CN102920837A - Traditional Chinese medicine for treating arrhythmia and preparation process and application thereof - Google Patents
Traditional Chinese medicine for treating arrhythmia and preparation process and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating arrhythmia and a preparation process and an application thereof. The preparation process takes Radix Astragali, Codonopsis Pilosula, Scrophularia Ningpoensis, Salvia Miltiorrhiza, Radix Adenophorae, Sophora Flavescens Ait and Radix Glycyrrhizae Preparate as raw materials for preparing different dosage forms such as tablets, pills, capsules, solution, oral liquid, buccal tablets, granules, dissolved medicines, pulvis, suspension or powder. The Shenqi Yangxin prescription has the efficacies of nourishing yin and tonifying blood, and benefiting vital energy and supporting heart, and is used in the treatment of arrhythmia, ventricular premature beat and the like.
Description
Technical field
The present invention relates to a kind of effect with nourishing YIN and benefiting blood, Qi-benefiting and heart-nourishing, be used for the treatment of arrhythmia, the Chinese medicine of the diseases such as ventricular premature contraction and preparation technology thereof and application.
Background technology
At present, stress change systema cariovasculare functional and definitely be studied proof.There are some researches show that overtired stress state can bring out vascular endothelium dysfunction, and body is under the stress state, the ventricular muscles electrical instability obviously increases, and ventricle VFT significantly reduces, and susceptibility significantly increases to ventricular arrhythmia.Simultaneously, along with the raising of modern life level, the quickening of work rhythm and the increase of competitive pressure, the sickness rate of cardiovascular and cerebrovascular disease increases year by year, has become the harm health of people, affects one of principal disease of life quality.
The ginseng and astragalus psyche-nourishing prescription is as the clinical common medicine of cardiovascular disease, obtain clinician and patient's consistent approval, a kind for the treatment of and prophylactic agent of satisfaction are provided for cardiovascular patient, having obtained preferably Social benefit and economic benefit, is determined curative effect in the similar drugs, safe and reliable, the outstanding preparation variety that is worthy of popularization.
Ginseng and astragalus psyche-nourishing prescription is take the Radix Astragali and the QI invigorating of QI invigorating, yang invigorating, the Radix Codonopsis that promotes the production of body fluid, nourish blood as principal agent, in conjunction with have the promoting the circulation of blood arteries and veins, fall heart-fire, the medicine such as Radix Salviae Miltiorrhizae of YIN nourishing, Radix Adenophorae (Radix Glehniae), have the enhancing coronary flow, improve blood supply of cardiac muscle, regulate myocardial metabolism, improve microcirculatory function.Extract purification techniques by modern preparation, effective ingredient in the enrichment medical material, employing science preparation technology makes steady quality, controlled, the carrying convenience of safety, taking convenience, absorption is rapid, rapid-action and bioavailability is high new medicine preparation, satisfies clinical demand.
Summary of the invention
Goal of the invention
A kind of treat ARR Chinese medicine and preparation technology and application have been the present invention relates to, its purpose is to remedy the deficiencies in the prior art, provide a kind of bioavailability high to extensive patients and medical personnel, fast release, quick produce effects, toxic and side effects is little, and the ginseng and astragalus psyche-nourishing drop pill of taking convenience.
Technical scheme
The present invention is achieved through the following technical solutions:
A kind ofly treat ARR Chinese medicine, it is characterized in that: made by following raw material according to the weight portion meter: Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part.
Aforesaid a kind of preparation technology who treats ARR Chinese medicine, it is characterized in that: step is as follows:
(1) gets according to the above ratio each raw material: Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part;
(2) adding 6-12 times of water gaging decocts 1-4 time, each 0.5-4 hour, collecting decoction filtered, filtrate is concentrated into the clear paste of relative density 1.1～1.3, add ethanol and carry out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40-80%, leaves standstill to place 48 hours, draw supernatant, concentrate, namely get the extract that contains above-mentioned seven flavor Chinese medicines, for subsequent use.
Be prepared into tablet, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid or powder.
