has the power of the narrow direction of the space S b stenosis that makes 9 of outlet side container 12 and blood treatment filtration members.
But inlet 5 sides at blood treatment filter 1A become the state that the entrance side person in charge 13a of portion is applied tensile force f a to the direction of leaving from blood treatment filtration members 9.Thereby, can reduce the power of pushing blood treatment filtration members 9 to outlet 6 sides, can guarantee between blood treatment filtration members 9 and container body 10 that ground, space filters.
In addition, outlet 6 sides at blood treatment filter 1A become the state that the outlet side person in charge 15a of portion is applied tensile force f b to the direction of leaving from blood treatment filtration members 9.Thereby, can energetically outlet side container 12 be drawn back from blood treatment filtration members 9, can guarantee between blood treatment filtration members 9 and container body 10 that space S b ground filters.
On the other hand, as shown in Figure 4, the blood treatment filter of comparative example (below be called " relatively filter ") 100 forms port one 01,102 as the gateway along tangent line Tk, the Tm of the outer surface 103a of container body 103.Thereby, even with the above-mentioned comparison filter 100 that similarly is provided with, the tensile force f k that is produced by the suspension of comparing filter 100 of entrance side also acts on along the last direction of the outer surface 103a of container body 103, and, outlet side by the 2nd bag suspension and the tensile force f m that produces also act on along the following direction of the outer surface 103a of container body 103.
The outer surface 103a of container body 103 and blood treatment filtration members 104 almost parallels that are contained in inside.Thereby, even directive effect has tensile force f k, Fm up and down, can not say in fact to making blood treatment filtration members 104 strong, can not prevent tight contact the between blood treatment filtration members 104 and the container body 103 with the directive effect that container body 103 leaves mutually.
In addition, want to make container body 103 when blood treatment filtration members 104 is left stretching conduit 14C, the 14D be connected with port one 01,102 by force, because tangent line Tk, Tw along container body 103 form port one 01,102, therefore all need howsoever to apply power to the direction that makes conduit 14C, 14D bending, thereby conduit 14C, 14D can be crushed and produce the stream obstruction.
For comparing filter 100, adopt blood treatment filter 1A, because connecting the axis La of the entrance side person in charge 13a of portion of conduit 14A tilts with respect to the tangent line Ta of the outer surface 11a of entrance side container 11, therefore, be difficult for applying power to the direction that makes conduit 14A bending, thereby, also be difficult for producing the stream obturation.In addition, the outlet side person in charge 15a of portion that is connecting conduit 14B is also identical, because the axis Lb of the outlet side person in charge 15a of portion is with respect to the tangent line Tb inclination of the outer surface 12a of outlet side container 12, therefore, be difficult for applying power to the direction that makes conduit 14B bending, thereby, also be difficult for producing the stream obturation.
Thereby, adopt the blood treatment filter 1A of present embodiment, even when filtering, produce malleation that inlet 5 sides are arranged and the negative pressure that exports 6 sides, also can easily make up and be difficult to the environment that closely contacts between flexible container 7 and the blood treatment filtration members 9, can not hinder the mobile of blood and be easy to guarantee mobile uniformly, and, can carry out effective blood and handle.In addition, in the blood treatment filter 1A of present embodiment, on entrance side and outlet side, formed the beveled end oral area, but only with entrance side and outlet side the two one of to be made as the beveled end oral area also passable.
The blood treatment filter 1B of the 2nd embodiment then, is described with reference to Fig. 5 and Fig. 6.In addition, about the blood treatment filter 1B of present embodiment, for blood treatment filter 1A components identical, the member of the 1st embodiment, mark identical Reference numeral and omit detailed explanation.In addition, the blood treatment filter 1B of present embodiment can use basically and make with the blood treatment filter 1A identical materials of the 1st embodiment.
As Fig. 5 and shown in Figure 6, entrance side port part (the beveled end oral area) 21 of the blood treatment filter 1B of the 2nd embodiment is different with the blood treatment filter 1A of the shape of outlet side port part (beveled end oral area) 23 and the 1st embodiment.
