CN103251479A - Schlemm canal expansion stent - Google Patents
Schlemm canal expansion stent Download PDFInfo
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- CN103251479A CN103251479A CN2013101917511A CN201310191751A CN103251479A CN 103251479 A CN103251479 A CN 103251479A CN 2013101917511 A CN2013101917511 A CN 2013101917511A CN 201310191751 A CN201310191751 A CN 201310191751A CN 103251479 A CN103251479 A CN 103251479A
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Abstract
The invention discloses a Schlemm canal expansion stent which is in a one-way spiral shape. The outer diameter of the expansion stent is matched with the inner diameter of a Schlemm canal. The length of the expansion stent is matched with the length of the Schlemm canal. Or, the length of the expansion stent is matched with the length of the nidus of the Schlemm canal. The expansion stent can also be a secondary expansion stent. Or, the expansion stent is formed by connecting a plurality of secondary expansion stents in series. The Schlemm canal expansion stent is simple in structure, low in manufacturing process requirement, low in manufacturing cost, and beneficial for popularization and application. The Schlemm canal expansion stent is not only suitable for treatment of a late glaucoma patient, but also suitable for treatment of an early glaucoma patient and treatment of a secondary glaucoma patient.
Description
Technical field
The present invention relates to a kind of ophthalmic support, especially relate to and a kind ofly execute Lai Mushi pipe (Schlemm) expandable stent for what insert that ophthalmic executes Lai Mushi pipe (Schlemm).
Background technology
Glaucoma is a kind of very serious public health disease, and glaucoma is a kind of optic nerve disease (optic nerve disease) more specifically, and it is not smooth that it is generally the ophthalmic aqueous humor drainage, produces intraocular pressure and raises.Pressure in the eyes raises, and makes optic nerve injury, and field range is dwindled.When there is lasting high intraocular pressure in the patient, can cause the patient blind.
Eyes are hollow-core construction, comprise the transparent fluid that is called " aqueous humor ".Aqueous humor is formed in the back room of eyes by the speed of corpus ciliare with about 2.5 microlitre per minutes.The fluid that produces with suitable constant speed is process around the crystalline lens again, and enters in the anterior chamber of eyes by the pupil opening in the iris.In case in the anterior chamber, this fluid is discharged eyes by two different routes.In " uvea sclera (uveoscleral) " path, fluid filters between capsulociliary muscle fiber.This route accounts for about 10 of the aqueous humor that flows out human body.The major avenues of approach of flowing out the aqueous humor of human body is by " tubule " route, and this route relates to trabecular reticulum and Schlemm pipe (executing the Lai Mushi pipe).
Trabecular reticulum and execute Lai Mushi pipe (Schlemm) junction between iris and sclera.Trabecular reticulum is the wedge structure that extends around the periphery of eyes.It comprises the collagen bundle that is arranged to three-dimensional screen shape structure, and this collagen bundle aligns with the cell monolayer that is called trabecular meshwork cell.The outer wall of trabecular reticulum overlaps with the inwall of executing Lai Mushi pipe (Schlemm).Executing Lai Mushi pipe (Schlemm) is the tubular structure that extends around the periphery of cornea.In the adult, think execute Lai Mushi pipe (Schlemm) by in every being divided into a series of independently closed end pipes.
The aqueous humor fluid is crossed the inwall of executing Lai Mushi pipe (Schlemm) and is entered in this pipe by the space between the girder bundle, and enters the episcleral veins system by collecting conduit from a series of (about 25) that execute Lai Mushi pipe (Schlemm) discharge.Under normal circumstances, the generation of aqueous humor equals the discharge of aqueous humor, and intraocular pressure remains in 15 to 21mmHg the scope quite consistently.In glaucoma, high unusually by the resistance of tubule outflow system.
In primary open-angle glaucoma (this primary open-angle glaucoma is modal glaucoma form), think that unusual resistance is the outside and the inwall of executing Lai Mushi pipe (Schlemm) along trabecular reticulum.Primary open-angle glaucoma accounts for whole glaucomatous about 60 percent.The stream that goes out that the glaucoma of other form (for example angle sealing glaucoma and supervention glaucoma) also relates to by executing Lai Mushi pipe (Schlemm) path reduces, but the resistance increase is owing to other reason, for example machinery obstruction, inflammation remains, cell obstruction etc.