In step (2), be concentrated into the thick paste of relative density 1.1～1.4, obtain containing the extract thick paste of above-mentioned seven flavor Chinese medicines; When the preparation dropping pill formulation, add the pharmaceutically suitable carrier as substrate in the extract thick paste, mixing and get final product, the ratio of extract and substrate is counted 1:0.5～1:10 according to weight portion, and described substrate is that in PEG400, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000, PEG 20000, the glycerin gelatine one or more mix; When the preparation granule, in the extract thick paste, add adjuvant, mixing and get final product, the ratio of extract and adjuvant is counted 1:0.5～1:10 according to weight portion, and described adjuvant is that in dextrin, starch, sucrose, lactose, cellulose family, sweeting agent, the lubricant one or more mix.
Preparation is during dropping pill formulation, and the condensing agent of use is liquid paraffin, methyl-silicone oil, the mixing of any one in the vegetable oil or more than one.
When the preparation tablet, in the extract by above-mentioned seven flavor Chinese medicines of containing of obtaining in the step (2) after drying, add adjuvant, the ratio of extract and adjuvant is counted 1:0.5～1:10 according to weight portion, and described adjuvant is that in cellulose family, dextrin, lactose, starch, sweeting agent, the lubricant one or more mix.
When the preparation honeyed pill, with each raw material pulverizing for subsequent use in the step (1), cross the 40-80 mesh sieve, add Mel, mixing is made honeyed pill and is got final product; The mass ratio of described mixing medicinal powder and Mel is 1: 0.5～1: 5.
The purposes of the ARR Chinese medicine of described treatment is as treatment arrhythmia, the application of ventricular premature contraction medicine.
Advantage and effect
The present invention proposes a kind of treat ARR Chinese medicine and preparation technology and application, have following advantage:
The dosage form that the present invention selects can be prepared and be fit to the sugar-free dosage form that diabetics is taken, and enlarges the use crowd of said preparation.We choose the nourishing YIN and benefiting blood medicine and the invigorating the spleen and benefiting QI medicine is compatible, and yin nourishing and heat clearing away develop simultaneously, and make QI and blood sufficient, YIN and YANG balancing, and multiple feeling pulse is originally.We are effective prescriptions for the treatment of arrhythmia, ventricular premature contraction.The prescription science rationally, meets theory of Chinese medical science.The ginseng and astragalus psyche-nourishing prescription is that the applicant is according to effective prescription of for many years clinical experience independent research.Through for many years clinical verification, curative effect is reliable, definite.Had vast application crowd.It is at present, clinical that to be used for the treatment of ARR Chinese medicine kind fewer.We are clinical to be used for the treatment of because deficiency of vital energy insufficiency of blood, cardiopalmus due to the insufficiency of heart-YIN, blood failing to tonify the heart, and effect is remarkable, has unique advantage in existing market is treated the medicine of this type of disease.
Different dosage forms has advantages of different, and it is high that dropping pill formulation has bioavailability, fast release, and quick produce effects, toxic and side effects is little, and the advantage such as taking convenience; Pure Chinese medicine pill preparation has taking convenience, has no side effect, dosage is moderate, the obvious advantage of curative effect; Granular preparation has good stability, curative effect is high; Tablet has the stay-in-grade advantage of good absorbing, taking convenience and long term storage.
Description of drawings
Fig. 1 is that different dosage form of the present invention is on the ARR schematic diagram that affects of mice.
The specific embodiment
The present invention is described further below in conjunction with specific embodiment:
The invention provides a kind of ARR Chinese medicine for the treatment of, made by following raw material according to the weight portion meter: Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part.
The ARR Chinese medicine of above-mentioned treatment can adopt tablet, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid or powder.
A kind of preparation technology who treats as mentioned above ARR Chinese medicine, its step of preparation process is as follows:
(1) gets according to the above ratio each raw material: Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part;
(2) adding 6-12 times of water gaging decocts 1-4 time, each 0.5-4 hour, collecting decoction filtered, filtrate is concentrated into the clear paste of relative density 1.1～1.3, add ethanol and carry out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40-80%, leaves standstill to place 48 hours, draw supernatant, concentrate, namely get the extract that contains above-mentioned seven flavor Chinese medicines, for subsequent use.
Take the above-mentioned Radix Astragali, Radix Codonopsis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, Radix Adenophorae (Radix Glehniae), Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata as raw material, be prepared into different dosage forms, for example: the said extracted thing can be prepared into dropping pill formulation or the said extracted thing is prepared into granule or tablet with adjuvant with the pharmaceutically suitable carrier as substrate, also above-mentioned raw materials directly can be mixed with into honeyed pill with Mel.
