CN102920810B - Mucosa nursing matter for behcet's syndrome - Google Patents
Mucosa nursing matter for behcet's syndrome Download PDFInfo
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Abstract
The invention discloses a mucosa nursing matter for behcet's syndrome, belongs to the medical field of gynecological nursing, and solves the problem of mucosa ulcer of behcet's syndrome. The mucosa nursing matter for behcet's syndrome is characterized in that the mucosa nursing matter for behcet's syndrome is prepared from various traditional Chinese medicines in part by weight as follows: 6-10 parts of ternate buttercup root, 8-15 parts of trichosanthes palmata, 8-15 parts of japanese ardisia stem and leaf, 6-10 parts of poisonous buttercup herb, 6-10 parts of peach gum, 8-15 parts of earthworm, 6-10 parts of beewax, 8-15 parts of Metaplexis japonica Makino, and 3-6 parts of pyrite nodule. Clinical experiments show that the mucosa nursing matter for behcet's syndrome has the characteristics of good curative effect and higher safety, and is worth applying clinically and popularizing.
Description
Technical field
The present invention relates to gynecological's nursing medical field, be specifically related to a kind of mucomembranous nursing thing for Behcet's syndrome.
Background technology
Behcet's syndrome (Behcet ' s disease, BD) be a kind of general, chronic, vasculitic disease.Be outstanding behaviours with oral ulcer, genital ulcer, ophthalmia and skin lesion clinically, be called ophthalmoorogenital syndrome (behcet syndrome) again.This disease is often involved organs such as nervous system, digestive tract, lung, kidney and epididymis, and the state of an illness is the alternation procedure that shows effect repeatedly and alleviate.This disease all has discovery later on all over the world by Turkey dermatologist Behcet first report.Primary disease is high at Japan, Korea, China, the Middle and the Near East (Turkey, Iran) and Eastern Mediterranean area sickness rate far beyond west American-European countries.This disease age of onset mostly is 16～40 years old person between twenty and fifty greatly, and China slightly occupies the majority with the women.
This disease pathogenesis etiology is indeterminate, and infection, heredity, dysimmunity have proof relevant with the primary disease morbidity.Pathological changes is to corrode small artery, venule and blood capillary, can see lymphocyte and monocyte infiltration, angionecrosis in the sick blood vessel that decreases and the surrounding tissue, expand, break, intracavity thrombosis or fibroplasia cause luminal stenosis; pathological changes can be involved the whole body blood vessel; as the minute blood vessel inflammation of skin mucosa, eyes and whole body multisystem, and most cases are also with the joint symptom of different Cheng Du.
Oral cavity and genital ulcer are the first symptoms of BD, the visible oral ulcer of the patient more than 98%, the visible genital ulcer of 80% patient.Ulcer shows as cheek mucosa, lingual margin, lip, soft palate and genitals etc. and locates to see red brief summary, continues with ulcer, and the ulcer diameter is generally 2～3mm.Have with the herpes onset, disappear about about l4 days, the oral ulcer preventing from scar, but genital ulcer can be lost the person that has the cicatrix because outbreak or lasting several weeks repeatedly are more last.In active stage, the annual outbreak of recurrent oral ulceration at least 3 times, ulcer is risen one after another.Secondly and ulcers of female genital organs is mainly seen in large and small labia, is vagina, also can appear at around perineum or the anus, and pain symptom is apparent in view.
The treatment of this disease is mainly NSAID (non-steroidal anti-inflammatory drug), glucocorticoid at present, even uses immunosuppressant, as colchicine or cyclophosphamide.For mucosal ulcer, oral ulcer is generally used Gentian Violet, and pudendal ulcer generally uses 0.1% acetic acid fluorine hydroxyl prednisone ointment or tetracycline ointment, if ulcer more seriously then just need oral Thalidomide (thalidomide).But above drug use only is the infection that occurs together at ulcer, can not solve the problem of ulcer surface pain, and uses hormones mucomembranous nursing thing to cause drawbacks such as skin quick-hardening, pigmentation easily.
So, still lack a kind of mucomembranous nursing thing that can alleviate Behcet's syndrome mucosal ulcer pain, promote the ulcer surface healing at present clinically.
Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, provides a kind of curative effect certainly, and the fewer mucomembranous nursing thing that is used for Behcet's syndrome of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of mucomembranous nursing thing for Behcet's syndrome, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Radix Ranunculi Ternatis, 8 ~ 15 parts of Radix Stephaniae Cepharanthaes, 8 ~ 15 parts of Herba Ardisiae Japonicaes, 6 ~ 10 parts of Herba Ranunculi Scelerati (Radix Anemones rupicolae)s, 6 ~ 10 parts of gumshiraz, 8 ~ 15 parts of Pheretimas, 6 ~ 10 parts in Cera Flava, 8 ~ 15 parts of Herba seu radix metaplexis, 3 ~ 6 parts of Limonitums.
Its optimum weight proportioning is: 8 parts of Radix Ranunculi Ternatis, 10 parts of Radix Stephaniae Cepharanthaes, 10 parts of Herba Ardisiae Japonicaes, 8 parts of Herba Ranunculi Scelerati (Radix Anemones rupicolae)s, 8 parts of gumshiraz, 10 parts of Pheretimas, 8 parts in Cera Flava, 10 parts of Herba seu radix metaplexis, 5 parts of Limonitums.
Prioritization scheme is to add on the basis of the above with 3 parts of Herba euphorbiae lunulataes.
Wherein said: Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor are sweet, hot, temperature.Return liver, lung meridian.But the merit eliminating stagnation, detumescence.
Radix Stephaniae Cepharanthae for Menispermaceae stephania plant headdress flower Radix Stephaniae Japonicae Stephania cepharantha Hayata, is used as medicine with tuber.The nature and flavor hardship, cold.But the merit heat-clearing and toxic substances removing, cooling blood for hemostasis, dissipating blood stasis for subsidence of swelling.
Herba Ardisiae Japonicae for Myrsinacea Ardisa plant Herba Ardisiae Japonicae Ardisia japonica (Hornsted) Blume, is used as medicine with Herb.The nature and flavor suffering, flat.But the merit relieving cough and resolving phlegm, the detoxifcation of dispeling the wind, promoting blood circulation and stopping pain.
Herba Ranunculi Scelerati (Radix Anemones rupicolae) is for Ranunculaceae ranunculus Herba Ranunculi Scelerati (Radix Anemones rupicolae) Ranunculus sceleratus L., with all herbal medicine.Nature and flavor hardship, suffering, flat.Poisonous.Merit can be subsided a swelling, the eliminating stagnation of drawing out pus by applying a plaster to the affected part, preventing the attack (or recurrence) of malaria.
Gumshiraz is rosaceous plant peach Prunus persica (L.) Batsch, the resin that flows out on the trunk.Nature and flavor hardship, flat.Merit can be invigorated blood circulation, and QI invigorating is quenched the thirst.
Pheretima, dry body for the huge earthworm animal Pheretima aspergillum Pheretima aspergillum of section (E. Perrier), popular Pheretimatschiliensis Pheretima vulgaris Chen, William Pheretimatschiliensis Pheretima guillelmi (Michaelsen) or the blind Pheretimatschiliensis Pheretima of comb pectinifera Michaelsen, nature and flavor hardship, flat, but merit heat clearing away, suppressing the hyperactive liver, Zhichuan, collateral dredging.
Cera Flava is the wax of Apidae insecticide apis cerana Apis cerana Fabricius or apis mellifera Linnaeus Apis mellifera Linnaeus secretion.Nature and flavor are sweet, tepor.But the merit astringent therapy is held back skin ulcer, granulation promoting, pain relieving.
Herba seu radix metaplexis is for asclepiadaceae Herba seu radix metaplexis platymiscium Herba seu radix metaplexis Metaplexis japonica (Thunb.) Makino, with tuber, all herbal medicine.Sweet, the little suffering of nature and flavor, temperature.But merit QI invigorating benefit is smart, promoting flow of QI and blood, subduing swelling and detoxicating.
Limonitum is oxide mineral limonite Pyrite; The tuberculosis of Limonite.Nature and flavor are sweet; Cold.The GUIXIN bag; Liver Channel.Merit can be calmed the nerves relieving convulsion; The hemostasis analgesic therapy.