Owing to increase resistance, will accumulate the aqueous humor fluid, because aqueous humor can not be discharged fast enough.When fluid accumulation, the intraocular pressure (IOP) in the eyes raises.Elevated IOP will be compressed the neural axon in the optic nerve, also may influence the blood vessel of optic nerve is supplied with.Optic nerve sends vision to brain from eyes.Feasible glaucoma treatment method only reduces intraocular pressure at present.
Glaucomatous clinical treatment adopts progressively mode.Drug therapy normally first treatment is selected.Can be topical or oral administration, the effect of these medicines is to reduce the aqueous humor generation, and perhaps they are for increasing discharge.Present obtainable medicine has a lot of serious adverse, comprising: congestive heart disease, rapid breathing, hypertension, depression, nephrolith, aplastic anemia, sexual dysfunction and death.The compliance of medicine is subject matter, and according to estimates, the glaucoma patient who surpasses half does not follow their orthochronous dosage, thereby causes the fluctuation of intraocular pressure, causes optic nerve injury and defect of visual field.
When reducing intra-ocular pressure power, carry out laser trabeculoplasty when under medication usually.In laser trabeculoplasty, the heat energy that is produced by laser is applied on a plurality of discontinuity poinies in the trabecular reticulum.It is believed that laser energy stimulates the metabolism of trabecular meshwork cell in some way, and change the extracellular material in trabecular reticulum.In about patient of 80 percent, the flow of aqueous humor output increases, and IOP reduces.But, this effect can not continue the long period usually, and 50 percent patient developed into high pressure in 5 years.Laser surgery can not be reused usually.In addition, the laser trabeculoplasty transplantation can not effectively be treated the patient's who is lower than 50 years old primary open-angle glaucoma, can not effectively treat angle sealing glaucoma and a lot of supervention glaucoma.When the laser trabeculoplasty transplantation can not fully reduce pressure, will carry out trabeculectomy so.By trabeculectomy, form hole at sclera and anterior chamber zone, this hole can make aqueous humor leave eyes by optional route.
The most common processing mode of carrying out of glaucoma patient is trabeculectomy, and this art formula can form artificial aqueous humor outflow pathway.Yet trabeculectomy can form the paralysed traceization of scleral flap, makes the aqueous humor of artificial formation flow out pathway closure, thereby causes that intraocular pressure raises again, particularly for child and early youth.Successfully carrying out in the eyes of trabeculectomy at first, in three to five years, 80 percent will be owing to the paralysed traceization that filters passage lost efficacy after operation.Trabeculectomy has produced the path that makes aqueous humor go out ocular surface.Simultaneously, it has produced to make and has lived in the path that ocular surface and superciliary antibacterial enter eyes usually.When this thing happens, the interior eye infections of ophthalmia in may being called.Endophthalmitis causes permanent and bigger vision loss usually.
In addition, existing aqueous humor drainage device also can form the aqueous humor outflow pathway and reduce intraocular pressure.Aqueous humor drainage device is to be silicone tube, and an end of this silicone tube is installed on plastics (polypropylene or other synthetic) plate.For the aqueous humor part flow arrangement, in conjunctiva, form otch, thereby expose sclera.Plastic plate is sewn on the eyes posterior face, usually the crossing the line line.The hole of through thickness is formed in the eyes at the edge place by pin usually.Pipe inserts in the eyes by this hole.The outside of pipe is covered by donor sclera or pericardium.Put back to conjunctiva, and closure of incisions tightly.The aqueous humor part flow arrangement has a lot of complication.The wall that thickens of the scar tissue that forms around plastic plate provides certain resistance to outflow, much will limit reducing of eyes pressure in the eyes.In a lot of eyes, because it is also unrestricted to flow through the fluid stream of pipe, therefore form hypotonia.Absorbable stitching thread on a lot of doctor's surrounding tube subsystems, and wait for that this stitching thread dissolves after operation, this time is enough to form the scar cell around plate.Some device is included in the pressure sensitive valve in the pipe, but these valves can not be worked well.Operation is carried out in posterior orbit, and a lot of patients form eye muscle imbalance and diplopia after operation.For the aqueous humor part flow arrangement of prior art, produced and make antibacterial enter passage in the eyes, and may produce endophthalmitis.
