CN102961250A - Multi-component container and external preparation for treating acne - Google Patents
Multi-component container and external preparation for treating acne Download PDFInfo
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- CN102961250A CN102961250A CN201210381893XA CN201210381893A CN102961250A CN 102961250 A CN102961250 A CN 102961250A CN 201210381893X A CN201210381893X A CN 201210381893XA CN 201210381893 A CN201210381893 A CN 201210381893A CN 102961250 A CN102961250 A CN 102961250A
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Abstract
The invention provides a multi-component container with a mixing device. The invention also provides an external preparation for treating acne on the basis of the multi-component container. The external preparation provided by the invention can effectively prevent the degradation of active ingredients in Acanya compound preparations and can obviously increase the stability of all ingredients; the storage time of the preparation can be prolonged without refrigerating; the storage cost of the product is lowered; and the portability and use comfort level of the product are greatly increased. Meanwhile, the multi-component container provided by the invention can be used for finishing the steps of mixing and extruding drugs in a device, so that the time is saved and the inconformity and waste of the product caused by manual mixing are avoided.
Description
Technical field
The present invention relates to the external preparation of a kind of many components container and Acne treatment.
Background technology
Acne is a kind of common dermatosis, and the multiple adolescence of being born in is again comedo, acne.The factor that acne occurs is varied, but the most direct factor is pore to be stopped up, and after pore stopped up, the oils and fats row of hair follicle the inside was not out, because follicular orifice is blocked, the hair follicle luminal stenosis forms anaerobic condition, makes a large amount of hypertrophy of intrafollicular anaerobe, cause microorganism unbalance, human body starts inflammatory mediator, and acne redden, and have just formed acne.
Now have the preparation of multiple Acne treatment, major part is the independent preparation of benzoyl peroxide or itself and some antibiotic compositionss, but use separately benzoyl peroxide to have the zest problem, can cause the general red of skin and affect the observation that the patient improves the initial stage acne.Therefore, because the problem of stimulus object, the benzoyl peroxide treatment is invalid to some patient, and benzoyl peroxide also can cause the problems such as xerosis cutis, peeling when being used for the treatment of acne.
Because the problem that benzoyl peroxide exists, the medicine worker is used in combination Acne treatment with benzoyl peroxide and some drugs, such as United States Patent (USP) 4497794, a kind of compositions that contains benzoyl peroxide and erythromycin, the commodity of said preparation are called Benzamycin, be widely used for Acne treatment, be considered in some cases more effective than independent use benzoyl peroxide.After this, U.S. Valeant drugmaker produces the gel compound preparation that listing contains clindamycin phosphate and these two kinds of active medicines of benzoyl peroxide, be the anti-acne gel compound preparation of latest generation, commodity are called Acanya, and the probability that untoward reaction appears in this product is lower than 0.2%.
But the inventor studies discovery, and in the hybrid packed Acanya compound gel, the content of clindamycin phosphate and benzoyl peroxide meeting fast reducing shows that namely there is defective in the stability of this gel.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of many components container.Another object of the present invention is to provide a kind of acne external preparation that has good stability.
The invention provides a kind of many components container with mixing arrangement, comprise at least two independent storage compartments, propeller, mixing arrangement, wherein said propeller is arranged in the bottom enclosure, described storage compartment is arranged in the upper case, the top of described storage compartment is provided with charge door and capping, what described upper case slided is nested in the bottom enclosure, the bottom of described storage compartment is pressed on the described propeller, described mixing arrangement is arranged on the top of upper case, and described mixing arrangement top-side is provided with discharging opening, and the charging aperture of described mixing arrangement is communicated with the discharging opening of described storage compartment.
Described mixing arrangement is made of barrel shrond and inner helical duct.
The lateral surface of described container upper case is provided with scale.
Further, described propeller is nested in the top of described mixing arrangement, the discharging opening that is arranged on described angle of rake upper side is communicated with the discharging opening of described mixing arrangement by pipeline, be provided with spring between described propeller and the described mixing arrangement, described spring is stage clip, set up suction pipe in the storage compartment, the upper port of described suction pipe is communicated with the charging aperture of described mixing arrangement, and the lower port of described suction pipe reaches the bottom of described storage compartment.
