CN102498204B - 人脐带组织细胞作为用于阿尔茨海默病的疗法 - Google Patents
人脐带组织细胞作为用于阿尔茨海默病的疗法 Download PDFInfo
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- CN102498204B CN102498204B CN201080023803.9A CN201080023803A CN102498204B CN 102498204 B CN102498204 B CN 102498204B CN 201080023803 A CN201080023803 A CN 201080023803A CN 102498204 B CN102498204 B CN 102498204B
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N2510/00—Genetically modified cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
Abstract
Description
酶消化 | 分离的细胞 | 细胞扩增 |
胶原酶 | X | X |
分散酶 | +(>10h) | + |
透明质酸酶 | X | X |
胶原酶:分散酶 | ++(<3h) | ++ |
胶原酶:透明质酸酶 | ++(<3h) | + |
分散酶:透明质酸酶 | +(>10h) | + |
胶原酶:分散酶:透明质酸酶 | +++(<3h) | +++ |
细胞类型 | 衰老 | 总群体倍增 | 得率(总细胞) |
MSC | 24d | 8 | 4.72 E7 |
脂肪-来源的细胞 | 57d | 24 | 4.5 E12 |
成纤维细胞 | 53d | 26 | 2.82 E13 |
脐 | 65d | 42 | 6.15 E17 |
胎盘 | 80d | 46 | 2.4 E19 |
细胞类型(传代编号) | 衰老 | 总群体倍增 | 得率(总细胞) |
成纤维细胞(P10) | 80天 | 43.68 | 2.59 E11 |
脐(P10) | 80天 | 53.6 | 1.25 E14 |
胎盘 | 60天 | 32.96 | 6.09 E12 |
组织 | 传代 | 计数的中期细胞 | 分析的中期细胞 | 核型数 | ISCN核型 |
胎盘 | 22 | 20 | 5 | 2 | 46,XX |
脐带 | 23 | 20 | 5 | 2 | 46,XX |
脐带 | 6 | 20 | 5 | 2 | 46,XY |
胎盘 | 2 | 20 | 5 | 2 | 46,XX |
脐带 | 3 | 20 | 5 | 2 | 46,XX |
胎盘-N | 0 | 20 | 5 | 2 | 46,XY |
胎盘-V | 0 | 20 | 5 | 2 | 46,XY |
胎盘-M | 0 | 21 | 5 | 4 | 46,XY[18]/46,XX[3] |
胎盘-M | 4 | 20 | 5 | 2 | 46,XX |
胎盘-N | 9 | 25 | 5 | 4 | 46,XY[5]/46,XX[20] |
胎盘-NC1 | 1 | 20 | 5 | 2 | 46,XY |
胎盘-NC3 | 1 | 20 | 6 | 4 | 46,XY[2]/46,XX[18] |
胎盘-NC4 | 1 | 20 | 5 | 2 | 46,XY |
胎盘-NC15 | 1 | 20 | 5 | 2 | 46,XY |
胎盘-NC20 | 1 | 20 | 5 | 2 | 46,XY |
胎盘-NC22 | 1 | 20 | 5 | 2 | 46,XY |
抗体 | 制造商 | 目录号 |
CD10 | BD Pharmingen(San Diego,CA) | 555375 |
CD13 | BD Pharmingen(San Diego,CA) | 555394 |
CD31 | BD Pharmingen(San Diego,CA) | 555446 |
CD34 | BD Pharmingen(San Diego,CA) | 555821 |
CD44 | BD Pharmingen(San Diego,CA) | 555478 |
CD45RA | BD Pharmingen(San Diego,CA) | 555489 |
CD73 | BD Pharmingen(San Diego,CA) | 550257 |
CD90 | BD Pharmingen(San Diego,CA) | 555596 |
CD117 | BD Biosciences(San Jose,CA) | 340529 |
CD141 | BD Pharmingen(San Diego,CA) | 559781 |
PDGFr-alpha | BD Pharmingen(San Diego,CA) | 556002 |
HLA-A,B,C | BD Pharmingen(San Diego,CA) | 555553 |
HLA-DR,DP,DQ | BD Pharmingen(San Diego,CA) | 555558 |
IgG-FITC | Sigma(St.Louis,MO) | F-6522 |
IgG-PE | Sigma(St.Louis,MO) | P-4685 |
MCP-1 | IL-6 | VEGF | SDF-1α | GCP-2 | IL-8 | TGF-β2 | |
成纤维细胞 | 17±1 | 61±3 | 29±2 | 19±1 | 21±1 | ND | ND |
脐(022803) | 1150±74 | 4234±289 | ND | ND | 160±11 | 2058±145 | ND |
