CN102641554A - Feedback type nerve electric stimulation system with in vitro sleep detection device and feedback type nerve electric stimulation method - Google Patents

Feedback type nerve electric stimulation system with in vitro sleep detection device and feedback type nerve electric stimulation method Download PDF

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CN102641554A
CN102641554A CN2011100420945A CN201110042094A CN102641554A CN 102641554 A CN102641554 A CN 102641554A CN 2011100420945 A CN2011100420945 A CN 2011100420945A CN 201110042094 A CN201110042094 A CN 201110042094A CN 102641554 A CN102641554 A CN 102641554A
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patient
electric stimulation
sleep
signal
pulse generator
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尉敏
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Suzhou Jingyu Medical Equipment Co Ltd
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Suzhou Jingyu Medical Equipment Co Ltd
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Abstract

The invention discloses a feedback type nerve electric stimulation system with an in vitro sleep detection device. The feedback type nerve electric stimulation system comprises a pulse generator, an electrode and the in vitro sleep detection device, wherein the electrode is connected with the pulse generator, the in vitro sleep detection device is used for judging whether patients are in the deep sleeping state or not, when the in vitro sleep detection device judges that the patients are in the deep sleeping state, and control signals are sent to the pulse generator by the in vitro sleep detection device or through a patient controller so that the pulse generator automatically weakens or stops the pulse signal output, so the feedback type automatic regulation of the output pulse signals of the pulse generator is realized, the power consumption wasted because the stimulation can be completely stopped through the symptom relief or elimination at night in the heavy sleep state of the patients with movement disorders, parkinsonism and the like, the service life of the nerve electric stimulation system is greatly prolonged, and the economic load born by the patients is reduced.

Description

Reaction type nerve electric stimulation system and method with external sleep detection apparatus
Technical field
The present invention relates to the implantable nerve electric stimulation, especially a kind of can be according to whether being in reaction type nerve electric stimulation system and the feedback thereof that deep sleep is regulated output automatically.
Background technology
Nerve electric stimulation has important effect in maladjusted nervous system treatment and nerve injury rehabilitation.The implantable nerve electric stimulation through in human body such as nervus motorius, sensorineural specific neural place implant electrode, discharge high-frequency electrical stimulation, so that specific nerve is stimulated, thereby make function of human body return to the state of normal operation.
At present; The implantable nerve electric stimulation mainly comprises and is used to treat the implanted brain deep electricity irritation (DBS with typical motion obstruction type diseases such as parkinson disease; Be commonly called as brain pacemaker), implanted cortex electricity irritation (CNS), implanted spinal cord stimulation trial system (SCS); Implanted sacral nerves electric stimulation (SNS), implanted vagus nerve electric stimulation (VNS) or the like.
Known implantable nerve electric stimulation mainly comprises pulse generator, electrode, extension wire and control device usually.Wherein, pulse generator is connected with extension wire, extension wire and then be connected to electrode again, thereby with burst transmissions that pulse generator produced to electrode, so that nerve is carried out electricity irritation.
Nerve electric stimulation system does not in the market all have feedback control function automatically.With the brain pacemaker is example, and its impulse stimulation output relies on the predefined formula of doctor fully and carries out open loop control.Many cases clinical medicine data show that can alleviate or eliminate by symptom when sleeping soundly night for dyskinetic disease patient (especially parkinson patient), originally can stop fully stimulating to reduce pacemaker unnecessary power consumption when night, patient slept soundly.And existing system for want of detects and feedback automatically, stimulation can not be provided automatically as required, thereby waste the suitable energy content of battery, and the life-span of pacemaker is had a greatly reduced quality.
In order to address the above problem, to have occurred dependence patient itself in the prior art and reached " as required " and stimulate and then reach the method for purpose of saving through using Magnet or patient's controller that pacemaker is initiatively carried out on-off control.Yet these means obviously can only could effectively be used when patient is in waking state, can't operate when sleeping soundly.
In addition, another measure is to set set time in night section (as sleeping soundly the time period) by the doctor to shut down function automatically to reach purpose of saving.But this method supposition patient daily life is rule very, lacks motility, just in case patient gets up and go to toilet or wake up for some reason midnight, and pacemaker is in off-mode, then can bring beyond thought trouble to patient.