Herba euphorbiae lunulatae is the herb of Euphorbiaceae euphorbia Herba euphorbiae lunulatae Euphorbia lunulata Bunge.The nature and flavor hardship, cold.But the merit inducing diuresis to remove edema, it is antipruritic to draw out pus by applying a plaster to the affected part.
Composition principle: Behcet's syndrome is a kind of general, chronic, vasculitic disease.This disease pathogenesis etiology is indeterminate, may be relevant with factors such as infection, heredity, environment and immunologic dysfunctions.Pathological changes is to corrode small artery, venule and blood capillary, can see lymphocyte and monocyte infiltration, angionecrosis in the sick blood vessel that decreases and the surrounding tissue, expand, break, intracavity thrombosis or fibroplasia cause luminal stenosis; pathological changes can be involved the whole body blood vessel; as the minute blood vessel inflammation of skin mucosa, eyes and whole body multisystem, and most cases are also with the joint symptom of different Cheng Du.Chinese traditional treatment is often started with from heat clearing away, dehumidifying, but the inventor for many years clinical experience think that primary disease belongs to the endogenous cause of ill exopathogenic factor and closes and cause a disease, and exerts a pernicious influence in whole body.
The present invention has following characteristics compared with the prior art:
1, prescription uniqueness: get the detoxifcation of dispeling the wind of Radix Ranunculi Ternati eliminating stagnation, Radix Stephaniae Cepharanthae heat-clearing and toxic substances removing, Herba Ardisiae Japonicae, the three cooperates, start with at pathogenic wind, pyretic toxicity respectively, solve the local vessel wall necrosis and cause mucosal ulcer, process inventor clinical groping for many years draws, this three flavors medicine cooperates incident reason---the minute blood vessel inflammation that can effectively solve ulcer, namely causes a disease and must ask it;
2, giving consideration to both the incidental and fundamental: Radix Ranunculi Ternati, Radix Stephaniae Cepharanthae, the medicine of Herba Ardisiae Japonicae for effecting a permanent cure, and the pain that mucosal ulcer brings, then by Herba Ardisiae Japonicae promoting blood circulation and stopping pain, the pain relieving of Cera Flava expelling pus and promoting granulation, Limonitum hemostasis analgesic therapy, acute stage pain very, then add Herba euphorbiae lunulatae in the prioritization scheme and draw out pus by applying a plaster to the affected part antipruriticly, multiple angles is started with, and reaches the effect of rapid pain relieving, the combination of this kind analgesic drug product is that the inventor tests gained for many years, and mucosal ulcer is had specificity;
3, the mucosa repairing effect is rapid: the in vitro tests of Radix Ranunculi Ternati, Herba Ranunculi Scelerati (Radix Anemones rupicolae), Pheretima three liquid medicine decocts confirms to promote the mucosa repair ability, and this kind mucosa repair ability is not to finish for approach by blood vessel dilating, the local blood of increase, but by increasing the effect that new capillary vessel tube wall cell membrane stability produces, also namely make new vessels no longer be subjected to lymphocyte and monocyte infiltration and produce pathology effects;
4, use this collateral dredging medicine of Pheretima, make medicine local diffusion speed increase, and local nonirritant;
5, gumshiraz, Cera Flava can form protecting film at mucomembranous surface, make the vaginal mucosa ulcer surface be not easy to be polluted and produce secondary infection, thereby add healing;
6, BD belongs to deficiency in origin and excess in superficiality, so the part is selected gumshiraz QI invigorating, Herba seu radix metaplexis QI invigorating benefit essence for use, this two medicines local external use good absorbing effect is better than tonification medicines such as the Radix Astragali, Radix Codonopsis, Radix Adenophorae (Radix Glehniae);
7, pay attention to the local ion balance: the Limonitum composition is moisture iron sesquioxide, and various trace elements such as manganese, phosphorus, calcium, vanadium, and inventor's result of study shows, in prescription, add this medicine, be conducive to promote the mucosa reparation, may be because BD to fall ill, local ion imbalance is relevant;
8, avoid using clearing away damp-heat, removing dampness medicine, because the clearing away heat and eliminating dampness medicine has dry property more, short run effect is good, but long-term prognosis is bad, the relapse rate height;
9, avoid using the medicine with blood vessel dilating effect, its reason is that blood vessel dilating also can cause blood capillary tube wall permeability to increase, itself just has the BD pathologic basis angionecrosis, expands, breaks, then intracavity thrombosis or fibroplasia cause luminal stenosis, blood vessel dilating can be temporary transient the alleviation luminal stenosis, but increased the weight of the blood vessel wall burden on the contrary;
10, mucomembranous nursing raw material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: Radix Ranunculi Ternati 6g, Radix Stephaniae Cepharanthae 8g, Herba Ardisiae Japonicae 8g, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 6g, gumshiraz 6g, Pheretima 8g, Cera Flava 6g, Herba seu radix metaplexis 8g, Limonitum 3g.
