CN103068341A - 二尖瓣假体 - Google Patents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
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- A61F2/2436—Deployment by retracting a sheath
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Abstract
提供了装置,包括在目标的原生二尖瓣联合体处植入的二尖瓣假体(100)。该假体包括具有下游部分(112)和上游部分(116)的内支承结构(102),上游部分的横截面面积大于下游部分的横截面面积,内支承结构构造成至少部分地定位在原生瓣膜联合体的心房侧上,并施加朝向左心室的轴向力。假体还包括外支承结构(104),该外支承结构具有两个或更多个接合臂(106),接合臂联接到内支承结构。该假体构造成在其移植时将原生瓣膜的小叶的一部分夹在内支承结构与接合臂之间。还描述了其他实施例。
Description
相关申请的交叉引用
本申请要求2010年2月24日提交的题为“二尖瓣假体及移植方法”的美国临时申请61/307,743的权益,该申请以参考的方式纳入本文。
发明的实施例的领域
本发明的某些应用总体涉及可移植的医疗装置。具体来说,本发明的某些应用涉及与人工心脏瓣膜相关联的装置和方法。
背景技术
二尖瓣具有两种类型的病状:回流和狭窄。两种缺陷中,回流更普遍。任一种缺陷可以通过外科手术修补来治疗。在某些情形下,必须更换二尖瓣。二尖瓣更换的标准方法要求切开心脏的左侧以通入原生二尖瓣。
授予Tuval的US 2008/0071368描述了在原生瓣膜联合体的原生半月形瓣处移植的假体。该假体包括远端固定件,该远端固定件构造成定位在动脉下游并且形状做成便于正确地限定三个近端接合臂并组合地对限定半月形窦的组织施加朝向心室的第一轴向力,该三个近端接合臂构造成至少部分地定位在半月形窦的对应一个内。该假体还包括联接到远端固定件的近端固定件,近端固定件构造成至少部分地定位在原生半月形瓣的心室侧上并对原生瓣膜联合体的心室侧施加朝向动脉下游的第二轴向力,使得第一和第二力的施加将假体联接到原生瓣膜联合体。
授予Rowe的US 2009/0276040描述了假体二尖瓣组件及其插入方法。在某些实施例中,假体二尖瓣组件具有外扩的上端和锥形部分以符合原生二尖瓣的轮廓。假体二尖瓣组件可包括具有安装在其中的瓣膜的支架或外支承框架。该组件描述成适于径向向外膨胀并进入与原生组织接触以形成压配。描述了一个实施例,包括将二尖瓣组件定位在环下方,使得环本身可限制该组件沿朝向左心房的向上方向移动。二尖瓣组件还描述为定位成使得二尖瓣小叶保持该组件以防止该组件朝向左心室的向下移动。
授予Chau的US 2010/0217382描述了假体二尖瓣组件及其插入方法。在某些实施例中,假体二尖瓣组件包括支架和瓣膜组合。该支架被设计成使得锚固部分定位在二尖瓣的环上方且在左心房中。支架可径向地膨胀,以便该支架可抵靠左心房的壁而膨胀入位置并适应大范围解剖结构。支架与左心房中原生组织之间的接触被描述为减少瓣周泄漏并防止支架一旦就位后移动。
授予Goetz的US 2009/0005863描述了移植在发生故障的原生心脏瓣膜的孔口中心内的更换瓣膜。该瓣膜设计成最小化侵入穿过患者胸腔中的肋间开口和人体心脏的尖端中的开口。更换瓣膜包括单独锚固件或组合锚固件,该锚固件围绕发生故障的原生瓣膜小叶折叠,以便于将更换瓣膜牢固地锚固在精确的、所要求的位置的方式将发生故障的原生瓣膜小叶夹在中间。
授予Straubinger的US 2009/0216312描述了将瓣膜状假体定位和锚固在患者的心脏的移植位置中的支架。具体来说,Straubinger申请涉及用于在心脏瓣膜狭窄和/或心脏瓣膜闭锁不全的治疗中使用的假体的可膨胀支架。该支架描述为包括至少一个紧固部分,瓣膜状假体通过该紧固部分可连接到支架,从而确保固定到支架的瓣膜状假体在支架的已植入状态中,甚至假设心脏的蠕动运动时也没有出现相对于支架的纵向移位。该支架还包括定位弓和保持弓,由此至少一个定位弓经由第一连接腹板连接到至少一个保持弓。该支架还包括至少一个副保持弓,该至少一个副保持弓连接到至少一个保持弓的对应臂,该至少一个保持弓连接到至少一个定位弓。
授予Guyenot的US 2008/0255660描述了治疗心脏瓣膜闭锁不全的医疗设备,具有可被引入患者身体并膨胀以将心脏瓣膜假体固定如患者主动脉的假体。在一实施例中,该假体具有构造成相对于患者主动脉定位的多个定位弓和构造成支承心脏瓣膜假体的多个保持弓。该假体包括在将其引入患者身体的过程中的第一塌缩模式和当其移植后的第二膨胀模式。
下面的参考可能是感兴趣的:
授予Bobo的US 2010/0030330
授予Straubinger的US 2009/0216313
授予Straubinger的US 2009/0216310
授予Straubinger的US 2008/0255661
授予Antocci的US 2008/0208328
授予Tuval的US 2008/0071369
授予Tuval的US 2008/0071363
授予Tuval的US 2008/0071366
授予Tuval的US 2008/0071362
授予Tuval的US 2008/0071361
授予Bonhoeffer的US 2003/0036791
授予Figulla的WO 04/019825
发明概述
对于本发明的某些应用,提供了二尖瓣假体和移植该假体的方法。假体通常经导管地,例如心尖地(即通过心脏的顶部)、经心房地(即通过心脏的左心房)、和/或经隔膜地(即通过心脏的隔膜)植入。假体通常包括内支承结构和外支承结构,外支承结构包括接合臂。瓣膜假体通常缝合到内支承结构。
通常,假体放置在原生二尖瓣联合体上,以使得原生小叶夹在内支承结构与接合臂之间。对于某些引用,这样的构造通过防止瓣膜移入心房或心室而防止原生小叶阻塞穿过左心室出流通道(LVOT)的流动,防止原生小叶与假体小叶干涉,以最小瓣周泄漏恢复原生小叶,保持瓣膜假体的正确对准,避免收缩期前向运动,和/或保持瓣膜稳定性。对于某些应用,假体的设计类似于原生瓣膜并支承体内构造中的非圆,该非圆反映原生瓣膜功能。
因此,根据本发明的某些应用,提供了包括用于移植在目标的原生二尖瓣联合体处的二尖瓣假体的装置,该假体包括:
具有下游部分和上游部分的内支承结构,所述上游部分具有大于所述下游部分的横截面面积,所述内支承结构构造成至少部分地定位在所述原生瓣膜联合体的心房侧上,并施加朝向左心室的轴向力;以及
外支承结构,所述外支承结构具有两个或更多个接合臂,所述接合臂联接到所述内支承结构;
该假体构造成在其移植时将原生瓣膜的小叶的一部分夹在内支承结构与接合臂之间。
对于某些应用,所述接合臂与所述内支承结构一体地形成。
对于某些应用,所述接合臂包括前接合臂和后接合臂,所述前接合臂和所述后接合臂构造成分别夹紧所述原生二尖瓣联合体的前小叶和后小叶,且所述前接合臂的长度与所述后接合臂的长度的比率在1.1:1和15:1之间。
对于某些应用,所述比率在1.3:1和2:1之间。
对于某些应用,所述前接合臂的长度在2mm和35mm之间。
对于某些应用,所述前接合臂的长度在15mm和25mm之间。
对于某些应用,所述后接合臂的长度在2mm和35mm之间。
对于某些应用,所述后接合臂的长度在7mm和23mm之间。
对于某些应用,所述外支承结构还包括连接框架,所述外支承结构的所述连接框架构造成联接到所述内支承结构。
对于某些应用,内支承结构形状做成限定多个单元,且所述外支承结构的连接框架形状做成限定具有与所述内支承结构的单元匹配的形状和大小的多个单元。
对于某些应用,所述假体构造成在其移植时通过将所述原生瓣膜的小叶的一部分夹在所述内支承结构与所述接合臂之间以减少原生瓣膜小叶的运动。
对于某些应用,所述假体构造成通过将所述小叶夹在所述接合臂内部而固定所述原生瓣膜小叶。
对于某些应用,所述假体构造成在通过将小叶夹在接合臂内部而防止原生瓣膜小叶的收缩期前向运动。
对于某些应用,所述假体构造成通过将所述小叶夹在接合臂内部而防止所述原生瓣膜小叶与LVOT干涉。
对于某些应用,所述外支承结构还包括覆盖所述接合臂的覆盖件,所述覆盖件构造成减小所述原生小叶的运动。
对于某些应用,该装置还包括假体瓣膜,所述假体瓣膜包括联接到所述内支承结构的假体瓣膜小叶,所述假体构造成使得其在移植时:
所述原生二尖瓣联合体的原生瓣膜小叶的下游端,
接合臂的下游端,以及
所述假体小叶的下游端,
布置在彼此纵向距离小于3mm处,所述纵向距离沿所述假体的纵向轴线的方向测量。
对于某些应用,所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的3mm内。
对于某些应用,所述假体构造成使得在所述假体移植时,所述假体没有突入目标的左心室超过3mm的部分。
对于某些应用,所述假体构造成使得在其移植时:
所述原生二尖瓣联合体的原生瓣膜小叶的下游端,
所述接合臂的下游端,以及
所述假体小叶的下游端,
布置在彼此纵向距离小于1mm处,所述纵向距离沿所述假体的纵向轴线的方向测量。
对于某些应用,所述假体构造成使得在所述假体移植时,所述假体没有突入目标的左心室超过1mm的部分。
对于某些应用,所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的1mm内。
对于某些应用,所述接合臂构造成在所述假体的移植过程中限定其第一构造,并构造成在放置在原生二尖瓣联合体的原生小叶上方后改变形状以限定其第二构造。
所述接合臂中的每个在其第一构造中跨越小于12mm的宽度,而在其第二构造中跨越大于15mm的宽度。
对于某些应用,在所述接合臂的第一构造中,所述接合臂构造成便于在所述假体的移植过程中原生瓣膜联合体起作用。
对于某些应用,在所述接合臂的第一构造中,所述接合臂构造成安装在原生瓣膜联合体的乳头肌之间。
对于某些应用,在所述接合臂的第一构造中,所述接合臂构造成跨越小于8mm的宽度。
对于某些应用,在所述接合臂的第二构造中,所述接合臂构造成跨越大于35mm的宽度。
对于某些应用,
该装置还包括具有假体瓣膜小叶的假体瓣膜,所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的3mm内,
所述接合臂在所述接合臂的下游端处联接到所述内支承结构,以及
从每个接合臂的下游端到上游端的纵向距离小于18mm,所述纵向距离沿所述假体的纵向轴线的方向测量。
对于某些应用,所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的1mm内。
对于某些应用,所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的3mm内。
对于某些应用,所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的1mm内。
对于某些应用,从每个接合臂的下游端到上游端的纵向距离小于12mm。
对于某些应用,从每个接合臂的下游端到上游端的纵向距离小于10mm。
对于某些应用,该装置还包括假体瓣膜,所述假体瓣膜具有联接到所述内支承结构的假体瓣膜小叶,其中,所述假体构造成使得其在移植时:
所述原生二尖瓣联合体的原生瓣膜小叶的下游端和所述接合臂的下游端布置在纵向距离彼此小于3mm处,所述纵向距离沿所述假体的纵向轴线的方向测量,以及
所述内支承结构的下游端和所述假体瓣膜小叶的下游端在所述原生瓣膜小叶的下游端的上游纵向距离至少4mm处,所述纵向距离沿所述假体的纵向轴线的方向测量。
对于某些应用,所述假体构造成使得在其植入时,所述内支承结构的下游端和所述假体瓣膜小叶的下游端在所述原生瓣膜小叶的下游端的上游纵向距离至少10mm处。
对于某些应用,该装置还包括具有假体瓣膜小叶的假体瓣膜,所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的上游的至少4mm处。
对于某些应用,所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的上游的至少10mm处。
从下面的本发明的实施例以及附图的详细说明,将更完整地理解本发明,其中:
附图简介
图1A-D是根据本发明的某些应用的二尖瓣假体的相应视图的示意性说明;
图2A-D是根据本发明的某些应用的二尖瓣假体的相应视图的示意性说明;
图3是根据本发明的某些应用的假体的内可膨胀支承结构的示意性说明;
图4A-F是根据本发明的某些应用的二尖瓣假体的示意性说明;
图5A-B是根据本发明的某些应用的假体的内可膨胀支承结构的示意性说明;
图6A-D是根据本发明的某些应用的假体的内可膨胀支承结构的示意性说明;
图7A-F是根据本发明的某些应用的二尖瓣假体的心尖移植手术的相应步骤的示意性说明;
图8A-F是根据本发明的某些应用的二尖瓣假体的心尖移植手术的相应步骤的示意性说明;
图9是根据本发明的某些应用的植入后的二尖瓣假体的示意性说明;
图10A-D是根据本发明的某些应用的二尖瓣假体的接合臂的示意性说明;
图11A-D是根据本发明的某些应用的接合臂组件的示意性说明;
图12是根据本发明的某些应用的二尖瓣假体的示意性说明;
图13是根据本发明的某些应用的二尖瓣假体的示意性说明;
图14A-B是根据本发明的某些应用的二尖瓣假体的示意性说明;以及
图15A-B是根据本发明的某些应用的二尖瓣假体的示意性说明。
实施例的详述
现参考图1A-D,图1A-D是根据本发明的某些应用的二尖瓣假体100的相应视图的示意性说明。
二尖瓣假体100包括内支承结构102和外支承结构104。外支承结构104包括外接合臂(即外支承臂)106。如图所示,二尖瓣假体100通常包括两个外接合臂106以便自动匹配原生二尖瓣小叶107(如图1B所示)。
缝合到内支承结构102的是假体瓣膜118。对于某些应用,瓣膜118根据授予Tuval的US 2008/0071368中所描述的技术联接到内支承结构102和/或接合臂106,US 2008/0071368以参考的方式纳入本文。瓣膜118可以由生物相容性合成材料、合成聚合物、自体移植组织、异种移植组织或其他替代的材料形成。瓣膜118是双叶牛心包瓣膜、三叶瓣膜或其他合适的瓣膜(例如,具有不同数量的小叶的瓣膜)。
二尖瓣假体100通常放置在目标的原生二尖瓣联合体128处,如图1D所示。如本文(包括权利要求书)所使用的,“原生二尖瓣联合体”包括原生瓣膜小叶、瓣膜的环、腱索(chordae tendineae)、以及乳头肌(papillary muscles)。内支承结构102和接合臂106便于二尖瓣假体相对于原生二尖瓣联合体128固定,例如,由于接合臂与内支承结构之间的原生瓣膜小叶的夹紧。假体瓣膜118以基本上类似于健康原生二尖瓣的方式起作用,即假体瓣膜:
在心脏舒张期间打开以允许血液从目标左心房流到目标左心室,以及
在心脏收缩期间关闭以防止血液沿上游方向从目标的左心室回流到目标的左心房。
图1C示出了在其关闭状态中(即在心脏收缩过程中)的假体瓣膜118。图1C中示出的假体瓣膜具有三个小叶,虽然如上文所述,对于某些应用,瓣膜118具有不同数量的小叶。
如图1B所示,在移植时,二尖瓣假体100放置成使原生二尖瓣小叶107夹在外接合臂106与内支承结构102之间。外接合臂通常通过夹紧原生瓣膜的小叶来固定原生瓣膜的小叶。
当从外支承结构的外部看时,每个外接合臂106通常在外接合臂的与内支承结构102的下游部分112相邻的区域处向下凹陷(即沿下游方向凹陷),例如如图1B所示。接合臂的下游端通常在连合柱108(图1A所示)处会合。对于某些应用,接合臂在连合柱处联接到内支承框架。替代地或附加地,例如根据授予Tuval的US 2008/0071368描述的技术,接合臂和/或内支承结构在连合柱处联接到假体瓣膜118,US 2008/0071368以参考的方式纳入本文。对于某些应用,二尖瓣假体100包括三个接合臂106、三个小叶、和/或三个连合柱108、或不同数量的前述部件。
通常,接合臂106便于将二尖瓣假体锚固和/或定向在所需要的植入位置。具体来说,接合臂防止二尖瓣假体100离开原生二尖瓣联合体128的上游(例如,当瓣膜118在心脏收缩过程中关闭且上游力施加在假体100上)。这因为响应于向上游导向的血液流动沿上游方向推瓣膜假体(例如在心脏收缩过程中),原生二尖瓣联合体的小叶组织107在接合臂上施加向下游导向的力F1(图1B所示)而实现。对于某些应用(例如,图4E-F所示的假体100的构造),原生瓣膜小叶的下游端在接合臂的下游部分上,即在接合臂的在接合臂形成肩部处通过内支承结构102施加向下游导向的力。此外,由于原生小叶被夹在接合臂与内支承结构102之间,原生小叶将假体锚固在位。
通常,当沿假体的纵向轴线方向测量时,接合臂106的下游端105在假体小叶118的下游端119的3mm内(例如1mm内)(参考图1A)。另外,通常,在移植假体时,接合臂106的下游端105在原生瓣膜小叶107的下游端的3mm内(例如1mm内)(参考图1B)。由此,当沿假体的纵向轴线方向测量时,接合臂的下游端、原生瓣膜小叶的下游端、以及假体瓣膜小叶的下游端都通常彼此在3mm内(例如1mm内)。通常,这因为(a)原生瓣膜小叶联接到内支承结构从而假体瓣膜小叶的下游端在接合臂的下游端的3mm内(例如在3mm内)和(b)沿假体的纵向轴线的方向测量纵向距离时,每个接合臂的从下游端105至上游端109的纵向距离D1(图1B所示)小于18mm(例如小于12mm或小于10mm)而实现。另外,通常,接合臂的下游端联接到内支承结构在内支承结构的下游端的3mm(例如1mm内)。
内支承结构102包括下游部分112和上游部分116。内支承结构102通常是非圆柱形的。根据相应应用,内支承结构102的下游部分112以直线方式(即圆柱形并平行于假体100的纵向轴线)形成,或以外扩方式(即原来假体100的纵向轴线岔开)形成。内支承结构的上游部分116通常从假体的纵向轴线向外弯曲,从而上游部分的横截面面积大于下游部分116的横截面面积。内支承结构的上游部分通常宽于在原生环水平处的原生瓣膜段。
通常,内支承结构的非圆柱形形状便于二尖瓣假体在所需要的植入位置的锚固和/或定向。具体来说,内支承结构的上游部分比在原生环水平处的原生瓣膜段宽以防止二尖瓣假体从原生二尖瓣联合体128的下游离开。这因为响应于下游导向血液流动沿下游方向推瓣膜假体,原生二尖瓣联合体128的组织在内支承结构的上游部分上施加上游导向力F2(图1B所示)而实现。此外,由于原生小叶被夹在接合臂与内支承结构102之间,原生小叶将假体锚固在位。
对于某些应用,内支承结构的上游部分比在原生环水平处的原生瓣膜段宽提高了假体100抵靠心房壁的密封。对于某些应用,内支承结构还在原生二尖瓣联合体128的组织上施加径向导向的力,该力便于假体瓣膜锚固和/或定向在所需的植入位置。对于某些应用,内支承结构的上游部分116在原生瓣膜联合体128的组织上施加径向导向力。
通常,当瓣膜假体100被植入原生二尖瓣联合体128时,由围绕结构的解剖学和病理学变化而致使的施加在内支承结构上的机械应力随施加而变化。对于某些应用,相对于做成更圆柱形的内支承结构,非圆柱形的内支承结构抵抗由于施加在内支承结构上的机械应力而导致其形状变化。通过,通过抵抗其形状变化,内支承结构便于假体瓣膜118正确地起作用。
通常,内支承结构102是可膨胀的(例如可自膨胀的)。例如,内支承结构可以由诸如镍钛诺的记忆合金、或另一生物相容性金属形成。类似地,外支承结构104可以由诸如镍钛诺的记忆合金、或另一生物相容性金属形成。根据相应的应用,内支承结构102和外支承结构104一体地形成,或包括彼此附连的分开的模块部件,如本文下面进一步描述的。
对于某些应用,内支承结构102被设计成响应于心动周期中心脏的自然心动而弯曲和变形。替代地,内支承结构102基本上是刚性的以避免在心动周期过程中弯曲或变形。
对于某些应用,内支承结构102包括一个或多个部分,所述一个或多个部分构造成膨胀到受限制的或预定的直径而不是膨胀直到被周围解剖学结构阻止。由此,内支承结构102的一部分(或整体)可具有预定构造,而不考虑周围解剖结构。通常,该预定的构造使得支承结构膨胀成便于与原生瓣膜联合体的组织接触,但不对原生瓣膜联合体的组织施加实质压力。对于某些应用,相对于具有膨胀直到由周围解剖结构阻止的内支承结构的二尖瓣假体,该内支承结构的受控膨胀直径改进了瓣膜的几何形状。通常,内支承结构102的至少一部分(且进一步通常所有的内支承结构)膨胀直到由周围解剖结构阻止。