Further, each storage compartment is measure-alike; The discharging opening of each storage compartment is measure-alike.
The present invention also provides a kind of external preparation of Acne treatment, and the effective ingredient of described external preparation is BP and clindamycin phosphate, and two kinds of effective ingredient place separately respectively in the different storage compartments of above-mentioned many components container.
Wherein, described external preparation is gel.
Further, described gel is that supplementary material by following weight proportion is prepared from:
Component A:
Benzoyl peroxide 5-10 part, aqueous gel substrate 10-20 part, antiseptic 0.1-0.5 part, water 70-85 part; PH adjusting agent is regulated pH to 5.0 ~ 7.0;
B component:
Clindamycin phosphate 2-5 part, aqueous gel substrate 10-20 part, antiseptic 0.1-0.5 part, water 75-88 part; PH adjusting agent is regulated pH to 5.0 ~ 7.0.
Wherein, described aqueous gel substrate is one or more the combination in glycerol, propylene glycol, carbomer, cellulose derivative, alginate, tragakanta, the gelatin;
Described antiseptic is one or more the combination in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, sorbic acid, the sodium benzoate;
Described pH adjusting agent is one or more the combination in sodium hydroxide, the potassium hydroxide.
Further, described gel is that supplementary material by following percentage by weight is prepared from:
Component A:
Benzoyl peroxide 5-10 part, 1.25 parts of carbomers, 10 parts of propylene glycol, 0.2 part of methyl hydroxybenzoate, 0.05 part of propylparaben, water 78.5-83.5 part; Potassium hydroxide is regulated pH to 5.0 ~ 7.0;
B component:
2.4 parts of clindamycin phosphates, 1.25 parts of carbomers, 10 parts of propylene glycol, 0.2 part of methyl hydroxybenzoate, 0.05 part of propylparaben, 86.1 parts in water; Potassium hydroxide is regulated pH to 5.0 ~ 7.0.
The present invention also provides the preparation method of above-mentioned external preparation, and it comprises following operating procedure:
(1) takes by weighing supplementary material by proportioning;
(2) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the carbomer that adds recipe quantity fully stirs swelling, add again the benzoyl peroxide of recipe quantity and methyl hydroxybenzoate, propylparaben, stirring is uniformly dispersed it, potassium hydroxide is transferred pH to 5.0 ~ 7.0, add the residue aqueous solution of propylene glycol to full dose, get component A;
(3) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the clindamycin phosphate that adds recipe quantity makes its dissolve complete, the carbomer that adds again recipe quantity, stirring makes its abundant swelling, after adding methyl hydroxybenzoate, propylparaben, regulate pH to 5.0 ~ 7.0 with potassium hydroxide, add the residue aqueous solution of propylene glycol to full dose, get B component;
(4) with component A with in B component places separately respectively the different storage compartments of above-mentioned many components container, encapsulation.
In the present invention's prescription, the viscosity of component A, B is suitable, and each storage compartment's size and each discharging opening are measure-alike in the multiple component containers in addition, has guaranteed that two of patient's use become divided doses consistent.
Gel provided by the invention, can effectively avoid the degraded of effective ingredient in the Acanya compound preparation, significantly improve each ingredient stability, need not cold preservation and can prolong the preparation resting period, reduce the cost of storage of product, greatly increased portability and the comfort of product; Simultaneously, multiple component containers provided by the invention can make the medicament mixed extrusion step finish in device inside, has not only saved the time, and avoids the artificial inconsistent and waste of the product that causes that mixes.
Description of drawings
The propeller of Fig. 1 multiple component containers of the present invention is located at the polycrystalline substance sketch map;
The propeller of Fig. 2 multiple component containers of the present invention is located at the superstructure sketch map;
The propeller of Fig. 3 multiple component containers of the present invention melt with mixing arrangement in structural representation;
Among the figure: the 1-bottom enclosure, the 2-upper case, the B of 3-storage compartment, the 4-helical duct, the 5-mixing arrangement,
6-charge door and capping, the A of 7-storage compartment, 8-propeller, 9-spring, the B of 10-storage compartment suction pipe, the A of 11-storage compartment suction pipe.
The specific embodiment
Many components container of embodiment 1 band mixing arrangement of the present invention
Below in conjunction with accompanying drawing the present invention is described in further detail.
