CN103415322B - Chemically stable anti-dandruff composition for personal care composition - Google Patents
Chemically stable anti-dandruff composition for personal care composition Download PDFInfo
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- CN103415322B CN103415322B CN201180028534.XA CN201180028534A CN103415322B CN 103415322 B CN103415322 B CN 103415322B CN 201180028534 A CN201180028534 A CN 201180028534A CN 103415322 B CN103415322 B CN 103415322B
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- Prior art keywords
- acid
- weight
- zinc
- bedded substance
- dandruff
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- 239000000203 mixture Substances 0.000 title claims abstract description 107
- 239000011701 zinc Substances 0.000 claims abstract description 81
- HCHKCACWOHOZIP-UHFFFAOYSA-N zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 74
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 74
- 239000000126 substance Substances 0.000 claims abstract description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 230000002335 preservative Effects 0.000 claims abstract description 19
- 239000003755 preservative agent Substances 0.000 claims abstract description 19
- 239000003381 stabilizer Substances 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims description 20
- -1 glycol ester Chemical class 0.000 claims description 16
- 239000004094 surface-active agent Substances 0.000 claims description 12
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- BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 9
- 125000000129 anionic group Chemical group 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- UOURRHZRLGCVDA-UHFFFAOYSA-D pentazinc;dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O UOURRHZRLGCVDA-UHFFFAOYSA-D 0.000 claims description 6
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- ZGTMUACCHSMWAC-UHFFFAOYSA-L disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 2
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 2
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- 229940091251 Zinc Supplements Drugs 0.000 description 67
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- 239000002453 shampoo Substances 0.000 description 19
- LILHXQCLSOZSRO-UHFFFAOYSA-J dizinc;oxozinc;dicarbonate;tetrahydrate Chemical compound O.O.O.O.[Zn+2].[Zn+2].[Zn]=O.[Zn]=O.[Zn]=O.[O-]C([O-])=O.[O-]C([O-])=O LILHXQCLSOZSRO-UHFFFAOYSA-J 0.000 description 17
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- 150000001875 compounds Chemical class 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- OTPSWLRZXRHDNX-UHFFFAOYSA-L Zinc pyrithione Chemical compound S1C2=CC=CC=N2=O[Zn]21O=N1=CC=CC=C1S2 OTPSWLRZXRHDNX-UHFFFAOYSA-L 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
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- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 7
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- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N Griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- CTETYYAZBPJBHE-UHFFFAOYSA-N Haloprogin Chemical compound ClC1=CC(Cl)=C(OCC#CI)C=C1Cl CTETYYAZBPJBHE-UHFFFAOYSA-N 0.000 description 1
- FUWUEFKEXZQKKA-UHFFFAOYSA-N Hinokitiol Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N Iodopropynyl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine zwitterion Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- 229950010163 Lanoconazole Drugs 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 229960000282 Metronidazole Drugs 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- VWOIKFDZQQLJBJ-DTQAZKPQSA-N Neticonazole Chemical compound CCCCCOC1=CC=CC=C1\C(=C/SC)N1C=NC=C1 VWOIKFDZQQLJBJ-DTQAZKPQSA-N 0.000 description 1
- 229950010757 Neticonazole Drugs 0.000 description 1
- GHXRKGHKMRZBJH-UHFFFAOYSA-N OB(O)O.OB(O)O Chemical compound OB(O)O.OB(O)O GHXRKGHKMRZBJH-UHFFFAOYSA-N 0.000 description 1
- HJSRRUNWOFLQRG-UHFFFAOYSA-N OC(=O)CC(O)=O.OC(=O)CC(O)=O Chemical compound OC(=O)CC(O)=O.OC(=O)CC(O)=O HJSRRUNWOFLQRG-UHFFFAOYSA-N 0.000 description 1
- JMFOSJNGKJCTMJ-ZHZULCJRSA-N Omoconazole Chemical compound C1=CN=CN1C(/C)=C(C=1C(=CC(Cl)=CC=1)Cl)\OCCOC1=CC=C(Cl)C=C1 JMFOSJNGKJCTMJ-ZHZULCJRSA-N 0.000 description 1
- 229960003104 Ornithine Drugs 0.000 description 1
- 229960002894 Oxiconazole nitrate Drugs 0.000 description 1
- QVLTXCYWHPZMCA-UHFFFAOYSA-N PO4-PO4 Chemical compound OP(O)(O)=O.OP(O)(O)=O QVLTXCYWHPZMCA-UHFFFAOYSA-N 0.000 description 1
- 229940068124 Pine tar Drugs 0.000 description 1
- 229940069338 Potassium Sorbate Drugs 0.000 description 1
- CHHHXKFHOYLYRE-STWYSWDKSA-M Potassium sorbate Chemical compound [K+].C\C=C\C=C\C([O-])=O CHHHXKFHOYLYRE-STWYSWDKSA-M 0.000 description 1
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Quinoform Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 description 1
- CBXWGGFGZDVPNV-UHFFFAOYSA-N SO4-SO4 Chemical compound OS(O)(=O)=O.OS(O)(=O)=O CBXWGGFGZDVPNV-UHFFFAOYSA-N 0.000 description 1
- 240000000203 Salix gracilistyla Species 0.000 description 1
- 210000004761 Scalp Anatomy 0.000 description 1
- 229940082568 Selenium Drugs 0.000 description 1
- 229940091258 Selenium supplements Drugs 0.000 description 1
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- 229910018210 SexSy Inorganic materials 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- 229960003885 Sodium Benzoate Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L Sodium thiosulphate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229960004718 Sulconazole nitrate Drugs 0.000 description 1
- ROBFUDYVXSDBQM-UHFFFAOYSA-N Tartronic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 description 1
