CN103446673A - Epilepsy treatment system - Google Patents
Epilepsy treatment system Download PDFInfo
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- CN103446673A CN103446673A CN2013104096850A CN201310409685A CN103446673A CN 103446673 A CN103446673 A CN 103446673A CN 2013104096850 A CN2013104096850 A CN 2013104096850A CN 201310409685 A CN201310409685 A CN 201310409685A CN 103446673 A CN103446673 A CN 103446673A
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Abstract
The invention relates to an epilepsy treatment system which comprises a data collection device, a central processing unit and a stimulation device. The data collection device is used for collecting changes of accelerated speed of body movement of a patient in real time and transmitting the changes of the accelerated speed to the central processing unit. The central processing unit is used for analyzing the changes of the accelerated speed in real time; a threshold value of the changes of the accelerated speed is preset in the central processing unit. The stimulation device is used for applying a stimulation signal to carry out stimulation treatment on the patient, wherein the stimulation signal is at least one of an optical signal and an electric signal. When the changes of the accelerated speed reach the preset threshold value, the central processing unit controls the stimulation device to apply the stimulation signal to carry out stimulation treatment on the patient. The epilepsy treatment system can treat epileptics in real time and has the advantages of being good in treatment effect and few in sequelae.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly relate to a kind of epilepsy therapy system.
Background technology
Epilepsy (Epilepsy) is the of short duration handicapped a kind of chronic disease of brain that the electric discharge of cerebral neuron paroxysmal abnormality causes.The latest data provided according to the World Health Organization (WHO), current global epileptic's quantity has accounted for 1% of total population, and wherein China has nearly 10,000,000.Because epilepsy is comparatively frequent and have unpredictability, not only have a strong impact on patient's daily life, study and work, even may threat to life, bring great pressure to patient, family and society.
The primary treatment method of epilepsy is to prevent that with antiepileptic the clinical episodes of epilepsy, its mechanism of action from being mainly the inhibition to the neuron ion channel.Although traditional Antiepileptic Drugs has certain therapeutic effect to many patients, long-term taking often is accompanied by the infringement (as memory and attention deficit etc.) of cognitive function and other central nervous system's side effect (as psychomotor velocity anomaly, drowsiness, weak and dizzy etc.).Even so, still have in the world the patient of 30% left and right insensitive to Drug therapy.What for this part patient, mainly adopt is destructive therapy, as excision or the damage of local brain tissue.Although surgical operation can part be controlled epilepsy effectively, but because its wound is large, normal with serious complication, and people extremely limit to brain and neural understanding at present, careless slightlyly just may cause unpredictable consequence, these present situations make operating clinical practice be very limited.
Summary of the invention
Based on this, be necessary to provide the epilepsy therapy that a kind of therapeutic effect is better and sequela is less system.
A kind of epilepsy therapy system, comprise data acquisition unit, central processor and stimulating apparatus;
The acceleration change that described data acquisition unit moves for the Real-time Collection limbs of patient, and described acceleration change is transferred to described central processor;
Described central processor is used for the described acceleration change of real-time analysis, and is preset with the threshold value of acceleration change in described central processor;
Described stimulating apparatus is for applying stimulus signal, and so that the patient is carried out to stimulation therapy, wherein, described stimulus signal is at least one in optical signal and the signal of telecommunication;
When described acceleration change reaches default threshold value, described central processor is controlled described stimulating apparatus and is applied stimulus signal the patient is carried out to stimulation therapy.
In embodiment, described data acquisition unit comprises gravity sensing unit and data transmission unit therein;
Described gravity sensing unit is for the acceleration change of Real-time Collection limbs of patient motion;
Described data transmission unit is for transferring to described central processor by described acceleration change.
In embodiment, described gravity sensing unit is subcutaneous by being implanted in patient's upper limb forearm therein, to measure the limbs of patient acceleration of motion, changes.
In embodiment, described gravity sensing unit is fixed on the wrist place by wrist strap therein, to measure the limbs of patient acceleration of motion, changes.
In embodiment, described central processor comprises the data memory module that reaches the acceleration change of predetermined threshold value for storage therein.