如图所示(例如图1A、1C和1D),对于某些应用,内支承结构102的下游部分112和上游部分116包括总体钻石形单元103,其将在下文参考图3进一步详细描述。替代地,采用其他形状和构造的单元103,例如下文所讨论的。对于某些应用,单元的连接件的位置与相邻单元的单元的连接件的位置不对称地定位,和/或单元形状做出不对称。对于某些应用,单元的结构件形状做成曲线地。替代地,单元的结构件以大致Z字形构造形成以形成对称或不对称单元。对于某些应用,使用以Z字形构造形成的结构件将与支承件的径向膨胀和收缩关联的应力分布到连接处之间的多个点。根据相应应用,内支承结构包括不同种类单元阵列,或相同种类阵列,或同时包括两者。
通常,单元103的单元高度(H)与单元宽度(W)(图1A和1C示出的H和W)的比率大于0.5:1和/或小于3:1,例如0.5:1至3:1。例如,比率可以大于1.5:1和/或小于2.5:1,例如1.5:1至2.5:1。例如,比率可以大于1.75:1和/或小于2.25:1,例如1.75:1至2.25:1。对于某些应用,使得单元具有前述的单元高度与单元宽度的比率便于内支承结构102的结构的膨胀和/或维护。
现参考图2A-D,图2A-D是根据本发明的某些应用的二尖瓣假体100的相应视图的示意性说明。对于某些应用,前接合臂106A的长度L2大于后接合臂106P的长度L3。对于某些应用,前接合臂和后接合臂的不同长度相对应于大部分人的解剖学,大部分人的原生前二尖瓣小叶要比他们的原生后二尖瓣小叶长。所有的其他方面中,图2A-D示出的二尖瓣假体基本上类似于参考图1A-D描述的二尖瓣假体。
通常,前接合臂的长度L2大于2mm且小于35mm,例如15mm至25mm。还通常,后接合臂的长度L3大于2mm且小于35mm,例如7mm至23mm。还通常地,对于其中前接合臂和后接合臂具有不同长度的应用中,前接合臂的长度与后接合臂的长度的比率大于1.1:1,和/或小于15:1,例如1.3:1至2:1。
现参考图3,图3是根据本发明的某些应用的二尖瓣假体100的内支承结构102的示意性说明。如图3所示,对于某些应用,内支承结构的单元103在沿内支承结构的不同纵向位置处具有相应的特征。
对于某些应用,内支承结构的下游部分112包括具有相对短的高度和相对于高度来说相对高的支柱(strut)宽度。此外,单元通常限定相对高的角度。对于某些应用,具有前述特征的单元为支承结构的下游部分提供了高径向力区域以保持瓣膜的环状,和/或抵抗高压力梯度的耐疲劳性。通常,支承结构的下游部分相对短,从而最小化内支承结构突入心室超过环形平面。
对于某些应用,内支承结构的上游部分116包括中间部分116A和最上游部分116B,中间部分116B布置在最上游部分116A与支承结构的下游部分112之间。中间部分116A和最上游部分116B的单元具有相应的特征。
中间部分116A的单元103通常具有相对短的高度,以及相对于高度来说相对高的支柱宽度。此外,单元通常限定相对高的角度。对于某些应用,具有前述特征的单元为支承结构的中间部分提供高的抗收聚性。支承结构的中间部分通常形状做成以便于环形在该环形上方的二尖瓣联合体的心房侧上的密封。替代地或附加地,支承结构的中间部分形状做成以便于防止二尖瓣假体100的朝下游方向移动。
最上游部分116B的单元103通常具有高的高度。最上游部分的单元的形状通常在周围解剖结构上施加相对低的径向压力,从而支承结构的最上游部分通过符合心房解剖结构而加强原始瓣膜联合体的密封。另外,通过符合心房解剖结构,最上游部分保护心房收缩。支承结构的最上游部分通常具有相对大的横截面面积,这通常防止二尖瓣假体100的向下游方向移动。
现参考图4A-F,图4A-F是根据本发明的某些应用的二尖瓣假体100的示意性说明。如图4A-D所示,对于某些应用,二尖瓣假体100的内支承结构102不延伸到假体的下游端。例如,如图所示,内支承结构可从上游端120延伸到假体的上游端与下游端之间的大致中途,从而内支承结构的下游端在离假体小叶118的下游端119在2mm和15mm之间。替代地,例如,二尖瓣假体100的内支承结构102确实基本上延伸到假体的下游端,从而内支承结构的下游端在假体小叶118的下游端119的1mm内(例如,如图1C所示)。
对于某些应用,外支承结构104包括外接合臂106,外接合臂106联接到连合柱108的上游端而不是联接到连合柱的下游端,如参考图1A-D所描述的。如图4B所示,对于某些应用,连合柱108从接合臂106的端部向下游方向延伸。对于这种应用,连合柱108的下游端与假体瓣膜小叶118的端部齐平。在所有其他方面中,图4B的假体100基本上类似于上文参考图1-3所述的假体100。
对于某些应用,不使得内支承结构延伸到假体的下游端允许假体200由较少材料构成,和/或降低假体200的重量。
如图4E-F所示,对于某些应用,接合臂106和假体瓣膜118联接到支承结构102,从而假体瓣膜小叶的下游端119在接合臂的下游端105的上游纵向距离D2处。由此,假体100构造成使得在其植入时,内支承结构102的下游端和假体瓣膜小叶118的下游端119在原生瓣膜小叶107的下游端的上游纵向距离D2处。通常,距离D2至少4mm,例如至少10mm。还通常,在假体移植时,原生瓣膜联合体的原生瓣膜小叶的下游端和接合臂的下游端105设置在纵向距离彼此小于3mm处
现参考图5A-B,图5A-B是根据本发明的某些应用的二尖瓣假体100的内可膨胀支承结构104的的示意性说明。如图所示,对于某些应用,内支承结构在支承结构的下游端处的顶部(apices)成圆形。图5B示出了稍微圆形的尖端,而图5A示出了更圆形的顶部。对于某些应用,相对于使用具有非圆形上游端的内支承结构来说,使用圆形的顶部降低了对心房心内膜的损伤,和/或加强内支承结构的局部径向刚度。对于某些应用,内支承结构的下游端也具有成圆形单元顶部。可替代的应用中,在内支承结构的下游端处的单元的顶部是非圆形的(如图5A-B所示),或内支承结构的两端处的单元的顶部都是非圆形的(如图1A所示)。
现参考图6A-D,图6A-D是根据本发明的某些应用的二尖瓣假体100的内可膨胀支承结构102的的示意性说明。
图6A-B示出的假体100基本上类似于上文描述的假体,该假体包括内支承结构102和外支承结构104。但是,内支承结构102的形状不同于图1A的内支承结构102的形状。具体来说,内支承结构102的上游部分116不对称地形成以适应心房的前角(其与主动脉瓣膜的位置解剖学地关联),如图6B所示,图6B示出已植入目标心脏的内部的假体。例如,如图6A所示,假体100的从下游部分112至上游部分116的长度在相对应于心房的前角区域处增加。该区域还从假体的纵向轴线进一步径向延伸,以适应前角。如上文所示,上游部分116通常比在原生环水平处的原生瓣膜段宽。这种构造防止假体100移动进入心室并改进假体100抵靠心房壁的密封。
对于某些应用,如图所示,内支承结构的下游部分112具有圆形横截面,而上游部分116具有非圆形横截面。通常,对于其中内支承结构形状做成适应心房的前角的应用,内支承结构102的横截面是不均匀的、非圆形形状,例如D形或卵形。
图6B是穿过人类心脏124的矢状切口(sagittal cut),显示图6A的已植入二尖瓣假体100。布置在左心室127中的腱索126将原生二尖瓣128连接到乳头肌130。接合臂106围绕原生二尖瓣128的小叶107缠绕。如图6B所示,上游部分116具有非圆形、不对称形状以适应心房132的前角,其与主动脉瓣膜134的位置解剖学地关联。上游部分116的形状便于轴向固定,便于防止流出物阻塞,和/或便于假体100抵靠左心房132的壁的密封。
图6C-D示出的假体100基本上类似于上文描述的假体,该假体包括内支承结构102和外支承结构104。但是,根据本发明的某些应用,内支承结构的上游部分116包括固定件190(例如,倒钩,如图所示,钩子、锚固件、或夹子)以提供进一步固定支承和防止假体100移动入心室。
图6D是穿过人类心脏124的矢状切口,显示已植入二尖瓣假体100。如图6D所示,上游部分116具有非圆形、不对称的形状以适应左心房132的前角。上游部分116的形状便于轴向固定,便于防止流出物阻塞,和/或便于假体100抵靠左心房132的壁的密封。另外,倒钩190刺入尖瓣环并用作锁定机构以防止假体100移动进入左心室127。
现参考图7A-F,图7A-F示出根据本发明的某些应用的二尖瓣假体100(上文参考图1-6中任一个所述)的经心尖移植手术的对应步骤的示意性说明。
如图7A所示,套管针(即外管)730穿过形成在患者心脏124的顶部724中的切口而被插入左心室127。扩张器732用于帮助套管针730插入。在该经心尖方法中,从上游方向接近原生二尖瓣128。如图7B所示,随后,套管针730充分地缩回以释放二尖瓣假体的自膨胀接合臂106。通常,扩张器732呈现在瓣膜128的小叶之间。可如所需要地旋转和调节套管针730以对准瓣膜假体,从而接合臂106定位成便于围绕原生瓣膜128的小叶放置。
如图7C所示,随后,套管针730和瓣膜假体向前前进,从而外接合臂106放置在原生瓣膜128的小叶上。如图7D所示,随后,扩张器732前进入左心房以进一步暴露内支承结构,且更具体来说,以开始上游部分116从扩张器732的脱离。图7E示出从扩张器732释放并膨胀以压靠原生二尖瓣128的内壁的上游部分116。上游部分的膨胀通常使得原生瓣膜小叶被夹在内支承结构与接合臂之间。(对于某些应用,上游部分116不膨胀抵靠原生瓣膜的内壁从而在瓣膜的内壁上施加基本上径向力。而是,上游部分构造成通过施加抵靠小叶的向下游方向的轴向力而抵靠接合臂夹住原生小叶。)随后,套管针730从心脏124抽出,且顶部(apex)724中的切口闭合,如图7F所示。
注意,从图7C至7E的转变中,由每个接合臂跨越的宽度W1增加。通常,在接合臂放置在原生瓣膜小叶的过程中,每个接合臂跨越小于12mm的宽度,例如小于8mm,如图7C所示。通常,这防止接合臂进入与乳头肌接触,由于接合臂跨越足够窄的宽度以便于放置在乳头肌之间。还通常,这允许原生瓣膜至少部分继续起作用,因为存在着小叶的在接合臂外的部分可至少部分地打开和闭合。随后,接合臂膨胀(通常由于内支承结构的膨胀)从而每个接合臂跨越超过15mm的宽度,例如超过35mm,如图7E所示。
现参考图8A-F,图8A-F示出根据本发明的某些应用的二尖瓣假体100(上文参考图1-6中任一个所述)的心尖移植手术的对应步骤的示意性说明。
如图8A所示,扩张器732和套管针730插入穿过心脏124的左心房的壁中形成的切口。扩张器732和套管针730前进穿过原生二尖瓣128并进入心脏124的左心室。如图8B所示,随后,扩张器732从套管针732抽出。随后,引导线842前进穿过套管针730到二尖瓣假体100到达套管针730的端部的点,如图8C所示。如图8D所示,随后,二尖瓣假体充分地前进以从套管针730释放自膨胀接合臂106。通常根据需要旋转并调节套管针730以适当地使得瓣膜假体与原生瓣膜128对齐。随后,轻轻地抽出套管针730以围绕原生瓣膜128的小叶的外部放置接合臂106,如图8E所示。随后,从心脏124完全抽出套管针730,从而二尖瓣假体100自膨胀入位置并承担原生二尖瓣128的作用,如图8F所示。
对于某些应用(未示出),假体100(上文参考图1-6中任一个所述)经隔膜地植入。对于这样的应用,假体经由股静脉前进进入右心房。在心脏的隔膜中形成的切口提供到左心房的通路。然后,假体前进穿过隔膜中的切口并通过类似于上文参考图8C-8F描述的技术的技术植入。这种方法通常包括下面的一些或全部:在股静脉中形成切口;将套管针插入穿过股静脉中的切口并将套管针前进入心脏的左心房;在心脏的隔膜中形成切口;将套管针前进穿过心脏的隔膜并进入左心房;将二尖瓣假体前进穿过套管针并进入心脏的左心房;将套管针前进穿过原生二尖瓣并进入心脏的左心室;从套管针释放接合臂;缩回套管针从而接合臂围绕原生二尖瓣小叶的外表面放置;从套管针释放内支承结构;闭合隔膜中的切口;以及从心脏抽出套管针。
现参考图9,图9示出根据本发明的某些应用的已植入的二尖瓣假体100(上文参考图1-6中任一个所述)的的示意性说明。二尖瓣假体100具有夹住原生瓣膜的小叶128的接合臂106。通常,接合臂的下游端限定旋转间隙。当假体移植在原生二尖瓣中时,原生二尖瓣的连合处,以及原生小叶的相邻于该连合处的区域被挤压在外接合臂106的两端之间的间隙中。小叶被挤压在该间隙中从而前小叶和后小叶的相邻于连合处的区域彼此抵靠挤压并密封接合处。
现参考图10A-D,图10A-D是根据本发明的某些应用的二尖瓣假体100的接合臂106的示意性说明。根据相应应用,接合臂106形成U形凹槽110(图10A)、圆形凹槽111(图10B)、膨胀的瓶状凹槽113(图10C),和/或起伏的奶瓶状凹槽槽115(图10D)。对于某些应用(未示出),接合臂形状做成包括两个或更多个平行弓形。
现参考图11A-D,图11A-D是根据本发明的某些应用的外支承结构104的示意性说明。图11A示出包括接合臂106的单个连续结构,接合臂106从外支承结构的连接框架121的对应点出来。如图11B所示,外支承结构放置在内支承结构102上方并联接到内支承结构。对于某些应用,使用接合臂从其出来的单个连续结构确保了接合臂对称地放置在假体上,便于假体的装配,和/或加强了假体的总体框架强度。
如图11A所示,对于某些应用,接合臂包括小叶捕获构件123(例如如图所示的另外的支柱)以便于原生瓣膜小叶的夹紧,由此减少原生二尖瓣小叶的运动、固定原生二尖瓣小叶、和/或防止小叶的收缩期前向运动。通常,通过防止小叶的收缩期前向运动,接合臂防止原生小叶堵塞或与LVOT干涉。对于某些应用,如参考图11A-D所述或本申请中其他地方所述的接合臂106即使在没有小叶捕获构件或任何其他构件的情形中也防止原生小叶的收缩期前向运动。
如图11C-D所示,对于某些应用,整个外支承结构104(图11C)或其一部分(图11D)被生物相容性布145(例如聚酯)覆盖。通常,该覆盖有助于防止原生小叶穿过接合臂106的收缩期前向运动,和/或减小外支承结构与内支承结构之间的金属与金属的摩擦。对于某些应用,该覆盖可基本上帮助捕获可能从原生瓣膜或周围组织离开的钙化、血酸、或其他材料。
现参考图12,图12是根据本发明的某些应用的二尖瓣假体100的示意性说明。如图12所示,假体100基本上类似于上文描述的假体100,除了如图12所示的假体100的接合臂106的下游端直接连接到内支承结构102。如图12所示,接合臂106在内支承结构的下游部分112处附连到内支承结构102。根据某些应用,接合臂106直接附连到内支承结构102在任何合适的位置处,包括但不限于下游部分112、中间部分116A、和/或最上游部分116B(上述的部分通常如上文参考图3所述)。对于某些应用,接合臂与内支承结构一体地形成。
现参考图13,图13是根据本发明的某些应用的二尖瓣假体100的示意性说明。如图13所示,假体100基本上类似于参考图12所描述的假体100。但是,相对于图12所示的假体,图13所示的假体包括大于1mm和/或小于20mm,例如1-20mm(例如,大于10mm和/或小于14mm,例如10-14mm)的更短的下游部分112。此外,相对于图12所示的假体,图13中所示的假体的接合臂106更靠近假体的下游端地附连到内支承结构102。对于某些应用,相对于更长假体的使用,更短假体的使用改进了在装载在递送导管上时假体的可操作性,由此便于这种设备的移植并减少执行移植手术所要求的时间。对于某些应用,相对于更长的假体,更短假体的使用减少了假体与左心室出流通道(LVOT)的干涉。
现参考图14A-B,图14A-B是根据本发明的某些应用的二尖瓣假体100的二尖瓣部分的示意性说明。图14A-B示出包括接合臂106的单个外支承结构104,该接合臂从连续结构的对应点出来。外支承结构的连接框架123包括支柱,该支柱的结构几何形状上类似于内支承结构102上的支柱。对于某些应用,当内支承结构和外支承结构彼此联接时,使用类似于内支承结构上的相对应支柱的支柱加强了假体的框架强度。
根据相应的应用,接合臂106联接到外支承结构104的连接框架123,或该接合臂和该连接框架形成单件连续结构。如上文参考图11A-B所述,对于某些应用,使用接合臂从其出来的单个连续结构确保了接合臂对称地放置在假体上,便于假体的装配,和/或加强了假体的总体框架强度。
如图14B所示,对于某些应用,外支承结构104的至少一部分由生物相容性布145(例如聚酯)覆盖。通常,该覆盖有助于防止原生小叶穿过接合臂106的收缩期前向运动,和/或减小外支承结构与内支承结构之间的金属与金属的摩擦。对于某些应用,该覆盖可基本上帮助捕获可能从原生瓣膜或周围组织离开的钙化、血酸、或其他材料。
现参考图15A-B,图15A-B是根据本发明的某些应用的二尖瓣假体100的示意性说明。对于某些应用,在二尖瓣假体的构造过程中,接合臂106切成内支承结构102的整体部分。使用热处理将接合臂106相对于内支承结构102折叠入位。图15B示出相对于内支承结构已经折叠入位的接合臂。
参考相应附图描述的二尖瓣假体100的特征不限于那些图中所示的假体。而是,任一图中所示的假体的特征可与本文所述的任何其他特征组合使用。可彼此组合的各特征的示例包括但不限于:
●内支承结构102的单元的结构
●图2A-D的非对称接合臂106,
●参考图4A-F描述的内支承结构102和外支承结构104的特征
●参考图5A-B描述的内支承结构102的特征
●如参考图6A-D描述的非对称内支承结构,和内支承结构的固定倒钩
●参考图9-15B描述的外支承结构和/或接合臂的特征。
另外,本文描述的外科手术技术可用于假体100的移植,包括但不限于,例如上文参考图7-8描述的心尖地、经心房地transatrially、经隔膜地移植二尖瓣假体的方法。
如本文所使用的,术语“上游”和“下游”用于指当二尖瓣假体100被植入目标心脏内时血压流动的上游和下游方向。术语“上游”和“下游”应理解成分别与术语“近端”和“远端”可互换的。
本文描述的技术可与下面申请中的一个或多个描述的技术组合,所有的这些申请以参考方式纳入本文:
●授予Tuval的US 2008/0071368
●授予Hill的US 2009/0281618
●授予Hill的US 2010-0036479
本领域的技术人员将理解本发明不限于本文上面已经具体示出和描述的内容。而是,本发明的范围包括上文所述的各特征的组合和子组合,以及本领域的技术人员在阅读前述说明书后将变得明显的不在现有技术中的变型和修改。
Claims (36)
1.包括在目标的原生二尖瓣联合体处植入的二尖瓣假体的装置,所述假体包括:
具有下游部分和上游部分的内支承结构,其中,所述上游部分具有大于所述下游部分的横截面面积,所述内支承结构构造成至少部分地定位在所述原生瓣膜联合体的心房侧上,并施加朝向左心室的轴向力;以及
外支承结构,所述外支承结构具有两个或更多个接合臂,其中,所述接合臂联接到所述内支承结构,
其中,所述假体构造成在其移植时将原生瓣膜的小叶的一部分夹在所述内支承结构与所述接合臂之间。
2.如权利要求1所述的装置,其特征在于:所述接合臂与所述内支承结构一体地形成。
3.如权利要求1所述的装置,其特征在于:所述接合臂包括前接合臂和后接合臂,所述前接合臂和所述后接合臂构造成分别夹紧所述原生二尖瓣联合体的前小叶和后小叶,且其中所述前接合臂的长度与所述后接合臂的长度的比率在1.1:1和15:1之间。
4.如权利要求3所述的装置,其特征在于:所述比率在1.3:1和2:1之间。
5.如权利要求3所述的装置,其特征在于:所述前接合臂的长度在2mm和35mm之间。
6.如权利要求5所述的装置,其特征在于:所述前接合臂的长度在15mm和25mm之间。
7.如权利要求3所述的装置,其特征在于:所述后接合臂的长度在2mm和35mm之间。
8.如权利要求7所述的装置,其特征在于:所述后接合臂的长度在7mm和23mm之间。
9.如权利要求1所述的装置,其特征在于:所述外支承结构还包括连接框架,所述外支承结构的所述连接框架构造成联接到所述内支承结构。
10.如权利要求9所述的装置,其特征在于:内支承结构形状做成限定多个单元,且所述外支承结构的连接框架形状做成限定具有与所述内支承结构的单元匹配的形状和大小的多个单元。
11.如权利要求1所述的装置,其特征在于:所述假体构造成在其移植时通过将所述原生瓣膜的小叶的一部分夹在所述内支承结构与所述接合臂之间以减少原生瓣膜小叶的运动。
12.如权利要求11所述的装置,其特征在于:所述假体构造成通过将所述小叶夹在所述接合臂内部而固定所述原生瓣膜小叶。
13.如权利要求11所述的装置,其特征在于:所述假体构造成在通过将小叶夹在接合臂内部而防止原生瓣膜小叶的收缩期前向运动。
14.如权利要求11所述的装置,其特征在于:所述假体构造成通过将所述小叶夹在接合臂内部而防止所述原生瓣膜小叶与LVOT干涉。
15.如权利要求11所述的装置,其特征在于:所述外支承结构还包括覆盖所述接合臂的覆盖件,所述覆盖件构造成减小所述原生小叶的运动。
