CN103191838A - Curved surface body container for plasma continuous separation - Google Patents
Curved surface body container for plasma continuous separation Download PDFInfo
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- CN103191838A CN103191838A CN201210003575XA CN201210003575A CN103191838A CN 103191838 A CN103191838 A CN 103191838A CN 201210003575X A CN201210003575X A CN 201210003575XA CN 201210003575 A CN201210003575 A CN 201210003575A CN 103191838 A CN103191838 A CN 103191838A
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Abstract
The invention relates to a curved surface body container used for plasma continuous separation. A separation lacuna is arranged inside the curved surface body container, blood is injected into the separation lacuna, the separation lacuna rotates at a high speed around the rotating shaft of the curved surface body container, blood components are separated by using centrifugal force according to density size, segmentation and regionalization are formed inside the separation lacuna, whole blood input is performed and visible components such as plasma, blood corpuscle and the like are respectively extracted out to achieve dynamical equilibrium, and continuous collection of a single component of plasma is achieved. In the invention, by optimally designing internal forms of the curved surface body container, closely linked to plasma flow rate, separation lacuna height, plasma separating factors, curve factors and the like, the thickness of the separation lacuna, particularly the thickness of a part close to a separation interface, is controlled, the curved surface body container is enabled to be more reasonable and has the advantage of improving single plasma collecting efficiency and quality.
Description
Technical field
The present invention relates to blood constituent and separate, particularly relate to the blood plasma continuous centrifugal and separate thinking and the method for designing of gathering mean camber body container optimal design, make the curved body container more reasonable.
Background technology
No matter be scientific research or clinical medicine practice or industrial production, and more conditions, all need blood is separated, as going out single component from separation of whole blood, usually use centrifugal process from blood, to isolate various single components, be used for occasions such as clinical treatment, scientific research or preparation raw material.Modal is that whole blood is isolated red blood cell, granulocyte, monocyte, blood platelet and blood plasma by centrifugal separation system, and red blood cell and cleaning solution are isolated in the FRC washing after maybe will thawing.
The operation principle of continuous centrifugal separation system is: the primary structure of said system includes centrifuge, infusion pump and control device; By the infusion pipeline that is connected with infusion pump blood is introduced on the centrifuge in the soft bag in the knock-out drum, rotate knock-out drum at a high speed, and this soft bag synchronous high-speed rotation of drive, the not same-action that blood in it is subjected to centrifugal force field causes visible components such as blood plasma and blood cell to do the centrifugal sedimentation campaign, and by the big or small layering of density or proportion or sedimentation coefficient separately; When reaching sedimentation equilibrium, arrange each single component layer of forming concentric circles by the density height to low enrichment to the axle center from periphery radially, utilize infusion pump again the single component layer that separates to be extracted then.
The blood single component realizes that in this system continuous acquisition is rotary power to be provided and to play the effect of continuous input and extraction by airtight flexible pipe, the soft bag that separates in one end of flexible pipe and the knock-out drum is communicated with, with the knock-out drum high-speed rotation, the other end of flexible pipe is fixed on the support, therefore, flexible pipe one end rotates an end to be fixed, there is in the middle of it coil arrangement to realize that the flexible pipe solution of untwisting twines, make under rotation status, whole blood to be inputed in the knock-out drum of rotation, and in the knock-out drum of rotation, extract single components such as blood plasma and blood cell out.Knock-out drum, i.e. separator disk combines with coil arrangement and to have realized that the blood continuous centrifugal separates.
What relate to the separator disk that is applied on the blood continuous centrifugal separation equipment and coil arrangement in the prior art mainly contains US Patent No. 5360542.In this patent, separator disk be one columnar structured, be called knock-out drum, a columnar lacuna is arranged in it, soft bag is placed on the centrifugation that realizes blood in the circular lacuna; Coil arrangement includes underframe, rotatable top-support suspends knock-out drum in midair on the top-support, flexible pipe extend into the knock-out drum bottom fixedly pass two bearings of top-support side from the cabinet place after, the end of its flexible pipe is a square spigot, extend in the square groove of knock-out drum central axis.Flexible pipe is hollow structure, and several transfer pipelines are arranged in it, realizes that simultaneously power provides and the liquid conveying function.Based on above-mentioned structure, power makes top-support rotation, drives flexible pipe and untwists and produce torque forces, and this power is transferred to knock-out drum make it to produce in the same way and rotate, and then realize the separation process of blood continuous centrifugal.
