CN102266240A - Acoustic-electric joint analysis device used for tumor detection - Google Patents
Acoustic-electric joint analysis device used for tumor detection Download PDFInfo
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- CN102266240A CN102266240A CN2011102408717A CN201110240871A CN102266240A CN 102266240 A CN102266240 A CN 102266240A CN 2011102408717 A CN2011102408717 A CN 2011102408717A CN 201110240871 A CN201110240871 A CN 201110240871A CN 102266240 A CN102266240 A CN 102266240A
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Abstract
The invention provides an acoustic-electric joint analysis device used for detection. The device comprises a signal source excitation module, a detection signal receiving and transmitting module, a data acquisition module, an imaging module and an image joint analysis module which are connected in turn. The analysis device can simultaneously transmit a high-frequency ultrasonic signal and an ultra wide band (UWB) electromagnetic wave signal to detect human tissues, perform signal processing and imaging algorithm processing after receiving backward waves to respectively obtain grey-scale maps about the ultrasonic signal and the electromagnetic wave signal, and finally perform comprehensive processing and analysis on the two grey-scale maps. More detection details can be acquired and more accurate pathological analysis can be made by complementing the high specificity of ultrasonic imaging and the high sensitivity of the UWB electromagnetic wave imaging.
Description
Technical field
The invention belongs to medical science Detection Techniques field, be specifically related to ultra sonic imaging, ultra broadband imaging, complementary series coded pulse detection and image association analytical equipment.
Background technology
Cancer is the frequently-occurring disease and the commonly encountered diseases of a class serious threat human health.Over nearly 30 years, cancer morbidity and mortality rate are in rising trend always.Related data shows that tumor has become one of major causes of death of China resident, and the form of resisting cancer is quite severe.
Though the tumor Medical Technology of bringing in constant renewal in has been gathered various means such as operation, radiotherapy, chemotherapy, biological gene, be middle and advanced stage when finding cancer owing to the most tumors patient, good again Therapeutic Method also can only be felt frustrated.So, how correctly to diagnose out tumor in early days in cancer, for plenty of time is won in treatment, just become the key point that can cure tumor.
At present, medically had several different methods tumor has been detected and imaging, as X ray photography, computed tomography, NMR (Nuclear Magnetic Resonance)-imaging, ultrasound detection and ultra broadband near field imaging technique etc.X ray photography is lower for the sensitivity of the infantile tumour of no calcification, thereby detection error rate and loss are all higher, and accepts the X-ray irradiation repeatedly and can cause ionizing radiation to gather in vivo, might cause the normal structure canceration.The photography of computed tomography and X ray exists same problem: the radiation of tomoscan can penetration cell, destroy DNA, even brings out some cancerous cell.Though nuclear magnetic resonance technique does not have harmful effect to human body, its spatial resolution is not as good as computed tomography, and the equipment cost costliness, is not suitable for large-scale mass survey.Yet the performance of two kinds of technology of ultra sonic imaging and ultra broadband (UWB) imaging is comparatively desirable.
Ultrasonic imaging technique is whether the decay according to ultrasonic echo detects and have abnormal structure to exist.Ultrasonic in medium with straightline propagation, good directivity is arranged, this is the basis of tissue or organ being detected with ultrasonic.When ultrasound wave arrives the interface of the different adjacent media of two kinds of acoustic impedances, will reflect, and acoustic impedance difference is big more, volume reflection is also big more.Acoustic impedance is defined as: Z=P*C, and P is a Media density in the formula, C is the velocity of sound in the tissue.Generally speaking, the spread speed of the velocity of sound in tissue changes little, changes about 1500m/s.Studies show that the density of tumor tissues will be far longer than normal structure, so the two acoustic impedance exists than big-difference, promptly tumor tissues has stronger acoustic reflection and scattering effect than near normal structure.The pick off at receiving transducer place is collected echo, and is formed the image contrast scattergram of different material, tissue or organ by algorithm process.On ultrasonoscopy, strong echo is reflected as Bai Ying (clear zone), weak echo or do not have echo and be reflected as shadow (dark space).Ultrasonic detecting technology have high specific, non-invasive, equipment cost is low and resolution than advantages such as height, be applicable to that lump is less, the clinical focus that down is difficult for touching.