Chinese patent 200580031533.5 is employed in patient an acceleration movement pick off is installed on one's body in addition; System judges through this motion perceptron whether patient is in morbidity state and then regulates stimulating output to carry out switch, has increased extra awareness tool and is not that closed loop is controlled automatically.
Summary of the invention
To the deficiency that exists in the prior art, the technical problem that the present invention will solve provides a kind ofly utilizes external sleep detection apparatus to judge whether patient is in the deep sleep and the automatic reaction type nerve electric stimulation system of the output pulse signal of regulating impulse generator as required.
According to a kind of technical scheme provided by the present invention; A kind of reaction type nerve electric stimulation system with external sleep detection apparatus; Comprise pulse generator, the electrode that is connected with said pulse generator; This system also comprises and is used to judge whether patient is in the external sleep detection apparatus of deep sleep; Said external sleep detection apparatus judges when patient is in deep sleep, and said external sleep detection apparatus sends to pulse generator that control signal weakens automatically or the output pulse signal of stop pulse generator.
Preferably, said external sleep detection apparatus comprises: the eeg signal acquisition module is used to gather patient's eeg signal; Processing and control module; The input of said processing and control module is connected with the outfan of said eeg signal acquisition module; Said processing and control module is used for the eeg signal that the eeg signal acquisition module collects is handled and judged whether this patient is in deep sleep, and when patient is in deep sleep, sends the control signal that weakens automatically or stop to export pulse to pulse generator;
Wireless communication module, the input of said wireless communication module is connected with the outfan of said processing and control module, is used for and described pulse generator two-way wireless communication.
Preferably; Said processing and control module comprises signal condition unit, A/D converting unit, signal processing unit, output control unit, and the eeg signal that is used for said eeg signal acquisition module is collected is handled and judged whether this patient is in deep sleep through said units successively.
Preferably, said external sleep detection apparatus comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's eeg signal.During use, only need patient before sleep, to put on headgear and get final product, need not operation and implant that scalp is safe in utilization, convenient, price is lower, thereby and can monitor patient's sleep state raising sleep quality.
Preferably, said reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation.
According to another kind of technical scheme provided by the present invention; A kind of reaction type nerve electric stimulation system with external sleep detection apparatus; Comprise pulse generator, the electrode that is connected with said pulse generator; This system also comprises and is used to judge whether patient is in the external sleep detection apparatus of deep sleep; Said external sleep detection apparatus judges when patient is in deep sleep, and said external sleep detection apparatus sends to pulse generator that control signal weakens automatically or the output pulse signal of stop pulse generator.
Preferably, said external sleep detection apparatus comprises: the eeg signal acquisition module is used to gather patient's eeg signal; Processing and control module; The input of said processing and control module is connected with the outfan of said eeg signal acquisition module; Said processing and control module is used for the eeg signal that the eeg signal acquisition module collects is handled and judged whether this patient is in deep sleep, and when patient is in deep sleep, sends the control signal that weakens automatically or stop to export pulse to pulse generator;
Wireless communication module, the input of said wireless communication module is connected with the outfan of said processing and control module, is used for and described pulse generator two-way wireless communication.
Preferably; Said processing and control module comprises signal condition unit, A/D converting unit, signal processing unit, output control unit, and the eeg signal that is used for said eeg signal acquisition module is collected is handled and judged whether this patient is in deep sleep through said units successively.
Preferably, said external sleep detection apparatus comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's eeg signal.During use, only need patient before sleep, to put on headgear and get final product, need not operation and implant that scalp is safe in utilization, convenient, price is lower, thereby and can monitor patient's sleep state raising sleep quality.
Preferably, said reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation.
According to another kind of technical scheme provided by the present invention; A kind of reaction type nerve electric stimulation system with external sleep detection apparatus; Patient's controller of the output parameter that comprise pulse generator, the electrode that is connected with said pulse generator, is used for the said pulse generator of regulating and controlling; This system also comprises the external sleep characteristics harvester that is used to gather patient deep sleep characteristic; Said external sleep characteristics harvester is connected with patient's controller; The sleep characteristics signal that processing and control module in said patient's controller collects external sleep characteristics harvester is handled and is judged whether this patient is in deep sleep; Said patient's controller judges when patient is in deep sleep, and said patient's controller sends to pulse generator that control signal weakens automatically or the output pulse signal of stop pulse generator.