Disclosed the separator disk of another version in the Chinese patent application 200710046991.7.Point out in this patent: the separator disk on the many cells composition mixing material piece-rate system, comprise durable hard chassis and disposable soft bag, the circular discs of being formed by inner core and base on the hard chassis, between inner core and base, form one section around continuous lacuna this one week of hard chassis circle core shaft and that stem and afterbody do not seal, soft bag is for being provided with single cavity configuration of liquid inlet and outlet pipe, and this soft bag can be inserted in the described lacuna.Because everywhere centrifugal force is inconsistent in the described continuous lacuna, therefore under the centrifugal force continuous action, each composition of mixing material is the segmentation distribution in soft bag, can extract corresponding single component in above-mentioned segmentation.Above-mentioned inner core is equivalent to described interior cylinder, base is equivalent to described outer cylinder.Above-mentioned hard chassis that is to say separator disk.
No matter be foreign patent or domestic patent, all adopted separator disk to add the mode of soft bag, soft bag is disposable consumptive material parts.The mentality of designing difference that the separator disk of these two kinds of forms separates owing to blood in actual use, the former is concentric design, and the latter is non-concentric design, and the latter's separative efficiency improves a lot than the former.Though the latter is comparatively ingenious with the design that separates soft bag on hard chassis, and certain effect is arranged in practice, but still the leeway of the design of improving is arranged.
Summary of the invention
The objective of the invention is to prior art is improved design, in the hope of improving the efficient that the blood plasma continuous centrifugal separates efficiently.The present invention relates to a kind of curved body container for the continuous separation of blood plasma, curved body container of the present invention can improve Plasma Pheresis/Apheresis Plasma efficient and quality in blood plasma separates continuously.
In order to reach the foregoing invention purpose, the invention provides following technical scheme:
A kind of for the continuous curved body container that separates of blood plasma, it is characterized in that, be provided with the separation lacuna in the described curved body container, described separation lacuna is the curved body that includes lateral wall and madial wall, and this lateral wall curved surface that separates lacuna curve of projection on perpendicular to the plane of rotating shaft is as follows with polar coordinate representation:
Wherein, polar limit O is the intersection point on rotating shaft and described plane, and polar pole axis L is the directions of rays that limit arrives the curve most proximal end, the positive direction of polar angle is counterclockwise, r is any utmost point of some footpath on the curve, and R is the utmost point footpath of curve distal-most end, θ
1Be the polar angle of curve initiating terminal, its value is 0 degree of this polar coordinate system, θ
2Be curve and plasma separation factor critical radius F
rThe polar angle of intersection point, plasma separation factor critical radius F
rThe required minimum centrifugal radius of plasma separation in unit interval when determining for rotating speed, θ
3Be a polar angle, its value is θ
21.5～3.5 times, θ
4Polar angle for the curve distal-most end; In described separation lacuna, [θ
1, θ
2) be the blood plasma district, [θ
2, θ
3) be the chaotic region, [θ
3, θ
4] be the blood cell district, b
1Be the curve coefficients in blood plasma district, b
2Be the curve coefficients of chaotic region, b
3Curve coefficients for the blood cell district; This madial wall curved-surface shape that separates lacuna can be identical with lateral wall, also can be inequality, and θ
2＇ is for separating lacuna madial wall curve and plasma separation factor critical radius F
rThe polar angle of intersection point; Blood plasma district, chaotic region, blood cell district have different separation and collection effect when adopting inconsistent lacuna thickness, but close on that the average thickness in zone is a design control parameter before and after the plasma separation interface separating lacuna; Described separation lacuna is at [θ
2, θ
2＇] the interval be to close on the separated space zone that forms the plasma separation interface, the curved surface of separation lacuna lateral wall and madial wall at spacing or the average headway D of rotating shaft vertical plane Projective Curve is this interval in:
Wherein K is constant, and v is that blood plasma is at [θ
2, θ
2＇] interval interior flow velocity, h is for separating lacuna at the axial height of rotation, F (n
2, r) for separating lacuna at [θ
2, θ
2＇] interval interior centrifugal force.The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when identical in interval, it separates lacuna thickness and equates, so the curved surface of this separation lacuna lateral wall and madial wall is D in the spacing of rotating shaft vertical plane Projective Curve; The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] in the interval not simultaneously, it is unequal that it separates lacuna thickness, the curved surface of this separation lacuna lateral wall and madial wall is D at the average headway of rotating shaft vertical plane Projective Curve.