The UWB imaging technique is whether the decay according to signal echo detects and have abnormal structure to exist equally.UWB electromagnetic wave propagation characteristic is relevant with the dielectric property of tissue, the difference in dielectric constant of two media is big more, its electromagnetic volume reflection in interface place is just big more, and dielectric property is with organizing liquid content that substantial connection is arranged, studies show that, the liquid content of general tumor tissues will far above around normal structure, so the dielectric property of tumor tissues and normal structure differs greatly, so electromagnetic wave signal produces bigger reflection and scattered quantum at its interface place.Receptor is collected echo, and handle, imaging.The UWB detection signal is generally the burst pulse of ns level, and penetration power is strong, and the positioning accuracy height has hypersensitivity in being detected as picture, be easy to find infantile tumour; In addition, the UWB signal energy is little, and the X-ray imaging is much smaller to the harm of human body relatively.Therefore this technology has sizable clinical meaning.
Summary of the invention
Based on the important meaning of tumor Detection Techniques, at the know-why and the advantage of the deficiencies in the prior art and combined echocardiography imaging and UWB imaging, the present invention proposes a kind of acoustoelectric combined analytical equipment that tumor is surveyed that is used for.Consider that acoustical signal detects and the electromagnetic wave signal detection has utilized the acoustic characteristic and the electrology characteristic of material respectively, and these two kinds of signals can not interfere with each other, so their transmitting terminal can be integrated in the less module, and can detect target simultaneously.The present invention launches high-frequency ultrasonic signal simultaneously and the UWB electromagnetic wave signal detects tissue, handle the gray-scale map that obtains respectively about ultrasonic signal and electromagnetic wave signal through signal processing and imaging algorithm after receiving echo, at last two width of cloth gray-scale maps are carried out integrated treatment and analysis, utilize the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, to obtain more detection details and to make pathological analysis more accurately.
For achieving the above object, the present invention adopts following technical scheme:
A kind of acoustoelectric combined analytical equipment that is used for the tumor detection comprises the signal source stimulating module, detectable signal transceiver module, data acquisition module, imaging processing module and the image association analysis module that connect in turn; Described signal source stimulating module is used for producing simultaneously one road high frequency complementary series coded pulse excitation and one road UWB complementary series coded pulse excitation; Described detectable signal transceiver module is launched high-frequency ultrasonic signal and UWB electromagnetic wave signal simultaneously to surveyed area after being subjected to the excitation of signal source forcing module; Described detectable signal transceiver module receives the echo of two kinds of signals, and the two-way echo-signal is carried out the complementary series decoding and delivered to data acquisition module; The decoded echo-signal of described data collecting module collected two-way also produces the required data of imaging after treatment, two paths of data is delivered to the imaging processing module again; The two paths of data of described imaging processing module to receiving generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, again two width of cloth gray-scale maps delivered to the image association analysis module; Described image association analysis module carries out difference to two width of cloth figure and extracts and feature extraction, forms the feature pattern, and makes analysis-by-synthesis.
In the above-mentioned analytical equipment, described signal source stimulating module comprises two parts: a part forms device by high-frequency impulse and the first complementary series encoder constitutes, and produces high frequency complementary series coded pulse excitation, is used to encourage the ultrasonic probe of detectable signal transceiver module; Another part is made of the UWB pulse shaper and the second complementary series encoder, the UWB pulse shaper produces Gauss's burst pulse, encoded device production burst sequence, this UWB complementary series coded pulse excitation is used to encourage the electromagnetic antenna of detectable signal transceiver module.
In the above-mentioned analytical equipment, described complementary series encoder adopts the complementary series sign indicating number as coded pulse sequence, and the activation sequence of described encoder output is made up of two 16 complementary series A, B, and activation sequence C is by A, the B composition that is connected, the complementary series sign indicating number has autocorrelation performance.
