CN103110976A - Skin antimicrobial gel recipe and preparation method thereof - Google Patents

Abstract

The invention discloses a skin antimicrobial gel recipe and a preparation method thereof. The gel comprises the raw materials of chitosan-iodine, glacial acetic acid, polysorbate-20, glycerin, potassium iodate, chitosan and purified water. The preparation method comprises the following steps of: (1) weighing; (2) adding the glacial acetic acid, the polysorbate-20, the glycerin and the purified water into the chitosan-iodine, mixing uniformly and dissolving completely; (3) dissolving the potassium iodate with the purified water, and adding the dissolved potassium iodate into the mixture to be stirred uniformly; (4) adding the chitosan to stir and dissolve; and (5) adding the purified water to 100% finally, slowly stirring to form the gel, standing and degassing to obtain a skin antimicrobial gel finished product. The skin antimicrobial gel has the advantages of no toxicity, no stimulus, good stability and no tolerance; and the skin antimicrobial gel is suitable for treating and preventing skin and subcutaneous infection and promoting wound healing, such as primary skin infection of impetigo vulgaris, furuncle and the like, secondary skin infection of eczema concurrent infection, trauma concurrent infection and the like as well as tinea manus and pedis, tinea corporis and tinea cruis which are caused by fungal infection.

Description

A kind of antibacterial skin gel formula and preparation method thereof

Technical field

The present invention relates to medical dressing, particularly contain the dressing of chitosan iodine, specifically, relate to the antibacterial skin gel.

Background technology

Iodine is used for the body sterilization history of existing 150 years, but the dissolubility in water is very little due to iodine, only has 1.315 * 10 under 25 ℃ ^-3Mol/L can not be made into aqueous formulation and use; At room temperature easily distillation, content is unstable; To the mucocutaneous shortcoming such as irritant and limited its extensive use.At present, widely used povidone iodine class disinfectant is take organic polymer or surfactant as carrier mostly, by network structure or the micelle that forms between carrier molecule, with the conformational effect in electronics and space with iodine " constraint " in wherein, thereby change the free state of iodine in general Operand, make its stability and bactericidal action enhancing, zest and xanthochromia reduction.But original micelle power can be destroyed after dilution for the finished product of this class take surfactant as carrier, makes the stability decreases of active iodine, thereby affect its sterilization effect.At present, most widely used povidone iodine class disinfectant is the povidone iodine complex in China, is recorded in version " two ones of Chinese pharmacopoeia in 2010.But polyvidone is less to the dissolubility of iodine, and molecular weight large (can up to 70000), more difficult being biodegradable, and life-time service can produce harmful effect to environment.In addition, itself there is no bactericidal action polyvidone, just forms micelle as a kind of surface activity carrier, improves the stability of iodine molecule.

Chitosan ( Chitosan) be the unique positively charged side chain polysaccharide of occurring in nature, have antibioticly, antitumor strengthens the functions such as immunity, has good biocompatibility, and nonirritant, has no side effect, due to 2-NH ₂Existence, chitosan has certain bacteria resistance function, but bacteriostasis property is limited, and is subject to the impact of the conditions such as chitosan molecule amount, deacetylation.Chitosan is a kind of macromolecular compound of biological property excellence, and after absorption iodine, the heat stability of iodine improves greatly, and is the same with other povidone iodine, and shell iodine can discharge elemental iodine, thereby has strong sterilization.This finished product is nontoxic, good stability, nonirritant.Bibliographical information has been arranged the sterilization effect of chitosan iodine (" laboratory observation of chitosan iodine liquid bactericidal effect ", Hengyang Medical College's journal (medicine) 05 phase in 2000), its chitosan raw material used is water-soluble chitosan.

In Chinese patent database, the patent application of gel preparation that can be used in antibacterial skin is few, " the nano silver antimicrobial gel for the treatment of women ' s genital tract infection is only arranged No. 200410029794.0, preparation method and application ", No. ZL200410010870.3 " Wood frog antibiotic peptides gel and preparation method thereof " and No. 200710011582.3 " a kind of slowly-released type nanometer silver antibacterial gel and preparation method thereof and use ", wherein second is take Wood frog antibiotic peptides as Antibacterial Constituents, and other two is take nanometer silver as Antibacterial Constituents.There is no at present the patent application of making the antibacterial skin gel of chitosan iodine.

Summary of the invention

The purpose of this invention is to provide a kind of good stability, the good antibacterial skin gel formula of bactericidal effect, make it the health service into the mankind.

Another purpose of the present invention is to provide the preparation method of above-mentioned antibacterial skin gel, enables to realize clinical practical application.

The antibacterial skin gel that the inventor provides, take chitosan iodine as main active, its raw materials quality formula is as follows:

Chitosan iodine 0.2%～5%

Glacial acetic acid 0.1%～2.5%

Tween-20 0.6%～15%

Glycerol 0.5%～12.5%

Potassium iodate 0.005%～0.150%

Chitosan 3%～10%

Purified water adds to 100%.

The raw material preferred mass formula of above-mentioned antibacterial skin gel is as follows:

Chitosan iodine 1.0%～3.0%

Glacial acetic acid 0.4%～1.6%

Tween-20 1.0%～10.0%

Glycerol 2.5%～5.5%

Potassium iodate 0.005%～0.100%

Chitosan 3%～8%

Purified water adds to 100%.