Space D is at interval [θ
2, θ
2＇] in be directly proportional with plasma flow rate, when constant and plasma flow rate increases when required separative efficiency, the blood plasma axial flow increases the drag force effect that is in the visible components such as blood cell of closing on separating interface, so can in this interval, increase this interval cavity volume by increasing spacing, reduce the flow velocity of blood plasma in this interval, reduce the blood plasma axial flow to being in the drag force effect of the visible components such as blood cell of closing on separating interface to reach.
Space D is at interval [θ
2, θ
2＇] in separate the lacuna height and be inversely proportional to, when separating the increase of lacuna height, the separation cavity volume in this interval is increased, increase the time that blood plasma stops in this interval, reduced separative efficiency, so control this interval separation cavity volume by adjusting spacing, to keep the flow velocity of blood plasma in this interval.
Space D is at interval [θ
2, θ
2＇] in be inversely proportional to the curved body arc length, when the curved body arc length increased, the separation cavity volume in this interval increased, increase the time that blood plasma stops in this interval, reduced separative efficiency, thus this interval cavity volume controlled by adjusting spacing, to keep the flow velocity of blood plasma in this interval.
Space D with separate lacuna at interval [θ
2, θ
2＇] in the centrifugal force size be inversely proportional to.All under the constant situation, centrifugal force increases in the height of plasma flow rate, curved body and arc length, and blood plasma can reduce in the time that this interval domestic demand stops, so reduce this interval and separate cavity volume by reducing spacing; Square being directly proportional of the size of centrifugal force and rotating speed is directly proportional with separation semidiameter, so rotating speed or separation semidiameter can reduce this interval cavity volume by reducing spacing when increasing.
In conditions such as rotating speed, separation semidiameter, whole blood input flow velocity, curved body arc length all under the constant situation, only change and separate lacuna, when spacing is widened, make at this interval plasma separation interface because blood plasma axial flow face is widened the unstable eddy current that input produces with whole blood increases, cause the separating interface diffusion, directly influence separating effect and efficient; When spacing narrowed down, because the axial flow face of blood plasma diminishes, flow velocity was accelerated, and the blood plasma axial flow increases the drag force effect of visible components such as blood cell, and visible component such as blood cell is strengthened to the near-end disperse of blood plasma district, also can influence separating effect.
Based on the foregoing invention content, the present invention carries out in the method that continuous centrifugal separates comparing with method of the prior art to blood and has following technique effect:
1. the present invention is in order to realize that the blood continuous centrifugal separates more efficiently, the factor that influences the design of curved body container from analyze the continuous centrifugal separation process is set about, confirming to separate lacuna thickness is a key factor in the design link, the Optimization Design of the curved body container of a continuous centrifugal separation has been proposed based on this thought, this curved body internal tank shows as one and separates lacuna, can hold one in this separation lacuna and separate soft bag, separate soft bag during blood engorgement and separate the lacuna inside and outside wall formation separated space that fits, blood carries out segmentation and regionalization according to the density difference in the separated space that curved surface constitutes, the thickness that separates lacuna directly influences plasma separation efficient by separated space, therefore to separating the lacuna optimal design in the curved body container, control separates lacuna, and especially it closes on the thickness of separating interface part, in the hope of improving plasma separation efficient.
2. the present invention is by optimizing and revising and control the design parameter of curved body container, and then influences the plasma separation interface, realizes not increasing separation costs, and can improve output and the quality of separated product.
Description of drawings
Fig. 1 is the centrifugal separation system structural representation.
Fig. 2 is the curved body structural representation.
The curve synoptic diagram of Fig. 3 projection on perpendicular to the plane of rotating shaft that is the outer wall curved surface that separates lacuna.
Fig. 4 separates the curved surface form of lacuna lateral wall and madial wall at [θ
2, θ
2＇] when identical in interval, at rotating shaft vertical plane Projective Curve spacing schematic diagram.