16.如权利要求1所述的装置,其特征在于:还包括假体瓣膜,所述假体瓣膜包括联接到所述内支承结构的假体瓣膜小叶,其中,所述假体构造成使得其在移植时:
所述原生二尖瓣联合体的原生瓣膜小叶的下游端,
接合臂的下游端,以及
所述假体小叶的下游端,
布置在彼此纵向距离小于3mm处,所述纵向距离沿所述假体的纵向轴线的方向测量。
17.如权利要求16所述的装置,其特征在于:所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的3mm内。
18.如权利要求16所述的装置,其特征在于:所述假体构造成使得在所述假体移植时,所述假体没有突入目标的左心室超过3mm的部分。
19.如权利要求16所述的装置,其特征在于:所述假体构造成使得在其移植时:
所述原生二尖瓣联合体的原生瓣膜小叶的下游端,
所述接合臂的下游端,以及
所述假体小叶的下游端,
布置在彼此纵向距离小于1mm处,所述纵向距离沿所述假体的纵向轴线的方向测量。
20.如权利要求19所述的装置,其特征在于:所述假体构造成使得在所述假体移植时,所述假体没有突入目标的左心室超过1mm的部分。
21.如权利要求19所述的装置,其特征在于:所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的1mm内。
22.如权利要求1所述的装置,其特征在于:所述接合臂构造成在所述假体的移植过程中限定其第一构造,并构造成在放置在原生二尖瓣联合体的原生小叶上方后改变形状以限定其第二构造。
所述接合臂中的每个在其第一构造中跨越小于12mm的宽度,而在其第二构造中跨越大于15mm的宽度。
23.如权利要求22所述的装置,其特征在于:在所述接合臂的第一构造中,所述接合臂构造成便于在所述假体的移植过程中原生瓣膜联合体起作用。
24.如权利要求22所述的装置,其特征在于:在所述接合臂的第一构造中,所述接合臂构造成安装在原生瓣膜联合体的乳头肌之间。
25.如权利要求22所述的装置,其特征在于:在所述接合臂的第一构造中,所述接合臂构造成跨越小于8mm的宽度。
26.如权利要求22所述的装置,其特征在于:在所述接合臂的第二构造中,所述接合臂构造成跨越大于35mm的宽度。
27.如权利要求1所述的装置,其特征在于:
还包括具有假体瓣膜小叶的假体瓣膜,所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的3mm内,
其中,所述接合臂在所述接合臂的下游端处联接到所述内支承结构,以及
其中,从每个接合臂的下游端到上游端的纵向距离小于18mm,所述纵向距离沿所述假体的纵向轴线的方向测量。
28.如权利要求27所述的装置,其特征在于:所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的1mm内。
29.如权利要求27所述的装置,其特征在于:所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的3mm内。
30.如权利要求29所述的装置,其特征在于:所述接合臂的下游端联接到所述内支承结构在所述内支承结构的下游端的1mm内。
31.如权利要求27所述的装置,其特征在于:从每个接合臂的下游端到上游端的纵向距离小于12mm。
32.如权利要求31所述的装置,其特征在于:从每个接合臂的下游端到上游端的纵向距离小于10mm。
33.如权利要求1所述的装置,其特征在于:还包括假体瓣膜,所述假体瓣膜具有联接到所述内支承结构的假体瓣膜小叶,其中,所述假体构造成使得其在移植时:
所述原生二尖瓣联合体的原生瓣膜小叶的下游端和所述接合臂的下游端布置在纵向距离彼此小于3mm处,所述纵向距离沿所述假体的纵向轴线的方向测量,以及
所述内支承结构的下游端和所述假体瓣膜小叶的下游端在所述原生瓣膜小叶的下游端的上游纵向距离至少4mm处,所述纵向距离沿所述假体的纵向轴线的方向测量。
34.如权利要求33所述的装置,其特征在于:所述假体构造成使得在其植入时,所述内支承结构的下游端和所述假体瓣膜小叶的下游端在所述原生瓣膜小叶的下游端的上游纵向距离至少10mm处。
35.如权利要求1所述的装置,其特征在于:还包括具有假体瓣膜小叶的假体瓣膜,所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的上游的至少4mm处。
36.如权利要求35所述的装置,其特征在于:所述假体瓣膜小叶联接到所述内支承结构,使得所述假体瓣膜小叶的下游端在所述接合臂的下游端的上游的至少10mm处。
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105662651A (zh) * | 2014-12-05 | 2016-06-15 | Nvt股份公司 | 人工心脏瓣膜和用于其的输送系统 |
CN105744915A (zh) * | 2013-11-20 | 2016-07-06 | 詹姆斯·E·科尔曼 | 可调节的心脏瓣膜植入物 |
US10646226B2 (en) | 2013-11-20 | 2020-05-12 | James E. Coleman | Controlling a size of a pyloris |
US11547558B2 (en) | 2016-10-24 | 2023-01-10 | Ningbo Jenscare Biotechnology Co., Ltd. | Heart valve prosthesis anchored to interventricular septum and conveying and releasing method thereof |
Families Citing this family (289)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2462509A1 (en) | 2001-10-04 | 2003-04-10 | Neovasc Medical Ltd. | Flow reducing implant |
IL158960A0 (en) | 2003-11-19 | 2004-05-12 | Neovasc Medical Ltd | Vascular implant |
DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
US8608797B2 (en) | 2005-03-17 | 2013-12-17 | Valtech Cardio Ltd. | Mitral valve treatment techniques |
US8951285B2 (en) | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
AU2006315812B2 (en) | 2005-11-10 | 2013-03-28 | Cardiaq Valve Technologies, Inc. | Balloon-expandable, self-expanding, vascular prosthesis connecting stent |
US8652201B2 (en) * | 2006-04-26 | 2014-02-18 | The Cleveland Clinic Foundation | Apparatus and method for treating cardiovascular diseases |
US9974653B2 (en) | 2006-12-05 | 2018-05-22 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
US11259924B2 (en) | 2006-12-05 | 2022-03-01 | Valtech Cardio Ltd. | Implantation of repair devices in the heart |
EP2142142B1 (en) | 2007-03-05 | 2017-02-08 | Endospan Ltd | Multi-component expandable supportive bifurcated endoluminal grafts and methods for using same |
US11660190B2 (en) | 2007-03-13 | 2023-05-30 | Edwards Lifesciences Corporation | Tissue anchors, systems and methods, and devices |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US8486131B2 (en) | 2007-12-15 | 2013-07-16 | Endospan Ltd. | Extra-vascular wrapping for treating aneurysmatic aorta in conjunction with endovascular stent-graft and methods thereof |
ES2903231T3 (es) | 2008-02-26 | 2022-03-31 | Jenavalve Tech Inc | Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
US8382829B1 (en) | 2008-03-10 | 2013-02-26 | Mitralign, Inc. | Method to reduce mitral regurgitation by cinching the commissure of the mitral valve |
CA2749026C (en) | 2008-09-29 | 2018-01-09 | Impala, Inc. | Heart valve |
US8690936B2 (en) | 2008-10-10 | 2014-04-08 | Edwards Lifesciences Corporation | Expandable sheath for introducing an endovascular delivery device into a body |
US8715342B2 (en) | 2009-05-07 | 2014-05-06 | Valtech Cardio, Ltd. | Annuloplasty ring with intra-ring anchoring |
EP2379008B1 (en) | 2008-12-22 | 2021-02-17 | Valtech Cardio, Ltd. | Adjustable annuloplasty devices |
US8241351B2 (en) | 2008-12-22 | 2012-08-14 | Valtech Cardio, Ltd. | Adjustable partial annuloplasty ring and mechanism therefor |
US10517719B2 (en) | 2008-12-22 | 2019-12-31 | Valtech Cardio, Ltd. | Implantation of repair devices in the heart |
US8911494B2 (en) | 2009-05-04 | 2014-12-16 | Valtech Cardio, Ltd. | Deployment techniques for annuloplasty ring |
US8353956B2 (en) | 2009-02-17 | 2013-01-15 | Valtech Cardio, Ltd. | Actively-engageable movement-restriction mechanism for use with an annuloplasty structure |
WO2010121076A2 (en) | 2009-04-15 | 2010-10-21 | Cardiaq Valve Technologies, Inc. | Vascular implant and delivery system |
US9968452B2 (en) | 2009-05-04 | 2018-05-15 | Valtech Cardio, Ltd. | Annuloplasty ring delivery cathethers |
CA3009244C (en) | 2009-06-23 | 2020-04-28 | Endospan Ltd. | Vascular prostheses for treating aneurysms |
CA2767596C (en) | 2009-07-09 | 2015-11-24 | Endospan Ltd. | Apparatus for closure of a lumen and methods of using the same |
US9730790B2 (en) | 2009-09-29 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Replacement valve and method |
US10098737B2 (en) | 2009-10-29 | 2018-10-16 | Valtech Cardio, Ltd. | Tissue anchor for annuloplasty device |
US9180007B2 (en) | 2009-10-29 | 2015-11-10 | Valtech Cardio, Ltd. | Apparatus and method for guide-wire based advancement of an adjustable implant |
EP3735937A1 (en) | 2009-11-30 | 2020-11-11 | Endospan Ltd. | Multi-component stent-graft system for implantation in a blood vessel with multiple branches |
WO2011067770A1 (en) | 2009-12-02 | 2011-06-09 | Valtech Cardio, Ltd. | Delivery tool for implantation of spool assembly coupled to a helical anchor |
US8449599B2 (en) | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
WO2011070576A1 (en) | 2009-12-08 | 2011-06-16 | Endospan Ltd. | Endovascular stent-graft system with fenestrated and crossing stent-grafts |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
CA2785953C (en) | 2009-12-31 | 2016-02-16 | Endospan Ltd. | Endovascular flow direction indicator |
US9468517B2 (en) | 2010-02-08 | 2016-10-18 | Endospan Ltd. | Thermal energy application for prevention and management of endoleaks in stent-grafts |
US10433956B2 (en) * | 2010-02-24 | 2019-10-08 | Medtronic Ventor Technologies Ltd. | Mitral prosthesis and methods for implantation |
WO2011109813A2 (en) | 2010-03-05 | 2011-09-09 | Edwards Lifesciences Corporation | Retaining mechanisms for prosthetic valves |
US20110224785A1 (en) | 2010-03-10 | 2011-09-15 | Hacohen Gil | Prosthetic mitral valve with tissue anchors |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
JP2013526388A (ja) | 2010-05-25 | 2013-06-24 | イエナバルブ テクノロジー インク | 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ |
CA2803149C (en) | 2010-06-21 | 2018-08-14 | Impala, Inc. | Replacement heart valve |
CN103189015B (zh) | 2010-07-09 | 2016-07-06 | 海莱夫简易股份公司 | 经导管的房室瓣假体 |
US9763657B2 (en) | 2010-07-21 | 2017-09-19 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US8992604B2 (en) | 2010-07-21 | 2015-03-31 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US9132009B2 (en) | 2010-07-21 | 2015-09-15 | Mitraltech Ltd. | Guide wires with commissural anchors to advance a prosthetic valve |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
EP2608741A2 (en) | 2010-08-24 | 2013-07-03 | St. Jude Medical, Inc. | Staged deployment devices and methods for transcatheter heart valve delivery systems |
US9039759B2 (en) | 2010-08-24 | 2015-05-26 | St. Jude Medical, Cardiology Division, Inc. | Repositioning of prosthetic heart valve and deployment |
AU2011302640B2 (en) | 2010-09-17 | 2014-11-06 | St. Jude Medical, Cardiology Division, Inc. | Staged deployment devices and methods for transcatheter heart valve delivery |
JP2013540484A (ja) | 2010-09-20 | 2013-11-07 | セント・ジュード・メディカル,カーディオロジー・ディヴィジョン,インコーポレイテッド | 折畳み可能な人工弁における弁尖の取付装置 |
EP2618784B1 (en) | 2010-09-23 | 2016-05-25 | Edwards Lifesciences CardiAQ LLC | Replacement heart valves and delivery devices |
US20120116496A1 (en) | 2010-11-05 | 2012-05-10 | Chuter Timothy A | Stent structures for use with valve replacements |
WO2012087842A1 (en) | 2010-12-23 | 2012-06-28 | The Foundry, Llc | System for mitral valve repair and replacement |
