Background technology
Plant the tooth technology and had more than 20 year with using in Research in China; Domestic implantation body remains naked titanium and adds sandblast; China was subsidized by the Chinese Natural Science Foundation before 24 years; Former Sichuan University, former West China medical college and photoelectricity institute are studied active artificial bone hydroxyapatite (HA) and biological glass ceramic (BGC) success.And be tested and appraised in JIUYUE, 1986, reach advanced world standards, obtained Chinese Academy of Sciences's first prize, combine not firmly because of substrate at last by West China medical college veto by one vote, the inanimate object active material uses on Chinese Dental Implant more even to this day.
The surface active material processing method has in the world: (1) coating sintering method; (2) plasma spraying method; (3) laser melts and attaches method; (4) ion beam assisted depositing method; (5) electrophoretic deposition; (6) anodizing etc.All be because the fusing point of titanium more than 1550 °, wants to cement admittedly, necessary high temperature, high temperature causes chemical reaction, the hydroxyl degeneration, degree of crystallinity reduces, and perhaps material fragility increases, and the substrate be full of cracks has influenced practical function, can not get clinical sure.
Summary of the invention
The objective of the invention is to work out a kind of firm with implantation body's titanium and titanium sand sintering; Let bone conduction material activity artificial bone not receive temperatures involved again, be anchored in the titanium valve hole, add bone induction material simultaneously; Promote osteocyte and implantation body to adhere in early days, breed, thereby form synosteosis quickly.
Technical scheme of the present invention:
At surfaces coated one deck 0.02-0.08mm of titanium spiral-shafted implant titanium slurry, wait to do solid final vacuum sintering, forbid to burn molten point, make its sintering firm, there is hole to interconnect between the titanium sand.And after annealing does not become fragile material.
The water mill that adds the material of bone conduction material artificial bone hydroxyapatite and so on 20-30% becomes screened stock; Adopt vacuum grouting process to fill titanium sand hole crack, low-temperature sintering becomes solid again, perhaps the electrophoretic deposition artificial bone; It is solid in hole to let artificial bone tie, and is anchored between titanium sand to be interconnected.
Pouring into the also surface of the implantation body of low-temperature sintering artificial bone, repaste covers one deck has the bone of bone-inducing factor to induce the dawn white, and lyophilizing cold preservation is subsequent use, or before clinical use, attaches use with being rich in platelet blood plasma bag, thereby form synosteosis faster.Platelet is the natural origin of somatomedin, obtains easily.
Implantation body of the present invention titanium and titanium sand sintering are firm, and vacuum pours into the inorganic artificial bone of biologically active in this firm substrate, are anchored in the titanium sand hole crack through low-temperature sintering; Repaste attaches one deck, and to have bone formation dawn of bone inducement son white; Promote that osteocyte adheres in early days, breeds, thereby form synosteosis quickly, make interface synosteosis rate higher; Tiltedly synosteosis and gingiva close attachment are arranged the shoulder place at the flat alveolar ridge of implant neck; Can strengthen the resistance of periodontal, reduce the absorption of alveolar bone and gingiva, become aesthstic implantation body.
The inventive method is easy, has avoided the influence of high temperature to material, the hydroxyl degeneration, and degree of crystallinity reduces, and material becomes fragile and the substrate be full of cracks is peeled off etc., and this law does not need special installation, and cost is low, easy production in batch.
The specific embodiment
Embodiment 1
Mix (ratio of titanium valve and dextrin 1 to 1) with 30 μ m-40 μ m titanium valves and dextrin, evenly be sprayed in the titanium helical form implantation body, THICKNESS CONTROL is between 0.02-0.05mm; Move in the Zirconium oxide sintering stove that dentistry is used always negative 2 atmospheric pressure, vacuum-sintering after waiting to do admittedly; Temperature is controlled between 1000-1200 ℃, annealing in process thereafter, the multiple original toughness of titanium ash that lets the sintering hardening become fragile; Detect and whether bond firmly; Whether hole conforms to requirement (hole 2-15 μ m, the hole of 1-3 layer phase intercommunication), otherwise reburns once by last method repaste.