Most of problem of existing glaucoma treatment device and processing is because aqueous humor is discharged to ocular surface from inside ofeye.Therefore, need more meet physiological system, discharge to the aqueous humor fluid of executing in the Lai Mushi pipe (Schlemm) in order to increase from the anterior chamber.In most of glaucoma people, resistance problem is to execute between Lai Mushi pipe (Schlemm) and the anterior chamber.Occur narrow or when subsiding, can cause the aqueous humor drainage obstacle, thereby intraocular pressure raises, and causes glaucoma when executing Lai Mushi pipe (Schlemm) chamber.
December in 2012 Chinese Patent Office on the 19th discloses the applicant's a patent application, and publication number is: CN102824238A, denomination of invention is: a kind of Lai Mushi pipe (Schlemm) expandable stent and assembly thereof executed.The disclosed expandable stent of this patent application be by tinsel through circumferential skewing repeatedly, axially the formed curve of inflection constitutes, described curve is by coaxial alternate and right-handed screw ring and backpitch ring that put constitute.Such expandable stent has less prepackage diameter and good submissive performance, but structure is comparatively complicated, and manufacture process requirement is higher, and manufacturing cost is slightly high.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of Lai Mushi of executing pipe (Schlemm) expandable stent, this expandable stent, and simple in structure, manufacture process requirement is lower, and manufacturing cost is lower, is conducive to apply.
In order to solve the problems of the technologies described above, the Lai Mushi of executing pipe (Schlemm) expandable stent of the present invention is the one-way spiral shape; The external diameter of described expandable stent adapts with the internal diameter of executing Lai Mushi pipe (Schlemm); The length of described expandable stent adapts with the pipe range of executing Lai Mushi pipe (Schlemm), and perhaps, the length of described expandable stent adapts with the focus length of executing Lai Mushi pipe (Schlemm).
Described expandable stent is a support that is long one-way spiral shape; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is 3 ~ 15mm.
The external diameter of described support is 200um; The length of this support is 40mm; The screw pitch of this support is 10mm.
Described expandable stent is a sub-expandable stent, perhaps, is formed by a plurality of sub-expandable stent serial connections; Each described sub-expandable stent is a submounts that is short one-way spiral shape; The external diameter of this submounts is 150 ~ 250um; The length of this submounts is 1 ~ 6mm; The screw pitch of this submounts is 0.1 ~ 1mm.
The external diameter of this submounts is 200um; The length of this submounts is 3mm; The screw pitch of this submounts is 0.2 ~ 0.5mm.
Described a plurality of sub-expandable stent is integral piece; Perhaps, the two ends of each described sub-expandable stent are provided with expands head or is bent into earhole, and a plurality of described sub-expandable stents form expandable stent by suture by described head or the described earhole serial connection of expanding.
Described sub-expandable stent has 2 ~ 15.
Described sub-expandable stent has 2 ~ 5; The two ends of each described sub-expandable stent are respectively equipped with suture, and the suture of each end is from the close-by examples to those far off passed the axial center hole of all sub-expandable stents of this end successively.
The filament coiling that described expandable stent is made by elastomeric material forms; The diameter of described filament is 20 ~ 100um.
Described elastomeric material is Nitinol, rustless steel 316L or cochrome; The surface of described expandable stent scribbles medicine layer, and described medicine layer comprises fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine.
