CN103499519A - Composite physical field transdermal drug delivery experiment device - Google Patents
Composite physical field transdermal drug delivery experiment device Download PDFInfo
- Publication number
- CN103499519A CN103499519A CN201310467795.2A CN201310467795A CN103499519A CN 103499519 A CN103499519 A CN 103499519A CN 201310467795 A CN201310467795 A CN 201310467795A CN 103499519 A CN103499519 A CN 103499519A
- Authority
- CN
- China
- Prior art keywords
- chamber
- receiving chamber
- experimental provision
- electrode
- replenishing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention discloses a composite physical field transdermal drug delivery experiment device. The composite physical field transdermal drug delivery experiment device comprises a supplying chamber, a receiving chamber and a replenishing chamber, wherein the supplying chamber is used for storing a to-be-permeated standard solution prepared in an experiment; the receiving chamber is used for storing standard normal saline; the supplying chamber and the receiving chamber are separated by a sandwiched layer; the sandwiched layer is provided with a permeation hole which is provided with experiment skin enabling the standard solution in the supplying chamber to enter the standard normal saline in the receiving chamber in a permeated mode; the replenishing chamber is used for replenishing the standard normal saline to the receiving chamber; the lower part of the replenishing chamber is communicated with the receiving chamber, and the liquid level in the replenishing chamber is higher than that in the receiving chamber; the supplying chamber is internally provided with an electrode for applying an electric field to the permeation process of the standard solution. According to the composite physical field transdermal drug delivery experiment device disclosed by the invention, action factors of ultrasonic wave, the electric field and the like act on the experiment skin simultaneously through the arrangement that the electrode is embedded into an electrode groove; moreover, the replenishing chamber is also arranged for replenishing solutions to the receiving chamber effectively, so that the solutions in the receiving chamber after solution taking are still in contact with a skin model, and the experiment is not affected.
Description
Technical field
The present invention relates to a kind of cutaneous penetration diffusion experiment device, especially relate to a kind of compound physical field percutaneous dosing experimental provision.
Background technology
Cutaneous penetration is a kind of non-invasive administration new way, and its drug absorption is not subject to the impact of the complicated factors such as alimentary canal and enteron aisle, and overcome that the drug oral bioavilability is low, injection pain and liver first-pass effect.The various physical enhancement methods such as iontophoresis, iontophoresis, electroporation can be improved the skin permeability, increase the transmitance of medicine.
While in the percutaneous dosing process, using certain short infiltration method separately, its facilitation to percutaneous drug absorption is not very desirable.Most research all is devoted to two or more short infiltration methods and is combined use, makes them to the infiltration of medicine, produce synergy.Various short oozing make the transdermal technology obtain significant progress aspect security, high efficiency, targeting combining of technology.At field of medicaments, transdermal drug delivery system will be familiar with and study by increasing researcher as not a kind of alternative delivery system.
Along with compound short further investigation of oozing, the simple experimental provisions such as Franz diffusion cell, Valia-Chien diffusion cell, two Room circulation diffusion cells, self-control diffusion cell can not meet compound short demand of oozing experiment far away.Be designed although more and more simulate in recent years the Franz disperser, can't meet equally the compound short requirement of experiment of oozing that multiple physical agent applies simultaneously.
Improve the limitation in existing diffusion experiment medicine pond, design and can apply the compound short experimental provision oozed of multiple physical agent simultaneously, be convenient to the compound short further investigation of oozing experiment of physical field, promote the compound short development of oozing of physical field.
Summary of the invention
The objective of the invention is the deficiency for solving the problems of the technologies described above, a kind of compound physical field percutaneous dosing experimental provision is provided, solved the problem that the acting factors such as ultrasound wave and electric field can't act on simultaneously.