US8932343B2 (en) * | 2011-02-01 | 2015-01-13 | St. Jude Medical, Cardiology Division, Inc. | Blunt ended stent for prosthetic heart valve |
US9717593B2 (en) | 2011-02-01 | 2017-08-01 | St. Jude Medical, Cardiology Division, Inc. | Leaflet suturing to commissure points for prosthetic heart valve |
US9526638B2 (en) | 2011-02-03 | 2016-12-27 | Endospan Ltd. | Implantable medical devices constructed of shape memory material |
WO2012111006A1 (en) | 2011-02-17 | 2012-08-23 | Endospan Ltd. | Vascular bands and delivery systems therefor |
US9486341B2 (en) | 2011-03-02 | 2016-11-08 | Endospan Ltd. | Reduced-strain extra-vascular ring for treating aortic aneurysm |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) * | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9402721B2 (en) | 2011-06-01 | 2016-08-02 | Valcare, Inc. | Percutaneous transcatheter repair of heart valves via trans-apical access |
US8574287B2 (en) | 2011-06-14 | 2013-11-05 | Endospan Ltd. | Stents incorporating a plurality of strain-distribution locations |
ES2568377T3 (es) | 2011-06-21 | 2016-04-28 | Endospan Ltd | Sistema endovascular con endoprótesis que solapan circunferencialmente |
JP5872692B2 (ja) | 2011-06-21 | 2016-03-01 | トゥエルヴ, インコーポレイテッド | 人工治療装置 |
US10792152B2 (en) | 2011-06-23 | 2020-10-06 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
US9918840B2 (en) | 2011-06-23 | 2018-03-20 | Valtech Cardio, Ltd. | Closed band for percutaneous annuloplasty |
EP2729095B1 (en) | 2011-07-07 | 2016-10-26 | Endospan Ltd. | Stent fixation with reduced plastic deformation |
US20140324164A1 (en) | 2011-08-05 | 2014-10-30 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US8852272B2 (en) | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
WO2013021375A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Percutaneous mitral valve replacement and sealing |
US9060860B2 (en) | 2011-08-18 | 2015-06-23 | St. Jude Medical, Cardiology Division, Inc. | Devices and methods for transcatheter heart valve delivery |
US9839510B2 (en) | 2011-08-28 | 2017-12-12 | Endospan Ltd. | Stent-grafts with post-deployment variable radial displacement |
US8956404B2 (en) | 2011-09-12 | 2015-02-17 | Highlife Sas | Transcatheter valve prosthesis |
US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
CA3090422C (en) | 2011-10-19 | 2023-08-01 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
AU2012325809B2 (en) | 2011-10-19 | 2016-01-21 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
CN104159543B (zh) | 2011-10-21 | 2016-10-12 | 耶拿阀门科技公司 | 用于将可扩张心脏瓣膜支架引入患者体内的导管系统 |
US9427339B2 (en) | 2011-10-30 | 2016-08-30 | Endospan Ltd. | Triple-collar stent-graft |
US8858623B2 (en) | 2011-11-04 | 2014-10-14 | Valtech Cardio, Ltd. | Implant having multiple rotational assemblies |
EP3656434B1 (en) | 2011-11-08 | 2021-10-20 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
US9597204B2 (en) | 2011-12-04 | 2017-03-21 | Endospan Ltd. | Branched stent-graft system |
CA3095260C (en) | 2012-01-31 | 2023-09-19 | Mitral Valve Technologies Sarl | Mitral valve docking devices, systems and methods |
US9180008B2 (en) | 2012-02-29 | 2015-11-10 | Valcare, Inc. | Methods, devices, and systems for percutaneously anchoring annuloplasty rings |
US9839519B2 (en) | 2012-02-29 | 2017-12-12 | Valcare, Inc. | Percutaneous annuloplasty system with anterior-posterior adjustment |
US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
ES2535295T3 (es) | 2012-03-23 | 2015-05-08 | Sorin Group Italia S.R.L. | Prótesis de válvula plegable |
US9066800B2 (en) * | 2012-03-28 | 2015-06-30 | Medtronic, Inc. | Dual valve prosthesis for transcatheter valve implantation |
US9011515B2 (en) | 2012-04-19 | 2015-04-21 | Caisson Interventional, LLC | Heart valve assembly systems and methods |
US9427315B2 (en) | 2012-04-19 | 2016-08-30 | Caisson Interventional, LLC | Valve replacement systems and methods |
ITTO20120372A1 (it) * | 2012-04-27 | 2013-10-28 | Marcio Scorsin | Protesi valvolare cardiaca monocuspide |
WO2013171730A1 (en) | 2012-05-15 | 2013-11-21 | Endospan Ltd. | Stent-graft with fixation elements that are radially confined for delivery |
JP6227632B2 (ja) | 2012-05-16 | 2017-11-08 | イェーナヴァルヴ テクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング | 拡張可能心臓代用弁を導入するためのカテーテル送達システムおよび心臓弁欠陥の治療のための医療デバイス |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
WO2014022124A1 (en) * | 2012-07-28 | 2014-02-06 | Tendyne Holdings, Inc. | Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly |
US10206775B2 (en) | 2012-08-13 | 2019-02-19 | Medtronic, Inc. | Heart valve prosthesis |
US9232995B2 (en) | 2013-01-08 | 2016-01-12 | Medtronic, Inc. | Valve prosthesis and method for delivery |
US9510946B2 (en) * | 2012-09-06 | 2016-12-06 | Edwards Lifesciences Corporation | Heart valve sealing devices |
WO2014052818A1 (en) | 2012-09-29 | 2014-04-03 | Mitralign, Inc. | Plication lock delivery system and method of use thereof |
WO2014064694A2 (en) | 2012-10-23 | 2014-05-01 | Valtech Cardio, Ltd. | Controlled steering functionality for implant-delivery tool |
US10376266B2 (en) | 2012-10-23 | 2019-08-13 | Valtech Cardio, Ltd. | Percutaneous tissue anchor techniques |
US9144663B2 (en) * | 2012-10-24 | 2015-09-29 | Medtronic, Inc. | Methods and devices for repairing and/or preventing paravalvular leakage post-implantation of a valve prosthesis |
US9023099B2 (en) | 2012-10-31 | 2015-05-05 | Medtronic Vascular Galway Limited | Prosthetic mitral valve and delivery method |
US8628571B1 (en) | 2012-11-13 | 2014-01-14 | Mitraltech Ltd. | Percutaneously-deliverable mechanical valve |
US9730793B2 (en) | 2012-12-06 | 2017-08-15 | Valtech Cardio, Ltd. | Techniques for guide-wire based advancement of a tool |
WO2014108895A2 (en) | 2013-01-08 | 2014-07-17 | Endospan Ltd. | Minimization of stent-graft migration during implantation |
EP2948103B1 (en) | 2013-01-24 | 2022-12-07 | Cardiovalve Ltd | Ventricularly-anchored prosthetic valves |
US9439763B2 (en) | 2013-02-04 | 2016-09-13 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US9456897B2 (en) | 2013-02-21 | 2016-10-04 | Medtronic, Inc. | Transcatheter valve prosthesis and a concurrently delivered sealing component |
EP2961351B1 (en) | 2013-02-26 | 2018-11-28 | Mitralign, Inc. | Devices for percutaneous tricuspid valve repair |
WO2014138482A1 (en) | 2013-03-07 | 2014-09-12 | Cedars-Sinai Medical Center | Method and apparatus for percutaneous delivery and deployment of a cardiovascular prosthesis |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
EP2967830B1 (en) | 2013-03-11 | 2017-11-01 | Endospan Ltd. | Multi-component stent-graft system for aortic dissections |
US10449333B2 (en) | 2013-03-14 | 2019-10-22 | Valtech Cardio, Ltd. | Guidewire feeder |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US9730791B2 (en) | 2013-03-14 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US20140277427A1 (en) | 2013-03-14 | 2014-09-18 | Cardiaq Valve Technologies, Inc. | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US9724195B2 (en) | 2013-03-15 | 2017-08-08 | Mitralign, Inc. | Translation catheters and systems |
EP3804646A1 (en) | 2013-03-15 | 2021-04-14 | Valcare, Inc. | Systems for delivery of annuloplasty rings |
US10463489B2 (en) | 2013-04-02 | 2019-11-05 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US11224510B2 (en) | 2013-04-02 | 2022-01-18 | Tendyne Holdings, Inc. | Prosthetic heart valve and systems and methods for delivering the same |
US10478293B2 (en) | 2013-04-04 | 2019-11-19 | Tendyne Holdings, Inc. | Retrieval and repositioning system for prosthetic heart valve |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US10111747B2 (en) | 2013-05-20 | 2018-10-30 | Twelve, Inc. | Implantable heart valve devices, mitral valve repair devices and associated systems and methods |
US10813751B2 (en) * | 2013-05-22 | 2020-10-27 | Valcare, Inc. | Transcatheter prosthetic valve for mitral or tricuspid valve replacement |
EP3003187B1 (en) | 2013-05-24 | 2023-11-08 | Valcare, Inc. | Heart and peripheral vascular valve replacement in conjunction with a support ring |
US11058417B2 (en) | 2013-06-28 | 2021-07-13 | Valcare, Inc. | Device, system, and method to secure an article to a tissue |
EP3019092B1 (en) | 2013-07-10 | 2022-08-31 | Medtronic Inc. | Helical coil mitral valve annuloplasty systems |
US10524904B2 (en) * | 2013-07-11 | 2020-01-07 | Medtronic, Inc. | Valve positioning device |
WO2015023862A2 (en) | 2013-08-14 | 2015-02-19 | Mitral Valve Technologies Sa | Replacement heart valve apparatus and methods |
JP6563394B2 (ja) * | 2013-08-30 | 2019-08-21 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 人工弁のための径方向に折り畳み自在のフレーム及び当該フレームを製造するための方法 |
US10070857B2 (en) | 2013-08-31 | 2018-09-11 | Mitralign, Inc. | Devices and methods for locating and implanting tissue anchors at mitral valve commissure |
DE102013219781A1 (de) | 2013-09-30 | 2015-04-02 | Carl Zeiss Ag | Messanordnung und Verfahren zur Messung einer Schichtdicke |