The present invention compared with prior art has following beneficial effect:
1, the technical program is executed the technological means that Lai Mushi pipe (Schlemm) expandable stent is the one-way spiral shape owing to having adopted, so this expandable stent is simple in structure, manufacture process requirement is lower, and manufacturing cost is lower, is conducive to apply.The schlemm pipe holder of this patent design can be expanded the schlemm tube chamber that subsides lastingly, promotes aqueous humor to flow into collector tube from the schlemm tube chamber of lasting expansion, thereby reduces intraocular pressure, reaches the glaucomatous purpose for the treatment of.
2, the technical program is a support that is long one-way spiral shape owing to having adopted expandable stent; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is the technological means of 3 ~ 15mm, so, can support all sidedly executing Lai Mushi pipe (Schlemm), be applicable to the CR Critical patient treatment of glaucoma.
3, the technical program is 200um owing to having adopted the external diameter of described support; The length of this support is 40mm; The screw pitch of this support is the technological means of 10mm, so, applicable to the CR Critical patient treatment of most of glaucomas.
4, the technical program is the technological means of a sub-expandable stent owing to having adopted expandable stent, so, can carry out the treatment of local lesion to executing Lai Mushi pipe (Schlemm).When the technological means that has adopted a plurality of sub-expandable stents serial connections to form, can treat at executing in the Lai Mushi pipe (Schlemm) a plurality of local lesions.Be a submounts that is short one-way spiral shape owing to having adopted each sub-expandable stent again; The external diameter of submounts is 150 ~ 250um; The length of submounts is 1-6mm; The screw pitch of submounts is the technological means of 0.1 ~ 1mm, so, be applicable to the patient treatment lighter to glaucoma.
5, the technical program is 200um owing to having adopted the external diameter of this submounts; The length of this submounts is 3mm; The screw pitch of this submounts is the technological means of 0.2 ~ 0.5mm, so, applicable to the patient treatment lighter to most of glaucomas.
6, the technical program is integral piece owing to having adopted a plurality of sub-expandable stents, perhaps, the two ends of each sub-expandable stent are provided with expands head or is bent into earhole, a plurality of sub-expandable stents form the technological means of expandable stent by suture by expanding head or earhole serial connection, so, can produce multiple different expandable stent, be applicable to different patient demands.
7, the technical program has been owing to adopted the technological means of 2 ~ 15 sub-expandable stents, so, can satisfy the needs to common glaucoma patient treatment.
8, the technical program is owing to adopted described sub-expandable stent to have 2 ~ 5; The two ends of each sub-expandable stent are respectively equipped with suture, the suture of each end is from the close-by examples to those far off passed the technological means of axial center hole of all sub-expandable stents of this end successively, so, when expandable stent insert execute Lai Mushi pipe (Schlemm) after, be conducive to adjust respectively the position of each sub-expandable stent, its therapeutic effect is better.
9, the technical program is because the filament coiling of having adopted expandable stent to be made by elastomeric material forms, and the diameter of filament is the technological means of 20 ~ 100um, so expandable stent not only has enough elasticity, and has enough rigidity.
10, the technical program is Nitinol owing to having adopted elastomeric material, and the technological means of rustless steel 316L or cochrome is so expandable stent is durable in use.Again owing to adopted the surface of expandable stent to scribble medicine layer, medicine layer comprises the technological means of fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine, so, can prevent support again narrow or endotheliocyte assemble at rack surface.Can expand the schlemm tube chamber that subsides lastingly, promote aqueous humor to flow into collector tube from the schlemm tube chamber of lasting expansion, thereby reduce intraocular pressure, reach the glaucomatous purpose for the treatment of.
Description of drawings
The present invention is made the detailed description in a step below in conjunction with the drawings and specific embodiments.
Fig. 1 is the structural representation that the present invention executes first kind of embodiment of Lai Mushi pipe (Schlemm) expandable stent.
Fig. 2 is the structural representation that the present invention executes second kind of embodiment of Lai Mushi pipe (Schlemm) expandable stent.
Fig. 3 is intended to the improved structure of Lai Mushi pipe (Schlemm) expandable stent of executing among Fig. 2.
Fig. 4 is intended to the another kind of improved structure of Lai Mushi pipe (Schlemm) expandable stent of executing among Fig. 2.