In embodiment, described epilepsy therapy system also comprises the seizure monitoring device therein;
Described seizure monitoring device comprises wireless signal transmission unit and external terminal unit;
When described acceleration change reaches default threshold value, described central processor is by the described external terminal unit of described wireless signal transmission unit activating, and described external terminal unit is reported to the police by default alert program.
In embodiment, described external terminal unit comprises the input module of the stimulus parameter for setting described stimulating apparatus therein.
In embodiment, described epilepsy therapy system also comprises supply unit therein, and described supply unit adopts the mode of radio frequency powered to described data acquisition unit, described central processor, described stimulating apparatus and the power supply of described wireless signal transmission unit.
In embodiment, described stimulating apparatus comprises for the optical fiber of patients with implantation head and microlaser therein;
Described central processor is controlled described microlaser Emission Lasers signal, and described laser signal, imports and has the cell of photaesthesia gene to carry out the photostimulation treatment patient's head by described fiber-optic transfer to patient's head.
In embodiment, described stimulating apparatus comprises the stimulating electrode for the patients with implantation head therein;
Described central processor is controlled the described stimulating apparatus emission signal of telecommunication, and the described signal of telecommunication transfers in patient's head by described stimulating electrode, and the patient is carried out to electronic stimulation.
During above-mentioned epilepsy therapy system works, first data acquisition unit is fixed on patient's limbs.Data acquisition unit is measured the acceleration change of limbs of patient motion in real time, simultaneously central processor real-time analysis acceleration change.In acceleration change reaches central processor during default threshold value, central processor is controlled stimulating apparatus and is applied stimulus signal the patient is carried out to stimulation therapy.Therefore, above-mentioned epilepsy therapy system can be treated the patient in real time.Neurocyte is stimulated to effectively inhibitory neuron ion channel, thereby above-mentioned epilepsy therapy system has therapeutic effect preferably to epilepsy.Above-mentioned epilepsy therapy system does not need to use medicine, and does not need excision or damage local brain tissue, with respect to traditional epilepsy therapy, has less sequela.
The accompanying drawing explanation
The structural representation of the epilepsy therapy system that Fig. 1 is an embodiment.
The specific embodiment
For the ease of understanding the present invention, below with reference to relevant drawings, the present invention is described more fully.Provided preferred embodiment of the present invention in accompanying drawing.But the present invention can realize in many different forms, is not limited to embodiment described herein.On the contrary, provide the purpose of these embodiment be make the understanding of disclosure of the present invention more comprehensively thorough.
It should be noted that, when element is called as " being fixed in " another element, can directly can there be element placed in the middle in it on another element or also.When an element is considered to " connection " another element, it can be directly connected to another element or may have centering elements simultaneously.
Unless otherwise defined, all technology that this paper is used are identical with the implication that belongs to the common understanding of those skilled in the art of the present invention with scientific terminology.The term used in description of the present invention herein, just in order to describe the purpose of specific embodiment, is not intended to be restriction the present invention.Term as used herein " and/or " comprise one or more relevant Listed Items arbitrarily with all combinations.
As shown in Figure 1, the epilepsy therapy system 10 of an embodiment, comprise data acquisition unit 100, central processor 200, stimulating apparatus 300, seizure monitoring device 400 and supply unit 500.
Epileptic's period of disease has unpredictability, in time the epileptic is treated most important.
In the present embodiment, data acquisition unit 100 comprises gravity sensing unit 110 and data transmission unit 120.Wherein, gravity sensing unit 110 is for the acceleration change of Real-time Collection limbs of patient motion, and data transmission unit 120 changes and transfers to central processor 200 for degree of will speed up.
For the epileptic, it is health that stage of attack comparatively significantly indicates, especially the tic behavior of extremity.Because tic behavior and normal behavior have very large difference, therefore can be distinguished by the acceleration change parameter of gravity sensing unit 110.In the present embodiment, gravity sensing unit 110 is subcutaneous by being implanted in patient's upper limb forearm, to measure in real time the limbs of patient acceleration of motion, changes.Be appreciated that in other embodiments, the gravity sensing unit can be fixed on the wrist place by wrist strap, to measure in real time the limbs of patient acceleration of motion, changes.