- 229940111630 Tea Tree Oil Drugs 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N Terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N Undecylenic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- ORZHVTYKPFFVMG-UHFFFAOYSA-N Xylenol orange Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 ORZHVTYKPFFVMG-UHFFFAOYSA-N 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L Zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- PEHFFJSIXZRLAE-UHFFFAOYSA-J [Zn++].[Zn++].[O-]C([O-])=O.[O-]C([O-])=O Chemical compound [Zn++].[Zn++].[O-]C([O-])=O.[O-]C([O-])=O PEHFFJSIXZRLAE-UHFFFAOYSA-J 0.000 description 1
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- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating Effects 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229940063656 aluminum chloride Drugs 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 230000000843 anti-fungal Effects 0.000 description 1
- 125000004429 atoms Chemical group 0.000 description 1
- 229930015400 berberine Natural products 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 230000000975 bioactive Effects 0.000 description 1
- 230000035514 bioavailability Effects 0.000 description 1
- 235000015386 bitter orange Nutrition 0.000 description 1
- OVYQSRKFHNKIBM-UHFFFAOYSA-N butanedioic acid Chemical compound OC(=O)CCC(O)=O.OC(=O)CCC(O)=O OVYQSRKFHNKIBM-UHFFFAOYSA-N 0.000 description 1
- PNFBLCAFHFTYMT-UHFFFAOYSA-N butylamino formate Chemical class CCCCNOC=O PNFBLCAFHFTYMT-UHFFFAOYSA-N 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- 229960000539 carbamide Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 125000004432 carbon atoms Chemical group C* 0.000 description 1
- HFNQLYDPNAZRCH-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O.OC(O)=O HFNQLYDPNAZRCH-UHFFFAOYSA-N 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 230000005591 charge neutralization Effects 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- 229960005228 clioquinol Drugs 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- SUCKQWWOYOOODR-UHFFFAOYSA-K copper;zinc;carbonate;hydroxide Chemical compound [OH-].[Cu+2].[Zn+2].[O-]C([O-])=O SUCKQWWOYOOODR-UHFFFAOYSA-K 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- YVEWQBBNXXNHKX-UHFFFAOYSA-J dizinc;zinc;dicarbonate;hexahydrate Chemical compound O.O.O.O.O.O.[Zn].[Zn].[Zn].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O YVEWQBBNXXNHKX-UHFFFAOYSA-J 0.000 description 1
- 229960003062 eberconazole Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960001274 fenticonazole Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229960000690 flutrimazole Drugs 0.000 description 1
- 150000004675 formic acid derivatives Chemical class 0.000 description 1
- 229960002867 griseofulvin Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 229960001906 haloprogin Drugs 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 230000001771 impaired Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229960004849 isoconazole Drugs 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000002356 laser light scattering Methods 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-L malate(2-) Chemical compound [O-]C(=O)C(O)CC([O-])=O BJEPYKJPYRNKOW-UHFFFAOYSA-L 0.000 description 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N methanethione Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- 229940113083 morpholine Drugs 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 230000000474 nursing Effects 0.000 description 1
- 230000000414 obstructive Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229960004031 omoconazole Drugs 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- WVNOAGNOIPTWPT-NDUABGMUSA-N oxiconazole nitrate Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)/CN1C=NC=C1 WVNOAGNOIPTWPT-NDUABGMUSA-N 0.000 description 1
- 229960003540 oxyquinoline Drugs 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- ZFACJPAPCXRZMQ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O.OC(=O)C1=CC=CC=C1C(O)=O ZFACJPAPCXRZMQ-UHFFFAOYSA-N 0.000 description 1
- 229910052615 phyllosilicate Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000011297 pine tar Substances 0.000 description 1
- 229920001888 polyacrylic acid Polymers 0.000 description 1
- 150000004291 polyenes Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002829 reduced Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229960005429 sertaconazole Drugs 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 230000003019 stabilising Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 229960005349 sulfur Drugs 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-M thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N tin hydride Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229960004214 tioconazole Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- DQYJMVUCSSPCQV-UHFFFAOYSA-H trizinc;dicarbonate;dihydroxide Chemical compound [OH-].[OH-].[Zn+2].[Zn+2].[Zn+2].[O-]C([O-])=O.[O-]C([O-])=O DQYJMVUCSSPCQV-UHFFFAOYSA-H 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000003878 whitfield ointment Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- MQWLIFWNJWLDCI-UHFFFAOYSA-L zinc;carbonate;hydrate Chemical compound O.[Zn+2].[O-]C([O-])=O MQWLIFWNJWLDCI-UHFFFAOYSA-L 0.000 description 1
- KOSIBOSSOGMXIG-UHFFFAOYSA-L zinc;oxido hydrogen carbonate Chemical compound [Zn+2].OC(=O)O[O-].OC(=O)O[O-] KOSIBOSSOGMXIG-UHFFFAOYSA-L 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Abstract
The present invention relates to stable anti-dandruff composition, described compositions comprises the insoluble anti-dandruff agent of about 10 weight % to about 40 weight %, the stabilizer of about 6 weight % to about 12 weight %, the preservative of less than about 1 weight %, the nertralizer of about 0.5 weight % to about 1 weight %, and water.In one embodiment of the invention, it relates to a kind of stable anti-dandruff composition, described compositions comprise about 10 weight % to about 25 weight % containing zinc bedded substance, the stabilizer of about 6 weight % to about 12 weight %, the less than about preservative of 1 weight %, the nertralizer of about 0.5 weight % to about 1 weight %, and water.