The specific embodiment
The present invention is described in further detail below in conjunction with the drawings and specific embodiments.
As shown in Figure 1, the Lai Mushi of executing pipe (Schlemm) expandable stent 1 of the present invention is the one-way spiral shape; The external diameter of described expandable stent 1 adapts with the internal diameter of executing Lai Mushi pipe (Schlemm); The length of described expandable stent 1 adapts with the pipe range of executing Lai Mushi pipe (Schlemm).
Present embodiment is executed the technological means that Lai Mushi pipe (Schlemm) expandable stent is the one-way spiral shape owing to having adopted, so this expandable stent is simple in structure, manufacture process requirement is lower, and manufacturing cost is lower, is conducive to apply.Again owing to adopted the external diameter of expandable stent and the internal diameter of executing Lai Mushi pipe (Schlemm) to adapt; The technological means that the length of expandable stent and the pipe range of executing Lai Mushi pipe (Schlemm) adapt, so, can support treatment to the total length of executing Lai Mushi pipe (Schlemm).When technological means that the length that has adopted expandable stent and the focus length of executing Lai Mushi pipe (Schlemm) adapt, can support treatment to the part of executing Lai Mushi pipe (Schlemm).
As a kind of improvement of present embodiment, as shown in Figure 1, described expandable stent 1 is a support that is long one-way spiral shape; 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is 3 ~ 15mm.
Present embodiment is a support that is long one-way spiral shape owing to having adopted expandable stent; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is the technological means of 3 ~ 15mm, so, can support all sidedly executing Lai Mushi pipe (Schlemm), be applicable to the CR Critical patient treatment of glaucoma.。
Further improve as present embodiment, the external diameter of described support is 200um; The length of this support is 40mm; The screw pitch of this support is 10mm.
Present embodiment is 200um owing to having adopted the external diameter of support; The length of this support is 40mm; The screw pitch of this support is the technological means of 10mm, so, applicable to the CR Critical patient treatment of most of glaucomas.
As second kind of embodiment, as shown in Figure 2, described expandable stent 1 is a sub-expandable stent 11.Be preferably, the length of sub-expandable stent adapts with the length of executing Lai Mushi pipe (Schlemm) focus.
Present embodiment is the technological means of a sub-expandable stent owing to having adopted expandable stent, so, can carry out the treatment of local lesion to executing Lai Mushi pipe (Schlemm).
As a kind of improvement of present embodiment, as shown in Figure 3, described expandable stent 1 is formed by a plurality of sub-expandable stent 11 serial connections; Each described sub-expandable stent 11 is a submounts that is short one-way spiral shape; The external diameter of this submounts is 150 ~ 250um; The length of this submounts is 1 ~ 6mm; The screw pitch of this submounts is 0.1 ~ 1mm.
Present embodiment is because the technological means that has adopted a plurality of sub-expandable stents serial connections to form, and can treat at executing in the Lai Mushi pipe (Schlemm) a plurality of local lesions.Be a submounts that is short one-way spiral shape owing to having adopted each sub-expandable stent again; The external diameter of support is 150 ~ 250um; The length of submounts is 1-6mm; The screw pitch of submounts is the technological means of 0.1 ~ 1mm, so, be applicable to the patient treatment lighter to glaucoma.
Further improve as present embodiment, the external diameter of described support is 200um; The length of submounts is 3mm; The screw pitch of submounts is 0.2 ~ 0.5mm.
Present embodiment is 200um owing to having adopted the external diameter of support; The length of submounts is 3mm; The screw pitch of submounts is the technological means of 0.2 ~ 0.5mm, so, applicable to the patient treatment lighter to most of glaucomas.
As a kind of improvement of present embodiment, described a plurality of sub-expandable stents 11 are integral piece (referring to Fig. 3); Certainly, also can be respectively equipped with at the two ends of each described sub-expandable stent 11 and expand a 4(referring to Fig. 2 and Fig. 4) or be bent into earhole 3(referring to Fig. 1 and Fig. 3), a plurality of described sub-expandable stents 11 by suture 5 by described expand 4 or described earhole 3 serial connections form expandable stents 1.