Embodiment 2, the crude drug weight proportion: Radix Ranunculi Ternati 10g, Radix Stephaniae Cepharanthae 15g, Herba Ardisiae Japonicae 15g, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 10g, gumshiraz 10g, Pheretima 15g, Cera Flava 10g, Herba seu radix metaplexis 15g, Limonitum 6g.
Embodiment 3, the crude drug weight proportion: Radix Ranunculi Ternati 8g, Radix Stephaniae Cepharanthae 10g, Herba Ardisiae Japonicae 10g, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 8g, gumshiraz 8g, Pheretima 10g, Cera Flava 8g, Herba seu radix metaplexis 10g, Limonitum 5g.
When embodiment 1 ~ 3 uses, Chinese medicine Radix Ranunculi Ternati of the present invention, Radix Stephaniae Cepharanthae, Herba Ardisiae Japonicae, Herba Ranunculi Scelerati (Radix Anemones rupicolae), Pheretima, Limonitum and Herba seu radix metaplexis are decocted with water twice, add gumshiraz, Cera Flava under the merging filtrate, heated condition, after concentrating, dividing sooner or later, the vaginal mucosa part is coated with usefulness.
Embodiment 4, the crude drug weight proportion: Radix Ranunculi Ternati 6g, Radix Stephaniae Cepharanthae 8g, Herba Ardisiae Japonicae 8g, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 6g, gumshiraz 6g, Pheretima 8g, Cera Flava 6g, Herba seu radix metaplexis 8g, Limonitum 3g, Herba euphorbiae lunulatae 2g.
Embodiment 5, the crude drug weight proportion: Radix Ranunculi Ternati 10g, Radix Stephaniae Cepharanthae 15g, Herba Ardisiae Japonicae 15g, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 10g, gumshiraz 10g, Pheretima 15g, Cera Flava 10g, Herba seu radix metaplexis 15g, Limonitum 6g, Herba euphorbiae lunulatae 2g.
Embodiment 6, the crude drug weight proportion: Radix Ranunculi Ternati 8g, Radix Stephaniae Cepharanthae 10g, Herba Ardisiae Japonicae 10g, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 8g, gumshiraz 8g, Pheretima 10g, Cera Flava 8g, Herba seu radix metaplexis 10g, Limonitum 5g, Herba euphorbiae lunulatae 2g.
When embodiment 4 ~ 6 uses, Chinese medicine Radix Ranunculi Ternati of the present invention, Radix Stephaniae Cepharanthae, Herba Ardisiae Japonicae, Herba Ranunculi Scelerati (Radix Anemones rupicolae), Pheretima, Limonitum, Herba seu radix metaplexis and Herba euphorbiae lunulatae are decocted with water twice, add gumshiraz, Cera Flava under the merging filtrate, heated condition, after concentrating, dividing sooner or later, the vaginal mucosa part is coated with usefulness.
Above embodiment can make ointment, emulsifiable paste in conjunction with existing practice of pharmacy except above-mentioned preparation method, the local use.
Effective combination of above-mentioned mucomembranous nursing thing is coordinated mutually, can effectively reach the purpose of alleviating Behcet's syndrome mucosal ulcer pain, promote ulcer healing, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies the mucomembranous nursing thing and uses and be the crude drug weight proportion among embodiment 3 and the embodiment 6.
1 object and method.
1.1 object.