Preferably; The power supply that is provided with processing and control module, wireless communication module in said patient's controller and supplies power for unit module; Said processing and control module comprises and is used for signal amplifying signal conditioning unit, is used for analog-to-digital A/D converting unit, is used for signal processing unit, output control unit that signal filtering is handled and judged, and the sleep characteristics signal that said processing and control module collects external sleep characteristics harvester is handled and judged whether this patient is in deep sleep through said units successively.
With the difference of technique scheme be; Processing and control module in this scheme is arranged in the existing supporting patient's controller of patient, and wireless telecommunications or other communication modes set up through patient's controller and pulse generator send the control signal of automatic regulating impulse output to pulse generator.The patient's controller that has utilized patient to be equipped with, the automatic feedback that need not when increase equipment can be realized sleeping is in addition regulated as required.
Preferably, said external sleep characteristics harvester comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's brain wave.
Preferably, said reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation.
Another technical problem that the present invention will solve provides a kind of feedback that can regulate the implantable nerve electric stimulation that stimulates output as required automatically, comprises the steps:
A: outside the patient body installing be used to gather patient deep sleep characteristic the sleep characteristics acquisition module, be used for the sleep characteristics signal that collects is handled and judged whether this patient is in the processing and control module of deep sleep;
B: the signal that said sleep characteristics acquisition module is collected is sent to said processing and control module, and said processing and control module is handled this signal and judged whether patient is in deep sleep;
C: when said processing and control module was judged patient and is in deep sleep, said processing and control module sent to the pulse generator of implanting that control signal weakens automatically or the output pulse signal of stop pulse generator.
Preferably, described sleep characteristics acquisition module comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's brain wave.
Preferably; Said processing and control module be arranged on can with patient's controller of pulse generator wireless telecommunications in; Said scalp electrode is connected with patient's controller and patient's eeg signal is sent to the processing and control module of patient's controller, and said processing and control module is sent to said control signal in the pulse generator through wireless communication module.
Compared with prior art; Advantage of the present invention is: in being arranged on external sleep detection apparatus or the processing and control module in patient's controller when having judged patient and being in deep sleep; To send to pulse generator and weaken automatically or the control signal of stop pulse output; Thereby realize the output pulse signal of the automatic regulating impulse generator of reaction type; Reduced patients such as dyskinetic disease, parkinson when sleeping soundly night because of remission or eliminate and originally can stop to stimulate the power consumption of waste fully, thereby prolonged the service life of nerve electric stimulation system greatly, alleviated the financial burden that patient bears.
Description of drawings
Accompanying drawing 1 is the theory diagram of first kind of specific embodiment of the present invention;
Accompanying drawing 2 is the theory diagram of second kind of specific embodiment of the present invention;
Accompanying drawing 3 is the functional module schematic diagram of first kind of specific embodiment of the present invention;
Accompanying drawing 4 is the functional module schematic diagram of second kind of specific embodiment of the present invention;
Accompanying drawing 5 is the flow chart of feedback of the present invention;
Accompanying drawing 6 is the program flow diagram of feedback of the present invention;
Wherein:
1, pulse generator; 2, external sleep detection apparatus; 21, eeg signal acquisition module; 22, processing and control module; 221, signal condition unit; 222, A/D converting unit; 223, signal processing unit; 224, output control unit; 23, wireless communication module; 3, electrode; 4, electrode is selected control unit; 41, processing and control module; 411, signal condition unit; 412, A/D converting unit; 413, signal processing unit; 414, output control unit; 42, wireless communication module; 5, external sleep characteristics harvester.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is done further detailed explanation:
Embodiment one:
With reference to Fig. 1; A kind of reaction type nerve electric stimulation system with external sleep detection apparatus; Comprise the intravital pulse generator of implant patient 1, the electrode 3 that is connected with said pulse generator 1, and be used to judge whether patient is in the external sleep detection apparatus 2 of deep sleep.Pulse generator 1 is electrically connected with electrode 3, thereby the burst transmissions that pulse generator 1 is produced is arrived electrode 3, so that neuronal target is carried out electricity irritation, reaches the effect of diseases such as the treatment dyskinesia, parkinson.