Description
Cross-Reference to Related Applications
The rights and interests of the U.S. Provisional Application 61/353005 of patent application claims submission on June 9th, 2010.
Invention field
The disclosure relates generally to the preparation of the composition being frequently utilized in Shampoo preparation, and relates more specifically to mix
Dandruff chemically stable, insoluble in personal care composition and/or antimicrobial compositions.
Background technology
The personal care composition of such as shampoo comprises anti-dandruff agent (or granule) sometimes.When being present in these combinations
Time in thing, anti-dandruff agent is typically based on the gross weight meter amount with about 0.01 weight % to about 5 weight % of personal care composition
It is included.In these compositionss, anti-dandruff particles with other component physics and chemical compatibility of compositions, and should or not
Destroy the stability of product, aesthetic property or performance undeservedly.
The anti-dandruff agent being applicable to personal care composition includes pyrithione, azoles (azoles) (such as, ketone health
Azoles, econazole and Xin Kang azoles), selenium sulfide, granulated sulfur, salicylic acid, and their mixture.Typical anti-dandruff agent is
Pyrithione.Personal care composition also is able to include containing zinc bedded substance.An example containing zinc bedded substance can wrap
Include zinc carbonate material.In these materials, zinc carbonate and pyrithione (especially Zinc Pyrithione or " ZPT ") are common in group
In compound, and exist the most together.These and other anti-dandruff agent is being described more particularly below.
ZPT is incorporated into usually used as serosity in the batch methods manufacturing shampoo Compositions.Serosity generally comprises about 25-50
The ZPT of weight % and the surfactant of less than about 1 weight %, surplus is water.Serosity by continuous mechanical agitation to maintain stability.
In the case of there is not stirring, ZPT can be contemplated and be separated from water within a few hours (such as, four hours).At this serosity
In the case of inhomogeneous, ZPT will be distributed in shampoo unevenly, and therefore final product composition having is for regulation performance and quality
Viewpoint and impaired.
Zinc carbonate is introduced in usually used as dry matter in the batch methods manufacturing shampoo Compositions.Specifically,
Zinc carbonate is introduced in one or more anionic detersive surfactants and water usually used as dry powder.Surfactant afterwards
Mix to form finished product shampoo with other composition with water.Zinc carbonate is introduced in anionic detersive surface by conventional equipment and lives
In property agent and/or water, described device is suitable to be incorporated in liquid the powder being difficult to moistening, such as by Quadro
Those of Engineering (Ontario, Canada) business manufacture.
The preparation using the shampoo Compositions of these anti-dandruff agents is bad under being stirred by mechanical to a certain extent
Material stability (in the case of ZPT) and the obstruction of difficulty (in the case of zinc carbonate) that processes.Additionally, about zinc carbonate,
This material is most frequently by mixing with one or more main components in preparation (i.e. water and/or anionic detersive surfactant)
Close and be incorporated in Shampoo preparation.Once mixing with specific examples of such components, the most described composition is restricted to for as dandruff
In the preparation of personal care composition.Due to the difficulty processed and effectively dispersion is difficult to wetting powder, shampoo Compositions does not has
Having other composition is the carrier for the equal facility being incorporated in shampoo Compositions by zinc carbonate.Therefore, it is not required to when expectation
When wanting the Shampoo preparation of dandruff character, it is necessary to prepare a collection of new composition.
According to noted earlier, it is desirable to the anti-dandruff composition of offer provides more effective and reliable stability, more effectively
Manufacture, and incorporate them into the more flexible property in personal care composition.
Summary of the invention
In one embodiment of the invention, stable anti-dandruff composition includes that about 10 weight % are to about 40 weight %
Insoluble anti-dandruff agent, the stabilizer of about 6 weight % to about 12 weight %, the preservative of less than about 1 weight %, and about 0.5 weight
The nertralizer of amount % to about 1 weight %, and water.In another embodiment of the present invention, stable anti-dandruff composition bag
Containing about 10 weight % to about 25 weight % containing zinc bedded substance, the stabilizer of about 6 weight % to about 12 weight %, less than about 1 weight %
Preservative, and about 0.5 weight % is to the nertralizer of about 1 weight %, and water.
Summary of drawings
Particularly point out and be distinctly claimed, although providing after description, the power being considered subject of the present invention
Profit claim, it is believed that, by description below in conjunction with the accompanying drawings, the present invention being may be better understood, described accompanying drawing depicts
For the method producing the dispersion comprising zinc bedded substance, water and decontamination anion surfactant.In order to the most aobvious
Showing other element, this figure is simplified by the element selected by omission.In any exemplary, except accordingly
Explanatory note book in be expressly recited outside, in this figure, this type of of element omits the existence or not necessarily meaning that particular element
Exist.This figure is not necessarily drawn to scale.