脐(071003) | 2794±84 | 1356±43 | ND | ND | 2184±98 | 2639±23 | ND |
TIMP1 | ANG2 | PDGFbb | TPO | KGF | HGF | FGF | VEGF | HBEGF | BDNF | |
hFB | 19306.3 | ND | ND | 230.5 | 5.0 | ND | ND | 27.9 | 1.3 | ND |
U1 | 57718.4 | ND | ND | 1240.0 | 5.8 | 559.3 | 158.7 | ND | 9.3 | 165.7 |
U3 | 21850.0 | ND | ND | 1134.5 | 9.0 | 195.6 | 30.8 | ND | 5.4 | 388.6 |
MIP1a | MIP1b | MCP1 | RANTES | I309 | TARC | Eotaxin | MDC | IL8 | |
hFB | ND | ND | 39.6 | ND | ND | 0.1 | ND | ND | 204.9 |
U1 | ND | 8.0 | 1694.2 | ND | 22.4 | 37.6 | ND | 18.9 | 51930.1 |
U3 | ND | 5.2 | 2018.7 | 41.5 | 11.6 | 21.4 | ND | 4.8 | 10515.9 |
受者 | 胎盘 | |
板1(接受者1-3) | 279 | 3 |
板2(接受者4-6) | 46.25 | 1.3 |
受者 | 脐带 | |
板1(接受者1-4) | 42.75 | 6.5 |
板2(接受者5) | 70 | 9 |
Claims (2)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16361909P | 2009-03-26 | 2009-03-26 | |
US61/163619 | 2009-03-26 | ||
PCT/US2010/028930 WO2010111663A1 (en) | 2009-03-26 | 2010-03-26 | Human umbilical cord tissue cells as therapy for alzheimer' s disease |
Publications (2)
Publication Number | Publication Date |
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CN102498204A CN102498204A (zh) | 2012-06-13 |
CN102498204B true CN102498204B (zh) | 2015-02-04 |
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CN201080023803.9A Expired - Fee Related CN102498204B (zh) | 2009-03-26 | 2010-03-26 | 人脐带组织细胞作为用于阿尔茨海默病的疗法 |
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US (2) | US8722034B2 (zh) |
EP (1) | EP2411504B1 (zh) |
JP (1) | JP5908394B2 (zh) |
CN (1) | CN102498204B (zh) |
AU (1) | AU2010229651B2 (zh) |
BR (1) | BRPI1013409A2 (zh) |
CA (1) | CA2756600C (zh) |
ES (1) | ES2629003T3 (zh) |
PL (1) | PL2411504T3 (zh) |
SG (1) | SG174551A1 (zh) |
WO (1) | WO2010111663A1 (zh) |
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US20140234277A1 (en) | 2014-08-21 |
PL2411504T3 (pl) | 2017-10-31 |
US20100247499A1 (en) | 2010-09-30 |
BRPI1013409A2 (pt) | 2018-01-16 |
EP2411504B1 (en) | 2017-05-10 |
CA2756600C (en) | 2019-08-20 |
AU2010229651B2 (en) | 2014-05-08 |
SG174551A1 (en) | 2011-10-28 |
JP5908394B2 (ja) | 2016-04-26 |
EP2411504A1 (en) | 2012-02-01 |
JP2012522014A (ja) | 2012-09-20 |
CA2756600A1 (en) | 2010-09-30 |
US9943552B2 (en) | 2018-04-17 |
WO2010111663A1 (en) | 2010-09-30 |
ES2629003T3 (es) | 2017-08-07 |
AU2010229651A1 (en) | 2011-11-10 |
CN102498204A (zh) | 2012-06-13 |
US8722034B2 (en) | 2014-05-13 |
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