When external sleep detection apparatus 2 is judged patient and is in deep sleep; External sleep detection apparatus 2 is sent control signal to pulse generator 1; Make pulse generator 1 weaken or stop output pulse signal automatically; Realized regulating as required, reduced the unnecessary power consumption when night, patient slept soundly.Perhaps; This pulse generator 1 is provided with at least two kinds of stimulus modelities; A kind of is conventional stimulus modelity; A kind of is that output weakens or export the sleep stimulus modelity that stops, and automatic regulating impulse generator to the stimulus modelity of sleeping is with the minimizing power consumption when external sleep detection apparatus 2 is judged patient and is in deep sleep.
With reference to Fig. 3, said external sleep detection apparatus 2 comprises: eeg signal acquisition module 21 is used to gather patient's eeg signal;
Processing and control module 22 and the power supply of supplying power for unit module; The input of said processing and control module 22 is connected with the outfan of said eeg signal acquisition module 21; Said processing and control module 22 comprises signal condition unit 221, A/D converting unit 222, signal processing unit 223, output control unit 224; The eeg signal that eeg signal acquisition module 21 is collected is handled and is judged whether this patient is in deep sleep through said units successively, and when patient is in deep sleep, sends the control signal that weakens automatically or stop to export pulse to pulse generator 1;
Wireless communication module 23, the input of said wireless communication module 23 is connected with the outfan of said processing and control module 22, is used for realizing two-way wireless communication with described pulse generator 1.
Judge these patients when said processing and control module 22 and be in deep sleep following time, said output control unit 224 sends control signal through wireless communication module 23 to pulse generator 1, makes pulse generator 1 weaken or stop output pulse signal automatically.When judged result is patient when not being in deep sleep, said output control unit 224 sends to pulse generator 1 and keeps or recover conventional stimulus modelity control signal.
In the present embodiment, the eeg signal acquisition module 21 of external sleep detection apparatus 2 is for being set in the headgear of patient head, and the inboard of headgear is provided with the scalp electrode that is used to gather eeg signal.During use, only need a patient before sleep, to put on headgear and get final product, need not operation implantation scalp electrode, safe in utilization, convenient, price is lower.And, can also improve sleep quality thereby take corresponding measure to improve according to the brain wave information analysis patient of patient in the memorizer when sleeping sleep state.
This reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation, other implantation type electric stimulation systems that need not to stimulate when also can be applicable to deep sleep certainly.
Embodiment two:
With reference to Fig. 2; A kind of reaction type nerve electric stimulation system with external sleep detection apparatus; Comprise pulse generator 1, the electrode 3 that is connected with said pulse generator 1, the patient's controller 4 that is used for the output parameter of the said pulse generator 1 of regulating and controlling, and be used to gather the external sleep characteristics harvester 5 of patient deep sleep characteristic.Be provided with the processing and control module 41 that signal that external sleep characteristics harvester 5 is gathered is handled in patient's controller 4, the wireless communication modules 42 in patient's controller 4 can be realized the two-way communication with pulse generator 1.
With the difference of embodiment one be; Processing and control module 41 among this embodiment is arranged in the existing supporting patient's controller 4 of patient, and wireless telecommunications or other communication modes set up through patient's controller 4 and pulse generator 1 send the control signal of automatic regulating impulse output to pulse generator 1.Before use, only need patient's controller 4 is connected with external sleep characteristics harvester 5, the patient's controller that has utilized patient to be equipped with fully need not the adjusting as required when increase equipment can be realized sleeping in addition.
With reference to Fig. 4; External sleep characteristics harvester 5 is connected with patient's controller 4; The power supply that is provided with processing and control module 41, wireless communication module 42 in patient's controller 4 and supplies power for unit module; Processing and control module 41 comprises and is used for signal amplifying signal conditioning unit 411, is used for analog-to-digital A/D converting unit 412, is used for signal processing unit 413, output control unit 414 that signal filtering is handled and judged; The sleep characteristics signal that 41 pairs of external sleep characteristics harvesters 5 of processing and control module collect is handled and is judged whether this patient is in deep sleep through said units successively; When processing and control module 41 judges that patient is in deep sleep; The output control unit 414 of said patient's controller 4 sends control signal through wireless communication module 42 to pulse generator with control signal, makes pulse generator 1 weaken or stop output pulse signal automatically.