Detailed Description Of The Invention
Have now found that ZPT, zinc carbonate and other anti-dandruff agent can not only be more convenient and be efficiently introduced into for making
Make in the batch processes of shampoo Compositions, and can be incorporated in continuation method.Have been found that ZPT and other anti-dandruff agent
Can when than the bigger concentration imagined up to now chemically stable (relative mechanical is stable) at room temperature.Additionally, it is chemically stable
Material preferably will separate with its carrier, and therefore, heterogeneity is not significant risk.Similarly, it has been found that such as zinc carbonate
Zinc bedded substance can under bigger concentration (that is, the carrier fluid amount of minimizing) chemically stable, and be incorporated into shampoo Compositions
In manufacturing continuously.More particularly, zinc bedded substance generally the most described material is with in the groove of the active matter quality existence of 5%
Preparation；But, it now is possible to prepared by the active matter quality of 30%.
According to an aspect, stable anti-dandruff composition will include that about 15 weight % are gone to about 22 the insoluble of weight %
Dandruff agent, the stabilizer of about 6 weight % to about 12 weight %, the preservative of less than about 1 weight %, and about 0.5 weight % is to about 1
The nertralizer of weight %, surplus is water.In another embodiment of the present invention, stable anti-dandruff composition will include
The insoluble anti-dandruff agent of about 20 weight %, the stabilizer of about 10 weight %, the preservative of less than about 1 weight %, and about 0.5
Weight % is to the nertralizer of about 1 weight %, and surplus is water.These compositions can at room temperature mix in agitator tank.Dandruff
The more detailed description of agent and stabilizer is shown below.
According to another aspect, the stable shape composition of matter containing zinc layers will include about 10 weight % to about 25 weight %, about 6
Weight % is to the stabilizer of about 12 weight %, the preservative of less than about 1 weight %, and about 0.5 weight % is to the neutralization of about 1 weight %
Agent, surplus is water or is one or more the identical anionic detersive surfactants that can supply finished product shampoo Compositions.
In another embodiment of the present invention, the stable shape composition of matter containing zinc layers will include that about 12 weight % are to about 20 weight %
Containing zinc bedded substance, the stabilizer of about 10 weight %, the preservative of less than about 1 weight %, and about 0.5 weight % is to about 1 weight
The nertralizer of amount %, surplus is water or is one or more the identical anionic detersive tables that can supply finished product shampoo Compositions
Face activating agent.In one embodiment of the invention, it is basic zinc carbonate containing zinc bedded substance.Containing zinc bedded substance with stable
The more detailed description of agent is shown below.
Stable can be prepared by blending constituent in agitator tank containing zinc layers shape composition of matter.Alternatively
Select, it has been found that described compositions can advantageously be prepared according to the method for type shown in unique accompanying drawing.Described method one
As include being incorporated in mixing channel one or more anionic detersive surfactants and water by dip tub A.At mixing channel
In be enough to ensure that good homogenizing without cause aeration speed (such as, for 40rpm in the bilobed wheel septalium of 130L
To 50rpm) stir surfactant and water.By charge door B by preservative (such as, gross weight meter based on described compositions
The sodium benzoate of at least about 0.25 weight %, the methylchloroisothiazandnone of about 5ppm to about 15ppmOr it
Mixture) and acid (such as, gross weight meter about 0.5 weight % based on described compositions to the 6N HCl of about 1.0 weight %)
Join in mixing channel and stir (such as, being 40rpm to 50rpm in the bilobed wheel septalium of 130L).Interior in mixing channel
Tolerant pumping is laid equal stress on back mixing groove by being suitable to be dispersed into powder the device of liquid.This is referred to as recirculation circuit.Zinc layers shape
A part for material is added on each path (such as, the zinc bedded substance of about 5 weight % and about 95 weights via powder hopper C
The instantaneous ratio of the carrier fluid of amount %) and pump by mixing facilities, it mixes with the recirculation content in mixing channel in the device
Close.The recirculation of mixing channel content proceeds, and wherein adds other zinc bedded substance during circulation every time, until institute
Some zinc bedded substances are impregnated in.The number of times that recirculation occurs depends on joining the initial of the zinc bedded substance in system
Amount.Zinc bedded substance is with an embodiment of the instantaneous weight ratio about 5 to about 95 of carrier fluid wherein, needs to follow for about six times
Ring is with the serosity reaching 30%.After all zn bedded substance is impregnated in, by dip tub A by suspending agent (such as, about 10
The EGDS crystallized out by surfactant solution of weight %) join in mixing channel with stabilising dispersions.Stable dispersion with
Rear being pumped is left mixing channel and enters storage tank.
Stable anti-dandruff composition and stable zinc carbonate compositions can be incorporated into its of shampoo Compositions
It was combined into single pre-composition before in its composition.But, for continuation method it may be desirable to keep each at single container
In with allow degree of freedom bigger in preparing different shampoo Compositions and without heavy switch process.
I. anti-dandruff agent
A. pyrithione
Pyridinethione anti-dandruff granule, especially pyrithione salt are suitable granular anti-dandruff agent.
Content gross weight based on the personal care product meter of Pyridinethione anti-dandruff granule generally in about 0.01 weight % to about 5 weights
Amount %, the most about 0.1 weight % to about 3 weight %, in the range of the most about 0.1 weight % to about 2 weight %.Suitable pyrithione
Salt includes those formed by heavy metal, described heavy metal such as zinc, stannum, cadmium, magnesium, aluminum and zirconium, generally zinc, usually 1-hydroxyl
The zinc salt (being known as " Zinc Pyrithione " or " ZPT ") of base-pyrithione, the usually from 1-hydroxyl-2-of flaky particle form
Pyrithione, wherein said granule has at most about 20 μm, the most about 5 μm, the average chi of the most at most about 2.5 μm
Very little.It is suitable that the salt formed by other cation such as sodium ion is alternatively.Pyridinethione anti-dandruff agent is described in the such as U.S.