Fig. 5 separates the curved surface form of lacuna lateral wall and madial wall at [θ
2, θ
2＇] in the interval not simultaneously, at the average headway schematic diagram of rotating shaft vertical plane Projective Curve.
Fig. 6 separates lacuna along the axial generalized section of rotation.
The specific embodiment
The method of coming the present invention to be used for raising blood plasma continuous centrifugal separative efficiency below in conjunction with the drawings and specific embodiments is described in further detail; in the hope of understanding version of the present invention and concrete workflow more lucidly, but can not limit protection scope of the present invention with this.
The invention belongs to a kind of method for designing for the continuous curved body container that separates of blood plasma.As shown in Figure 1, the principle of this method is to place one to have the curved body container that separates lacuna blood, rotates this separation container by high speed, thereby blood plasma in the blood and other visible components are separated.Density differs and is red blood cell and blood plasma to the maximum in the blood, erythrocytic density maximum wherein, and the density minimum of blood plasma, and also the blood plasma of single component and red blood cell are the blood constituents of expense maximum in the medical science.Therefore, the blood plasma in the blood being carried out the continuous centrifugal separation is the most basic, the simplest component separation.
In order to separate in the collection continuously at the blood plasma single component, improve Plasma Pheresis/Apheresis Plasma efficient and quality, so by optimal design and plasma flow rate, separate lacuna height, plasma separation factor, the closely related curved body internal tank form of curve coefficients, control separates lacuna, and especially it closes on the thickness of separating interface part, make the curved body container more reasonable, as shown in Figure 2, described separation lacuna 3 includes outer wall 2 and inwall 1, and this outer wall curved surface that separates lacuna curve of projection on perpendicular to the plane of rotating shaft is as follows with polar coordinate representation:
Wherein, as shown in Figure 3, polar limit O is the intersection point on rotating shaft and described plane, polar pole axis L is the ray that limit arrives curve initiating terminal direction, and the positive direction of polar angle is clockwise direction, and r is any utmost point of some footpath on the curve, R is the utmost point footpath of curve distal-most end, θ
1Be the polar angle of curve initiating terminal, its value is 0 degree of this polar coordinate system, θ
2Be curve and plasma separation factor critical radius F
rThe polar angle of intersection point, plasma separation factor critical radius F
rThe required minimum centrifugal radius of plasma separation in unit interval when determining for rotating speed, θ
3Be a polar angle, its value is θ
21.5～3.5 times, θ
4Polar angle for the curve distal-most end; In described separation lacuna, [θ
1, θ
2) be the blood plasma district, [θ
2, θ
3) be the chaotic region, [θ
3, θ
4] be the blood cell district, b
1Be the curve coefficients in blood plasma district, b
2Be the curve coefficients of chaotic region, b
3Curve coefficients for the blood cell district; This madial wall curved-surface shape that separates lacuna can be identical with lateral wall, also can be different, and θ
2＇ is for separating lacuna madial wall curve and plasma separation factor critical radius F
rThe polar angle of intersection point; Blood plasma district, chaotic region, blood cell district have different separation and collection effect when adopting inconsistent lacuna thickness, but close on that the average thickness in zone is a design control parameter before and after the plasma separation interface separating lacuna; Described separation lacuna is at [θ
2, θ
2＇] the interval be to close on the separated space zone that forms the plasma separation interface, the curved surface of separation lacuna lateral wall and madial wall at spacing or the average headway D of rotating shaft vertical plane Projective Curve is this interval in:
Wherein K is constant, and v is that blood plasma is at [θ
2, θ
2＇] interval interior flow velocity, h is for separating lacuna at the axial height of rotation, F (n
2, r) for separating lacuna at [θ
2, θ
2＇] interval interior centrifugal force.The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when identical in interval, it separates lacuna thickness and equates, as shown in Figure 4, so the curved surface of this separation lacuna lateral wall and madial wall is D in the spacing 4 of rotating shaft vertical plane Projective Curve; The curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] in the interval not simultaneously, it is unequal that it separates lacuna thickness, as shown in Figure 5, this curved surface that separates lacuna lateral wall and madial wall is D at the average headway 5 of rotating shaft vertical plane Projective Curve, and D1, D2, D3 are for separating the spacing of three diverse locations of lacuna among Fig. 5.