Such as Fig. 1, a kind of many components container with mixing arrangement provided by the invention, comprise at least two independent storage compartments 3,7, propeller 8, mixing arrangement 5, wherein said propeller 8 is arranged in the bottom enclosure 1, described storage compartment 3,7 are arranged in the upper case 2, described storage compartment 3,7 top is provided with charge door and capping 6, what described upper case 2 slided is nested in the bottom enclosure 1, described storage compartment 3,7 bottom is upward sliding under the effect of described propeller 8, described mixing arrangement 5 is arranged on the top of upper case 1, described mixing arrangement 5 top-side are provided with discharging opening, the charging aperture of described mixing arrangement 5 and described storage compartment 3,7 discharging opening is communicated with.Different component substance is contained in the different storage compartments, presses in use mixing arrangement 5 downwards and gets final product.Certainly those skilled in the art also can bottom propeller 8 by simple distortion, move to tip position with it, as shown in Figure 2.
Preferably, described mixing arrangement 5 mainly is made of barrel shrond and inner helical duct 4.Helical duct has prolonged the incorporation time of component, makes the more even, abundant of component mixing.
Preferably, the lateral surface of described container upper case 2 is provided with scale.Can control more accurately each consumption, improve the utilization rate of component.
Further, such as Fig. 3, described propeller 8 is nested in the top of described mixing arrangement 5, and the discharging opening of the upper side of described propeller 8 is communicated with by the discharging opening of pipeline with described mixing arrangement 5, be provided with spring 9 between described propeller 8 and the described mixing arrangement 5, described spring 9 is stage clips.Press in use propeller 8 downwards, the component that mixes in the mixing arrangement 5 is just discharged from the discharging opening of the upper side of propeller 8, after unclamping propeller 8, under the effect of spring 9, propeller 8 is resetted, and simultaneously different component A, B enters into again to be mixed in the mixing arrangement 5 by the A of storage compartment suction pipe 11, the B of storage compartment suction pipe 10 respectively and uses ready next time.This malformation has reduced the overall volume of container, is convenient to store and transportation.
When the present invention uses, at first open the capping of the charge door of storage compartment, the component that fill is different, fill is finished, and builds capping.This moment, container by physically-isolated method, intercepted its reaction each other with interactional material; Again by the top of squeeze receptacle, make component mix rear the discharge before use, can save time so that the mixing extrusion step is finished in device inside, and avoid artificially mixing the inconsistent and waste of the product that causes; And product with existing mixed, can reach the purpose that improves its each autostability, extends the shelf life for existing.
Further, each storage compartment is measure-alike, and this has guaranteed that also the material volume that squeezes out from different storage compartments is also identical.
Further, the discharging opening size of each storage compartment is all identical, and this is identical with regard to the suffered pressure of the material that can guarantee to be squeezed out, and guarantees the uniformity of mixing.
In the compound preparation that is formed by multi-medicament, the problem such as having greatly can be because the wherein interaction of composition and cause product can not stablize in a long time, and the shelf-life is short.For solving problems, conventional way is to add various additives in product, brings so again new problem, makes the production cost of product improve the serious performance that may affect product, the side effect that particularly may cause.For fear of problems, the preparation that many components consist of adopts a plurality of packings separately usually, mix again before use, although can prolong like this shelf-life of product, inconvenient to use.The present invention is simple and reliable for structure, adopt the container of this structure, by physically-isolated method, be used for two or more components are just mixed before use, easy to operate, can effectively reduce reacting to each other between the medicine, reach product and keep in a long time stable, use no or little additive, improved the quality of product, reduced production cost, used simultaneously easy to operate.