The present invention is the deficiency solved the problems of the technologies described above, and the technical scheme adopted is:
A kind of compound physical field percutaneous dosing experimental provision, the supply chamber that comprises the standard solution to be infiltrated for storing when experiment preparation, for the receiving chamber of depositing standard physiological saline, supply chamber and receiving chamber separate by interlayer, start to have permeability hole on interlayer, be provided with the standard solution made in supply chamber on permeability hole and enter the experiment skin in the standard physiological saline in receiving chamber by penetration mode, also be provided with for supplement the replenishing chamber of standard physiological saline to receiving chamber, the bottom of replenishing chamber is communicated with receiving chamber, and the liquid level in replenishing chamber is higher than the liquid level in receiving chamber, in supply chamber, be provided with for apply the electrode of electric field to the standard solution process of osmosis.
Offer on the interlayer of described permeability hole both sides for laying the slot electrode of electrode, in supply chamber, on two opposing sidewalls, be symmetrical arranged the glass clamp base that is useful on fixed electorde.
The distance of described glass clamp base and interlayer is 12-18mm.
The distance of described glass clamp base and interlayer is 15mm.
The 0.8-1.2 that the degree of depth of described slot electrode is thickness of electrode doubly.
The degree of depth of described slot electrode is identical with the thickness of electrode.
Described skin model seals and is fixed on permeability hole by O-ring seal.
Offer on described receiving chamber sidewall for extracting the liquid outlet of the rear solution of infiltration, be provided with openable sealing-plug in liquid outlet.
In described receiving chamber, magnetic stir bar is installed.
Described magnetic stir bar is positioned at the below of permeability hole.
The invention has the beneficial effects as follows: the present invention acts on experiment skin by the acting factors such as having realized ultrasound wave and electric field that arranges of electrode intercalation electrode groove simultaneously, can be effectively to receiving chamber's make-up solution but also be provided with replenishing chamber, make and get the solution in receiving chamber after liquid and, still with the skin model contact, do not affect experiment.
The accompanying drawing explanation
The one-piece construction 45 degree oblique views that Fig. 1 is experimental provision of the present invention;
The one-piece construction vertical view that Fig. 2 is experimental provision of the present invention;
Fig. 3 is experimental provision one-piece construction side view of the present invention;
Fig. 4 is that experimental provision of the present invention is subject to chamber and communication chamber structural drawing;
The sandwich construction figure that Fig. 5 is experimental provision of the present invention;
Fig. 6 is fixedly schematic diagram of experimental provision skin of the present invention.
Graphical indicia: 1, supply chamber, 2, receiving chamber, 3, electrode cable, 4, electrode, 401, slot electrode, 5, permeability hole, 6, magnetic stir bar, 7, the glass clamp base, 8, adjustable glass folder bolt, 9, replenishing chamber, 10, interlayer, 11, glass clamp base boring, 12, liquid outlet, 13, skin model, 14, O-ring seal.
Embodiment
Shown in figure, embodiment is as follows:
A kind of compound physical field percutaneous dosing experimental provision, the supply chamber 1 that comprises the standard solution to be infiltrated for storing when experiment preparation, for the receiving chamber of depositing standard physiological saline, supply chamber 1 separates by interlayer 10 with receiving chamber 2, start to have permeability hole 5 on interlayer 10, be provided with the standard solution made in supply chamber 1 on permeability hole 5 and enter the skin model 13 in the standard physiological saline in receiving chamber by penetration mode, it is characterized in that: also be provided with for supplement the replenishing chamber of standard physiological saline to receiving chamber 2, the bottom of replenishing chamber is communicated with receiving chamber 2, and the liquid level in replenishing chamber is higher than the liquid level in receiving chamber 2, in supply chamber 1, be provided with for apply the electrode of electric field to the standard solution process of osmosis.
Offer the slot electrode 401 for laying electrode 4 on the interlayer 10 of described permeability hole 5 both sides, on interior two opposing sidewalls of supply chamber 1, be symmetrical arranged the glass clamp base 7 that is useful on fixed electorde 4.
Described glass clamp base 7 is 12-18mm with the distance of interlayer 10.