Patent No.2,809,971；United States Patent (USP) No.3,236,733；United States Patent (USP) No.3,753,196；United States Patent (USP) No.3,761,
418；United States Patent (USP) No.4,345,080；United States Patent (USP) No.4,323,683；United States Patent (USP) No.4,379,753；And United States Patent (USP)
In No.4,470,982.As noted above, ZPT is preferred pyrithione.
It is also conceivable that when the antimicrobial particle that ZPT is used as in antimicrobial personal care composition, can stimulate
Or regulate (or stimulate simultaneously and regulate) hair growth or the additional beneficial effect of regeneration, or can reduce or suppress hair to damage
Lose, or hair can seem denser or more plentiful.
Such as United States Patent (USP) 2, illustrated in 809,971, by making pyrithione (i.e. pyrithione
Acid) or its soluble-salt and zinc salt (such as zinc sulfate) be reacted to form zinc pyrithione precipitate, Zinc Pyrithione can be prepared.
B. anti-microbial active matter
In addition to anti-dandruff active, shampoo Compositions may also comprise one or more except mercaptopyridine thioketone
Antifungal outside slaine or anti-microbial active matter.Suitable anti-microbial active matter includes coal tar, sulfur, wood
Charcoal, U.S.A reach whitfield ointment, Castellani's Paint, aluminum chloride, Gentian Violet, Octopirox (piroctone amine), ring
Pyrrone amine, 9-undecylenic acid and slaine thereof, potassium permanganate, selenium sulfide, sodium thiosulfate, propylene glycol, bitter orange oil, carbamide system
Agent, griseofulvin, 8-hydroxyquinoline clioquinol, thiobendazole, thiocarbamate, haloprogin, polyene, hydroxyl pyrrole
Pyridine ketone, morpholine, benzylamine, allylamine (such as terbinafine), tea tree oil, Folium Caryophylli oil, coriander, Cymbopogon martini, berberine, Herba thymi vulgaris
Red, Oleum Cinnamomi, cinnamic aldehyde, citronellic acid, hinokitol, ichthyol are white, Sensiva SC-50, Elestab HP-100, Azelaic Acid,
Lyase, iodo propinyl butylamino formates (IPBC), isothiazolone such as octylisothiazolinone and azole, and they
Combination.Typical antimicrobial includes itraconazole, ketoconazole, selenium sulfide and coal tar.
I. pyrrole
Azoles antimicrobial includes imidazoles such as benzimidazole, benzothiazole, bifonazole, butunazole nitrate, Gan Bao
Element, clotrimazole, Crewe health azoles, eberconazole, econazole, new health azoles, fenticonazole, fluconazol, flutrimazole, isoconazole, ketone health
Azoles, lanoconazole, metronidazole, miconazole, neticonazole, omoconazole, oxiconazole nitrate, Sertaconazole, sulconazole nitrate,
Tioconazole, thiazole and triazole such as terconazole (triaconazole) and itraconazole, and combinations thereof.When present in the composition, azoles resists micro-
Bioactive substance gross weight based on described personal care product meter is with about 0.01 weight % to about 5 weight %, normally about 0.1 weight
Measure % to about 3 weight %, and the content of the most about 0.3 weight % to about 2 weight % is included.The most usually can be used for herein be
Ketoconazole.
Ii. selenium sulfide
Selenium sulfide is the granular anti-dandruff agent being applicable to antimicrobial personal care composition, and its valid density is based on institute
Stating the gross weight meter of personal care product in about 0.1 weight % to about 4 weight %, normally about 0.3 weight % is to about 2.5 weight %, often
Often in the range of about 0.5 weight % to about 1.5 weight %.Selenium sulfide is generally considered to be has a mol selenium and the change of two molar sulphur
Compound, although it alternatively meets the circulus of formula SexSy, wherein x+y=8.As by forward laser light scattering device (example
Such as Malvern3600 instrument) measured by, the mean diameter of selenium sulfide is typically smaller than 15 μm, typically less than 10 μm.Selenium sulfide
Compound is described in such as United States Patent (USP) 2,694,668；United States Patent (USP) 3,152,046；United States Patent (USP) 4,089,945；And the U.S.
In patent 4,885,107.
Iii. sulfur
Sulfur also is used as the particulate anti-microbial/anti-dandruff agent in antimicrobial personal care composition.Drop sulfur
The valid density of sulphur gross weight based on described personal care product meter is typically about 1 weight % to about 4 weight %, normally about 2 weights
Amount % to about 4 weight %.
Iv. keratolytic agent
In some embodiments, personal care composition also is able to include one or more keratolytic agents such as bigcatkin willow
Acid.
Personal care composition may also comprise the combination of anti-microbial active matter.This type of combination can include Octopirox
The combination of combination, salicylic acid and Zinc Pyrithione, salicylic acid and the group of Xin Kang azoles with Zinc Pyrithione, pine tar and sulfur
Conjunction, Zinc Pyrithione and the group of the combination of the combination of Xin Kang azoles, Octopirox and climbazole, salicylic acid and Octopirox
Close, and their mixture.