The entrance side port part 21 (with reference to Fig. 5) of present embodiment forms from entrance side container 11 outstanding with linearity, the root that combines with entrance side container 11 is divided into entrance side fixed part 21b, is the entrance side person in charge 21a of portion from the tubular portion in the outstanding outside of entrance side fixed part 21b.Front end at the entrance side person in charge 21a of portion is formed with inlet 5, is formed with for conduit 14A to embed and fixed connect apertures 20C on inlet 5.Be formed with the inlet stream 21c of the inside that is communicated with inlet 5 and container body 10 in the inside of the entrance side person in charge 21a of portion.
The axis Lc of the entrance side person in charge 21a of portion tilts with tiltangle c with respect to the tangent line Ta of the outer surface 11a of entrance side container 11.In addition, tiltangle c is 0 °＜θ c＜90 °, more preferably 30 °＜θ c＜90 °.In addition, tiltangle c is meant that vertically disposing under the situation of blood treatment filter 1B with the upside in modes last, outlet 6 side infra with 5 sides that enter the mouth be the angle that benchmark becomes narrow angle.
In addition, the entrance side port part 21 of present embodiment has the support shelves (spacer) 25 that are used for keeping with the tiltangle c of regulation the entrance side person in charge 21a of portion.Support shelves 25 for example are that section triangle, section are fan-shaped, the member of section tetragon (section rhombus, section parallelogram etc.), and being fixed on becomes the angle of tiltangle c side, thereby keep the entrance side person in charge 21a of portion with the tiltangle c of regulation.In addition, support shelves 25 also can be the such members in space that can form regulation in the angle side that becomes tiltangle c of the entrance side person in charge 21a of portion.
Outlet side port part 23 (with reference to Fig. 6) forms from outlet side container 12 outstanding with linearity, and the root that combines with outlet side container 12 is divided into outlet side fixed part 23b, is the outlet side person in charge 23a of portion from the tubular portion in the outstanding outside of outlet side fixed part 23b.Front end at the outlet side person in charge 23a of portion is formed with outlet 6, is formed with for conduit 14B to embed and fixed connect apertures 20D in outlet 6.Be formed with the outlet stream 23c of the inside that is communicated with outlet 6 and container body 10 in the inside of the outlet side person in charge 23a of portion.
The axis Ld of the outlet side person in charge 23a of portion tilts with tiltangle d with respect to the tangent line Tb of the outer surface 12a of outlet side container 12.In addition, tiltangle d is 0 °＜θ d＜90 °, more preferably 30 °＜θ d＜90 °.In addition, tiltangle d is meant that vertically disposing under the situation of blood treatment filter 1B with the downside in modes last, outlet 6 side infra with 5 sides that enter the mouth be the angle that benchmark becomes narrow angle.
In addition, the outlet side port part 23 of present embodiment has the support shelves 27 that are used for keeping with the tiltangle d of regulation the outlet side person in charge 23a of portion.Support shelves 27 for example are that section triangle, section are fan-shaped, the member of section tetragon (section rhombus, section parallelogram etc.), and being fixed on becomes the angle of tiltangle d side, thereby keep the outlet side person in charge 23a of portion with the tiltangle d of regulation.In addition, support shelves 27 also can be the such members in space that can form regulation in the angle side that becomes tiltangle d of the outlet side person in charge 23a of portion.
Adopt the blood treatment filter 1B of present embodiment, even when filtering, produce the malleation of entrance side and the negative pressure of outlet side arranged, also can easily make up and be difficult to the environment that closely contacts between flexible container 7 and the blood treatment filtration members 9, can not hinder the mobile of blood and be easy to guarantee mobile uniformly, and, can carry out effective blood and handle.
For example, blood treatment filter 1B is identical with the blood treatment filter 1A of the 1st embodiment, entrance side person in charge 21a of portion and the outlet side person in charge 23a of portion are tilted with respect to outer surface 11a, the 12a of container body 10, and, can apply pulling force and guarantee that between blood treatment filtration members 9 and container body 10 ground, space filters to the direction of leaving from blood treatment filtration members 9 entrance side person in charge 21a of portion and the outlet side person in charge 23a of portion.