The preparation of the gel of embodiment 2 Acne treatments of the present invention
Prescription:
| Component | Component A weight (g) | B component weight (g) |
| Benzoyl peroxide | 5.0 | 0 |
| Clindamycin phosphate | 0 | 2.4 |
| Carbomer | 1.25 | 1.25 |
| Propylene glycol | 10.0 | 10.0 |
| Methyl hydroxybenzoate | 0.2 | 0.2 |
| Propylparaben | 0.05 | 0.05 |
| Water | 83.5 | 86.1 |
| Potassium hydroxide is regulated pH | pH=5.0 | pH=5.0 |
Preparation method:
(1) takes by weighing supplementary material by proportioning;
(2) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the carbomer that adds recipe quantity fully stirs swelling, adds the benzoyl peroxide of recipe quantity and methyl hydroxybenzoate, propylparaben again, stirring is uniformly dispersed it, potassium hydroxide is transferred pH to 5.0, adds the residue aqueous solution of propylene glycol to full dose, gets component A;
(3) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the clindamycin phosphate that adds recipe quantity makes its dissolve complete, the carbomer that adds again recipe quantity, stirring makes its abundant swelling, after adding methyl hydroxybenzoate, propylparaben, regulate pH to 5.0 with potassium hydroxide, add the residue aqueous solution of propylene glycol to full dose, get B component;
(4) with component A with in B component places separately respectively the different storage compartments of embodiment 1 described many components container, encapsulation.
The preparation of embodiment 3 Acne treatment gels of the present invention
Prescription:
| Component | Gel A weight (g) | Gel B weight (g) |
| Benzoyl peroxide | 10.0 | 0 |
| Clindamycin phosphate | 0 | 2.4 |
| Carbomer | 1.25 | 1.25 |
| Propylene glycol | 10.0 | 10.0 |
| Methyl hydroxybenzoate | 0.2 | 0.2 |
| Propylparaben | 0.05 | 0.05 |
| Water | 78.5 | 86.1 |
| Potassium hydroxide is regulated pH | pH=5.0 | pH=5.0 |
Preparation method:
(1) takes by weighing supplementary material by proportioning;
(2) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the carbomer that adds recipe quantity fully stirs swelling, adds the benzoyl peroxide of recipe quantity and methyl hydroxybenzoate, propylparaben again, stirring is uniformly dispersed it, potassium hydroxide is transferred pH to 7.0, adds the residue aqueous solution of propylene glycol to full dose, gets component A;
(3) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the clindamycin phosphate that adds recipe quantity makes its dissolve complete, the carbomer that adds again recipe quantity, stirring makes its abundant swelling, after adding methyl hydroxybenzoate, propylparaben, regulate pH to 7.0 with potassium hydroxide, add the residue aqueous solution of propylene glycol to full dose, get B component;
(4) with component A with in B component places separately respectively the different storage compartments of embodiment 1 described many components container, encapsulation.
In the embodiment of the invention 2,3 the prescription, the viscosity of component A, B is suitable, and each storage compartment's size and each discharging opening are measure-alike in the multiple component containers in addition, has guaranteed that two that the patient uses become divided doses consistent.Below specify beneficial effect of the present invention by test example.
The stable contrast experiment of test example 1 gel of the present invention and existing product
(1) medicine:
Of the present invention group: the gel that active component is separately packed of embodiment 2,3 preparations;
Matched group: press the formula preparation gel of embodiment 2, after component A, B are mixed, packing;
Acanya group: i.e. Acanya product.
(2) experimental technique
Get of the present invention group, matched group, Acanya group, together place and carry out accelerated stability under 40 ℃, RH75% condition and investigate, and increase synchronously the parallel investigation of reference preparation.Wherein the present invention separately two gel components of packing after each sample point is with the 1:1 mixing, take a sample, carry out each main constituent content detection, it is as follows that each product stability is investigated result:
Table 1
Annotate: BPO---benzoyl peroxide; CP---clindamycin phosphate
By the above results as can be known, investigate in the experiment at accelerated stability, benzoyl peroxide, clindamycin phosphate content are significantly higher than matched group (hybrid packed) and Acanya product in the gel of the embodiment of the invention 2,3 preparations.
Experiment shows, gel of the present invention can effectively be avoided the degraded of effective ingredient in the Acanya compound preparation, significantly improves each ingredient stability, need not cold preservation and can prolong the preparation resting period, reduce the cost of storage of product, greatly increased portability and the comfort of product.
The study on the stability of the gel of each device preparation of test example 2 the present invention
Get three devices of Fig. 1-3, prepare gel by the method for embodiment 2, light pressure device top obtains mixing rear product, and each device is chosen three duplicate samples, relatively its outward appearance and medicament contg thereof, and the result is as follows:
Table 2
Annotate: BPO---benzoyl peroxide; CP---clindamycin phosphate
By the above results as can be known, the gel that the various devices of the present invention prepare is extruded medicament appearance and medicament contg homogeneous, without obviously difference between batch is other, shows that various device effect provided by the invention is suitable.
