CN102614124A - Vaginal sterilizing foaming agent and preparation method thereof - Google Patents
Vaginal sterilizing foaming agent and preparation method thereof Download PDFInfo
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- CN102614124A CN102614124A CN2012101058547A CN201210105854A CN102614124A CN 102614124 A CN102614124 A CN 102614124A CN 2012101058547 A CN2012101058547 A CN 2012101058547A CN 201210105854 A CN201210105854 A CN 201210105854A CN 102614124 A CN102614124 A CN 102614124A
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- fatty acid
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- triethanolamine
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Abstract
The invention discloses a vaginal sterilizing foaming agent and a preparation method thereof. The vaginal sterilizing foaming agent comprises the following substances in part by mass: 0.1 to 0.3 part of bacteriacide, 32.0 to 38.0 parts of fatty acid, 2.8 to 5.0 parts of coconut oil fatty acid diethanolamide, 1.5 to 2.5 parts of lecithin, 9.5 to 10.5 parts of glycerol, 7.0 to 9.5 parts of triethanolamine, 0.1 part of menthol and 30 to 50 parts of deionized water. The preparation method comprises the following steps: A, melting fatty acid; B, preparing aqueous solution of triethanolamine; and C, mixing the fatty acid and the aqueous solution of triethanolamine, performing saponification, adding the remaning substances according to the formula proportion, mixing uniformly, and subpackaging into bottles with special devices to prepare the finished products. The sterilizing foaming agent is convenient to use, has wide coating range in the vagina and quick response, and can cure gynecological vaginal inflammation quickly and completely.
Description
Technical field
The present invention relates to a kind of gynaecologic vaginal with antibacterial and preparation method thereof, especially a kind of ability produces foamy vagina with antibacterial and preparation method thereof.
Background technology
Vaginitis, cervicitis are the common diseases of gynecological's outpatient service.Normal health women learns and the biochemistry characteristics owing to separate to dig, and vagina has the nature defense function to the invasion of pathogen, is destroyed when natural defense function, makes pathogen be easy to invade, and causes colpitis.Some female friends are also arranged through simple therapy, just stop treatment after the doing well,improving, do not show effect because pathogen is utterly destroyed to cause repeatedly.Gynecological inflammation is easy to further develop as thoroughly not treating, and causes more serious consequence, even threat to life safety.Cause the main pathogenic bacteria of these gynecological inflammations that staphylococcus, streptococcus, candidiasis etc. are arranged.
The medicine of gynecological inflammations such as treatment vaginitis and cervicitis is divided into for oral administration and external at present.Oral medicine comprises capsule, tablet etc., and medicine for external use is main with built-in suppository, tablet, and the use of most of suppositorys, tablet is inconvenient, is prone to cause foreign body sensation, and the damage vagina.This dosage form contains antibiotic such as metronidazole more, too much uses the balance of destroying vaginal microbial flora easily, makes disease more be prone to outbreak repeatedly.And when using suppository, suppository melts the back and is prone to flow out vagina, causes drug loss, and suppository has process softening, that melt, so medicine can not discharge fully in the short time, and the drug effect performance is slow, and skewness, and therapeutic effect is not obvious.
The V80 trade name is prone to admire can; It is the disinfectant of German GRAJECKI company development and production; The IQ of European Union authentication; Through the wide spectrum of Ministry of Health of the People's Republic of China's approval of import, efficient, environment-friendly type disinfectant, reach the disinfectant of " People's Republic of China's law on the prevention and control of infectious diseases " and " Regulations of sterilization management " standard-required simultaneously.The V80 disinfectant contains materials such as hexamethylenamine, compound quaternary ammonium salt, chelating agen, surfactant, compound aldehydes, active factors; Colourless, tasteless, nontoxic, non-stimulated, the no burn into noresidue of this product, non-volatile has characteristics such as bactericidal range is wide, stable in properties, length of antibacterial phase.
Summary of the invention
The technical problem that the present invention mainly solves provides a kind of antibacterial foam of treating the gynaecologic vaginal infection and preparation method thereof, and this antibacterial foam is easy to use, and is wide, rapid-action in the intravaginal coating, can thoroughly cure the gynaecologic vaginal inflammation fast.
For solving the problems of the technologies described above, the technical scheme that the present invention taked is:
A kind of vagina of the present invention comprises following substances according to the mass fraction with the antibacterial foam: antibacterial 0.1 ~ 0.3, fatty acid 32.0 ~ 38.0, cocoanut fatty acid diethanolamide 2.8 ~ 5.0, lecithin 1.5 ~ 2.5, glycerol 9.5 ~ 10.5, triethanolamine 7.0 ~ 9.5, menthol 0.1, deionized water 30 ~ 50.
Further improvement of the present invention is: said fatty acid is palmitic acid and coco-nut oil fatty acid.