Described glass clamp base 7 is 15mm with the distance of interlayer 10.
The 0.8-1.2 that the degree of depth of described slot electrode 401 is electrode 4 thickness doubly.
The degree of depth of described slot electrode 401 is identical with the thickness of electrode 4.
Described skin model 13 is arranged on permeability hole 5 by O-ring seal 14 sealings.
Offer on described receiving chamber 2 sidewalls for extracting the liquid outlet 12 of the rear solution of infiltration, be provided with openable sealing-plug in liquid outlet 12.
In described receiving chamber 2, magnetic stir bar 6 is installed.
Described magnetic stir bar 6 is positioned at the below of permeability hole 5.
In concrete experimentation, at first produce vertical experimental provision on basis, top is supply chamber referred to as for chamber, and bottom is that receiving chamber is referred to as being subject to chamber.Specifically as shown in the part-structure of Fig. 1.During experiment, for the actual useful volume in chamber, can determine according to the experiment concrete condition, for on the left and right sides wall of chamber, a pair of glass clamp base is arranged respectively, and be arranged in the boring of sidewall upper glass folder base, the height of glass clamp base distance means bottom surface is adjustable, wherein gets 15mm comparatively suitable.As shown in Figure 1.
Secondly, produce connected component as replenishing chamber in the left side of above-mentioned vertical experimental provision.The bottom of replenishing chamber communicates with the chamber of being subject to, and whole replenishing chamber does not communicate with supplying chamber.As shown in Figure 4.
Again, being subject between chamber and replenishing chamber is to be communicated with fully, and with for not being communicated with between chamber.Experimental agents only is penetrated into and is subject to ，Shou chamber, chamber variable volume by the permeability hole on interlayer, with reference to related data, can be designed as 125ml.Be subject to chamber, replenishing chamber and interbedded structure and annexation as shown in Figure 4.
The embodiment of experimental provision sandwich portion is as follows: the interlayer size should match with supplying He Shou chamber, chamber, and just is placed between the two.Be designed with the permeability hole of Medicated Permeation on interlayer, the both sides in hole are designed with the groove that a pair of degree of depth is consistent with thickness of electrode, so that electrode embeds wherein.According to the structure function of this experimental provision, the diameter value of this permeability hole should be 40mm, and effectively infiltrating area is 12.56cm
2.One end of two electrodes all is connected to wire, as shown in 3 in Fig. 1,4.
The principle of work of interlayer and accessory structure thereof: after placed is good, glass clamp base fixing skin together with cap rock, O-ring seal.After skin center and permeability hole center superposition place, place O-ring seal and cap rock thereon.Fixedly schematic diagram is as shown in Figure 6 for skin.
Finally, wire bonds, on silver electrode, and is placed on the silver electrode of having welded in slot electrode.
The technical scheme that the present invention is cited and embodiment are not restrictions, in the cited technical scheme of the present invention and embodiment is equal to or the effect same approach is all protected in the present invention scope.
Claims (10)
1. a compound physical field percutaneous dosing experimental provision, the supply chamber (1) that comprises the standard solution to be infiltrated for storing when experiment preparation, for the receiving chamber of depositing standard physiological saline, supply chamber (1) separates by interlayer (10) with receiving chamber (2), start that permeability hole is arranged (5) on interlayer (10), be provided with the standard solution made in supply chamber (1) on permeability hole (5) and enter the skin model (13) in the standard physiological saline in receiving chamber by penetration mode, it is characterized in that: also be provided with for supplement the replenishing chamber of standard physiological saline to receiving chamber (2), the bottom of replenishing chamber is communicated with receiving chamber (2), and the liquid level in replenishing chamber is higher than the liquid level in receiving chamber (2), in supply chamber (1), be provided with for apply the electrode of electric field to the standard solution process of osmosis.