US9839511B2 (en) | 2013-10-05 | 2017-12-12 | Sino Medical Sciences Technology Inc. | Device and method for mitral valve regurgitation treatment |
US9393111B2 (en) | 2014-01-15 | 2016-07-19 | Sino Medical Sciences Technology Inc. | Device and method for mitral valve regurgitation treatment |
WO2015052570A1 (en) | 2013-10-07 | 2015-04-16 | Medizinische Universität Wien | Implant and method for improving coaptation of an atrioventricular valve |
US10299793B2 (en) | 2013-10-23 | 2019-05-28 | Valtech Cardio, Ltd. | Anchor magazine |
US9662202B2 (en) | 2013-10-24 | 2017-05-30 | Medtronic, Inc. | Heart valve prosthesis |
JP6554094B2 (ja) * | 2013-10-28 | 2019-07-31 | テンダイン ホールディングス,インコーポレイテッド | 人工心臓弁及び人工心臓弁を送達するシステム及び方法 |
US9549818B2 (en) | 2013-11-12 | 2017-01-24 | St. Jude Medical, Cardiology Division, Inc. | Pneumatically power-assisted tavi delivery system |
WO2015075708A1 (en) | 2013-11-19 | 2015-05-28 | Endospan Ltd. | Stent system with radial-expansion locking |
US9622863B2 (en) * | 2013-11-22 | 2017-04-18 | Edwards Lifesciences Corporation | Aortic insufficiency repair device and method |
DE102013019890A1 (de) * | 2013-11-28 | 2015-05-28 | Bentley Innomed Gmbh | Medizinisches Implantat |
US9610162B2 (en) | 2013-12-26 | 2017-04-04 | Valtech Cardio, Ltd. | Implantation of flexible implant |
JP7126807B2 (ja) | 2014-02-04 | 2022-08-29 | インノブハート エッセ.エッレ.エッレ. | 心弁用人工器官 |
CA3205860A1 (en) | 2014-02-20 | 2015-08-27 | Mitral Valve Technologies Sarl | Coiled anchor for supporting prosthetic heart valve, prosthetic heart valve, and deployment device |
CR20160366A (es) | 2014-02-21 | 2016-11-15 | Mitral Valve Tecnhnologies Sarl | Dispositivos, sistemas y métodos de suministro de válvula mitral prostética y dispositivo de anclaje |
US10004599B2 (en) | 2014-02-21 | 2018-06-26 | Edwards Lifesciences Cardiaq Llc | Prosthesis, delivery device and methods of use |
USD755384S1 (en) | 2014-03-05 | 2016-05-03 | Edwards Lifesciences Cardiaq Llc | Stent |
EP2918248A1 (en) * | 2014-03-11 | 2015-09-16 | Epygon Sasu | An expandable stent-valve and a delivery device |
US20170014115A1 (en) | 2014-03-27 | 2017-01-19 | Transmural Systems Llc | Devices and methods for closure of transvascular or transcameral access ports |
WO2017185082A1 (en) * | 2016-04-23 | 2017-10-26 | Nasser Rafiee | Devices and methods for closure of transvascular or transcameral access ports |
CA2948379C (en) | 2014-05-19 | 2022-08-09 | J. Brent Ratz | Replacement mitral valve with annular flap |
US9532870B2 (en) | 2014-06-06 | 2017-01-03 | Edwards Lifesciences Corporation | Prosthetic valve for replacing a mitral valve |
EP2954875B1 (en) | 2014-06-10 | 2017-11-15 | St. Jude Medical, Cardiology Division, Inc. | Stent cell bridge for cuff attachment |
US9974647B2 (en) | 2014-06-12 | 2018-05-22 | Caisson Interventional, LLC | Two stage anchor and mitral valve assembly |
US10195026B2 (en) | 2014-07-22 | 2019-02-05 | Edwards Lifesciences Corporation | Mitral valve anchoring |
EP3174502B1 (en) | 2014-07-30 | 2022-04-06 | Cardiovalve Ltd | Apparatus for implantation of an articulatable prosthetic valve |
US10058424B2 (en) | 2014-08-21 | 2018-08-28 | Edwards Lifesciences Corporation | Dual-flange prosthetic valve frame |
US10016272B2 (en) | 2014-09-12 | 2018-07-10 | Mitral Valve Technologies Sarl | Mitral repair and replacement devices and methods |
US10195030B2 (en) | 2014-10-14 | 2019-02-05 | Valtech Cardio, Ltd. | Leaflet-restraining techniques |
US20160120643A1 (en) * | 2014-11-05 | 2016-05-05 | Tara Kupumbati | Transcatheter cardiac valve prosthetic |
US10758265B2 (en) | 2014-11-14 | 2020-09-01 | Cedars-Sinai Medical Center | Cardiovascular access and device delivery system |
US11173031B2 (en) | 2014-11-17 | 2021-11-16 | Mitrassist Medical Ltd. | Assistive device for a cardiac valve |
US10709820B2 (en) | 2014-11-24 | 2020-07-14 | Biotronik Ag | Method for producing a storable molded body made of bacterial cellulose |
WO2016098113A1 (en) | 2014-12-18 | 2016-06-23 | Endospan Ltd. | Endovascular stent-graft with fatigue-resistant lateral tube |
US9974651B2 (en) | 2015-02-05 | 2018-05-22 | Mitral Tech Ltd. | Prosthetic valve with axially-sliding frames |
EP3253333B1 (en) | 2015-02-05 | 2024-04-03 | Cardiovalve Ltd | Prosthetic valve with axially-sliding frames |
US20160256269A1 (en) | 2015-03-05 | 2016-09-08 | Mitralign, Inc. | Devices for treating paravalvular leakage and methods use thereof |
US10010417B2 (en) | 2015-04-16 | 2018-07-03 | Edwards Lifesciences Corporation | Low-profile prosthetic heart valve for replacing a mitral valve |
US10064718B2 (en) | 2015-04-16 | 2018-09-04 | Edwards Lifesciences Corporation | Low-profile prosthetic heart valve for replacing a mitral valve |
US10441416B2 (en) | 2015-04-21 | 2019-10-15 | Edwards Lifesciences Corporation | Percutaneous mitral valve replacement device |
CN114515173A (zh) | 2015-04-30 | 2022-05-20 | 瓦尔泰克卡迪欧有限公司 | 瓣膜成形术技术 |
US10376363B2 (en) | 2015-04-30 | 2019-08-13 | Edwards Lifesciences Cardiaq Llc | Replacement mitral valve, delivery system for replacement mitral valve and methods of use |
US10709555B2 (en) | 2015-05-01 | 2020-07-14 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
EP3100701A1 (en) | 2015-06-04 | 2016-12-07 | Epygon Sasu | Mitral valve stent with anterior native leaflet grasping and holding mechanism |
ES2742204T5 (es) | 2015-06-04 | 2023-10-05 | Epygon | Estent de válvula auriculoventricular con mecanismo de agarre y sujeción de valva nativa |
GB2539444A (en) | 2015-06-16 | 2016-12-21 | Ucl Business Plc | Prosthetic heart valve |
WO2016209970A1 (en) | 2015-06-22 | 2016-12-29 | Edwards Lifescience Cardiaq Llc | Actively controllable heart valve implant and methods of controlling same |
US10092400B2 (en) | 2015-06-23 | 2018-10-09 | Edwards Lifesciences Cardiaq Llc | Systems and methods for anchoring and sealing a prosthetic heart valve |
US10238490B2 (en) | 2015-08-21 | 2019-03-26 | Twelve, Inc. | Implant heart valve devices, mitral valve repair devices and associated systems and methods |
US10117744B2 (en) | 2015-08-26 | 2018-11-06 | Edwards Lifesciences Cardiaq Llc | Replacement heart valves and methods of delivery |
US10575951B2 (en) | 2015-08-26 | 2020-03-03 | Edwards Lifesciences Cardiaq Llc | Delivery device and methods of use for transapical delivery of replacement mitral valve |
US10350066B2 (en) | 2015-08-28 | 2019-07-16 | Edwards Lifesciences Cardiaq Llc | Steerable delivery system for replacement mitral valve and methods of use |
US10531956B2 (en) | 2015-09-03 | 2020-01-14 | Vesalous Cardiovascular Inc. | Apparatus for repairing heart valves and method of use thereof |
US10456243B2 (en) | 2015-10-09 | 2019-10-29 | Medtronic Vascular, Inc. | Heart valves prostheses and methods for percutaneous heart valve replacement |
US10470876B2 (en) | 2015-11-10 | 2019-11-12 | Edwards Lifesciences Corporation | Transcatheter heart valve for replacing natural mitral valve |
US10376364B2 (en) | 2015-11-10 | 2019-08-13 | Edwards Lifesciences Corporation | Implant delivery capsule |
US10751182B2 (en) | 2015-12-30 | 2020-08-25 | Edwards Lifesciences Corporation | System and method for reshaping right heart |
WO2017117370A2 (en) | 2015-12-30 | 2017-07-06 | Mitralign, Inc. | System and method for reducing tricuspid regurgitation |
WO2017117388A1 (en) | 2015-12-30 | 2017-07-06 | Caisson Interventional, LLC | Systems and methods for heart valve therapy |
US10426619B2 (en) | 2015-12-30 | 2019-10-01 | Avvie Gmbh | Implant and method for improving coaptation of an atrioventricular valve |
US10092398B2 (en) | 2016-01-07 | 2018-10-09 | Medtronic Vascular, Inc. | Prosthetic heart valve cooling |
US10321992B2 (en) | 2016-02-01 | 2019-06-18 | Medtronic, Inc. | Heart valve prostheses having multiple support arms and methods for percutaneous heart valve replacement |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
USD815744S1 (en) | 2016-04-28 | 2018-04-17 | Edwards Lifesciences Cardiaq Llc | Valve frame for a delivery system |
CN116172753A (zh) * | 2016-04-29 | 2023-05-30 | 美敦力瓦斯科尔勒公司 | 具有带系绳的锚定件的假体心脏瓣膜设备以及相关联的系统和方法 |
EP3454795B1 (en) | 2016-05-13 | 2023-01-11 | JenaValve Technology, Inc. | Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system |
US10702274B2 (en) | 2016-05-26 | 2020-07-07 | Edwards Lifesciences Corporation | Method and system for closing left atrial appendage |
US20170360558A1 (en) * | 2016-06-16 | 2017-12-21 | Jianlu Ma | Method and design for a mitral regurgitation treatment device |
GB201611910D0 (en) | 2016-07-08 | 2016-08-24 | Valtech Cardio Ltd | Adjustable annuloplasty device with alternating peaks and troughs |
US10350062B2 (en) | 2016-07-21 | 2019-07-16 | Edwards Lifesciences Corporation | Replacement heart valve prosthesis |
WO2018029680A1 (en) | 2016-08-10 | 2018-02-15 | Mitraltech Ltd. | Prosthetic valve with concentric frames |