1.1.1 the standard of including in: be that in January, 2009 ~ 2012 a year JIUYUE is made a definite diagnosis Behcet's syndrome with recurrent genital ulcer female patient, described recurrent refers to and shows effect at least repeatedly in 1 year 3 times.The equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.
1.1.2 Behcet's syndrome diagnosis basis: repeatability oral ulcer (comprising light-duty aphtha, heavy big ulcer or herpes template ulcer), and have in following 4 any 2 in succession or do not occur the person simultaneously: 1. recurrent genital ulcer or cicatrix: it is reliable must observing or be provided and be confirmed to be by the patient through the doctor; 2. eye infringement: comprise anterior uveitis and posterior uveitis, find vitreous opacity or retinal vasculitis during slit lamp examination; 3. skin lesion: comprise erythema nodosum, pseudofolliculitis and purulence pimple, do not use glucocorticoid, non-adolescence person and the acne sample tuberosity that occurs; 4. acupuncture reacting positive: test is by the positive reaction of being judged by the doctor after 24～48 hours.
1.1.3 case situation: selected 60 examples, age span 16 ~ 41 years old, 28.13 ± 9.62 years old mean age.
1.2 method.
1.2.1 grouping: selected 60 examples, be divided into matched group 30 examples, 30 examples are organized in treatment.Two groups of case age differences not statistically significants, P〉0.05, have comparability.
1.2.2 research method: matched group local topical 0.1% acetic acid fluorine hydroxyl prednisone ointment, treatment group adopt the medicine external in the embodiment of the invention 3, gained medicine external among the heavier employing embodiment 6 of acute stage pain.All case medications are 2 times/d, share 10d.
1.2.3 safety evaluatio: all carry out monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after the medication.
1.2.4 statistical analysis: carry out statistical analysis with SPSS 13.0, P＜0.05 expression has the significance meaning.
2 results.
2.1 two groups of curative effect comparisions: pain obviously alleviates or alleviates.All apparently higher than the cure rate of matched group (10. 0%), obvious effective rate (10. 0%), difference has statistical significance (p＜0.05) to the cure rate (33. 3%), obvious effective rate (60. 0%) for the treatment for the treatment of group after 10 days.
2.2 two groups of effective case pain relieving times: effectively in the case, it is 4.11 ± 1.08d that average pain relieving time is organized in treatment, and matched group is 7.32 ± 3.17d, and the two compares, and the treatment group obviously is better than matched group (p＜0.01).
2.3 untoward reaction: two groups the obvious adverse reaction record all do not occur.
2.4 relapse rate: followed the trail of case 1 year, the internal therapy group had 30.00%(9/30 in 1 year) recurrence, matched group has 63.33%(19/30) recurrence, and the two compares, and treatment group relapse rate is starkly lower than matched group (p＜0.01).
3. conclusion.
The prompting of this result of study, the present invention are used for Behcet's syndrome and have good effect and the higher characteristics of safety, are worth clinical practice, popularization.
Claims (2)
1. mucomembranous nursing thing that is used for Behcet's syndrome, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Radix Ranunculi Ternatis, 8 ~ 15 parts of Radix Stephaniae Cepharanthaes, 8 ~ 15 parts of Herba Ardisiae Japonicaes, 6 ~ 10 parts of Herba Ranunculi Scelerati (Radix Anemones rupicolae)s, 6 ~ 10 parts of gumshiraz, 8 ~ 15 parts of Pheretimas, 6 ~ 10 parts in Cera Flava, 8 ~ 15 parts of Herba seu radix metaplexis, 3 ~ 6 parts of Limonitums.
2. a kind of mucomembranous nursing thing for Behcet's syndrome according to claim 1 is characterized in that its composition of raw materials and weight proportion are: 8 parts of Radix Ranunculi Ternatis, 10 parts of Radix Stephaniae Cepharanthaes, 10 parts of Herba Ardisiae Japonicaes, 8 parts of Herba Ranunculi Scelerati (Radix Anemones rupicolae)s, 8 parts of gumshiraz, 10 parts of Pheretimas, 8 parts in Cera Flava, 10 parts of Herba seu radix metaplexis, 5 parts of Limonitums.
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