Above-mentioned chitosan iodine is that water-insoluble chitosan and iodine get through complexation reaction preparation.

Above-mentioned glacial acetic acid, Tween-20, glycerol, potassium iodate, purified water all meet the requirement of the Pharmacopoeia of the People's Republic of China.

The preparation method of the antibacterial skin gel that the inventor provides comprises the following steps:

1. according to the weighing of raw materials quality formula, standby;

2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby;

3. the purified water that takes a morsel dissolving potassium iodate, and join in standby material and mix, stir;

4. add chitosan according to the raw materials quality formula, stir and make the chitosan dissolving;

5. last, add remaining purified water to 100%, slowly stir and make into gel, standing, degassed, namely get the antibacterial skin finished gel.

The inventor points out: the chitosan iodine in the antibacterial skin gel plays disinfection, promotes healing, glacial acetic acid is used for regulating pH value, and play collaborative solubilizing effect, Tween-20 mainly plays solubilization, glycerol plays blending and moisture-keeping function, potassium iodate plays stabilizer function, and chitosan can sterilize, stop blooding, and purified water is diluent.Therefore, the antibacterial skin gel has the effect of broad-spectrum sterilization, antipruritic, antiinflammatory, to gram positive bacterias such as staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, bacillus subtilises, to gram negative bacterias such as escherichia coli, Pseudomonas aeruginosa, gonococcuss, to funguses such as Candida albicans, epidermophyton, trichophytons, acid-fast bacillis such as tubercule bacillus etc. all there is killing action.Discharge active iodine after chitosan iodine and mucocutaneous the contact, the latter can directly act on the pathogenic microorganism body protein, disturbs it amino acid whose synthetic, reduces the lipid film mobility, thereby makes pathogenic microorganism dead.This product has simultaneously hemostasis, promotes the effect of wound tissue healing.

Antibacterial skin gel of the present invention is nontoxic, nonirritant, good stability, does not produce toleration; Be applicable to treatment and prevention skin and subcutaneous infection and promote wound healing, as: the primary cutaneous such as impetigo, furuncle and phyma infect; The Secondary cases skin infections such as eczema concurrent infection, wound concurrent infection; The tinea manus and pedis that fungal infection causes, tinea corporis, tinea cruris etc.

The specific embodiment

Describe the specific embodiment of the present invention in detail by the following example

EXAMPLE lAccording to following raw materials according quality formula weigh batching: chitosan iodine 0.2g, glacial acetic acid 0.1g, Tween-20 0.6g, glycerol 0.5g, potassium iodate 0.005g, chitosan 3g adds purified water to 100g.Add glacial acetic acid, Tween-20, glycerol, purified water to stir in chitosan iodine, make dissolving fully, standby; The purified water that takes a morsel afterwards dissolving potassium iodate, and join in standby material and mix, stir; Add again the recipe quantity chitosan, stir and make the chitosan dissolving; Final purification water adds to 100g, slowly stirs, and makes the antibacterial skin finished gel.

Embodiment 2According to following raw materials according quality formula weigh batching: chitosan iodine 1g, glacial acetic acid 0.5 g, Tween-20 3g, glycerol 2.5g, potassium iodate 0.025g, chitosan 7g adds purified water to 100g.Method for making obtains the antibacterial skin finished gel with embodiment 1.

Embodiment 3According to following raw materials according quality formula weigh batching: chitosan iodine 5g, glacial acetic acid 2.5 g, Tween-20 15g, glycerol 12.5g, potassium iodate 0.125g, chitosan 10g, purified water adds to 100g.Method for making obtains the antibacterial skin finished gel with embodiment 1.

Claims (4)

1. an antibacterial skin gel, is characterized in that it take chitosan iodine as main active, and its raw materials quality formula is as follows:

Chitosan iodine 0.2%～5%

Glacial acetic acid 0.1%～2.5%

Tween-20 0.6%～15%

Glycerol 0.5%～12.5%

Potassium iodate 0.005%～0.150%

Chitosan 3%～10%

Purified water adds to 100%.

2. antibacterial skin gel as claimed in claim 1 is characterized in that the raw materials quality formula of this gel is as follows:

Chitosan iodine 1.0%～3.0%

Glacial acetic acid 0.4%～1.6%

Tween-20 1.0%～10.0%

Glycerol 2.5%～5.5%

Potassium iodate 0.005%～0.100%

Chitosan 3%～8%

Purified water adds to 100%.

3. antibacterial skin gel as described in one of claim 1 or 2, is characterized in that described chitosan iodine is that water-insoluble chitosan and iodine get through complexation reaction preparation.

4. the method for preparing the described antibacterial skin gel in one of claim 1 or 2, its feature comprises the following steps:

1. according to the weighing of raw materials quality formula, standby;

2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby;

3. the purified water that takes a morsel dissolving potassium iodate, and join in standby material and mix, stir;

4. add chitosan according to the raw materials quality formula, stir and make the chitosan dissolving;

5. last, add remaining purified water to 100%, slowly stir and make into gel, standing, degassed, namely get the antibacterial skin finished gel.