Further improvement of the present invention is: each material of said antibacterial foam is done following proportioning according to mass fraction: antibacterial 2.0 ~ 3.0, palmitic acid 25.0 ~ 30.0, coco-nut oil fatty acid 7.5 ~ 8.0, cocoanut fatty acid diethanolamide 2.8 ~ 3.2, lecithin 2.0, glycerol 10, triethanolamine 8.0 ~ 9.17, menthol 0.1, deionized water 35 ~ 40.
Further improvement of the present invention is: said antibacterial is the wherein a kind of of V80 or single double-stranded compound quaternary ammonium salt.
The present invention also provides the method for preparing of a kind of described vagina with the antibacterial foam, and preparation process is following:
A, take by weighing a certain amount of fatty acid in proportion, under stirring condition, be heated to 60～70 ℃, fuse solution a;
B, take by weighing a certain amount of triethanolamine in proportion, be added in the deionized water of formula ratio, the aqueous solution b of triethanolamine;
C, solution a and solution b are fully mixed, carry out saponification, under stirring condition, add cocoanut fatty acid diethanolamide, antibacterial, glycerol, lecithin, menthol then, mix homogeneously, mixed solution c;
Add deionized water under D, the room temperature and regulate viscosity to 140 ~ 180cP of mixed solution c, be sub-packed in 200 ~ 500ml and fill low-boiling point gas or have in the bottle of manual foam-making apparatus.
Owing to adopted technique scheme, the technological progress that the present invention obtained is: the vagina of the present invention's preparation is reasonable with the antibacterial foam formulation, and method for preparing is correct; Use is convenient; Wide, rapid-action in the intravaginal coating, can thoroughly cure the gynaecologic vaginal inflammation fast.Therefore be a kind of safety, gynaecologic vaginal is used antibacterial efficiently.
Contain V80 or wherein a kind of antibacterial of single double-stranded compound quaternary ammonium salt in the vagina antibacterial foam of the present invention, these two kinds of antibacterial can effectively be killed various antibacterials, fungus, virus fast, and to human non-toxic, non-stimulated.Fatty acid in the antibacterial foam and alkaline agent triethanolamine carry out saponification; Generate soap base soap, this soap base soap in use can produce a large amount of foams, makes antibacterial at vagina cavity uniform distribution; And can effectively infiltrate the vaginal mucosa pleat; Drug effect is fast, coating is wide, has improved the utilization rate and the germicidal efficiency of antibacterial, thereby reaches the purpose of thoroughly curing gynecological inflammation fast.
The glycerol that contains in the antibacterial foam of the present invention can play lubrication, and cocoanut fatty acid diethanolamide plays the effect of stable foam, emulsifier lecithin, and menthol is extracted by natural materials, safety non-toxic.The equal character of above-mentioned each composition is gentle, does not almost stimulate.
The specific embodiment
Below in conjunction with embodiment the present invention is explained further details.
Embodiment 1
Prescription: antibacterial V80 1g, palmitic acid 257g, coco-nut oil fatty acid 75g, cocoanut fatty acid diethanolamide 28g, lecithin 20g, glycerol 100g, triethanolamine 80g, menthol 1g, deionized water 438g.
Method for preparing:
A, take by weighing palmitic acid by formula ratio, coco-nut oil fatty acid is heated to 60～70 ℃ under stirring condition, fuse mixed solution a;
B, join the triethanolamine that takes by weighing by formula ratio in the deionized water, fully stir the aqueous solution b of triethanolamine;
C, mix stirring to solution a, b, carry out saponification, press formula ratio in the whipping process and add cocoanut fatty acid diethanolamide, glycerol and lecithin, menthol and antibacterial V80 continue to stir and make its mixed and dispersed even, must mixed solution c;
D, at room temperature add viscosity to 140 ~ 180cP that deionized water is regulated mixed solution c, be sub-packed in the bottle that has manual foam-making apparatus of 200～500ml.
Embodiment 2
Prescription: the double-stranded compound quaternary ammonium salt 2g of antibacterial list, palmitic acid 270g, coco-nut oil fatty acid 78g, cocoanut fatty acid diethanolamide 30g, lecithin 20g, glycerol 100g, triethanolamine 85g, menthol 1g, deionized water 414g.
Method for preparing is with embodiment 1.
Embodiment 3
Prescription: antibacterial V80 3g, palmitic acid 300g, coco-nut oil fatty acid 75g, cocoanut fatty acid diethanolamide 50g, lecithin 15g, glycerol 95g, triethanolamine 95g, menthol 1g, deionized water 480g.
Method for preparing is with embodiment 1.
Embodiment 4
Prescription: the double-stranded compound quaternary ammonium salt class of antibacterial list 1g, palmitic acid 270g, coco-nut oil fatty acid 80g, cocoanut fatty acid diethanolamide 32g, lecithin 25g, glycerol 105g, triethanolamine 70g, menthol 1g, deionized water 430g.