In the above-mentioned analytical equipment, described detectable signal transceiver module comprises ultrasonic probe, electromagnetic antenna and the decoder of receiving and dispatching consubstantiality, ultrasonic probe and electromagnetic antenna are respectively after coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal respectively, and receive echo-signal separately; Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
In the above-mentioned analytical equipment, described data acquisition equipment is handled respectively the decoded echo-signal of two-way: the detection of echoes signal intensity generates normalized intensity level s; Form then data format for ((x, y), two paths of data s), and deliver to the imaging processing module, wherein x and y are respectively the abscissa and the vertical coordinates of scanning impact point.
In the above-mentioned analytical equipment, described imaging processing module utilizes imaging algorithm that the two-way echo strength Value Data that receives is carried out imaging processing respectively, generation is about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
In the above-mentioned analytical equipment, described image association analysis module receives two width of cloth gray-scale maps that the imaging processing module transmits, and utilizes the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, and makes pathological analysis.
In the above-mentioned analytical equipment, the image association analysis module finish following work:
The first, in the UWB signal graph, extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency, form " acoustoelectric signal disparity map ", and be presented on the display separately;
The second, ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", the comparison by the feature pattern provides reference information Xiang the doctor; The image association analysis module at first to two width of cloth gray-scale maps extraction eigenvalue separately, forms the feature pattern in identical feature space; Calculate the center of gravity O of two feature patterns then respectively
1And O
2, and calculate O
1And O
2Distance D in feature space=| O
1-O
2|; At last carry out following analysis according to the value of D:
(1) if satisfy D＞Th, two feature pattern similarity height then illustrate the detection effect basically identical of two paths of signals;
(2) if satisfy Tl＜D＜Th, then two feature patterns are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, and prompting must be analyzed just with reference to ultrasonic signal figure and can draw conclusion more accurately thus;
(3) if satisfy D＜Tl, then two feature pattern similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw are provided may be unreliable, needs to consider to detect again, and wherein Tl and Th are the threshold values of presetting.
The analytical method of above-mentioned analytical equipment may further comprise the steps:
Step 1, in the signal source stimulating module, the output of high frequency pulse generator produces high-frequency coding pulse excitation sequence through the complementary series encoder; The output of UWB pulse shaper produces UWB coded pulse activation sequence through the complementary series encoder.Excitation signals is sent to the detectable signal transceiver module simultaneously.
After ultrasonic probe in step 2, the detectable signal transceiver module and electromagnetic antenna are encouraged, launch high frequency ultrasound pulse sequence signal and UWB electromagnetic impulse sequence signal respectively, simultaneously surveyed area is scanned.
Ultrasonic probe in step 3, the detectable signal transceiver module and electromagnetic antenna receive the echo of high-frequency ultrasonic signal and the echo of UWB electromagnetic wave signal respectively, and two-way echo-signal input decoder is decoded.
Step 4, decoded two paths of signals enter data acquisition module, and this module is handled decoded echo-signal, produce required " coordinate-intensity " data of imaging, and data are delivered to the imaging processing module through two-way.
Step 5, imaging processing module utilize imaging algorithm that the two paths of data that receives is carried out imaging processing respectively, generate about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
Step 6, described image association analysis module carry out conjoint analysis to figure of high-frequency ultrasonic signal and the UWB electromagnetic wave signal figure that the imaging processing module transmits: at first extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency in the UWB signal graph, form " acoustoelectric signal disparity map ", allow the doctor that the tumor character is made preliminary assurance intuitively, fast; Then ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", form the feature pattern, and calculate the distance of geometric center of gravity in feature space of these two feature patterns, reliable with judging whether of this time making of this value checking.
The technical scheme of the present invention is integrated supersonic sounding and UWB electromagnetic wave detection has following advantage and technique effect:
1, utilize the acoustic characteristic of material and electrology characteristic to survey simultaneously, two kinds of different detectable signals of physical property are carried out integrated treatment and analysis, thereby obtain more target detail, making has more reference information when analyzing pathology character.
2, utilize the high specific of ultra sonic imaging to reduce the erroneous judgement situation that causes because of UWB imaging hypersensitivity, thereby improve the accuracy of pathological analysis; Utilize the hypersensitivity and the pinpoint accuracy of UWB imaging to obtain the edge details abundanter, thereby obtain more pathological informations as analyzing foundation than ultra sonic imaging.