Ginseng and astragalus psyche-nourishing dropping pill formulation bioavailability is high, fast release, and quick produce effects, toxic and side effects is little, and taking convenience; Pure Chinese medicine pill preparation taking convenience, have no side effect, dosage is moderate, curative effect is obvious; The ginseng and astragalus psyche-nourishing granule stability is good, curative effect is high; Ginseng and astragalus psyche-nourishing tablet good absorbing, taking convenience and long term storage steady quality.
1. method for preparing drop pills
(1) extraction of raw material and preparation: get Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part adds 6-12 times of water gaging and decocts 1-4 time, each 0.5-4 hour, collecting decoction filters, and filtrate is concentrated into the clear paste of relative density 1.1～1.3, add ethanol and carry out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40-80%, leaves standstill to place 48 hours, draws supernatant, concentrate, be concentrated into the thick paste of relative density 1.1～1.4, namely get the extract thick paste that contains above-mentioned seven flavor Chinese medicines, for subsequent use;
(2) substrate: PEG400, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000, PEG 20000, glycerin gelatine, one or more in above-mentioned pharmaceutically suitable carrier mix;
(3) proportioning: take g or kg as unit, by weight, drug extract thick paste: substrate=1: 0.5～1: 10;
(4) temperature for the treatment of condensing agent in pill dripping machine water dropper and the condensation column is stablized respectively when reaching desired state of temperature, to contain the fused solution of extract drugs thick paste and substrate and/or emulsion and/or suspension places in the water dropper tank of pill dripping machine, splash in the condensing agent, shrink molding.Condensing agent is selected any one in liquid paraffin, methyl-silicone oil or the vegetable oil, or more than one mixture (for example optional methyl-silicone oil); The drop pill that will be shunk molding by the pill dripping machine outlet takes out, and removes the surface condensation agent, is drying to obtain.
2. honeyed pill preparation method
Take the Radix Astragali, Radix Codonopsis, Radix Scrophulariae, Radix Salviae Miltiorrhizae, Radix Adenophorae (Radix Glehniae), Radix Sophorae Flavescentis, Radix Glycyrrhizae Preparata as raw material, with each raw material pulverizing for subsequent use in the step (1), cross 40～80 mesh sieves, add Mel, mixing is made honeyed pill and is got final product; The mass ratio of described mixing medicinal powder and Mel is 1: 0.5～1: 5.
3. process for producing granula
(1) according to the weight portion meter, gets Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part, add 6-12 times of water gaging and decoct 1-4 time, each 0.5-4 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.1～1.3, adds ethanol and carries out precipitate with ethanol, and alcohol is sink to ethanol content and reaches 40-80%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.1～1.4, namely get the extract thick paste that contains above-mentioned seven flavor Chinese medicines, for subsequent use;
(2) described adjuvant is dextrin, starch, sucrose, lactose, cellulose family, sweeting agent, lubricant; In the above-mentioned pharmaceutically acceptable auxiliaries one or more mix, and according to the weight portion meter, describedly contain the above-mentioned 7 flavor extract thick pastes of Chinese medicines and the ratio of adjuvant is 1:0.5～1:10.
4. method for preparing tablet thereof
(1) according to the weight portion meter, gets Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part, add 6-12 times of water gaging and decoct 1-4 time, each 0.5-4 hour, collecting decoction filtered, filtrate is concentrated into the clear paste of relative density 1.1～1.3, adds ethanol and carries out precipitate with ethanol, and alcohol is sink to ethanol content and reaches 40-80%, leave standstill and placed 48 hours, draw supernatant, concentrate, drying namely gets the extract that contains above-mentioned seven flavor Chinese medicines, and is for subsequent use;
(2) described adjuvant is cellulose family, dextrin, lactose, starch, sweeting agent, lubricant; In the above-mentioned pharmaceutically acceptable auxiliaries one or more mix, and according to the weight portion meter, describedly contain the above-mentioned 7 flavor extracts of Chinese medicines and the ratio of adjuvant is 1:0.5～1:10.
The purposes of the ARR Chinese medicine of this treatment of the present invention, as the treatment arrhythmia, the application of ventricular premature contraction medicine has the effect of nourishing YIN and benefiting blood, Qi-benefiting and heart-nourishing.
The present invention is described further below in conjunction with specific embodiment.