2. a kind of compound physical according to claim 1 field percutaneous dosing experimental provision, it is characterized in that: offer the slot electrode (401) for laying electrode (4) on the interlayer (10) of described permeability hole (5) both sides, on interior two opposing sidewalls of supply chamber (1), be symmetrical arranged the glass clamp base (7) that is useful on fixed electorde (4).
3. a kind of compound physical according to claim 2 field percutaneous dosing experimental provision is characterized in that: described glass clamp base (7) is 12-18mm with the distance of interlayer (10).
4. a kind of compound physical according to claim 3 field percutaneous dosing experimental provision is characterized in that: described glass clamp base (7) is 15mm with the distance of interlayer (10).
5. a kind of compound physical according to claim 2 field percutaneous dosing experimental provision, is characterized in that: the 0.8-1.2 that the degree of depth of described slot electrode (401) is electrode (4) thickness times.
6. a kind of compound physical according to claim 5 field percutaneous dosing experimental provision, it is characterized in that: the degree of depth of described slot electrode (401) is identical with the thickness of electrode (4).
7. a kind of compound physical according to claim 1 field percutaneous dosing experimental provision is characterized in that: described skin model (13) is fixed on permeability hole (5) by O-ring seal (14) sealing.
8. a kind of compound physical according to claim 1 field percutaneous dosing experimental provision, it is characterized in that: on described receiving chamber (2) sidewall, offer for extracting the liquid outlet (12) of the rear solution of infiltration, liquid outlet is provided with openable sealing-plug in (12).
9. a kind of compound physical according to claim 1 field percutaneous dosing experimental provision, is characterized in that: magnetic stir bar (6) is installed in described receiving chamber (2).
10. a kind of compound physical according to claim 9 field percutaneous dosing experimental provision, it is characterized in that: described magnetic stir bar (6) is positioned at the below of permeability hole (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310467795.2A CN103499519A (en) | 2013-10-10 | 2013-10-10 | Composite physical field transdermal drug delivery experiment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310467795.2A CN103499519A (en) | 2013-10-10 | 2013-10-10 | Composite physical field transdermal drug delivery experiment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103499519A true CN103499519A (en) | 2014-01-08 |
Family
ID=49864749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310467795.2A Pending CN103499519A (en) | 2013-10-10 | 2013-10-10 | Composite physical field transdermal drug delivery experiment device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103499519A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A kind of suspending agent flowing release test flowing lumen |
| WO2019157833A1 (en) * | 2018-02-13 | 2019-08-22 | 常州华佳医疗器械有限公司 | Novel smart transdermal and oral administration equipment and method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US5162042A (en) * | 1988-07-05 | 1992-11-10 | Alza Corporation | Electrotransport transdermal system |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
| US5533971A (en) * | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
| CN1592644A (en) * | 2001-04-06 | 2005-03-09 | 马蒂奥利工程有限公司 | Apparatus for skin absorption enhancement |
| CN1832777A (en) * | 2003-06-02 | 2006-09-13 | 纸型电池有限公司 | Kit, device and method for controlled delivery of oxidizing agent into the skin |
| CN1832778A (en) * | 2003-05-30 | 2006-09-13 | 马蒂奥利工程有限公司 | Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs |
| US20120324984A1 (en) * | 2009-12-01 | 2012-12-27 | Health Protection Agency | Assay method and apparatus |
| CN203551437U (en) * | 2013-10-10 | 2014-04-16 | 河南科技大学 | Composite physical field transdermal drug delivery experimental facility |
-
2013