3, ultrasonic signal and electromagnetic wave signal do not disturb mutually, its transmitting terminal can be integrated in the less module, and can transmit and receive this two kinds of detection signals simultaneously, and therefore comparing with the single checkout gear of planting signal of emission, the present invention can't expend the more time cost.
4, adopt the complementary series coded pulse to survey, can obtain higher signal to noise ratio.
Description of drawings
Fig. 1 is a theory diagram of the present invention;
Fig. 2 a is the ultra sonic imaging sketch map of tumor;
Fig. 2 b is the UWB imaging sketch map of tumor;
Fig. 2 c is the acoustoelectric signal disparity map of tumor;
Fig. 3 is a workflow diagram of the present invention;
Fig. 4 is the workflow diagram of image association analysis module;
Fig. 5 a is the figure of a high-frequency ultrasonic signal feature pattern sketch map;
Fig. 5 b is a UWB electromagnetic wave signal figure feature pattern sketch map.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment and accompanying drawing, but embodiments of the present invention are not limited thereto.
Embodiment
As shown in Figure 1, the present invention is made up of 5 modules: signal source stimulating module, detectable signal transceiver module, data acquisition module, imaging processing module and image association analysis module.Wherein, dotted arrow is represented detectable signal in the direction of propagation that produces, sends the stage, and solid arrow represents that echo-signal is in reception, processing, the direction of propagation in imaging stage.The signal source stimulating module produces one road high frequency complementary series coded pulse excitation and one road UWB complementary series coded pulse excitation simultaneously, after the detectable signal transceiver module excited target, simultaneously to surveyed area emission high-frequency ultrasonic signal and UWB electromagnetic wave signal; The detectable signal transceiver module receives the echo of two kinds of signals, the two-way echo-signal is decoded and delivers to data acquisition module; Data acquisition module, this module is handled respectively the decoded echo-signal of two-way, produces the required data of imaging, two paths of data is delivered to the imaging processing module again; The imaging processing module utilizes imaging algorithm that the two paths of data that receives is handled respectively, generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module; The image association analysis module carries out difference to two width of cloth figure and extracts and feature extraction, forms the feature pattern, and makes analysis-by-synthesis.
Described signal source stimulating module comprises two-way excitation output.One route high-frequency impulse forms device and constitutes based on the first complementary series encoder of DSP TMS320C50, produces sequence of high frequency pulses, is used to encourage the ultrasonic probe of detectable signal transceiver module; Another route UWB pulse shaper and constitute based on the second complementary series encoder of DSPTMS320C50, the UWB pulse shaper produces Gauss's burst pulse, encoded device production burst sequence, this UWB pulse train is used to encourage the electromagnetic antenna of detectable signal transceiver module.
Adopt the coded pulse energisation mode to survey herein and can obtain higher signal to noise ratio, its principle is as follows:
Suppose that the quantity of information that enters decoder is: C
i=B
iLog
2(1+S
i/ N
i), decoder is B with bandwidth
iInput signal to be demodulated into bandwidth be B
oOutput signal, its quantity of information is: C
o=B
oLog
2(1+S
o/ N
o).C is a quantity of information in the formula; B is a signal bandwidth; S is a signal power; The N noise power; Subscript i, o represent the decoder input and output respectively.Because the input signal of decoder and output signal must have equal quantity of information, promptly have: B
iLog
2(1+S
i/ N
i)=B
oLog
2(1+S
o/ N
o).Generally speaking, S/N＞＞1, then (B
i/ B
o) log
2(S
i/ N
i) ≈ log
2(S
o/ N
o), and because chnnel coding has increased redundancy to information source, therefore the signal of signal behind ratio decoder in the unit interval before the decoding has bigger data volume, and B is promptly arranged
i＞B
oSo, S
o/ N
o＞S
i/ N
i, so coding system can be obtained higher signal to noise ratio.
The present invention adopts the complementary series sign indicating number as coded pulse sequence.The activation sequence of described encoder output is made up of two 16 complementary series A, B, and activation sequence C is by A, the B composition that is connected.The complementary series sign indicating number has ideal autocorrelation performance, and good autocorrelation performance can guarantee can obtain imaging clearly after echo-signal is through decoding.