Embodiment 1:
Write out a prescription composed as follows: (g)
Preparation technology: get 2 parts of the Radixs Astragali, 1 part of Radix Codonopsis, 1 part of Radix Scrophulariae, 1 part of Radix Salviae Miltiorrhizae, 1 part of Radix Adenophorae (Radix Glehniae), 0.5 part of Radix Sophorae Flavescentis, 0.5 part of Radix Glycyrrhizae Preparata, take by weighing medical material by above-mentioned prescription, add 10 times of water gagings and decoct each 2 hours 2 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.18, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 60%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.32, add the substrate Polyethylene Glycol (PEG) 4000 of recipe quantity, mixing carries out dripping.Or add other adjuvant and prepare other dosage form.
Embodiment 2:
Write out a prescription composed as follows: (g)
Preparation technology: get 10 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 5 parts of Radix Scrophulariaes, 5 parts of Radix Salviae Miltiorrhizaes, Radix Adenophorae (Radix Glehniae) 5,3 parts of Radix Sophorae Flavescentiss, 3 parts of Radix Glycyrrhizae Preparatas, take by weighing medical material by above-mentioned prescription, add 10 times of water gagings and decoct each 2 hours 2 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.18, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 50%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.31, add the substrate Polyethylene Glycol (PEG) 6000 of recipe quantity, mixing carries out dripping.
Embodiment 3:
Write out a prescription composed as follows: (g)
Preparation technology: get 6 parts of the Radixs Astragali, 3 parts of Radix Codonopsis, 2 parts of Radix Scrophulariaes, 3 parts of Radix Salviae Miltiorrhizaes, 3 parts of Radix Adenophorae (Radix Glehniae), 1.5 parts of Radix Sophorae Flavescentiss, 1.5 parts of Radix Glycyrrhizae Preparatas, take by weighing medical material by above-mentioned prescription, add 12 times of water gagings and decoct each 4 hours 1 time, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.1, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.1, add the substrate Polyethylene Glycol (PEG) 2000 of recipe quantity, mixing carries out dripping.
Embodiment 4:
Write out a prescription composed as follows: (g)
Preparation technology: get 8 parts of the Radixs Astragali, 4 parts of Radix Codonopsis, 4 parts of Radix Scrophulariaes, 3 parts of Radix Salviae Miltiorrhizaes, 3 parts of Radix Adenophorae (Radix Glehniae), 2 parts of Radix Sophorae Flavescentiss, 2 parts of Radix Glycyrrhizae Preparatas, take by weighing medical material by above-mentioned prescription, add 6 times of water gagings and decoct each 0.5 hour 4 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.3, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 80%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.4, add substrate Polyethylene Glycol (PEG) 400 and the matter Polyethylene Glycol (PEG) 8000 of recipe quantity, mixing carries out dripping.
Embodiment 5:
Write out a prescription composed as follows: (g)
Preparation technology: get 4 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 4 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 1 part of Radix Sophorae Flavescentis, 1 part of Radix Glycyrrhizae Preparata, take by weighing medical material by above-mentioned prescription, add 8 times of water gagings and decoct each 3 hours 3 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.2, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 70%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.25, add the substrate Polyethylene Glycol (PEG) 8000 of recipe quantity, mixing carries out dripping.
Embodiment 6:
Write out a prescription composed as follows: (g)
Preparation technology: get 2 parts of the Radixs Astragali, 1 part of Radix Codonopsis, 1 part of Radix Scrophulariae, 1 part of Radix Salviae Miltiorrhizae, 1 part of Radix Adenophorae (Radix Glehniae), 0.5 part of Radix Sophorae Flavescentis, 0.5 part of Radix Glycyrrhizae Preparata, take by weighing medical material by above-mentioned prescription, add 10 times of water gagings and decoct each 2 hours 3 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.19, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 60%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.33, add substrate PEG4000 and the PEG6000 of recipe quantity, mixing carries out dripping.
Embodiment 7:
Substrate is any in Polyethylene Glycol (PEG) 10000, Polyethylene Glycol (PEG) 20000 or the glycerin gelatine, and prescription composition and preparation technology are with embodiment 1.
Embodiment 8:
Write out a prescription composed as follows: (g)
Preparation technology is with embodiment 6.
Embodiment 9:
Write out a prescription composed as follows: (g)
Preparation technology is with embodiment 6.