USD800908S1 (en) | 2016-08-10 | 2017-10-24 | Mitraltech Ltd. | Prosthetic valve element |
US10828152B2 (en) | 2016-08-11 | 2020-11-10 | 4C Medical Technologies, Inc. | Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function |
CN107753153B (zh) | 2016-08-15 | 2022-05-31 | 沃卡尔有限公司 | 用于治疗心脏瓣膜关闭不全的装置和方法 |
EP3500214A4 (en) | 2016-08-19 | 2019-07-24 | Edwards Lifesciences Corporation | MANUFACTURED POSITION SYSTEM FOR MITRAL REPLACEMENT VALVE AND METHODS OF USE |
WO2018039631A1 (en) | 2016-08-26 | 2018-03-01 | Edwards Lifesciences Corporation | Multi-portion replacement heat valve prosthesis |
US10575946B2 (en) | 2016-09-01 | 2020-03-03 | Medtronic Vascular, Inc. | Heart valve prosthesis and separate support flange for attachment thereto |
US10357361B2 (en) * | 2016-09-15 | 2019-07-23 | Edwards Lifesciences Corporation | Heart valve pinch devices and delivery systems |
US11241307B2 (en) | 2016-10-13 | 2022-02-08 | Boston Scientific Scimed, Inc. | Replacement heart valve with diaphragm |
US10758348B2 (en) | 2016-11-02 | 2020-09-01 | Edwards Lifesciences Corporation | Supra and sub-annular mitral valve delivery system |
US10456247B2 (en) | 2016-11-04 | 2019-10-29 | Highlife Sas | Transcatheter valve prosthesis |
US11376121B2 (en) | 2016-11-04 | 2022-07-05 | Highlife Sas | Transcatheter valve prosthesis |
US10195027B2 (en) * | 2016-11-04 | 2019-02-05 | Highlife Sas | Transcatheter valve prosthesis |
US9999502B2 (en) | 2016-11-04 | 2018-06-19 | Highlife Sas | Transcather valve prosthesis |
US10188514B2 (en) | 2016-11-04 | 2019-01-29 | Highlife Sas | Transcatheter valve prosthesis |
US10493248B2 (en) | 2016-11-09 | 2019-12-03 | Medtronic Vascular, Inc. | Chordae tendineae management devices for use with a valve prosthesis delivery system and methods of use thereof |
US10368988B2 (en) | 2016-11-09 | 2019-08-06 | Medtronic Vascular, Inc. | Valve delivery system having an integral displacement component for managing chordae tendineae in situ and methods of use thereof |
EP3547964A1 (en) | 2016-12-02 | 2019-10-09 | St. Jude Medical, Cardiology Division, Inc. | Transcatheter delivery system with transverse wheel actuation |
US10758352B2 (en) | 2016-12-02 | 2020-09-01 | St. Jude Medical, Cardiology Division, Inc. | Transcatheter delivery system with two modes of actuation |
US20190358033A1 (en) * | 2017-01-11 | 2019-11-28 | Mitrassist Medical Ltd. | Heart valve prosthesis |
US10561495B2 (en) | 2017-01-24 | 2020-02-18 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
JP7094965B2 (ja) | 2017-01-27 | 2022-07-04 | イエナバルブ テクノロジー インク | 心臓弁模倣 |
EP3372198B1 (en) | 2017-03-06 | 2019-06-19 | AVVie GmbH | Implant for improving coaptation of an atrioventricular valve |
CN108618871A (zh) | 2017-03-17 | 2018-10-09 | 沃卡尔有限公司 | 具有多方向锚部的二尖瓣或三尖瓣修复系统 |
US10716668B2 (en) | 2017-04-05 | 2020-07-21 | Medtronic, Inc. | Delivery system with anchoring nosecone and method of delivery |
US11045627B2 (en) | 2017-04-18 | 2021-06-29 | Edwards Lifesciences Corporation | Catheter system with linear actuation control mechanism |
US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
US20180303488A1 (en) | 2017-04-20 | 2018-10-25 | Medtronic, Inc. | Stabilization of a transseptal delivery device |
US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
EP3624739A1 (en) | 2017-05-15 | 2020-03-25 | St. Jude Medical, Cardiology Division, Inc. | Transcatheter delivery system with wheel actuation |
US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
US10813757B2 (en) | 2017-07-06 | 2020-10-27 | Edwards Lifesciences Corporation | Steerable rail delivery system |
US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
US11666444B2 (en) * | 2017-08-03 | 2023-06-06 | The Regents Of The University Of California | Atrial cage for placement, securing and anchoring of atrioventricular valves |
US10888421B2 (en) | 2017-09-19 | 2021-01-12 | Cardiovalve Ltd. | Prosthetic heart valve with pouch |
US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
US10575948B2 (en) | 2017-08-03 | 2020-03-03 | Cardiovalve Ltd. | Prosthetic heart valve |
US10537426B2 (en) | 2017-08-03 | 2020-01-21 | Cardiovalve Ltd. | Prosthetic heart valve |
US11246704B2 (en) | 2017-08-03 | 2022-02-15 | Cardiovalve Ltd. | Prosthetic heart valve |
WO2019040781A1 (en) | 2017-08-24 | 2019-02-28 | Medtronic Vascular, Inc. | TRANS-SEPTAL DELIVERY SYSTEM HAVING A DEVIATION SEGMENT AND METHODS OF USE |
CN111263622A (zh) | 2017-08-25 | 2020-06-09 | 内奥瓦斯克迪亚拉公司 | 顺序展开的经导管二尖瓣假体 |
US11071846B2 (en) | 2017-09-14 | 2021-07-27 | Medtronic Vascular, Inc. | Deflection catheter for aiding in bending of a catheter |
US10881511B2 (en) | 2017-09-19 | 2021-01-05 | Cardiovalve Ltd. | Prosthetic valve with tissue anchors configured to exert opposing clamping forces on native valve tissue |
US9895226B1 (en) | 2017-10-19 | 2018-02-20 | Mitral Tech Ltd. | Techniques for use with prosthetic valve leaflets |
US10835221B2 (en) | 2017-11-02 | 2020-11-17 | Valtech Cardio, Ltd. | Implant-cinching devices and systems |
US10806574B2 (en) | 2017-11-20 | 2020-10-20 | Medtronic Vascular, Inc. | Delivery systems having a temporary valve and methods of use |
US11135062B2 (en) | 2017-11-20 | 2021-10-05 | Valtech Cardio Ltd. | Cinching of dilated heart muscle |
GB201720803D0 (en) | 2017-12-13 | 2018-01-24 | Mitraltech Ltd | Prosthetic Valve and delivery tool therefor |
CN109966023A (zh) | 2017-12-28 | 2019-07-05 | 上海微创心通医疗科技有限公司 | 心脏瓣膜假体及其支架 |
WO2019136378A1 (en) | 2018-01-05 | 2019-07-11 | Mitrx, Inc. | Pursestring suture retractor and method of use |
GB201800399D0 (en) | 2018-01-10 | 2018-02-21 | Mitraltech Ltd | Temperature-control during crimping of an implant |
CN111655200B (zh) | 2018-01-24 | 2023-07-14 | 爱德华兹生命科学创新(以色列)有限公司 | 瓣环成形术结构的收缩 |
WO2019147846A2 (en) | 2018-01-25 | 2019-08-01 | Edwards Lifesciences Corporation | Delivery system for aided replacement valve recapture and repositioning post- deployment |
WO2019145941A1 (en) | 2018-01-26 | 2019-08-01 | Valtech Cardio, Ltd. | Techniques for facilitating heart valve tethering and chord replacement |
WO2019165213A1 (en) | 2018-02-22 | 2019-08-29 | Medtronic Vascular, Inc. | Prosthetic heart valve delivery systems and methods |
US11051934B2 (en) | 2018-02-28 | 2021-07-06 | Edwards Lifesciences Corporation | Prosthetic mitral valve with improved anchors and seal |
CA3106104A1 (en) | 2018-07-12 | 2020-01-16 | Valtech Cardio, Ltd. | Annuloplasty systems and locking tools therefor |
US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
EP3620133A1 (en) | 2018-09-07 | 2020-03-11 | AVVie GmbH | Implant for improving coaptation of an artrioventricular valve |
US10779946B2 (en) | 2018-09-17 | 2020-09-22 | Cardiovalve Ltd. | Leaflet-testing apparatus |
EP3876870B1 (en) | 2018-11-08 | 2023-12-20 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
WO2020117842A1 (en) | 2018-12-03 | 2020-06-11 | Valcare, Inc. | Stabilizing and adjusting tool for controlling a minimally invasive mitral / tricuspid valve repair system |
JP7403547B2 (ja) | 2019-01-23 | 2023-12-22 | ニオバスク メディカル リミテッド | 被覆された流動修正装置 |
US11612482B2 (en) | 2019-03-06 | 2023-03-28 | Medtronic, Inc. | Trans-septal delivery system and methods of use |
RU2722797C1 (ru) * | 2019-03-19 | 2020-06-03 | Александр Васильевич Самков | Искусственный клапан сердца |
JP7438236B2 (ja) | 2019-04-01 | 2024-02-26 | ニオバスク ティアラ インコーポレイテッド | 制御可能に展開可能な補綴弁 |
AU2020279750B2 (en) | 2019-05-20 | 2023-07-13 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
AU2020295566B2 (en) | 2019-06-20 | 2023-07-20 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
CN114173713A (zh) | 2019-07-15 | 2022-03-11 | 沃卡尔有限公司 | 经导管生物假体构件和支撑结构 |
CN114786621A (zh) | 2019-10-29 | 2022-07-22 | 爱德华兹生命科学创新(以色列)有限公司 | 瓣环成形术和组织锚固技术 |
US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
WO2022156335A1 (zh) * | 2021-01-20 | 2022-07-28 | 上海纽脉医疗科技股份有限公司 | 一种介入式人工心脏瓣膜及医用装置 |
DE102021000811A1 (de) * | 2021-02-10 | 2022-08-11 | Devie Medical Gmbh | Wirkstofffreisetzende Herzklappenprothese, welche infizierte Gewebestrukturen im Herzen kompartimentiert oder einer postoperativen Infektion vorbeugt |
WO2022266022A1 (en) * | 2021-06-15 | 2022-12-22 | Cedars-Sinai Medical Center | Heart valve repair prostheses, delivery devices and methods |
WO2023012680A1 (en) * | 2021-08-04 | 2023-02-09 | Laguna Tech Usa, Inc. | Prosthetic heart valve device, frame, delivery system, interventional system and related methods |
WO2023164749A1 (en) * | 2022-03-03 | 2023-09-07 | Hugh Paterson | Device and method for augmenting mitral valve function |
CN115192256A (zh) * | 2022-06-24 | 2022-10-18 | 宁波健世科技股份有限公司 | 一种便于捕捉瓣叶的瓣膜假体 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060058872A1 (en) * | 2003-12-23 | 2006-03-16 | Amr Salahieh | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
US20080071361A1 (en) * | 2006-09-19 | 2008-03-20 | Yosi Tuval | Leaflet-sensitive valve fixation member |