In the present embodiment, central processor 200 comprises data memory module 210.Data memory module 210 reaches the acceleration change of predetermined threshold value for storage, thereby makes above-mentioned epilepsy therapy system 10 energy real time record epileptics' outbreak level (size of acceleration change) and attack times, the convenient disease situation of passing judgment on the patient.
Stimulating apparatus 300 is for applying stimulus signal, so that the patient is carried out to stimulation therapy.Wherein, stimulus signal is at least one in optical signal and the signal of telecommunication.
When acceleration change reaches default threshold value, central processor 200 is controlled stimulating apparatus 300 and is applied stimulus signal the patient is carried out to stimulation therapy.Because epilepsy is the of short duration handicapped a kind of chronic disease of brain that the electric discharge of cerebral neuron paroxysmal abnormality causes.The mechanism of action that prevents the clinical episodes of epilepsy with antiepileptic is mainly the inhibition to the neuron ion channel.Neurocyte is stimulated and can effectively suppress or excitor nerve unit ion channel.
In the present embodiment, stimulating apparatus 300 comprise optical fiber 310 for the patients with implantation head, for the microlaser (not shown) of patients with implantation head and for the stimulating electrode 320 of patients with implantation head.Central processor 200 is controlled microlaser utilizing emitted light signal, and optical signal is transported in patient's head tissue by optical fiber transmission 310, and patient's head tissue is carried out to the photostimulation treatment.Central processor 200 is controlled the stimulating apparatus 300 emission signals of telecommunication, and the signal of telecommunication transfers in patient's head tissue by stimulating electrode 320, and patient's head tissue is carried out to electronic stimulation.Thereby above-mentioned epilepsy therapy system 10, when adopting photostimulation to carry out stimulation therapy to the patient, can also adopt electricity irritation to carry out stimulation therapy to the patient, reaches the effect of auxiliary treatment.Be appreciated that in other embodiments, also can adopt separately photostimulation or electricity irritation to carry out stimulation therapy to the patient.
In the present embodiment, the optical signal of microlaser emission and importing in advance have the cell interaction of photaesthesia gene.Be also that present embodiment adopts light genetic technique (Optogenetics) to be regulated and controled the irritability of focus neurocyte.The cardinal principle of light genetic technique: at first adopt gene technology the photaesthesia gene to be transferred in the cell of particular type in nervous system and expressed, make it form special ion channel on cell membrane.These ion channels can be respectively under the light stimulation of different wave length to cation or anion pass through produce selectivity, thereby cause the transmembrane potential on cell membrane both sides to change, reach the purpose to the excitement of cell selective ground or inhibition.Stimulate (Transcranial Magnetic Stimulation than cranium magnetic, TMS) and dark electrical brain stimulation (Deep Brain Stimulation, DBS), light hereditism control technique has higher spatial resolution and cell selective, is a kind of more desirable method that suppresses epilepsy.
Therefore, before the epileptic is carried out to the photostimulation treatment, need lead-in light sensitive gene in the neurocyte of epileptic's head in advance.The photaesthesia gene imports to the interior also expression of neuron of associated loop, and wherein, the excited type channel protein gene is Channelrhodopsin-2(ChR2), inhibition type channel protein gene is Helorhodopsin(NpHR).The optical signal that the microlaser emission wavelength is 472nm (blue laser) stimulates expresses the neuron that the excited type channel protein gene is arranged, by such neuron of excitement; The optical signal that the microlaser emission wavelength is 593nm (yellow laser) stimulates expresses the neuron that inhibition type channel protein gene is arranged, and will suppress such neuron.Realize the regulation and control of neural circuit by excitement or inhibitory neuron, thereby arrive the purpose for the treatment of epilepsy.Because blue laser and yellow laser only have the cell of photaesthesia gene to work to importing, the treatment target spot of above-mentioned epilepsy therapy system 10 and treatment mechanism are clear and definite.Therefore, above-mentioned epilepsy therapy system 10 has therapeutic effect preferably, and has higher spatial resolution and cell selective.