Embodiment 10:
Write out a prescription composed as follows: (g)
Substrate is that PEG400, PEG 8000 and PEG20000 mix, and preparation technology is with embodiment 6.
Embodiment 11:
Write out a prescription composed as follows: (g)
Substrate is that PEG400, Macrogol 4000, PEG20000, PEG 20000, glycerin gelatine mix, and preparation technology is with embodiment 6.
Embodiment 12:
Write out a prescription composed as follows: (g)
Preparation technology: get 5 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 1 part of Radix Sophorae Flavescentis, 1.5 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, with pulverizing medicinal materials, cross 80 mesh sieves, add Mel, and mixing is made honeyed pill.
Embodiment 13:
Write out a prescription composed as follows: (g)
Preparation technology: get 7 parts of the Radixs Astragali, 3 parts of Radix Codonopsis, 3 parts of Radix Scrophulariaes, 4 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Adenophorae (Radix Glehniae), 2.5 parts of Radix Sophorae Flavescentiss, Radix Glycyrrhizae Preparata 2.5 takes by weighing medical material by above-mentioned prescription, with pulverizing medicinal materials, crosses 60 mesh sieves, adds Mel, and mixing is made honeyed pill.
Embodiment 14:
Write out a prescription composed as follows: (g)
Preparation technology: get 2 parts of the Radixs Astragali, 1 part of Radix Codonopsis, 1 part of Radix Scrophulariae, 1 part of Radix Salviae Miltiorrhizae, 1 part of Radix Adenophorae (Radix Glehniae), 0.5 part of Radix Sophorae Flavescentis, 0.5 part of Radix Glycyrrhizae Preparata takes by weighing medical material by above-mentioned prescription, with pulverizing medicinal materials, crosses 80 mesh sieves, adds Mel, and mixing is made honeyed pill.
Embodiment 15:
Write out a prescription composed as follows: (g)
Preparation technology: get 10 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 5 parts of Radix Scrophulariaes, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Adenophorae (Radix Glehniae), 3 parts of Radix Sophorae Flavescentiss, 3 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, with pulverizing medicinal materials, cross 20 mesh sieves, add Mel, and mixing is made honeyed pill.
Embodiment 16:
Write out a prescription composed as follows: (g)
Preparation technology: get 4 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 3 parts of Radix Salviae Miltiorrhizaes, 4 parts of Radix Adenophorae (Radix Glehniae), 3 parts of Radix Sophorae Flavescentiss, 2 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, with pulverizing medicinal materials, cross 50 mesh sieves, add Mel, and mixing is made honeyed pill.
Embodiment 17:
Write out a prescription composed as follows: (g)
Preparation technology: get 2 parts of the Radixs Astragali, 1 part of Radix Codonopsis, 1 part of Radix Scrophulariae, 1 part of Radix Salviae Miltiorrhizae, 1 part of Radix Adenophorae (Radix Glehniae), 0.5 part of Radix Sophorae Flavescentis, 0.5 part of Radix Glycyrrhizae Preparata takes by weighing medical material by above-mentioned prescription, add 12 times of water gagings and decoct 3 times, each 1.5 hours, collecting decoction filtered, filtrate is concentrated into the clear paste of relative density 1.17, adds ethanol and carries out precipitate with ethanol, and alcohol is sink to ethanol content and reaches 65%, leaves standstill to place 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.26, the adjuvant dextrin that adds recipe quantity, mixing, granulation.The adjuvant dextrin also can use a kind of in other adjuvants such as starch, sucrose, cellulose family or the lactose.
Embodiment 18:
Write out a prescription composed as follows: (g)
Preparation technology: get 10 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 5 parts of Radix Scrophulariaes, 5 parts of Radix Salviae Miltiorrhizaes, Radix Adenophorae (Radix Glehniae) 5,3 parts of Radix Sophorae Flavescentiss, 3 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, add 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction filtered, filtrate is concentrated into the clear paste of relative density 1.19, adds ethanol and carries out precipitate with ethanol, and alcohol is sink to ethanol content and reaches 50%, leaves standstill to place 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.28, the adjuvant dextrin and the cane sugar powder that add recipe quantity, mixing, granulation.