CN101180010A (zh) * | 2005-05-24 | 2008-05-14 | 爱德华兹生命科学公司 | 快速展开假体心脏瓣膜 |
WO2009053497A1 (en) * | 2007-10-25 | 2009-04-30 | Symetis Sa | Stents, valved-stents and methods and systems for delivery thereof |
WO2009132187A1 (en) * | 2008-04-23 | 2009-10-29 | Medtronic, Inc. | Stented heart valve devices |
Family Cites Families (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US307743A (en) | 1884-11-11 | Theeoist boabdmaf | ||
US6050936A (en) * | 1997-01-02 | 2000-04-18 | Myocor, Inc. | Heart wall tension reduction apparatus |
US6071292A (en) * | 1997-06-28 | 2000-06-06 | Transvascular, Inc. | Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures |
WO1999011201A2 (en) * | 1997-09-04 | 1999-03-11 | Endocore, Inc. | Artificial chordae replacement |
US6332893B1 (en) | 1997-12-17 | 2001-12-25 | Myocor, Inc. | Valve to myocardium tension members device and method |
US6425916B1 (en) * | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
SE514718C2 (sv) * | 1999-06-29 | 2001-04-09 | Jan Otto Solem | Anordning för behandling av bristande tillslutningsförmåga hos mitralisklaffapparaten |
US6997951B2 (en) * | 1999-06-30 | 2006-02-14 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US7192442B2 (en) * | 1999-06-30 | 2007-03-20 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6926730B1 (en) | 2000-10-10 | 2005-08-09 | Medtronic, Inc. | Minimally invasive valve repair procedure and apparatus |
US7296577B2 (en) * | 2000-01-31 | 2007-11-20 | Edwards Lifescience Ag | Transluminal mitral annuloplasty with active anchoring |
US6989028B2 (en) * | 2000-01-31 | 2006-01-24 | Edwards Lifesciences Ag | Medical system and method for remodeling an extravascular tissue structure |
DE10010074B4 (de) * | 2000-02-28 | 2005-04-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen |
US6676698B2 (en) * | 2000-06-26 | 2004-01-13 | Rex Medicol, L.P. | Vascular device with valve for approximating vessel wall |
US6602288B1 (en) * | 2000-10-05 | 2003-08-05 | Edwards Lifesciences Corporation | Minimally-invasive annuloplasty repair segment delivery template, system and method of use |
US6723038B1 (en) * | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
US7037334B1 (en) * | 2001-04-24 | 2006-05-02 | Mitralign, Inc. | Method and apparatus for catheter-based annuloplasty using local plications |
FR2828263B1 (fr) * | 2001-08-03 | 2007-05-11 | Philipp Bonhoeffer | Dispositif d'implantation d'un implant et procede d'implantation du dispositif |
US20060052821A1 (en) | 2001-09-06 | 2006-03-09 | Ovalis, Inc. | Systems and methods for treating septal defects |
US20050267495A1 (en) | 2004-05-17 | 2005-12-01 | Gateway Medical, Inc. | Systems and methods for closing internal tissue defects |
US6702835B2 (en) * | 2001-09-07 | 2004-03-09 | Core Medical, Inc. | Needle apparatus for closing septal defects and methods for using such apparatus |
US6776784B2 (en) * | 2001-09-06 | 2004-08-17 | Core Medical, Inc. | Clip apparatus for closing septal defects and methods of use |
US20050177180A1 (en) * | 2001-11-28 | 2005-08-11 | Aptus Endosystems, Inc. | Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ |
AU2003210510A1 (en) | 2002-01-14 | 2003-07-30 | Nmt Medical, Inc. | Patent foramen ovale (pfo) closure method and device |
US7588582B2 (en) | 2002-06-13 | 2009-09-15 | Guided Delivery Systems Inc. | Methods for remodeling cardiac tissue |
EP1530441B1 (en) | 2002-06-13 | 2017-08-02 | Ancora Heart, Inc. | Devices and methods for heart valve repair |
US8641727B2 (en) * | 2002-06-13 | 2014-02-04 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US7753924B2 (en) | 2003-09-04 | 2010-07-13 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US20040243227A1 (en) * | 2002-06-13 | 2004-12-02 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US8287555B2 (en) * | 2003-02-06 | 2012-10-16 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US7758637B2 (en) | 2003-02-06 | 2010-07-20 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US7753922B2 (en) * | 2003-09-04 | 2010-07-13 | Guided Delivery Systems, Inc. | Devices and methods for cardiac annulus stabilization and treatment |
US7666193B2 (en) * | 2002-06-13 | 2010-02-23 | Guided Delivery Sytems, Inc. | Delivery devices and methods for heart valve repair |
AU2003265354A1 (en) * | 2002-08-01 | 2004-02-23 | The General Hospital Corporation | Cardiac devices and methods for minimally invasive repair of ischemic mitral regurgitation |
DE10362367B3 (de) | 2002-08-13 | 2022-02-24 | Jenavalve Technology Inc. | Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen |
CA2714875C (en) * | 2002-08-28 | 2014-01-07 | Heart Leaflet Technologies, Inc. | Method and device for treating diseased valve |
US8066724B2 (en) | 2002-09-12 | 2011-11-29 | Medtronic, Inc. | Anastomosis apparatus and methods |
US6997950B2 (en) | 2003-01-16 | 2006-02-14 | Chawla Surendra K | Valve repair device |
WO2004069055A2 (en) | 2003-02-04 | 2004-08-19 | Ev3 Sunnyvale Inc. | Patent foramen ovale closure system |
US7201772B2 (en) * | 2003-07-08 | 2007-04-10 | Ventor Technologies, Ltd. | Fluid flow prosthetic device |
US7534204B2 (en) * | 2003-09-03 | 2009-05-19 | Guided Delivery Systems, Inc. | Cardiac visualization devices and methods |
WO2005027797A1 (en) | 2003-09-23 | 2005-03-31 | Ersin Erek | A mitral web apparatus for mitral valve insufficiencies |
EG24012A (en) * | 2003-09-24 | 2008-03-23 | Wael Mohamed Nabil Lotfy | Valved balloon stent |
US20050273138A1 (en) | 2003-12-19 | 2005-12-08 | Guided Delivery Systems, Inc. | Devices and methods for anchoring tissue |
US7431726B2 (en) | 2003-12-23 | 2008-10-07 | Mitralign, Inc. | Tissue fastening systems and methods utilizing magnetic guidance |
EP2526895B1 (en) * | 2003-12-23 | 2014-01-29 | Sadra Medical, Inc. | Repositionable heart valve |
US8864822B2 (en) * | 2003-12-23 | 2014-10-21 | Mitralign, Inc. | Devices and methods for introducing elements into tissue |
US20050187568A1 (en) * | 2004-02-20 | 2005-08-25 | Klenk Alan R. | Devices and methods for closing a patent foramen ovale with a coil-shaped closure device |
US8206439B2 (en) * | 2004-02-23 | 2012-06-26 | International Heart Institute Of Montana Foundation | Internal prosthesis for reconstruction of cardiac geometry |
US20060052867A1 (en) * | 2004-09-07 | 2006-03-09 | Medtronic, Inc | Replacement prosthetic heart valve, system and method of implant |
US7704277B2 (en) * | 2004-09-14 | 2010-04-27 | Edwards Lifesciences Ag | Device and method for treatment of heart valve regurgitation |
US7211110B2 (en) | 2004-12-09 | 2007-05-01 | Edwards Lifesciences Corporation | Diagnostic kit to assist with heart valve annulus adjustment |
US20060259135A1 (en) * | 2005-04-20 | 2006-11-16 | The Cleveland Clinic Foundation | Apparatus and method for replacing a cardiac valve |
US8951285B2 (en) * | 2005-07-05 | 2015-02-10 | Mitralign, Inc. | Tissue anchor, anchoring system and methods of using the same |
WO2007013999A2 (en) * | 2005-07-21 | 2007-02-01 | Florida International University | Collapsible heart valve with polymer leaflets |
US20070055206A1 (en) * | 2005-08-10 | 2007-03-08 | Guided Delivery Systems, Inc. | Methods and devices for deployment of tissue anchors |
WO2007054015A1 (en) * | 2005-11-09 | 2007-05-18 | Ning Wen | An artificial heart valve stent and weaving method thereof |
AU2006315812B2 (en) * | 2005-11-10 | 2013-03-28 | Cardiaq Valve Technologies, Inc. | Balloon-expandable, self-expanding, vascular prosthesis connecting stent |
EP1991168B1 (en) * | 2006-02-16 | 2016-01-27 | Transcatheter Technologies GmbH | Minimally invasive heart valve replacement |
US7635386B1 (en) | 2006-03-07 | 2009-12-22 | University Of Maryland, Baltimore | Methods and devices for performing cardiac valve repair |
US7431692B2 (en) | 2006-03-09 | 2008-10-07 | Edwards Lifesciences Corporation | Apparatus, system, and method for applying and adjusting a tensioning element to a hollow body organ |
US7691151B2 (en) * | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
EP1849440A1 (en) * | 2006-04-28 | 2007-10-31 | Younes Boudjemline | Vascular stents with varying diameter |
US8257429B2 (en) * | 2006-08-21 | 2012-09-04 | Oregon Health & Science University | Biomedical valve devices, support frames for use in such devices, and related methods |
FR2906454B1 (fr) * | 2006-09-28 | 2009-04-10 | Perouse Soc Par Actions Simpli | Implant destine a etre place dans un conduit de circulation du sang. |
US20110257723A1 (en) * | 2006-11-07 | 2011-10-20 | Dc Devices, Inc. | Devices and methods for coronary sinus pressure relief |
US9510943B2 (en) * | 2007-01-19 | 2016-12-06 | Medtronic, Inc. | Stented heart valve devices and methods for atrioventricular valve replacement |
CA2677648C (en) * | 2007-02-16 | 2015-10-27 | Medtronic, Inc. | Replacement prosthetic heart valves and methods of implantation |
US20080208328A1 (en) * | 2007-02-23 | 2008-08-28 | Endovalve, Inc. | Systems and Methods For Placement of Valve Prosthesis System |