Described detectable signal transceiver module is formed by the ultrasonic probe, electromagnetic antenna of transmitting-receiving consubstantiality with based on the decoder of DSPTMS320C50.Ultrasonic probe and electromagnetic antenna are respectively after coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal respectively, and receive echo-signal separately.Because acoustical signal is different with signal of telecommunication physical property, do not disturb mutually, therefore can in same module, transmit and receive simultaneously.Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
Described data acquisition module adopts the EM200 module of Huawei Company, and the decoded echo-signal of two-way is handled respectively: the detection of echoes signal intensity generates normalized intensity level s; Form then data format for ((x, y), two paths of data s), and deliver to the imaging processing module, wherein x and y are respectively the abscissa and the vertical coordinates of scanning impact point.
Described imaging processing module adopts the TMS34020 chip of TI company, utilize imaging algorithm that the two-way echo strength Value Data that receives is carried out imaging processing respectively, generation is about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
Described image association analysis module is realized that by computer software two width of cloth gray-scale maps that the imaging processing module is transmitted carry out analysis-by-synthesis, to draw than single signal detection pathological analysis result more accurately.The meaning of conjoint analysis is to utilize the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, to obtain more detection details and to make pathological analysis more accurately:
At first, ultrasonic signal figure can remedy the deficiency of UWB signal graph on the accuracy of judgement degree: the UWB imaging has hypersensitivity, occurs the erroneous judgement situation easily, might draw positive findings to cyst or most of calcification kitchen range.For example, the UWB imaging of cyst might be the real property bulk of white, and is closely similar with tumor imaging, is easy to generate erroneous judgement.And hot spot or light belt can appear in the ultrasonic image of cyst, be easy to distinguish with tumor imaging.Therefore, the high specific of ultra sonic imaging can be made accurate judgement to cyst or calcification kitchen range, thereby be reduced the probability of miscarriage of justice of UWB electromagnetic wave signal figure to a certain extent.
In addition, the UWB signal graph also can remedy the deficiency of ultrasonic signal figure in detail: generally speaking, around the carcinoid lump the complete fibroid peplos of one deck is arranged, its image boundary is more clearly; And the periphery of malignant tumor lump does not have peplos, or peplos is incomplete, presents ambiguous border on the traditional medicine image, and generally there is different local edges in the malignant tumor image of different pathological character.Therefore, accurately catch the pathology character that borderline tumor helps to analyze tumor.The high accuracy that UWB detects can obtain more edge details than ultrasound detection, and can also detect the diffusion trend of cancerous cell, as shown in Figure 2: Fig. 2 a is the ultra sonic imaging sketch map of tumor, and white portion is detected tumor region, its edge is dim shadow region, and is smudgy; The ash color part is other normal structures; Fig. 2 b is the UWB imaging sketch map of tumor, and white portion is detected tumor region equally, and different is that the shadow region at its edge is more clear than the edge among the ultrasonic figure, bright, easier observation.And can find out that cancerous cell just spreads toward the upper right side.In addition, the hypersensitivity of UWB imaging makes it than the easier early-stage cancer that detects of ultra sonic imaging.
This shows that ultrasonic signal figure and UWB electromagnetic wave signal figure can be complementary not enough, comprehensive two figure analyze just can make accurately and judge.
The doctor analyzes and makes more accurately and judge that described image association analysis module carries out further Combined Treatment to ultrasonic signal figure and the UWB signal graph that the imaging processing module transmits for convenience.The image association analysis module mainly contains two work:
First, in the UWB signal graph, extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency, form " acoustoelectric signal disparity map ", and be presented on the display separately, shown in Fig. 2 c: what this figure reflected mainly is the edge configuration of tumor and the spread condition of cancerous cell, can allow the doctor that the tumor character is made preliminary analysis and judgement intuitively, fast.
The second, ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", the comparison by the feature pattern provides more reference information Xiang the doctor.The image association analysis module at first to two width of cloth gray-scale maps extraction eigenvalue CH1, CH2......CHh separately, forms the feature pattern in identical feature space; Calculate the center of gravity O of two feature patterns then respectively
1And O
2, and calculate O
1And O
2Distance D in feature space=| O
1-O
2|; At last according to judging whether reliably that the value checking of D is made before this.Specifically carry out following analysis:
(1) if satisfy D＞Th, two feature pattern similarity height then illustrate the detection effect basically identical of two paths of signals, and the analysis of carrying out will have higher accuracy on this basis.