Seizure monitoring device 400 comprises wireless signal transmission unit 410 and external terminal unit 420.
When acceleration change reaches default threshold value, central processor 200 is controlled stimulating apparatus 300 and is applied stimulus signal the patient is carried out to stimulation therapy.Central processor 200 activates external terminal unit 420 by wireless signal transmission unit 410 simultaneously, and external terminal unit 420 is reported to the police by default alert program, guarantees to greatest extent patient safety.Therefore, above-mentioned epilepsy therapy system 10 is carrying out can also carrying out Real-Time Monitoring to the patient in treatment in real time to the patient.
In the present embodiment, when acceleration change reaches default threshold value, central processor 200 control data memory modules 210 will reach default acceleration change and transfer to wireless signal transmission unit 410, wireless signal transmission unit 410 will reach default acceleration change again and be transmitted to external terminal unit 420 by wireless mode, activate external terminal unit 420.Thereby can effectively reduce central processor 200 number of times that 410 transmission accelerations change to the wireless signal transmission unit.Be appreciated that in other embodiments, central processor 200 also can directly be transferred to wireless signal transmission unit 410 by real-time acceleration change.
Wherein, warning message comprises the calling for help showed with form of sound, the patient's who shows with written form and form of sound outbreak situation and geographical position.Therefore, whether guardian or doctor just can understand in real time the patient by the outer terminal unit 420 of portable object and fall ill, and guarantee to greatest extent patient safety.
Above-mentioned seizure monitoring device 400 can carry out long term monitoring to the patient, and the electrophysiological change that the acceleration change of monitoring limbs of patient motion is compared the monitoring patient has larger advantage.The equipment of electrophysiologic monitoring is relatively expensive, and the data volume of record is very large, complex disposal process, the real-time long term monitoring of more difficult realization to the patient.
In the present embodiment, external terminal unit 420 comprises input module 422.Input module 422 is for setting the stimulus parameter of stimulating apparatus 300.Thereby while stating in the use epilepsy therapy system 10, can be according to the size of acceleration change, selective light stimulation or electricity irritation and the suitable stimulus parameter is set.
During above-mentioned epilepsy therapy system 10 work, first data acquisition unit 100 is fixed on patient's limbs.Data acquisition unit 100 is measured the acceleration change of limbs of patient motion, central processor 200 real-time analysis acceleration change simultaneously in real time.When acceleration change reaches the interior default threshold value of central processor 200, central processor 200 control stimulating apparatus 300 apply stimulus signal the patient are carried out to stimulation therapy.Therefore, above-mentioned epilepsy therapy system 10 can be treated the patient in real time.Neurocyte is stimulated to effectively inhibitory neuron ion channel, thereby 10 pairs of epilepsies of above-mentioned epilepsy therapy system has therapeutic effect preferably.Above-mentioned epilepsy therapy system 10 does not need to use medicine, and does not need excision or damage local brain tissue, with respect to traditional epilepsy therapy, has less sequela.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. an epilepsy therapy system, is characterized in that, comprises data acquisition unit, central processor and stimulating apparatus;
The acceleration change that described data acquisition unit moves for the Real-time Collection limbs of patient, and described acceleration change is transferred to described central processor;
Described central processor is used for the described acceleration change of real-time analysis, and is preset with the threshold value of acceleration change in described central processor;
Described stimulating apparatus is for applying stimulus signal, and so that the patient is carried out to stimulation therapy, wherein, described stimulus signal is at least one in optical signal and the signal of telecommunication;
When described acceleration change reaches default threshold value, described central processor is controlled described stimulating apparatus and is applied stimulus signal the patient is carried out to stimulation therapy.
2. epilepsy therapy system according to claim 1, is characterized in that, described data acquisition unit comprises gravity sensing unit and data transmission unit;
Described gravity sensing unit is for the acceleration change of Real-time Collection limbs of patient motion;
Described data transmission unit is for transferring to described central processor by described acceleration change.
3. epilepsy therapy system according to claim 2, is characterized in that, described gravity sensing unit is subcutaneous by being implanted in patient's upper limb forearm, to measure the limbs of patient acceleration of motion, changes.