Space D is at interval [θ
2, θ
2＇] in be directly proportional with plasma flow rate v, when constant and plasma flow rate increases when required separative efficiency, the blood plasma axial flow increases the drag force effect that is in the visible components such as blood cell of closing on separating interface, increase this interval cavity volume so can in this interval, increase spacing by design, reduce the flow velocity of blood plasma in this interval, reduce the blood plasma axial flow to being in the drag force effect of the visible components such as blood cell of closing on separating interface to reach.
Space D is at interval [θ
2, θ
2＇] in separate lacuna height h and be inversely proportional to, when separating the increase of lacuna height, the separation cavity volume in this interval is increased, increase the time that blood plasma stops in this interval, reduced separative efficiency, so control this interval separation cavity volume by adjusting spacing, to keep the flow velocity of blood plasma in this interval.
Space D is at interval [θ
2, θ
2＇] in be inversely proportional to the curved body arc length, when the curved body arc length increased, the separation cavity volume in this interval increased, increase the time that blood plasma stops in this interval, reduced separative efficiency, thus this interval cavity volume controlled by adjusting spacing, to keep the flow velocity of blood plasma in this interval.
Space D with separate lacuna at interval [θ
2, θ
2＇] interior centrifugal force size F (n
2, r) be inversely proportional to.All under the constant situation, centrifugal force increases in the height of plasma flow rate, curved body and arc length, and blood plasma can reduce in the time that this interval domestic demand stops, so reduce this interval and separate cavity volume by reducing spacing; Square being directly proportional of the size of centrifugal force and rotating speed is directly proportional with separation semidiameter, so rotating speed or separation semidiameter can reduce this interval cavity volume by reducing spacing when increasing.
In rotating speed, separation semidiameter, whole blood input flow velocity, curved body arc length all under the constant situation, only change and separate lacuna, when spacing is widened, make at this interval plasma separation interface because blood plasma axial flow face is widened the unstable eddy current that input produces with whole blood increases, cause the separating interface diffusion, directly influence separating effect and efficient; When spacing narrowed down, because the axial flow face of blood plasma diminishes, flow velocity was accelerated, and the blood plasma axial flow increases the drag force effect of visible components such as blood cell, and visible component such as blood cell is strengthened to the near-end disperse of blood plasma district, also can influence separating effect.
As shown in Figure 6, can hold one in this separation lacuna and separate soft bag, separate soft bag during blood engorgement and separate the lacuna inside and outside wall formation separated space that fits, blood carries out segmentation and regionalization according to the density difference in the separated space that curved surface constitutes, therefore to separating the lacuna optimal design in the curved body container, realize not increasing separation costs, and can improve output and the quality of separated product.
Embodiment 1
The separation lacuna of present embodiment mean camber body container is made of outer separator disk madial wall and interior separator disk lateral wall, and the lateral wall of this separation lacuna is identical with the curved surface form of madial wall, and its spacing D is:
Wherein, constant K equals 1.725*10
6, plasma flow rate is 80ml/min, separates lacuna height 50mm, the curved body arc length is 120mm, b
2=0.2, θ
2=90
o, θ
2＇=145
o, separate lacuna [90
o, 145
o] centrifugal force in interval is 2300g, drawing the spacing or the average headway that separate lacuna is 10mm.
After whole blood is full of whole separation lacuna, whole blood continues input from blood inlet, and blood plasma continues from visible components such as blood plasma mouth and blood cells from the blood cell mouth to extract out, and input quantity equates with discharge, make the total liquid volume of separating in the lacuna keep balance, thereby can realize the purpose of blood plasma continuous acquisition.
Undoubtedly, the structure that the present invention enumerates in above-described embodiment the method that the blood continuous centrifugal separates form and curve form, can also be formed and curve form by other similar structures.Generally speaking, protection scope of the present invention also comprises other conversion that it will be apparent to those skilled in the art that and substitutes.