(2) if satisfy Tl＜D＜Th, then two feature patterns are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, points out the doctor to analyze just with reference to ultrasonic signal figure thus and can draw conclusion more accurately.
(3) if satisfy D＜Tl, then two feature pattern similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw are provided may be unreliable, and the doctor need consider to detect again.(wherein Tl and Th are the threshold values of presetting.)
In sum, described image association analysis module at first forms " acoustoelectric signal disparity map ", allows the doctor that the tumor character is made preliminary assurance intuitively, fast; Feature pattern on its feature space compares to ultrasonic signal figure and UWB signal graph then, and judging whether that checking is this time made is reliable.
Adopt the coded pulse energisation mode to survey and to obtain higher signal to noise ratio.For realizing this function, present embodiment adopts the complementary series sign indicating number as coded pulse sequence.The activation sequence of described encoder output is made up of two 16 complementary series A, B, A={1 wherein, 1,1 ,-1 ,-1 ,-1,1 ,-1 ,-1 ,-1,-1,1 ,-1 ,-1,1 ,-1}, B={1,1,1 ,-1 ,-1,-1,1 ,-1,1,1,1 ,-1,1,1 ,-1,1}, then activation sequence is C={A, B}={1,1,1 ,-1 ,-1 ,-1,1 ,-1 ,-1 ,-1,-1,1 ,-1 ,-1,1 ,-1,1,1,1 ,-1 ,-1,-1,1 ,-1,1,1,1 ,-1,1,1 ,-1,1}.The complementary series sign indicating number has ideal autocorrelation performance, and good autocorrelation performance can guarantee can obtain imaging clearly after echo-signal is through decoding.
Described detectable signal transceiver module is made up of ultrasonic probe, electromagnetic antenna and the decoder of transmitting-receiving consubstantiality.Ultrasonic probe and electromagnetic antenna are respectively after coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal respectively, and receive echo-signal separately.Because acoustical signal is different with signal of telecommunication physical property, do not disturb mutually, therefore can in same module, transmit and receive simultaneously.Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
Described data acquisition equipment is handled respectively the decoded echo-signal of two-way: the detection of echoes signal intensity generates normalized intensity level s; Be data format that ((x, y), two paths of data s) is delivered to the imaging processing module then.
Described imaging processing module utilizes imaging algorithm that the two paths of data that receives is carried out imaging processing respectively, generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
As shown in Figure 3, present embodiment adopts following job step:
Step 1, in the signal source stimulating module, the output of high frequency pulse generator produces high-frequency coding pulse excitation sequence through complementary series encoder 1; The output of UWB pulse shaper produces UWB coded pulse activation sequence through complementary series encoder 2.Excitation signals is sent to the detectable signal transceiver module simultaneously.
After ultrasonic probe in step 2, the detectable signal transceiver module and electromagnetic antenna are encouraged, launch high frequency ultrasound pulse sequence signal and UWB electromagnetic impulse sequence signal respectively, simultaneously surveyed area is scanned.
Ultrasonic probe in step 3, the detectable signal transceiver module and electromagnetic antenna receive the echo of high-frequency ultrasonic signal and the echo of UWB electromagnetic wave signal respectively, and two-way echo-signal input decoder is decoded.
Step 4, decoded two paths of signals enter data acquisition module, and this module is handled decoded echo-signal, produce required " coordinate-intensity " data of imaging, and data are delivered to the imaging processing module through two-way.
Step 5, imaging processing module utilize imaging algorithm that the two paths of data that receives is carried out imaging processing respectively, generate about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
Step 6, described image association analysis module carry out conjoint analysis to figure of high-frequency ultrasonic signal and the UWB electromagnetic wave signal figure that the imaging processing module transmits: at first extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency in the UWB signal graph, form " acoustoelectric signal disparity map ", allow the doctor that the tumor character is made preliminary assurance intuitively, fast; Then ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", form the feature pattern, and calculate the distance of geometric center of gravity in feature space of these two feature patterns, reliable with judging whether of this time making of this value checking.