Embodiment 19:
Write out a prescription composed as follows: (g)
Preparation technology: get 5 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 1 part of Radix Sophorae Flavescentis, 1.5 parts of Radix Glycyrrhizae Preparatas, take by weighing medical material by above-mentioned prescription, add 6 times of water gagings and decoct each 0.5 hour 4 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.1, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.1, the supplementary product starch and the saccharin sodium that add recipe quantity, mixing, granulation.
Embodiment 20:
Write out a prescription composed as follows: (g)
Preparation technology: get 4 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 4 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 1 part of Radix Sophorae Flavescentis, 1 part of Radix Glycyrrhizae Preparata, take by weighing medical material by above-mentioned prescription, add 8 times of water gagings and decoct each 4 hours 1 time, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.3, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 80%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.4, the microcrystalline cellulose excipients, lactose and the stevioside that add recipe quantity, mixing, granulation.
Embodiment 21:
Write out a prescription composed as follows: (g)
Preparation technology: get 8 parts of the Radixs Astragali, 4 parts of Radix Codonopsis, 4 parts of Radix Scrophulariaes, 3 parts of Radix Salviae Miltiorrhizaes, 3 parts of Radix Adenophorae (Radix Glehniae), 2 parts of Radix Sophorae Flavescentiss, 2 parts of Radix Glycyrrhizae Preparatas, take by weighing medical material by above-mentioned prescription, add 12 times of water gagings and decoct each 1.5 hours 3 times, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.17, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 65%, leave standstill and placed 48 hours, draw supernatant, concentrate, be concentrated into the thick paste of relative density 1.26, the supplementary product starch, sucrose, lactose and the aspartame that add recipe quantity, mixing, granulation.
Embodiment 22:
Write out a prescription composed as follows: (g)
Preparation technology: get 10 parts of the Radixs Astragali, 5 parts of Radix Codonopsis, 5 parts of Radix Scrophulariaes, 5 parts of Radix Salviae Miltiorrhizaes, Radix Adenophorae (Radix Glehniae) 5,3 parts of Radix Sophorae Flavescentiss, 3 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, add 10 times of water gagings and decoct 2 times, each 2 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.18, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 60%, leaves standstill to place 48 hours, draws supernatant, concentrate, drying obtains the ginseng and astragalus psyche-nourishing extract.Extract adds the adjuvants such as lactose, starch, carboxymethyl starch sodium (disintegrating agent), and adding an amount of 0.5% sodium carboxymethyl cellulose is binding agent, and soft material processed is crossed 20 mesh sieves and granulated, drying, and 20 mesh sieve granulate add magnesium stearate (lubricant) tabletting, and get final product.
Embodiment 23:
Write out a prescription composed as follows: (g)
Preparation technology: get 2 parts of the Radixs Astragali, 1 part of Radix Codonopsis, 1 part of Radix Scrophulariae, 1 part of Radix Salviae Miltiorrhizae, 1 part of Radix Adenophorae (Radix Glehniae), 0.5 part of Radix Sophorae Flavescentis, 0.5 part of Radix Glycyrrhizae Preparata takes by weighing medical material by above-mentioned prescription, add 10 times of water gagings and decoct 3 times, each 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.19, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 50%, leaves standstill to place 48 hours, draws supernatant, concentrate, drying obtains the ginseng and astragalus psyche-nourishing extract.Extract adds the adjuvants such as microcrystalline Cellulose, starch, adds the disintegrating agent polyvinylpolypyrrolidone, and adding an amount of 5% starch slurry is binding agent, and soft material processed is crossed 20 mesh sieves and granulated, drying, and 20 mesh sieve granulate add the magnesium stearate tabletting, and get final product.
Embodiment 24:
Write out a prescription composed as follows: (g)
Preparation technology: get 5 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 3 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Adenophorae (Radix Glehniae), 2.5 parts of Radix Sophorae Flavescentiss, 1.5 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, add 6 times of water gagings and decoct 1 time, each 4 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.1, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40%, leaves standstill to place 48 hours, draws supernatant, concentrate, drying obtains the ginseng and astragalus psyche-nourishing extract.Extract adds the adjuvants such as dextrin, starch, and adding an amount of 5% starch slurry is binding agent, and soft material processed is crossed 20 mesh sieves and granulated, drying, and 20 mesh sieve granulate add the magnesium stearate tabletting, and get final product.