By using support shelves 25,27, can constant cant angle (the θ c of Fig. 5 and the θ d of Fig. 6).Thereby the conduit 14A, the 14B that only are drawn into oral-lateral and outlet side merely just can easily create object space Sb.And, because improved the intensity of entrance side port part 21 or outlet side port part 23, so have the weld that prevents outer surface 11a, 12a and each port part 21,23 because of the damaged effect of stretching.
In addition, in the blood treatment filter 1B of present embodiment, on entrance side and outlet side, formed the beveled end oral area, but also can be only with entrance side and outlet side the two one of be made as the beveled end oral area.
Embodiment
Below, further describe the present invention by embodiment, but not being implemented example, the present invention do not limit.
The quantitative approach of the white blood cell count in the blood
Utilize flow cytometry inspection (flow cytometry) method to calculate leukocyte concentration in the blood.Use flow cytometer (FACSCalibur that BECTON DICKINSON company makes), use the Leucocount test kit (Japanese Becton Dickinsonand Company (ベ Network ト Application デ イ Star キ Application ソ Application) company) that contains pearl (PVC one ズ) that the white blood cell count among the blood 100 μ L of sampling is counted.
In addition, use following formula to obtain remaining white blood cell count.
The leukocyte concentration (individual/μ L) of remaining white blood cell count (individual)=filtration back blood * [(filtering recovery weight (g) ÷ 1.08 (filtering the proportion of back blood) of back blood) * 10
3]
Embodiment 1
Use has FlexRC filter (Asahi Medical Co's system, effectively the filter membrane area 42.2cm of entrance side port part and outlet side port part shown in Figure 2
2) filter erythrocyte preparation (white blood cell count: 9.6 * 10
9Individual) 320ml.Drop between bags of blood and the FlexRC filter (below be called the 1st embodiment filter) is made as 75cm.
With the stretch conduit that is connected with the 1st embodiment filter and fixing of the mode that can obtain the space S b among Fig. 3.θ a among Fig. 2 and the value of θ b are respectively 45 °.
Initial line speed is 0.21ml/ minute/cm
2, average linear velocity is 0.18ml/ minute/cm
2, final linear velocity is 0.15ml/ minute/cm
2Filtration time is 42.1 minutes, and the remaining white blood cell count in the erythrocyte preparation after the 1st embodiment filter filters is that 5.0 (log WBC) are individual.This shows,, can easily make up and be difficult to the environment (space) that closely contacts between flexible container and the blood treatment filtration members by adopting the beveled end oral area of the 1st embodiment of the present invention.Can not hinder the mobile of blood and guarantee and flow uniformly and can carry out effective blood and handle, the result compares with comparative example 1, has improved filtration time and leukocyte and has removed ability.
Embodiment 2
Except being made as respectively, the value with θ a among Fig. 2 and θ b carries out 1 identical operations 78 ° with embodiment.Below, this FlexRC filter is called the 2nd embodiment filter.
Initial line speed is 0.24ml/ minute/cm
2, average linear velocity is 0.20ml/ minute/cm
2, final linear velocity is 0.17ml/ minute/cm
2Filtration time is 37.9 minutes, and the remaining white blood cell count in the erythrocyte preparation after the 2nd embodiment filter filters is that 4.8 (log WBC) are individual.This shows,, can easily make up and be difficult to the environment (space) that closely contacts between flexible container and the blood treatment filtration members by adopting the beveled end oral area of the 2nd embodiment of the present invention.Can not hinder the mobile of blood and guarantee uniform flowing, and can carry out effective blood and handle, the result compares with comparative example 1, has improved filtration time and leukocyte and has removed ability.
Embodiment 3
Use has FlexRC filter (Asahi Medical Co's system, effectively the filter membrane area 42.2cm of entrance side port part shown in Figure 5 and outlet side port part shown in Figure 6
2) filter erythrocyte preparation (white blood cell count: 9.6 * 10
9Individual) 320ml.Drop between bags of blood and the FlexRC filter (below be called the 3rd embodiment filter) is made as 75cm.