In sum, external preparation provided by the invention, can effectively avoid the degraded of effective ingredient in the Acanya compound preparation, significantly improve each ingredient stability, need not cold preservation and can prolong the preparation resting period, reduce the cost of storage of product, greatly increased portability and the comfort of product; Simultaneously, multiple component containers provided by the invention can make the medicament mixed extrusion step finish in device inside, has not only saved the time, and avoids the artificial inconsistent and waste of the product that causes that mixes.
Claims (10)
1. many components container with mixing arrangement, comprise at least two independent storage compartments (3,7), propeller (8), mixing arrangement (5), it is characterized in that: propeller (8) is arranged in the bottom enclosure (1), storage compartment (3,7) be arranged in the upper case (2), the top of storage compartment (3,7) is provided with charge door and capping (6), and what upper case (2) slided is nested in the bottom enclosure (1), storage compartment (3,7) bottom is pressed on the propeller (8), and mixing arrangement (5) is arranged on the top of upper case (2), and mixing arrangement (5) top-side is provided with discharging opening, the discharging opening of the charging aperture of mixing arrangement (5) and storage compartment (3,7) is communicated with.
2. the many components container with mixing arrangement according to claim 1 is characterized in that: described mixing arrangement (5) is made of barrel shrond and inner helical duct (4).
3. the many components container with mixing arrangement according to claim 1, it is characterized in that: the lateral surface of described upper case (2) is provided with scale.
4. the many components container with mixing arrangement according to claim 1, it is characterized in that: described propeller (8) is nested in the top of mixing arrangement (5), the discharging opening that is arranged on the upper side of propeller (8) is communicated with by the discharging opening of pipeline with mixing arrangement (5), be provided with spring (9) between propeller (8) and the mixing arrangement (5), spring (9) is stage clip, storage compartment (3,7) set up suction pipe (10 in, 11), the upper port of suction pipe (10,11) is communicated with suction pipe (10 with the charging aperture of mixing arrangement (5), 11) lower port reaches the bottom of storage compartment (3,7).
5. the many components container with mixing arrangement according to claim 1, it is characterized in that: each storage compartment is measure-alike; The discharging opening of each storage compartment is measure-alike.
6. the external preparation of an Acne treatment, it is characterized in that: the effective ingredient of described external preparation is BP and clindamycin phosphate, and two kinds of effective ingredient place separately respectively in the different storage compartments of the described many components container of claim 1-5 any one.
7. external preparation according to claim 6, it is characterized in that: described external preparation is gel, described gel is that the supplementary material by following weight proportion is prepared from:
Component A:
Benzoyl peroxide 5-10 part, aqueous gel substrate 10-20 part, antiseptic 0.1-0.5 part, water 70-85 part; PH adjusting agent is regulated pH to 5.0 ~ 7.0;
B component:
Clindamycin phosphate 2-5 part, aqueous gel substrate 10-20 part, antiseptic 0.1-0.5 part, water 75-88 part; PH adjusting agent is regulated pH to 5.0 ~ 7.0.
8. external preparation according to claim 7 is characterized in that: described aqueous gel substrate is one or more the combination in glycerol, propylene glycol, carbomer, cellulose derivative, alginate, tragakanta, the gelatin;
Described antiseptic is one or more the combination in methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, sorbic acid, the sodium benzoate;
Described pH adjusting agent is one or more the combination in sodium hydroxide, the potassium hydroxide.
9. it is characterized in that according to claim 7 or 8 described external preparation: described gel is that the supplementary material by following percentage by weight is prepared from:
Component A:
Benzoyl peroxide 5-10 part, 1.25 parts of carbomers, 10 parts of propylene glycol, 0.2 part of methyl hydroxybenzoate, 0.05 part of propylparaben, water 78.5-83.5 part; Potassium hydroxide is regulated pH to 5.0 ~ 7.0;
B component:
2.4 parts of clindamycin phosphates, 1.25 parts of carbomers, 10 parts of propylene glycol, 0.2 part of methyl hydroxybenzoate, 0.05 part of propylparaben, 86.1 parts in water; Potassium hydroxide is regulated pH to 5.0 ~ 7.0.