II. the zinc-containing substance of zinc carbonate is included
Personal care composition can include containing zinc bedded substance.Those compositionss can include based on described personal nursing
Gross weight meter about 0.001 weight % of compositions to about 10 weight % containing zinc bedded substance.In one embodiment of the invention
In, personal care composition can include that gross weight meter about 0.01 weight % based on described personal care composition is to about 7 weights
Amount % containing zinc bedded substance.In another embodiment of the present invention, personal care composition can include based on described
Gross weight meter about 0.1 weight % of people's care composition to about 5 weight % containing zinc bedded substance.Suitable containing zinc bedded substance bag
Include following those, including zinc carbonate material, it is currently preferred.
The layer structure containing zinc is those that crystal mainly grows on two dimensional surface.Conventionally layer structure is described as it
In the most all atoms be all incorporated in clear and definite layer, and wherein interlayer exist be referred to as tunnel ion (A.F.Wells's
" Structural Inorganic Chemistry ", Clarendon Press, 1975) those of lewis' acid.Containing zinc
Bedded substance (ZLM) can have the zinc being incorporated in layer and/or can be tunnel ion component.
Many ZLM occur with the form of mineral at nature.Common embodiment includes marionite (zinc carbonate hydroxide
Thing), basic zinc carbonate, aurichalcite (zinc copper carbonate hydroxide), rosasite (curpic carbonate zinc hydroxide) and
Many associated minerals containing zinc.Natural ZLM also can exist, wherein anion bedded substance such as clay-type minerals (such as phyllosilicate)
Comprise the zinc tunnel ion of ion exchange.All these natural materials also can be obtained by synthesis, or in the composition or giving birth to
It is formed in situ during product process.
The another kind of common type ZLM the most always prepared by synthesis is layered double-hydroxide, and it is generally by changing
Formula [M2+ 1-xM3+ x(OH)2]x+Am- x/m.nH2O represents, and part or all of divalent ion (M2+) represent zinc ion
(Crepaldi, E L, Pava, P C, Tronto, J, Valim, J B, J.Colloid Interfac.Sci.2002,248,
429-42)。
Also can prepare another kind of be referred to as hydroxy double salts ZLM (Morioka, H., Tagaya, H., Karasu, M,
Kadokawa, J, Chiba, K, " Inorg.Chem. ", 1999,38,4211-6).Hydroxy double salts can be by formula [M2+ 1-xM2+ 1+x
(OH)3(1-y)]+An- (1-3y)/n.nH2O represents, two of which metal ion can be different；If they are identical and are represented by zinc, then change
Formula is reduced to [Zn1+x(OH)2]2x+2xA-.nH2O.This latter's chemical formula represents such as hydroxy chloride zinc and alkali formula zinc nitrate
Common materials (wherein x=0.4).These are directed to marionite, and wherein dianion instead of univalent anion.These materials
Also can in the composition or in process of production or be formed in situ during production process.
The ZLM of these classifications represents in total classification embodiment more typically and is not intended to wider is met this
The material of definition restricts.
The source of commercially available basic zinc carbonate include Zinc Carbonate Basic (CaterChemicals:
Bensenville,Ill.,USA)、Zinc Carbonate(Shepherd Chemicals:Norwood,Ohio,USA)、
Zinc Carbonate(CPS Union Corp.:New York,N.Y.,USA)、Zinc Carbonate(Elementis
Pigments:Durham, UK) and Zinc CarbonateAC (Bruggemann Chemical:Newtown Square, Pa.,
USA)。
Basic zinc carbonate, commercial is also called " zinc carbonate " or " zinc carbonate alkali " or " zinc hydroxycarbonate ", for synthesis system
Type, is made up of the material similar with naturally occurring marionite.Preferably stoichiometry is represented by Zn5(OH)6(CO3)2,
But actual stoichiometric proportion can be slightly different, and can be mixed with other impurity in lattice.
By by anti-dandruff agent and effective dose containing zinc layers shape combinations of substances, it is possible to dramatically increase in topical compositions
Anti-dandruff efficacy, the wherein said bedded substance containing zinc has specific zinc unstability in surfactant system.Zinc
Unstability is that zinc ion is chemically active to be measured.Not compound with other material in solution solvable zinc salt has defined
The relative zinc unstability of 100%.Use can be partly dissolved the zinc salt of form and/or be incorporated into the substrate with potential complexant
In, it will usually reduce zinc unstability, be substantially less than 100% maximum of definition.
Effectively can protect containing zinc bedded substance by selecting effectively to contain zinc bedded substance or pass through known method in-situ generation
Hold the zinc providing unstable.
By the multivalent metal salt of pyrithione such as Zinc Pyrithione is used with containing zinc layers shape combination of materials, energy
Enough dramatically increase the anti-dandruff efficacy in topical compositions.Therefore, personal care composition can include for locally executing
With and comprise simultaneously anti-dandruff agent with containing those of zinc bedded substance, to provide, to skin and scalp, the beneficial effect improved
(such as, the anti-dandruff efficacy of improvement).