Embodiment 25:
Write out a prescription composed as follows: (g)
Preparation technology: get 8 parts of the Radixs Astragali, 3 parts of Radix Codonopsis, 2 parts of Radix Scrophulariaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 2.5 parts of Radix Sophorae Flavescentiss, 2.5 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, add 12 times of water gagings and decoct 4 times, each 0.5 hour, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.3, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 80%, leaves standstill to place 48 hours, draws supernatant, concentrate, drying obtains the ginseng and astragalus psyche-nourishing extract.Extract adds the adjuvants such as microcrystalline Cellulose, hydroxypropyl starch, lactose, and adding an amount of 5% starch slurry is binding agent, and soft material processed is crossed 20 mesh sieves and granulated, drying, and 20 mesh sieve granulate add the magnesium stearate tabletting, and get final product.
Embodiment 26:
Write out a prescription composed as follows: (g)
Preparation technology: get 8 parts of the Radixs Astragali, 3 parts of Radix Codonopsis, 2 parts of Radix Scrophulariaes, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 2.5 parts of Radix Sophorae Flavescentiss, 2.5 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, add 8 times of water gagings and decoct 2 times, each 3 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.2, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 70%, leaves standstill to place 48 hours, draws supernatant, concentrate, drying obtains the ginseng and astragalus psyche-nourishing extract.Extract adds the adjuvants such as microcrystalline Cellulose, lactose, dextrin, starch, and adding an amount of polyvinylpolypyrrolidone is disintegrating agent, and soft material processed is crossed 20 mesh sieves and granulated, drying, and 20 mesh sieve granulate add the magnesium stearate tabletting, and get final product.
Embodiment 27:
The side is composed as follows: (g)
Preparation technology: get 5 parts of the Radixs Astragali, 2 parts of Radix Codonopsis, 1 part of Radix Scrophulariae, 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Adenophorae (Radix Glehniae), 1 part of Radix Sophorae Flavescentis, 1.5 parts of Radix Glycyrrhizae Preparatas take by weighing medical material by above-mentioned prescription, add 5 times of water gagings and decoct 3 times, each 2.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste of relative density 1.19, adds ethanol and carries out precipitate with ethanol, alcohol is sink to ethanol content and reaches 50%, leaves standstill to place 48 hours, draws supernatant, concentrate, drying obtains the ginseng and astragalus psyche-nourishing extract.Extract adds the adjuvants such as starch, low-substituted hydroxypropyl cellulose, and adding an amount of 5% starch slurry is binding agent, and soft material processed is crossed 20 mesh sieves and granulated, drying, and 20 mesh sieve granulate add the magnesium stearate tabletting, and get final product.
Use
(1) the present invention causes the ARR impact of mice to chloroform
Get some of mices, according to experiment situation random packet, ginseng and astragalus psyche-nourishing preparation with above-mentioned four kinds of different dosage forms carries out administration, every day 1 time, each 0.1ml/10g, then successive administration 9 days puts into mice the inverted 600ml beaker of cotton balls (whenever change later on a mice and add the 1ml chloroform) that contains the 3-4ml chloroform one by one, take out immediately to respiratory arrest and to cut the thoracic cavity open, macroscopy heart beating number of times.
Wherein: group 1 is blank group, and group 2 is the drop pill group, and group 3 is the honeyed pill group, and group 4 is the granule group, and group 5 is the tablet group.
The results are shown in Figure 1: Fig. 1 is that different dosage form of the present invention is on the ARR impact of mice.
The result shows: the present invention treats the not normal generation of four kinds of obvious decreasing heart rates of different dosage form of ARR Chinese medicine (ginseng and astragalus psyche-nourishing prescription).
(2) the present invention brings out ARR impact to barium chloride
Get 50 of rats, male and female half and half are divided into 5 groups at random, 10 every group: normal saline group (equal-volume gavage), drop pill group, and the honeyed pill group, the granule group, the tablet group, the gavage volume is 10mL/kg, and gavage is 9 days continuously, once a day.After the last gavage, the chloral hydrate of lumbar injection 10% (300mg/kg), dorsal position is fixed on the constant operation table after the anesthesia, records normal II and leads ECG.Behind the 30min, from quick disposable injection 0.2% barium chloride of sublingual vein (3mg/kg), annotated in the 4s.From inject complete at once, ARR time of occurrence, persistent period in the record 30min.The results are shown in following table 1.