- 2013-10-10 CN CN201310467795.2A patent/CN103499519A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594884A (en) * | 1984-06-21 | 1986-06-17 | Merck & Co., Inc. | Diffusion measuring device |
| US5162042A (en) * | 1988-07-05 | 1992-11-10 | Alza Corporation | Electrotransport transdermal system |
| US5356632A (en) * | 1991-09-12 | 1994-10-18 | S.I. Scientific Innovations Ltd. | Transdermal drug delivery device |
| US5298017A (en) * | 1992-12-29 | 1994-03-29 | Alza Corporation | Layered electrotransport drug delivery system |
| US5533971A (en) * | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
| CN1592644A (en) * | 2001-04-06 | 2005-03-09 | 马蒂奥利工程有限公司 | Apparatus for skin absorption enhancement |
| CN1832778A (en) * | 2003-05-30 | 2006-09-13 | 马蒂奥利工程有限公司 | Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs |
| CN1832777A (en) * | 2003-06-02 | 2006-09-13 | 纸型电池有限公司 | Kit, device and method for controlled delivery of oxidizing agent into the skin |
| US20120324984A1 (en) * | 2009-12-01 | 2012-12-27 | Health Protection Agency | Assay method and apparatus |
| CN203551437U (en) * | 2013-10-10 | 2014-04-16 | 河南科技大学 | Composite physical field transdermal drug delivery experimental facility |
Non-Patent Citations (2)
| Title |
|---|
| 岳奇峰 等: "电致孔条件下不同电学参数对青藤碱透皮给药的影响", 《中草药》, vol. 37, no. 11, 30 November 2006 (2006-11-30), pages 1639 - 1641 * |
| 程昊 等: "电致孔条件下秦艽水提液体外透皮给药最优电学参数的研究", 《中国药学杂志》, vol. 44, no. 22, 30 November 2009 (2009-11-30) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019157833A1 (en) * | 2018-02-13 | 2019-08-22 | 常州华佳医疗器械有限公司 | Novel smart transdermal and oral administration equipment and method |
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A kind of suspending agent flowing release test flowing lumen |
| CN109612898B (en) * | 2018-11-12 | 2021-06-04 | 禄根仪器(镇江)有限公司 | Flowable release test circulation cavity for suspending agent |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4793806B2 (en) | Iontophoresis device | |
| KR101772140B1 (en) | Iontophoresis device for drug delivery and method for manufacturing the same | |
| KR101028788B1 (en) | Device and method for controlled delivery of active substance into the skin | |
| WO2010001122A3 (en) | Patches for reverse iontophoresis | |
| US20090287208A1 (en) | Electrolytic tissue treatment | |
| CN105848564A (en) | Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing | |
| SG144143A1 (en) | Iontophoresis device | |
| NZ610305A (en) | User-activated self-contained co-packaged iontophoretic drug delivery system | |
| CN201564970U (en) | Transdermal medicine supply patch based on micro needle array flexible chip | |
| CN103157178B (en) | Seal type tool capable of accurately controlling microneedle insertion length | |
| Bhatia et al. | Effect of modulated alternating and direct current iontophoresis on transdermal delivery of lidocaine hydrochloride | |
| CN103499519A (en) | Composite physical field transdermal drug delivery experiment device | |
| CN203551437U (en) | Composite physical field transdermal drug delivery experimental facility | |
| WO2016056778A1 (en) | Iontophoresis device using reverse electrodialysis and drug delivery method using same | |
| CN101612092A (en) | A kind of bonded skin needle treating, doser | |
| CN204379984U (en) | Lead medicine physiotherapy electrode plate | |
| CN102936567B (en) | Microtopological-structure plate flow chamber capable of applying electric and shearing force stimulation | |
| CN204335849U (en) | For the siRNA cutaneous penetration brassiere of mastocarcinoma gene treatment | |
| KR101698147B1 (en) | Iontophoresis device using reversed electrodialysis and method for deliverying drug using the same | |
| CN104689465A (en) | Vacuum negative pressure ultrasonic transdermal drug delivery device | |
| Levin | Advances in radio-frequency transdermal drug delivery | |
| CN203007278U (en) | Flat flowing cavity capable of applying electricity and shearing force stimulation and provided with micro-topological structure | |
| CN202014660U (en) | Blood-pressure-decreasing insole | |
| CN206604016U (en) | Ultrasonic conductance probe head | |
| CN202314641U (en) | Implantable administration device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140108 |