US8845723B2 (en) * | 2007-03-13 | 2014-09-30 | Mitralign, Inc. | Systems and methods for introducing elements into tissue |
US9138315B2 (en) | 2007-04-13 | 2015-09-22 | Jenavalve Technology Gmbh | Medical device for treating a heart valve insufficiency or stenosis |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
FR2915087B1 (fr) | 2007-04-20 | 2021-11-26 | Corevalve Inc | Implant de traitement d'une valve cardiaque, en particulier d'une valve mitrale, materiel inculant cet implant et materiel de mise en place de cet implant. |
US8747458B2 (en) * | 2007-08-20 | 2014-06-10 | Medtronic Ventor Technologies Ltd. | Stent loading tool and method for use thereof |
US8834551B2 (en) * | 2007-08-31 | 2014-09-16 | Rex Medical, L.P. | Vascular device with valve for approximating vessel wall |
US9125632B2 (en) | 2007-10-19 | 2015-09-08 | Guided Delivery Systems, Inc. | Systems and methods for cardiac remodeling |
WO2009094188A2 (en) * | 2008-01-24 | 2009-07-30 | Medtronic, Inc. | Stents for prosthetic heart valves |
CA2713934C (en) | 2008-02-06 | 2015-10-20 | Guided Delivery Systems, Inc. | Multi-window guide tunnel |
EP2259740A2 (en) | 2008-02-20 | 2010-12-15 | Guided Delivery Systems, Inc. | Electrophysiology catheter system |
US9168130B2 (en) * | 2008-02-26 | 2015-10-27 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
US8317858B2 (en) | 2008-02-26 | 2012-11-27 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
DK3967274T3 (da) | 2008-04-23 | 2022-10-03 | Medtronic Inc | Hjerteklapanordninger med stent |
US20090276040A1 (en) * | 2008-05-01 | 2009-11-05 | Edwards Lifesciences Corporation | Device and method for replacing mitral valve |
US20100023056A1 (en) * | 2008-07-23 | 2010-01-28 | Guided Delivery Systems Inc. | Tether-anchor assemblies |
US20100030330A1 (en) | 2008-08-01 | 2010-02-04 | Edwards Lifesciences Corporation | Device and method for mitral valve repair |
US8945211B2 (en) | 2008-09-12 | 2015-02-03 | Mitralign, Inc. | Tissue plication device and method for its use |
CN102438546B (zh) * | 2008-11-21 | 2015-07-15 | 经皮心血管解决方案公司 | 人工心脏瓣膜 |
US8308798B2 (en) * | 2008-12-19 | 2012-11-13 | Edwards Lifesciences Corporation | Quick-connect prosthetic heart valve and methods |
US8808368B2 (en) * | 2008-12-22 | 2014-08-19 | Valtech Cardio, Ltd. | Implantation of repair chords in the heart |
US20100217382A1 (en) * | 2009-02-25 | 2010-08-26 | Edwards Lifesciences | Mitral valve replacement with atrial anchoring |
EP2400924B1 (en) * | 2009-02-27 | 2017-06-28 | St. Jude Medical, Inc. | Prosthetic heart valve |
CN101919753A (zh) | 2009-03-30 | 2010-12-22 | 卡迪万蒂奇医药公司 | 人工主动脉瓣膜或二尖瓣膜的无缝合移植方法和装置 |
WO2010121076A2 (en) * | 2009-04-15 | 2010-10-21 | Cardiaq Valve Technologies, Inc. | Vascular implant and delivery system |
US8845722B2 (en) * | 2009-08-03 | 2014-09-30 | Shlomo Gabbay | Heart valve prosthesis and method of implantation thereof |
US8449599B2 (en) * | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
EP2509538B1 (en) * | 2009-12-08 | 2017-09-20 | Avalon Medical Ltd. | Device and system for transcatheter mitral valve replacement |
US10433956B2 (en) * | 2010-02-24 | 2019-10-08 | Medtronic Ventor Technologies Ltd. | Mitral prosthesis and methods for implantation |
US20110224785A1 (en) * | 2010-03-10 | 2011-09-15 | Hacohen Gil | Prosthetic mitral valve with tissue anchors |
US8623079B2 (en) * | 2010-04-23 | 2014-01-07 | Medtronic, Inc. | Stents for prosthetic heart valves |
US8579964B2 (en) * | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US8992604B2 (en) * | 2010-07-21 | 2015-03-31 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
EP2444030A1 (en) * | 2010-08-31 | 2012-04-25 | Biotronik AG | Medical valve implant for implantation in an animal body and/or human body |
US20120078360A1 (en) * | 2010-09-23 | 2012-03-29 | Nasser Rafiee | Prosthetic devices, systems and methods for replacing heart valves |
EP2618784B1 (en) * | 2010-09-23 | 2016-05-25 | Edwards Lifesciences CardiAQ LLC | Replacement heart valves and delivery devices |
US9579193B2 (en) * | 2010-09-23 | 2017-02-28 | Transmural Systems Llc | Methods and systems for delivering prostheses using rail techniques |
US9308087B2 (en) * | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) * | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US8852272B2 (en) * | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US9205236B2 (en) * | 2011-12-22 | 2015-12-08 | Corvia Medical, Inc. | Methods, systems, and devices for resizable intra-atrial shunts |
WO2013103612A1 (en) * | 2012-01-04 | 2013-07-11 | Tendyne Holdings, Inc. | Improved multi-component cuff designs for transcatheter mitral valve replacement, subvalvular sealing apparatus for transcatheter mitral valves and wire framed leaflet assembly |
US9345573B2 (en) * | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US8926690B2 (en) * | 2012-08-13 | 2015-01-06 | Medtronic, Inc. | Heart valve prosthesis |
US9510946B2 (en) * | 2012-09-06 | 2016-12-06 | Edwards Lifesciences Corporation | Heart valve sealing devices |
US9072602B2 (en) * | 2012-11-14 | 2015-07-07 | Medtronic, Inc. | Transcatheter valve prosthesis having a variable shaped cross-section for preventing paravalvular leakage |
US9066801B2 (en) * | 2013-01-08 | 2015-06-30 | Medtronic, Inc. | Valve prosthesis and method for delivery |
US9675451B2 (en) * | 2013-02-01 | 2017-06-13 | Medtronic CV Luxembourg S.a.r.l. | Anti-paravalvular leakage component for a transcatheter valve prosthesis |
US9439763B2 (en) * | 2013-02-04 | 2016-09-13 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US20140277427A1 (en) * | 2013-03-14 | 2014-09-18 | Cardiaq Valve Technologies, Inc. | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US9730791B2 (en) * | 2013-03-14 | 2017-08-15 | Edwards Lifesciences Cardiaq Llc | Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery |
US10456243B2 (en) * | 2015-10-09 | 2019-10-29 | Medtronic Vascular, Inc. | Heart valves prostheses and methods for percutaneous heart valve replacement |
US10321992B2 (en) * | 2016-02-01 | 2019-06-18 | Medtronic, Inc. | Heart valve prostheses having multiple support arms and methods for percutaneous heart valve replacement |
-
2010
- 2010-10-28 US US12/914,611 patent/US10433956B2/en active Active
- 2010-10-28 US US12/914,678 patent/US9072603B2/en active Active
-
2011
- 2011-02-24 WO PCT/US2011/026087 patent/WO2011106533A1/en active Application Filing
- 2011-02-24 EP EP11707291.8A patent/EP2538881B1/en active Active
- 2011-02-24 WO PCT/US2011/026101 patent/WO2011106544A1/en active Application Filing
- 2011-02-24 CN CN201180020522.2A patent/CN102985032B/zh active Active
- 2011-02-24 CN CN2011800205561A patent/CN103068341A/zh active Pending
- 2011-02-24 EP EP11707292.6A patent/EP2538882B1/en active Active
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2019
- 2019-10-04 US US16/592,804 patent/US20200030092A1/en not_active Abandoned
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2021
- 2021-12-27 US US17/562,351 patent/US20220117732A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060058872A1 (en) * | 2003-12-23 | 2006-03-16 | Amr Salahieh | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
CN101180010A (zh) * | 2005-05-24 | 2008-05-14 | 爱德华兹生命科学公司 | 快速展开假体心脏瓣膜 |
US20080071361A1 (en) * | 2006-09-19 | 2008-03-20 | Yosi Tuval | Leaflet-sensitive valve fixation member |
WO2009053497A1 (en) * | 2007-10-25 | 2009-04-30 | Symetis Sa | Stents, valved-stents and methods and systems for delivery thereof |
WO2009132187A1 (en) * | 2008-04-23 | 2009-10-29 | Medtronic, Inc. | Stented heart valve devices |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105744915A (zh) * | 2013-11-20 | 2016-07-06 | 詹姆斯·E·科尔曼 | 可调节的心脏瓣膜植入物 |
US9848880B2 (en) | 2013-11-20 | 2017-12-26 | James E. Coleman | Adjustable heart valve implant |
US10646226B2 (en) | 2013-11-20 | 2020-05-12 | James E. Coleman | Controlling a size of a pyloris |
US10799242B2 (en) | 2013-11-20 | 2020-10-13 | James E. Coleman | Adjustable heart valve implant |
CN105662651A (zh) * | 2014-12-05 | 2016-06-15 | Nvt股份公司 | 人工心脏瓣膜和用于其的输送系统 |
US11547558B2 (en) | 2016-10-24 | 2023-01-10 | Ningbo Jenscare Biotechnology Co., Ltd. | Heart valve prosthesis anchored to interventricular septum and conveying and releasing method thereof |
Also Published As
Publication number | Publication date |
---|---|
US20200030092A1 (en) | 2020-01-30 |
CN102985032A (zh) | 2013-03-20 |
EP2538882B1 (en) | 2022-11-09 |
WO2011106544A1 (en) | 2011-09-01 |
WO2011106533A9 (en) | 2011-12-08 |
US20220117732A1 (en) | 2022-04-21 |
EP2538882A1 (en) | 2013-01-02 |
US20110208298A1 (en) | 2011-08-25 |
EP2538881A1 (en) | 2013-01-02 |
CN102985032B (zh) | 2015-11-25 |
WO2011106533A1 (en) | 2011-09-01 |
US9072603B2 (en) | 2015-07-07 |
US10433956B2 (en) | 2019-10-08 |
US20110208297A1 (en) | 2011-08-25 |
EP2538881B1 (en) | 2022-11-30 |
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