Ginseng and astragalus psyche-nourishing prescription different dosage form to barium chloride cause the rat ventricular model effect (
,
n=10)
Annotate: compare with normal saline,
* p＜0.01
The result shows: the present invention treats the not normal generation of four kinds of obvious decreasing heart rates of different dosage form of ARR Chinese medicine (ginseng and astragalus psyche-nourishing prescription).
Claims (8)
1. the ARR Chinese medicine for the treatment of is characterized in that: made by following raw material according to the weight portion meter: Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part.
2. a kind of preparation technology who treats ARR Chinese medicine as claimed in claim 1, it is characterized in that: step is as follows:
(1) gets according to the above ratio each raw material: Radix Astragali 2-10 part, Radix Codonopsis 1-5 part, Radix Scrophulariae 1-5 part, Radix Salviae Miltiorrhizae 1-5 part, Radix Adenophorae (Radix Glehniae) 1-5 part, Radix Sophorae Flavescentis 0.5-3 part, Radix Glycyrrhizae Preparata 0.5-3 part;
(2) adding 6-12 times of water gaging decocts 1-4 time, each 0.5-4 hour, collecting decoction filtered, filtrate is concentrated into the clear paste of relative density 1.1～1.3, add ethanol and carry out precipitate with ethanol, alcohol is sink to ethanol content and reaches 40-80%, leaves standstill to place 48 hours, draw supernatant, concentrate, namely get the extract that contains above-mentioned seven flavor Chinese medicines, for subsequent use.
3. the preparation technology of the ARR Chinese medicine for the treatment of according to claim 2 is characterized in that: be prepared into tablet, pill, capsule, solution, oral liquid, buccal tablet, granule, electuary, powder, suspensoid or powder.
4. according to claim 2 or the preparation technology of the ARR Chinese medicine of 3 described treatments, it is characterized in that: in step (2), be concentrated into the thick paste of relative density 1.1～1.4, obtain containing the extract thick paste of above-mentioned seven flavor Chinese medicines; When the preparation dropping pill formulation, add the pharmaceutically suitable carrier as substrate in the extract thick paste, mixing and get final product, the ratio of extract and substrate is counted 1:0.5～1:10 according to weight portion, and described substrate is that in PEG400, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000, PEG 20000, the glycerin gelatine one or more mix; When the preparation granule, in the extract thick paste, add adjuvant, mixing and get final product, the ratio of extract and adjuvant is counted 1:0.5～1:10 according to weight portion, and described adjuvant is that in dextrin, starch, sucrose, lactose, cellulose family, sweeting agent, the lubricant one or more mix.
5. the preparation technology of the ARR Chinese medicine for the treatment of according to claim 4 is characterized in that: during the preparation dropping pill formulation, the condensing agent of use is liquid paraffin, methyl-silicone oil, the mixing of any one in the vegetable oil or more than one.
6. according to claim 2 or the preparation technology of the ARR Chinese medicine of 3 described treatments, it is characterized in that: when the preparation tablet, in the extract by above-mentioned seven flavor Chinese medicines of containing of obtaining in the step (2) after drying, add adjuvant, the ratio of extract and adjuvant is counted 1:0.5～1:10 according to weight portion, and described adjuvant is that in cellulose family, dextrin, lactose, starch, sweeting agent, the lubricant one or more mix.
7. according to claim 2 or the preparation technology of the ARR Chinese medicine of 3 described treatments, it is characterized in that: when the preparation honeyed pill, with each raw material pulverizing for subsequent use in the step (1), cross the 40-80 mesh sieve, add Mel, mixing is made honeyed pill and is got final product; The mass ratio of described mixing medicinal powder and Mel is 1: 0.5～1: 5.
8. the purposes of the ARR Chinese medicine for the treatment of according to claim 1 is characterized in that: as treatment arrhythmia, the application of ventricular premature contraction medicine.
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| CN103751395A (en) * | 2014-01-03 | 2014-04-30 | 黄显娥 | Traditional Chinese medicine for treating ventricular premature beat |
| CN110898102A (en) * | 2019-09-10 | 2020-03-24 | 中国人民解放军北部战区总医院 | Cinnamon extract and traditional Chinese medicine compound for preventing and treating cold injury and application thereof |
| CN112618670A (en) * | 2021-02-22 | 2021-04-09 | 王玉梅 | Traditional Chinese medicine composition for treating premature beat and application thereof |
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