As shown in Figure 4, described image association analysis module adopts following job step:
Step 1, in the UWB signal graph, extract the zone that is lower than preset gate limit value TH with ultrasonic signal figure dependency, form " acoustoelectric signal disparity map ", tentatively hold the tumor character.
Step 2, respectively high-frequency ultrasonic signal figure and UWB electromagnetic wave signal figure are carried out feature extraction, calculate its eigenvalue separately: CH1, CH2......CHh.
Step 3, basis eigenvalue generating feature pattern on identical feature space separately (suppose to have 6 features) shown in Fig. 5 a and Fig. 5 b.
The geometric center of gravity O of step 4, two feature patterns of calculating
1And O
2, and calculate O
1And O
2Distance D in feature space.
Step 5, further analyze according to the value of D:
(1) if satisfy D＞Th, two feature pattern similarity height then illustrate the detection effect basically identical of two paths of signals, and the analysis of carrying out will have higher accuracy on this basis.
(2) if satisfy Tl＜D＜Th, then two feature patterns are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, points out the doctor to analyze just with reference to ultrasonic signal figure thus and can draw conclusion more accurately.
(3) if satisfy D＜Tl, then two feature pattern similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw are provided may be unreliable, and the doctor need consider to detect again.(wherein Tl and Th are the threshold values of presetting.)
The technical scheme of the present invention is integrated ultrasonic imaging and the imaging of UWB electromagnetic wave is carried out feature extraction to the echo of two kinds of detectable signals, forms the feature pattern, and carries out conjoint analysis.Characteristics of the present invention are: utilize two kinds of different signals of physical property to survey, can obtain more target detail, for pathological analysis provides more reference information; Utilize the high specific of ultra sonic imaging and hypersensitivity, the pinpoint accuracy of UWB imaging to carry out complementation, thereby make the pathological analysis result more accurate; Supersonic sounding and electromagnetic wave detection do not disturb mutually, can carry out simultaneously, thus the time cost of saving detecting operation, and the transmitting terminal of two kinds of signals can be integrated in the less module; Adopt coded pulse to survey, can obtain higher signal to noise ratio.The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (8)
1. one kind is used for the acoustoelectric combined analytical equipment that tumor is surveyed, and it is characterized in that comprising the signal source stimulating module, detectable signal transceiver module, data acquisition module, imaging processing module and the image association analysis module that connect in turn;
Described signal source stimulating module is used for producing simultaneously one road high frequency complementary series coded pulse excitation and one road UWB complementary series coded pulse excitation; Described detectable signal transceiver module is launched high-frequency ultrasonic signal and UWB electromagnetic wave signal simultaneously to surveyed area after being subjected to the excitation of signal source forcing module; Described detectable signal transceiver module receives the echo of two kinds of signals, and the two-way echo-signal is carried out the complementary series decoding and delivered to data acquisition module; The decoded echo-signal of described data collecting module collected two-way also produces the required data of imaging after treatment, two paths of data is delivered to the imaging processing module again; The two paths of data of described imaging processing module to receiving generates about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, again two width of cloth gray-scale maps delivered to the image association analysis module; Described image association analysis module carries out difference to two width of cloth figure and extracts and feature extraction, forms the feature pattern, and makes analysis-by-synthesis.
2. analytical equipment according to claim 1, it is characterized in that described signal source stimulating module comprises two parts: a part forms device by high-frequency impulse and the first complementary series encoder constitutes, produce high frequency complementary series coded pulse excitation, be used to encourage the ultrasonic probe of detectable signal transceiver module; Another part is made of the UWB pulse shaper and the second complementary series encoder, the UWB pulse shaper produces Gauss's burst pulse, encoded device production burst sequence, this UWB complementary series coded pulse excitation is used to encourage the electromagnetic antenna of detectable signal transceiver module.
3. analytical equipment according to claim 2 is characterized in that described complementary series encoder adopts the complementary series sign indicating number as coded pulse sequence, and the activation sequence of described encoder output is by two 16 complementary series
A,
BForm activation sequence
CBy
A, BThe composition that is connected, the complementary series sign indicating number has autocorrelation performance.