10. the preparation method of the described external preparation of claim 9, it is characterized in that: it comprises following operating procedure:
(1) takes by weighing supplementary material by proportioning;
(2) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the carbomer that adds recipe quantity fully stirs swelling, add again the benzoyl peroxide of recipe quantity and methyl hydroxybenzoate, propylparaben, stirring is uniformly dispersed it, potassium hydroxide is transferred pH to 5.0 ~ 7.0, add the residue aqueous solution of propylene glycol to full dose, get component A;
(3) getting propylene glycol is dissolved in water and is mixed with aqueous solution of propylene glycol; Get 90% of aqueous solution of propylene glycol total amount, the clindamycin phosphate that adds recipe quantity makes its dissolve complete, the carbomer that adds again recipe quantity, stirring makes its abundant swelling, after adding methyl hydroxybenzoate, propylparaben, regulate pH to 5.0 ~ 7.0 with potassium hydroxide, add the residue aqueous solution of propylene glycol to full dose, get B component;
(4) with component A with in B component places separately respectively the different storage compartments of the described many components container of claim 1-5 any one, encapsulation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210381893.XA CN102961250B (en) | 2012-10-10 | 2012-10-10 | Multi-component container and external preparation for treating acne |
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|---|---|---|---|
| CN201210381893.XA CN102961250B (en) | 2012-10-10 | 2012-10-10 | Multi-component container and external preparation for treating acne |
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| CN102961250A true CN102961250A (en) | 2013-03-13 |
| CN102961250B CN102961250B (en) | 2014-12-10 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729722A (en) * | 2016-11-21 | 2017-05-31 | 江苏山信药业有限公司 | A kind of method and compound preparation for preparing stabilization compound preparation |
| CN107737135A (en) * | 2017-11-28 | 2018-02-27 | 江苏万川医疗健康产业集团有限公司 | A kind of pharmaceutical preparation and preparation method and application |
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| US4318907A (en) * | 1978-04-04 | 1982-03-09 | Westwood Pharmaceuticals, Inc. | Method for treating acne vulgaris and compositions useful for that purpose |
| CN1077887A (en) * | 1992-02-18 | 1993-11-03 | 劳埃德·J·巴鲁迪 | The compositions that contains benzoyl peroxide and clindamycin that is used for the treatment of acne |
| CN1764437A (en) * | 2003-01-23 | 2006-04-26 | 埃德科贸易和代理有限公司 | Topical pharmaceutical and/or cosmetic dispense systems |
| CN102235572A (en) * | 2010-05-04 | 2011-11-09 | 贺利氏医疗有限公司 | Cartridge system with compressed gas cartridge |
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2012
- 2012-10-10 CN CN201210381893.XA patent/CN102961250B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4056611A (en) * | 1973-04-16 | 1977-11-01 | Stiefel Laboratories, Inc. | Therapeutic composition |
| US4318907A (en) * | 1978-04-04 | 1982-03-09 | Westwood Pharmaceuticals, Inc. | Method for treating acne vulgaris and compositions useful for that purpose |
| CN1077887A (en) * | 1992-02-18 | 1993-11-03 | 劳埃德·J·巴鲁迪 | The compositions that contains benzoyl peroxide and clindamycin that is used for the treatment of acne |
| CN1764437A (en) * | 2003-01-23 | 2006-04-26 | 埃德科贸易和代理有限公司 | Topical pharmaceutical and/or cosmetic dispense systems |
| CN102235572A (en) * | 2010-05-04 | 2011-11-09 | 贺利氏医疗有限公司 | Cartridge system with compressed gas cartridge |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729722A (en) * | 2016-11-21 | 2017-05-31 | 江苏山信药业有限公司 | A kind of method and compound preparation for preparing stabilization compound preparation |
| CN106729722B (en) * | 2016-11-21 | 2020-05-12 | 成都山信药业有限公司 | Method for preparing stable compound preparation and compound preparation |
| CN107737135A (en) * | 2017-11-28 | 2018-02-27 | 江苏万川医疗健康产业集团有限公司 | A kind of pharmaceutical preparation and preparation method and application |
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| CN102961250B (en) | 2014-12-10 |
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