Being especially preferred for use in the stable compositions containing zinc layered material dispersion, wherein zinc source exists in granular form.Existing
It has been shown that it is challenging that preparation comprises the Aquo System containing zinc bedded substance, this is unique containing zinc bedded substance due to
Physics and chemical property.High density (about 3g/cm can be had containing zinc bedded substance3), and need to be dispersed in whole product
In product, thus it will not be assembled or settle.Containing zinc bedded substance, also there is the most active surface chemical property, and be dissolved in
PH value is less than the tendency in the system of 6.5.The dissolubility bedded substance containing zinc less than 25% has the measured dissolving less than threshold value
Zinc value %.Described threshold value is determined by percetage by weight and the molecular weight of zinc compound.Following equation can be passed through, calculate theoretical threshold
Value: 0.25 is multiplied by weight % of zinc compound in compositions is multiplied by the molal quantity of zinc in compound and is multiplied by the 65.39 (molecules of zinc
Amount) molecular weight of/zinc compound.PH can be greater than about 6.5；In another embodiment, pH can be in the scope of about 6.5 to about 12
In.In another embodiment of the present invention, pH can be about 6.8 to about 9.5.In another embodiment of the present invention,
PH can be about 6.8 to about 8.5.
Smaller particle size is inversely proportional to relative zinc unstability.D (90) is that the granule of 90% amount is corresponding less than this size
Granularity.Following particle size distribution can be had: wherein the granule of 90% is less than about 50 microns, and wherein the granule of 90% is little containing zinc bedded substance
In about 30 microns, wherein the granule of 90% is less than about 20 microns.
Direct relation can be there is between surface area and relative zinc unstability.Due to kinetic factor, granule surface area
Increase and typically can increase zinc unstability.By reducing particle diameter and/or changing particle shape to produce porous particle or geometry
Its overall shape upper deviates spherical granule increases the surface area of granule.
Basic zinc carbonate can have greater than about 10m2/ g, greater than about 20m2/ g, or greater than about 30m2The surface area of/g.
The stable shape composition of matter containing zinc layers may also include coordination compound, and it has and be enough to keep zinc bioavailability
In the range of Log Zn binding constant.In one embodiment of the invention, this type of coordination compound has less than about 6
Log Zn binding constant.In another embodiment of the present invention, this type of coordination compound has the Log Zn knot of less than about 5
Close constant.In another embodiment of the present invention, this type of coordination compound has less than about 4 and the Log of greater than about-0.5
Zn binding constant.In one embodiment of the invention, this type of coordination compound is organic acid, strong inorganic acid or coordination thing.
The preferred embodiment of above-mentioned coordination compound includes these (corresponding Log Zn binding constant is shown in bracket): EDTA following
(16.5), EDDS (13.5), EDDA (11.1), NTA (10.7), xylenol orange (10.3), cysteine (9.1), cystine
(6.7), aspartic acid (aspartate) (5.9), glycine (5.0), citric acid (citrate) (4.8), glutamic acid
(4.5), methionine (4.4), arginine (4.2), carbonic acid (carbonate) (3.9), ornithine (3.8), tartaric acid (tartaric acid
Salt) (3.2), malic acid (malate) (2.9), malonic acid (malonate) (2.9), tartaric acid (tartrate) (2.7), oneself
Diacid (adipate) (2.6), phosphoric acid (phosphate) (2.4), phthalic acid (phthalate) (2.2), glycolic (second
Alcohol hydrochlorate) (2.0), lactic acid (lactate) (1.9), succinic acid (succinate) (1.8), acetic acid (acetate) (1.0), sulphuric acid
(sulfate) (0.9), boric acid (borate) (0.9), formic acid (formates) (0.6), chloride (-0.3).
Have containing zinc bedded substance and pyrithione or the embodiment party of pyrithione multivalent metal salt
In case, the ratio containing zinc bedded substance with pyrithione or pyrithione multivalent metal salt is 5:100 to 10:
1.Have containing zinc bedded substance and pyrithione or the embodiment party of the present invention of pyrithione multivalent metal salt
In another embodiment of case, containing zinc bedded substance and pyrithione or pyrithione multivalent metal salt
Ratio is about 2:10 to 5:1.Have containing zinc bedded substance and pyrithione or pyrithione polyvalent metal
In another embodiment of salt, containing zinc bedded substance and pyrithione or pyrithione multivalent metal salt
Ratio is 1:2 to 3:1.
III. stabilizer
The propylene of crosslinking is included for stable anti-dandruff composition or the suitable stabilizer containing zinc layers shape composition of matter
Acid polymer, trihydroxy tristerin and the glycol ester of fatty acid.In one embodiment of the invention, crosslinking
Acrylate copolymer be those with CTFA title carbomer.In another embodiment of the present invention, fatty acid
Glycol ester has about 16 to about 22 carbon atoms.In another embodiment of the present invention, stabilizer is that ethylene glycol is stearic
Acid esters, including monostearate and distearate, but is especially the two hard of the monostearate comprising less than about 7%
Fat acid ester.
IV. preservative
Preservative can be for when being exposed to the pH scope that compositions is intended to be saved or at the bar manufactured for compositions
Any preservative not reacted under part or degrade.The limiting examples of preservative include sodium benzoate, benzylalcohol, potassium sorbate,
Disodiumedetate (Na2EDTA), tetrasodium ethylenediamine tetraacetate (Na4And their mixture EDTA),.Preservative energy
Enough to effectively kill or to suppress any amount of growth of microorganism to exist.Preservative consumption depends on the concrete anticorrosion used
Agent.Such as, preservative can include the sodium benzoate of gross weight meter about 0.25 weight % based on described compositions, about 5ppm extremely
The methylchloroisothiazandnone of about 15ppmOr their mixture.