With the stretch conduit that is connected with the 3rd embodiment filter and fixing of the mode that can obtain the space S b among Fig. 6.Use the support shelves to be set at θ c among Fig. 5 and the value of the θ d among Fig. 6 is respectively 30 °.
Initial line speed is 0.19ml/ minute/cm
2, average linear velocity is 0.17ml/ minute/cm
2, final linear velocity is 0.14ml/ minute/cm
2Filtration time is 44.6 minutes, and the remaining white blood cell count in the erythrocyte preparation after the 3rd embodiment filter filters is that 5.1 (log WBC) are individual.This shows,, can easily make up and be difficult to the environment (space) that closely contacts between flexible container and the blood treatment filtration members by adopting the beveled end oral area of the 3rd embodiment of the present invention.Can not hinder the mobile of blood and guarantee uniform flowing, and can carry out effective blood and handle, the result compares with comparative example 1, has improved filtration time and leukocyte and has removed ability.
Embodiment 4
Except being set at respectively, the value with θ c among Fig. 5 and the θ d among Fig. 6 carries out 3 identical operations 88 ° with embodiment.Below, this FlexRC filter is called the 4th embodiment filter.
Initial line speed is 0.26ml/ minute/cm
2, average linear velocity is 0.22ml/ minute/cm
2, final linear velocity is 0.18ml/ minute/cm
2Filtration time is 34.5 minutes, and the remaining white blood cell count in the erythrocyte preparation after the 4th embodiment filter filters is that 5.5 (log WBC) are individual.This shows,, can easily make up and be difficult to the environment (space) that closely contacts between flexible container and the blood treatment filtration members by adopting the beveled end oral area of the 4th embodiment of the present invention.Can not hinder the mobile of blood and guarantee uniform flowing, and can carry out effective blood and handle, the result compares with comparative example 1, has improved filtration time and leukocyte and has removed ability.
Comparative example 1
Use FlexRC filter (Asahi Medical Co's system, effectively filter membrane area 42.2cm
2) filter erythrocyte preparation (white blood cell count: 9.6 * 10
9Individual) 320ml.Drop between bags of blood and the FlexRC filter (below be called the 1st comparative example filter) is made as 75cm.Initial line speed is 0.18ml/ minute/cm
2, average linear velocity is 0.16ml/ minute/cm
2, final linear velocity is 0.14ml/ minute/cm
2Filtration time is 47.4 minutes, and the remaining white blood cell count in the erythrocyte preparation after the 1st comparative example filter filters is that 5.2 (log WBC) are individual.When filtering, entrance side is full of by blood and becomes barotropic state.In addition, when filtering, outlet side produces negative pressure, closely contacts between flexible container and the blood treatment filtration members.The structure of the 1st comparative example filter during filtration and state are as illustrated in Fig. 4.
Comparative example 2
Each conduit of stretching comparative example 1 (14C of Fig. 4 and 14D) and form the space at outlet side.But, this conduit bending as a result, blood can't flow.
Overall merit
Shown in above-mentioned embodiment, the filter of each embodiment of the present invention can obtain the space between blood treatment filtration members and outlet side container, therefore, can not hinder the mobile of blood and guarantee mobile uniformly, and can carry out effective blood handles, as a result, compare, improved filtration time and leukocyte and removed ability with comparative example.
Industrial applicibility
Blood processing filter of the present invention has industrial applicibility as the filter membrane of medical usage, medical application and general industry purposes.
Claims (5)
1. blood treatment filter, the flaky blood treatment filtration members that it comprises the flexible container of inlet with blood and outlet and is configured to this internal tank is separated into entrance side and outlet side is characterized in that,
Above-mentioned flexible container has the container body that is used to hold above-mentioned blood treatment filtration members and is fixed on the said vesse main body and forms the beveled end oral area of above-mentioned inlet or above-mentioned outlet,
Above-mentioned beveled end oral area has the person in charge portion that is connected with the conduit that is used for pumping blood and above-mentioned person in charge portion is connected with the inside of said vesse main body and above-mentioned person in charge portion is fixed on fixed part on the outer surface of said vesse main body,
The axis of above-mentioned person in charge portion is with respect to the tangential tilt of the outer surface of said vesse main body.