Artificial bone is a trade name, and wherein hydroxyapatite is the most frequently used.Buy the nano-grade hydroxy apatite powder and get final product, add 20% water furnishing slurry; Oneself mill requires granularity at 1-3 μ m, and priming by vacuum is in the firm sand hole of the titanium layer by layer crack of bonding.Artificial bone is selected hydroxyapatite (HA) for use, and market is on sale.After implant surface sintering titanium valve, put into the hydroxyapatite mortar, air is arranged in the pore between the titanium valve; Formed bubble, the artificial bone mortar is impenetrable, must be together with mortar and implantation body's evacuation; Take bubble away, negative two atmospheric pressure lean on atmospheric pressure to compress into mortar.In the low-temperature sintering anchoring, temperature is controlled at 200 ℃ to 250 ℃ again.Avoid artificial bone chemically reactive at high temperature, the hydroxyl degeneration, degree of crystallinity worker reduces or substrate separates or the like.
Artificial bone material implant surface repaste covers one deck bone formation dawn white (BMP) irritating well, and lyophilizing cold preservation is subsequent use.
Can promote that like this osteocyte adheres in early days, breeds; Quickly and synosteosis; Make bone interface combination rate higher, synosteosis also arranged at the oblique shoulder place of the flat alveolar ridge of the cervical region of implantation body, gingiva to bone just adhere to closely can prevention of bacterial erosion; Strengthen periodontal resistance and the absorption that reduces alveolar bone and gingiva, become aesthstic implantation body.
Embodiment 2
Mix (ratio of titanium valve and dextrin 1 to 1) with 30 μ m-40 μ m titanium valves and dextrin, evenly be sprayed in the titanium helical form implantation body, THICKNESS CONTROL is between 0.05-0.08mm; Move in the Zirconium oxide sintering stove that dentistry is used always negative 2 atmospheric pressure, vacuum-sintering after waiting to do admittedly; Temperature is controlled between 1400-1500 ℃, annealing in process thereafter, the multiple original toughness of titanium ash that lets the sintering hardening become fragile; Detect and whether bond firmly; Whether hole conforms to requirement (hole 2-15 μ m, the hole of 1-3 layer phase intercommunication), otherwise reburns once by last method repaste.
Artificial bone is selected biological glass ceramic (BGC) for use, and market is on sale, adds 30% water furnishing slurry.After implant surface sintering titanium valve, put into mortar, air is arranged in the pore between the titanium valve; Formed bubble, the artificial bone mortar is impenetrable, must be together with mortar and implantation body's evacuation; Take bubble away, negative two atmospheric pressure lean on atmospheric pressure to compress into mortar.In the low-temperature sintering anchoring, temperature is controlled at 400 ℃ to 500 ℃, or the electrophoretic deposition artificial bone again.Avoid artificial bone chemically reactive at high temperature, the hydroxyl degeneration, degree of crystallinity worker reduces or substrate separates or the like.
Artificial bone material implant surface repaste covers one deck bone formation dawn white (BMP) irritating well, is rich in platelet blood plasma with the centrifuge preparation before using clinically and uses at once.(PRP) platelet is the natural origin of somatomedin, produces easily.
Embodiment 3
Mix (ratio of titanium valve and dextrin 1 to 1) with 30 μ m-40 μ m titanium valves and dextrin, evenly be sprayed in the titanium helical form implantation body, THICKNESS CONTROL is between 0.02-0.08mm; Move in the Zirconium oxide sintering stove that dentistry is used always negative 2 atmospheric pressure, vacuum-sintering after waiting to do admittedly; Temperature is controlled between 1200-1300 ℃, annealing in process thereafter, the multiple original toughness of titanium ash that lets the sintering hardening become fragile; Detect and whether bond firmly; Whether hole conforms to requirement (hole 2-15 μ m, the hole of 1-3 layer phase intercommunication), otherwise reburns once by last method repaste.
Artificial bone selects for use calcium triphosphate (TCP) market on sale, adds 25% water furnishing slurry.After implant surface sintering titanium valve, put into mortar, air is arranged in the pore between the titanium valve; Formed bubble, the artificial bone mortar is impenetrable, must be together with mortar and implantation body's evacuation; Take bubble away, negative two atmospheric pressure lean on atmospheric pressure to compress into mortar.In the low-temperature sintering anchoring, temperature is controlled at 300 ℃ to 350 ℃, or the electrophoretic deposition artificial bone again.
Artificial bone material implant surface repaste covers one deck bone formation dawn white (BMP) irritating well, and lyophilizing cold preservation is subsequent use.