In the present embodiment, external sleep characteristics harvester 5 is for being set in the headgear of patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's brain wave.During use, only need a patient before sleep, to put on headgear and get final product, need not operation implantation scalp electrode, safe in utilization, convenient, price is lower.And, can also be the sleep state that diagnosis provides a large amount of valuable diagnostic messages and analyzes patient according to patient's in the memorizer brain wave information, improve sleep quality thereby take corresponding measure to improve.
Reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation, other implantation type electric stimulation systems that need not to stimulate when also can be applicable to deep sleep certainly.
With reference to Fig. 5 and Fig. 6,, comprise the steps: for using the method for feedback control implantable nerve electric stimulation output of the present invention
A: outside the patient body installing be used to gather patient deep sleep characteristic the sleep characteristics acquisition module, be used for the sleep characteristics signal that collects is handled and judged whether this patient is in the processing and control module of deep sleep;
B: the signal that said sleep characteristics acquisition module is collected is sent to said processing and control module, and said processing and control module is handled this signal and judged whether patient is in deep sleep;
C: when said processing and control module was judged patient and is in deep sleep, said processing and control module sent to the pulse generator of implanting that control signal weakens automatically or the output pulse signal of stop pulse generator.
When judged result is patient when not being in deep sleep, external processing and control module is sent to pulse generator and is kept or recover conventional stimulus modelity control signal.
As patient owing to get up in the night to urinate or stand up action when getting into non-deep sleep again by deep sleep; Said processing and control module will be sent to pulse generator again and recover conventional stimulus modelity control signal; The output that makes pulse generator is weakened or halted state returns to again under the conventional stimulus modelity by original, has avoided the situation of impulsing generator shutdown when patient has stimulation to need.
Wherein, the sleep characteristics acquisition module comprises the headgear that is set in patient head, and the inboard of headgear is provided with the scalp electrode that is used to gather patient's brain wave.Processing and control module can be arranged in patient's controller, and the mode of control signal through wireless telecommunications is sent in the pulse generator; Processing and control module also can become external sleep detection apparatus with the integrated one that is set to of headgear, directly transmits automatic conditioning signal to pulse generator.
This feedback can be applicable to a kind of in implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or the implanted vagus nerve electric stimulation, other implantation type electric stimulation systems that need not to stimulate when also can be applicable to deep sleep certainly.
Above specific embodiments of the invention is described.Be illustrative for description of the invention among this paper, thereby scope of the present invention should not be limited to the above-mentioned specific embodiment.It will be apparent to one skilled in the art that and under the situation that does not break away from purport of the present invention or substitutive characteristics, the above-mentioned specific embodiment is carried out other distortion or change, also should be regarded as protection scope of the present invention.

Claims (12)

1. reaction type nerve electric stimulation system with external sleep detection apparatus; Comprise pulse generator, the electrode that is connected with said pulse generator; It is characterized in that: this system also comprises and is used to judge whether patient is in the external sleep detection apparatus of deep sleep; Said external sleep detection apparatus judges when patient is in deep sleep, and said external sleep detection apparatus sends to pulse generator that control signal weakens automatically or the output pulse signal of stop pulse generator.
2. the reaction type nerve electric stimulation system with external sleep detection apparatus according to claim 1, it is characterized in that: said external sleep detection apparatus comprises:
The eeg signal acquisition module is used to gather patient's eeg signal;
Processing and control module; The input of said processing and control module is connected with the outfan of said eeg signal acquisition module; Said processing and control module is used for the eeg signal that the eeg signal acquisition module collects is handled and judged whether this patient is in deep sleep, and when patient is in deep sleep, sends the control signal that weakens automatically or stop to export pulse to pulse generator;
Wireless communication module, the input of said wireless communication module is connected with the outfan of said processing and control module, is used for and described pulse generator two-way wireless communication.
3. the reaction type nerve electric stimulation system with external sleep detection apparatus according to claim 2; It is characterized in that: said processing and control module comprises signal condition unit, A/D converting unit, signal processing unit, output control unit, and the eeg signal that is used for said eeg signal acquisition module is collected is handled and judged whether this patient is in deep sleep through said units successively.
4. the reaction type nerve electric stimulation system with external sleep detection apparatus according to claim 3; It is characterized in that: said external sleep detection apparatus comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's eeg signal.