4. epilepsy therapy system according to claim 2, is characterized in that, described gravity sensing unit is fixed on the wrist place by wrist strap, to measure the limbs of patient acceleration of motion, changes.
5. epilepsy therapy system according to claim 1, is characterized in that, described central processor comprises the data memory module that reaches the acceleration change of predetermined threshold value for storage.
6. epilepsy therapy system according to claim 1, is characterized in that, described epilepsy therapy system also comprises the seizure monitoring device;
Described seizure monitoring device comprises wireless signal transmission unit and external terminal unit;
When described acceleration change reaches default threshold value, described central processor is by the described external terminal unit of described wireless signal transmission unit activating, and described external terminal unit is reported to the police by default alert program.
7. epilepsy therapy system according to claim 6, is characterized in that, described external terminal unit comprises the input module of the stimulus parameter for setting described stimulating apparatus.
8. epilepsy therapy system according to claim 6, it is characterized in that, described epilepsy therapy system also comprises supply unit, and described supply unit adopts the mode of radio frequency powered to described data acquisition unit, described central processor, described stimulating apparatus and the power supply of described wireless signal transmission unit.
9. epilepsy therapy system according to claim 1, is characterized in that, described stimulating apparatus comprises for the optical fiber of patients with implantation head and microlaser;
Described central processor is controlled described microlaser Emission Lasers signal, and described laser signal, imports and has the cell of photaesthesia gene to carry out the photostimulation treatment patient's head by described fiber-optic transfer to patient's head.
10. epilepsy therapy system according to claim 1, is characterized in that, described stimulating apparatus comprises the stimulating electrode for the patients with implantation head;
Described central processor is controlled the described stimulating apparatus emission signal of telecommunication, and the described signal of telecommunication transfers in patient's head by described stimulating electrode, and the patient is carried out to electronic stimulation.
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| CN2013104096850A CN103446673A (en) | 2013-09-09 | 2013-09-09 | Epilepsy treatment system |
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| CN2013104096850A CN103446673A (en) | 2013-09-09 | 2013-09-09 | Epilepsy treatment system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105561474A (en) * | 2015-02-20 | 2016-05-11 | 邵志辉 | Device for treating epilepsy by stimulating vagus nerves of human body |
| CN109125929A (en) * | 2017-06-27 | 2019-01-04 | 浙江和也健康科技有限公司 | For treating the device of neurodegenerative disease |
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| CN102500058A (en) * | 2011-10-28 | 2012-06-20 | 广西师范大学 | Neurologic disease physiotherapeutic instrument based on brain waves and use method thereof |
| US20130154827A1 (en) * | 2011-12-16 | 2013-06-20 | Richard Housley | Convulsive seizure detection and notification system |
| CN103189100A (en) * | 2010-10-29 | 2013-07-03 | 美敦力公司 | Implantable medical device telemetry in disruptive energy field |
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Patent Citations (4)
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|---|---|---|---|---|
| US20090062696A1 (en) * | 2007-05-18 | 2009-03-05 | Vaidhi Nathan | Abnormal motion detector and monitor |
| CN103189100A (en) * | 2010-10-29 | 2013-07-03 | 美敦力公司 | Implantable medical device telemetry in disruptive energy field |
| CN102500058A (en) * | 2011-10-28 | 2012-06-20 | 广西师范大学 | Neurologic disease physiotherapeutic instrument based on brain waves and use method thereof |
| US20130154827A1 (en) * | 2011-12-16 | 2013-06-20 | Richard Housley | Convulsive seizure detection and notification system |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105561474A (en) * | 2015-02-20 | 2016-05-11 | 邵志辉 | Device for treating epilepsy by stimulating vagus nerves of human body |
| CN105561474B (en) * | 2015-02-20 | 2019-05-17 | 泰州市人民医院 | A kind of device for treating epilepsy by stimulation human body vagus nerve |
| CN109125929A (en) * | 2017-06-27 | 2019-01-04 | 浙江和也健康科技有限公司 | For treating the device of neurodegenerative disease |
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Application publication date: 20131218 |