Method for preparing is with embodiment 1.
Claims (5)
1. a vagina is used the antibacterial foam, it is characterized in that this antibacterial foam comprises following substances according to the mass fraction: antibacterial 0.1 ~ 0.3, fatty acid 32.0 ~ 38.0, cocoanut fatty acid diethanolamide 2.8 ~ 5.0, lecithin 1.5 ~ 2.5, glycerol 9.5 ~ 10.5, triethanolamine 7.0 ~ 9.5, menthol 0.1, deionized water 30 ~ 50.
2. vagina according to claim 1 is used the antibacterial foam, it is characterized in that: said fatty acid is palmitic acid and coco-nut oil fatty acid.
3. vagina according to claim 2 is used the antibacterial foam, it is characterized in that: each material of said antibacterial foam is done following proportioning according to mass fraction: antibacterial 2.0 ~ 3.0, palmitic acid 25.0 ~ 30.0, coco-nut oil fatty acid 7.5 ~ 8.0, cocoanut fatty acid diethanolamide 2.8 ~ 3.2, lecithin 2.0, glycerol 10, triethanolamine 8.0 ~ 9.17, menthol 0.1, deionized water 35 ~ 40.
4. use the antibacterial foam according to each described vagina of claim 1～3, it is characterized in that: said antibacterial is the wherein a kind of of V80 or single double-stranded compound quaternary ammonium salt.
5. a vagina is characterized in that comprising the steps: with the method for preparing of antibacterial foam
A, take by weighing a certain amount of fatty acid in proportion, under stirring condition, be heated to 60～70 ℃, fuse solution a;
B, take by weighing a certain amount of triethanolamine in proportion, be added in the deionized water of formula ratio, the aqueous solution b of triethanolamine;
C, solution a and solution b are fully mixed, under stirring condition, add cocoanut fatty acid diethanolamide, antibacterial, glycerol, lecithin, menthol then, mix homogeneously, mixed solution c;
Add deionized water under D, the room temperature and regulate viscosity to 140 ~ 180cP of mixed solution c, be sub-packed in 200 ~ 500ml and fill low-boiling point gas or have in the bottle of manual foam-making apparatus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201210105854 CN102614124B (en) | 2012-04-12 | 2012-04-12 | Vaginal sterilizing foaming agent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201210105854 CN102614124B (en) | 2012-04-12 | 2012-04-12 | Vaginal sterilizing foaming agent and preparation method thereof |
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| CN102614124A true CN102614124A (en) | 2012-08-01 |
| CN102614124B CN102614124B (en) | 2013-08-21 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
| CN105687027A (en) * | 2016-01-26 | 2016-06-22 | 中国科学院生物物理研究所 | Alcohol-free amino acid type rinse-free foam washing solution |
| CN109481395A (en) * | 2018-12-24 | 2019-03-19 | 刘长德 | A kind of foam filling paste and application for preventing and treating domestic animal hoof disease |
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| CN1857243A (en) * | 2006-03-10 | 2006-11-08 | 贵州宏宇药业有限公司 | Vaginal foam preparation of chlorhexidine acetate and its preparing process |
| CN101032470A (en) * | 2007-04-21 | 2007-09-12 | 郑起平 | Povidone-iodine bubble agent and preparing method |
| CN101066409A (en) * | 2007-05-25 | 2007-11-07 | 广州中医药大学 | Medicine composition for killing sperm and treating vaginitis |
| US20070280891A1 (en) * | 2003-08-04 | 2007-12-06 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
-
2012
- 2012-04-12 CN CN 201210105854 patent/CN102614124B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070280891A1 (en) * | 2003-08-04 | 2007-12-06 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| CN1857243A (en) * | 2006-03-10 | 2006-11-08 | 贵州宏宇药业有限公司 | Vaginal foam preparation of chlorhexidine acetate and its preparing process |
| CN101032470A (en) * | 2007-04-21 | 2007-09-12 | 郑起平 | Povidone-iodine bubble agent and preparing method |
| CN101066409A (en) * | 2007-05-25 | 2007-11-07 | 广州中医药大学 | Medicine composition for killing sperm and treating vaginitis |
| CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
Non-Patent Citations (1)
| Title |
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| 蒋国民: "《气雾剂理论与技术》", 31 January 2011, article "抛射剂的用量", pages: 1130-1138 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
| CN105687027A (en) * | 2016-01-26 | 2016-06-22 | 中国科学院生物物理研究所 | Alcohol-free amino acid type rinse-free foam washing solution |
| CN109481395A (en) * | 2018-12-24 | 2019-03-19 | 刘长德 | A kind of foam filling paste and application for preventing and treating domestic animal hoof disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102614124B (en) | 2013-08-21 |
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