5. according to arbitrary described reaction type nerve electric stimulation system with external sleep detection apparatus in the claim 1 to 4, it is characterized in that: said reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation.
6. reaction type nerve electric stimulation system with external sleep detection apparatus; Patient's controller of the output parameter that comprise pulse generator, the electrode that is connected with said pulse generator, is used for the said pulse generator of regulating and controlling; It is characterized in that: this system also comprises the external sleep characteristics harvester that is used to gather patient deep sleep characteristic; Said external sleep characteristics harvester is connected with patient's controller; The sleep characteristics signal that processing and control module in said patient's controller collects external sleep characteristics harvester is handled and is judged whether this patient is in deep sleep; Said patient's controller judges when patient is in deep sleep, and said patient's controller sends to pulse generator that control signal weakens automatically or the output pulse signal of stop pulse generator.
7. the reaction type nerve electric stimulation system with external sleep detection apparatus according to claim 6; It is characterized in that: the power supply that is provided with processing and control module, wireless communication module in said patient's controller and supplies power for unit module; Said processing and control module comprises and is used for signal amplifying signal conditioning unit, is used for analog-to-digital A/D converting unit, is used for signal processing unit, output control unit that signal filtering is handled and judged, and the sleep characteristics signal that said processing and control module collects external sleep characteristics harvester is handled and judged whether this patient is in deep sleep through said units successively.
8. the reaction type nerve electric stimulation system with external sleep detection apparatus according to claim 6; It is characterized in that: said external sleep characteristics harvester comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's brain wave.
9. according to claim 6 or 7 described reaction type nerve electric stimulation systems with external sleep detection apparatus, it is characterized in that: said reaction type nerve electric stimulation system comprises implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerves electric stimulation or implanted vagus nerve electric stimulation.
10. the feedback of an implantable nerve electric stimulation is characterized in that: comprise the steps:
A: outside the patient body installing be used to gather patient deep sleep characteristic the sleep characteristics acquisition module, be used for the sleep characteristics signal that collects is handled and judged whether this patient is in the processing and control module of deep sleep;
B: the signal that said sleep characteristics acquisition module is collected is sent to said processing and control module, and said processing and control module is handled this signal and judged whether patient is in deep sleep;
C: when said processing and control module was judged patient and is in deep sleep, said processing and control module sent to the pulse generator of implanting that control signal weakens automatically or the output pulse signal of stop pulse generator.
11. the feedback of implantable nerve electric stimulation according to claim 10; It is characterized in that: described sleep characteristics acquisition module comprises the headgear that is set in patient head, and the inboard of said headgear is provided with the scalp electrode that is used to gather patient's brain wave.
12. the feedback of implantable nerve electric stimulation according to claim 11; It is characterized in that: said processing and control module be arranged on can with patient's controller of pulse generator wireless telecommunications in; Said scalp electrode is connected with patient's controller and patient's eeg signal is sent to the processing and control module of patient's controller, and said processing and control module is sent to said control signal in the pulse generator through wireless communication module.
CN2011100420945A 2011-02-22 2011-02-22 Feedback type nerve electric stimulation system with in vitro sleep detection device and feedback type nerve electric stimulation method Pending CN102641554A (en)

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CN103137157A (en) * 2013-01-24 2013-06-05 中国联合网络通信集团有限公司 Terminal media play control method, terminal media play control device and terminal
CN108697890A (en) * 2015-12-28 2018-10-23 康维格医疗控股有限公司 It is a kind of to pass through the synchronous system and method for activating the various neurological diseases of Neurotherapeutic
CN108697890B (en) * 2015-12-28 2022-05-27 康维格医疗控股有限公司 System and method for treating various neurological diseases by synchronously activating nerves
CN106512206A (en) * 2016-11-04 2017-03-22 清华大学 Implanted closed-loop brain deep stimulating system
CN106512206B (en) * 2016-11-04 2019-01-04 清华大学 Implanted closed loop deep brain stimulation system
CN106621041A (en) * 2016-12-21 2017-05-10 北京品驰医疗设备有限公司 Configuration system for electronic prescription of vagus nerve stimulator
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CN113546275A (en) * 2021-07-16 2021-10-26 武汉亿迈医疗科技有限公司 Insomnia therapeutic apparatus and waveform modulation method thereof
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