Present embodiment is integral piece owing to having adopted a plurality of sub-expandable stents, perhaps, the two ends of each sub-expandable stent are provided with expands head or is bent into earhole, a plurality of sub-expandable stents form the technological means of expandable stent by suture by expanding head or earhole serial connection, so, can produce multiple different expandable stent, be applicable to different patient demands.
Further improve as present embodiment, described sub-expandable stent 11 has 2-15.
Present embodiment has been owing to adopted the technological means of 2-15 sub-expandable stent, so, be applicable to common glaucomatous patient treatment.
Further improve as present embodiment, as shown in Figure 4, described sub-expandable stent 11 has 4 again; The two ends of each described sub-expandable stent 11 are respectively equipped with suture 5, and the suture 5 of each end is from the close-by examples to those far off passed the axial center hole 6 of all sub-expandable stents 11 of this end successively.
Present embodiment is owing to adopted the two ends of each sub-expandable stent to be respectively equipped with suture, the suture of each end is from the close-by examples to those far off passed the technological means of axial center hole of all sub-expandable stents of this end successively, so, be conducive to adjust respectively the position of each sub-expandable stent, its therapeutic effect is better.Certainly, the sub-expandable stent in the present embodiment also can be 2,3 or 5.
Further improve again as present embodiment, the filament coiling that described expandable stent 1 is made by elastomeric material forms; The diameter of described filament is 20 ~ 100um.
Present embodiment is because the filament coiling of having adopted expandable stent to be made by elastomeric material forms, and the diameter of filament is that the diameter of described filament is the technological means of 20 ~ 100um, so expandable stent not only has enough elasticity, and has enough rigidity.
Also further improve as present embodiment, the diameter of described filament is 50um.
Present embodiment is the technological means of 20 ~ 100um owing to having adopted the diameter of filament, so, rigidity the best of expandable stent.
Further improve as present embodiment, described elastomeric material is Nitinol, rustless steel 316L or cochrome.
Present embodiment is Nitinol owing to having adopted elastomeric material, and the technological means of rustless steel 316L or cochrome is so expandable stent is durable in use.Owing to adopted the surface of expandable stent to scribble a kind of special material, comprise fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine again, so, can prevent support again narrow or endotheliocyte assemble at rack surface.
Fluorouracil (5-FU) is the antiproliferative class medicine of using always in the operation for glaucoma with ametycin (MMC), these two kinds of medicines all can prevent endotheliocyte and fibroblast in the gathering of rack surface, thus can prevent from having expanded to execute Lai Mushi pipe (schlemm) tube chamber narrow again.
The rapamycin antiproliferative effect has been widely used in the coating of coronary stent, forms restenosis with Lai Mushi pipe (schlemm) tube chamber of executing that prevents from having expanded.The support that is coated with rapamycin can make restenosis rate lower, can prevent endotheliocyte and fibroblast in the gathering of rack surface, thereby prevents that the Lai Mushi that executes that has expanded manages (schlemm) tube chamber restenosis, can reduce the probability of repeat surgery.
Claims (10)
1. execute Lai Mushi pipe (Schlemm) expandable stent for one kind, it is characterized in that: described expandable stent is the one-way spiral shape; The external diameter of described expandable stent adapts with the internal diameter of executing Lai Mushi pipe (Schlemm); The length of described expandable stent adapts with the pipe range of executing Lai Mushi pipe (Schlemm), and perhaps, the length of described expandable stent adapts with the focus length of executing Lai Mushi pipe (Schlemm).
2. the Lai Mushi that executes according to claim 1 manages (Schlemm) expandable stent, and it is characterized in that: described expandable stent is a support that is long one-way spiral shape; The external diameter of this support is 150 ~ 250um; The length of this support is 38 ~ 45mm; The screw pitch of this support is 3 ~ 15mm.
3. the Lai Mushi that executes according to claim 2 manages (Schlemm) expandable stent, and it is characterized in that: the external diameter of described support is 200um; The length of this support is 40mm; The screw pitch of this support is 10mm.