4. analytical equipment according to claim 1, it is characterized in that described detectable signal transceiver module comprises ultrasonic probe, electromagnetic antenna and the decoder of receiving and dispatching consubstantiality, ultrasonic probe and electromagnetic antenna are respectively after coded pulse of high frequency complementary series and UWB complementary series coded pulse excitation, scan to surveyed area simultaneously, launch high frequency ultrasound detection signal and UWB Electromagnetic Wave Detection signal respectively, and receive echo-signal separately; Decoder carries out being sent to data acquisition module after the complementary series decoding to the two-way echo-signal.
5. analytical equipment according to claim 1, it is characterized in that described data acquisition equipment handles respectively the decoded echo-signal of two-way: the detection of echoes signal intensity generates normalized intensity level
sForm then data format for ((
X, y)
, s) two paths of data, and deliver to the imaging processing module, wherein
xWith
yBe respectively the abscissa and the vertical coordinate of scanning impact point.
6. analytical equipment according to claim 5, it is characterized in that described imaging processing module utilizes imaging algorithm that the two-way echo strength Value Data that receives is carried out imaging processing respectively, generation is about the gray-scale map of ultrasonic signal with about the gray-scale map of electromagnetic wave signal, and two width of cloth gray-scale maps are delivered to the image association analysis module.
7. analytical equipment according to claim 6, it is characterized in that described image association analysis module receives two width of cloth gray-scale maps that the imaging processing module transmits, utilize the high specific of ultra sonic imaging and the hypersensitivity of UWB electromagnetic wave imaging to carry out complementation, and make pathological analysis.
8. analytical equipment according to claim 7 is characterized in that the following work of finishing of image association analysis module:
The first, in the UWB signal graph, extract with ultrasonic signal figure dependency and be lower than the preset gate limit value
THThe zone, form " acoustoelectric signal disparity map ", and be presented on the display separately;
The second, ultrasonic signal figure and UWB signal graph are transformed on " feature space " from " coordinate-gray value space ", the comparison by the feature pattern provides reference information Xiang the doctor; The image association analysis module at first to two width of cloth gray-scale maps extraction eigenvalue separately, forms the feature pattern in identical feature space; Calculate the center of gravity of two feature patterns then respectively
With
, and calculate
With
Distance in feature space
Last basis
DValue carry out following analysis:
(1) if satisfies
, two feature pattern similarity height then illustrate the detection effect basically identical of two paths of signals;
(2) if satisfy
, then two feature patterns are similar not high, and instruction book is analyzed from UWB electromagnetic wave image may cause erroneous judgement, and prompting must be analyzed just with reference to ultrasonic signal figure and can draw conclusion more accurately thus;
(3) if satisfy
, then two feature pattern similarities are very low, illustrate wherein one the tunnel to detect and may make mistakes, and the information that these two width of cloth gray-scale maps that draw are provided may be unreliable, needs to consider to detect again, wherein
With
It is the threshold value of presetting.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4641659A (en) * | 1979-06-01 | 1987-02-10 | Sepponen Raimo E | Medical diagnostic microwave scanning apparatus |
| US20100036240A1 (en) * | 2008-08-07 | 2010-02-11 | Ismail Aly M | Multi-modality system for imaging in dense compressive media and method of use thereof |
| US20100069744A1 (en) * | 2006-03-10 | 2010-03-18 | Ray Andrew Simpkin | Imaging System |
| CN202211713U (en) * | 2011-08-22 | 2012-05-09 | 华南理工大学 | Acoustoelectric conjoint analysis device for detecting tumors |
-
2011
- 2011-08-22 CN CN2011102408717A patent/CN102266240B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4641659A (en) * | 1979-06-01 | 1987-02-10 | Sepponen Raimo E | Medical diagnostic microwave scanning apparatus |
| US20100069744A1 (en) * | 2006-03-10 | 2010-03-18 | Ray Andrew Simpkin | Imaging System |
| US20100036240A1 (en) * | 2008-08-07 | 2010-02-11 | Ismail Aly M | Multi-modality system for imaging in dense compressive media and method of use thereof |
| CN202211713U (en) * | 2011-08-22 | 2012-05-09 | 华南理工大学 | Acoustoelectric conjoint analysis device for detecting tumors |
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