2. blood treatment filter according to claim 1 is characterized in that,
Above-mentioned beveled end oral area is for forming the entrance side port part of above-mentioned inlet.
3. blood treatment filter according to claim 1 is characterized in that,
Above-mentioned beveled end oral area is for forming the outlet side port part of above-mentioned outlet.
4. blood treatment filter according to claim 1 is characterized in that,
Above-mentioned beveled end oral area is entrance side port part that forms above-mentioned inlet and the outlet side port part that forms above-mentioned outlet.
5. blood filtration method that adopts the blood treatment filter, this blood treatment filter comprises the flexible container of inlet with blood and outlet and is configured to this internal tank is separated into the flaky blood treatment filtration members of entrance side and outlet side, it is characterized in that
Above-mentioned flexible container has the container body that is used to hold above-mentioned blood treatment filtration members and is fixed on the said vesse main body and forms the beveled end oral area of above-mentioned inlet or above-mentioned outlet, above-mentioned beveled end oral area has the person in charge portion that is connected with the conduit that is used for pumping blood and above-mentioned person in charge portion is connected with the inside of said vesse main body and above-mentioned person in charge portion is fixed on fixed part on the outer surface of said vesse main body
Above-mentioned person in charge portion is tilted with respect to the outer surface of said vesse main body, and, above-mentioned person in charge portion applied pulling force and guarantee between above-mentioned blood treatment filtration members and said vesse main body to the direction of leaving from the blood treatment filtration members spatially filter simultaneously.
Applications Claiming Priority (2)
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|---|---|---|---|
| US31891310P | 2010-03-30 | 2010-03-30 | |
| US61/318,913 | 2010-03-30 |
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| CN2011200941134U Expired - Lifetime CN202036596U (en) | 2010-03-30 | 2011-03-29 | Blood processing filter |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623475A (en) * | 2012-08-22 | 2014-03-12 | 上海输血技术有限公司 | Leukocyte-depleted cell filter with multiple filtering units |
| CN107708760A (en) * | 2015-06-17 | 2018-02-16 | 旭化成医疗株式会社 | Blood processing filter filter element, blood processing filter and blood processing |
| CN108635629A (en) * | 2014-03-10 | 2018-10-12 | 旭化成医疗株式会社 | blood processing filter |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5806815B2 (en) * | 2010-03-30 | 2015-11-10 | 旭化成メディカル株式会社 | Blood treatment filter and blood filtration method |
| CN102258814A (en) * | 2011-04-27 | 2011-11-30 | 佛山市博新生物科技有限公司 | Blood purifier end cover with spiral entrance |
| US9968738B2 (en) * | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
| CN106456850A (en) * | 2014-07-07 | 2017-02-22 | 旭化成医疗株式会社 | Blood treatment filter and blood treatment filter manufacturing method |
| CN106456852B (en) * | 2014-07-07 | 2019-02-26 | 旭化成医疗株式会社 | The manufacturing method of blood processing filter and blood processing filter |
| RU167888U1 (en) * | 2015-10-13 | 2017-01-11 | федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский национальный исследовательский технологический университет" (ФГБОУ ВО "КНИТУ") | Dialyzer |
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| US4985153A (en) * | 1988-06-23 | 1991-01-15 | Asahi Medical Co., Ltd. | Method for separating blood into blood components, and blood components separator unit |
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| CN2595372Y (en) * | 2003-01-04 | 2003-12-31 | 淄博中保康医疗器具有限公司 | Disposable filter for removing white blood cell |
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| CN103623475A (en) * | 2012-08-22 | 2014-03-12 | 上海输血技术有限公司 | Leukocyte-depleted cell filter with multiple filtering units |
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| CN108635629A (en) * | 2014-03-10 | 2018-10-12 | 旭化成医疗株式会社 | blood processing filter |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2011072816A (en) | 2011-04-14 |
| CN202036596U (en) | 2011-11-16 |
| JP5806815B2 (en) | 2015-11-10 |
| CN102205154B (en) | 2014-05-07 |
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