4. the Lai Mushi that executes according to claim 1 manages (Schlemm) expandable stent, it is characterized in that: described expandable stent is formed by a plurality of sub-expandable stents serial connections; Each described sub-expandable stent is a submounts that is short one-way spiral shape; The external diameter of this submounts is 150 ~ 250um; The length of this submounts is 1 ~ 6mm; The screw pitch of this submounts is 0.1 ~ 1mm.
5. the Lai Mushi that executes according to claim 4 manages (Schlemm) expandable stent, and it is characterized in that: the external diameter of this submounts is 200um; The length of this submounts is 3mm; The screw pitch of this submounts is 0.2 ~ 0.5mm.
6. the Lai Mushi that executes according to claim 4 manages (Schlemm) expandable stent, and it is characterized in that: described a plurality of sub-expandable stents are integral piece; Perhaps, the two ends of each described sub-expandable stent are provided with expands head or is bent into earhole, and a plurality of described sub-expandable stents form expandable stent by suture by described head or the described earhole serial connection of expanding.
7. the Lai Mushi that executes according to claim 6 manages (Schlemm) expandable stent, and it is characterized in that: described sub-expandable stent has 2 ~ 15.
8. the Lai Mushi that executes according to claim 7 manages (Schlemm) expandable stent, and it is characterized in that: described sub-expandable stent has 2 ~ 5; The two ends of each described sub-expandable stent are respectively equipped with suture, and the suture of each end is from the close-by examples to those far off passed the axial center hole of all sub-expandable stents of this end successively.
9. according to described Lai Mushi pipe (Schlemm) expandable stent of executing of one of claim 1 to 8, it is characterized in that: the filament coiling that described expandable stent is made by elastomeric material forms; The diameter of described filament is 20 ~ 100um.
10. the Lai Mushi that executes according to claim 9 manages (Schlemm) expandable stent, and it is characterized in that: described elastomeric material is Nitinol, rustless steel 316L or cochrome; The surface of described expandable stent scribbles medicine layer, and described medicine layer comprises fluorouracil (5-FU), ametycin (MMC) and/or rapamycin antiproliferative class medicine.
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| CN201310191751.1A CN103251479B (en) | 2013-05-22 | 2013-05-22 | Schlemm canal expansion stent |
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| CN201310191751.1A CN103251479B (en) | 2013-05-22 | 2013-05-22 | Schlemm canal expansion stent |
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| CN103251479B CN103251479B (en) | 2014-10-29 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726203A (en) * | 2016-02-04 | 2016-07-06 | 张绍丹 | Schlemm tube probing and flushing support sleeve and use method thereof |
| CN105769433A (en) * | 2016-01-08 | 2016-07-20 | 王素常 | Screw type Schlemm tube stent |
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| US20040193262A1 (en) * | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
| CN101128171A (en) * | 2004-12-16 | 2008-02-20 | I科学干预公司 | Ophthalmic implant for treatment of glaucoma |
| US20120323159A1 (en) * | 2011-06-14 | 2012-12-20 | John Wardle | Ocular Implants for Delivery Into the Eye |
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2013
- 2013-05-22 CN CN201310191751.1A patent/CN103251479B/en not_active Expired - Fee Related
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| CN1208602A (en) * | 1997-08-15 | 1999-02-24 | 沙夫豪森格里斯哈伯股份有限公司 | Method and device to improve aqueous humor drainage in eye |
| US20040193262A1 (en) * | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
| CN101128171A (en) * | 2004-12-16 | 2008-02-20 | I科学干预公司 | Ophthalmic implant for treatment of glaucoma |
| US20120323159A1 (en) * | 2011-06-14 | 2012-12-20 | John Wardle | Ocular Implants for Delivery Into the Eye |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105769433A (en) * | 2016-01-08 | 2016-07-20 | 王素常 | Screw type Schlemm tube stent |
| CN105726203A (en) * | 2016-02-04 | 2016-07-06 | 张绍丹 | Schlemm tube probing and flushing support sleeve and use method thereof |
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|---|---|
| CN103251479B (en) | 2014-10-29 |
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