V. nertralizer
The limiting examples of nertralizer includes hydrochloric acid, citric acid, aspartic acid, glutamic acid, carbonic acid, hydroxymalonic acid, Herba Marsileae Quadrifoliae
Fruit acid, malonic acid, tartaric acid, adipic acid, phosphoric acid, phthalic acid, glycolic, lactic acid, succinic acid, acetic acid, sulphuric acid, boric acid,
Formic acid, and their mixture.Acid as the component in shampoo formulations with the holding causing being suitable to compositions and use
Any amount of pH exists.Such as, the 6N HCl of about 0.5 weight % to about 1.0 weight % can be included in stable dandruff group
In compound and be also included within stable containing in zinc layers shape composition of matter.
Dimension disclosed herein and value are not intended to be understood to be limited strictly to described exact value.On the contrary, unless separately
Indicating outward, each such dimension is intended to represent described value and around the functionally equivalent scope of this value.Such as, disclosed
Size " 40mm " be intended to indicate that " about 40mm ".
Unless expressly excluded or otherwise limited, every document cited herein, including any intersection
That quote or relevant patent or patent application, be incorporated by herein the most hereby.Quoting of any document is not
To it as the prior art of disclosed herein or claimed any invention, or its individually or with
Any combination of other list of references any, or with reference to, propose, advise or disclose any this type of invent accreditation.Additionally, work as
Any implication of term or definition and any implication of term in the file that is incorporated by reference or definition contradiction in the present invention
Time, it should obey implication or the definition giving this term in the present invention.
Although illustrate and describing the present invention by specific embodiments, but those skilled in the art are shown
And be clear to, can make without departing from the spirit and scope of the present invention many other change and amendment.Therefore,
The all these changes being intended in following claims in the scope of the invention and modification.
Claims (7)
1. the method preparing anti-dandruff composition, comprising:
A) one or more anionic detersive surfactants, water or their mixture being blended in mixing channel；
B) in described mixing channel with conventional rate stirring one or more anionic detersive surfactants described, water or it
Mixture to provide homogenizing；
C) preservative and one or more acid joined in described mixing channel and stir to provide homogenizing with conventional rate；
D) content of described mixing channel is pumped by device, so that the part containing zinc bedded substance is divided via powder hopper
It is dispersed on each path；
E) content of mixing channel described in recirculation adding containing zinc bedded substance until containing described in Quan Bu during every time circulation
Zinc bedded substance is incorporated in the content of described mixing channel；
F) stabilizer is joined in described mixing channel；And
Wherein said anti-dandruff composition comprise 10 weight % to 25 weight % containing zinc bedded substance, 6 weight % to 12 weights
The stabilizer of amount %, less than the preservative of 1 weight % and the acid of 0.5 weight % to 1 weight %, and water, and described stabilizer
Acrylate copolymer, trihydroxy tristerin, the glycol ester of fatty acid and mixture thereof selected from crosslinking.
2. the method for claim 1, wherein said device is recirculation circuit.
3. the method for claim 1, wherein said is basic zinc carbonate containing zinc bedded substance.
4. the method for claim 1, wherein said anti-dandruff composition comprises 12 weight % containing to 20 weight %
Zinc bedded substance.
5. the method for claim 1, wherein said stabilizer is ethylene glycol stearate.
6. the method for claim 1, wherein said preservative selected from sodium benzoate, benzylalcohol, disodiumedetate,
Tetrasodium ethylenediamine tetraacetate, methylchloroisothiazandnone and their mixture.
7. the method for claim 1, wherein said acid selected from hydrochloric acid, citric acid, aspartic acid, glutamic acid, carbonic acid, third
Alcohol diacid, malic acid, malonic acid, tartaric acid, adipic acid, phosphoric acid, phthalic acid, glycolic, lactic acid, succinic acid, acetic acid, sulfur
Acid, boric acid, formic acid, and their mixture.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35300510P | 2010-06-09 | 2010-06-09 | |
| US61/353,005 | 2010-06-09 | ||
| PCT/US2011/039746 WO2011156566A2 (en) | 2010-06-09 | 2011-06-09 | Chemically stabilized anti-dandruff compositions for use in personal care compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103415322A CN103415322A (en) | 2013-11-27 |
| CN103415322B true CN103415322B (en) | 2016-12-14 |
Family
ID=
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0108517A2 (en) * | 1982-10-13 | 1984-05-16 | The Procter & Gamble Company | Process for making shampoo compositions |
| CN1037271A (en) * | 1988-04-28 | 1989-11-22 | 普罗格特-甘布尔公司 | Stable dandruff shampoo Compositions |
| EP0200305B1 (en) * | 1985-02-28 | 1991-03-27 | The Procter & Gamble Company | Anti-dandruff shampoos |
| US5104645A (en) * | 1990-02-02 | 1992-04-14 | The Proctor & Gamble Company | Antidandruff shampoo compositions |
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0108517A2 (en) * | 1982-10-13 | 1984-05-16 | The Procter & Gamble Company | Process for making shampoo compositions |
| EP0200305B1 (en) * | 1985-02-28 | 1991-03-27 | The Procter & Gamble Company | Anti-dandruff shampoos |
| CN1037271A (en) * | 1988-04-28 | 1989-11-22 | 普罗格特-甘布尔公司 | Stable dandruff shampoo Compositions |
| US5104645A (en) * | 1990-02-02 | 1992-04-14 | The Proctor & Gamble Company | Antidandruff shampoo compositions |
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