Claims (3)
1. one kind is used for the curved body container that blood plasma separates continuously, it is characterized in that, be provided with the separation lacuna in the described curved body container, described separation lacuna is the curved body that includes lateral wall and madial wall, and this lateral wall curved surface that separates lacuna curve of projection on perpendicular to the plane of rotating shaft is as follows with polar coordinate representation:
Wherein, polar limit O is the intersection point on rotating shaft and described plane, and polar pole axis L is the ray that limit arrives curve initiating terminal direction, the positive direction of polar angle is clockwise direction, r is any utmost point of some footpath on the curve, and R is the utmost point footpath of curve distal-most end, θ
1Be the polar angle of curve initiating terminal, its value is 0 degree of this polar coordinate system, θ
2Be curve and plasma separation factor critical radius F
rThe polar angle of intersection point, plasma separation factor critical radius F
rThe required minimum centrifugal radius of plasma separation in unit interval when determining for rotating speed, θ
3Be a polar angle, its value is θ
21.5～3.5 times, θ
4Polar angle for the curve distal-most end; In described separation lacuna, [θ
1, θ
2) be the blood plasma district, [θ
2, θ
3) be the chaotic region, [θ
3, θ
4] be the blood cell district, b
1Be the curve coefficients in blood plasma district, b
2Be the curve coefficients of chaotic region, b
3Curve coefficients for the blood cell district; θ
2＇ is for separating drop shadow curve and the plasma separation factor critical radius F of lacuna madial wall curved surface
rThe polar angle of intersection point; Described separation lacuna is at [θ
2, θ
2＇] interval in the curved surface of this separation lacuna lateral wall and madial wall in the space D of rotating shaft vertical plane Projective Curve be:
Wherein K is constant, and v is that blood plasma is at [θ
2, θ
2＇] interval interior flow velocity, h is for separating lacuna at the axial height of rotation, F (n
2, r) for separating lacuna at [θ
2, θ
2＇] interval interior centrifugal force.
2. according to claim 1 a kind of for the continuous curved body container that separates of blood plasma, it is characterized in that the curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] when identical in interval, it separates lacuna thickness and equates that the curved surface of this separation lacuna lateral wall and madial wall is D in the spacing of rotating shaft vertical plane Projective Curve.
3. according to claim 1 a kind of for the continuous curved body container that separates of blood plasma, it is characterized in that the curved surface form of described separation lacuna lateral wall and madial wall is at [θ
2, θ
2＇] in the interval not simultaneously, it is unequal that it separates lacuna thickness, the curved surface of this separation lacuna lateral wall and madial wall is D at the average headway of rotating shaft vertical plane Projective Curve.
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|---|---|---|---|
| CN201210003575.XA CN103191838B (en) | 2012-01-09 | 2012-01-09 | Curved surface body container for plasma continuous separation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210003575.XA CN103191838B (en) | 2012-01-09 | 2012-01-09 | Curved surface body container for plasma continuous separation |
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| CN103191838A true CN103191838A (en) | 2013-07-10 |
| CN103191838B CN103191838B (en) | 2014-05-28 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342420A (en) * | 1979-09-28 | 1982-08-03 | Gambro Dialysatoren Kg | Device for separating liquids, especially whole blood |
| US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
| US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
| US20060240964A1 (en) * | 2005-04-21 | 2006-10-26 | Fresenius Hemocare Deutschland Gmbh | Method and apparatus for separation of particles suspended in a fluid |
| CN101172207A (en) * | 2007-10-12 | 2008-05-07 | 经建中 | Separator disk on multi-cell component mix liquid separating system and application method of the same |
| CN202526652U (en) * | 2012-01-09 | 2012-11-14 | 金卫医疗科技(上海)有限公司 | Curved surface container for controlling separation interface |
-
2012
- 2012-01-09 CN CN201210003575.XA patent/CN103191838B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342420A (en) * | 1979-09-28 | 1982-08-03 | Gambro Dialysatoren Kg | Device for separating liquids, especially whole blood |
| US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
| US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
| US20060240964A1 (en) * | 2005-04-21 | 2006-10-26 | Fresenius Hemocare Deutschland Gmbh | Method and apparatus for separation of particles suspended in a fluid |
| CN101172207A (en) * | 2007-10-12 | 2008-05-07 | 经建中 | Separator disk on multi-cell component mix liquid separating system and application method of the same |
| CN202526652U (en) * | 2012-01-09 | 2012-11-14 | 金卫医疗科技(上海)有限公司 | Curved surface container for controlling separation interface |
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| CN103191838B (en) | 2014-05-28 |
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